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12. Joint associations of peripheral artery disease and accelerometry-based physical activity with mortality: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Author

Gao, Yumin, Hua, Simin, Mok, Yejin, Salameh, Maya, Qi, Qibin, Chen, Guochong, Williams-Nguyen, Jessica, Pester, Mollie, Garcia-Bedoya, Olga, Sotres-Alvarez, Daniela, Daviglus, Martha L., Mossavar-Rahmani, Yasmin, Schrack, Jennifer A., Allison, Matthew, Kaplan, Robert, and Matsushita, Kunihiro

Published
2022
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17. Associations of psychosocial factors and cardiovascular health measured by Life's Essential 8: The Atherosclerosis Risk in Communities (ARIC) study.

Author

Peter-Marske, Kennedy M., Kucharska-Newton, Anna, Wong, Eugenia, Mok, Yejin, Palta, Priya, Lutsey, Pamela L., and Rosamond, Wayne

Subjects
PSYCHOSOCIAL factors, SLEEP quality, BODY mass index, BLOOD lipids, BLOOD sugar
Abstract

Aims: Few studies investigate whether psychosocial factors (social isolation, social support, trait anger, and depressive symptoms) are associated with cardiovascular health, and none with the American Heart Association's new definition of cardiovascular health, Life's Essential 8 (LE8). Therefore, we assessed the cross-sectional associations of psychosocial factors with Life's Essential 8 and individual components of Life's Essential 8. Methods: We included 11,311 Atherosclerosis Risk in Communities cohort participants (58% females; 23% Black; mean age 57 (standard deviation: 6) years) who attended Visit 2 (1990–1992) in this secondary data analysis using cross-sectional data from the ARIC cohort study. Life's Essential 8 components included diet, physical activity, nicotine exposure, sleep quality, body mass index, blood lipids, blood glucose, and blood pressure. Life's Essential 8 was scored per the American Heart Association definition (0–100 range); higher scores indicate better cardiovascular health. Associations of categories (high, moderate, and low) of each psychosocial factor with continuous Life's Essential 8 score and individual Life's Essential 8 components were assessed using multivariable linear regressions. Results: 11% of participants had high Life's Essential 8 scores (80–100), while 67% and 22% had moderate (50–79) and low Life's Essential 8 scores (0–49) respectively. Poor scores on psychosocial factor assessments were associated with lower Life's Essential 8 scores, with the largest magnitude of association for categories of depressive symptoms (low β = Ref.; moderate β = -3.1, (95% confidence interval: -3.7, -2.5; high β = -8.2 (95% confidence interval: -8.8, -7.5)). Most psychosocial factors were associated with Life's Essential 8 scores for diet, physical activity, nicotine, and sleep, but psychosocial factors were not associated with body mass index, blood lipids, blood glucose, or blood pressure. Conclusion: Less favorable measures of psychosocial health were associated with lower Life's Essential 8 scores compared better measures of psychosocial health among middle-aged males and females. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Universal Risk Prediction for Individuals With and Without Atherosclerotic Cardiovascular Disease.

Author

Mok, Yejin, Dardari, Zeina, Sang, Yingying, Hu, Xiao, Bancks, Michael P., Mathews, Lena, Hoogeveen, Ron C., Koton, Silvia, Blaha, Michael J., Post, Wendy S., Ballantyne, Christie M., Coresh, Josef, Rosamond, Wayne, and Matsushita, Kunihiro

Subjects
*CARDIOVASCULAR diseases, *MAJOR adverse cardiovascular events, *SECONDARY prevention, *BODY mass index
Abstract

American College of Cardiology/American Heart Association guidelines recommend distinct risk classification systems for primary and secondary cardiovascular disease prevention. However, both systems rely on similar predictors (eg, age and diabetes), indicating the possibility of a universal risk prediction approach for major adverse cardiovascular events (MACEs). The authors examined the performance of predictors in persons with and without atherosclerotic cardiovascular disease (ASCVD) and developed and validated a universal risk prediction model. Among 9,138 ARIC (Atherosclerosis Risk In Communities) participants with (n = 609) and without (n = 8,529) ASCVD at baseline (1996-1998), we examined established predictors in the risk classification systems and other predictors, such as body mass index and cardiac biomarkers (troponin and natriuretic peptide), using Cox models with MACEs (myocardial infarction, stroke, and heart failure). We also evaluated model performance. Over a follow-up of approximately 20 years, there were 3,209 MACEs (2,797 for no prior ASCVD). Most predictors showed similar associations with MACE regardless of baseline ASCVD status. A universal risk prediction model with the predictors (eg, established predictors, cardiac biomarkers) identified by least absolute shrinkage and selection operator regression and bootstrapping showed good discrimination for both groups (c-statistics of 0.747 and 0.691, respectively), and risk classification and showed excellent calibration, irrespective of ASCVD status. This universal prediction approach identified individuals without ASCVD who had a higher risk than some individuals with ASCVD and was validated externally in 5,322 participants in the MESA (Multi-Ethnic Study of Atherosclerosis). A universal risk prediction approach performed well in persons with and without ASCVD. This approach could facilitate the transition from primary to secondary prevention by streamlining risk classification and discussion between clinicians and patients. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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25. Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data

Author

Chalmers, John, Arima, Hisatomi, Perkovic, Vlado, Grams, Morgan E., Sang, Yingying, Schaeffner, Elke, Martus, Peter, Levin, Adeera, Djurdjev, Ognjenka, Tang, Mila, Heine, Gunnar, Seiler, Sarah, Zawada, Adam, Emrich, Insa, Sarnak, Mark, Katz, Ronit, Brenner, Hermann, Schöttker, Ben, Rothenbacher, Dietrich, Saum, Kai-Uwe, Köttgen, Anna, Schneider, Markus, Eckardt, Kai-Uwe, Green, Jamie, Kirchner, H Lester, Chang, Alex R, Black, Corri, Marks, Angharad, Prescott, Gordon, Clark, Laura, Fluck, Nick, Jee, Sun Ha, Mok, Yejin, Chodick, Gabriel, Shalev, Varda, Wetzels, Jack F.M., Blankestijn, Peter J, van Zuilen, Arjan D, Bots, M, Peralta, Carmen, Hiromoto, Jade, Bottinger, Erwin, Nadkarni, Girish N, Ellis, Stephen B, Nadukuru, Rajiv, Kenealy, Timothy, Elley, C Raina, Collins, John F, Drury, Paul L, Bakker, Stephan JL, Heerspink, Hiddo J Lambers, Jassal, Simerjot K, Bergstrom, Jaclyn, Ix, Joachim H, Barrett-Connor, Elizabeth, Kalantar-Zadeh, Kamyar, Carrero, Juan J, Gasparini, Alessandro, Qureshi, Abdul Rashid, Barany, Peter, Algra, Ale, van der Graaf, Yolanda, Evans, Marie, Segelmark, Mårten, Stendahl, Maria, Schön, Staffan, Tangri, Navdeep, Sud, Maneesh, Naimark, David, Lannfelt, Lars, Larsson, Anders, Hallan, Stein, Levey, Andrew S, Chen, Jingsha, Kwak, Lucia, Matsushita, Kunihiro, Ballew, Shoshana H, Coresh, Josef, Ärnlöv, Johan, Cirillo, Massimo, Ebert, Natalie, Hiramoto, Jade S, Kimm, Heejin, Shlipak, Michael G, Visseren, Frank L J, Gansevoort, Ron T, Kovesdy, Csaba P, Woodward, Mark, and Kronenberg, Florian

Published
2017
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27. A Meta-analysis of the Association of Estimated GFR, Albuminuria, Diabetes Mellitus, and Hypertension With Acute Kidney Injury

Author

Tonelli, Marcello, Hemmelgarn, Brenda R., James, Matthew T., Turin, Tanvir Chowdhury, Coresh, Josef, Matsushita, Kunihiro, Grams, Morgan, Sang, Yingying, Shlipak, Michael, Sarnak, Mark J., Katz, Ronit, Wheeler, David C., Emberson, Jonathan, Landray, Martin J., Townend, Jonathan N., Green, Jamie, Kirchner, H. Les, Perkins, Robert, Chang, Alex R., Romundstad, Solfrid, Aasarød, Knut, Øien, Cecilia M., Hallan, Stein, Smith, David H., Thorp, Micah L., Johnson, Eric S., Chodick, Gabriel, Herzel, Esma, Katz, Rachel, Shalev, Varda, Gansevoort, Ron T., Bakker, Stephan J.L., Lambers Heerspink, Hiddo J., van der Harst, Pim, Jee, Sun Ha, Kimm, Heejin, Mok, Yejin, Tangri, Navdeep, Naimark, David, Ärnlöv, Johan, Larsson, Anders, Lannfelt, Lars, Kovesdy, Csaba P., Kalantar-Zadeh, Kamyar, de Jong, Paul E., Iseki, Kunitoshi, Levey, Andrew S., Stengel, Benedicte, Warnock, David, Woodward, Mark, Ballew, Shoshana H., Grams, Morgan E., Elley, C. Raina, Green, Jamie A., de Jong, Paul, and Warnock, David G.

Published
2015
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28. A Meta-analysis of the Association of Estimated GFR, Albuminuria, Age, Race, and Sex With Acute Kidney Injury

Author

Tonelli, Marcello, Hemmelgarn, Brenda R., James, Matthew T., Turin, Tanvir Chowdhury, Coresh, Josef, Matsushita, Kunihiro, Grams, Morgan, Sang, Yingying, Shlipak, Michael, Sarnak, Mark J., Katz, Ronit, Wheeler, David C., Emberson, Jonathan, Landray, Martin J., Townend, Jonathan N., Green, Jamie, Kirchner, H. Les, Perkins, Robert, Chang, Alex R., Romundstad, Solfrid, Aasarød, Knut, Øien, Cecilia M., Hallan, Stein, Smith, David H., Thorp, Micah L., Johnson, Eric S., Chodick, Gabriel, Herzel, Esma, Katz, Rachel, Shalev, Varda, Gansevoort, Ron T., Bakker, Stephan J.L., Lambers Heerspink, Hiddo J., van der Harst, Pim, Jee, Sun Ha, Kimm, Heejin, Mok, Yejin, Tangri, Navdeep, Naimark, David, Ärnlöv, Johan, Larsson, Anders, Lannfelt, Lars, Kovesdy, Csaba P., Kalantar-Zadeh, Kamyar, de Jong, Paul E., Iseki, Kunitoshi, Levey, Andrew S., Stengel, Benedicte, Warnock, David, Woodward, Mark, Ballew, Shoshana H., Grams, Morgan E., and Oien, Cecilia

Published
2015
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31. Abstract 15450: International Validation of the TIMI Risk Score for Secondary Prevention in Post-MI Patients: A Collaborative Analysis of the Chronic Kidney Disease Prognosis Consortium and the Risk Validation Scientific Committee

Author

Mok, Yejin, Ballew, Shoshana, Bhatt, Deepak L, Boden, William E, Bonaca, Marc P, Carrero, Juan-Jesus, Coresh, Josef, Elley, C. Raina, Fowkes, Gerry R, Jee, Sun Ha, Kovesdy, Csaba, Mahaffey, Kenneth W, Nadkarni, Girish, Sang, Yingying, and Matsushita, Kunihiro

Published
2017

40. Clinically Recognized Varicose Veins and Physical Function in Older Individuals: The ARIC Study.

Author

Mok, Yejin, Ishigami, Junichi, Sang, Yingying, Kucharska-Newton, Anna M, Salameh, Maya, Schrack, Jennifer A, Palta, Priya, Coresh, Josef, Windham, B Gwen, Lutsey, Pamela L, Folsom, Aaron R, and Matsushita, Kunihiro

Subjects
*CROSS-sectional method, *DISEASE incidence, *VARICOSE veins, *RESEARCH funding, *PROPORTIONAL hazards models
Abstract

Background: Although a few studies reported an association between varicose veins and physical function, this potentially bidirectional association has not been systematically evaluated in the general population.Method: In 5 580 participants (aged 71-90 years) from the Atherosclerosis Risk in Communities study, varicose veins were identified in outpatient and inpatient administrative data prior to (prevalent cases) and after (incident cases) visit 5 (2011-2013). Physical function was evaluated by the Short Physical Performance Battery (SPPB, score ranging from 0 to 12). We evaluated (i) cross-sectional association between prevalent varicose veins and physical function, (ii) association of prevalent varicose veins with subsequent changes in physical function from visit 5 to visits 6 (2016-2017) and 7 (2018-2019), and (iii) association of physical function at visit 5 with incident varicose veins during a median follow-up of 3.6 years (105 incident varicose veins among 5 350 participants without prevalent cases at baseline).Results: At baseline, varicose veins were recognized in 230 (4.1%) participants and cross-sectionally associated with reduced physical function. Longitudinally, prevalent varicose veins were not significantly associated with a decline in SPPB over time. In contrast, a low SPPB ≤6 was associated with a greater incidence of varicose veins compared to SPPB ≥10 (adjusted hazard ratio 2.13 [95% confidence interval = 1.19, 3.81]).Conclusion: In community-dwelling older adults, varicose veins and low physical function were associated cross-sectionally. Longitudinally, low physical function was a risk factor for incident varicose veins, but not vice versa. Our findings suggest an etiological contribution of low physical function to incident varicose veins. [ABSTRACT FROM AUTHOR]

Published
2022
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41. The Korean Heart Study: rationale, objectives, protocol, and preliminary results for a new prospective cohort study of 430,920 men and women

Author

Jee, Sun Ha, Batty, David G, Jang, Yangsoo, Oh, Dong Joo, Oh, Byung-Hee, Lee, Sang Hoon, Park, Seong-Wook, Seung, Ki-Bae, Kimm, Heejin, Kim, Sang Yeun, Mok, Yejin, Kim, Hyon-Suk, Lee, Duk Chul, Choi, Sung Hee, Kim, Moon Jong, Lee, Gyu Jang, Sung, Jidong, Cho, BeLong, Kim, Eung Soo, Yu, Byung-Yeon, Lee, Tae-Yong, Kim, Jong Sung, Lee, Yong-Jin, Oh, Jang-Kyun, Kim, Sung Hi, Park, Jong-Ku, Koh, Sang Baek, Park, Sat Byul, Lee, Soon Young, Yoo, Cheol-In, Kim, Moon Chan, Kim, Hong-Kyu, Park, Joo-sung, Yun, Young Duk, Baek, Soo Jin, Samet, Jonathan M, and Woodward, Mark

Published
2014
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42. Periodontal disease measures and risk of incident peripheral artery disease: The Atherosclerosis Risk in Communities (ARIC) Study.

Author

Arsiwala, Lubaina T., Mok, Yejin, Yang, Chao, Ishigami, Junichi, Selvin, Elizabeth, Beck, James D., Allison, Matthew A., Heiss, Gerardo, Demmer, Ryan T., and Matsushita, Kunihiro

Abstract

Background: The association of periodontal disease with atherosclerotic cardiovascular diseases is well known, but not specifically with incident peripheral artery disease (PAD). Therefore, we studied the associations of periodontal disease with incident PAD in a population-based setting.Methods: Among 9,793 participants (aged 53-75 years) without prevalent PAD, self-reported history of periodontal disease was ascertained. Of these, 5,872 participants underwent full-mouth examinations from which periodontal status was defined using the US Centers for Disease Control and Prevention-American Academy of Periodontology (CDC-AAP) definition. We quantified the association of periodontal disease with incident PAD (defined by hospital admission diagnosis or procedures) using multivariable Cox regression models.Results: During a median follow-up of 20.1 years, 360 participants (3.6%) developed PAD. In models accounting for potential confounders including diabetes and smoking pack-years, there was higher hazard of PAD in participants with self-reported tooth loss because of periodontal disease (hazard ratio:1.54 [95% CI:1.20-1.98]), history of periodontal disease treatment (1.37 [1.05-1.80]), and periodontal disease diagnosis (1.38 [1.09-1.74]), compared to their respective counterparts. The clinical measure of periodontal disease (n = 5,872) was not significantly associated with incident PAD in the fully adjusted model (e.g., 1.53 [0.94-2.50] in CDC-AAP-defined severe periodontal disease versus no disease).Conclusion: We observed a modest association of self-reported periodontal disease, especially when resulting in tooth loss, with incident PAD in the general population. Nonetheless, a larger study with the clinical measure of periodontal disease is warranted. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Albuminuria, Kidney Function, and Cancer Risk in the Community.

Author

Mok, Yejin, Ballew, Shoshana H, Sang, Yingying, Coresh, Josef, Joshu, Corinne E, Platz, Elizabeth A, and Matsushita, Kunihiro

Subjects
*KIDNEY physiology, *TUMOR risk factors, *ALBUMINURIA, *GLOMERULAR filtration rate, *REGRESSION analysis, *RISK assessment, *TUMORS, *DISEASE incidence, *CONFOUNDING variables
Abstract

Few studies have comprehensively investigated the association of 2 key kidney disease measures, estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (ACR), with cancer incidence. In 8,935 participants at the baseline (1996–1998) from the Atherosclerosis Risk in Communities study, we quantified the associations of eGFR (based on creatinine and cystatin C) and ACR with cancer risk using Cox regression models adjusted for potential confounders. Due to changing guidelines for prostate cancer screening during the follow-up period, we investigated overall cancer, overall nonprostate cancer, and site-specific cancer. During a median follow-up of 14.7 years, 2,030 incident cancer cases occurred. In demographically adjusted models, low eGFR and high ACR were associated with cancer incidence (both overall and overall nonprostate cancer). These associations were attenuated after adjusting for other shared risk factors, with a significant association remaining only for ACR (≥103 compared with 5 mg/g) and overall nonprostate cancer. For site-specific cancer, only high ACR showed a significant association with lung and urinary tract cancers. Of these, the association between ACR and lung cancer appeared most robust in several sensitivity analyses. Kidney disease measures, particularly high ACR, were independently associated with cancer risk. The association between ACR and lung cancer was uniquely robust, warranting future studies to explore potential mechanisms. [ABSTRACT FROM AUTHOR]

Published
2020
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48. Premorbid levels of high-sensitivity cardiac troponin T and natriuretic peptide and prognosis after incident myocardial infarction.

Author

Mok, Yejin, Sang, Yingying, Ballew, Shoshana H., Hoogeveen, Ron C., Ballantyne, Christie M., Rosamond, Wayne, Coresh, Josef, Selvin, Elizabeth, and Matsushita, Kunihiro

Abstract

High-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) at the time of myocardial infarction (MI) are strong predictors of prognosis. However, whether their premorbid (before MI occurrence) levels are associated with prognosis after incident MI is unknown.Methods: In 1,054 participants from the Atherosclerosis Risk in Communities Study with incident MI, we evaluated premorbid levels of hs-cTnT and NT-proBNP measured on median 5.8 (interquartile interval 3.0-11.5 [mean 5.5]) years prior to incident MI and their associations with subsequent composite and individual outcomes of all-cause mortality, cardiovascular mortality, recurrent MI, heart failure, and stroke.Results: During a median follow-up of 3.0 years after MI, 801 participants developed the composite outcome. Both hs-cTnT and NT-proBNP were independently associated with the composite outcome after incident MI. Among individual outcomes, all-cause mortality, cardiovascular mortality, and heart failure showed significant associations with both cardiac markers. Overall, NT-proBNP demonstrated a more evident relationship than hs-cTnT. Indeed, the addition of premorbid NT-proBNP alone, but not hs-cTnT alone, to conventional predictors at incident MI significantly improved risk prediction of the composite outcome after incident MI (Δc-statistic 0.013 [95% CI 0.005-0.022] from 0.691 with conventional predictors).Conclusions: Premorbid levels of hs-cTnT and NT-proBNP assessed on average 6 years prior to incident MI were associated with adverse outcomes after incident MI. These results further highlight the importance of cardiac health at an earlier stage of life. [ABSTRACT FROM AUTHOR]

Published
2019
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