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3. Outcome after allogeneic stem cell transplantation with haploidentical versus HLA-matched donors in patients with higher-risk MDS

Author

Michel, Claire, Robin, Marie, Morisset, Stephane, Blaise, Didier, Maertens, Johan, Chevalier, Patrice, Castilla-Llorente, Cristina, Forcade, Edouard, Ceballos, Patrice, Yakoug-Agha, Ibrahim, Poire, Xavier, Carre, Martin, Bay, Jacques-Olivier, Beguin, Yves, Loschi, Michael, Huynh, Anne, Guillerm, Gaëlle, François, Sylvie, Mear, Jean-Baptiste, Duléry, Rémy, Suarez, Felipe, Bilger, Karin, Cornillon, Jérôme, Chalandon, Yves, Maillard, Natacha, Labussière-Wallet, Hélène, Charbonnier, Amandine, Turlure, Pascal, Berceanu, Ana, Chantepie, Sylvain, Maury, Sébastien, Bazarbachi, Ali, Menard, Anne-Lise, Nguyen-Quoc, Stephanie, Rubio, Marie-Thérèse, and D’Aveni, Maud

Published
2023
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5. Thermalization of light waves in multimode optical fibers: Negative temperatures equilibrium states and the role of disorder - INVITED

Author

Baudin Kilian, Garnier Josselin, Berti Nicolas, Fusaro Adrien, Zanaglia Lucas, Michel Claire, Doya Valérie, Krupa Katarzyna, Millot Guy, and Picozzi Antonio

Subjects
Physics, QC1-999
Abstract

Nonlinear random waves exhibit a phenomenon of irreversible thermalization, in analogy with the thermalization of a classical gas system. This irreversible process of thermalization to the Rayleigh-Jeans equilibrium distribution has been recently observed experimentally in multimode optical fibers. Here we discuss a recent progress along two different directions. Firstly, we report the observation of thermalization to negative temperature equilibrium states, in which high-order fiber modes are more populated than low-order modes. Secondly, we analyze the impact of disorder inherent to light propagation in multimode fibers. We identify an unexpected regime in which strong random coupling among non-degenerate modes leads to a nonequilibrium process of Rayleigh-Jeans thermalization.

Published
2023
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11. ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

Author

Murakami, Tetsuro, Qamar, Seema, Lin, Julie Qiaojin, Schierle, Gabriele S. Kaminski, Rees, Eric, Miyashita, Akinori, Costa, Ana R., Dodd, Roger B., Chan, Fiona T.S., Michel, Claire H., Kronenberg-Versteeg, Deborah, Li, Yi, Yang, Seung-Pil, Wakutani, Yosuke, Meadows, William, Ferry, Rodylyn Rose, Dong, Liang, Tartaglia, Gian Gaetano, Favrin, Giorgio, Lin, Wen-Lang, Dickson, Dennis W., Zhen, Mei, Ron, David, Schmitt-Ulms, Gerold, Fraser, Paul E., Shneider, Neil A., Holt, Christine, Vendruscolo, Michele, Kaminski, Clemens F., and St George-Hyslop, Peter

Published
2015
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12. Classical wave thermalisation in chaotic multimode optical fibre

Author

Zanaglia, Lucas, Michel, Claire, Doya, Valérie, Picozzi, Antonio, Mortessagne, Fabrice, Garnier, Josselin, Systèmes Complexes, Académie, Idex UCA JEDI - - UCA JEDI2015 - ANR-15-IDEX-0001 - IDEX - VALID, and Complex Systems Academy

Subjects
[PHYS.PHYS.PHYS-OPTICS] Physics [physics]/Physics [physics]/Optics [physics.optics], Nonlinear optics, Wave condensation, Chaotic dynamics, Thermalisation, Wave turbulence, Multimode optical fibres, [PHYS] Physics [physics]
Published
2023

16. Retrospective, real‐life study of venetoclax plus azacitidine or low‐dose cytarabine in French patients with acute myeloid leukemia ineligible for intensive chemotherapy.

Author

Laloi, Louise, Billotey, Natacha Chaumard, Dumas, Pierre‐Yves, Paul, Franciane, Villate, Alban, Simand, Célestine, Fornecker, Luc, Puisset, Florent, Bertoli, Sarah, Simonet, Marion Boissard, Laribi, Kamel, Houyou, Dyhia, Santagostino, Alberto, Michel, Claire, Guepin, Gabrielle Roth, Guerineau, Elodie, Tabrizi, Reza, Hunault, Mathilde, Giltat, Aurélien, and Kaphan, Eléonore

Subjects
ACUTE myeloid leukemia, VENETOCLAX, CLINICAL trials, AZACITIDINE, CYTARABINE
Abstract

Background: Recently, the combination of venetoclax plus a hypomethylating agent (HMA; azacitidine ordecitabine) or low‐dose cytarabine (LDAC) showed promise in Phase III trials in previously untreated AML. In France at the time of this study, venetoclax was not yet approved for AML and there were therefore no formal usage recommendations. Here we report the first study in a French cohort that assessed venetoclax in combination with existing treatments for AML under real‐life conditions. Method: This retrospective, real‐life study collected data on venetoclax use and management in a French cohort with acute myeloid leukemia (AML) ineligible for intensive chemotherapy. Result: Of 118 patients, 81 were in second line/beyond (71.6% also hypomethylating agent [HMA]; 23.5% lowdose cytarabine [LDAC]) and 37 in first line. For venetoclax initiation, 57.3% underwent ramp up and 74.6% were hospitalized. Median venetoclax duration was 2.5 months (range 0.03‐16.2). With all treatment lines and regimens, most common grade 3/4 adverse events were hematologic (overall 96.4% of patients) and infections (57.1%). Dosage adjustments for drug interactions and safety varied between centers. In second‐line/beyond, median progression‐free survival was 4.0 months (95% confidence interval [CI] 2.7‐12.8) with venetoclax‐HMA and 3.4 months (1.3‐8.9) with venetoclax‐LDAC; overall response rate was 51.9% and 41.2%, respectively. Thus, we showed that venetoclax‐based treatment yields promising findings in patients with AML, but to address treatment complexity, practice harmonization is needed. [ABSTRACT FROM AUTHOR]

Published
2023
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19. Controlled excitation of scar modes in passive and active multimode chaotic fiber

Author

Michel, Claire, Doya, Valerie, Tascu, Sorin, Blanc, Wilfried, Legrand, Olivier, and Mortessagne, Fabrice

Subjects
Fiber optics -- Research, Wave functions -- Methods, Fiber optics, Astronomy, Physics
Abstract

A multimode optical fiber with a D-shaped cross section is an experimental paradigm of a wave system with chaotic ray dynamics. We show that seldom but usable modes, called scar modes, localized along some particular direction of the geometric trajectories, can be selectively excited. We report numerical simulations that demonstrate the importance of the so-called self-focal point in the scar mode selection process. We use a localized illumination in a passive fiber, or a localized gain in a ytterbium-doped fiber, located in the vicinity of this special point to control scar mode selection. OCIS codes: 350.5500, 060.2320.

Published
2009

20. Superfluid motion and drag-force cancellation in a fluid of light

Author

Michel, Claire, Boughdad, Omar, Albert, Mathias, Larré, Pierre-Élie, Bellec, Matthieu, Institut de Physique de Nice (INPHYNI), Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Laboratoire de Physique Théorique et Modélisation (LPTM - UMR 8089), Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), and ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)

Subjects
Condensed Matter::Quantum Gases, Physics::Fluid Dynamics, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], Science, FOS: Physical sciences, Physics::Optics, lcsh:Q, lcsh:Science, Article, Optics (physics.optics), Physics - Optics
Abstract

Quantum fluids of light merge many-body physics and nonlinear optics, revealing quantum hydrodynamic features of light when it propagates in nonlinear media. One of the most outstanding evidence of light behaving as an interacting fluid is its ability to carry itself as a superfluid. Here, we report a direct experimental detection of the transition to superfluidity in the flow of a fluid of light past an obstacle in a bulk nonlinear crystal. In this cavityless all-optical system, we extract a direct optical analog of the drag force exerted by the fluid of light and measure the associated displacement of the obstacle. Both quantities drop to zero in the superfluid regime characterized by a suppression of long-range radiation from the obstacle. The experimental capability to shape both the flow and the potential landscape paves the way for simulation of quantum transport in complex systems., Superfluidity of light enables movement without friction or, in optical terms, diffraction. Here, Michel et al. report the detection of the transition to superfluidity in the flow of a fluid of light past an obstacle in a bulk nonlinear crystal and extract the drag force exerted by the fluid of light.

Published
2018
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21. C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction

Author

Lautenschläger, Janin, Stephens, Amberley D., Fusco, Giuliana, Ströhl, Florian, Curry, Nathan, Zacharopoulou, Maria, Michel, Claire H., Laine, Romain, Nespovitaya, Nadezhda, Fantham, Marcus, Pinotsi, Dorothea, Zago, Wagner, Fraser, Paul, Tandon, Anurag, St George-Hyslop, Peter, Rees, Eric, Phillips, Jonathan J., De Simone, Alfonso, Kaminski, Clemens F., Kaminski Schierle, Gabriele S., Stephens, Amberley D [0000-0002-7303-6392], Ströhl, Florian [0000-0002-2603-0780], St George-Hyslop, Peter [0000-0003-0796-7209], Phillips, Jonathan J [0000-0002-5361-9582], Kaminski, Clemens F [0000-0002-5194-0962], Schierle, Gabriele S Kaminski [0000-0002-1843-2202], and Apollo - University of Cambridge Repository

Subjects
animal diseases, Science, Presynaptic Terminals, In Vitro Techniques, Article, Cell Line, Rats, Sprague-Dawley, Protein Aggregates, Microscopy, Electron, Transmission, mental disorders, Animals, Humans, lcsh:Science, Nuclear Magnetic Resonance, Biomolecular, Binding Sites, Lipid Metabolism, Rats, nervous system diseases, nervous system, alpha-Synuclein, lcsh:Q, Calcium, Synaptic Vesicles, Protein Binding, Synaptosomes
Abstract

Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus, which forms an amphipathic alpha-helix upon membrane interaction. Here we show that calcium binds to the C terminus of alpha-synuclein, therewith increasing its lipid-binding capacity. Using CEST-NMR, we reveal that alpha-synuclein interacts with isolated synaptic vesicles with two regions, the N terminus, already known from studies on SUVs, and additionally via its C terminus, which is regulated by the binding of calcium. Indeed, dSTORM on synaptosomes shows that calcium mediates the localization of alpha-synuclein at the pre-synaptic terminal, and an imbalance in calcium or alpha-synuclein can cause synaptic vesicle clustering, as seen ex vivo and in vitro. This study provides a new view on the binding of alpha-synuclein to synaptic vesicles, which might also affect our understanding of synucleinopathies., Alpha-synuclein is associated with neuronal dysfunction in Parkinson’s disease. This study shows that alpha-synuclein interacts with neuronal synaptic vesicles in a calcium-dependent fashion, and this interaction is important for synaptic vesicle clustering.

Published
2018

26. Experimental Observation of the Drag Force Suppression in a Flow of Superfluid Light

Author

Michel, Claire, Boughdad, Omar, Albert, Mathias, Larré, Pierre-Élie, Bellec, Matthieu, Institut de Physique de Nice (INPHYNI), Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Laboratoire Kastler Brossel (LKB [Collège de France]), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution))

Subjects
Computer Science::Robotics, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics]
Abstract

We report a direct experimental detection of the frictional-superfluid transition in the flow of a fluid of light past a weakly perturbing localized obstacle in a bulk nonlinear crystal. In our cavityless all-optical system, we extract on the one hand a direct optical analog of the drag force experienced by the obstacle and measure on the other hand the associated obstacle displacement. We observe a superfluid regime characterized by a suppression of long-range radiation from the obstacle, which is, as expected, associated to the cancellation of the drag force and the absence of displacement of the obstacle.

Published
2017

27. Advanced imaging of tau pathology in Alzheimer Disease: New perspectives from super resolution microscopy and label-free nanoscopy

Author

Schierle, Gabriele S Kaminski, Michel, Claire H, Gasparini, Laura, and Apollo - University of Cambridge Repository

Subjects
Amyloid, Microscopy, FOS: Nanotechnology, Alzheimer Disease, tauopathy, Alzheimer, Brain, Humans, Nanotechnology, tau Proteins, nanoscopy, label-free imaging, Molecular Imaging
Abstract

Alzheimer's disease (AD) is the main cause of dementia in the elderly population. Over 30 million people worldwide are living with dementia and AD prevalence is projected to increase dramatically in the next two decades. In terms of neuropathology, AD is characterized by two major cerebral hallmarks: extracellular β-amyloid (Aβ) plaques and intracellular Tau inclusions, which start accumulating in the brain 15-20 years before the onset of symptoms. Within this context, the scientific community worldwide is undertaking a wide research effort to detect AD pathology at its earliest, before symptoms appear. Neuroimaging of Aβ by positron emission tomography (PET) is clinically available and is a promising modality for early detection of Aβ pathology and AD diagnosis. Substantive efforts are ongoing to develop advanced imaging techniques for early detection of Tau pathology. Here, we will briefly describe the key features of Tau pathology and its heterogeneity across various neurodegenerative diseases bearing cerebral Tau inclusions (i.e., tauopathies). We will outline the current status of research on Tau-specific PET tracers and their clinical development. Finally, we will discuss the potential application of novel super-resolution and label-free techniques for investigating Tau pathology at the experimental level and their potential application for AD diagnosis. Microsc. Res. Tech. 79:677-683, 2016. © 2016 Wiley Periodicals, Inc.

Published
2016
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28. Emergence of rogue waves from optical turbulence

Author

Hammani , Kamal, Kibler , Bertrand, Michel , Claire, Finot , Christophe, Picozzi , Antonio, Laboratoire Interdisciplinaire Carnot de Bourgogne (LICB), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique de la matière condensée (LPMC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interdisciplinaire Carnot de Bourgogne ( LICB ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de physique de la matière condensée ( LPMC ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), and Michel, Claire

Subjects
[PHYS.PHYS.PHYS-OPTICS] Physics [physics]/Physics [physics]/Optics [physics.optics], [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], [ PHYS.PHYS.PHYS-OPTICS ] Physics [physics]/Physics [physics]/Optics [physics.optics], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011

29. Phase-space control of unconventional modes for SDM

Author

Doya, Valérie, Gustave, François, Michel, Claire, Aschieri, Pierre, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Université de Nice Sophia Antipolis, and LPMC

Subjects
[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], SDM, wave chaos
Abstract

International audience; The modes properties of highly multimode optical fibre are governed by the rays' dynamics in the geometrical limit. Different regimes of dynamics are encountered by modifying the geometry of the transverse cross section of the fibers. We show that the selection of modes in a highly multimode fiber can be simplied thanks to the signature of the rays' dynamics on the waves and exploited for spatial division multiplexing.

Published
2014

30. Suspended.

Author

Michel, Claire

Subjects
*ART awards, *VIDEOS
Abstract

The article announces video "Suspended" as winner of 2019 Ivan Juritz Prize for best visual arts.

Published
2020
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31. Turbulent Dynamics of an Incoherently Pumped Passive Optical Fibre Cavity: quasi-solitons and dispersive waves

Author

Conforti, Matteo, Mussot, Arnaud, Fatome, Julien, Pitois, Stéphane, Hammani, Kamal, Finot, Christophe, Kibler, Bertrand, Michel, Claire, Millot, Guy, Picozzi, Antonio, Finot, Christophe, Dipartimento di Ingegneria de l'Informazione, Università degli Studi di Brescia [Brescia], Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 (PhLAM), Université de Lille-Centre National de la Recherche Scientifique (CNRS), ICB-SLCO, Laboratoire Interdisciplinaire Carnot de Bourgogne (LICB), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), SLCO, Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique de la matière condensée (LPMC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Università di Brescia, Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 ( PhLAM ), Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Interdisciplinaire Carnot de Bourgogne ( LICB ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de physique de la matière condensée ( LPMC ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Università degli Studi di Brescia = University of Brescia (UniBs), Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB), and Université Nice Sophia Antipolis (1965 - 2019) (UNS)

Subjects
[PHYS.PHYS.PHYS-OPTICS] Physics [physics]/Physics [physics]/Optics [physics.optics], [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], [ PHYS.PHYS.PHYS-OPTICS ] Physics [physics]/Physics [physics]/Optics [physics.optics], Physics::Optics
Abstract

International audience; We study numerically and experimentally the dynamics of an incoherently pumped passive optical fibre ring cavity. We show that the cavity exhibits a quasi-soliton turbulence dynamics, whose properties are controlled by the degree of coherence of the injected pump wave: as the coherence of the pump is degraded, the cavity exhibits a transition from the quasi-soliton turbulent regime toward the weakly nonlinear turbulent regime characterized by short-lived rogue wave events. This behavior is reminiscent of the corresponding dynamics obtained in the purely conservative (Hamiltonian) problem. Experimental results are reported by using a standard telecommunication optical fibre system.

Published
2014

32. Phase space-based mode selection in a multimode chaotic optical fiber

Author

Doya, Valérie, Michel, Claire, Mortessagne, Fabrice, Legrand, Olivier, Laboratoire de physique de la matière condensée (LPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), and GDR MésoImage

Subjects
[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2013

33. Performance of serum biomarkers for the early detection of invasive aspergillosis in febrile, neutropenic patients: a multi-state model

Author

Schwarzinger , Michaël, Sagaon-Teyssier , Luis, Cabaret , Odile, Bretagne , Stéphane, Cordonnier , Catherine, Renseigné , Non, Pautas , Cécile, Maury , Sébastien, Hicheri , Yosr, Botterel , Françoise, Foulet , Francoise, Vekhoff , Anne, Chaoui , Driss, Cornet , Muriel, Agnamey , Patrice, Farhat , Hassan, Castaigne , Sylvie, Eloy , Odile, Suarez , Felipe, Buzyn , Agnès, Delarue , Richard, Challier , Svetlana, Dhedin , Nathalie, Aljijakli , Ahmad, Delabesse , Emmanuelle, Datry , Annick, Isnard , Françoise, Fouillard , Loic, Poirot , Jean-Yves, Meliani , Leila, Adès , Lionel, Bouges-Michel , Claire, Deniau , Michèle, Kuhnowski , Frédérique, Dreyfus , François, Paugam , André, Baixench , Marie-Thérèse, Leclercq , Roland, Reman , Oumady, Duhamel , Chantal, Bourrhis , Jean-Henri, Chehata , Sami, Chachati , Isabelle, Foissaud , Vincent, Macnab , Christine, Tilly , Hervé, Leprêtre , Stéphane, Gray , Christian, Raffoux , Emmanuel, Lacroix , Claire, Goldhaber-Fiebert , Jeremy D, Bendavid , Eran, Farley , Brandon J, Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques (U738 / UMR_S738), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Programme ATIP - Avenir, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), CHU Henri Mondor, Mycologie moléculaire, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence Mycologie et Antifongiques-Mycologie Moléculaire (CNRMA), Institut Pasteur [Paris], Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service d'hématologie clinique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Henri Mondor [Créteil], Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale ( SESSTIM - U912 INSERM - AMU - IRD ), Institut de Recherche pour le Développement ( IRD ) -Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Centre National de Référence Mycologie et Antifongiques-Mycologie Moléculaire ( CNRMA ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Laboratoire de Parasitologie-Mycologie, CHU Saint-Antoine [APHP], Thérapeutique Recombinante Expérimentale ( TIMC-IMAG-THEREX ), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications [Grenoble] ( TIMC-IMAG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -IMAG-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -IMAG-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Service des maladies infectieuses et tropicales [Rouen], CHU Rouen-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ), Laboratoire d'hématologie ( ERL 8254 ), Imagine - Institut des maladies génétiques ( IMAGINE - U1163 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Référence Déficits Immunitaires Héréditaires ( CEREDIH ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Institut Cochin ( UMR_S567 / UMR 8104 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Service d'immuno-hématologie pédiatrique [CHU Necker], Service d'hématologie clinique et de thérapie cellulaire [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Saint-Antoine [APHP], Service d'hématologie clinique [Avicenne], Université Paris 13 ( UP13 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Avicenne, Service d'hématologie, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP], CHU Cochin [AP-HP], Interactions hôte et microorganismes des épithéliums, Université de Caen Normandie ( UNICAEN ), Laboratoire de biologie médicale, Service de Santé des Armées-Hôpital d'instruction des Armées Percy, Service de Santé des Armées, Service d'oncologie, CRLCC Henri Becquerel, Groupe d'étude des proliférations lymphoïdes ( GPL ), Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service d'hématologie biologique, Assistance publique - Hôpitaux de Paris (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Macromoléculaires ( IMP-LMM ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Centre National de la Recherche Scientifique ( CNRS ), and Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris]

Subjects
Oncology, Male, Myeloid, Antifungal Agents, beta-Glucans, Epidemiology, lcsh:Medicine, Fevers, Aspergillosis, Hematologic Cancers and Related Disorders, Mannans, chemistry.chemical_compound, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, 030212 general & internal medicine, Prospective Studies, Chemotherapy-Induced Febrile Neutropenia, lcsh:Science, Prospective cohort study, DNA, Fungal, [ SDV.MP.MYC ] Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, Randomized Controlled Trials as Topic, Invasive Pulmonary Aspergillosis, 0303 health sciences, Multidisciplinary, Fungal genetics, Blood Screening, Fungal Diseases, Hematology, Middle Aged, Markov Chains, 3. Good health, Leukemia, Myeloid, Acute, medicine.anatomical_structure, Infectious Diseases, Blood, Biomarker (medicine), Medicine, Female, Research Article, Adult, medicine.medical_specialty, Antigens, Fungal, Neutropenia, Genes, Fungal, Antineoplastic Agents, Biology, Real-Time Polymerase Chain Reaction, Models, Biological, 03 medical and health sciences, Galactomannan, Internal medicine, Leukemias, medicine, Humans, Aged, Antifungals, Acute myeloid leukemia, 030306 microbiology, lcsh:R, Cancers and Neoplasms, Galactose, Fungal Polysaccharides, medicine.disease, Diagnostic medicine, Biomarker Epidemiology, Early Diagnosis, chemistry, Immunology, lcsh:Q, Biomarkers
Abstract

International audience; BACKGROUND: The performance of serum biomarkers for the early detection of invasive aspergillosis expectedly depends on the timing of test results relative to the empirical administration of antifungal therapy during neutropenia, although a dynamic evaluation framework is lacking. METHODS: We developed a multi-state model describing simultaneously the likelihood of empirical antifungal therapy and the risk of invasive aspergillosis during neutropenia. We evaluated whether the first positive test result with a biomarker is an independent predictor of invasive aspergillosis when both diagnostic information used to treat and risk factors of developing invasive aspergillosis are taken into account over time. We applied the multi-state model to a homogeneous cohort of 185 high-risk patients with acute myeloid leukemia. Patients were prospectively screened for galactomannan antigenemia twice a week for immediate treatment decision; 2,214 serum samples were collected on the same days and blindly assessed for (1->3)- β-D-glucan antigenemia and a quantitative PCR assay targeting a mitochondrial locus. RESULTS: The usual evaluation framework of biomarker performance was unable to distinguish clinical benefits of β-glucan or PCR assays. The multi-state model evidenced that the risk of invasive aspergillosis is a complex time function of neutropenia duration and risk management. The quantitative PCR assay accelerated the early detection of invasive aspergillosis (P = .010), independently of other diagnostic information used to treat, while β-glucan assay did not (P = .53). CONCLUSIONS: The performance of serum biomarkers for the early detection of invasive aspergillosis is better apprehended by the evaluation of time-varying predictors in a multi-state model. Our results provide strong rationale for prospective studies testing a preemptive antifungal therapy, guided by clinical, radiological, and bi-weekly blood screening with galactomannan antigenemia and a standardized quantitative PCR assay.

Published
2013
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34. Scedosporium apiospermum lung infection with fatal subsequent postoperative outcome in an immunocompetent host

Author

Abgrall, Sophie, Pizzocolo, Cecilia, Bouges-Michel, Claire, Martinod, Emmanuel, Martin, Antoine, Brauner, Michel, Padoin, Christophe, Karoubi, Philippe, Lortholary, Olivier, and Bouchaud, Olivier

Subjects
Lung diseases -- Care and treatment, Lung diseases -- Patient outcomes, Lung diseases -- Case studies, Lung diseases -- Diagnosis, Antifungal agents -- Usage, Health, Health care industry
Published
2007

35. A new method to determine Young's modulus of refractory

Author

De Bilbao, Emmanuel, Blond, Eric, Michel, Claire, Cutard, Thierry, Schmitt, N., Poirier, J., Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), F2ME, Laboratoire Pluridisciplinaire de Recherche en Ingénierie des Systèmes, Mécanique et Energétique (PRISME), Ecole Nationale Supérieure d'Ingénieurs de Bourges (ENSI Bourges)-Université d'Orléans (UO)-Ecole Nationale Supérieure d'Ingénieurs de Bourges (ENSI Bourges)-Université d'Orléans (UO), Institut Clément Ader (ICA), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO), Laboratoire de Mécanique et Technologie (LMT), École normale supérieure - Cachan (ENS Cachan)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), and ANR-06-MAPR-0008,DRUIDE,Durabilité des Réfractaires utilisés dans l'Incinération des Déchets(2006)

Subjects
[PHYS.MECA.MEMA]Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph], Refractory, [SPI.MECA.MEMA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph], Bending test, Modulus of Elasticity (MOE)
Abstract

International audience; This paper proposes a new method to determine the Young modulus from high temperature bending test. Considering that the global behaviour of experimental device and sample is purely elastic during the unload phase and exploiting that the effects of the indentation under the contact are lower at the beginning of the unloading, it is proposed to deduce the Young's modulus from the slope of the unloading curve. Young modulus obtained with this method for different SiC based refractories are in good agreement with results of others tests such as tensile test or ultrasonic measurement.

Published
2010

36. Advanced imaging of tau pathology in Alzheimer Disease: New perspectives from super resolution microscopy and label-free nanoscopy.

Author

Schierle, Gabriele S. Kaminski, Michel, Claire H., and Gasparini, Laura

Abstract

ABSTRACT Alzheimer's disease (AD) is the main cause of dementia in the elderly population. Over 30 million people worldwide are living with dementia and AD prevalence is projected to increase dramatically in the next two decades. In terms of neuropathology, AD is characterized by two major cerebral hallmarks: extracellular β-amyloid (Aβ) plaques and intracellular Tau inclusions, which start accumulating in the brain 15-20 years before the onset of symptoms. Within this context, the scientific community worldwide is undertaking a wide research effort to detect AD pathology at its earliest, before symptoms appear. Neuroimaging of Aβ by positron emission tomography (PET) is clinically available and is a promising modality for early detection of Aβ pathology and AD diagnosis. Substantive efforts are ongoing to develop advanced imaging techniques for early detection of Tau pathology. Here, we will briefly describe the key features of Tau pathology and its heterogeneity across various neurodegenerative diseases bearing cerebral Tau inclusions (i.e., tauopathies). We will outline the current status of research on Tau-specific PET tracers and their clinical development. Finally, we will discuss the potential application of novel super-resolution and label-free techniques for investigating Tau pathology at the experimental level and their potential application for AD diagnosis. Microsc. Res. Tech. 79:677-683, 2016. © 2016 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2016
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38. BRCA1 Haploinsufficiency Leads to Altered Expression of Genes Involved in Cellular Proliferation and Development.

Author

Feilotter, Harriet E., Michel, Claire, Uy, Paolo, Bathurst, Lauren, and Davey, Scott

Subjects
*GENE expression, *CELL proliferation, *CELL growth, *GENETIC code, *NUCLEOTIDE sequence, *GENETIC mutation, *BREAST cancer
Abstract

The assessment of BRCA1 and BRCA2 coding sequences to identify pathogenic mutations associated with inherited breast/ovarian cancer syndrome has provided a method to identify high-risk individuals, allowing them to seek preventative treatments and strategies. However, the current test is expensive, and cannot differentiate between pathogenic variants and those that may be benign. Focusing only on one of the two BRCA partners, we have developed a biological assay for haploinsufficiency of BRCA1. Using a series of EBV-transformed cell lines, we explored gene expression patterns in cells that were BRCA1 wildtype compared to those that carried (heterozygous) BRCA1 pathogenic mutations. We identified a subset of 43 genes whose combined expression pattern is a sensitive predictor of BRCA1 status. The gene set was disproportionately made up of genes involved in cellular differentiation, lending credence to the hypothesis that single copy loss of BRCA1 function may impact differentiation, rendering cells more susceptible to undergoing malignant processes. [ABSTRACT FROM AUTHOR]

Published
2014
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39. Lymphedema: An Overview.

Author

MCGUIRE, JAMES and MICHEL, CLAIRE-IPHANISE

Abstract

The article discusses the medical condition lymphedema caused by lymphatic system dysfunction or the body's inability to remove excess fluid from the extremities or other organs. Topics covered include the condition's pathophysiology, its types, signs, symptoms, and diagnosis, and its manifestation of skin changes. Also noted is lymphedema's conservative, surgical, and medical treatments.

Published
2018

40. Severely Hyperammonemic Acute Liver Failure due to Paracetamol Overdose: The Impact of High-Intensity Continuous Renal Replacement Therapy.

Author

Chaba, Anis, Warrillow, Stephen Joseph, Fisher, Caleb, Spano, Sofia, Maeda, Akinori, Phongphithakchai, Atthaphong, Pattamin, Nuttapol, Hikasa, Yukiko, Kitisin, Nuanprae, Warming, Scott, Michel, Claire, Eastwood, Glenn M., and Bellomo, Rinaldo

Abstract

Introduction: Paracetamol (acetaminophen)-induced acute liver failure (ALF) with severe hyperammonemia (ammonia >100 µmol⋅L−1) is a life-threatening condition. A strategy based on high-intensity continuous renal replacement therapy (CRRT) without early (up to day seven) transplantation may enable clinicians to safely identify which patients can recover and survive and which patients require transplantation. Methods: We conducted a single-center, retrospective cohort study of patients with severely hyperammonemic paracetamol-induced ALF. The primary outcome was early transplant-free survival. Results: We studied 84 patients (median age: 38; female sex: 79 [85%]) over a 12-year period (median ammonia level at ICU admission: 153 µmol⋅L−1; median peak aspartate aminotransferase (AST): 10,029 U⋅L−1; median lactate: 5.0 mmol⋅L−1; and median INR: 4.4) and 55 (65%) with King’s College criteria for transplantation. Overall, 87% received high-intensity CRRT (92% in 2020–2023). Median CRRT intensity was 54 mL⋅kg−1⋅hr−1 within the first 48 h and increased by 1.8 mL⋅kg−1⋅hr−1 per year during the study period (p = 0.002). Transplant-free survival to day 7 was 86% in 2011–2023 and 96% in 2020–2023. Overall, only 4 patients were transplanted and only 1 (4%) in 2020–2023. On multivariable Cox analysis, factors independently associated with failure to achieve day seven transplant-free survival were higher APACHE III score (HR = 1.05, 95% CI: 1.02–1.08), higher lactate (HR = 1.27, 95% CI: 1.12–1.44), and lower platelet count at ICU admission (HR = 0.85, 95% CI: 0.78–0.93) and the median effluent dose applied within the first 48 h of ICU admission (HR = 0.67, 95% CI: 0.46–0.98). Conclusions: Early transplant-free survival is achievable in most patients with paracetamol-induced ALF and severe hyperammonemia with a treatment based on high-intensity CRRT. Such transplant-free survival increased over time together with increased CRRT dose. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Temporal incoherent solitons supported by a defocusing nonlinearity with anomalous dispersion.

Author

Michel, Claire, Kibler, Bertrand, Garnier, Josselin, and Picozzi, Antonio

Subjects
*SOLITONS, *NONLINEAR theories, *DISPERSION (Chemistry), *WAVE packets, *VLASOV equation, *LIMIT theorems
Abstract

We study temporal incoherent solitons in noninstantaneous response nonlinear media. Contrarily to the usual temporal soliton, which is known to require a focusing nonlinearity with anomalous dispersion, we show that a highly noninstantaneous nonlinear response leads to incoherent soliton structures which require the inverted situation: In the focusing regime (and anomalous dispersion) the incoherent wave packet experiences an unlimited spreading, whereas in the defocusing regime (still with anomalous dispersion) the incoherent wave packet exhibits a self-trapping. These counterintuitive results are explained in detail by a long-range Vlasov formulation of the problem. [ABSTRACT FROM AUTHOR]

Published
2012
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43. Discrete spectral incoherent solitons in nonlinear media with noninstantaneous response.

Author

Michel, Claire, Kibler, Bertrand, and Picozzi, Antonio

Subjects
*NONLINEAR theories, *SOLITONS, *FREQUENCY spectra, *SPECTRUM analysis, *SPEED, *RAMAN effect, *LIGHT scattering
Abstract

We show theoretically that nonlinear optical media characterized by a finite response time may support the existence of discrete spectral incoherent solitons. The structure of the soliton consists of three incoherent spectral bands that propagate in frequency space toward the low-frequency components in a discrete fashion and with a constant velocity. Discrete spectral incoherent solitons do not exhibit a confinement in the space-time domain, but exclusively in the frequency domain. The kinetic theory describes in detail all the essential properties of discrete spectral incoherent solitons: A quantitative agreement has been obtained between simulations of the kinetic equation and the nonlinear Schrödinger equation. Discrete spectral incoherent solitons may be supported in both the normal dispersion regime or the anomalous dispersion regime. These incoherent structures find their origin in the causality condition inherent to the nonlinear response function of the material. Considering the concrete example of the Raman effect, we show that discrete incoherent solitons may be spontaneously generated through the process of supercontinuum generation in photonic crystal fibers. [ABSTRACT FROM AUTHOR]

Published
2011
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44. Candidemia: A Nosocomial Complication in Adults with Late-Stage AIDS.

Author

Launay, Odile, Lortholary, Olivier, Bouges-Michel, Claire, Jarrousse, Bernard, Bentata, Michéle, and Guillevin, Loïc

Abstract

We retrospectively analyzed 13 episodes of candidemia observed between July 1990 and July 1995 in human immunodeficiency virus (HIV)-infected adults. Candidemia was nosocomially acquired by 11 patients, among whom nine had a central venous catheter (CVC). Twelve cases were of stage C2/C3 according to the 1993 classification of the Centers for Disease Control and Prevention. The median CD4+ cell count was 10/mm3 (range, 3–400/mm3). Causative species were Candida albicans in nine episodes and Candida glabrata and Candida krusei in two episodes each. Eleven episodes occurred in 11 patients who had previously received fluconazole (mean total dose, 7.4 g), including the four episodes caused by non-albicans species. Outcome did not differ according to the administered antifungal therapy. CVCs were removed from seven patients (78%). The overall mortality was 38%. Candidemia is a potentially lethal nosocomial complication during late-stage AIDS and can be due to C. albicans and non-albicans strains. [ABSTRACT FROM PUBLISHER]

Published
1998

45. Aspergillus Pericarditis with Tamponade: Report of a Successfully Treated Case and Review.

Author

Moing, Vincent Le, Lortholary, Olivier, Timsit, Jean-François, Couvelard, Anne, Bouges-Michel, Claire, Wolff, Michel, Guillevin, Loïc, and Casassus, Philippe

Abstract

We report a case of aspergillus pericarditis with tamponade complicating invasive pulmonary aspergillosis in a patient treated for acute lymphocytic leukemia. Prolonged antifungal therapy and aggressive surgical treatment cured the pericarditis, without relapse, despite the fact that the patient underwent autologous bone marrow transplantation. In a review of 28 other cases of aspergillus pericarditis, we found that this condition usually had occurred in severely immunocompromised patients and was always the result of contiguous dissemination of Aspergillus from the lung or myocardium. Tamponade was present in eight of 29 patients. Aspergillus antigen was detected in the pericardial fluid of all three patients whose fluid specimens were tested. Aspergillus pericarditis was diagnosed before death in 10 of 29 patients, all of whom had established premortem diagnoses of invasive aspergillosis at other sites and had received antifungal therapy. Three of the four survivors received combined medical and aggressive surgical therapies. The performance of echocardiography early during the course of invasive pulmonary aspergillosis, together with intensive combined therapies, might lower the high mortality associated with aspergillus pericarditis. [ABSTRACT FROM PUBLISHER]

Published
1998

46. C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction

Author

Lautenschläger, Janin, Stephens, Amberley D., Fusco, Giuliana, Ströhl, Florian, Curry, Nathan, Zacharopoulou, Maria, Michel, Claire H., Laine, Romain, Nespovitaya, Nadezhda, Fantham, Marcus, Pinotsi, Dorothea, Zago, Wagner, Fraser, Paul, Tandon, Anurag, St George-Hyslop, Peter, Rees, Eric, Phillips, Jonathan J., De Simone, Alfonso, Kaminski, Clemens F., and Kaminski Schierle, Gabriele S.

Subjects
nervous system, animal diseases, nervous system diseases, 3. Good health
Abstract

Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus, which forms an amphipathic alpha-helix upon membrane interaction. Here we show that calcium binds to the C terminus of alpha-synuclein, therewith increasing its lipid-binding capacity. Using CEST-NMR, we reveal that alpha-synuclein interacts with isolated synaptic vesicles with two regions, the N terminus, already known from studies on SUVs, and additionally via its C terminus, which is regulated by the binding of calcium. Indeed, dSTORM on synaptosomes shows that calcium mediates the localization of alpha-synuclein at the pre-synaptic terminal, and an imbalance in calcium or alpha-synuclein can cause synaptic vesicle clustering, as seen ex vivo and in vitro. This study provides a new view on the binding of alpha-synuclein to synaptic vesicles, which might also affect our understanding of synucleinopathies., Nature Communications, 9, ISSN:2041-1723

49. Pneumocystosis: Survey and DHPS Genotype Analysis in 14 Parisian Hospitals in 2003 and 2004.

Author

MAGNE, DENIS, LACUBE, PHILIPPE, ANGOULVANT, ADELA, MELIANI, LEILA, BOTTEREL, FRANCOISE, BOUGNOUX, MARIE-ELISABETH, CHOCHILLON, CHRISTIAN, CORNET, MURIEL, DANNAOUI, ERIC, DATRY, ANNICK, DUNAND, JEAN, GALEAZZI, GUY, BOUGES-MICHEL, CLAIRE, YERA, HELENE, SARFATI, CLAUDINE, and ROUX, PATRICIA

Subjects
HEALTH surveys, PNEUMOCYSTIS pneumonia, HIV-positive persons, DRUG resistance
Abstract

The article presents a survey of pneumocystosis and dihydropteroate synthase genotype (DHPS) analysis in Parisian hospitals in France in 2003 and 2004. From January 1, 2003 to December 31, 2004, 313 Pneumocystis pneumonia cases were reported, 150 in 2003 and 163 in 2004. Sixty-five percent of the patients were HIV positive, where men represented 66% of the total patients. In addition, there was evidence that the prevalence of DHPS mutations depends on geographic locations.

Published
2006
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50. In situ studies of protein aggregation kinetics with multiparametric and superresolution imaging.

Author

Schierle, Gabriele Kaminski, Michel, Claire, Rees, Eric, Pinotsi, Dorothea, and Kaminski, Clemens

Subjects
*HIGH resolution imaging, *NEURODEGENERATION, *BIOLOGICAL aggregation
Abstract

An abstract of the article " In situ studies of protein aggregation kinetics with multiparametric and superresolution imaging" by Gabriele Kaminski Schierle and colleagues is presented.

Published
2013
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