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Your search keyword '"Michele Caterino"' showing total 2 results
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2 results on '"Michele Caterino"'

1. Case report of unusual synchronous anal and rectal squamous cell carcinoma: clinical and therapeutic lesson

Author

Davide Ciardiello, Sara Del Tufo, Paola Parente, Antonietta Gerarda Gravina, Francesco Selvaggi, Iacopo Panarese, Renato Franco, Michele Caterino, Giulia Martini, Fortunato Ciardiello, Roberto Grassi, Salvatore Cappabianca, Alfonso Reginelli, and Erika Martinelli

Subjects
SCC, rectal cancer, anal cancer, HPV, chemo-radiotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Synchronous tumors of the rectum and anus are sporadic. Most cases in the literature are rectal adenocarcinomas with concomitant anal squamous cell carcinoma. To date, only two cases of concomitant squamous cell carcinomas of the rectum and anus are reported, and both were treated with up-front surgery and received abdominoperineal resection with colostomy. Here, we report the first case in the literature of a patient with synchronous HPV-positive squamous cell carcinoma of the rectum and anus treated with definitive chemoradiotherapy with curative intent. The clinical-radiological evaluation demonstrated complete tumor regression. After 2 years of follow-up, no evidence of recurrence was observed.

Published
2023
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2. Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma

Author

Marco Salvatore, Manuel Conson, Gabriella Della Torre, Raffaele Solla, Laura Cella, Roberto Pacelli, Luigi Camera, Marco Picardi, Michele Caterino, Raffaele Liuzzi, A. Farella, Nicola De Rosa, Cella, L, Liuzzi, R, Conson, M, Torre, G, Caterino, M, De Rosa, N, Picardi, Marco, Camera, L, Solla, R, Farella, A, Salvatore, M, and Pacelli, Roberto

Subjects
Adult, Male, Adolescent, medicine.medical_treatment, Heart Valve Diseases, Asymptomatic, Electrocardiography, Risk Factors, Median follow-up, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, Retrospective Studies, business.industry, Mediastinum, Radiotherapy Dosage, Hematology, Odds ratio, Middle Aged, Hodgkin's lymphoma, medicine.disease, Hodgkin Disease, Lymphoma, Radiation therapy, Stenosis, Logistic Models, medicine.anatomical_structure, ROC Curve, Oncology, Ventricle, Female, medicine.symptom, business, Nuclear medicine
Abstract

Purpose To identify dose–heart-volume constraints that correlate with the risk of developing asymptomatic valvular defects (VD) in Hodgkin's lymphoma (HL) patients treated with three-dimensional radiotherapy (RT). Patients and methods Fifty-six patients undergoing cytotoxic chemotherapy (CHT) and involved-field radiation treatment for HL were retrospectively analyzed. Electro-echocardiography was performed before CHT, after CHT, and after RT. For the entire heart, for right and left ventricle (RV, LV), right and left atrium (RA, LA) percentage of volume exceeding 5–30Gy in increment of 5Gy ( V x ), and dosimetric parameters were calculated using 1.6Gy fraction as reference. To evaluate clinical and dosimetric factors possibly associated with VD, univariate and multivariate logistic regression analyses were performed. Results At a median follow up of 70.5months, 32.1% of patients developed VD (regurgitation and/or stenosis): 25.0% developed mitral, 5.4% developed aortic, and 14.3% tricuspid VD. In particular the percentage of LA exceeding 25Gy (LA- V 25 ) and the percentage of LV exceeding 30Gy (LV- V 30 ) correlated with mitral and aortic VD with an odds ratio (OR) of 5.7 (LA- V 25 >63.0% vs. LA- V 25 ⩽63.0%) and OR of 4.4 (LV- V 30 >25% vs. LV- V 30 ⩽25%), respectively. RV- V 30 correlated with tricuspid VD (OR=7.2, RV- V 30 >65% vs. RV- V 30 ⩽65%). Conclusion LA- V 25 , LV- and RV- V 30 prove to be predictors of asymptomatic alteration of valve functionality.

Published
2011
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