7 results on '"Middleditch, Alexander"'
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2. Discontinuation vs. continuation of renin–angiotensin system inhibition before non-cardiac surgery: the SPACE trial.
- Author
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Ackland, Gareth L, Patel, Akshaykumar, Abbott, Tom E F, Begum, Salma, Dias, Priyanthi, Crane, David R, Somanath, Sameer, Middleditch, Alexander, Cleland, Stuart, Arroyo, Ana Gutierrez del, Brealey, David, Pearse, Rupert M, and investigators, the Stopping Perioperative ACE-inhibitors or angiotensin-II receptor blockers (SPACE) trial
- Subjects
RENIN-angiotensin system ,ANGIOTENSIN-receptor blockers ,MYOCARDIAL injury - Abstract
Background and Aims Haemodynamic instability is associated with peri-operative myocardial injury, particularly in patients receiving renin–angiotensin system (RAS) inhibitors (angiotensin-converting-enzyme inhibitors/angiotensin II receptor blockers). Whether stopping RAS inhibitors to minimise hypotension, or continuing RAS inhibitors to avoid hypertension, reduces peri-operative myocardial injury remains unclear. Methods From 31 July 2017 to 1 October 2021, patients aged ≥60 years undergoing elective non-cardiac surgery were randomly assigned to either discontinue or continue RAS inhibitors prescribed for existing medical conditions in six UK centres. Renin–angiotensin system inhibitors were withheld for different durations (2–3 days) before surgery, according to their pharmacokinetic profile. The primary outcome, masked to investigators, clinicians, and patients, was myocardial injury [plasma high-sensitivity troponin-T (hs-TnT) ≥ 15 ng/L within 48 h after surgery, or ≥5 ng/L increase when pre-operative hs-TnT ≥15 ng/L]. Pre-specified adverse haemodynamic events occurring within 48 h of surgery included acute hypertension (>180 mmHg) and hypotension requiring vasoactive therapy. Results Two hundred and sixty-two participants were randomized to continue (n = 132) or stop (n = 130) RAS inhibitors. Myocardial injury occurred in 58 (48.3%) patients randomized to discontinue, compared with 50 (41.3%) patients who continued, RAS inhibitors [odds ratio (for continuing): 0.77; 95% confidence interval (CI) 0.45–1.31]. Hypertensive adverse events were more frequent when RAS inhibitors were stopped [16 (12.4%)], compared with 7 (5.3%) who continued RAS inhibitors [odds ratio (for continuing): 0.4; 95% CI 0.16–1.00]. Hypotension rates were similar when RAS inhibitors were stopped [12 (9.3%)] or continued [11 (8.4%)]. Conclusions Discontinuing RAS inhibitors before non-cardiac surgery did not reduce myocardial injury, and could increase the risk of clinically significant acute hypertension. These findings require confirmation in future studies. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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3. Cancelled operations: a 7-day cohort study of planned adult inpatient surgery in 245 UK National Health Service hospitals
- Author
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Moonesinghe, S. Ramani, Wong, Danny J.N., Harris, Steve K., Bedford, James, Boney, Oliver, Chazapis, Maria, Drake, Sharon, Farmer, Laura, Gilhooly, David, Goodwin, James, Lourtie, Jose, Wagstaff, Duncan, Grocott, Mike, Sneyd, Robert, Batchelor, Anna, Brett, Stephen, Plowright, Catherine, Shrestha, Suman, Shawyer, Richard, Ahmed, Shafi, Khondoker, Mizan, Nathanson, Mike, Cripps, Paul, Research & Audit Federation of Trainees (RAFT), Anaesthetic Audit and Research Matrix of Yorkshire (AARMY), Intensive Care & Anaesthesia Research Network of North East Trainees (INCARNNET), Merseyside Anaesthetic Group for Improving Quality (MAGIQ), Midlands East Research by Critical Care and Anaesthetic Trainees (MERCAT), North West Research and Audit Group (NWRAG), Oxford Critical Care Anaesthetic Research Enterprise (OxCCARE), Pan-London Peri-operative Audit & Research Network (PLAN), Scottish East Quality Improvement & Research Academy (SEQuoIA), SESSA Quality Improvement and Research Network (SQUARES), Severn Trainees Anaesthetic Research (STAR), South West Anaesthetic Research Matrix (SWARM), South Yorkshire Hospitals Audit and Research Collaboration (SHARC), Southcoast Peri-operative Audit and Research Collaboration (SPARC), Welsh Anaesthetic Audit Research & Engagement Network (WAAREN), West Midlands Trainee Research Anaesthesia & Intensive Care Network (WMTRAIN), Rawat, Shilpa, Sathe, Sonia, Campbell, Alison, Anandarajah, Janakan, Ball, Nicola, Bandara, Lalindra, Barnes, Dennis, Chapman, Catherine, Connor, Lynda, Cook, Amanda, Ebejer, Amanda, Evans, Samantha, Gallagher, Maire, Goff, Sarah, Halfacree, Irina, Harford, Rachel, Harris, Catherine, Jackson, Rebecca, James, Kathryn, Jones, Claire, Jones, Sharon, Malinovszky, Kathy, Mungai, Serah, Nageswaran, Hari, Perumal, Anand, Pudge, Harriet, Quinn, Leanne, Sheppard, Thomas, Smith, Trudy, Spargo, James, Storton, Sharon, Thomas, Caradog, Thomas, Charlotte, Tyrrell, Samuel, Vale, Owen, Williams, Catrin, Williams, Marie, Williams, Tom, Winfield-Young, Lewys, Worrell, Helen, Moloney, Dermot, Chuni, Chandini, Comara, Jasna, Conway, Brian, Eagle, Zara, Foster, Greg, Platt, Chris, Thorne, Alison, Hee, Wendy Lum, Armstrong, Lisa, Brennan, Albert, Burns, Justine, Busby, Chantal, Couch-Upite, Mechele, Dooks, Emma, Dunlop, Sally, Eijk, Anya, Govindaraju, Ramana, Gregory, Tamsin, Grover, Alka, Hairsine, Brigid, Hennell, Sarah, Hill, Philippa, Hollins, Thomas, Hood, Julian, Horner, Lisa, Hothersall, Helen, Ingham, Rachel, Jackson, Richard, Kitching, Amy, Kurasz, Claire, Munsie, Sarah, Nemeth, Ildiko, Paley, Carole, Premraj, Prabhakaran, Redhead, Sue, Scriven, John, Shaw, Alison, Shenton, Liz, Shiva, Hemantha, Snell, Josie, Sootheran, Lucy, Stewart, Josephine, Swinton, Frank, Totten, Claire, Varghese, Liz, Vest, Sarah, Wetherell, Ben, Hamlyn, Vincent, Tozer, James, Alce, Timothy, Bopanna, Poonam, Draper, Kevin, Emmett, Lucy, Falkner, Phillippa, Fisher, Ellie, Griffiths, Cat, Gunter, Una, Harris, Rebecca, Hashmi, Saima, Jewitt, 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Nagaratnam, Vidhya, Mukherjee, Smitangshu, Kirby, Sue, Arnold, Glenn, Bendel, Daniel, Boynton, Claire, Carvell, James, Carver, Anthony, Clayton, Matt, Desai, Keyury, Fadhlillah, Fiqry, Georgiou, Christiana, Jayakumar, Vineetha, Jeanes, Lara, Jhugursing, Mhairi, Jose, Jasmine, Karsten, Emma, Kormendy, Flora, Lewis, Stephanie, Lloyd, Dafydd, Mautadin, Francisca, McCahill, Claire, McInerney, Susan, Morland, Laura, Morsman, Elaine, Nayee, Sunny, O'Callaghan, David, Pickford, Emily, Pratap, Bhavesh, Rao, Chandana, Shah, Alka, Smith, Stephen, Smyth, Claire, Souleimanova, Icel, Templeton, Maie, Upadhyaya, Kavita, Uren, Sophie, Voralia, Shree, Wilson, Rebecca, Kushakavsky, Vlad, Ang, Justin, Beeby, Debroah, Bell, Stephanie, Boys, Helen, Brixey, Sue, Chabo, Cathleen, Cubitt, Lynsey, Dawson, Maggie, Finch, Jenny, Lewis, Robert, Purewal, Bally, Pyae, Kaung, Ramsey, Judi, Scoones, Ben, Debreceni, Gabor, Tarin, Obaid, Zondo, Nicola, Bothma, Pieter, Carmichael, Jack, Ferreira, Teresa, Goffin, Kelly, Gurung, Sarada, Kundu, Ashish, MacLennan, Sarah, Murray, Theresa, Verma, Karan, Wilson, Graeme, Winthein, Aleinmar, Jakkampudi, Satyanarayan, Ahmed, Muneeba, Baines, Duncan, Beirnes, Charmaine, Braybrook, Chrissy, Fernandez, Olga, Gracey, Jayshree, Guha, Snehasish, Jain, Arihant, Krishnaiyan, Raghavendran, Moody, Thomas, Novaga, Jo, Tait, Frances, Tate, Jemma, Taylor, Jennifer Claire, Waldron, Molly, White, Sonia, Gupta, Anish, Botfield, Claire, Ahmed, Mohamed, Ashton, Lizzie, Bailey, Andrew Robert, Banugo, Pele, Birch, Sian, Boyle, Henry, Brown, Alice, Chen, Mark, Connolly, Lucy, Dalal, Viral, Edwards, Alexandra, Elnour, Shaima, Faccini, Timothy, Floyd, Theodore, Georgiou, Thomas, Gill, James, Hedley, Russell, Hopkins, Philip, Kumar, Roshmi, Michell, Alice, O'Shaughnessy, Rhiann Marie, O'Sullivan, Laura, Pai, Seema, Parsons, Benjamin, Peltola, Laura, Penhaligan, Beth, Place, Merate, Ramsden, Jonathan, Ratnayake, Gamunu, Shammas, Kathy, Watts, Ali, Williams, Thomas, Woodham, Valantine, Puranik, Sarang, Crooks, Jennifer, Dean, Ania, Honstvet, Chris, Hunter, Katherine, Steynberg, Sarah, Swain, Andrew, Laha, Shondipon, Bonner, Alex, Doyle, Donna, Fallon, Robert, Verlander, Mark, Williams, Alexandra, Yardley, Richard, Whiteley, Simon, Ahmed, Zaid, Child, Ossian Aukland, Black, Sheila, Calderwood, Jamie, Chapman, Andy, Collin, Robert, Dwornik, Kinga, Gallagher, Kate, Gardener, Michelle, Harrop, Gareth, Hart, Peter, Howcroft, Clare, Ilyas, Carl, Kempanna, Umakanth, Krishnamurthy, Gnanshree, Kumara, Paramesh, Loh, LI Lian, Morgan, James, Pipe, Jonathan, Sathiapillai, Anand, Stones, John, Wilby, Elizabeth, Shephard, Buzz, Agarwal, Manju, Bolonenkova, Tatyana, Dunlop, Lisa, Duraisamy, Karthick, Kelly, Jenna, Nurmi, Eveliina, Patel, Mitul, Perry, Jonathan, Prior, Charles, Reece-Anthony, Rosie, Rose, Bernd Oliver, Rowland, Katie, Van Ross, Jennifer, McNamara, Helen, Permall, Natasha, Robertson, Gillian, Siew, Sarah, Smith, Amy, Spearritt, Sue, Verma, Dipali, Williams, Rhys, Zaidi, Suhail, Clayton, Samantha, Goddin, James, Joy, Stuart, Malhotra, Vikram, Mindel, Samuel, Neilson, Zoe, Wijesuria, Shanelle Tharuka, Wilkins, Ryan, Mukherjee, Kirtida, Bradley, Andrew, Coetzee, Samantha, Crook, Alexandra, Emeakaroha, Eunice, Frenkiel, Marek, Hatton, Tom, Kamraj, Kootharajan, Long, Natalie, Manikundalam, Badrinath, Peiris, Muditha, Roche, Matthew, Sandhu, Banher, White, Nichola, Woods, Annette, Yarnold, Adam, Price, Nicolas, Ashe, Marion, Disney, Tom, Dixon, Caroline, Dodds, Emily, El-Sheika, Sarah, Hameed, Yasir, Jones, Rob, Kanal, Karan, Ranaweera, Sanjeewa, Ripoll, Simon, Russell, Nicki, Smith, Sally Anne, Tung, Swee Ang, Emerson, Bruce, Apps, Victoria, Austin, Mandy, Catchpole, Laura, Catley, Christine, Child, Jenny, Cranmer, Karen, Dawson, Lizzie, Farr, Beth, Gerrish, Helen, Gibson, Sian, Gunn, Jacqueline, Holland, Kim, James, Lorri, Jayasekera, Dushyanthi, Lester, Yvonne, Lyle, Amanda, McNeela, Fiona, Oborska, Aneta, Pennington, James, Perkins, Lauren, Robinson-Perrie, Hollie, Shillito, Lauren, Singizi, Bryan, Smolen, Susan, Topliffe, Joanne, Vowles, Ben, Whybro, Natalie, Wijunamai, Amon, Willsher, Lucy, Wootton, Joanne, Varma, Sandeep, Atkinson, Philip, Buckley, Sarah, Darian, Thelma, Dhamaratne, Sachini, Gould, Richard, Graham, Laura, Hirst, Charlotte, Peeling, Andrew, Prentice, Saxon, Rajasekar, Naresh, Rose, Alastair, Smith, Craig, Wilkinson, Kate, Stewart, Richard, Chevis, Chrissie, Ekpa, John, Greig, Nurse Sara, Hinch, Nurse Rebecca, Holder, Carole, Makris, Nikolaos, Moran, Nurse Louise, Padilla Harris, Nurse Cheryl, Scarletta, Nurse Diane, Smith, Jeanette, Sara-Beth Sutherland, Nurse, Turner, Joanne, Valentine, Peter, van Manen, Amelia, Walia, Nurse Sonia, White, Nurse Charlotte, Wilson, Georgina, Wren, Nurse Lynn, Wright, Nurse Francesca, Faulds, Matthew, Agius, Claire-Marie, Ahmed, Raheel, Ahmed, Sameer, Alva, Arjun, Bird, Rachael, Buckley, David, Calder, Verity, Clark, Caroline, Craven, Emily, Cullen, Katherine, Davis, John, Diamond-Fox, Sadie, Doherty, Helen, Dutta, Bhaskar, Fortune, Jonathan, Gatehouse, Alexandra, Gibson, Jane, Hay, David, Hillier, Steve, Hindmarch, Paul, James, Michael, Keshvara, Kiran, Kotur, Karuna, Lawley, Peter, Lochanie, Nimali, Macbeth, Lisa, Madhu, Yamuna, Marcangelo, Sam, McShane, Lesley, Morgan, Amy, Mowat, Stephen, Nelson, Joshua, O'Leary, Denis, Partridge, Jennifer, Pearson, Janaki, Poulton, Tom, Prasad, Sneha, Protheroe, Kay, Qureshi, Adnaan, Rangaswamy, Girish, Richardson, Victoria, Scott, Carmen, Smallshaw, Karen, Soliman, Abdelrahman, Soulsby, Graham, Wahed, Anna, Walker, Iain, Welch, Sarah, Wilson, Jessica, Winkley, Elaine, Womack, Jonathan, Mitchell, Joellene, O'Brien, Peter, Callaghan, Debbie, Clarke, Ruth, Foggo, Graeme, Gilmour, Danielle, Hickey, Stephen, Hii, Stephanie, Livingstone, Susan, McAtear, Megan, Meehan, Sharon, Milne, Gemma, Small, James, Williams, Dewi, Jardine, Catherine, White, Graham, Wright, David, Hunter, Katie, Fleming, Gillian, Marc Hastie, P.A.-A., Hunter, Catherine, Lockhart, Jennifer, Reid, Kirsten, Robb, Hilary, Harten, Johann, Crooks, Barbara A., Ratnasabapathy, Urmila, Staber, Manfred, Pettigrew, Tom, Varveris, Daphne, Brett, Michael, Appleton, Richard, Briskoe, Michael, Brown, Graeme, Brown, Stewart, Christie, Fiona, Coady, Guy, Cowan, Richard, Drysdale, Alice, D'Sylva, Stewart, Edgar, Paul, Finnie, Graeme, Gardner, John, Gupta, Shub, Hall, Colin, Hamilton, Jane, Hunter, Laura, Ikram, Umairali, Imrie, Gregor, Kerr, Euan, Kinsella, Michael, Kommer, Maya, Lafferty, Brian, Lochrin, Christopher, Lovejoy, Tom, Loy, Maria, MacLean, Aillison, MacPherson, David, Marshall, Cara, Mawhinney, Ruth, McAteer, Claire, McCaul, Prof James, McCusker, Michael, McDowall, Katherine, McGovern, Christopher, Mckie, Stewart, Morrison, Melanie, Mulla, Suleman, Neale, Elizabeth, Niciu, Cristina, Ong, Su Ying, O'Sullivan, Finbar, Parcell, Sophie, Ramsay, Sarah, Robson, Rebecca, Roy, Nithin, Samuel, Jasmine, Scotland, Gemma, Sharma, Natasha, Slade, Kate, Soosay, Alvin, Soulsby, Charlotte, Steuart, Lois, Stevenson, Sara, Sweeney, Laura, Tan, Kerwei, Taylor, Calum, Th'ng, Francesca, Thompson, Caroline, Wardlow, James, Watson, Martin, Williams, Robin, Woodier, James, Young, Simon, Robinson, David, Howes, Jacqueline, Berwick, Scott, Boyle, Andrew, Brown, Neil, Celnik, Anna, Coleman, Alistair, Elwkhiee, Mohamed, Fernandes, Mario, Hanlon, Katie, MacLean, Sarah, Morgan, Rhian, Edgar, Jonathan, Chapman, Roddy, Razouk, Khaled, Atrah, Ali, Bhat, Sunny, Bramma, Yvonne, Campbell, Euan, Campbell, Rachel, Cormack, Anna, Dalchow, Stephan, Dodd, Ammy, Ferguson, Laura, Ferraioli, Donna, Hynd, Moyra, Janeczko, Adam, Jeffrey, Sally, Kinsey, Tony, Kummur, Yuvaraj, McIntosh, Karen, McKenna, John, Mclaughlin, Maria, Millington, Ryhs, Murphy, Emma, Parker, Kris, Reevell, Tom, Robertson, Fiona, Shankey-Smith, Will, Slorach, Colum, Szelei, Tamas, Warnock, Geoff, Watson, Stuart, Alston, Peter, Geddes, Murray, McLellan, Stuart, Allen, Eireann, Birnie, Karen, Brown, Kirsteen, Critchley, Julia, Cullen, Margaret, Eros, Alex, Forbes, Callum, French, Helen, Hall, David, Hetherington, Jonathan, Kellner, Maximiliane, Kelly, Keith, Khaled, Hiba, Mantle, Damien, McLenachan, John, Midgley, Susan, Nimmo, Susan, Ordys, Bart, Phelan, Hannah, Roddam, Philip, Shaw, Louise, Smith, Carolyn, Steel, Elizabeth, Stuart, Robert, Sturrock, John, Waite, Alasdair, Waterson, Fraser, Watson, Hannah, Wood, Elizabeth, Schraag, Stefan, Boyd, Elizabeth, Jain, Surabhi, Matthews, Elaine, Rappai, Geejo, Barr, Catriona, Stewart, Michael, Christie, Sharon, Smith, Tim, Arrow, Kate, Austin, Pauline, Chapman, Susie, Little, Jonathan, Malein, William, Sadler, Amy, Younger, Rhona, Reavley, Caroline, Allan, Katy, Ashok, Vignesh, Boroojeny, Ayda Borjian, Cutts, John-Paul, Faulds, Fiona, Fernie, Mark, Gadre, Amit, Gately, Tom, Haddon, Richard, Induruwage, Lalani, King, Siobhan, Liddle, Sian, Mallett, Paul, Mehotra, Saurabh, Ali, Inthekab Mohammed, Morris, Rachel, Nunn, David, Ferraro, Rocio Ochoa, Padhi, Pulak, Prusack, Ewa, Quak, Edmund, Singleton, Georgina, So, Kin, Stolady, Daniel, Welch, Drew, Whitear, Michael, Wilkinson, Kathy, Wu, James, Yusaf, Alex, Kakodkar, Prashant, Ghoneim, Hoda Abou, Balliston, Sara, Dudgeon, Lucy, Idris, Muna Elsheikh, Karattuparambil, Juneenath, Nanda, Lohita, Raithatha, Bhavesh, Saad, Mahmood, Spimpolo, Jenny, Titinchi, Linda, Wilson, Julie, Winstone, Ulrika, Martindale, Sarah, Cameron, Ewen, Fenner, Lynn, Hartford-Beynon, Jake, Mooney, Iain, Mundy, Charlotte, Rhidian, Rhys, Scutt, Sophie, Todd, Anna, Graham, Fiona, Ashton, Amy, Cooper, Theresa, Davidson, Katherine, Eapen, Suresh, Crowther, Hannah, Hindmoor, Claire, McSkeane, Anna, Mostafa, Mahamed, Mudimadagu, Gururaj, Rice, Polly, Wilson, Antoinette, Henry, Garry, Hollister, Nigel, Hunt, Jane, Isaac, Amanda, Morris, David, Paredes-Guerra, Antonio, Pass, Katherine, Paul, Martin, Rait, Kiran, Rousseau, Guy, Shacklock, Emma, Skinner, Amanda, Stancombe, Lucia, Thomson, Laura, Nutt, Christopher, Wright, Geoffrey, Holland, Johnny, O'Neill, Orla, Sengottaiyans, Arun, Mitra, Atideb, Garg, Sanjeev, Adams, Jonathan, Aiyedun, Temitope, Ali, Hani, Biuk, Sahar, Bond, Bryany, Cheeseman, Michelle, Clayton, Mark, Cottam, Lisa-Jayne, Dent, Kathy, Evans, Elizabeth, Evans, Sandra, Goodhand, Hannah, Green, Karen, Hatton, Jonathan, Hill, Joanne, Hutchinson, Dorothy, Jacob, Shibu, Joseph, Renjith, MacNally, Laura, Mann, Jason, McTaggart, Virginia, Newton, Maria, Pearson, Sandra, Rayet, Jaspreet, Saunders, Rebecca, Saxena, Sandeep, Venkatesh, Hemamangala, Whotton, Nikita, Ezihe-Ejiofor, Ada, Barot, Hemangini, Bridger, Hayley, Elhallous, Shady, Ghafoor, Rizana, Manhas, Vitul, Patil, Tanmay, Sadavarte, Nitin, Tharmalingam, Bhamini, Pritchard, David, Bage, Jean, Higgin, Sarah, Krishnaier, Asokan, Neilly, Esther, Rayappu, Sean, Siaw, Chye, Songaile, Ilma, Standen, Peter, Suresh, Narayanan, Weston, William, Williams, Lynne, Yuchen, Jiang, Alagar, Ravi, Taylor, Adrian, Matata, Claire, McCrossan, Roopa, Robertson, Andrew, Shekar, Priya, Stoker, Wendy, Turnbull, Elizabeth, Watkinson, Clare, Worthy, Stephen, Yates, Bryan, Ignatov, Dancho, Davies, Matthew, Abdu, Ayman, Banni, Donata, Bowyer, Helen, Brooks, David, Buhmann, Ulf, Christenssen, Victoria, Collins, James, D'Sa, Aaron, Forde, Steven, Groves, Alice, Hosahalli, Jyothi, Hunt, Lauren, Koshy, George, Lee, Robyn, Martin, Susan, McKnight, Angus, Murphy, Piers, Nash, Henry, Nkanang, Bassey, Oracki, Pamela, Pauley, Tara, Pope, Alan, Samanta, Romit, Sgardelis, Panagiotis, Stocks, Tom, Vaitheeswaran, Sivaprakash, Verma, Priya, Vrazhalska, Madlena Ivanova, Weisz, Mike, Moppett, Iain, Arunachalam, Subha, Begum, Zorba, Bhangu, Sonia, Bown, Gemma, Chana, Avninder, Chhaniyara, Puja, Constable, Natalie, Delme, Luff, Fenner, Helen, Griffith, Oliver, Hackett, Stephen, Hewson, David, Inkpin, Kristofor, Jones, Richard, Kirkdale, Richard, Lyons, Ian, Mandal, Arnab, Mehrotra, Prerna, Murphy, Martin, Pearce-Smith, Alison, Priestley, Martin, Pyke, Shirley, Rasoli, Sonia, Sharma, Suneal, Squires, Gemma, Tsim, Peter, Veitch, Jonathan, Bond-Smith, Giles, Kay, Olivia, Siviter, Richard, Allen, John, Baxter, Linden, Beer, Sally, Bernardo, Mariana, Coles, Holly, Cudlip, Jo, Devries, Talitha, Duggleby, Phil, Espinosa, Alexis, Fitzgibbon, Karina, Galente, Joao, Georgiou, Domonique, Ghosh, Soumi, Hingley, Nicholas, Kingan, Ryan, Levett, Chris, Martinez, Jose, Mattin, Alex, Moore, Anna, Morrish, Samuel, Nash, Amy, Patel, Tejuswi, Roe, Cieron, Thwaites, Victoria, Wali, Anuj, Watterson, Dafydd, Charlotte Yates, Anna Wilson, Gimenez, Marc, Boltres, Anita, McClean, Rebecca, Papadopoullos, Sam, Teh, Elena, Webb, Stephen, Brammar, Andrew, Humphreys, Joanne, Alibhai, Moiz, Alston, Daisy, Cohen, Jolyon, Coleman, Laura, Davies, Simon, Dervin, Dionne, Dooley, Rebecca, Drummond, Andrew, Findlay, Douglas, Fleming, Naomi, Hammoud, Yazzim, Hussain, Sanniah, Irwin, Katy, Javed, Asad, Kent, Linda, Lock, Lorraine, McSorland, Denise, Meadows, Alison, Mulligan, Paula, Nichols, Wendy, O'Callaghan, Maria, Ogor, Jonathan, Poole, Joanna, Ryder, Geoffrey, Shakoor, Akmal, Teo, Wei, Minto, Gary, Adshead, Stephen, Anderson, Helen, Carpenter, Adam, Clelland, Stuart, Datar, Priya, Elloway, Esme, Holl, Matt, Hulbert, Aidan, Humphreys, James, Hyams, Ben, McAleer, Sam, Newmarch, Mary, Notman, Holly, Patrick, Abigail, Perham, Anna, Pitman, Catherine, Reed, Fiona, Sampson, Paul, Smith, Hannah, Spinney, Sam, Toms, Nina, Warrener, Tim, Girgis, Michael, Barcraft-Barnes, Helena, Camsooksai, Julie, Colvin, Carolyn, Davies, Jack, Hamilton, Alex, Linton, Fiona, Nussbaum, Greg, Patch, Sarah, Simpson, Diane, Tbaily, Lee, Bain, James, A'Court, Alicja, Barr, Emma, Blethyn, Kate, Craig, Thomas, Cutler, Hugh, Davies, Jenny, Fry, Rebecca, Hawes, Elizabeth, Jenkins, Nicholas, Knight, Martin, Restall, David, Stubbs, Matthew, Sutherland, Angus, Swarbrick, Claire, Wilson, Robin, Winwright, Paul, Hamilton, Kevin, Adams, Anne, Allen, Orlanda, Boampomaa, Marilyn, Boniface, Anna-Marie, Coe, Robert, Daniel, Amelia, Finn, Joanne, Gill, Issac, Griffiths, Huw, Hackney, Joanna, Han, Ruth, Hare, Edward, Rintoul, Edward, Shpuza, Ervin, Smith, Ruth, Staines, Nikki, Suppiah, Puvan, White, Tracey, Pearson, Darcy, Cracknell, Ben, Farrell, Nadine, Hermanowski, Jane, Hodgson, Ruth, Hoskins, Toby, Jones, Rhiannon, Keable, Sam, Rosbergen, Melissa, Giles, Julian, Dawes, Thomas, Green, Ben Eden, Pottinger, Gail, Weller, Debbie, John, John, Burgess, Lisa, Denton, Jean, Done, Alaine, Edwards, Jayne, Garrett, Theresa, Gilla, Rajesh, Griffith-Norris, Samantha, Jones, Teresa, Linklater-Jones, Barbara, Nicholas, Claire, Owen, Sara, Perkins, Charlotte, Rowlands, Tessa, Steen, Julie, Turner, Sarah, Wales, Johanna, Woolley, Carol-Ann, Hormis, Anil, Collier, Dawn, Dixon, Kathryn, Gardner, Michael, Murray, Vicky, Soar, Harry, Walker, Rachel, Yaruk, Shifa, Yarwood, Daniel, Dill-Russell, Patrick, ruthy Arumugam, Bird, Georgina, Bleasby, Nichola, Chater-Lea, Peter, Craig, Emma, Davies, George, Foxton, Julie, Gilfillan, Helen, Jerram, Keelan, Kudsk-Iversen, Søren, Lee, Rebecca, Livesy, John, Mohabir, Amanda, Morris, Katherine, Raffles, Mike, Smith, Annika, Wang, Huiqi, Craig, James, Barratt, Nina, Bates, Andy, Bokor, Norbert, Cranshaw, Julius, Dominguez, Sergio, Fraine, Annette, Green, Richard, Molloy, Katie, Penny, Christina, Pitts, Sally, Purandare, Laura, Rabbi, Taslima, Serrano, Monica, Stoycheva, Tina, Vamplew, Luke, Williams, Steve, Berry, Julian, Adams, Benita, Bean, Sarah, Burt, Karen, Devooght-Johnson, Nicki, Hammonds, Fiona, Nicholls, Tom, Rowe, Michelle, Summers, Jessica, Ward, Olivia, Wroath, Belinda, Young, Gabbie, Matthews, Cathryn, Crosbie, Gearoid, Dunn, Alex, Eddy, Sara, Garcia, Lynda, Garwood, James, Green, Adam, Gupwell, Karin, Jones, Nicola, Marriott, Suzie, Masood, Mohammad, Mazzola, Francesca, McEvoy, Evanna, Ng, Yang, Park, Linda, Pauling, Stephanie, Potter, Alison, Renton, Caroline, Samways, Adam, Sibley, Pauline, Stead, Jenny, Thorpe, Kevin, Turner, Elizabeth, Walter, Michelle, Windsor, Kevin, Jha, Rajeev, Hooker, Nicolas, Kidel, Carlos, Abayalingam, Mayavan, Boulding, Richard, Coakley, Philip, Elahi, Noor, Helder, Filipe, Hilton, James, Joshi, Kunal, Kaur, Rupinder, Male, Victoria, Naji, Saqib, Pinto, Manuel, Rajendran, Yohinee, Save, Manjeet, Smith, Megan, Spence, Emily, Tang, Sophie, Urwin, Thomas, Wittenberg, Marc, Yan, Ruoling, Williams, Colin, Ardeshna, Arjun, Bamford, Peter, Hagyard, Sarah, Johnson, Patrick, McMonagle, Martina, Morris, Hayleigh, Murphy, Thomas, Papadopoulos, Stavros, Simpson, Emma, Smith-Williams, Jonathan, Vyapury, Vin, Juneja, Rohit, Black, Ethel, Eeles, Alex, Elliot, Justine, Jhanji, Shaman, Knoetze, Reynard, McCanny, Jamie, Oswald, Lauren, Roderick, Ellie, Gunning, Paul, Siddaiah, Narendra, Balachandar, Krishna, Bhimarasetty, Chandra, Bird, Laura, Blunt, Conny, Da Silva, Egidio, Darbyshire, Mark, Echaveznaguicni, Irene, Girgis, Youssef, Goodman, Martin, Gowda, Dinkar, Gowni, Rajashekar, Hayes, Melony, Jackson, Natalie, James, Anitha, Jayapal, Rekha, Jones, Claudette, Leung, Enid, Minhas, Simran, Mubarak, Mona, Muniyappa, Sudeshkumar, Nassa, Zehrin, Neal, Tom, Nyangoni, Kudakwashe, Panchakshariah, Suresh, Philpott, Bethany, Pinner, Craig, Pygall, Daniel, Rangaiah, Manamohan, Rao, Anil, Rea, William, Shellard, Richard, Shinner, Guy, Sutherland, Tony, Tharakan, Liza, Thomas, Sue, Travasso, Betty, Venkatesh, Pyda, Wortley, Dionne, Dickinson, Matthew, Benoliel, Sophie, Doyle, Nanci, Marriott, Cheryl, Martin, Sarah, Montague, Laura, Penhaligon, Kate, Saha, Rita, Santhirapala, Ramai, Suntharanathan, Lushani, Wakeford, Nichola, Webb, Carly, Winterbottom, Toby, Jordan, Lesley, Aldridge, Matt, Bolton-Hill, Clare, Cook, Prof Tim, Kangesan, Inthu, Kettley, Laura, Mew, Edward, Penketh, James, Quinn, Eleonore, Scholes, Sam, Uppugonduri, Sreekanth Rayalu, Allen, Lara, Lyndsay Bibb, Jill Brown, Busby, Charlotte, Katherine Cheshire, Davis, Matron Beryl, Denyer, Rebecca, Julie Edwards, Gardiner, Laura, Haque, Shamim, Icke, Julia, Jones, Katherine, Donna McIntosh, Mandy Oakley, Prasad, Linda, Victoria Roberts, Smallwood, Andrew, Tammy Smith, Stelfox, Lucy, Angela Stevens, Angela Willberry, Pratt, Oliver, Chincholkar, Mahindra, Darwin, Leanne, Dearden, Joy, Flowerdew, Adele, Harrison, Louise, Hartley, Robert, Ingham, Andrea, Jones, Ben, Lee, Stephanie, Longdon, Elizabeth, Marsden, Tracy, Meats, Kirsty, Michael, Angiy, Norwood-Green, Drew, O'Loughlin, Victoria, Owen, Holly, Patel, Manju, Perez, Jane, Whiston, Jessica, Wood, Andrea, Williams, Simon, Billingham, Chloe, Clarke, Caroline, Holmwood, Xantha, Knighton, Melba, Sands, Becky, Stevens, Paul, Strong-Sheldrake, Sophia, Taylor, Matthew, Rambhatla, Mrutyunjaya Rao, Brodier, Elizabeth, Choudhry, Ozerah, Choudhry, Usman, Fitzmaurice, Bethany, Hulme, Jonathan, Kannan, Santhana, Mak, Kay Anne, Namih, Miriam, Rajdev, Bharati, Rambhatla, Swetha, Reilley, Stuart, Rice, Rebecca, Sethia, Nalini, Smith, Katy, Wakhle, Rahul, Walmsley, Chris, Wrench, Ian, Agyemang, Michael, Bell, Elizabeth, Bird, Sarah, Briscoe, James, Cruickshanks, Andy, Drinkwater, Jake, Eggleston, Sam, Elms, Henry, Hammon, Laura, Harris, Meredith, Harrison, Christopher, Hirst, Claire, Housley, Kay, Kapoor, Krish, Kibutu, Faith, Kilner, Beverly, King, Emily, Kirk, Emily, Marshall, Esme, Mazzone, Paolo, Middle, Janet, Milner, Leanne, Mitchell, Adam, Morris, Becky, Mudd, Alexandra, Needham, Matthew, Nicholas, James, Penson, Rob, Perfitt, Joel, Pinkerton, Mark, Recto, Mayeth, Rehnstrom, Maria, Riley, Catherine, Ryan, Lorna, Smith, Jennie, Strong, Samantha, Thornley, Helen, Tookey, Bethany, West, Daniel, Whitaker, John, Willcock, Sarah, Willoughby, Shay, Wright, Jane, Jones, Paul, Abbott, Riquella, Bacon, Lisa, Godden, Christopher, Howe, David, Loughlin, Angela, Moore, Helen, Passey, Samuel, Rodgers, Rebekah, Foley, Paul, Hagan, Samantha, Marcus, Simon, Gardner, Irene, Haslam, Zena, Morrison, Moira, Obeysekera, Chai, Porter, Kim, Terrett, Helen, Henning, Jeremy, Baillie, Kirsty, Buchanan, Ella, Cain, Martyn, Colling, Kerry, Duarte, Raquel, Gibb, Chris, Hynd, Ryan, Irvine, Victoria, Lyons, Rob, Middleton, Karoline, Razaque, Usman, Sheikh, Faisal, Tabiner, Tariq, Frey, Christian, Brown, Carly, Clifford, Gayle, McKee, Madeleine, Stidolph, Beverley, White, Emert, Campbell, Bridget, Mason, Sophie, Parsons, Penny, Santana-Vaz, Natasha, Stagg, Camilla, Shah, Nirav, Barnes, Veronica, Bedoes, Penny, Clarke, Jonathan, Crichton, Robert, Das, Madhurima, Davies, Paul, Farrah, Helen, Hegarty, Aoife, Howlett, Luisa, Kleine-Brueggeney, Maren, Ma, Samson, Marsh, Veronica, McAndrew, Katherine, Mellinghoff, Johannes, Oscier, Christopher, Ryan, Christine, Smee, Elizabeth, Thurairasa, Dushanthi, Goel, Vandana, Adeney, Christopher, Behl, Sanjay, Chadwick, Karen, Coleman, Thomas, Davies, Claire, Dealing, Sharon, Elwood, Jamie, Fadden, Emma, Gillies, Stella, Kennedy, Tom, Miller, Thomas, Morton, Simon, Reilly, Rebecca, Smyth, Sue, Syratt, Thomas, Welfare, Emma, Thomas, Elizabeth, Awolesi, Jennifer, Bennett, Hannah, Bradshaw, Elizabeth, Crabtree, David, Duraman, Lauren, Hughes, Kerry, Kirk, Sarah, Leonard, Dee, Stoeter, Rachel, Parrington, Simon, Andorka, Matyas, Ang, Kingsin, Bailey, Linda, Brooks, Stephanie, Chiu, Oon, Collins, Sally, Jack, James, Knight, Harry, Lynn-Smith, Anastasia, Mackenzie, Matt, Maher, Sarah, Nimako, Louise, Sangaralingham, Siva, Sanusi, Seliat, Weller, Samantha, Willard, Elizabeth, Kulkarni, Anand, Carroll, Peter, Clark, Martyn, Coulding, Martina, Denman, Elizabeth, El Habishi, Mohyman, Haywood, Patrick, McConniffe, Jane, McCormick, Jacqueline, Melachuri, Krishnakar, Philip, Evelyn, Ridgway, Stephanie, Savill, Heather, Sharif, Kamal, Vere, Joanne, Harris, Stephen, Coombs, Alex, Darch, Flora, Doble, Patricia, Foot, Jayne, Gillett, Chris, Judd, Thomas, Moss, Alison, Pawley, Corinne, Tait, Moira, Whitcher, Alison, Wood, Natalie, Montgomery, Jane, De Selincourt, Gabrielle, Fitzell, Pauline, Flower, Katie, Horan, Kathleen, Hulance, Bianca, Mercer, Pauline, Shaw, Sarah, Webber, Robin, Kakkar, Manish, Joachim, Suganthi, Aggarwal, Seetal, Ali, Amr, Ang, Boon, Bhardwa, Vishnu, Deamer, Wendy, Filby, Lorna, Fletcher, Jo, Fombon, Felix, Gawley, Shannon, Gosavi, Chandrakant, Hindle, Julia, Lawrence, Tara, Maher, Robert, Moore, Samantha, Netherton, Kimberley, Orasanu, Teodora, Poimenidi, Evangelia, Potter, Louise, Ranasinghe, Niyesa, Ribeiro, Lester, Ruth, Thoy, Butler, Susie, Sutton, Tim, Thomas, Issy, Veluvolu, Divya, Walker, Thomas, Wariyapola, Charindri, Zaheer, Lail, Luoma, Valpuri, Ferguson, Catriona, Stewart, Adrienne, Bapat, Smita, Bose, Gahan, Bugo, John, Campbell, Marta, Cervi, Elizabeth, Ciechanowicz, Sarah, Coathup, Rachel, El-Wahab, Niveen, Frith, Claire, Gill, Preea, Gray, Martin, Luoma, Astri, Mehta, Sachin, Murali, Mayur, Mussad, Asya, Parker, Laura, Patch, Josh, Perella, Paolo, Robson, Emily, Setty, Thunga, Vieira, Filipe, Wall, Josh, Witby, Jon, Zghaibe, Wael, Zhang, Sheldon, Merron, Stephen, Abano, Nenette, Barnett, Loretta, Barry, Adrian, Birks, Pamela, Brade, Judith, Butler, Adrian, Carpio, Racquel, Colclough, Viv, Eaton, Katrina, Edwards, Carol, Emery, Lisa, Finney, Kay, Gallagher, Susan, Ghatge, Satyajeet, Grocott, Jeanette, Hall, Amanda, Hardwick, Alison, Harrison, Anne, Hendy, Susan, Hiden, Joanne, James, Alex, Jeganath, Vijay, Kumar, Rahul, Lord, Stephen, Lovatt, Rachel, Lyjko, Susan, Maguire, Holly, Marsden, Mia, Mehta, Venu, Mishra, Rajeev, Mittal, Rohit, Moores, Andrew, Nalwaya, Pramod, Omeara, Matthew, Orosz, Sandor, Patel, Nehal, Pattison, Nicola, Ponce, Ida, Puttapa, Ashok, Rajamanickam, Tamilselvan, Rao, Nagaraj, Remegoso, Alda, Rhodes, Rochelle, Rooney, Angela, Sadler, Emma, Singh, Permendra, Soon, Wai, Tomlins, Simon, Umbarje, Kanchan, Vallabhaneni, Murali, Varquez, Resti, Wain, Jill, White, Sorana, Willetts, Elizabeth, Williams, Benedict, Wood, Andrew, Washington, Stephen, Anipindi, Sujata, Aston, Jennifer, Bradley-Potts, Joanne, Butler, Ian, Cunningham, Jennifer, Duncan, Alastair, Garrard, Hywel, Haslam, Daniel, Kirk, Danielle, McCormick, Richard, McEvoy, Michael, Mistry, Sara, Ormandy, Danielle, Sharp, Tracy, Song, Andrew, Williamson, Georgina, Young, Francis, Tasker, Laura, Bailey, Elizabeth, Baker, Roisin, Bamford, Amy, Bergin, Colin, Blackburn, Julia, Bodo, Kinga, Carrera, Ronald, Cooper, Lauren, Despy, Liesl, Ellis, Karen, Foster, Morgan, Garner, Sharon, Harkett, Lyndon, Harkett, Samantha, Ip, Peter, Lay, Frances, Liu, Hon Sum, Mee, Laura, Nazir, Samir, Osbourne-Wylde, Jacob, Patel, Krupali, Pope, Martin, Reeves, Emma, Sahni, Melanie, Small, Charlotte, Spooner, Brendon, Spruce, Elaine, Whitehouse, Arlo, Wharton, Nicholas, Alexander, Rachel, Ashford, Amy, Aspinall, Rebecca, Bateman, Richard, Bell, Matthew, Bennett-Britton, Jennifer, Bewley, Jeremy, Blanshard, Hannah, Bourdeaux, Christopher, Brook, Peter, Cain, Helen, Cameron, Claire, Cassells, Naomi, Chauhan, Nilesh, Clarke, Adrian, Cockroft, Melanie, Cohen, Alan, Collins, Joanna, Cominos, Timothy, Craven, Rachael, Davies, Ian, Dolling, Sarah, Dowse, Claire, Driver, Kate, Duffen, Adam, Dunn, Sarah-Jane, Earnshaw, Charlotte, Forrest, Frances, Freshwater-Turner, Dan, Gardner, Issie, Gibbins, Matthew, Gibbison, Ben, Gleeson, Suzanne, Gould, Timothy, Govier, Matthew, Gupta, Benjamin, Hadfield, John, Harvey, Nicola, Henderson, Sophia, Herbert, Lara, Hillier, James, Hood, Elizabeth, Howes, Ben, Howes, Helen, Hughes, Sian, Jackson, Kathryn, Jacobs, Toby, Jenkins, Emma, Jenkins, Ian, Johnstone, Alistair, Jones, Lydia, Jones, Rebecca, Joshi, Natasha, Kamalanathan, Kajan, Kellie, Neil, Kidd, Lawrence, Kinsella, Mike (Stephen), Knight, Thomas, Leslie, Rebecca, Linter, Stephen, Lovell, Tim, Martin, Matthew, McHugh, Ursula, McIndoe, Andrew, McKendry, Rachel, Middleditch, Alexander, Miles, Edward, Milne, Lesley, Molyneux, Mat, Muchatuta, Neil, Murphy, Ruth, O'Higgins, Fran, Oglesby, Kieran, Pachucki, Marcin, Paoloni, Claudia, Patel, Nishita, Patton, Catherine (Katie), Paulich, Skylar, Pearson, Annabel, Pickering, Anthony, Platt, Martin, Pope, Charlie, Pryn, Steve, Ranjan, Amit, Rasburn, Neil, Ray, Andrew, Rivers, Jonathan, Rooney, Kieron, Ryder, Ian, Sanders, Sarah, Sasi-Kumar, Kavita, Scott, Liam, Scrutton, Mark, Searles, Chloe, Self, James, Shah, Sanjoy, Sheils, Mark, Shipway, Toby, Short, Heather, Simmonds, Lauren, Smith, Daniela, Soodan, Anjali, Steeds, Charlotte, Sweet, Katie, Syme, Phoebe, Thomas, Matthew J., Tomkins, Sally, Underwood, Susan, Wagstaff, Adrian, Watson, Paul, Webster, Denise, Welham, Katie, Whaley, Anne, Williams, Helen, Wilson, Hannah, Winton, Anoushka, Woodward, Thomas, Worthington, Jeanie, Younie, Stuart, Bradbury, Carol, Auldin, Mohammad, Bosworth, Kate, Choksey, Falguni, Dudkowsky, Bernice, Elton, John, Evans, Gail, Grove, Charlotte, Ingram, Clare, Kelly, Andrew, Lax, Peter, Lynes, Elena, Madden, George, Mistry, Vinesh, Molitor, Timothy, Morgan, Catherine, Morris, Natalie, Pallister, Emily, Patel, Pooja, Ragothaman, Vijay, Ramm, Katie, Robinson, Ben, Sharma, Meghna, Shuttleworth, Daniel, Vaidyanath, Chandrashekhar, Warren, Jen, Wong, Rachel, Lau, Gary, Conway, Hannah, Majeed, Adeel, Parmar, Jaina, Rana, Meenal, Yusuff, Hakeem, Rimmer, Corinne, Abdelrhamen, Wael, Allison, Kathryn, Burns, Karen, Cahill, Nichola, Clark, Jon, Donaldson, Hannah, Heseltine, Nick, Mackenzie, Nicola, McArthur, Carol, Moreland, Neil, Shohelly, Sharmin, Thatcher, Hilary, Tran, Steven, Walker, Catriona, Al-Rawi, Samar, Wakatsuki, Mai, Aarvold, Alice, Addy, Melissa, Ashfield, Georgina, Beauchamp, Nigel, Belcher, Alex, Bennett, Tom, Burgess, Victoria, Burton, Andy, Campbell, Matthew, Cruikshank, Ross, Cumpstey, Andy, Davies, Rhys, Ford, Chris, Ford, Renee, Hawkins, Lesley, Hendra, Tim, Huttley, Thomas, Jolly, Erica, Kalcheva, Nevena, Kennedy, Charlie, Lees, Jessica, Lowe, Richard, Martindale, Tim, McCormick, Sarah, McPhee, Hannah, Millinchamp, Fran, Muddanyake, Rahul, Osorio, Eduardo, Patel, Kiran, Pestell, Samuel, Phillips, Steve, Plumb, Jamie, Pratt, Thomas, Quartermain, Bert, Reeves, Rebecca, Robin, Sophie, Scully, Thecla, Sehgal, Anamika, Seifalan, Said, Shuttleworth, Suzanne, Siddique, Omar, Sleap, Esme, Smith, Victoria, Snooks, Richard, Solanki, Virginia, Timmons, Christina, Trimble, Alice, Tunney, Doug, Walker, Kat, Wee, Naomi, Wigley, James, Wilkins, Huw, Wong, Hanna, Wood, Laura, Yogya, Dinithi, Young, Ruth, Shanbhag, Sumant, Ameer, Farrukh, Finnity, Jonathan, Haddock, James, Hunt, Alex, Kuravi, Aditya, Lenehen, Fionnuala, McOwat, Lindsay, Naqvi, Asad, Richardson, Lisa, Siddons, Victoria, Charters, Seema, Jumani, Deepa, Bradley, Peter, Bubb, Laura, Chan, Rebekah, Connell, Lynne, Crone, Rachel, Davis, Hannah, Defeyter, Pascal, Evans, Alison, Howard, Ramdas, Prady, Helena, Rogers, Natalie, Roughley, Lindsay, Whittle, Helen, Zeinali, Daniel, Cherian, Vinanti, Latif, Muhammad Usman, Bajwa, Maqsood, Guy, Jonny, Guz, Krzysztos, Iftikhar, Nauman, Iwanicka, Beata, Khan, Mujeeb, Love, Anna-Marie, Montgomery, Celia, Mulvany, Stephen, O'Kane, Emma, O'Kane, Sinead, Siddiqui, Mansoor, Small, Cathal, Subhani, Shaik, Dana, Emily, Kennedy, Richard, Amey, Isobel, Ashton, Hilary, Baird, Yolanda, Bushell, Caroline, Chadbourn, Indra, Cohen, Merle, Finlay, Emma, Gilbert, Jeanette, Helm, David, Lewis, Carla, Macallan, Jenny, Margalef, Jordi, Martins, Nic, Metiu, Gabi, Moore, Sally, Rose, Hannah, Standley, Tom, Page, Valerie, Bakonyi, Tomas, Ben-Nathan, Simon, Claridge, Melanie, Evans, Jackie, Gardiner, Harriet, Kantsedikas, Ilya, Lachana, Ann, Makker, Ratna, Markwell, Karen, Merrill, Colin, Mukerjee, Prasun, O'Donohoe, Lynn, Oglesby, Fiona, Osbourne, Laura, Parker, Beena, Passaro, Emelia, Russell, Katherine, Shah, Sneh, Sundayi, Saul, Walker, Elaine, Zhao, Xiao, Hosdurga, Guru, Cotterill, Donna, Crowther, Nicola, Dymond, Harvey, Ratcliffe-Law, Thomas, Saunders, Glenn, Saunders, Thomas, Gopal, Vijayakumar, Ahmed, Sajjad, Ali, Abdalla, Crawford, Sarah, De'Ath, Clare, Humphreys, Sally, Swanevelder, Carin, Yap, Yeng, Silk, Jane, Adeniba, Rashidat, Armstrong, Richard, Egole, Osi, Fan, Karen, Gilbert, Kayleigh, Gould, Laura, Hickman, John, Long, Fei, Pahary, Sheik, Reichman, Michelle, Simpson, Kathryn, Singaravelu, Suresh, Ahmed, Dabeeruddeen, Brailsford, Fiona, Bridge, Laura, Collis, Lauren, Jacob, Reni, Jones, Cathy, Kirrage, Amanda, Lowe, Jessica, Mullen, Joanne, Prenter, Andrew, Sarao, Sarbpreet, Sharpley, David, Wankhade, Kavita, Persad, Cindy, Burtenshaw, Andrew, Blyth, Kate, Corcoran, Felicity, Davis, Caroline, Dolan, Rachel, Hussain, Nageena, Pearson, Emma, Pierson, Anna, Poyntz, Victoria, Thrush, Jessica, Wollaston, Alex, Wollaston, Julie, Clements, Paul, Biswas, Arindam, Clayton, Sarah, Clayton, Thomas, Cochrane, Naomi, Duell, Kirsty, Evans, James, Gaskell, Mark, Heaton, Dianne, Heaton, Linzi, Hill, Claire, Killen, Ruth, Latham, Sandra, McIntosh, Gemma, Moore, Chris, Parkinson, Val, Pemberton, Nicola, Robinson, Matthew, Sawyer, Alastair, Sykes, Isabelle, Taylor, Tracey, Tierney, Caroline, van de Snepscheut-Jones, Katja, Wade, Emily, Wahid, Mohammed, Wang, Henry, Williams, Claire, Wu, Dominic, Yadagiri, Manjula, Zabauski, Dmitry, Troth, Laura, Andrews, Eleanor, Bains, Ranjit, Beard, Laura, Birch, Janine, Britton, Rachael, Salmon, Mike, Vassell, Elizabeth, Kubisz-Pudelko, Agnieszka, Allen, Jamie, Allison, Joanna, Baird, Andrew, Gregory, Rob, Luckhurst, Hannah, Mairs, Rebecca, Marshall, Ben, Pippard, Lucy, Pitt-Kerby, Tressy, Savva, Andrew, Walkden, Graham, Weegenaar, Celly, Chandler, Ben, Kanakaraj, Muthuraj, Chamberlain, Andy, Dyer, Simon, Elliott, Kerry, Forshaw, Greg, Furness, Rosie, Gibson, Andy, Howe, Laura, Kent, Sarah, Rodgers, Alicia, Straughan, Ben, Temlett, Emma, Whitwell, John, Wong, D.J.N., Harris, S.K., and Moonesinghe, S.R.
- Published
- 2018
- Full Text
- View/download PDF
4. Safety and immunogenicity of the inactivated whole-virus adjuvanted COVID-19 vaccine VLA2001
- Author
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Lazarus, Rajeka, Taucher, Christian, Brown, Claire, Corbic, Irena, Danon, Leon, Dubischar, Katrin, Duncan, Christopher J A, Eder-Lingelbach, Susanne, Faust, Saul N, Green, Christopher, Gokani, Karishma, Hochreiter, Romana, Wright, Johanna Kellett, Kwon, Dowan, Middleditch, Alexander, Munro, Alasdair P S, Naker, Kush, Penciu, Florentina, Price, David, Querton, Benedicte, Riaz, Tawassal, Ross-Russell, Amy, Sanchez-Gonzalez, Amada, Wardle, Hayley, Warren, Sarah, and Finn, Adam
- Abstract
Objectives: We aimed to evaluate the safety and optimal dose of a novel inactivated whole-virus adjuvanted vaccine against SARS-CoV-2: VLA2001. Methods: We conducted an open-label, dose-escalation study followed by a double-blind randomized trial using low, medium and high doses of VLA2001 (1:1:1). The primary safety outcome was the frequency and severity of solicited local and systemic reactions within 7 days after vaccination. The primary immunogenicity outcome was the geometric mean titre (GMT) of neutralizing antibodies against SARS-CoV-2 two weeks after the second vaccination. The study is registered as NCT04671017. Results: Between December 16, 2020, and June 3, 2021, 153 healthy adults aged 18–55 years were recruited in the UK. Overall, 81.7% of the participants reported a solicited AE, with injection site tenderness (58.2%) and headache (46.4%) being the most frequent. Only 2 participants reported a severe solicited event. Up to day 106, 131 (85.6%) participants had reported any AE. All observed incidents were transient and non-life threatening in nature. Immunogenicity measured at 2 weeks after completion of the two-dose priming schedule, showed significantly higher GMTs of SARS-CoV-2 neutralizing antibody titres in the highest dose group (GMT 545.6; 95% CI: 428.1, 695.4) which were similar to a panel of convalescent sera (GMT 526.9; 95% CI: 336.5, 825.1). Seroconversion rates of neutralizing antibodies were also significantly higher in the high-dose group (>90%) compared to the other dose groups. In the high dose group, antigen-specific IFN-γ expressing T-cells reactive against the S, M and N proteins were observed in 76, 36 and 49%, respectively. Conclusions: VLA2001 was well tolerated in all tested dose groups, and no safety signal of concern was identified. The highest dose group showed statistically significantly stronger immunogenicity with similar tolerability and safety, and was selected for phase 3 clinical development.
- Published
- 2022
5. Safety and immunogenicity of the inactivated whole-virus adjuvanted vaccine VLA2001: A randomized, dose escalation, double-blind phase 1/2 clinical trial in healthy adults.
- Author
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Lazarus, Rajeka, Taucher, Christian, Brown, Claire, Čorbic Ramljak, Irena, Danon, Leon, Dubischar, Katrin, Duncan, Christopher J.A., Eder-Lingelbach, Susanne, Faust, Saul N., Green, Christopher, Gokani, Karishma, Hochreiter, Romana, Wright, Johanna Kellett, Kwon, Dowan, Middleditch, Alexander, Munro, Alasdair P.S., Naker, Kush, Penciu, Florentina, Price, David, and Querton, Benedicte
- Abstract
Objectives: We aimed to evaluate the safety and optimal dose of a novel inactivated whole-virus adjuvanted vaccine against SARS-CoV-2: VLA2001.Methods: We conducted an open-label, dose-escalation study followed by a double-blind randomized trial using low, medium and high doses of VLA2001 (1:1:1). The primary safety outcome was the frequency and severity of solicited local and systemic reactions within 7 days after vaccination. The primary immunogenicity outcome was the geometric mean titre (GMT) of neutralizing antibodies against SARS-CoV-2 two weeks after the second vaccination. The study is registered as NCT04671017.Results: Between December 16, 2020, and June 3, 2021, 153 healthy adults aged 18-55 years were recruited in the UK. Overall, 81.7% of the participants reported a solicited AE, with injection site tenderness (58.2%) and headache (46.4%) being the most frequent. Only 2 participants reported a severe solicited event. Up to day 106, 131 (85.6%) participants had reported any AE. All observed incidents were transient and non-life threatening in nature. Immunogenicity measured at 2 weeks after completion of the two-dose priming schedule, showed significantly higher GMTs of SARS-CoV-2 neutralizing antibody titres in the highest dose group (GMT 545.6; 95% CI: 428.1, 695.4) which were similar to a panel of convalescent sera (GMT 526.9; 95% CI: 336.47, 825.06). Seroconversion rates of neutralizing antibodies were also significantly higher in the high-dose group (>90%) compared to the other dose groups. In the high dose group, antigen-specific interferon-γ expressing T-cells reactive against the S, M and N proteins were observed in 76, 36 and 49%, respectively.Conclusions: VLA2001 was well tolerated in all tested dose groups, and no safety signal of concern was identified. The highest dose group showed statistically significantly stronger immunogenicity with similar tolerability and safety, and was selected for phase 3 clinical development. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
6. Preoperative N-terminal pro-B-type natriuretic peptide and myocardial injury after stopping or continuing renin–angiotensin system inhibitors in noncardiac surgery: a prespecified analysis of a phase 2 randomised controlled multicentre trial.
- Author
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Gutierrez del Arroyo, Ana, Patel, Akshaykumar, Abbott, Tom E.F., Begum, Salma, Dias, Priyanthi, Somanath, Sameer, Middleditch, Alexander, Cleland, Stuart, Brealey, David, Pearse, Rupert M., and Ackland, Gareth L.
- Subjects
- *
BRAIN natriuretic factor , *MYOCARDIAL injury , *RENIN-angiotensin system , *MYOCARDIAL reperfusion , *VENTRICULAR ejection fraction , *HEART metabolism disorders - Abstract
Patients with elevated preoperative plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP >100 pg ml−1) experience more complications after noncardiac surgery. Individuals prescribed renin–angiotensin system (RAS) inhibitors for cardiometabolic disease are at particular risk of perioperative myocardial injury and complications. We hypothesised that stopping RAS inhibitors before surgery increases the risk of perioperative myocardial injury, depending on preoperative risk stratified by plasma NT-proBNP concentrations. In a preplanned analysis of a phase 2a trial in six UK centres, patients ≥60 yr old undergoing elective noncardiac surgery were randomly assigned either to stop or continue RAS inhibitors before surgery. The pharmacokinetic profile of individual RAS inhibitors determined for how long they were stopped before surgery. The primary outcome, masked to investigators, clinicians, and patients, was myocardial injury (plasma high-sensitivity troponin-T ≥15 ng L−1 or a ≥5 ng L−1 increase, when preoperative high-sensitivity troponin-T ≥15 ng L−1) within 48 h after surgery. The co-exposures of interest were preoperative plasma NT-proBNP (< or >100 pg ml −1) and stopping or continuing RAS inhibitors. Of 241 participants, 101 (41.9%; mean age 71 [7] yr; 48% females) had preoperative NT-proBNP >100 pg ml −1 (median 339 [160–833] pg ml−1), of whom 9/101 (8.9%) had a formal diagnosis of cardiac failure. Myocardial injury occurred in 63/101 (62.4%) subjects with NT-proBNP >100 pg ml−1, compared with 45/140 (32.1%) subjects with NT-proBNP <100 pg ml −1 {odds ratio (OR) 3.50 (95% confidence interval [CI] 2.05–5.99); P <0.0001}. For subjects with preoperative NT-proBNP <100 pg ml−1, 30/75 (40%) who stopped RAS inhibitors had myocardial injury, compared with 15/65 (23.1%) who continued RAS inhibitors (OR for stopping 2.22 [95% CI 1.06–4.65]; P =0.03). For preoperative NT-proBNP >100 pg ml−1, myocardial injury rates were similar regardless of stopping (62.2%) or continuing (62.5%) RAS inhibitors (OR for stopping 0.98 [95% CI 0.44–2.22]). Stopping renin-angiotensin system inhibitors in lower-risk patients (preoperative NT-proBNP <100 pg ml −1) increased the likelihood of myocardial injury before noncardiac surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
7. Safety and immunogenicity of the inactivated whole-virus adjuvanted COVID-19 vaccine VLA2001: A randomized, dose escalation, double-blind phase 1/2 clinical trial in healthy adults.
- Author
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Lazarus R, Taucher C, Brown C, Čorbic Ramljak I, Danon L, Dubischar K, Duncan CJA, Eder-Lingelbach S, Faust SN, Green C, Gokani K, Hochreiter R, Wright JK, Kwon D, Middleditch A, Munro APS, Naker K, Penciu F, Price D, Querton B, Riaz T, Ross-Russell A, Sanchez-Gonzalez A, Wardle H, Warren S, and Finn A
- Subjects
- Adult, Antibodies, Neutralizing, Antibodies, Viral, Double-Blind Method, Humans, Immunization, Passive, Immunogenicity, Vaccine, SARS-CoV-2, COVID-19 Serotherapy, COVID-19 prevention & control, COVID-19 therapy, COVID-19 Vaccines adverse effects
- Abstract
Objectives: We aimed to evaluate the safety and optimal dose of a novel inactivated whole-virus adjuvanted vaccine against SARS-CoV-2: VLA2001., Methods: We conducted an open-label, dose-escalation study followed by a double-blind randomized trial using low, medium and high doses of VLA2001 (1:1:1). The primary safety outcome was the frequency and severity of solicited local and systemic reactions within 7 days after vaccination. The primary immunogenicity outcome was the geometric mean titre (GMT) of neutralizing antibodies against SARS-CoV-2 two weeks after the second vaccination. The study is registered as NCT04671017., Results: Between December 16, 2020, and June 3, 2021, 153 healthy adults aged 18-55 years were recruited in the UK. Overall, 81.7% of the participants reported a solicited AE, with injection site tenderness (58.2%) and headache (46.4%) being the most frequent. Only 2 participants reported a severe solicited event. Up to day 106, 131 (85.6%) participants had reported any AE. All observed incidents were transient and non-life threatening in nature. Immunogenicity measured at 2 weeks after completion of the two-dose priming schedule, showed significantly higher GMTs of SARS-CoV-2 neutralizing antibody titres in the highest dose group (GMT 545.6; 95% CI: 428.1, 695.4) which were similar to a panel of convalescent sera (GMT 526.9; 95% CI: 336.5, 825.1). Seroconversion rates of neutralizing antibodies were also significantly higher in the high-dose group (>90%) compared to the other dose groups. In the high dose group, antigen-specific IFN-γ expressing T-cells reactive against the S, M and N proteins were observed in 76, 36 and 49%, respectively., Conclusions: VLA2001 was well tolerated in all tested dose groups, and no safety signal of concern was identified. The highest dose group showed statistically significantly stronger immunogenicity with similar tolerability and safety, and was selected for phase 3 clinical development., Competing Interests: Declaration of Competing Interest AF is a member of the Joint Committee on Vaccination and immunization and chair of the WHO European Technical Advisory Group of Experts on immunization. He is an investigator or provides consultative advice on clinical trials and studies of COVID-19 vaccines produced by AstraZeneca, Janssen, Valneva, Pfizer, and Sanofi, and of other vaccines from these and other manufacturers, including GlaxoSmithKline, VPI Pharmaceuticals, Takeda, and Bionet Asia. He receives no personal remuneration or benefits for any of this work. CTA, KD, SEL, RH, IC, BQ, and JCJ are employees of Valneva Austria GmbH., (Copyright © 2022. Published by Elsevier Ltd.)
- Published
- 2022
- Full Text
- View/download PDF
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