Search

Your search keyword '"Moll van Charante, Eric P"' showing total 336 results
Start Over Author "Moll van Charante, Eric P" Language english
336 results on '"Moll van Charante, Eric P"'

2. Adding ethnicity to cardiovascular risk prediction: External validation and model updating of SCORE2 using data from the HELIUS population cohort

Author

van Apeldoorn, Joshua A.N., Hageman, Steven H.J., Harskamp, Ralf E., Agyemang, Charles, van den Born, Bert-Jan H., van Dalen, Jan Willem, Galenkamp, Henrike, Hoevenaar-Blom, Marieke P., Richard, Edo, van Valkengoed, Irene G.M., Visseren, Frank L.J., Dorresteijn, Jannick A.N., and Moll van Charante, Eric P.

Published
2024
Full Text
View/download PDF

4. Preconception lipid profile and the subsequent risk of pregnancy disorders characterized by uteroplacental dysfunction in a multi-ethnic population: the linked HELIUS–PERINED study

Author

Burger, Renée J., Reilingh, Annemarie Y.A.M., Moll Van Charante, Eric P., Born, Bert-Jan H. Van Den, Groot, Christianne J.M. De, Ravelli, Anita C.J., Weissenbruch, Mirjam M. Van, Galenkamp, Henrike, Valkengoed, Irene G.M. Van, Ganzevoort, Wessel, and Gordijn, Sanne J.

Published
2024
Full Text
View/download PDF

7. Prevention of dementia using mobile phone applications (PRODEMOS): a multinational, randomised, controlled effectiveness–implementation trial

Author

Witvliet, Patrick, Hoitink, Mart, van de Groep, Bram, Liu, Hongmei, Ge, Siqi, He, Mingyue, Li, Cancan, Jian, Xuening, Jiang, Bin, Sun, Haixin, Ru, Xiaojuan, Sun, Dongling, Lian, Tenghong, Zhang, Weijiao, Zhang, Wenjing, Qi, Jing, Li, Jinghui, Guan, Huiying, Luo, Dongmei, Zhang, Weijia, Yue, Hao, Zheng, Zijing, Zeng, Qiang, Yang, Huangdai, Tang, Yanyan, Tao, Tianqi, Song, Yan, Meng, Xiaosheng, Zhu, Sirui, Jia, Dongmei, Li, Mo, Li, Wenjie, Mu, Haiyan, Jiang, Wenjing, Gao, Wenchao, Hu, Yueqing, Wang, Guohua, Xu, Xizhu, Zhang, Yichun, Li, Dong, Zhang, Xiaoyu, Guo, Xiuhua, Ye, Xiaoyan, Wei, Xi, Moll van Charante, Eric P, Hoevenaar-Blom, Marieke P, Song, Manshu, Andrieu, Sandrine, Barnes, Linda, Birck, Cindy, Brooks, Rachael, Coley, Nicola, Eggink, Esmé, Georges, Jean, Hafdi, Melanie, van Gool, Willem A, Handels, Ron, Hou, Haifeng, Lyu, Jihui, Niu, Yixuan, Song, Libin, Wang, Wenzhi, Wang, Youxin, Wimo, Anders, Yu, Yueyi, Zhang, Jinxia, Zhang, Wei, Brayne, Carol, Wang, Wei, and Richard, Edo

Published
2024
Full Text
View/download PDF

13. Differences in SARS-CoV-2 infections during the first and second wave of SARS-CoV-2 between six ethnic groups in Amsterdam, the Netherlands: A population-based longitudinal serological study

Author

Coyer, Liza, Boyd, Anders, Schinkel, Janke, Agyemang, Charles, Galenkamp, Henrike, Koopman, Anitra D.M., Leenstra, Tjalling, van Duijnhoven, Yvonne T.H.P., Moll van Charante, Eric P., van den Born, Bert-Jan H., Lok, Anja, Verhoeff, Arnoud, Zwinderman, Aeilko H., Jurriaans, Suzanne, Stronks, Karien, and Prins, Maria

Published
2022
Full Text
View/download PDF

20. Healthy ageing through internet counselling in the elderly (HATICE): a multinational, randomised controlled trial

Author

Richard, Edo, Moll van Charante, Eric P, Hoevenaar-Blom, Marieke P, Coley, Nicola, Barbera, Mariagnese, van der Groep, Abraham, Meiller, Yannick, Mangialasche, Francesca, Beishuizen, Cathrien B, Jongstra, Susan, van Middelaar, Tessa, Van Wanrooij, Lennard L, Ngandu, Tiia, Guillemont, Juliette, Andrieu, Sandrine, Brayne, Carol, Kivipelto, Miia, Soininen, Hilkka, and Van Gool, Willem A

Published
2019
Full Text
View/download PDF

22. Ethnic Differences in Carotid Intima-Media Thickness and Plaque Presence: The HELIUS Study.

Author

Vriend, Esther M.C., Bouwmeester, Thomas A., Artola Arita, Vicente, Bots, Michiel L., Meijer, Rudy, Galenkamp, Henrike, Stronks, Karien, Collard, Didier, Moll van Charante, Eric P., van den Born, Bert-Jan H., and Franco, Oscar H.

Subjects
CAROTID intima-media thickness, CAROTID artery ultrasonography, STATURE, CARDIOVASCULAR diseases risk factors, ATHEROSCLEROTIC plaque
Abstract

Introduction: In the Netherlands, the prevalence of cardiovascular diseases (CVDs) is higher among South-Asian Surinamese and lower among Moroccans compared to the Dutch. Traditional risk factors for atherosclerotic CVD do not fully explain these disparities. We aimed to assess ethnic differences in plaque presence and carotid intima-media thickness (cIMT) and explore to what extent these differences are explained by traditional risk factors. Methods: We used cross-sectional data from a subgroup of participants enrolled in the multi-ethnic population-based Healthy Life in an Urban Setting (HELIUS) study who underwent carotid ultrasonography. Logistic and linear regression models were built to assess ethnic differences in plaque presence and cIMT with the Dutch population as reference. Additional models were created to adjust for socioeconomic status, body height, and cardiovascular risk factors. Results: Of the 3,022 participants, 1,183, 1,051, and 790 individuals were of Dutch, South-Asian Surinamese, and Moroccan descent, respectively. Mean age was 60.9 years (SD: 8.0), and 52.8% were female. Compared to the Dutch, we found lower odds for plaque presence in Moroccans (0.77, 95% CI: 0.62; 0.95) and no significant differences between the South-Asian Surinamese and Dutch population (0.91, 95% CI: 0.76; 1.10). After adjustment for CVD risk factors, we found a lower plaque presence in South-Asian Surinamese (0.63, 95% CI: 0.48; 0.82). In both Moroccan and South-Asian Surinamese individuals, adjustment for socioeconomic status did not materially change the results. cIMT was lower in South-Asian Surinamese compared to the Dutch (−17.9 μm, 95% CI: −27.9; −7.9) and partly explained by ethnic differences in the body height as South-Asian Surinamese individuals were, on average, shorter than the Dutch population. No differences in cIMT between Moroccans and Dutch were found. Conclusions: cIMT and plaque prevalence differ between ethnic groups independent of CVD risk. Lower plaque prevalence in Moroccans was partly attributable to a lower prevalence of traditional CVD risk factors, while body height was an important contributor to differences in cIMT in South Asians. This study emphasizes the need for ethnic-specific cut-off values for plaque presence and cIMT. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

25. Unravelling complex primary-care programs to maintain independent living in older people: a systematic overview

Author

Smit, Linda C., Schuurmans, Marieke J., Blom, Jeanet W., Fabbricotti, Isabelle N., Jansen, Aaltje P.D., Kempen, Gertrudis I.J.M., Koopmans, Raymond, Looman, Willemijn M., Melis, Rene J.F., Metzelthin, Silke F., Moll van Charante, Eric P., Muntinga, Maaike E., Ruikes, Franca G.H., Spoorenberg, Sophie L.W., Suijker, Jacqueline J., Wynia, Klaske, Gussekloo, Jacobijn, De Wit, Niek J., and Bleijenberg, Nienke

Published
2018
Full Text
View/download PDF

27. Investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis

Author

Peters, Ruth, Yasar, Sevil, Anderson, Craig S., Andrews, Shea, Antikainen, Riitta, Arima, Hisatomi, Beckett, Nigel, Beer, Joanne C., Bertens, Anne Suzanne, Booth, Andrew, van Boxtel, Martin, Brayne, Carol, Brodaty, Henry, Carlson, Michelle C., Chalmers, John, Corrada, Maria, DeKosky, Steven, Derby, Carol, Dixon, Roger A., Forette, Françoise, Ganguli, Mary, van Gool, Willem A., Guaita, Antonio, Hever, Ann M., Hogan, David B., Jagger, Carol, Katz, Mindy, Kawas, Claudia, Kehoe, Patrick G., Keinanen-Kiukaanniemi, Sirkka, Kenny, Rose Ann, Köhler, Sebastian, Kunutsor, Setor K., Laukkanen, Jari, Maxwell, Colleen, McFall, G. Peggy, van Middelaar, Tessa, Moll van Charante, Eric P., Ng, Tze-Pin, Peters, Jean, Rawtaer, Iris, Richard, Edo, Rockwood, Kenneth, Rydén, Lina, Sachdev, Perminder S., Skoog, Ingmar, Skoog, Johan, Staessen, Jan A., Stephan, Blossom C.M., Sebert, Sylvain, Thijs, Lutgarde, Trompet, Stella, Tully, Phillip J., Tzourio, Christophe, Vaccaro, Roberta, Vaaramo, Eeva, Walsh, Erin, Warwick, Jane, and Anstey, Kaarin J.

Published
2020
Full Text
View/download PDF

29. Diagnostic properties of natriuretic peptides and opportunities for personalized thresholds for detecting heart failure in primary care.

Author

Harskamp, Ralf E., De Clercq, Lukas, Veelers, Lieke, Schut, Martijn C., van Weert, Henk C.P.M., Handoko, M. Louis, Moll van Charante, Eric P., and Himmelreich, Jelle C.L.

Subjects
NATRIURETIC peptides, HEART failure, PRIMARY care, PEPTIDES, MEDICAL care costs, BRAIN natriuretic factor
Abstract

Heart failure (HF) is a prevalent syndrome with considerable disease burden, healthcare utilization and costs. Timely diagnosis is essential to improve outcomes. This study aimed to compare the diagnostic performance of B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) in detecting HF in primary care. Our second aim was to explore if personalized thresholds (using age, sex, or other readily available parameters) would further improve diagnostic accuracy over universal thresholds. A retrospective study was performed among patients without prior HF who underwent natriuretic peptide (NP) testing in the Amsterdam General Practice Network between January 2011 and December 2021. HF incidence was based on registration out to 90 days after NP testing. Diagnostic accuracy was evaluated with AUROC, sensitivity and specificity based on guideline-recommended thresholds (125 ng/L for NT-proBNP and 35 ng/L for BNP). We used inverse probability of treatment weighting to adjust for confounding. A total of 15,234 patients underwent NP testing, 6,870 with BNP (4.5 % had HF), and 8,364 with NT-proBNP (5.7 % had HF). NT-proBNP was more accurate than BNP, with an AUROC of 89.9 % (95 % CI: 88.4–91.2) vs. 85.9 % (95 % CI 83.5–88.2), with higher sensitivity (95.3 vs. 89.7 %) and specificity (59.1 vs. 58.0 %). Differentiating NP cut-off by clinical variables modestly improved diagnostic accuracy for BNP and NT-proBNP compared with a universal threshold. NT-proBNP outperforms BNP for detecting HF in primary care. Personalized instead of universal diagnostic thresholds led to modest improvement. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

31. Telephone and Smartphone-Based Interventions for Cognitive and Cardio-Metabolic Health in Middle-Aged and Older Adults: A Systematic Review

Author

Andre,Laurine, Giulioli,Caroline, Piau,Antoine, Bongard,Vanina, Richard,Edo, Moll van Charante,Eric P, Coley,Nicola, and Andrieu,Sandrine

Subjects
Clinical Interventions in Aging
Abstract

Laurine Andre,1,2 Caroline Giulioli,1 Antoine Piau,1,2 Vanina Bongard,1,3 Edo Richard,4,5 Eric P Moll van Charante,4,6 Nicola Coley,1,3 Sandrine Andrieu1,3 On behalf of the PRODEMOS consortium1Center for Epidemiology and Research in Population Health (CERPOP), University of Toulouse, INSERM UMR1295, UPS, Toulouse, France; 2Pole de Geriatrie, University Hospital of Toulouse, UPS, Toulouse, F-31400, France; 3Department of Epidemiology and Public Health, Toulouse University Hospital, Toulouse, France; 4Department of Public and Occupational Health, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; 5Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands; 6Department of General Practice, Amsterdam UMC, University of Amsterdam, Amsterdam, 1100DD, the NetherlandsCorrespondence: Laurine Andre, INSERM-University of Toulouse UMR1295, Pole de geriatrie, University Hospital of Toulouse, UPS, 37 allées Jules Guesde, Toulouse, F-31000, France, Tel +33562004344, Email laur.andre@hotmail.comPurpose: Dementia and cardio-metabolic diseases share many risk factors. Management of these risk factors could contribute to successful aging, including the prevention of cardio-metabolic disease and dementia. The increasing use of smartphones offers an opportunity for remote preventive interventions. We provided a systematic review of telephone and smartphone-based interventions targeting the prevention of cognitive decline, dementia cardio-metabolic diseases or their risk factors among adults aged over 50 years.Patients and Methods: We searched Pubmed and the International Clinical Trials Registry Platform for experimental studies. We used the Cochrane risk-of-bias tool (Version 2) for randomized trials or TREND (Transparent Reporting of Evaluations with Nonrandomized Designs) checklists to assess study quality for completed studies.Results: We analyzed 21 completed (3 for cognition, 18 for cardio-metabolic outcomes) and 50 ongoing studies (23 for cognition, 27 for cardio-metabolic outcomes). Smartphone interventions were used in 26 studies (3 completed, 23 ongoing). Other interventions involved telephone vocal support and text messaging. Few studies were at low risk of bias. There were heterogeneous cognitive and cardio-metabolic outcomes. The highest quality studies found no significant effects on cognition, and inconsistent results for HbA1c, blood pressure or physical activity. The lower quality-studies found effects on global cognition, working memory, memory and language and inconsistent results for clinical, biological or behavioral cardio-metabolic outcomes.Conclusion and Implications: Despite the large number of commercially available mobile health applications, the magnitude of the scientific evidence base remains very limited. Based on published studies, the added value of telephone and smartphone tools for the prevention of cardio-metabolic diseases, cognitive decline or dementia is currently uncertain, but, there are several ongoing studies expected to be completed in the coming years.Keywords: aging, telephone, smartphone, cognition, dementia, cardio, vascular outcomes

Published
2022

35. Severe Fatigue in the First Year Following SARS-CoV-2 Infection: A Prospective Cohort Study

Author

Verveen, Anouk, Wynberg, Elke, van Willigen, Hugo D. G., Boyd, Anders, de Jong, Menno D., de Bree, Godelieve, Davidovich, Udi, Lok, Anja, Moll van Charante, Eric P., Knoop, Hans, Prins, Maria, Nieuwkerk, Pythia, Agard, Ivette, Ayal, Jane, Cavdar, Floor, Craanen, Marianne, Deuring, Annemarieke, van Dijk, Annelies, Ersan, Ertan, del Grande, Laura, Hartman, Joost, Koedoot, Nelleke, Leenstra, Tjalling, Lebbink, Romy, Loomans, Dominique, Makowska, Agata, du Maine, Tom, de Man, Ilja, Matser, Amy, van der Meij, Lizenka, van Polanen, Marleen, Oud, Maria, Reid, Clark, Storey, Leeann, van Wijk, Marc, van den Aardweg, Joost, van Assem, Joyce, van Beek, Marijne, Blankert, Thyra, Dijkstra, Maartje, Figaroa, Orlane, Frenkel, Leah, van Gils, Marit, van Haga, Jelle, Han, Xiaochuan, Harskamp-Holwerda, Agnes, Hazenberg, Mette, Hidad, Soemeja, de Jong, Nina, Kootstra, Neeltje, Kuijt, Lara, Russell, Colin, van der Straten, Karlijn, van der Veen, Annelou, Verkaik, Bas, Visser, Gerben-Rienk, Graduate School, Medical Psychology, APH - Mental Health, Medical Microbiology and Infection Prevention, Infectious diseases, APH - Methodology, APH - Global Health, AII - Infectious diseases, APH - Aging & Later Life, Adult Psychiatry, ANS - Mood, Anxiety, Psychosis, Stress & Sleep, General practice, Public and occupational health, ACS - Diabetes & metabolism, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, Pulmonology, ACS - Pulmonary hypertension & thrombosis, AMS - Sports, Experimental Immunology, and Pulmonary medicine

Subjects
predictors, COVID-19, fatigue, macromolecular substances, persistence, infection
Abstract

Background: Severe fatigue can persist for months after coronavirus disease 2019 (COVID-19) onset. This longitudinal study describes fatigue severity and its determinants up to 12 months after illness onset across the full spectrum of COVID-19 severity. Methods: RECoVERED, a prospective cohort study in Amsterdam, the Netherlands, enrolled participants aged≥16 years after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnosis. Fatigue was measured using the validated Short Fatigue Questionnaire (SFQ; range 4-28) at months 1, 3, 6, 9, and 12 of follow-up. Fatigue severity was modeled over time using mixed-effects linear regression. Determinants of severe fatigue (SFQ≥18) at 6 months since illness onset (ie, persistent fatigue) were identified using logistic regression. Results: Between May 2020 and July 2021, 303 participants completed at least 1 fatigue questionnaire. Twelve months after illness onset, 17.4% (95% CI, 6.7% to 38.3%), 21.6% (95% CI, 11.2% to 37.7%), and 44.8% (95% CI, 28.0% to 62.9%) of participants with mild, moderate, and severe/critical COVID-19 (World Health Organization definition), respectively, experienced severe fatigue. When adjusting for age and sex, having≥3 comorbidities (P=.007), severe/critical COVID-19 (P=.002), low mood (P

Published
2022
Full Text
View/download PDF

44. Prospective analysis of gender-related characteristics in relation to cardiovascular disease.

Author

Bolijn, Renee, Kunst, Anton E., Appelman, Yolande, Galenkamp, Henrike, van Charante, Eric P. Moll, Stronks, Karien, Tan, Hanno L., van Valkengoed, Irene G. M., Moll van Charante, Eric P, and van Valkengoed, Irene Gm

Abstract

Objective: Differences in cardiovascular disease (CVD) incidence between men and women have been widely reported. Next to sex-related (biological) characteristics, gender-related (sociocultural) characteristics may partly explain how these differences arise. In this exploratory study, we examined the associations between selected gender-related characteristics and CVD incidence.Methods: We linked baseline data of 18 058 participants without CVD from the population-based, multiethnic HEalthy LIfe in an Urban Setting study (Amsterdam, the Netherlands) to CVD incidence data, based on hospital admission and death records from Statistics Netherlands in 2013-2018. Using Cox regression analyses, we studied associations of time spent on household work, doing home repairs, primary earner status, type of employment, working in a male-dominated or female-dominated occupation and desire for emotional support with CVD incidence, stratified by sex. Analyses were adjusted for age, ethnicity and socioeconomic status.Results: In men, gender-related characteristics were not associated with higher CVD incidence. In women, homemakers had a higher hazard for CVD compared with full-time workers (HR 2.34, 95% CI 1.35 to 4.04), whereas those spending a moderate amount of time on household work had a lower hazard for CVD than those spending little time (HR 0.56, 95% CI 0.34 to 0.95).Conclusion: Although we found no evidence for associations between gender-related characteristics and CVD incidence in men, being the homemaker and moderate time spent on household work appeared to be associated with CVD incidence in women. Thus, attention to gender-related characteristics might in future help to identify subgroups that may benefit from additional prevention strategies. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

49. Dementia incidence trend over 1992-2014 in the Netherlands: Analysis of primary care data

Author

van Bussel, Emma F., Richard, Edo, Arts, Derk L., Nooyens, Astrid C. J., Coloma, Preciosa M., de Waal, Margot W. M., van den Akker, Marjan, Biermans, Marion C. J., Nielen, Markus M. J., van Boven, Kees, Smeets, Hugo, Matthews, Fiona E., Brayne, Carol, Busschers, Wim B., van Gool, Willem A., and Moll van Charante, Eric P.

Subjects
Usage, Research, Risk factors, Demographic aspects, Medical records -- Usage -- Research, Dementia -- Analysis -- Risk factors -- Demographic aspects -- Research
Abstract

Author(s): Emma F. van Bussel 1,*, Edo Richard 2,3, Derk L. Arts 1, Astrid C. J. Nooyens 4, Preciosa M. Coloma 5, Margot W. M. de Waal 6, Marjan van [...], Background Recent reports have suggested declining age-specific incidence rates of dementia in high-income countries over time. Improved education and cardiovascular health in early age have been suggested to be bringing about this effect. The aim of this study was to estimate the age-specific dementia incidence trend in primary care records from a large population in the Netherlands. Methods and findings A dynamic cohort representative of the Dutch population was composed using primary care records from general practice registration networks (GPRNs) across the country. Data regarding dementia incidence were obtained using general-practitioner-recorded diagnosis of dementia within the electronic health records. Age-specific dementia incidence rates were calculated for all persons aged 60 y and over; negative binomial regression analysis was used to estimate the time trend. Nine out of eleven GPRNs provided data on more than 800,000 older people for the years 1992 to 2014, corresponding to over 4 million person-years and 23,186 incident dementia cases. The annual growth in dementia incidence rate was estimated to be 2.1% (95% CI 0.5% to 3.8%), and incidence rates were 1.08 (95% CI 1.04 to 1.13) times higher for women compared to men. Despite their relatively low numbers of person-years, the highest age groups contributed most to the increasing trend. There was no significant overall change in incidence rates since the start of a national dementia program in 2003 (-0.025; 95% CI -0.062 to 0.011). Increased awareness of dementia by patients and doctors in more recent years may have influenced dementia diagnosis by general practitioners in electronic health records, and needs to be taken into account when interpreting the data. Conclusions Within the clinical records of a large, representative sample of the Dutch population, we found no evidence for a declining incidence trend of dementia in the Netherlands. This could indicate true stability in incidence rates, or a balance between increased detection and a true reduction. Irrespective of the exact rates and mechanisms underlying these findings, they illustrate that the burden of work for physicians and nurses in general practice associated with newly diagnosed dementia has not been subject to substantial change in the past two decades. Hence, with the ageing of Western societies, we still need to anticipate a dramatic absolute increase in dementia occurrence over the years to come.

Published
2017
Full Text
View/download PDF

50. Diagnostic Accuracy of the Telephone Interview for Cognitive Status for the Detection of Dementia in Primary Care.

Author

Abdulrahman, Herrer, Jansen, Eva, Hoevenaar-Blom, Marieke, Willem van Dalen, Jan, van Wanrooij, Lennard L., van Bussel, Emma, van Gool, Willem A., Richard, Edo, Moll van Charante, Eric P., and van Dalen, Jan Willem

Subjects
COGNITIVE interviewing, HEALTH services administration, TELEPHONE interviewing, PRIMARY care, ELECTRONIC health records, DIAGNOSIS of dementia, COGNITION disorders, TELEPSYCHIATRY, TELEPHONES, COGNITION, PRIMARY health care, SENSITIVITY & specificity (Statistics), PSYCHOSOCIAL factors
Abstract

Purpose: Cognitive diagnostic work-up in primary care is not always physically feasible, owing to chronic disabilities and/or travel restrictions. The identification of dementia might be facilitated with diagnostic instruments that are time efficient and easy to perform, as well as useful in the remote setting. We assessed whether the Telephone Interview for Cognitive Status (TICS) might be a simple and accurate alternative for remote diagnostic cognitive screening in primary care.Methods: We administered the TICS (range, 0-41) for 810 of 1,473 older people aged 84.5 (SD, 2.4) years. We scrutinized electronic health records for participants with TICS scores ≤30 and for a random sample of participants with TICS scores >30 for a dementia diagnosis using all data from the Prevention of Dementia by Intensive Vascular Care (preDIVA) trial for 8-12 years of follow-up. We used multiple imputation to correct for verification bias.Results: Of the 810 participants, 155 (19.1%) had a TICS score ≤30, and 655 (80.9%) had a TICS score >30. Electronic health records yielded 8.4% (13/154) dementia diagnoses for participants with TICS ≤30 vs none with TICS >30. Multiple imputation for TICS >30 yielded a median of 7/655 (1.1%; interquartile range, 5-8) estimated dementia cases. After multiple imputation, the optimal cutoff score was ≤29, with mean sensitivity 65.4%, specificity 87.8%, positive predictive value 11.9%, negative predictive value 99.0%, and area under the curve 77.4% (95% CI, 56.3%-90.0%).Conclusions: In the present older population, the TICS performed well as a diagnostic screening instrument for excluding dementia and might be particularly useful when face-to-face diagnostic screening is not feasible in family practice or research settings. The potential reach to large numbers of people at low cost could contribute to more efficient medical management in primary care. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results