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8. Randomized controlled trial between conventional versus sutureless bioprostheses for aortic valve replacement: Impact of mini and full sternotomy access at 1-year follow-up

Author

Fischlein, Theodor, Caporali, Elena, Folliguet, Thierry, Kappert, Utz, Meuris, Bart, Shrestha, Malakh L., Roselli, Eric E., Bonaros, Nikolaos, Fabre, Olivier, Corbi, Pierre, Troise, Giovanni, Andreas, Martin, Pinaud, Frederic, Pfeiffer, Steffen, Kueri, Sami, Tan, Erwin, Voisine, Pierre, Girdauskas, Evaldas, Rega, Filip, García-Puente, Julio, and Lorusso, Roberto

Published
2022
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9. Midterm outcomes with a sutureless aortic bioprosthesis in a prospective multicenter cohort study

Author

Zannis, Kostantinos, Pfeiffer, Steffen, Santarpino, Giuseppe, Shrestha, Malakh, Sarikouch, Samir, Gummert, Jan F., Mohr, Friedrich W., Dohmen, Pascal, Stalder, Mario, Roost, Eva, Filipiak, Krzysztof, Niklewski, Tomasz, Madonna, Francesco, Roques, Xavier, Flameng, Willem J., Laczkovics, Axel M.M., Bechtel, Matthias, Prat, Alain G., Banfi, Carlo, Dapunt, Otto E., Eichstaedt, Harald C., Harringer, Wolfgang, Carstens-Fitz, Ulrike, Spyt, Tom J., Wimmer-Greinecker, Jan Gerhard, Machner, Matthias, Tan, Erwin S.H., Casselman, Filip P.A., Yilmaz, Alaaddin, Sonker, Uday, Bleiziffer, Sabine, Oberwalder, Peter J., Kocher, Alfred A., Seitelberger, Rainald, Treede, Hendrik, Conradi, Leonard, Cocchieri, Riccardo, De Mol, Bas, Roussel, Jean-Christian, Despins, Philippe, Jakob, Heinz G., Wendt, Daniel, Fischlein, Theodor, Meuris, Bart, Folliguet, Thierry, Hakim-Meibodi, Kavous, Misfeld, Martin, Carrel, Thierry, Zembala, Marian, Cerutti, Elisa, Asch, Federico M., and Haverich, Axel

Published
2022
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10. Sutureless Versus Rapid Deployment Aortic Valve Replacement: Results From a Multicenter Registry

Author

Berretta, Paolo, Meuris, Bart, Kappert, Utz, Andreas, Martin, Fiore, Antonio, Solinas, Marco, Misfeld, Martin, Carrel, Thierry P., Villa, Emmanuel, Savini, Carlo, Santarpino, Giuseppe, Teoh, Kevin, Albertini, Alberto, Fischlein, Theodor, Martinelli, Gianluca, Mignosa, Carmelo, Glauber, Mattia, Shrestha, Malak, Laufer, Ghunter, Phan, Kevin, Yan, Tristan, and Di Eusanio, Marco

Published
2022
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12. Long-term outcome after the Ross procedure in 173 adults with up to 25 years of follow-up.

Author

Hoof, Lucas Van, Rooyackers, Bert, Schuermans, Art, Duponselle, Jolien, Bruaene, Alexander Van De, Meester, Pieter De, Troost, Els, Meuris, Bart, Budts, Werner, Gewillig, Marc, Flameng, Willem, Daenen, Willem, Meyns, Bart, Verbrugghe, Peter, and Rega, Filip

Subjects
AORTIC valve diseases, YOUNG adults, AORTIC valve insufficiency, UNIVERSITY hospitals, REGRESSION analysis
Abstract

OBJECTIVES The potential risk of autograft dilatation and homograft stenosis after the Ross procedure mandates lifelong follow-up. This retrospective cohort study aimed to determine long-term outcome of the Ross procedure, investigating autograft and homograft failure patterns leading to reintervention. METHODS All adults who underwent the Ross procedure between 1991 and 2018 at the University Hospitals Leuven were included, with follow-up data collected retrospectively. Autograft implantation was performed using the full root replacement technique. The primary end-point was long-term survival. Secondary end-points were survival free from any reintervention, autograft or homograft reintervention-free survival, and evolution of autograft diameter, homograft gradient and aortic regurgitation grade over time. RESULTS A total of 173 adult patients (66% male) with a median age of 32 years (range 18–58 years) were included. External support at both the annulus and sinotubular junction was used in 38.7% (67/173). Median follow-up duration was 11.1 years (IQR, 6.4–15.9; 2065 patient-years) with 95% follow-up completeness. There was one (0.6%) perioperative death. Kaplan–Meier estimate for 15-year survival was 91.1% and Ross-related reintervention-free survival was 75.7% (autograft: 83.5%, homograft: 85%). Regression analyses demonstrated progressive neoaortic root dilatation (0.56 mm/year) and increase in homograft gradient (0.72 mmHg/year). CONCLUSIONS The Ross procedure has the potential to offer excellent long-term survival and reintervention-free survival. These long-term data further confirm that the Ross procedure is a suitable option in young adults with aortic valve disease which should be considered on an individual basis. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Correction to: European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria

Author

Biancari, Fausto, Mariscalco, Giovanni, Yusuff, Hakeem, Tsang, Geoffrey, Luthra, Suvitesh, Onorati, Francesco, Francica, Alessandra, Rossetti, Cecilia, Perrotti, Andrea, Chocron, Sidney, Fiore, Antonio, Folliguet, Thierry, Pettinari, Matteo, Dell’Aquila, Angelo M., Demal, Till, Conradi, Lenard, Detter, Christian, Pol, Marek, Ivak, Peter, Schlosser, Filip, Forlani, Stefano, Chetty, Govind, Harky, Amer, Kuduvalli, Manoj, Field, Mark, Vendramin, Igor, Livi, Ugolino, Rinaldi, Mauro, Ferrante, Luisa, Etz, Christian, Noack, Thilo, Mastrobuoni, Stefano, De Kerchove, Laurent, Jormalainen, Mikko, Laga, Steven, Meuris, Bart, Schepens, Marc, Dean, Zein El, Vento, Antti, Raivio, Peter, Borger, Michael, and Juvonen, Tatu

Published
2021
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22. European registry of type A aortic dissection (ERTAAD) - rationale, design and definition criteria

Author

Biancari, Fausto, Mariscalco, Giovanni, Yusuff, Hakeem, Tsang, Geoffrey, Luthra, Suvitesh, Onorati, Francesco, Francica, Alessandra, Rossetti, Cecilia, Perrotti, Andrea, Chocron, Sidney, Fiore, Antonio, Folliguet, Thierry, Pettinari, Matteo, Dell’Aquila, Angelo M., Demal, Till, Conradi, Lenard, Detter, Christian, Pol, Marek, Ivak, Peter, Schlosser, Filip, Forlani, Stefano, Chetty, Govind, Harky, Amer, Kuduvalli, Manoj, Field, Mark, Vendramin, Igor, Livi, Ugolino, Rinaldi, Mauro, Ferrante, Luisa, Etz, Christian, Noack, Thilo, Mastrobuoni, Stefano, De Kerchove, Laurent, Jormalainen, Mikko, Laga, Steven, Meuris, Bart, Schepens, Marc, El Dean, Zein, Vento, Antti, Raivio, Peter, Borger, Michael, and Juvonen, Tatu

Published
2021
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24. AVIATOR: An open international registry to evaluate medical and surgical outcomes of aortic valve insufficiency and ascending aorta aneurysm

Author

Dinges, Christian, Steindl, Johannes, Ziller, Rosina, De Kerchove, Laurent, Benkacem, Taoufik, Coulon, Corinne, Elkhoury, Gebrine, Kaddouri, Fadoua, Vanoverschelde, Jean-Louis, de Meester, Christophe, Pasquet, Agnès, Nijs, Jan, Van Mosselvelde, Veerle, Loeys, Bart, Meuris, Bart, Schepmans, Evi, Van den Bossche, Klaartje, Verbrugghe, Peter, Goossens, Wenke, Gutermann, Herbert, Pettinari, Matteo, El-Hamamsy, Ismail, Lenoir, Marien, Noly, Pierre-Emmanuel, Tousch, Michael, Shah, Pallav, Boodhwani, Munir, Rudez, Igor, Baric, Davor, Unic, Daniel, Varvodic, Josip, Gjorgijevska, Savica, Vojacek, Jan, Zacek, Pavel, Karalko, Mikita, Hlubocky, Jaroslav, Novotny, Robert, Slautin, Andrey, Soliman, Said, Arnaud-Crozat, Eric, Boignard, Aude, Fayad, Georges, Bouchot, Olivier, Albat, Bernard, Leguerrier, Alain, Doguet, Fabien, Fuzellier, Jean-François, Glock, Yves, Jondeau, Guillaume, Fernandez, Guy, Chatel, Didier, Zeitoun, David Messika, Jouan, Jérôme, Di Centa, Isabelle, Obadia, Jean-François, Leprince, Pascal, Houel, Rémi, Bergoend, Eric, Lopez, Stéphane, Berrebi, Alain, Tubach, Florence, Lansac, Emmanuel, Lejeune, Stéphanie, Monin, Jean-Luc, Pousset, Sarah, Mankoubi, Leila, Noghin, Milean, Diakov, Christelle, Czytrom, Daniel, Schäfers, Hans-Joachim, Borger, Michael, Aicher, Diana, Theisohn, Frank, Ferrero, Paolo, Stoica, Serban, Matuszewski, Maciej, Yiu, Patrick, Bashir, Mohamad, Ceresa, Fabrizio, Patane, Francesco, De Paulis, Ruggero, Chirichilli, Ilaria, Masat, Mauro, Antona, Carlo, Contino, Monica, Mangini, Andrea, Romagnoni, Claudia, Grigioni, Francesco, Rosa, Rubina, Okita, Yutaka, Miyairi, Takeshi, Kunihara, Takashi, de Heer, Frederiek, Koolbergen, Dave, Marsman, Mandy, Gökalp, Arjen, Kluin, Jolanda, Bekkers, Jos, Duininck, Liesbeth, Takkenberg, Johanna J.M., Klautz, Robert, Van Brakel, Thomas, Arabkhani, Bardia, Mecozzi, Gianclaudio, Accord, Ryan, Jasinski, Marek, Aminov, Vladislav, Svetkin, Mihail, Kolesar, Adrian, Sabol, František, Toporcer, Tomas, Bibiloni, Ignacio, Rábago, Gregorio, Alvarez-Asiain, Virginia, Melero, Amaia, Sadaba, Rafael, Aramendi, José, Crespo, Alejandro, Porras, Carlos, Evangelista Masip, Arturo, Kelley, Shelagh, Bavaria, Joseph, Milewski, Rita, Moeller, Patrick, Wenger, Isaac, Enriquez-Sarano, Maurice, Alger, Stan, Alger, Aurelie, and Leavitt, Katie

Published
2019
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25. Aortic Valve Surgery in Nonelderly Patients: Insights Gained From AVIATOR

Author

Dinges, Christian, Steindl, Johannes, Ziller, Rosina, Benkacem, Taoufik, Coulon, Corinne, Kaddouri, Fadoua, de Meester, Christophe, Pasquet, Agnès, Nijs, Jan, Van Mossevelde, Veerle, Loeys, Bart, Meuris, Bart, Schepmans, Evi, Van den Bossche, Klaartje, Verbrugghe, Peter, Goossens, Wenke, Gutermann, Herbert, Pettinari, Matteo, Lenoir, Marien, Noly, Pierre-Emmanuel, Tousch, Michael, Shah, Pallav, Boodhwani, Munir, Rudez, Igor, Baric, Davor, Unic, Daniel, Varvodic, Josip, Gjorgijevska, Savica, Vojacek, Jan, Zacek, Pavel, Karalko, Mikita, Hlubocky, Jaroslav, Novotny, Robert, Slautin, Andrey, Soliman, Said, Arnaud-Crozat, Eric, Boignard, Aude, Fayad, Georges, Bouchot, Olivier, Albat, Bernard, Leguerrier, Alain, Doguet, Fabien, Fuzellier, Jean-François, Glock, Yves, Fernandez, Guy, Chatel, Didier, Zeitoun, David Messika, Jouan, Jérôme, Di Centa, Isabelle, Obadia, Jean-François, Leprince, Pascal, Houel, Rémi, Bergoend, Eric, Lopez, Stéphane, Berrebi, Alain, Tubach, Florence, Monin, Jean-Luc, Pousset, Sarah, Mankoubi, Leila, Noghin, Milean, Diakov, Christelle, Czytrom, Daniel, Borger, Michael, Aicher, Diana, Rauch, Svenja, Theisohn, Frank, Ferrero, Paolo, Stoica, Serban, Matuszewski, Maciej, Yiu, Patrick, Bashir, Mohamad, Ceresa, Fabrizio, Patane, Francesco, De Paulis, Ruggero, Chirichilli, Ilaria, Masat, Mauro, Antona, Carlo, Contino, Monica, Mangini, Andrea, Romagnoni, Claudia, Grigioni, Francesco, Rosa, Rubina, Okita, Yutaka, Miyairi, Takeshi, Kunihara, Takashi, Koolbergen, Dave, Bekkers, Jos, Klautz, Robert, Van Brakel, Thomas, Arabkhani, Bardia, Mecozzi, Gianclaudio, Accord, Ryan, Jasinski, Marek, Aminov, Vladislav, Svetkin, Mihail, Kolesar, Adrian, Sabol, František, Toporcer, Tomas, Bibiloni, Ignacio, Rábago, Gregorio, Alvarez-Asiain, Virginia, Melero, Amaia, Sadaba, Rafael, Aramendi, José, Crespo, Alejandro, Porras, Carlos, Masip, Arturo Evangelista, Milewski, Rita, Moeller, Patrick, Wenger, Isaac, Leon, Christine, Marnette, Jean Marc, Doisy, Vincent, Wautot, Fabrice, Bourguignon, Thierry, Cameron, Duke, Chen, Edward, Lansac, Emmanuel, Youssefi, Pouya, de Heer, Frederiek, Bavaria, Joseph, De Kerchove, Laurent, El-Hamamsy, Ismail, Elkhoury, Gebrine, Enriquez-Sarano, Maurice, Jondeau, Laurent de Guillaume, Kluin, Jolanda, Pibarot, Philippe, Schäfers, Hans-Joachim, Vanoverschelde, Jean-Louis, and Takkenberg, Johanna J.M.

Published
2019
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27. An interventional sheep model of severe aortic valve stenosis hemodynamics for the evaluation of alterations in coronary physiology and microvascular function.

Author

Minten, Lennert, Langenaeken, Tom, McCutcheon, Keir, Bennett, Johan, Van Hecke, Manon, Algoet, Michiel, Bézy, Stéphanie, Duchenne, Jürgen, Puvrez, Alexis, Wouters, Laurine, Voigt, Jens-Uwe, Adriaenssens, Tom, Desmet, Walter, Sinnaeve, Peter, Verbrugghe, Peter, Oosterlinck, Wouter, Claus, Piet, Meuris, Bart, and Dubois, Christophe

Abstract

We aimed to develop a large animal model of subcoronary aortic stenosis (AS) to study intracoronary and microcirculatory hemodynamics. A total of three surgical techniques inducing AS were evaluated in 12 sheep. Suturing the leaflets together around a dilator (n = 2) did not result in severe AS. Suturing of a pericardial patch with a variable opening just below the aortic valve (n = 5) created an AS which was poorly tolerated if the aortic valve area (AVA) was too small (0.38-1.02 cm²), but was feasible with an AVA of 1.2 cm². However, standardization of aortic regurgitation (AR) with this technique is difficult. Therefore, we opted for implantation of an undersized AV-bioprosthesis with narrowing sutures on the leaflets (n = 5). Overall, five sheep survived the immediate postoperative period of which three had severe AS (one patch and two bioprostheses). The surviving sheep with severe AS developed left ventricular hypertrophy and signs of increased filling-pressures. Intracoronary assessment of physiological indices in these AS sheep pointed toward the development of functional microvascular dysfunction, with a significant increase in coronary resting flow and hyperemic coronary resistance, resulting in a significantly higher index of microvascular resistance (IMR) and lower myocardial resistance reserve (MRR). Microscopic analysis showed myocardial hypertrophy and signs of fibrosis without evidence of capillary rarefaction. In a large animal model of AS, microvascular changes are characterized by increased resting coronary flow and hyperemic coronary resistance resulting in increased IMR and decreased MRR. These physiological changes can influence the interpretation of regularly used coronary indices. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Bacterial cellulose as a promising material for pulmonary valve prostheses: In vivo study in a sheep model.

Author

Siondalski, Piotr, Kołaczkowska, Magdalena, Bieńkowski, Michał, Pęksa, Rafał, Kowalik, Maciej M., Dawidowska, Kinga, Vandendriessche, Katrien, and Meuris, Bart

Subjects
PULMONARY valve, PROSTHETIC heart valves, CELLULOSE, SHEEP, BIOABSORBABLE implants, PROSTHETICS
Abstract

Objectives: Currently, no consensus exists regarding the most durable prosthesis for pulmonary valve replacement. Bacterial cellulose is a resistant, nonbiodegradable, nonpyrogenic bioimplant with low hemolysis and clotting properties. We hypothesized that bacterial cellulose heart valve prostheses could be an attractive alternative for pulmonary valve replacement. Methods: We conducted a large animal model experiment in three adult sheep. The animals underwent open‐heart surgery and cardiopulmonary bypass for bacterial cellulose conduit implantation in the pulmonary position. The sheep were followed for seven months, and clinical and laboratory parameters were analyzed. Echocardiographic evaluations were performed at 3 and 7 months. After seven months, the sheep were sacrificed and an autopsy was performed. The explanted conduits were radiologically and histopathologically analyzed. Results: All sheep survived the operation, showing good recovery and normal health status; no adverse events were noted during the 7‐month postoperative follow‐up. Interval laboratory findings were normal with no signs of hemolysis or infection. Echocardiographic analysis after 7 months revealed a normal mean pressure gradient with excellent cusp motion and coaptation; a trace of regurgitation was found in two sheep. X‐ray analysis of the explanted conduits revealed no structural defects in the leaflets with minimal calcification. Histological examination showed slight thickening of the conduit by pannus formation. No material failure, no calcification inside the material, and only minor calcification extrinsic to the matrix were observed. Conclusions: This pilot study provides evidence that bacterial cellulose may be suitable for pulmonary valve prostheses and surgical pulmonary artery plasty. Further studies on the high pressure side of the left heart are needed. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Cardiac Microvascular Endothelial Cells in Pressure Overload–Induced Heart Disease

Author

Trenson, Sander, Hermans, Hadewich, Craps, Sander, Pokreisz, Peter, de Zeeuw, Pauline, Van Wauwe, Jore, Gillijns, Hilde, Veltman, Denise, Wei, Fangfei, Caluwé, Ellen, Gijsbers, Rik, Baatsen, Pieter, Staessen, Jan A., Ghesquiere, Bart, Carmeliet, Peter, Rega, Filip, Meuris, Bart, Meyns, Bart, Oosterlinck, Wouter, Duchenne, Jürgen, Goetschalckx, Kaatje, Voigt, Jens-Uwe, Herregods, Marie-Christine, Herijgers, Paul, Luttun, Aernout, and Janssens, Stefan

Published
2021
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33. Durability of bioprosthetic aortic valves in patients under the age of 60 years – rationale and design of the international INDURE registry

Author

Meuris, Bart, Borger, Michael A., Bourguignon, Thierry, Siepe, Matthias, Grabenwöger, Martin, Laufer, Günther, Binder, Konrad, Polvani, Gianluca, Stefano, Pierluigi, Coscioni, Enrico, van Leeuwen, Wouter, Demers, Philippe, Dagenais, Francois, Canovas, Sergio, Theron, Alexis, Langanay, Thierry, Roussel, Jean-Christian, Wendler, Olaf, Mariscalco, Giovanni, Pessotto, Renzo, Botta, Beate, Bramlage, Peter, and de Paulis, Ruggero

Published
2020
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34. Aortic valve replacement in non-elderly: the gap between reality, guidelines and evidence.

Author

Geuens, Lise, Hoof, Lucas Van, Bruaene, Alexander Van De, Rega, Filip, Meuris, Bart, and Verbrugghe, Peter

Subjects
AORTIC valve transplantation, HEART valve prosthesis implantation, SCIENCE education, MECHANICAL hearts, PATIENT preferences
Abstract

Open in new tab Download slide OBJECTIVES There are several treatment options for non-elderly adults (18–60 years) in need of aortic valve replacement (AVR): a mechanical or biological substitute, a homograft, the Ross procedure or nowadays even transcatheter aortic valve replacement. This study evaluated the current opinions and practices of cardiac surgeons and cardiologists concerning AVR strategies in this patient group. METHODS A 43-item online survey was sent out to several scientific organizations, individual cardiac surgeons, cardiologists and residents/fellows worldwide. RESULTS Two hundred twenty-two physicians from 33 different countries answered the survey. The UK (24%), Belgium (23%) and North America (22%) are best represented. A mechanical valve is the most frequently used substitute in non-elderly. With increasing patient age, the popularity of a biological valve increases. Transcatheter aortic valve replacement and the Ross procedure are each used in <10% of this cohort. Only 12% of the cardiac surgeons has experience with the Ross surgery. In 23%, the patient seems not to be involved in the decision on the type of valve substitute. CONCLUSIONS The preferred surgical treatment for non-elderly patients in need of AVR differs widely. To enable a shared decision-making process including patient preferences, there is more need for collaboration between cardiac departments, as well as education and scientific research about patient-centred outcomes of the different AVR techniques. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Durability of bioprosthetic aortic valve replacement in patients under the age of 60 years — 1-year follow-up from the prospective INDURE registry.

Author

Meuris, Bart, Roussel, Jean-Christian, Borger, Michael A, Siepe, Matthias, Stefano, Pierluigi, Laufer, Günther, Langanay, Thierry, Theron, Alexis, Grabenwöger, Martin, Binder, Konrad, Demers, Philippe, Pessotto, Renzo, Leeuwen, Wouter van, Bourguignon, Thierry, Canovas, Sergio, Mariscalco, Giovanni, Coscioni, Enrico, Dagenais, Francois, Wendler, Olaf, and Polvani, Gianluca

Published
2023
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36. Pacemaker after Sutureless and Rapid-Deployment Prostheses: A Progress Report from the SURD-IR.

Author

Pollari, Francesco, Berretta, Paolo, Albertini, Alberto, Carrel, Thierry, Teoh, Kevin, Meuris, Bart, Villa, Emmanuel, Kappert, Utz, Andreas, Martin, Solinas, Marco, Misfeld, Martin, Savini, Carlo, Fiore, Antonio, Shrestha, Malakh, Santarpino, Giuseppe, Martinelli, Gian Luca, Mignosa, Carmelo, Glauber, Mattia, Yan, Tristan, and Fischlein, Theodor

Subjects
AORTIC valve transplantation, AORTIC valve, MITRAL valve, PROSTHETICS, CARDIOPULMONARY bypass, ARTIFICIAL implants, THORACOTOMY
Abstract

Objectives The aim of this study was to investigate the need for postoperative permanent pacemaker implantation (PPI) following sutureless and rapid-deployment aortic valve replacement (SuRD-AVR) in the context of a progress report from a large multicenter international registry (SURD-IR). Methods We retrospectively analyzed 4,166 patients who underwent SuRD-AVR between 2008 and 2019. The primary outcome was the need for PPI before discharge. The study population was analyzed separately according to the implanted prostheses (Su cohort and RD cohort). Each cohort was divided into two groups based on the operation date: an early group ("EG" = 2008–2016) and a late group ("LG" = 2017–2019). Results The rate of PPI decreased significantly in the Su cohort over time (EG = 10.8% vs LG = 6.3%, p < 0.001). In the Su cohort, a decrease in age, risk profile, and incidence of bicuspid aortic valve, increased use of anterior right thoracotomy, reduction of cardiopulmonary bypass time and of associated procedures, and more frequent use of smaller prostheses were observed over time. In the RD cohort, the rate of PPI was stable over time (EG = 8.8% vs LG = 9.3%, p = 0.8). In this cohort, a younger age, lower risk profile, and higher incidence of concomitant septal myectomy were observed over time. Conclusion Our analysis showed a significant decrease in the PPI rate in patients who underwent Su-AVR over time. Patient selection as well as surgical improvements and a more accurate sizing could be correlated with this phenomenon. The RD cohort revealed no significant differences either in patient's characteristics or in PPI rate between the two time periods. [ABSTRACT FROM AUTHOR]

Published
2023
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39. The rise of new technologies for aortic valve stenosis: A comparison of sutureless and transcatheter aortic valve implantation

Author

D'Onofrio, Augusto, Salizzoni, Stefano, Rubino, Antonino S., Besola, Laura, Filippini, Claudia, Alfieri, Ottavio, Colombo, Antonio, Agrifoglio, Marco, Fischlein, Theodor, Rapetto, Filippo, Tarantini, Giuseppe, Dalèn, Magnus, Gabbieri, Davide, Meuris, Bart, Savini, Carlo, Gatti, Giuseppe, Aiello, Marco Luigi, Biancari, Fausto, Livi, Ugolino, Stefàno, Pier Luigi, Cassese, Mauro, Borrello, Bruno, Rinaldi, Mauro, Mignosa, Carmelo, and Gerosa, Gino

Published
2016
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40. The sutureless aortic valve at 1 year: A large multicenter cohort study

Author

Folliguet, Thierry, Zannis, Kostantinos, Pfeiffer, Steffen, Santarpino, Giuseppe, Shrestha, Malakh, Sarikouch, Samir, Gummert, Jan F., Mohr, Friedrich W., Dohmen, Pascal, Stalder, Mario, Roost, Eva, Filipiak, Krzysztof, Niklewski, Tomasz, Roques, Xavier, Flameng, Willem J., Laczkovics, Axel M.M., Bechtel, Matthias, Prat, Alain G., Banfi, Carlo, Dapunt, Otto E., Eichstaedt, Harald C., Harringer, Wolfgang, Carstens-Fitz, Ulrike, Spyt, Tom J., Wimmer-Greinecker, Jan Gerhard, Machner, Matthias, Tan, Erwin S.H., Casselman, Filip P.A., Yilmaz, Alaaddin, Sonker, Uday, Bleiziffer, Sabine, Oberwalder, Peter J., Kocher, Alfred A., Seitelberger, Rainald, Treede, Hendrik, Conradi, Leonard, Cocchieri, Riccardo, De Mol, Bas, Roussel, Jean-Christian, Despins, Philippe, Jakob, Heinz G., Wendt, Daniel, Fischlein, Theodor, Meuris, Bart, Hakim-Meibodi, Kavous, Misfeld, Martin, Carrel, Thierry, Zembala, Marian, Gaggianesi, Sara, Madonna, Francesco, Laborde, François, Asch, Federico, and Haverich, Axel

Published
2016
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42. DOACs in the Anticoagulation of Mechanical Valves: A Systematic Review and Future Perspectives.

Author

Langenaeken, Tom, Vanoppen, Arnaud, Janssens, Fien, Tanghe, Loes, Verbrugghe, Peter, Rega, Filip, and Meuris, Bart

Subjects
PROSTHETIC heart valves, VALVES, ANTICOAGULANTS, HEART valve diseases, ORAL medication
Abstract

Valvular heart disease is a common disease often necessitating valve replacement. Mechanical heart valves (MHVs) are often used in younger patients because of their longer durability. Their main disadvantage is the need for lifelong anticoagulation. Warfarin is considered a standard treatment, but it is far from perfect. Direct oral anticoagulants (DOACs) are a new and more patient-friendly alternative to warfarin when anticoagulation is required, but have not yet been approved for the indication of mechanical valves. Evidence acquisition: A literature search of Pubmed, Embase, Web of Science (Core Collection), and Cochrane Library (from inception to May 2023) was performed using a search string that was well defined and not modified during the study. An extensive overview of the search terms used in each database can be found in the Appendix. Only prospective clinical trials were included in this review. A total of 10 publications were included in this review. Relevance to clinical practice: This systematic review summarizes the different types of DOACs and their possible use in the anticoagulation of mechanical valves. We aim to propose future directions in anticoagulation research for mechanical valves. Conclusions: DOAC use in MHVs has been halted due to the failure of both dabigatran and apixaban in two major clinical trials. However, rivaroxaban was successful in two small clinical trials. Ample research is still needed to explore new valve designs as well as new anticoagulation targets. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Formal consensus study on surgery to replace the aortic valve in adults aged 18–60 years .

Author

Stoica, Serban, Beard, Chloe, Takkenberg, Johanna J. M., Mokhles, Mostafa M., Turner, Mark, Pepper, John, Hopewell-Kelly, Noreen, Benedetto, Umberto, Nashef, Samer A. M., El-Hamamsy, Ismail, Skillington, Peter, Glauber, Mattia, De Paulis, Ruggero, Tseng, Elaine, Meuris, Bart, Sitges, Marta, Delgado, Victoria, Krane, Markus, Kostolny, Martin, and Pufulete, Maria

Subjects
VENTRICULAR ejection fraction, AORTIC valve surgery, AORTIC valve insufficiency, RHEUMATIC heart disease, ORAL medication, ADULTS, HEART valve prosthesis implantation, PROSTHETIC heart valves, TRICUSPID valve diseases
Published
2023
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