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Southern Africa is typically considered to belong to a single tectonic plate, Nubia, despite active faulting along the southwestern branch of the East African Rift System. We analyze regional Global Navigation Satellite System (GNSS) measurements, and find that the “San” microplate, situated south of the southwestern branch of the East African Rift, is statistically distinct from Nubia, with 0.4–0.7 mm/yr of extension across the boundary. Adding nine new campaign GNSS sites, we show that the extension rate across the southern Malawi Rift is 2.2 ± 0.3 mm/yr, with 75% of the relative velocity occurring over 890 km, despite the surface expression of faulting being

Being a part of ongoing continental collision between the Arabian and Eurasian plates, the Caucasus region is a remarkable site of moderate to strong seismicity, where devastating earthquakes caused significant losses of lives and livelihood. In this article, we survey geology and geodynamics of the Caucasus and its surroundings; magmatism and heat flow; active tectonics and tectonic stresses caused by the collision and shortening; gravity and density models; and overview recent geodetic studies related to regional movements. The tectonic development of the Caucasus region in the Mesozoic-Cenozoic times as well as the underlying dynamics controlling its development are complicated processes. It is clear that the collision is responsible for a topographic uplift / inversion and for the formation of the fold-and-thrust belts of the Greater and Lesser Caucasus. Tectonic deformations in the region is influenced by the wedge-shaped rigid Arabian block indenting into the relatively mobile region and producing near N-S compressional stress and seismicity in the Caucasus. Regional seismicity is analysed with an attention to sub-crustal seismicity under the northern foothills of the Greater Caucasus, which origin is unclear – whether the seismicity associated with a descending oceanic crust or thinned continental crust. Recent seismic tomography studies are in favour of the detachment of a lithospheric root beneath the Lesser and Greater Caucasus. The knowledge of geodynamics, seismicity, and stress regime in the Caucasus region assists in an assessment of seismic hazard and risk. We look finally at existing gaps in the current knowledge and identify the problems, which may improve our understanding of the regional evolution, active tectonics, geodynamics, shallow and deeper seismicity, and surface manifestations of the lithosphere dynamics. Among the gaps are those related to uncertainties in regional geodynamic and tectonic evolution (e.g., continental collision and associated shortening and exhumation, lithosphere structure, deformation and strain-stress partitioning) and to the lack of comprehensive datasets (e.g., regional seismic catalogues, seismic, gravity and geodetic surveys).

Forming of composite laminates is an effective manufacturing method that improves repeatability, enables tailoring of material orientations, and reduces time and cost when compared to more labour-intensive alternatives. However, this process is often prone to defects - leading to delays and ultimately scrapping of expensive parts - that are traditionally mitigated through resource intensive trial and error approaches. The risks of the forming process can be mitigated by using process simulation as a tool to develop a robust process window. In order to successfully model the forming of composite materials, the relevant deformation mechanisms and material attributes, shown in Figure 1, need to be considered. This paper presents a finite element simulation framework to predict the occurrence of defects in the forming and consolidation steps of the manufacturing process of fibre reinforced composites. The modelling approach presents a novel discretization strategy for each ply with a superposition of solid and shell elements. This solution uses a coupled pressure-displacement implicit analysis procedure that allows for the simulation of resin flow and is well suited to simulate autoclave consolidation and simple forming cases where through-thickness deformations are important. Simulation results show good agreement with experimental forming trials and other work found in literature in terms of deformation mechanisms and defects observed., 34th Technical Conference of the American Society for Composites, ASC 2019, September 23-25, 2019, Atlanta, USA

BACKGROUND: Human immunodeficiency virus (HIV)–infected individuals are at increased risk of age-associated functional impairment, even with effective antiretroviral therapy (ART). A concurrent characterization of skeletal muscle, physical function, and immune phenotype in aviremic middle-aged HIV-infected adults represents a knowledge gap in prognostic biomarker discovery. METHODS: We undertook a prospective observational study of 170 middle-aged, HIV-infected ambulatory men and women with CD4(+) T-cell counts of at least 350/µL and undetectable plasma viremia while on effective ART, and uninfected control participants. We measured biomarkers for inflammation and immune activation, fatigue, the Veterans Aging Cohort Study mortality index, and physical function. A subset also received a skeletal muscle biopsy and computed tomography scan. RESULTS: Compared to the uninfected participants, HIV-infected participants displayed increased immune activation (P < .001), inflammation (P = .001), and fatigue (P = .010), and in a regression model adjusting for age and sex displayed deficits in stair-climb power (P < .001), gait speed (P = .036), and predicted metabolic equivalents (P = .019). Skeletal muscle displayed reduced nuclear peroxisome proliferator-activated receptor-γ coactivator 1α–positive myonuclei (P = .006), and increased internalized myonuclei (P < .001) that correlated with immune activation (P = .003) and leukocyte infiltration (P < .001). Internalized myonuclei improved a model for HIV discrimination, increasing the C-statistic from 0.84 to 0.90. CONCLUSIONS: Asymptomatic HIV-infected middle-aged adults display atypical skeletal muscle profiles, subclinical deficits in physical function, and persistent inflammation and immune activation. Identifying biomarker profiles for muscle dysregulation and risk for future functional decline in the HIV-infected population will be key to developing and monitoring preventive interventions. CLINICAL TRIALS REGISTRATION: NCT03011957.

Historical accounts describe an earthquake and tsunami on 21 July AD 365 that destroyed cities and drowned thousands of people in coastal regions from the Nile Delta to modern-day Dubrovnik. The location and tectonic setting of this earthquake have been uncertain until now. Here, we present evidence from radiocarbon data and field observations that western Crete was lifted above sea level, by up to 10 m, synchronously with the AD 365 earthquake. The distribution of uplift, combined with observations of present-day seismicity, suggest that this earthquake occurred not on the subduction interface beneath Crete, but on a fault dipping at about 30∘ within the overriding plate. Calculations of tsunami propagation show that the uplift of the sea floor associated with such an earthquake would have generated a damaging tsunami through much of the eastern Mediterranean. Measurement of the present rate of crustal shortening near Crete yields an estimate of ∼5,000 yr for the repeat time of tsunamigenic events on this single fault in western Crete, but if the same process takes place along the entire Hellenic subduction zone, such events may occur approximately once every 800 yr. In the year AD 365, an earthquake and tsunami destroyed much of the eastern Mediterranean coastal regions. The distribution of uplift at the time suggests that the earthquake occurred on a fault within the overriding plate at the subduction zone beneath Crete, and not on the subduction interface itself.

To gain insight into the large toughness variability observed between metallic glasses (MGs), we examine the origin of fracture toughness through bending experiments and molecular dynamics (MD) simulations for two binary MGs: Pd_(82)Si_(18) and Cu_(46)Zr_(54). The bending experiments show that Pd_(82)Si_(18) is considerably tougher than Cu_(46)Zr_(54), and the higher toughness of Pd_(82)Si_(18) is attributed to an ability to deform plastically in the absence of crack nucleation through cavitation. The MD simulations study the initial stages of cavitation in both materials and extract the critical factors controlling cavitation. We find that for the tougher Pd_(82)Si_(18), cavitation is governed by chemical inhomogeneity in addition to topological structures. In contrast, no such chemical correlations are observed in the more brittle Cu_(46)Zr_(54), where topological low coordination number polyhedra are still observed around the critical cavity. As such, chemical inhomogeneity leads to more difficult cavitation initiation in Pd_(82)Si_(18) than in Cu_(46)Zr_(54), leading to a higher toughness. The absence of chemical separation during cavitation initiation in Cu_(46)Zr_(54) decreases the energy barrier for a cavitation event, leading to lower toughness.

Calderas are formed by the collapse of large magma reservoirs and are commonly elliptical in map view. The orientation of elliptical calderas is often used as an indicator of the local stress regime; but, in some rift settings, pre-existing structural trends may also influence the orientation. We investigated whether either of these two mechanisms controls the orientation of calderas in the Kenyan Rift. Satellite-based mapping was used to identify the rift border faults, intra-rift faults and orientation of the calderas to measure the stress orientations and pre-existing structural trends and to determine the extensional regime at each volcano. We found that extension in northern Kenya is orthogonal, whereas that in southern Kenya is oblique. Elliptical calderas in northern Kenya are orientated NW–SE, aligned with pre-existing structures and perpendicular to recent rift faults. In southern Kenya, the calderas are aligned NE–SW and lie oblique to recent rift faults, but are aligned with pre-existing structures. We conclude that, in oblique continental rifts, pre-existing structures control the development of elongated magma reservoirs. Our results highlight the structural control of magmatism at different crustal levels, where pre-existing structures control the storage and orientation of deeper magma reservoirs and the local stress regime controls intra-rift faulting and shallow magmatism. Supplementary material: Details of the Standard Deviation Ellipse function and statistical methods are available at http://www.geolsoc.org.uk/SUP18849 .

International audience; Over the past two decades, geophysical observations have shown that earthquakes can trigger other earthquakes, raising the possibility that earthquake interaction plays an important role in the earth's deformation. We analyze here a "storm" of earthquakes in Greece and show that their interaction provides remarkable insight into the mechanics of one of the fastest deforming continental region in the world. A rupture of the African slab initiates a cascade of large earthquakes and a long episode of slow slip marking the downward plunge of the slab, the concomitant rollback of the subduction, and the subsequent detachment of southern Greece from the Eurasian plate. Intense crustal deformation, indicative of the resulting plate stretching, follows. This slow deformation which spreads in a few months over more than 500 km lasts~3 years and triggers earthquakes. The observations also show that the retreat of the African subduction is the motor of the Aegean deformation.

Bulk-metallic glasses (BMGs) are now candidate materials for structural applications due to their exceptional strength and toughness. However, their fatigue resistance can be poor and inconsistent, severely limiting their potential as reliable structural materials. As fatigue limits are invariably governed by the local arrest of microscopically small cracks at microstructural features, the lack of microstructure in monolithic glasses, often coupled with other factors, such as the ease of crack formation in shear bands or a high susceptibility to corrosion, can lead to low fatigue limits (some ∼1/20 of their tensile strengths) and highly variable fatigue lives. BMG-matrix composites can provide a solution here as their duplex microstructures can arrest shear bands at a second phase to prevent cracks from exceeding critical size; under these conditions, fatigue limits become comparable with those of crystalline alloys. Here, we report on a Pd-based glass that similarly has high fatigue resistance but without a second phase. This monolithic glass displays high intrinsic toughness from extensive shear-band proliferation with cavitation and cracking effectively obstructed. We find that this property can further promote fatigue resistance through extrinsic crack-tip shielding, a mechanism well known in crystalline metals but not previously reported in BMGs, whereby cyclically loaded cracks propagate in a highly “zig-zag” manner, creating a rough “staircase-like” profile. The resulting crack-surface contact (roughness-induced crack closure) elevates fatigue properties to those comparable to crystalline alloys, and the accompanying plasticity helps to reduce flaw sensitivity in the glass, thereby promoting structural reliability.

An alloy development strategy coupled with toughness assessments and ultrasonic measurements is implemented to design a series of iron-based glass-forming alloys that demonstrate improved glass-forming ability and toughness. The combination of good glass-forming ability and high toughness demonstrated by the present alloys is uncommon in Fe-based systems, and is attributed to the ability of these compositions to form stable glass configurations associated with low activation barriers for shear flow, which tend to promote plastic flow and give rise to a toughness higher than other known Fe-based bulk-glass-forming systems.