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3. Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study

Author

Feys, Simon, Gonçalves, Samuel M, Khan, Mona, Choi, Sumin, Boeckx, Bram, Chatelain, Denis, Cunha, Cristina, Debaveye, Yves, Hermans, Greet, Hertoghs, Marjan, Humblet-Baron, Stephanie, Jacobs, Cato, Lagrou, Katrien, Marcelis, Lukas, Maizel, Julien, Meersseman, Philippe, Nyga, Rémy, Seldeslachts, Laura, Starick, Marick Rodrigues, Thevissen, Karin, Vandenbriele, Christophe, Vanderbeke, Lore, Vande Velde, Greetje, Van Regenmortel, Niels, Vanstapel, Arno, Vanmassenhove, Sam, Wilmer, Alexander, Van De Veerdonk, Frank L, De Hertogh, Gert, Mombaerts, Peter, Lambrechts, Diether, Carvalho, Agostinho, Van Weyenbergh, Johan, and Wauters, Joost

Published
2022
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4. Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb

Author

Khan, Mona, Yoo, Seung-Jun, Clijsters, Marnick, Backaert, Wout, Vanstapel, Arno, Speleman, Kato, Lietaer, Charlotte, Choi, Sumin, Hether, Tyler D., Marcelis, Lukas, Nam, Andrew, Pan, Liuliu, Reeves, Jason W., Van Bulck, Pauline, Zhou, Hai, Bourgeois, Marc, Debaveye, Yves, De Munter, Paul, Gunst, Jan, Jorissen, Mark, Lagrou, Katrien, Lorent, Natalie, Neyrinck, Arne, Peetermans, Marijke, Thal, Dietmar Rudolf, Vandenbriele, Christophe, Wauters, Joost, Mombaerts, Peter, and Van Gerven, Laura

Published
2021
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5. Carotid Body Function in Tyrosine Hydroxylase Conditional Olfr78 Knockout Mice.

Author

Colinas, Olalla, Mombaerts, Peter, López-Barneo, José, and Ortega-Sáenz, Patricia

Subjects
*CAROTID body, *KNOCKOUT mice, *TYROSINE hydroxylase, *SECRETORY granules, *OLFACTORY receptors, *BLOOD lactate, *CHEMORECEPTORS
Abstract

The Olfr78 gene encodes a G-protein-coupled olfactory receptor that is expressed in several ectopic sites. Olfr78 is one of the most abundant mRNA species in carotid body (CB) glomus cells. These cells are the prototypical oxygen (O2) sensitive arterial chemoreceptors, which, in response to lowered O2 tension (hypoxia), activate the respiratory centers to induce hyperventilation. It has been proposed that Olfr78 is a lactate receptor and that glomus cell activation by the increase in blood lactate mediates the hypoxic ventilatory response (HVR). However, this proposal has been challenged by several groups showing that Olfr78 is not a physiologically relevant lactate receptor and that the O2-based regulation of breathing is not affected in constitutive Olfr78 knockout mice. In another study, constitutive Olfr78 knockout mice were reported to have altered systemic and CB responses to mild hypoxia. To further characterize the functional role of Olfr78 in CB glomus cells, we here generated a conditional Olfr78 knockout mouse strain and then restricted the knockout to glomus cells and other catecholaminergic cells by crossing with a tyrosine hydroxylase-specific Cre driver strain (TH-Olfr78 KO mice). We find that TH-Olfr78 KO mice have a normal HVR. Interestingly, glomus cells of TH-Olfr78 KO mice exhibit molecular and electrophysiological alterations as well as a reduced dopamine content in secretory vesicles and neurosecretory activity. These functional characteristics resemble those of CB neuroblasts in wild-type mice. We suggest that, although Olfr78 is not essential for CB O2 sensing, activation of Olfr78-dependent pathways is required for maturation of glomus cells. Graphical Abstract [ABSTRACT FROM AUTHOR]

Published
2024
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22. A signature of differential gene expression in bronchoalveolar lavage fluid predicts mortality in influenza-associated pulmonary aspergillosis.

Author

Feys, Simon, Heylen, Jannes, Carvalho, Agostinho, Van Weyenbergh, Johan, Wauters, Joost, on behalf of the Variomic Study Group, Gonçalves, Samuel M., Cunha, Cristina, Debaveye, Yves, Hermans, Greet, Humblet-Baron, Stephanie, Jacobs, Cato, Lambrechts, Diether, Mombaerts, Peter, Lagrou, Katrien, Meersseman, Philippe, Menezes, Soraya Maria, Peetermans, Marijke, Rocha-Pereira, Joana, and Seldeslachts, Laura

Subjects
GENE expression, PULMONARY eosinophilia, GENE ontology, BRONCHOALVEOLAR lavage, PULMONARY aspergillosis
Abstract

Given this finding, we assessed whether the protein VEGF is associated with IAPA mortality as well using a dataset of BAL VEGF levels obtained from 40 patients, of whom 38 were included in the gene expression dataset [[2]]. We conclude that decreased lower respiratory tract expression of genes related to anti I Aspergillus i immunity and increased VEGF levels and VEGF-related signaling are associated with increased mortality in IAPA patients. [Extracted from the article]

Published
2023
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30. Local and cis Effects of the H Element on Expression of Odorant Receptor Genes in Mouse

Author

Fuss, Stefan H., Omura, Masayo, and Mombaerts, Peter

Subjects
Gene expression, Biological sciences
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cell.2007.06.023 Byline: Stefan H. Fuss (1), Masayo Omura (1), Peter Mombaerts (1) Keywords: MOLNEURO Abstract: From the [approximately equal to]1,200 odorant receptor (OR) genes in the mouse genome, an olfactory sensory neuron is thought to express only one gene. The mechanisms of OR gene choice are not understood. A 2.1 kilobase region (the H element) adjacent to a cluster of seven OR genes has been proposed as a trans- and pan-enhancer for OR gene expression. Here, we deleted the H element by gene targeting in mice. The deletion abolishes expression of a family of three OR genes proximal to H, and H operates in cis on these genes. Deletion of H has a graded effect on expression of a distal group of four OR genes, commensurate with genomic distance. There is no demonstrable effect on expression of OR genes located outside the cluster. Our findings are not consistent with the hypothesis of H as an essential trans-acting enhancer for genome-wide regulation of OR gene expression. Author Affiliation: (1) The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA Article History: Received 6 January 2007; Revised 8 March 2007; Accepted 13 June 2007 Article Note: (miscellaneous) Published: July 26, 2007

Published
2007

32. Love at first smell- The 2004 Nobel Prize in physiology or medicine

Author

Mombaerts, Peter

Subjects
Medical research -- Achievements and awards, Medicine, Experimental -- Achievements and awards
Abstract

Linda Buck and Richard Axel were awarded the 2004 Nobel Prize in Physiology or Medicine 'for their discoveries of odorant receptors and the organization of the olfactory system'. Buck and Axel in 1991 reported a large family of rat genes that, they hypothesized, encoded odorant receptors.

Published
2004

33. Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons

Author

Li, Jinsong, Ishii, Tomohiro, Feinstein, Paul, and Mombaerts, Peter

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Jinsong Li; Tomohiro Ishii; Paul Feinstein; Peter Mombaerts (corresponding author) The discovery of OR genes [1] gave rise to the idea that the choice of expression of one allele [...]

Published
2004
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36. Lung donation and SARS‐CoV‐2 transmission: Missed detection versus missed opportunity?

Author

Van Slambrouck, Jan, Van Raemdonck, Dirk, Wauters, Joost, Vos, Robin, Mombaerts, Peter, and Ceulemans, Laurens J.

Subjects
SARS-CoV-2, SARS-CoV-2 Omicron variant
Abstract

RT-PCR on a biopsy of the donor lung before LTx revealed a low viral load with a Ct value of 35, reflecting persistence of viral RNA. Keywords: lung transplantation; NAAT; point-of-care test; rapid antigen test; SARS-CoV-2 EN lung transplantation NAAT point-of-care test rapid antigen test SARS-CoV-2 1 5 5 03/31/22 20220401 NES 220401 Point-of-care tests may play a valuable role in reducing the risk of donor-derived SARS-CoV-2 transmission in lung transplantation. We anticipate that the COVID-19 pandemic will pave the way for a more regular use of POCTs to reduce the risk of donor-derived transmission of other pathogens that reside in the donor lungs. Donor to recipient transmission of SARS-CoV-2 by lung transplantation despite negative donor upper respiratory tract testing. [Extracted from the article]

Published
2022
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38. Odorant receptors instruct functional circuitry in the mouse olfactory bulb

Author

Belluscio, Leonardo, Lodovichi, Claudia, Feinstein, Paul, Mombaerts, Peter, and Katz, Lawrence C.

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Leonardo Belluscio (corresponding author) [1, 2]; Claudia Lodovichi [1]; Paul Feinstein [3]; Peter Mombaerts (corresponding author) [3]; Lawrence C. Katz [1] The mammalian olfactory system detects and discriminates thousands [...]

Published
2002
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39. Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes

Author

Del Punta, Karina, Leinders-Zufall, Trese, Rodriguez, Ivan, Jukam, David, Wysocki, Charles J., Ogawa, Sonoko, Zufall, Frank, and Mombaerts, Peter

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Karina Del Punta [1]; Trese Leinders-Zufall [2]; Ivan Rodriguez [1, 3]; David Jukam [1]; Charles J. Wysocki [4]; Sonoko Ogawa [1]; Frank Zufall [2]; Peter Mombaerts (corresponding author) [1] [...]

Published
2002
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44. The testicular soma of Tsc22d3 knockout mice supports spermatogenesis and germline transmission from spermatogonial stem cell lines upon transplantation

Author

Zhou, Hai, Zeng, Zhen, Köntgen, Frank, Khan, Mona, and Mombaerts, Peter

Subjects
endocrine system, ddc:610
Abstract

Spermatogonial stem cells (SSCs) are adult stem cells that are slowly cycling and self-renewing. The pool of SSCs generates very large numbers of male gametes throughout the life of the individual. SSCs can be cultured in vitro for long periods of time, and established SSC lines can be manipulated genetically. Upon transplantation into the testes of infertile mice, long-term cultured mouse SSCs can differentiate into fertile spermatozoa, which can give rise to live offspring. Here, we show that the testicular soma of mice with a conditional knockout (conKO) in the X-linked gene Tsc22d3 supports spermatogenesis and germline transmission from cultured mouse SSCs upon transplantation. Infertile males were produced by crossing homozygous Tsc22d3 floxed females with homozygous ROSA26-Cre males. We obtained 96 live offspring from six long-term cultured SSC lines with the aid of intracytoplasmic sperm injection. We advocate the further optimization of Tsc22d3-conKO males as recipients for testis transplantation of SSC lines.

Published
2019

50. Ageing[colon] Cloning of mice to six generations

Author

Wakayama, Teruhiko, Shinkai, Yoichi, Tamashiro, Kellie L. K., Niida, Hiroyuki, Blanchard, D. Caroline, Blanchard, Robert J., Ogura, Atsuo, Tanemura, Kentaro, Tachibana, Makoto, Perry, Anthony C. F., Colgan, Diana F., Mombaerts, Peter, and Yanagimachi, Ryuzo

Published
2000

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