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Your search keyword '"Michael R. Buchanan"' showing total 2 results
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2 results on '"Michael R. Buchanan"'

1. Microcirculation in Cancer Metastasis

Author

F. William Orr, Michael R. Buchanan, Leonard Weiss, F. William Orr, Michael R. Buchanan, and Leonard Weiss

Subjects
Metastasis, Microcirculation, Cancer invasiveness, Lymphatic metastasis, Microcirculation--physiopathology, Neoplasm Metastasis
Abstract

Although mechanisms involved in the spread of cancer have been the subject of a major research endeavor over the past decade, metastatic tumors still account for significant clinical morbidity and the failure of cancer treatment. Not only are the vascular pathways the most common route for the dissemination of cancer cells, but interactions between the cells and the circulation act as important rate-regulators for the metastatic process.This authoritative, multi-authored volume addresses the importance of microcirculation in cancer metastasis. The book begins with up-to-date reviews on the biology of endothelial cells and the structure and physiology of the normal and tumor microcirculations, and then emphasizes interactions between components of the microcirculation and cancer cells. Metastasis is discussed through chapters exploring the entry of cancer cells into the circulation, the biophysics and morphology of cancer cell traffic and arrest, interactions with host cells and the basement membranes, and angiogenesis. This fascinating book will interest oncologists, pathologists, and students of metastasis or the microcirculation.

Published
2024

2. The thrombolytic and hemorrhagic effects of tissue type plasminogen activator: influence of dosage regimens in rabbits

Author

F Fernandez, Giancarlo Agnelli, Jack Hirsh, and Michael R. Buchanan

Subjects
medicine.medical_specialty, Time Factors, medicine.medical_treatment, Hemorrhage, Tissue plasminogen activator, Alpha 2-antiplasmin, Fibrinolysis, medicine, Thrombolytic Agent, Animals, Infusions, Parenteral, Saline, alpha-2-Antiplasmin, Dose-Response Relationship, Drug, business.industry, Thrombosis, Hematology, Thrombolysis, medicine.disease, Recombinant Proteins, Surgery, Kinetics, Anesthesia, Tissue Plasminogen Activator, Rabbits, Jugular Veins, business, Plasminogen activator, medicine.drug
Abstract

Tissue type plasminogen activator (t-PA) is an effective thrombolytic agent in experimental animals and in humans. We have previously observed that the thrombolytic effect of t-PA persists beyond its time of clearance from the circulation and that wound bleeding induced by a high dose infusion of t-PA is delayed for at least one and a half hours after commencing the infusion. These observations suggest that improved thrombolysis may be obtained with t-PA by infusing a high dose over a short period of time. To test this hypothesis we compared the thrombolytic and hemorrhagic effects of t-PA infused over 240, 60, 30 and 15 minutes in the rabbit. A 4 hour infusion of 30,000 U/kg of t-PA produced 36% thrombolysis. The same dose of t-PA infused over 60, 30 and 15 minutes produced 87%, 88% and 96% thrombolysis, respectively (p less than 0.01). The 1 hour infusion of 30,000 U/kg of t-PA produced a significant increase in blood loss relative to saline infusion (p less than 0.01). The same dose infused over 30 and 15 minutes did not produce significantly more bleeding than saline. A higher dose of t-PA, 60,000 U/kg, infused over 4 hours, produced 95% thrombolysis, but was associated with a significant increase of blood loss (p less than 0.001). Our findings suggest that improved thrombolysis with t-PA with minimal bleeding side-effects is achieved in rabbits when t-PA is administered in a relatively high dose given over a short period of time.

Published
1985

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