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1. Staphylococcus capitis isolated from bloodstream infections: a nationwide 3-month survey in 38 neonatal intensive care units

Author

Decalonne, Marie, Dos Santos, Sandra, Gimenes, Rémi, Goube, Florent, Abadie, Géraldine, Aberrane, Saïd, Ambrogi, Vanina, Baron, Raoul, Barthelemy, Patrick, Bauvin, Isabelle, Belmonte, Olivier, Benabid, Emilie, Ammar, Rafik Ben, Yahia, Salma Ben Hadj, Berrouane, Yasmina, Berthelot, Philippe, Beuchee, Alain, Bille, Emmanuelle, Bolot, Pascal, Bordes-Couecou, Stéphanie, Bouissou, Antoine, Bourdon, Sandra, Bourgeois-Nicolaos, Nadège, Boyer, Sophie, Cattoen, Christian, Cattoir, Vincent, Chaplain, Chantal, Chatelet, Céline, Claudinon, Aurore, Chautemps, Nathalie, Cormier, Hélène, Coroller-Bec, Céline, Cotte, Benjamin, De Chillaz, Carole, Dauwalder, Olivier, Davy, Aude, Delorme, Martine, Demasure, Maryvonne, Desfrere, Luc, Drancourt, Michel, Dupin, Clarisse, Faraut-Derouin, Véronique, Florentin, Arnaud, Forget, Virginie, Fortineau, Nicolas, Foucan, Tania, Frange, Pierre, Gambarotto, Karine, Gascoin, Géraldine, Gibert, Laure, Gilquin, Jacques, Glanard, Audrey, Grando, Jacqueline, Gravet, Alain, Guinard, Jérôme, Hery-Arnaud, Geneviève, Huart, Claire, Idri, Nadia, Jellimann, Jean-Marc, Join-Lambert, Olivier, Joron, Sylvie, Jouvencel, Philippe, Kempf, Marie, Ketterer-Martinon, Sophie, Khecharem, Mouna, Klosowski, Serge, Labbe, Franck, Lacazette, Adeline, Lapeyre, Fabrice, Larche, Jérôme, Larroude, Peggy, Le Pourhiennec, Anne, Le Sache, Nolwenn, Ledru, Sylvie, Lefebvre, Annick, Legeay, Clément, Lemann, Florence, Lesteven, Claire, Levast-Raffin, Marion, Leyssene, David, Ligi, Isabelle, Lozniewski, Alain, Lureau, Pierre, Mallaval, Franck-Olivier, Malpote, Edith, Marret, Stéphane, Martres, Pascale, Menard, Guillaume, Menvielle, Laura, Mereghetti, Laurent, Merle, Véronique, Minery, Pascale, Morange, Virginie, Mourdie, Julien, Muggeo, Anaelle, Nakhleh, Jean, Noulard, Marie-Noëlle, Olive, Claude, Patural, Hugues, Penn, Pascale, Petitfrere, Manuel, Pozetto, Bruno, Riviere, Brigitte, Robine, Audrey, Ceschin, Christine Roques, Ruimy, Raymond, Siali, Amine, Soive, Stéphanie, Slimani, Souad, Trentesaux, Anne-Sophie, Trivier, Dominique, Vandenbussche, Christian, Villeneuve, Laurent, Werner, Evelyne, Le Vu, Stéphane, and Van Der Mee-Marquet, Nathalie

Published
2020
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2. Computer Reading Rate Course for College Students?

Author

Minery, Bonnie

Abstract

A study examined the influence of the computer management feature of a commercially prepared speed reading software package on the reading rate and attitudes of college students towards computers as instructional tools. Subjects, 66 college freshman from lower-middle to middle socio-economic brackets (and divided into control and experimental groups) enrolled in the College Reading and Rate Improvement Course of William Paterson College, had borderline reading comprehension scores on standardized tests. Both groups used the Sack-Yourman Speed Reading Course, with the experimental group using the computer program to calculate their reading rates and comprehension scores. Results indicated that both groups made gains in reading efficiency, but that the experimental group using the computer management features made greater gains despite negative attitudes produced by troublesome computers and a mid-course change of instructor. (Four tables of data are included, and 34 references and two survey instruments are attached.) (RS)

Published
1988

3. Influenza outbreaks management in a French psychiatric hospital from 2004 to 2012.

Author

Gaspard P, Mosnier A, Gunther D, Lochert C, Larocca S, Minery P, Stoll-Keller F, Bertrand X, and Talon D

Subjects
Adult, Aged, Antiviral Agents therapeutic use, France epidemiology, Humans, Influenza, Human diagnosis, Influenza, Human therapy, Masks, Middle Aged, Protective Clothing, Cross Infection prevention & control, Disease Outbreaks prevention & control, Hospitals, Psychiatric, Infection Control methods, Influenza Vaccines therapeutic use, Influenza, Human epidemiology
Abstract

Objective: Influenza epidemics can have consequences in terms of morbidity and mortality for the patients. This work assesses influenza outbreaks in order to validate and optimize alert and control measures in a psychiatric hospital., Method: The prospective monitoring of influenza episodes was conducted for 8 years in 19 units of a mental health hospital. Rapid influenza diagnostic tests were used. The study of the episodes with confirmed influenza cases was carried out., Results: Influenza monitoring and alert were essential with information and laboratory-confirmed cases. Influenza was common with a total of 20 episodes for the studied period. A maximum of 25% (5/20) of the units were affected in 2008-2009. Rapid influenza diagnostic tests allowed a quick identification with an average time of 1.5 days. Mainly, control measures limited the spread of the influenza virus in units with patient not at high risk of complications. On the other hand, antiviral curative treatment and chemoprophylaxis are essential in units with patients at high risk of complications., Conclusion: In a psychiatric hospital, influenza management has to take into account the exposed patient's risks for influenza complications and to adapt the strategy according to the risks identified., (Copyright © 2014 Elsevier Inc. All rights reserved.)

Published
2014
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4. The polymorphic cytochrome P-4502D6 is involved in the metabolism of both 5-hydroxytryptamine antagonists, tropisetron and ondansetron.

Author

Fischer V, Vickers AE, Heitz F, Mahadevan S, Baldeck JP, Minery P, and Tynes R

Subjects
Animals, CHO Cells, Cells, Cultured, Chromatography, High Pressure Liquid, Cricetinae, Cyclosporine pharmacokinetics, Cyclosporine pharmacology, Cytochrome P-450 CYP2D6, Cytochrome P-450 Enzyme Inhibitors, Humans, Hydroxylation, In Vitro Techniques, Indoles pharmacology, Liver drug effects, Liver enzymology, Microsomes, Liver drug effects, Microsomes, Liver enzymology, Microsomes, Liver metabolism, Mixed Function Oxygenases antagonists & inhibitors, Ondansetron pharmacology, Spectrometry, Mass, Fast Atom Bombardment, Tropisetron, Cytochrome P-450 Enzyme System metabolism, Indoles pharmacokinetics, Mixed Function Oxygenases metabolism, Ondansetron pharmacokinetics, Serotonin Antagonists pharmacokinetics
Abstract

Tropisetron and ondansetron, which are potent and selective 5-hydroxytryptamine (5-HT3) receptor antagonists, were both metabolized by human liver microsomes to several metabolites. These metabolites include the major metabolites found in humans, which are the 5-, 6-, and 7-hydroxy tropisetron and the 7- and 8-hydroxy ondansetron. The cytochrome P-450 (CYP) 2D6 inhibitor quinidine (1 microM) reduced the hydroxylation of tropisetron (67%) and ondansetron (18%). Confirmation of CYP2D6 involvement in the hydroxylation of tropisetron and ondansetron was obtained by the formation of these metabolites in recombinant V79 cells expressing human CYP2D6. The CYP3A substrate/inhibitor, cyclosporine A (CsA) had little effect on tropisetron hydroxylation (< 10%), whereas CsA and triacetyloleandomycin reduced ondansetron 7- and 8-hydroxylation up to 27%. Substrates for CYP1A (phenacetin and acetanilide), CYP2C (mephenytoin), and CYP2E (chlorzoxazone) had negligible inhibitory effects on the hydroxylation of either tropisetron or ondansetron. For the CYP2D6-dependent O-demethylation of dextromethorphan, tropisetron and ondansetron were competitive inhibitors with Ki values of 14 and 29 microM, respectively. The CYP3A specific metabolism of CsA was also competitively inhibited by tropisetron (Ki = 2.1 mM) and ondansetron (Ki = 31 microM). Other metabolites, which are only minor in vivo were also inhibited by CsA, 47-60% for tropisetron metabolism and 43% for ondansetron metabolism. To summarize, this study has identified the involvement of CYP2D6 in the formation of the hydroxylated metabolites of tropisetron and ondansetron and in addition of CYP3A in ondansetron hydroxylation. Because these are the major pathways in vivo, coadministration of drugs competing for CYP2D6 and possibly CYP3A4 could influence the human kinetics of tropisetron and ondansetron.

Published
1994

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