121 results on '"Menon, Ramesh"'
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2. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
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Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, 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Basher, AKM K, Mitul, Ashrarur Rahman, Islam, Nazmul, Oosterkamp, Antje E, Ahmed, Tanveer, Hannan, M Jafrul, Padmore, Greg M, Doyle, Alex F, LaCorbiniere, Karisha L, Boyce, Rico D R, Ragoobar, Paul T, Walkes, Keisha M Y, Haynes, Amelia A, Corbin, Sasha M, Litvina, Yauheniya A, Makhmudov, Anvar, Strypstein, Sébastien, Dhondt, Bert, Rasschaert, Ricky, Farid, Yasser, Wahib, El Mahdi, Pigeolet, Manon, Belle, Koen Van, De Wachter, Stefan, Komen, Niels, Vandeputte, Mathieu PJ, Jansen, Yanina JL, Stijns, Jasper, Eynde, Jef Van den, Olowo, Benedicte I, Feraudy, Israel C, Dragisic, Vedran, Martinovic, Vlatka, Barišić, Tatjana, Penava, Nikolina, Hudic, Igor, Delibegovic, Samir, Bogdanović, Gordana, Grgić, Gordana, Cerovac, Anis, Cerovac, Elmedina, Bedada, Alemayehu G, Baiocchi, Glauco, Wainstein, Alberto, Moisés, Elaine Christine D, Zani, Ana Carolina Tagliatti, de Campos Prado, Caio Antonio, Panis, Carolina, Rech, Daniel, Soares da Silva, Ruan Gabriel, Joviliano, Edwaldo E, Rezende, Ricardo F, Reis, Igor G N, Pires, Robinson E S, Christiano, Adriana Borgonovi, Consani, Heitor F X, Pugliesi, Felipe G, Takeda, Flavio R, Mariani, Alessandro W, Valadares, Ricardo J B, Andreollo, Nelson A, Lopes, Luiz Roberto, Tonello, Cristiano, Alonso, Nivaldo, dos Santos, Carlos Ferreira, Lima, Leonardo S, Salgado, Wilson, Pereira, Thiago H S, Gatti, Arthur Paredes, Oliva, Ramon N L, Nardi, Caroline N, Sousa, Alvaro F L, Ribeiro, Ivonizete P, Carvalho, Herica E F, Oliveira, Layze B, Schneider, Guilherme, Casteleins, William Augusto, Silva, Larissa M, Gomes, Carlos Augusto, da Cunha Viana Júnior, Alonço, Cruz, Ricardo P, Gomes, Gustavo MA, Buarque, Igor L, Barros, Aldo V, Marangon, Gustavo B, Flumignan, Ronald LG, Nakano, Luís CU, Pascoal, Patrícia IF, Santos, Brena C, Kuramoto, Danielle AB, Correia, Rebeca M, Amaral, Fabio CF, Flumignan, Carolina DQ, Dussán-Sarria, Jairo A, Simões, Romeo L, Amorim, Robson L, Silva, Jeancarllo S, Lyra Junior, Humberto F, Julio, Nathalia S, Gerber, Marlus T, dos Santos, José Mauro, de Oliveira, Joao Carlos C, Palamim, Camila VC, Marson, Fernando AL, Gomes, Iolanda M, Oliveira, Priscila R, Lima, Ana Lucia L M, Carvalho, Vladimir C, Silva, Jorge S, NA, Ulysses Ribeiro, Laporte, Gustavo Andreazza, Gonçalves, Mateus Capuzzo, Botacin, Lais S, Avelino, Melissa AG, Brito, Luiz Gustavo O, Hristova, Evguenia T, Stoyanov, Vladislav Valentinov, Sakakushev, Boris E, Dardanov, Dragomir D, Sokolov, Manol B, Mehta, Ananya, Gyokova, Elitsa H, Abdullahi, Mohamed, Karamanliev, Martin P, Dimitrov, Dobromir D, Slavchev, Mihail T, Atanasov, Boyko Ch, Yotsov, Tsanko I, Hadzhiev, Dimitar Bozhidarov, Stock, Simon E, Nwegbu, Chukwuemeka Gerald, Tanyi, Tanyi John, Brown, James A, Arneja, Jugpal S, Lee, Susan M, Kancherla, Ramya, Kidane, Biniam, Champagne, Pierre-Olivier, Ma, Xiya, Munro, Allana, McKeen, Dolores M, Glinka, Juan, Vasarhelyi, Edward M, Subramani, Yamini, Alfaro, Hilda, Shah, Ushma J, Gonzalez, Nelson J, MacNeil, S Danielle, Nagappa, Mahesh, Malthaner, Richard A, Brackstone, Muriel, Alkhamesi, Nawar A, Qiabi, Mehdi, Arango-Ferreira, Camila, Prempeh, Agya B A, Dumitra, Sinziana, Spence, Richard T, Bedard, Eric LR, Luc, Jessica GY, Johnston, Brian R, Attabib, Najmedden, Persad, Amit RL, Das, Sunit, Khoshbin, Amir, Ladha, Karim S, Sankar, Ashwin, Teja, Bijan, Daza, Julian F, Chan, Veronica F, Baertschiger, Reto M, Zani, Augusto, Nessim, Carolyn, McIsaac, Daniel I, Singh, Mandeep, Behzadi, Abdollah, Dell, Angela J, Al Riyami, Salim M, Dajani, Khaled Z, Bigam, David, Manikala, Vinod K, Street, John T, Mayson, Kelly V, Wallis, Christopher J D, Mimica, Ximena, Villanueva, Julio, Altamirano, Roberto, Waissbluth, Sofia, Marín, Diego I, Fonseca, Bruno Catoia, Hodali, Andrés J, Ramos, Andrea I, Valenzuela, Marco A, Torres, Janina J, Song, Yi, Yang, Wah, Aldanakh, Abdullah, Alradhi, Mohammed, Lyu, Yidong, Chen, Yan, Fletcher, Angélica V, Camargo, Daniela, Casanova, Rafael Figueroa, Medina, Camilo Andres Caicedo, Bolivar, Dinimo, Garcia, Tatiana Carolina Beltran, Pedraza, Nestor F, Garcia-Lopez, Andrea, Patino-Jaramillo, Nasly G, Giron, Fernando A, Rivera, Carlos J- Perez, Nieto-Calvache, Albaro José, Ariza, Fredy, Orozco-Chamorro, Claudia Milena, Nanez, Maria A, Garces, Diana S, Figueroa, Luis M, Badiel, Marisol, Martinez, Delio F, Coll-Tello, Brenda, Camelo, Hector F, Montoya Casella, Antonio J, Ordoñez, Sebastian, Velez Sanchez, Paola A, Salcedo, Juan C, Villegas, Lina M, Holguín, Jorge A, Cardozo, Jesús Hernán Tovar, Perdomo, Jorman Harvey Tejada, Perdomo, Valentina Gutiérrez, Rivera-Rincon, Natalia A, Gomez, Paula Torres, Delgado-Nieto, Elena Leonor, Isaza-Restrepo, Andres, Vargas, Felipe, Vargas, Ana M, Castro, Arnulfo Andrade, Navarro, Jorge A, Vargas, Saul E, Calvache, Jose A, Mendoza-Arango, Maria C, Bernal, Jorge Luis Vélez, Gonzalez, Felipe O, šantak, Goran, Kirac, Iva, Kršul, Dorian, Versic, Ana Bosak, Augustin, Goran, Kulis, Tomislav, Kastelan, Zeljko, Hadzibegovic, Ana Danic, Grsic, Kresimir, Hudolin, Tvrtko, Tarle, Marko, Mamic, Matija, Lorencin, Mia, Luksic, Ivica, Habek, Dubravko, Konjevoda, Suzana, Mihanovic, Jakov, Antoniou, Stavros A, Almezghwi, Heyam A, Gouvas, Nikolaos, Martinek, Lubomir, Novysedlak, Rene, Žatecký, Jan, Meyhoff, Christian S, Ellebæk, Mark Bremholm, Batista, Sylvia Jeanne, Rodriguez, Julia, Mejia De la Cruz, Dolores, Jimenez, Mirna Giselle Santiago, Dominguez, Carla M, Negrete, José R, Campuzano, Pedro N, Mogrovejo, Daniel L, Armas, Maria J, Arboleda-Bustan, Jenny E, Lincango-Naranjo, Eddy P, El-Kassas, Mohamed, Awad, Ahmed K, Alazab, Emad, Abdulmaseh, Kyrillos G, Diab, Sherein, El Wahab, Mostafa HAbd, Darwesh, Amr, Mostafa, Badr E, Abdelgalil, Mahmoud Shaban, Elbadawy, Merihan A, Reda, Ali M, Asla, Amir Fathi, Fayed, Notaila M, Ahmed, Mohamed S, Elsadek, Menan Ahmed, Gad, Dalia Elsayed, El Saadany, Aya Gameel, Elsadek, Aalaa Mohamed, Sayed, Ahmed E, Naeem, Ahmed, Al-Mallah, Abdullah, Abdelsamed, Ahmed A, Ewedah, Moataz, Soliman, Mohamed O, Tanas, Yousef, Hamouda, Mohammed, Mahfouz, Marina H, Abdo, Manal E, Dean, Yomna E, Lka, Karim, Abodeeb, Aya O, Ashoush, Fouad M F B, Elsherbiny, Roqaia R, Gadelkarim, Mohamed, Osman, Nermin A, MIbrahim, Maya, Youssef, Nehal G, Ibrahim, Mohamed Hamdy, Soliman, Antonios, Gadelkareem, Rabea A, Abbas, Ahmed M, Mohamed Hussein, Aliae AR, Abdelsattar, Khaled, Maher, Ahmed, Elabd, Mohamed M, Abdelazim, Hassan, Ibraheem, Maher H, Noureldin, Yasser A, Elfiky, Mahmoud, Ebrahim, Mohamed A, Abdelrahman, Ahmed Saber Mohamed, Marei, Mahmoud Marei, Elkhalawy, Aya M, Azzam, Ahmed Y, Azab, Mohammed A, Elmasry, Ahmed H, Elgazar, Amr, Shalaby, Mahmoud Mohamed Mohamed, Mahmoud, Mohammad S, Qassem, Mohamed G, Kinani, Hussein, Wahba, Abdelrahman M, Ezzat, Rana Hisham, Ahmed, Mai H, Elshawy, Mohamed Elemam, Faragalla, Hazem Metwally, Mahmoud, Khalid D, Nafea, Ahmed M, Abdel-Maboud, Mohamed, Abozied, Hesham, Moharam, Modather, Shehata, Ashraf H, ElKafrawy, Samir A, Tayiawi, Mosaab M, Elghadban, Hosam M, Emara, Moataz M, Shehta, Ahmed, Saqr, Amira M, Abdelelsalm, Wafaa M, Elshennawy, Eslam M, Radwan, Samar T, Awad, Selmy S, Emile, Sameh H, Aldosoky, Wesam A, Elfeki, Hossam, Gendi, Sara N, Abdelsalam, Hala Adel, Hammad, Mohammed, Shalaby, Mostafa, Sakr, Ahmad Hammad, Abdelmaksoud, Mohamed A, Alawady, Mohammed, Omran, Abdelrahman Azzam, Allam, Abdallah R, Ismail, Zainab, Gaballah, Khaled M, AlGady, Mahmoud Fathy Mahmoud, Raslan, Ahmed M, Gharbia, Khaled, Nuser, Abdelazez A, Sayed, Ahmed Kamal, Elshahawy, Mahmoud A, Ghaly, Galal, Sherif, Ahmed Elshawadfy, Makram, Abdelrahman M, Makram, Omar M, Ahmed, Ola, Helmy, AbdelRahman M A, Abdelwahab, Khaled M, Abdelkhalek, Mohamed, Metwally, Islam H, Shetiwy, Mosab Saad, Zuhdy, Mohammad, Ramadan, Salma I, Abdelghany, Mohamed, Omar, Mohammed A, Soliman, Ziad A, Ali, Hossam T, Elnoamany, Salma, Ghozy, Sherief, Abbas, Alzhraa S, Shehata, Mostafa A, Mahmoud, Sahar A, Elsaman, Mohammed A, Fayad, Elsayed A, Radwan, Asmaa, El-Sakka, Ahmed I, Sallam, Asser, Elbahnasawy, Mohamed G, Esmail, Eslam S, Hawila, Ahmed Maher, Hamada, Mohamed K, Motawea, Sara H, Morsy, Mohamed S, El-Sheemy, Hatem Refaat, Ebada, Mahmoud Ahmed, Khedr, Ali H, Gad, Ahmed, Elmandouh, Omar, Elmandouh, Reem, Alkanj, Souad, Youssef, Mohammad G, Awad, Kamal, Mohammed, Maged, Elsayad, Ahmed H, Rätsep, Tõnu, Wolle, Melatework A, Negussie, Abraham G, Adimass, Misganaw A, Misganaw, Bereket Tsegaye, Bezabih, Yoseph S, Assefa, Biniam Zemedu, Shumye, Getachew W, Mengesha, Mengistu G, Gechera, Dagnachew Y, Mohammed, Adnan A, Mulugeta, Gersam A, Metaferia, Yonas Y, Kifetew, Ashebir B, Degefa, Eyueal A, Deressa, Yadani M, Gonfa, Kebebe Bekele, Bedane, Zewdie G, Ayalew, Alem M, Ayele, Henok Teshome, Abebe, Engida, Worku, Bereket Atnafu, Sisay, Million M, Kassa, Dawit Worku, Awedew, Atalel F, Bayable, Abera C, Tiruneh, Abraham Genetu, Hailu, Samuel, Numaro, Yilkal T, Ademe, Yonas, Baleh, Abat S, Megerssa, Thomas B, Kejela, Segni, Derilo, Habtamu T, Akililu, Yemisirach B, Lebbe, Iris, Sarjanoja, Elise K, Kauppila, Joonas H, Sinikumpu, Juha-Jaakko, Giordano, Salvatore, Kantor, Elie, Soussan, Romy, Tommaso, Cipolat Mis, Nappi, Francesco, Morichau-Beauchant, Tristan, Nahum, Julien, Maillet, Jean-Michel, Godement, Mathieu, Jouffret, Lionel, Migliorelli, Federico, De Simone, Belinda, Brunaud, Laurent, Fuchs-Buder, Thomas, Testelin, Sylvie, Bin, Kim, Boucher, Sophie, Schmitt, Françoise, Lakkis, Zaher, Harper, Luke, Slim, K, Piessen, Guilaume, Eveno, Clarisse, Ballouhey, Quentin, Taibi, Abdelkader, Crenn, Vincent, Duchalais, Emilie, Azzis, Olivier, Tuech, Jean-Jacques, Vaysse, Charlotte, Weyl, Ariane, Vergriete, Kelig, Charbonneau, Helene, Ezanno, Anne-Cecile, Malgras, Brice, Basso, Celeste Del, Duquesne, Igor, Bernabei, Federico, Rothschild, Pierre-Raphaël, Abbo, Olivier, Manceau, Gilles, Chamouni, Alexandre, Crétolle, Célia, Arnalsteen, Laurent, Mikhael, Elie, Police, Andrea, Montero-Macias, Rosa, Villefranque, Vincent, Maisonneuve, Emeline, Langlais, Tristan, Seeliger, Barbara, Pessaux, Patrick, Gonzalez, Cristians A, D'Urso, Antonio, Angeles, Martina A, Seguin-Givelet, Agathe, Des Deserts, Marc Danguy, Gaujoux, Sebastien, de Ponthaud, Charles, Chartier-Kastler, Emmanuel J, Ali, Liza, Peycelon, Matthieu, Mege, Diane, Demetrashvili, Zaza, Stoleriu, Mircea G, Keppler, Lena, Saier, Tim, Konrads, Christian, Tapking, Christian, Kamphues, Carsten, Bulian, Dirk R, Schmedding, Andrea, Doerner, Johannes, Gut, Anna E, Rolinger, Jens, Kirschniak, Andreas, Schröder, Lars, Reim, Daniel, Safi, Seyer, Fichter, Andreas M, Wagner, Arthur, Meyer, Bernhard, Gempt, Jens, Sablotzki, Armin R, Herzberg, Jonas, Altenburg, Manuel, Yenilmez, Ferhat, Meins, Jan, Aghwan, Louai A, Börner, Nikolaus, Keppler, Alexander M, Seyfried, Steffen, Rassweiler-Seyfried, Marie-Claire, Kriegmair, Maximilian, Kowalewski, Karl-Friedrich, Gousias, Konstantinos, Strotmann, Johanna J, Höhn, Philipp, Horn, Julian, Knipschild, Julia M, Siemen, Leonie, Luu, Andreas Minh, Horch, Raymund E, McLean, Aaron Lawson, Lindert, Judith Anne Teresa, Ziemann, Sebastian, Modabber, Ali, Winnand, Philipp, Hölzle, Frank, Sommer, Björn, Wolf, Sebastian, Shiban, Ehab, Recker, Florian, Güresir, Erdem, Randau, Thomas M, Güresir, Agi, Velten, Markus, Vilz, Tim O, Wittmann, Maria, Willis, Maria A, Glowka, Tim R, Bork, Ulrich, Hecker, Matthias, Hecker, Andreas, Reichert, Martin, Miller, Clemens, Nemeth, Marcus, Ronellenfitsch, Ulrich, Kleeff, Jorg, Lorenz, Kerstin, Kisser, Ulrich, Schneider, Rick, Seiwerth, Ingmar, Osterhoff, Georg, Linz, Valerie C, Mallmann, Michael R, Rokohl, Alexander C, Heindl, Ludwig M, Wawer Matos, Philomena A, Cursiefen, Claus, Mallmann, Christoph A, Domroese, Christian M, Königsrainer, Alfred, Yurttas, Can, Thiel, Karolin, Vahl, Julius M, Wiegering, Armin, Lock, Johan F, Heuer, Annika, Reiter, Alonja, Stangenberg, Martin, Böttcher, Arne, Kaemmerer, Daniel, Mensah, Kofi T, Gyamfi, Frank E, Opandoh, Isabella N M, Ofori, Emmanauel O, Baidoo, Ebikela I, Baidoo, Richard O, Azize, Diallo A, Appiah-Thompson, Peter, Agbeno, Evans K, Ken-Amoah, Sebastian, Rahman, Ganiyu A, Kpangkpari, Richard, Aniakwo, Luke A, Nortey, Michael, Agyapong, Meshach M, Boakye, Benedict, Mensah, Philip, Agyen-Mensah, Kwasi, Amoako-Boateng, Mabel P, Mensah, Samuel, Debrah, Sam, Yakubu, Mustapha, Adam-Zakariah, Leslie Issa, Davor, Anthony, Arthur, Joshua, Dzogbefia, Mawutor, Konney, Anna, Konney, Thomas O, Amoah, Michael, Barnor, Isaac, Issahalq, Mohammed Duah, Hoyte- Williams, Paa Ekow, Awortwi, Wilfred Sam, Hammond, Bernard, Awoonor-Williams, Ronald, Naabo, Nuhu N H, Appiah-Kubi, Adu, Adanu, Kekeli Kodjo, Clegg-Lamptey, Joe Nat A, Adae, Jefferson Owusu, Adjeso, Theophilus T K, Yahaya, Mundashiru, Ansah-Agyei, David A, Charadan, Ana Maria Simono, Labrada, Magdiel Rodriguez, Issaka, Adamu, Yabasin, Iddrisu B, Antwi, David A, Manan, Lukman, Bukari, Mohammed I S, Buunaaim, Alexis D B, Alatiiga, John Abanga, Sheriff, Mohammed, Kumi, Emmanuel O, Bonsaana, Gilbert B, Micha, Georgia, Kiriakopoulos, 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U, Çakici, Mehmet Çağlar, Iplikci, Ayberk, Yildirim, Asif, Ozgur, Ilker, Sen, Comert, Dincer, Muserref B, Erginöz, Ergin, Sanli, Ahmet Necati, Turna, Akif, Askar, Ahmet, Uludağ, Server Sezgin, Guldogan, Cem E, Ozmen, Mehmet M, Bozkurt, Mehmet A, özcan, Adem, Kara, Yasin, Kocataş, Ali, Guner, Ali, Sari, Ramazan, Memisoglu, Ecem, Saracoglu, Kemal T, Tosun, Yasin, Çetin, Kenan, Kalafat, Erkan, Taskiran, Cagatay, Vatansever, Dogan, Giray, Burak, Tatar, Ozan C, Köksal, Hande, Özkent, Mehmet Serkan, Ulutaş, Mehmet E, Hamarat, Mustafa B, Coskun, Bora, Abbasov, Aykhan, Altinsoy, Ezgi, Uprak, Tevfik Kivilcim, Saracoglu, Ayten, Ugurlu, M Umit, Kose, Emin, Ozgen, Utku, Sungurtekin, Ugur, Gonullu, Emre, Bayhan, Zulfu, Akin, Emrah, Mantoglu, Baris, Colak, Elif, Kucuk, Gultekin Ozan, Yuksel, Cemil, Aydin, Ferit, Dogan, Lutfi, Culcu, Serdar, Tufan, Aydin Eray, Citgez, Bulent, Akpinar, Göksever, Köksoy, Ülkü C, Ulgur, Hanife Seyda, Kalin, Murat, Ozkan, Omer Faruk, Yildirak, Muhammed Kadir, Atici, Semra Demirli, Salimoğlu, Semra, Abud, Burcin, Calik, Bulent, Kamer, Erdinc, Kebabci, Eyup, Uylas, Ufuk, Teker, Kenan, Cakmak, Guldeniz Karadeniz, Gultekin, Fatma Ayca, Xaviour, Okedi Francis, Isaac, Otolia, Gaston, Turinawe, Asiimwe, Daniel, Vahwere, Bienfait Mumbere, Sikakulya, Franck Katembo, Lule, Herman, Lugobe, Henry Mark, Lekuya, Hervé Monka, Namugenyi, Christine, Kiweewa, Ronald, Bosco, Muhangi, Yovenko, Ihor, Kopetskyi, Viacheslav, Maksymenko, Bogdan, Khan, Sabina A, Padvi, Amit Vasantrao, Serour, Mohamed A, Beigh, Shamim Ahmad, Elsayed, Hisham M, Mohamed, Awadelkarim O, Basappanavar, Vikram Somashekhar, Al-Wandi, Amna S, Khalil, Kareem S, Younis, Muhammad Umar, Al Saadi, Hayder S Abdulhadi, Heidan, Ginan K, Trehan, Ravi K, Davies, Justin, Ashcroft, James, Georgiades, Fanourios, Durrani, Amer J, Price, Stephen J, Wong, Kai Yuen, Agrawal, Amit, Seah, Matthew KT, Saad, Marwa M E, Segaren, Nicholas, Ghobrial, Marios, Balakrishnan, Anita, Forouhi, Parto, Khan, Wasim S, Wheeler, James, Schache, Andrew G, Katsikostas, Dimitrios P, Angelou, Dimitrios, Fell, Adam J, Madani, Rana, Dindyal, Shiva, Seraj, Shaikh S, Sharavanan, Premalatha, Iqbal, Muhammad R, Wong, Nicholas J, Lo, William B, Soon, Wai C, Hammouche, Dalia, Lee, Jonathan DE, Pachl, Max J, Alexander, Dinesh, Ahmad, Shoaib, Morley, Hannah L, Selwyn, David, Wareing, Jonathan, Oktseloglou, Vlasios, Bobak, Peter, Rampersad, Lisa S, Mohamed, Mazin, Kaur, Mandeep, Athanasiou, Antonios, Martin, Benjamin P, Jichi, Tarik S, Batchelor, Tim JP, Rozwadowski, Sophie, Maniarasu, Sarveen, Seyed-Safi, Parisah K, Kutuzov, Vladislav, Shah, Hemina B, Noton, Toby M, Dela Cruz, Nina Jyne Minette, Trehan, Neev, Tokidis, Evripidis, Byrne, Matthew H V, Winter, Stuart C, Pinto-Lopes, Rui, Pavithran, Aswathy, Khalifa, Ahmad O, Eardley, Nicola J, Ashour, Rami, Steinke, Jacqueline D, Esmail, Husayn D, Bence, Matthew N, Walters, Samuel T, Akinyemi, Tosin O, Lakpriya, Sathya, Moawad, Nader N, Panahi, Pedram, Lau, Joshua, McAleer, Stephen, Laoye, Adeyinka, Hussain, Abdulzahra Abdulsamad, Zafar, Muneeb, Elsheikh, Mohammed H, Shaerf, Daniel A, Soggiu, Fiammetta, Massoumi, Abaris, Gareb, Fahed, Yao, Mark W, Qamar, Mubasher A, Fang, Clarissa E H, Greenhalgh, Michael S, Hunt, Alexander, Oladeji, Emmanuel O, Benjamin, Miles W, Beak, Philip, Rae, Fraser J, Aithie, Joanna M S, Clarke, Gareth W J, Veeramootoo, Darmarajah, Ashman, Alex J, Kahka, Ehab E, Rafe, Tanvir, PATEL, PANNA K, Albirnawi, Hatim, Katory, Mark, Fisher, Ann, Amonkar, Sunil J, Rao, Pawan Kumar Dhruva, Holroyd, David J, Gkikas, Andreas, Newton, Lydia S, Kirk, Alan J B, Khalid, Ayesha, Ferguson, David, Stanier, Paul B, Shah, Vinay, El-Boghdadly, Kariem, Schizas, Alexis M P, ilyas, Minahi, George, Mark L, Gawad, Mothana, Groom, William D, Al-Azzawi, Mohammed, Ahluwalia, Julian CJ, Punjabi, Prakash P, Cheung, Fang Yi, Wilson, Michael D, Mitrofan, Claudia Gabriela, Malam, Yogeshkumar, Townson, Adam, Loubani, Mahmoud, Yau, Jih Dar, Seebah, Kevin, Akowuah, Enoch F, Pushpoth, Sreekumari R, Viswanath, Yirupaiahgari KS, ElSanhoury, Kareem, Chew, Misha, Walker, Thomas E, Elhassan, Almutasim Billah Elbagir, Belcher, Elizabeth, Goricar, Matej, majd, Hooman Soleymani, Knight, Dominic, Ismail, Lamiese, McKinnon, Chris, Ganau, Mario, Prokopenko, Max, Doshi, Neel S, Gkorila, Aikaterina, Sheikh, Nomaan A, Helm, Jessica R, Low, Mei Ken, Ogunfusika, Oluseyi Harold, Bisheet, George, Alhammali, Tariq, Arnob, Ahmed Showki, Singh, Jatinder, Allde, Emma L, Sambhwani, Sharan H, Dube, Manas, Gemmill, Elizabeth H, John, Joby, Gerogiannis, Ioannis N, Abuelgasim, Mona A A, Crate, Georgina, Holme, Thomas J, Nguyen, Anh T V, Ho, Michael W, Wade, Ryckie G, Hussain, Azar, Andrzejowski, Paul, Omakobia, Eugene, Eltayeb, Momin, Galabov, Tsanko P, Lee, Chung Yan Vernon, Nazir, Anum, Siaw, Oliver L, Ashford, Robert U, Boddy, Alex P, Ashmore, Christopher D, Shah, Snehadhar M, Gowers, Benjamin T V, Thekkinkattil, Dinesh K, Worku, Dawit, Harky, Amer, Talwar, Rishi, Sagoo, Harkiran K, Jambulingam, Periyathambi S, Smart, Christopher J, Doherty, Daniel T, Mastoridis, Sotiris, Kumar, Sidharth, Mahmoud, Rana, Solari, Francesca, Egan, Richard J, Barry, Jonathan D, Morrison, Jo, Davoudi, Kaveh, Hollyman, Marianne, Kelly, Andrew, Badenoch, Thomas F, pandanaboyana, sanjay, Critchley, Rebecca J, Sarodaya, Varun R, Sinnerton, Robert J H, Manickavasagam, Jaiganesh, Lindsay, Elizabeth F, Arora, Ankita, Hasan, Raashad, Liew, Ignatius, Ozua, Joshua, Kouritas, Vasileios, Collins, Rachael V, Lafford, George H, Moret, Charlie, Chean, Chung Shen, Horgan, Liam F, Aujayeb, Avinash, Siddique, Muhammad Harris, Navaratne, Lalin, Kotecha, Sanjeev, Bellato, Vittoria, Lewis, Sophia E, Ali, Muhammad Usman, Marson, Ben A, Craxford, Simon, Gajjar, Ketankumar, Theophilidou, Elena, Aboelmagd, Tariq, Khatkar, Harman, Awadallah, Mahmoud A, Blanco, Jose A, Chituku, Tsitsi G, Dixon, Oliver GB, sarveswaran, Janahan, Jones, Imogen S, Hammouche, Salah, Vijay, Vardhini, Ooi, Rucira, Karmarkar, Rahi, Khaleeq, Tahir, Bhatia, Mohit, Al-Khazaali, Badr L, Daadipour, Audrina, Mattar, Ahmed, Singhal, Tarun, Mahmoud, Moustafa Ibrahim, Glasbey, James, Nankivell, Paul C, Kalkat, Maninder S, Nour, Shahd, Beggs, Andrew D, Yershov, Danylo Y, Chughtai, Shafiq Ahmad, Youssef, Hesham, Norrish, Alan R, Mohammed, Mohammed M, Gwozdz, Adam M, Charalambous, Michalis P, Knight, Stephen R, McCaul, James A, Bridgman, Elsie A, El Sheikh, Mustafa, Ogunbowale, Akinsola, Wright, Evan O, Ahmed, Usama, Younus, Hafsa, Tincknell, Laura G, Weixing-Ho, Ken, Demetriou, Charis, Hussei, Mohammed, Reilly, John-Joe, Hormis, Anil P, Moug, Susan J, Anazor, Fitzgerald C, Horwell, Edward A, Neal-Smith, Gregory, McNamara, John M, Baryeh, Kwaku W, Bhatti, Khalid M, McKay, Joseph E, Cannoletta, Maria G, Perkins, Clare J, Gopalswamy, Sivakumar, Sheldon, Anna F, John, Joseph B, Mantle, Mark, Toia, Bogdan, Phillips, Andrew J, Al-Khyatt, Waleed, Lund, Jonathan N, Ammar, Ahmed Y, Yim, Guang H, Huntley, Daniel A, Daniels, Ian R, Valverde, Joao, Lumley, Edward David John, Walton, Thomas J, Raptis, Dimitri A, Dimitrokallis, Nikolaos, Nathan, Arjun, Motallebzadeh, Reza, Chowdhury, Shihab, Ahmed, Rezwan F A, Mirnezami, Reza, Szakmany, Tamas, Knight, Dominic J, Al-Azzani, Waheeb, Davies, Huw R, Ooi, Setthasorn Zhi Yang, Oo, Khaing K, Cullis, Paul S, Peng, Ed, Demetriades, Andreas K, Tambyraja, Andrew L, Poon, Michael TC, Brennan, Paul M, Oikonomou, Dimitrios, Newman, Samuel E, Le Blevec, Louise, Otify, Mohamed, Szatmary, Peter, Devkaran, Bhavesh, Sochorova, Dana, Sohrabi, Catrin, Sivaprakasam, Rajesh, Goh, Mingzheng Aaron, Atkinson, Kate V, Soares, Delvene, Prce, Daniela, Cann, Johnathon P, Grobbelaar, Amy C, Bradley, Rebecca, Strauss, Helen J, Taha, Ahmed, Minicozzi, Annamaria, Thakur, Bhaskar, Hanoun, Abdullah, Goru, Poornanand, Baumber, Rachel M, Sobti, Anshul S, Cross, George WV, Havenhand, Tom, Antoniou, George A, Chauhan, Govind Singh, Vokshi, Ismail, Mahmud, Ayesha, Albanese, Erminia, Evans, Daisy, Madhuri, Thumuluru Kavitha, Horsnell, Jonathan D, Zalmay, Pardis, Davies, Angharad J, Aljanadi, Firas, Jeganathan, Reubendra, Jones, Mark, Kakos, Christos, vidya, Raghavan, El-Ghobashy, Alaa, Habib, Ahmed M, Reid, Jeremy P, Rajgor, Harshadkumar Dhirajlal, Ahmed, Omar, Branagan, Graham, Mohamedahmed, Ali Yasen Y, Al-Sabbagh, Ali, Chetty, Govind, Kelty, Clive J, EL-Wajeh, Yasin A M, Tomlinson, James E, Rominiyi, Ola, Sinha, Saurabh, Saad, Sanad, Sahu, Banchhita, Charalampakis, Vasileios, Enemosah, Ibrahim, Williams, Simon J, Yaqoob, Hassan N, Laurent, Edward P, Moreau, Joshua L, Frostick, Rhiannon, Parwaiz, Hammad, Aboelmagd, Karim, Pournaras, Dimitri J, Hristova, Kalina H, Iyengar, Karthikeyan P, Mohamed, Muyed, Artioukh, Dmitri Y, Anwar, Sibtain, Hussein, Mostafa K A, Omogbehin, Tomisin S, Herron, Jonathan B T, Labib, Amir, Patel, Preemal, Marsden, Samuel C, Mehdian, Roshana, Santhirakumaran, Gowthanan, Smelt, Jeremy, Agarwal, Ketan, Lancerotto, Luca, Sahnan, Kapil, Shalhoub, Joseph, Donnelly, Liam J, Erridge, Simon, Chidambaram, Swathikan, Luo, Xun, Bansal, Sujesh, Ryan, Neil AJ, Smith, Alexander C D, Flatman, Michael, Wafaie, Imad, Malik, Muhammad Isfandyar Khan, Thumbadoo, Ruben P, Hussain, Shoaib F, Henein, Christin, Hamad, Yousif T, Belgaumkar, Ajay P, Bosanquet, David C, Kolias, Angelos G, Choi, David, Marcus, Hani J, Horsfall, Hugo RM Layard, Khan, Danyal Z, Sahni, Arun, Millward, Christopher P, Render, Luke, Truss, Adam, Elmoslemany, Tarek, Parmar, Chetan, Hanger, Joseph, Sheen, Jonathon, Rait, Jaideep S, Foreman, Jennifer, Marzouqa, Natalie, Fontalis, Andreas, Voulalas, Grigorios, CHEONG, Ryan Chin Taw, Dindyal, Sanjay, Arumugam, Sathyaseelan, Ward, Thomas R W, Stephens, Alastair S, Douka, Eleftheria, Abou-Foul, Ahmad K, McKay, Siobhan C, Kitchen, Mark O, Rees-Stoner, Oliver DJ, Balasubramanya, Supriya, Akhtar, Muhammad Adeel, Warwick, Andrew J, Pawar, Shweta, Dubey, Vivek, Al-Yaseen, Mustafa W, Williams, Christopher YK, Laird, Alexander, Krishna, Kandaswamy, Anyaugo, Ngozi S, Wuraola, Obafemi K, Odejinmi, Funlayo, Craven, Joanna M, West, Charlotte L, Barter, Reece A, Navaratnam, Devaraj M, Malik, Shahbaz S, Mahendran, Vimaladhithan, Zilvetti, Miguel, Lovegrove, Richard E, Board, Tim N, Zeiton, Moez, Sarwar, Safdar A, Duff, Sarah E, Hsabo, Elmuiz A, Nugur, Ashwani Kumar, Morris, Richard M, Lala, Anil K, Kwan-Feinberg, Rita O, Ross, Samuel W, Dressler, Jeremy A, Evans, Faye M, Wason, Shaun E L, Vogel, Keianna R, Wang, Joanna C, Sulciner, Megan L, Hirji, Sameer, Raoof, Mustafa, Wolff, Christopher J, kent, Ilan, Turan, Alparslan, Teixeira, Pedro G, Olson, Kristofor A, Patel, Neil D, Krishnamoorthy, Vijay, Moris, Dimitrios, Rice, Henry E, Gabr, Hesham, Satoskar, Savni R, Castater, Christine A, Jmaileh, Manal, Payne, Rachel E, Kwon, David S, Aarabi, Shahram, Escobar, Pedro F, Kronenfeld, Joshua P, Dalton, Michael K, Etchill, Eric W, Haut, Elliott R, Vervoort, Dominique, Dehal, Ahmed, McKenney, Mark, Elkbuli, Adel, Gosain, Ankush, Abdelsattar, Zaid M, Naunheim, Matthew R, Burks, Ciersten A, Zhou, Allen S, Heng, Marilyn, Abohashem, Shady, Lozano-Calderón, Santiago A, Reisenauer, Janani S, Mouawad, Nicolas J, Diehl, Thomas M, Eriksson, Evert A, Marwaha, Jayson S, Schroeppel, Thomas J, LaRocca, Christopher J, Chang, Grace H, Hassan, Romana, Nosanov, Lauren B, Rickard, Jennifer L, Avraham, Jacob B, Petrone, Patrizio, Sferra, Joseph J, Hadaya, Joseph, Mead, Brittany S, Hauptman, Jason S, Ahmad, Maleeha, Meola, Antonio, Chang, Steven D, Ko, Ara, Specht, Katherine E, Choudhry, Asad, Encalada, Ronald Zerna, Poggio, Juan L, Xing, Hang, Glass, Nina E, Hooker, Robert, Martins, Paulo N, Scott, Erin M, Bankhead, Brittany K, Giorgakis, Emmanouil, Nigh, Joe, Osborn, Tamara, Tay Lasso, Erika L, Beswick, Daniel M, Berndtson, Allison E, Kaups, Krista L, Chen, Lee-lynn, Farrell, Michael S, Boeck, Marissa A, Vaysburg, Dennis M, Kassam, Al-Faraaz, Turner, Kevin M, Dyas, Adam R, Coleman, Julia R, Folsom, Megan, Lam, Christopher M, Kumer, Sean C, Larson, Kelsey, Turner, Scott, Guidry, Christopher, Reddy, Madhuri, Berbel, German, Findley, Austin, Beahm, David, Bur, Andres, Marlor, Derek, Houndschell, Corey, Carver, Shea, Ulrich, Alissa, Bhutiani, Neal, DiChiacchio, Laura, Abdou, Hossam, Napolitano, Lena M, Ghebre, Rahel, Bass, Gary Alan, Kaplan, Lewis J, Martin, Niels D, Duffy, Caoimhe C, Abdelhamid, Sultan S, Daley, Brian J, Roland, Christina L, Dumas, Ryan P, Ban, Vin Shen, Rajesh, Aashish, Davies, Mark G, Purudappa, Prabhudev P, Walters, Camila B, Lin, Nicole, Ruzgar, Nensi M, Ullrich, Sarah J, Trostchansky, Ivan, Bonilla-Cal, Fernando, Castedo, Fabiola, Sobrero, Helena, Acuña, Gastón, Álvarez, Sofía M, Tarigo, Josefina, Carbajal, Ana C, Carbajal, Ana, Reyes, Antonio R, Al-Eryani, Fatima A, Alqousi, Nardeen N, Alattas, Zainab, Al-Saban, Rafat A, Al-Shehari, Mohammed M, ALHammadi, Nawal T, Shream, Sarah A, Al-Naggar, Hamza M, Al-Qalisi, Lina M, Nadeesh, Areej E, Al-Samawi, Hytham H, Bajjah, Hadeel M, AL-Ameri, Saba A, Albably, Jamal F, Ghannam, Rana A, Shamsan, Amatallah H, Meead, Abdullah A, Al- Zubaidi, Riham Q, Zulait, Mohammed A, Najeeb, Halah, Alsayadi, Musaed M, Al-Mashreqi, Seham K, Al-Jomai, Najla A, Alsayadi, Ramzi A, Al-Naggar, Moath M, Almarashi, Hassan A, Musaeed, Hasna M, Al-Raimi, Ibrahim M, Ghanem, Hossam N, Al-Zazay, Karim A, AL-Mahdi, Shehab A, Almontaser, Amatalaleem S, Savopoulos, Vanessa A S, Munthali, James, Kabongo, Kizito M C, Mushiwokufa, Willard, Ngulube, Allan, Ntoto, Crispin, Magama, Praise T, Dzinotyiwei, Daniel, Chivanga, Shelton K, Dube, Ngqabutho S, Sanchez, Ernesto C, Moyo, Assel T, Chengahomwe, Antony, Chinyowa, Simbarashe, Siamuchembu, Maphios, Bondera, Tafadzwa, and Mushawarima, Trust
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- 2022
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3. Inferring Multiple Sclerosis Stages from the Blood Transcriptome via Machine Learning
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Acquaviva, Massimo, Menon, Ramesh, Di Dario, Marco, Dalla Costa, Gloria, Romeo, Marzia, Sangalli, Francesca, Colombo, Bruno, Moiola, Lucia, Martinelli, Vittorio, Comi, Giancarlo, and Farina, Cinthia
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- 2020
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4. Phenotypic expression and clinical outcomes in a South Asian PRKAG2 cardiomyopathy cohort
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Ahamed, Hisham, Balegadde, Aniketh Vijay, Menon, Shilpa, Menon, Ramesh, Ramachandran, Aishwarya, Mathew, Navin, Natarajan, K. U., Nair, Indu Ramachandran, Kannan, Rajesh, Shankar, Meghna, Mathew, Oommen K., Nguyen, Thong T., Gupta, Ravi, Stawiski, Eric W., Ramprasad, V. L., Seshagiri, Somasekar, and Phalke, Sameer
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- 2020
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5. The Genetic Drivers of Juvenile, Young, and Early‐Onset Parkinson's Disease in India.
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Andrews, Shan V., Kukkle, Prashanth L., Menon, Ramesh, Geetha, Thenral S., Goyal, Vinay, Kandadai, Rukmini Mridula, Kumar, Hrishikesh, Borgohain, Rupam, Mukherjee, Adreesh, Wadia, Pettarusp M., Yadav, Ravi, Desai, Soaham, Kumar, Niraj, Joshi, Deepika, Murugan, Sakthivel, Biswas, Atanu, Pal, Pramod K., Oliver, Merina, Nair, Sandhya, and Kayalvizhi, Anbu
- Abstract
Background: Recent studies have advanced our understanding of the genetic drivers of Parkinson's disease (PD). Rare variants in more than 20 genes are considered causal for PD, and the latest PD genome‐wide association study (GWAS) identified 90 independent risk loci. However, there remains a gap in our understanding of PD genetics outside of the European populations in which the vast majority of these studies were focused. Objective: The aim was to identify genetic risk factors for PD in a South Asian population. Methods: A total of 674 PD subjects predominantly with age of onset (AoO) ≤50 years (encompassing juvenile, young, or early‐onset PD) were recruited from 10 specialty movement disorder centers across India over a 2‐year period; 1376 control subjects were selected from the reference population GenomeAsia, Phase 2. We performed various case‐only and case–control genetic analyses for PD diagnosis and AoO. Results: A genome‐wide significant signal for PD diagnosis was identified in the SNCA region, strongly colocalizing with SNCA region signal from European PD GWAS. PD cases with pathogenic mutations in PD genes exhibited, on average, lower PD polygenic risk scores than PD cases lacking any PD gene mutations. Gene burden studies of rare, predicted deleterious variants identified BSN, encoding the presynaptic protein Bassoon that has been previously associated with neurodegenerative disease. Conclusions: This study constitutes the largest genetic investigation of PD in a South Asian population to date. Future work should seek to expand sample numbers in this population to enable improved statistical power to detect PD genes in this understudied group. © 2023 Denali Therapeutics and The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Should Schools Reopen Early or Late? – Transmission Dynamics of COVID-19 in Children
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Kuttiatt, Vijesh S, Menon, Ramesh P, Abraham, Philip Raj, and Sharma, Shilpa
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- 2020
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7. Rearrangement of N-phosphinoyl-O-sulphonylhydroxylamines and alpha-bromomethylphosphonamidates : a stereochemical study
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Sreedharan-Menon, Ramesh
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540 - Abstract
Part 1 The diastereoisomerically enriched N-phosphinoy1-0-sulphon-ylhydroxylamines PhCHMeP(O)(Ph)NHOX [X = methanesulphonyl (Ms) or p-nitrobenzenesulphonyl (Ns)] react with MeNH2 and ButNH2 (neat, 1.0 M, and 0.1 M in CH2C12) to give the expected diamide rearrangement products PhCHMeP(O)(NHPh)NHR (R = Me or But). The rearrangement proceeded with high stereospecificity for all concentrations of MeNH2 and for neat ButNH2. Single crystal X-ray analysis revealed that rearrangement with MeNH2 proceeded largely with retention of configuration at phos-phorus. Stereochemical and competition studies on PhCHMeP(O)(Ph)NHOX (X = Ms or Ns) and studies on the enant-iomers of Ph2P(O)NHOS(O)2Camphor have provided strong evidence for phosphonamidic-sulphonic mixed anhydride RP(O)(NHPh)OX (X = Ms or Ns) involvement in the rearrangement. MeNH2 and ButNH2 also reacted with PhCHMeP(O)(Ph)NHOMs (SN2 at N) giving the hydrazides PhCHMeP(O)(Ph)NHNHR (R = Me or But). This was more important for ButNH2 and competition studies with (Me-C6H4-CH2)2P(O)NHONs using equimolar mixtures of ButNH2-ButMeNH and ButNH2-Pri2NH showed that ButMeNH was 11.5 times better than ButNH2 for hydrazide formation while ButNH2 was only slightly better than Pri2NH. Part 2 The diastereoisomers of the a-bromomethylphosphonamidate BrCH2P(O)(NHBut)OMenthyl react with PhCH2N+Me3 -OMe (QOMe) to give the aminomethylphosphonate ButNHCH2P(O)(OMe)OMenthyl and phosphoramidate ButMeNP(O)(OMe)OMenthyl products resulting from the breakdown of an azaphosphiridine oxide intermediate. Single crystal X-ray analysis revealed that the aminomethyl-phosphonate was formed with inversion of configuration at phosphorus and that the phosphoramidate was formed very largely with retention of configuration at phosphorus, prov-iding further evidence for azaphosphiridine oxide involvement. The a-bromomethylphosphonamidates BrCH2P(O)(NHBut)OR (R = Me, Cyclohexyl, or But) react with QOMe and KOBut to give the corresponding aminomethylphosphonate and phosphoramidate rearrangement products. It was found that bulky OR groups in the substrate and bulky alkoxides enhance the yield of the aminomethylphosphonate product.
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- 1993
8. Neural precursor cell-secreted TGF-[beta]2 redirects inflammatory monocyte-derived cells in CNS autoimmunity
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De Feo, Donatella, Merlini, Arianna, Brambilla, Elena, Ottoboni, Linda, Laterza, Cecilia, Menon, Ramesh, Srinivasan, Sundararajan, Farina, Cinthia, Manuel Garcia Manteiga, Jose, Butti, Erica, Bacigaluppi, Marco, Comi, Giancarlo, Greter, Melanie, and Martino, Gianvito
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Monocytes -- Research ,Dendritic cells -- Research ,Central nervous system -- Research ,Granulocyte-macrophage colony stimulating factor -- Research ,Multiple sclerosis -- Analysis -- Diagnosis -- Care and treatment ,Health care industry - Abstract
In multiple sclerosis, the pathological interaction between autoreactive Th cells and mononuclear phagocytes in the CNS drives initiation and maintenance of chronic neuroinflammation. Here, we found that intrathecal transplantation of neural stem/precursor cells (NPCs) in mice with experimental autoimmune encephalomyelitis (EAE) impairs the accumulation of inflammatory monocyte-derived cells (MCs) in the CNS, leading to improved clinical outcome. Secretion of IL-23, IL-1, and TNF-[alpha], the cytokines required for terminal differentiation of Th cells, decreased in the CNS of NPC-treated mice, consequently inhibiting the induction of GM-CSF-producing pathogenic Th cells. In vivo and in vitro transcriptome analyses showed that NPC-secreted factors inhibit MC differentiation and activation, favoring the switch toward an antiinflammatory phenotype. Tgfb2 /- NPCs transplanted into EAE mice were ineffective in impairing MC accumulation within the CNS and failed to drive clinical improvement. Moreover, intrathecal delivery of TGF-[beta]2 during the effector phase of EAE ameliorated disease severity. Taken together, these observations identify TGF-[beta]2 as the crucial mediator of NPC immunomodulation. This study provides evidence that intrathecally transplanted NPCs interfere with the CNS-restricted inflammation of EAE by reprogramming infiltrating MCs into antiinflammatory myeloid cells via secretion of TGF- [beta]2., Introduction Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS), representing the most common CNS inflammatory disorder and the second leading cause of disability in young [...]
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- 2017
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9. Cytokines Stimulate the Release of Microvesicles from Myeloid Cells Independently from the P2X7 Receptor/Acid Sphingomyelinase Pathway
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Federico Colombo, Mattia Bastoni, Annamaria Nigro, Paola Podini, Annamaria Finardi, Giacomo Casella, Menon Ramesh, Cinthia Farina, Claudia Verderio, and Roberto Furlan
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microvesicles ,inflammation ,cytokines ,myeloid cells ,multiple sclerosis ,transcription ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Microvesicles (MVs) are membrane particles of 200–500 nm released by all cell types constitutively. MVs of myeloid origin are found increased in the cerebrospinal fluid (CSF) of patients suffering from neuroinflammatory disorders, although the factors triggering their production have never been defined. Here, we report that both pro- and anti-inflammatory cytokines, specifically interferon-γ and interleukin-4, are equally able to stimulate the production of MVs from microglia cells and monocytes. Additionally, we found this process to be independent from the best characterized molecular pathway so far described for membrane shedding, which is centered on the purinergic receptor P2X7, whose activation by high concentrations of extracellular ATP (exATP) results in membrane blebbing operated by the secreted enzyme acid sphingomyelinase (ASMase). Moreover, a potent inhibitor of ASMase, injected in a mouse model of multiple sclerosis, failed to reduce the number of MVs in their CSF. This suggests that cytokines, rather than exATP, may exert a long-term control of MV production in the context of chronic inflammation, where both pro- and anti-inflammatory factors play coordinated roles.
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- 2018
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10. A learning experience in the use of high-frequency oscillatory ventilation in infants post-cardiac surgery
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Bansal, Nikhil, Chauhan, Abhinav Singh, and Menon, Ramesh Pariyarath
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- 2019
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11. VDAP-GUI: a user-friendly pipeline for variant discovery and annotation of raw next-generation sequencing data
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Menon, Ramesh, Patel, Namrata V., Mohapatra, Amitbikram, and Joshi, Chaitanya G.
- Published
- 2016
- Full Text
- View/download PDF
12. Neural precursor cell–secreted TGF-β2 redirects inflammatory monocyte-derived cells in CNS autoimmunity
- Author
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De Feo, Donatella, Merlini, Arianna, Brambilla, Elena, Ottoboni, Linda, Laterza, Cecilia, Menon, Ramesh, Srinivasan, Sundararajan, Farina, Cinthia, Garcia Manteiga, Jose Manuel, Butti, Erica, Bacigaluppi, Marco, Comi, Giancarlo, Greter, Melanie, and Martino, Gianvito
- Published
- 2017
- Full Text
- View/download PDF
13. South Asian medical cohorts reveal strong founder effects and high rates of homozygosity.
- Author
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Wall, Jeffrey D., Sathirapongsasuti, J. Fah, Gupta, Ravi, Rasheed, Asif, Venkatesan, Radha, Belsare, Saurabh, Menon, Ramesh, Phalke, Sameer, Mittal, Anuradha, Fang, John, Tanneeru, Deepak, Deshmukh, Manjari, Bassi, Akshi, Robinson, Jacqueline, Chaudhary, Ruchi, Murugan, Sakthivel, ul-Asar, Zameer, Saleem, Imran, Ishtiaq, Unzila, and Fatima, Areej
- Subjects
SOUTH Asians ,HUMAN genetics ,HOMOZYGOSITY ,WHOLE genome sequencing ,GENETIC variation ,REPRODUCTIVE isolation ,CONSANGUINITY - Abstract
The benefits of large-scale genetic studies for healthcare of the populations studied are well documented, but these genetic studies have traditionally ignored people from some parts of the world, such as South Asia. Here we describe whole genome sequence (WGS) data from 4806 individuals recruited from the healthcare delivery systems of Pakistan, India and Bangladesh, combined with WGS from 927 individuals from isolated South Asian populations. We characterize population structure in South Asia and describe a genotyping array (SARGAM) and imputation reference panel that are optimized for South Asian genomes. We find evidence for high rates of reproductive isolation, endogamy and consanguinity that vary across the subcontinent and that lead to levels of rare homozygotes that reach 100 times that seen in outbred populations. Founder effects increase the power to associate functional variants with disease processes and make South Asia a uniquely powerful place for population-scale genetic studies. South Asia is home to almost 2 billion people but is extremely underrepresented in human genetics. This study uses genomes from ~5,000 South Asians to characterize genetic variation and help facilitate future South Asian genetic studies. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
14. Knowledge gaps related to breastfeeding and immunization in the mothers of infants with congenital heart diseases: An urgent concern.
- Author
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Joshi, Poonam, Dhanya, V.A., Thuileiphy Tallanao, T., Bhati, Priyanka, Sharma, Rimple, and Menon, Ramesh P.
- Published
- 2023
- Full Text
- View/download PDF
15. Identification of putative SNPs in progressive retinal atrophy affected Canis lupus familiaris using exome sequencing
- Author
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Reddy, Bhaskar, Kelawala, Divyesh N., Shah, Tejas, Patel, Anand B., Patil, Deepak B., Parikh, Pinesh V., Patel, Namrata, Parmar, Nidhi, Mohapatra, Amit B., Singh, Krishna M., Menon, Ramesh, Pandya, Dipal, Jakhesara, Subhash J., Koringa, Prakash G., Rao, Mandava V., and Joshi, Chaitanya G.
- Published
- 2015
- Full Text
- View/download PDF
16. Near-chromosomal de novo assembly of Bengal tiger genome reveals genetic hallmarks of apex predation.
- Author
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Shukla, Harsh, Suryamohan, Kushal, Khan, Anubhab, Mohan, Krishna, Perumal, Rajadurai C, Mathew, Oommen K, Menon, Ramesh, Dixon, Mandumpala Davis, Muraleedharan, Megha, Kuriakose, Boney, Michael, Saju, Krishnankutty, Sajesh P, Zachariah, Arun, Seshagiri, Somasekar, and Ramakrishnan, Uma
- Subjects
TIGERS ,GENOMES ,GENE families ,GENETIC variation ,TRANSFER RNA ,CHROMOSOMES ,SMELL - Abstract
The tiger, a poster child for conservation, remains an endangered apex predator. Continued survival and recovery will require a comprehensive understanding of genetic diversity and the use of such information for population management. A high-quality tiger genome assembly will be an important tool for conservation genetics, especially for the Indian tiger, the most abundant subspecies in the wild. Here, we present high-quality near-chromosomal genome assemblies of a female and a male wild Indian tiger (Panthera tigris tigris). Our assemblies had a scaffold N50 of >140 Mb, with 19 scaffolds corresponding to the 19 numbered chromosomes, containing 95% of the genome. Our assemblies also enabled detection of longer stretches of runs of homozygosity compared to previous assemblies, which will help improve estimates of genomic inbreeding. Comprehensive genome annotation identified 26,068 protein-coding genes, including several gene families involved in key morphological features such as the teeth, claws, vision, olfaction, taste, and body stripes. We also identified 301 microRNAs, 365 small nucleolar RNAs, 632 transfer RNAs, and other noncoding RNA elements, several of which are predicted to regulate key biological pathways that likely contribute to the tiger's apex predatory traits. We identify signatures of positive selection in the tiger genome that are consistent with the Panthera lineage. Our high-quality genome will enable use of noninvasive samples for comprehensive assessment of genetic diversity, thus supporting effective conservation and management of wild tiger populations. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
17. Superior Mediastinal Syndrome Due to Intrathoracic Tuberculosis
- Author
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Sahu, Jitendra K., Menon, Ramesh P., Lodha, Rakesh, and Kabra, Sushil Kumar
- Published
- 2010
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- View/download PDF
18. Human Neurotrophin Receptor p75NTR Defines Differentiation-Oriented Skeletal Muscle Precursor Cells: Implications for Muscle Regeneration
- Author
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Colombo, Emanuela, Romaggi, Stefania, Medico, Enzo, Menon, Ramesh, Mora, Marina, Falcone, Chiara, Lochmüller, Hanns, Confalonieri, Paolo, Mantegazza, Renato, Morandi, Lucia, and Farina, Cinthia
- Published
- 2011
- Full Text
- View/download PDF
19. Understanding Startup Valuation and its Impact on Startup Ecosystem.
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Menon, Ramesh and James, Leena
- Subjects
BUSINESS success ,VENTURE capital ,ANGEL investors ,TECHNOLOGICAL innovations ,VALUATION ,NEW business enterprises ,VENTURE capital companies ,BUSINESS valuation - Abstract
Startups play a substantial role in the economic growth of a nation, by introducing new technologies, ground-breaking innovation, creating jobs, etc. A couple of decades back, it was extremely difficult to start a business, but today new businesses pop up every day, all around the world. Recognizing the importance of a startup, governments across the globe are doing their best to provide an atmosphere where startups can bloom. Despite its importance and all the support, the startup failure rate is at 90%; about 10% of startups fail in the first year and 70% fail in two to five years. The startup boom saw the emergence of alternative sources of funding like Venture Capitalist, Angel Investors, etc. These investors (Venture Capitalist, Angel Investors, etc.) played a crucial role in startup success by providing easy access to funds which is a critical and scarce resource for any founder. Traditionally business success is linked with sustainable profitability but in the startup world most used method to define success is valuation. Based on CB Insights research, as of January 2022, there are more than 900 unicorns (startup with a valuation of over $1 billion) around the world and of these unicorns less than 10% are profitable. It's difficult to explain/comprehend how startups' which are neither profitable nor foresee profitability in near future are valued higher than traditional business with stable profitability. Current valuation methods have impacted the startup ecosystem. Today, founders start their business with exit in mind, the focus of founders is on growth/scale rather than profitability. There is a school of thought that believes that such valuations will soon result in the bursting of the startup bubble just like the dotcom bubble seen in late 1990s. The focus of this paper is to investigate the techniques used by investors for startup valuation and how these techniques are impacting the startup ecosystem and its founders. The paper looks at all stages of the investment cycle, from seed to IPO or takeover and understands the process of valuation at each stage and how it impacts all stakeholders in the ecosystem. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
20. Pseudocyst of the auricle-a new method of treatment
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Ramalingam, Ravi, Ramalingam, K. K., and Menon, Ramesh
- Published
- 1998
- Full Text
- View/download PDF
21. Publication ethics during the Covid times: Reflections on research integrity, authorship, peer review and editorial policies.
- Author
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KUTTIATT, VIJESH SREEDHAR, MENON, RAMESH P., and KUMAR, ASHWANI
- Subjects
EDITORIAL policies ,COVID-19 ,AUTHORSHIP ,MEDICAL ethics - Abstract
The article presents the discussion on research ethics. Topics include recent circumstances prompting researchers to re-inform themselves about ethical aspects of not carrying out scientific investigations in human beings; and publication prompting the WHO and others to immediately suspend ongoing trials with chloroquine and hydroxychloroquine in patients with Covid-19.
- Published
- 2022
- Full Text
- View/download PDF
22. Nonrecursive Order N formulation of multibody dynamics
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Kurdila, Andrew J, Menon, Ramesh G, and Sunkel, John W
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Spacecraft Design, Testing And Performance - Published
- 1993
23. Nonrecursive formulations of multibody dynamics and concurrent multiprocessing
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Kurdila, Andrew J and Menon, Ramesh
- Subjects
Structural Mechanics - Abstract
Since the late 1980's, research in recursive formulations of multibody dynamics has flourished. Historically, much of this research can be traced to applications of low dimensionality in mechanism and vehicle dynamics. Indeed, there is little doubt that recursive order N methods are the method of choice for this class of systems. This approach has the advantage that a minimal number of coordinates are utilized, parallelism can be induced for certain system topologies, and the method is of order N computational cost for systems of N rigid bodies. Despite the fact that many authors have dismissed redundant coordinate formulations as being of order N(exp 3), and hence less attractive than recursive formulations, we present recent research that demonstrates that at least three distinct classes of redundant, nonrecursive multibody formulations consistently achieve order N computational cost for systems of rigid and/or flexible bodies. These formulations are as follows: (1) the preconditioned range space formulation; (2) penalty methods; and (3) augmented Lagrangian methods for nonlinear multibody dynamics. The first method can be traced to its foundation in equality constrained quadratic optimization, while the last two methods have been studied extensively in the context of coercive variational boundary value problems in computational mechanics. Until recently, however, they have not been investigated in the context of multibody simulation, and present theoretical questions unique to nonlinear dynamics. All of these nonrecursive methods have additional advantages with respect to recursive order N methods: (1) the formalisms retain the highly desirable order N computational cost; (2) the techniques are amenable to concurrent simulation strategies; (3) the approaches do not depend upon system topology to induce concurrency; and (4) the methods can be derived to balance the computational load automatically on concurrent multiprocessors. In addition to the presentation of the fundamental formulations, this paper presents new theoretical results regarding the rate of convergence of order N constraint stabilization schemes associated with the newly introduced class of methods.
- Published
- 1993
24. Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians.
- Author
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Wang, Minxian, Menon, Ramesh, Mishra, Sanghamitra, Patel, Aniruddh P., Chaffin, Mark, Tanneeru, Deepak, Deshmukh, Manjari, Mathew, Oshin, Apte, Sanika, Devanboo, Christina S., Sundaram, Sumathi, Lakshmipathy, Praveena, Murugan, Sakthivel, Sharma, Krishna Kumar, Rajendran, Karthikeyan, Santhosh, Sam, Thachathodiyl, Rajesh, Ahamed, Hisham, Balegadde, Aniketh Vijay, and Alexander, Thomas
- Subjects
- *
SOUTH Asians , *CORONARY disease , *ODDS ratio , *ASIAN studies , *RESEARCH , *GENETICS , *SEQUENCE analysis , *RESEARCH methodology , *CASE-control method , *EVALUATION research , *MEDICAL cooperation , *COMPARATIVE studies , *CORONARY artery disease , *RESEARCH funding - Abstract
Background: Genome-wide polygenic scores (GPS) integrate information from many common DNA variants into a single number. Because rates of coronary artery disease (CAD) are substantially higher among South Asians, a GPS to identify high-risk individuals may be particularly useful in this population.Objectives: This analysis used summary statistics from a prior genome-wide association study to derive a new GPSCAD for South Asians.Methods: This GPSCAD was validated in 7,244 South Asian UK Biobank participants and tested in 491 individuals from a case-control study in Bangladesh. Next, a static ancestry and GPSCAD reference distribution was built using whole-genome sequencing from 1,522 Indian individuals, and a framework was tested for projecting individuals onto this static ancestry and GPSCAD reference distribution using 1,800 CAD cases and 1,163 control subjects newly recruited in India.Results: The GPSCAD, containing 6,630,150 common DNA variants, had an odds ratio (OR) per SD of 1.58 in South Asian UK Biobank participants and 1.60 in the Bangladeshi study (p < 0.001 for each). Next, individuals of the Indian case-control study were projected onto static reference distributions, observing an OR/SD of 1.66 (p < 0.001). Compared with the middle quintile, risk for CAD was most pronounced for those in the top 5% of the GPSCAD distribution-ORs of 4.16, 2.46, and 3.22 in the South Asian UK Biobank, Bangladeshi, and Indian studies, respectively (p < 0.05 for each).Conclusions: The new GPSCAD has been developed and tested using 3 distinct South Asian studies, and provides a generalizable framework for ancestry-specific GPS assessment. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
25. Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation.
- Author
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Grassivaro, Francesca, Menon, Ramesh, Acquaviva, Massimo, Ottoboni, Linda, Ruffini, Francesca, Bergamaschi, Andrea, Muzio, Luca, Farina, Cinthia, and Martino, Gianvito
- Subjects
- *
MACROPHAGES , *MICROGLIA , *INFLAMMATION , *BONE marrow , *YOLK sac - Abstract
Differently from other myeloid cells, microglia derive exclusively from precursors originating within the yolk sac and migrate to the CNS under development, without any contribution from fetal liver or postnatal hematopoiesis. Consistent with their unique ontology, microglia may express specific physiological markers, which have been partly described in recent years. Here we wondered whether profiles distinguishing microglia from peripheral macrophages vary with age and under pathology. To this goal, we profiled transcriptomes of microglia throughout the lifespan and included a parallel comparison with peripheral macrophages under physiological and neuroinflammatory settings using age- and sex-matched wild-type and bone marrow chimera mouse models. This comprehensive approach demonstrated that the phenotypic differentiation between microglia and peripheral macrophages is age-dependent and that peripheral macrophages do express some of the most commonly described microglia-specific markers early during development, such as Fcrls, P2ryl2, Tmeml 19, and Trem2. Further, during chronic neuroinflammation CNS-infiltrating macrophages and not peripheral myeloid cells acquire microglial markers, indicating that the CNS niche may instruct peripheral myeloid cells to gain the phenotype and, presumably, the function of the microglia cell. In conclusion, our data provide further evidence about the plasticity of the myeloid cell and suggest caution in the strict definition and application of microglia-specific markers. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
26. TRANSLATIONAL BIOINFORMATICS AND SYSTEMS BIOLOGY APPROACHES TO GENETIC AND TRANSCRIPTIONAL DATA INCOMPLEX HUMAN DISORDERS
- Author
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MENON, RAMESH
- Abstract
Human complex diseases are caused by genetic and environmental factors. Genome-wide association studies (gwas) are aimed to identify common variants predisposing to those disorders. However, till date, the data generated from such studies have not been extensively explored to identify the molecular and functional framework hosting the susceptibility genes. We reconstructed the multiple sclerosis-MS genetic interactome and searched for their interactions with genes predisposing to either neurodegenerative or autoimmune diseases such as Parkinson's disease-PD, Alzheimer's disease-AD, multiple sclerosis-MS, rheumatoid arthritis-RA and Type 1 diabetes-T1D. It was observed that several genes predisposing to the other autoimmune or neurodegenerative disorders may come into contact with MS interactome, suggesting that susceptibility to distinct diseases may converge towards common molecular and biological networks. In order to test this hypothesis, we performed pathway enrichment analyses on each disease interactome independently. Several issues related to immune function and growth factor signaling pathways appeared in all autoimmune diseases. Further, the paired analyses of disease interactomes revealed significant molecular and functional relatedness among the diseases. Therefore, the shift from single genes to molecular frameworks via systems biology approach highlighted several known pathogenic processes, indicating that changes in these functions might be driven or sustained by the framework linked to genetic susceptibility. Notably, MS is a complex disease of the central nervous system (CNS), but many of the susceptibility genes play a role in immune system. Interestingly, the most widely used therapeutic drugs in MS are either immunosuppressive or immunomodulatory agents, indicating that targeting peripheral immune system is beneficial to patients with this CNS disorder. Next, we measured the global gene expression in peripheral blood mono nuclear cells (PBMCs) from MS and healthy subjects to discover disease genes, molecular biomarkers and drug targets. Extending the bioinformatics analysis of the transcriptome data to network-biology level enabled us to identify few crucial transcriptional regulators in MS. Further, as a first step towards translational research, studies were conducted in the animal model of MS, based on the outcomes of the bioinformatics analysis. Significant amelioration of disease activity was observed in diseased animals treated with drug targeting SP1 transcription factor, compared to the untreated group. Hence, disease transcriptomics combined with network-biology analysis provided a powerful platform for the identification of functional networks and molecular targets in MS.
- Published
- 2013
- Full Text
- View/download PDF
27. Dysregulation of MS risk genes and pathways at distinct stages of disease.
- Author
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Srinivasan, Sundararajan, Di Dario, Marco, Russo, Alessandra, Menon, Ramesh, Brini, Elena, Romeo, Marzia, Sangalli, Francesca, Costa, Gloria Dalla, Rodegher, Mariaemma, Radaelli, Marta, Moiola, Lucia, Cantarella, Daniela, Medico, Enzo, Martino, Gianvito, Furlan, Roberto, Martinelli, Vittorio, Comi, Giancarlo, and Farina, Cinthia
- Published
- 2017
- Full Text
- View/download PDF
28. Early enteral nutrition therapy in congenital cardiac repair postoperatively: A randomized, controlled pilot study.
- Author
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Sahu, Manoj Kumar, Menon, Ramesh, Singh, Sarvesh Pal, Singal, Anuradha, Mohan, Alka, Manral, Mala, Singh, Divya, Devagouru, V., Talwar, Sachin, and Choudhary, Shiv Kumar
- Subjects
- *
CONGENITAL heart disease , *BREAST milk , *INFANTS , *PEDIATRIC surgery , *CARDIAC surgery , *POSTOPERATIVE period - Abstract
Background and Objectives: Adequate nutritional supplementation in infants with cardiac malformations after surgical repair is a challenge. Critically ill infants in the early postoperative period are in a catabolic stress. The mismatch between estimated energy requirement (EER) and the intake in the postoperative period is multifactorial, predisposing them to complications such as immune deficiency, more infection, and growth failure. This study aimed to assess the feasibility and efficacy of enriched breast milk feed on postoperative recovery and growth of infants after open heart surgery.Methodology: Fifty infants <6 months of age were prospectively randomized in the trial for enteral nutrition (EN) postoperatively from day 1 to 10, after obtaining the Institute Ethics Committee's approval. They were equally divided into two groups on the basis of the feed they received: Control group was fed with expressed breast milk (EBM; 0.65 kcal/ml) and intervention group was fed with EBM + energy supplementation/fortification with human milk fortifier (7.5 kcal/2 g)/Simyl medium-chain triglyceride oil (7.8 kcal/ml). Energy need for each infant was calculated as per EER at 90 kcal/kg/day, as the target requirement. The intra- and post-operative variables such as cardiopulmonary bypass and aortic cross-clamp times, ventilation duration, Intensive Care Unit (ICU), and hospital length of stay and mortality were recorded. Anthropometric and hematological parameters and infection control data were recorded in a predesigned pro forma. Data were analyzed using Stata 14.1 software.Results: The duration of mechanical ventilation, length of ICU stay (LOIS), length of hospital stay (LOHS), infection rate, and mortality rate were lower in the intervention group compared to the control group although none of the differences were statistically significant. Infants in control group needed mechanical ventilation for about a day more (i.e., 153.6 ± 149.0 h vs. 123.2 ± 107.0 h; P = 0.20) than those in the intervention group. Similarly, infants in control group stayed for longer duration in the ICU (13.2 ± 8.9 days) and hospital (16.5 ± 9.8 days) as compared to the intervention group (11.0 ± 6.1 days; 14.1 ± 7.0 days) (P = 0.14 and 0.17, respectively). The LOIS and LOHS were decreased by 2.2 and 2.4 days, respectively, in the intervention group compared to control group. The infection rate (3/25; 5/25) and mortality rate (1/25; 2/25) were lower in the intervention group than those in the control group. The energy intake in the intervention group was 40 kcal more (i.e., 127.2 ± 56.1 kcal vs. 87.1 ± 38.3 kcal) than the control group on the 10th postoperative day.Conclusions: Early enteral/oral feeding after cardiac surgery is feasible and recommended. In addition, enriching the EBM is helpful in achieving the maximum possible calorie intake in the postoperative period. EN therapy might help in providing adequate nutrition, and it decreases ventilation duration, infection rate, LOIS, LOHS, and mortality. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
29. Incidence, microbiological profile of nosocomial infections, and their antibiotic resistance patterns in a high volume Cardiac Surgical Intensive Care Unit.
- Author
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Sahu, Manoj Kumar, Siddharth, Bharat, Choudhury, Arin, Vishnubhatla, Sreenivas, Pal Singh, Sarvesh, Menon, Ramesh, Kapoor, Poonam Malhotra, Talwar, Sachin, Choudhary, Shiv, Airan, Balram, and Singh, Sarvesh Pal
- Subjects
NOSOCOMIAL infections ,DRUG resistance in microorganisms ,COMPLICATIONS of cardiac surgery ,INTENSIVE care units ,CARDIOVASCULAR surgery ,DIAGNOSIS ,ANTIBIOTICS ,BACTERIA ,CRITICAL care medicine ,CROSS infection ,GRAM-negative bacteria ,GRAM-negative bacterial diseases ,LENGTH of stay in hospitals ,MICROBIAL sensitivity tests ,SURGICAL site infections ,DISEASE incidence ,RETROSPECTIVE studies ,PHARMACODYNAMICS - Abstract
Background: Nosocomial infections (NIs) in the postoperative period not only increase morbidity and mortality, but also impose a significant economic burden on the health care infrastructure. This retrospective study was undertaken to (a) evaluate the incidence, characteristics, risk factors and outcomes of NIs and (b) identify common microorganisms responsible for infection and their antibiotic resistance profile in our Cardiac Surgical Intensive Care Unit (CSICU).Patients and Methods: After ethics committee approval, the CSICU records of all patients who underwent cardiovascular surgery between January 2013 and December 2014 were reviewed retrospectively. The incidence of NI, distribution of NI sites, types of microorganisms and their antibiotic resistance, length of CSICU stay, and patient-outcome were determined.Results: Three hundred and nineteen of 6864 patients (4.6%) developed NI after cardiac surgery. Lower respiratory tract infections (LRTIs) accounted for most of the infections (44.2%) followed by surgical-site infection (SSI, 11.6%), bloodstream infection (BSI, 7.5%), urinary tract infection (UTI, 6.9%) and infections from combined sources (29.8%). Acinetobacter, Klebsiella, Escherichia coli, and Staphylococcus were the most frequent pathogens isolated in patients with LRTI, BSI, UTI, and SSI, respectively. The Gram-negative bacteria isolated from different sources were found to be highly resistant to commonly used antibiotics.Conclusion: The incidence of NI and sepsis-related mortality, in our CSICU, was 4.6% and 1.9%, respectively. Lower respiratory tract was the most common site of infection and Gram-negative bacilli, the most common pathogens after cardiac surgery. Antibiotic resistance was maximum with Acinetobacter spp. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
30. Single lumen tube as endobronchial stent to manage left bronchial compression post total anomalous pulmonary venous connection repair.
- Author
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Singh, Sarvesh Pal, Menon, Ramesh, Sahu, Manoj Kumar, Rajashekar, Palleti, and Kapoor, Poonam Malhotra
- Subjects
- *
PULMONARY veins , *TACHYPNEA , *HEART septum abnormalities - Abstract
The article describes the case of a 6-month-old female child with a history of respiratory distress, tachycardia, tachypnea, subcostal retractions and peripheral oxygen saturation. A diagnosis of obstructed supracardiac total anomalous pulmonary venous conncetion (TAPVC) with atrial septal defect (ASD) and severe pulmonary artery hypertension based on the results of transthoracic echocardiography and pre-operative chest X-ray. A single lumen endotracheal (ET) tube (ETT) was placed.
- Published
- 2015
- Full Text
- View/download PDF
31. Intrathecal transplantation of neural precursor cells impairs the effector phase of experimental autoimmune encephalomyelitis
- Author
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De Feo, Donatella, Merlini, Arianna, Brambilla, Elena, Laterza, Cecilia, Ruffini, Francesca, Menon, Ramesh, Farina, Cinthia, Comi, Giancarlo, Greter, Melanie, and Martino, Gianvito
- Published
- 2014
- Full Text
- View/download PDF
32. Microglia's gene expression at different stages of evolution and under pathological conditions
- Author
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Grassivaro, Francesca, Menon, Ramesh, Farina, Cinthia, Muzio, Luca, and Martino, Gianvito
- Published
- 2014
- Full Text
- View/download PDF
33. Peripheral transcriptional control in multiple sclerosis: Hepatocyte nuclear factor 4 alpha regulates immune cell activation and autoimmunity
- Author
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Di Dario, Marco, Menon, Ramesh, Colombo, Emanuela, Radaelli, Marta, Martinelli, Vittorio, Comi, Giancarlo, and Farina, Cinthia
- Published
- 2014
- Full Text
- View/download PDF
34. Modified blalock-taussig shunt and levosimendan for left ventricular preparation in a child with transposition of great arteries and regressed ventricle undergoing rapid 2 stage arterial switch operation.
- Author
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Kumar Sahu, Manoj, Gupta, Anish, Alam, Intekhab, Pal Singh, Sarvesh, Menon, Ramesh, Devagouru, V., Sahu, Manoj Kumar, and Singh, Sarvesh Pal
- Subjects
TRANSPOSITION of great vessels ,ARTERIAL catheterization ,REPORTING of diseases ,LEVOSIMENDAN - Abstract
Rapid two-stage arterial switch operation (ASO) is very relevant as many patients of transposition of great arteries (TGA) present late to the hospital when primary switch either is not possible or carries a high risk of morbidity and mortality. Hence, other means apart from the traditional methods of left ventricle preparedness should be tried to help this category of patients, who are to undergo rapid two-stage ASO. We successfully used levosimendan and continuous positive airway pressure after 1st stage operation in a patient with dTGA and regressed ventricle, which helped in left ventricular preparedness, and the child underwent rapid two-stage ASO uneventfully. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
35. Molecular and functional definition of the developing human striatum.
- Author
-
Onorati, Marco, Castiglioni, Valentina, Biasci, Daniele, Cesana, Elisabetta, Menon, Ramesh, Vuono, Romina, Talpo, Francesca, Goya, Rocio Laguna, Lyons, Paul A, Bulfamante, Gaetano P, Muzio, Luca, Martino, Gianvito, Toselli, Mauro, Farina, Cinthia, Barker, Roger A, Biella, Gerardo, and Cattaneo, Elena
- Subjects
CEREBRAL cortex ,HIPPOCAMPUS (Brain) ,CINGULATE cortex ,NEURONS ,NEUROSCIENCES - Abstract
The complexity of the human brain derives from the intricate interplay of molecular instructions during development. Here we systematically investigated gene expression changes in the prenatal human striatum and cerebral cortex during development from post-conception weeks 2 to 20. We identified tissue-specific gene coexpression networks, differentially expressed genes and a minimal set of bimodal genes, including those encoding transcription factors, that distinguished striatal from neocortical identities. Unexpected differences from mouse striatal development were discovered. We monitored 36 determinants at the protein level, revealing regional domains of expression and their refinement, during striatal development. We electrophysiologically profiled human striatal neurons differentiated in vitro and determined their refined molecular and functional properties. These results provide a resource and opportunity to gain global understanding of how transcriptional and functional processes converge to specify human striatal and neocortical neurons during development. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
36. Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons.
- Author
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Carri, Alessia Delli, Onorati, Marco, Lelos, Mariah J., Castiglioni, Valentina, Faedo, Andrea, Menon, Ramesh, Camnasio, Stefano, Vuono, Romina, Spaiardi, Paolo, Talpo, Francesca, Toselli, Mauro, Martino, Gianvito, Barker, Roger A., Dunnett, Stephen B., Biella, Gerardo, and Cattaneo, Elena
- Subjects
PLURIPOTENT stem cells ,CELL differentiation ,NEURONS ,NEOSTRIATUM ,NEURODEGENERATION ,HUNTINGTON disease - Abstract
Medium-sized spiny neurons (MSNs) are the only neostriatum projection neurons, and their degeneration underlies some of the clinical features of Huntington's disease. Using knowledge of human developmental biology and exposure to key neurodevelopmental molecules, human pluripotent stem (hPS) cells were induced to differentiate into MSNs. In a feeder-free adherent culture, ventral telencephalic specification is induced by BMP/TGF? inhibition and subsequent SHH/DKK1 treatment. The emerging FOXG1
+ /GSX2+ telencephalic progenitors are then terminally differentiated, resulting in the systematic line-independent generation of FOXP1+ /FOXP2+ /CTIP2+ /calbindin+ /DARPP-32+ MSNs. Similar to mature MSNs, these neurons carry dopamine and A2a receptors, elicit a typical firing pattern and show inhibitory postsynaptic currents, as well as dopamine neuromodulation and synaptic integration ability in vivo. When transplanted into the striatum of quinolinic acid-lesioned rats, hPS-derived neurons survive and differentiate into DARPP-32+ neurons, leading to a restoration of apomorphine-induced rotation behavior. In summary, hPS cells can be efficiently driven to acquire a functional striatal fate using an ontogeny-recapitulating stepwise method that represents a platform for in vitro human developmental neurobiology studies and drug screening approaches. [ABSTRACT FROM AUTHOR]- Published
- 2013
- Full Text
- View/download PDF
37. Shared Molecular and Functional Frameworks among Five Complex Human Disorders: A Comparative Study on Interactomes Linked to Susceptibility Genes.
- Author
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Menon, Ramesh and Farina, Cinthia
- Subjects
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DISEASES , *MICROBIAL sensitivity tests , *GENES , *NEURODEGENERATION , *AUTOIMMUNE diseases , *ALZHEIMER'S disease , *MULTIPLE sclerosis , *RHEUMATOID arthritis , *GENETICS - Abstract
Background: Genome-wide association studies (gwas) are invaluable in revealing the common variants predisposing to complex human diseases. Yet, until now, the large volumes of data generated from such analyses have not been explored extensively enough to identify the molecular and functional framework hosting the susceptibility genes. Methodology/Principal Findings: We investigated the relationships among five neurodegenerative and/or autoimmune complex human diseases (Parkinson's disease-Park, Alzheimer's disease-Alz, multiple sclerosis-MS, rheumatoid arthritis-RA and Type 1 diabetes-T1D) by characterising the interactomes linked to their gwas-genes. An initial study on the MS interactome indicated that several genes predisposing to the other autoimmune or neurodegenerative disorders may come into contact with it, suggesting that susceptibility to distinct diseases may converge towards common molecular and biological networks. In order to test this hypothesis, we performed pathway enrichment analyses on each disease interactome independently. Several issues related to immune function and growth factor signalling pathways appeared in all autoimmune diseases, and, surprisingly, in Alzheimer's disease. Furthermore, the paired analyses of disease interactomes revealed significant molecular and functional relatedness among autoimmune diseases, and, unexpectedly, between T1D and Alz. Conclusions/Significance: The systems biology approach highlighted several known pathogenic processes, indicating that changes in these functions might be driven or sustained by the framework linked to genetic susceptibility. Moreover, the comparative analyses among the five genetic interactomes revealed unexpected genetic relationships, which await further biological validation. Overall, this study outlines the potential of systems biology to uncover links between genetics and pathogenesis of complex human disorders. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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38. Exact Linearization of Nonlinear Manipulator Models using Adaptive Control.
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Menon, Ramesh G. and Garg, Devendra P.
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- 1988
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39. Substituent effects in reductions of heteroaromatic cations.
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Heyes, David, Menon, Ramesh S., Watt, C. Ian. F., Wiseman, Jake, and Kubinski, Przemyslaw
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- 2002
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40. Substituent effects in cyanoborohydride reductions of heterocyclic aromatic cations.
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Beddoes, Roy, Heyes, David, Menon, Ramesh S., and Watt, C. Ian. F.
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- 1996
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41. Stereospecificity in the rearrangement reactions of an N-phosphinoyl-O-sulfonylhydroxylamine with methylamine and tert-butylamine: retention of configuration at phosphorus as evidence for the initial formation of a phosphonamidic sulfonic mixed anhydride.
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Harger, Martin J. P. and Sreedharan-Menon, Ramesh
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- 1994
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42. Lossen-like rearrangement of N-[α-methylbenzyl(phenyl)phosphinoyl]-O-methylsulfonylhydroxylamine with methylamine: retention of configuration at phosphorus as revealed by X-ray crystallography.
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Fawcett, John, Harger, Martin J. P., and Menon, Ramesh Sreedharan
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- 1992
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43. Base induced rearrangement of an α-bromophosphonamidate: stereochemistry of ring opening of the azaphosphiridine oxide intermediate as revealed by X-ray crystallography.
- Author
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Fawcett, John, Harger, Martin J. P., Russell, David R., and Sreedharan-Menon, Ramesh
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- 1993
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44. High blood tacrolimus and hyperkalemia in a heart transplant patient.
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Kumar Sahu, Manoj, Pal Singh, Sarvesh, Das, Anupam, Abraham, Atul, Airan, Balram, Alam, Intekhab, Menon, Ramesh, Devagourou, V., Gupta, Anish, Sahu, Manoj Kumar, and Singh, Sarvesh Pal
- Subjects
HEART transplantation complications ,TACROLIMUS ,HYPERKALEMIA ,DILATED cardiomyopathy ,ECHOCARDIOGRAPHY ,CORTISONE ,THERAPEUTICS ,HEART transplantation ,IMMUNOSUPPRESSIVE agents - Abstract
The article presents a case study of a 43-year-old woman who experienced complications after undergoing an orthotopic heart transplantation (OHT) for her dilated cardiomyopathy. The patient then went for an echocardiography test which showed a mild right ventricle dysfunction and risk of developing hyperkalemia. The article also discusses the drug effectiveness of fludrocortisone as treatment for hyperkalemia.
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- 2017
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45. Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination
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Mohan, Hema, Friese, Anita, Albrecht, Stefanie, Krumbholz, Markus, Elliott, Christina L., Arthur, Ariel, Menon, Ramesh, Farina, Cinthia, Junker, Andreas, Stadelmann, Christine, Barnett, Susan C., Huitinga, Inge, Wekerle, Hartmut, Hohlfeld, Reinhard, Lassmann, Hans, Kuhlmann, Tanja, Linington, Christopher, Meinl, Edgar, and Netherlands Institute for Neuroscience (NIN)
- Subjects
Multiple Sclerosis ,Gene Expression Profiling ,Interleukin-8 ,Fibroblast growth factor ,Brain ,Leukemia Inhibitory Factor ,White Matter ,Mice, Inbred C57BL ,Rats, Sprague-Dawley ,Tissue Culture Techniques ,Mice ,Oligodendroglia ,Remyelination ,Spinal Cord ,Astrocytes ,Animals ,Fibroblast Growth Factor 1 ,Humans ,RNA, Messenger ,Demyelination ,Rats, Wistar ,Cells, Cultured ,Myelin Sheath ,Research Article - Abstract
Chronic demyelination is a pathological hallmark of multiple sclerosis (MS). Only a minority of MS lesions remyelinates completely. Enhancing remyelination is, therefore, a major aim of future MS therapies. Here we took a novel approach to identify factors that may inhibit or support endogenous remyelination in MS. We dissected remyelinated, demyelinated active, and demyelinated inactive white matter MS lesions, and compared transcript levels of myelination and inflammation-related genes using quantitative PCR on customized TaqMan Low Density Arrays. In remyelinated lesions, fibroblast growth factor (FGF) 1 was the most abundant of all analyzed myelination-regulating factors, showed a trend towards higher expression as compared to demyelinated lesions and was significantly higher than in control white matter. Two MS tissue blocks comprised lesions with adjacent de- and remyelinated areas and FGF1 expression was higher in the remyelinated rim compared to the demyelinated lesion core. In functional experiments, FGF1 accelerated developmental myelination in dissociated mixed cultures and promoted remyelination in slice cultures, whereas it decelerated differentiation of purified primary oligodendrocytes, suggesting that promotion of remyelination by FGF1 is based on an indirect mechanism. The analysis of human astrocyte responses to FGF1 by genome wide expression profiling showed that FGF1 induced the expression of the chemokine CXCL8 and leukemia inhibitory factor, two factors implicated in recruitment of oligodendrocytes and promotion of remyelination. Together, this study presents a transcript profiling of remyelinated MS lesions and identified FGF1 as a promoter of remyelination. Modulation of FGF family members might improve myelin repair in MS. Electronic supplementary material The online version of this article (doi:10.1186/s40478-014-0168-9) contains supplementary material, which is available to authorized users.
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46. Coronavirus disease 2019 in children: Clinical & epidemiological implications.
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Kuttiatt, Vijesh, Abraham, Philip, Menon, Ramesh, Vaidya, Pankaj, and Rahi, Manju
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COVID-19 , *JUVENILE diseases , *INFECTION prevention , *SYMPTOMS , *INFECTION control - Abstract
Despite the global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, there are limited data emerging in children. This review provides an update on clinical features, diagnosis, epidemiology, management and prevention of coronavirus disease 2019 (COVID-19) in children. Specific characteristics noted in children and their implications in disease management as well as transmission control are highlighted. Besides respiratory symptoms, gastrointestinal and atypical features such as chilblains, neurological symptoms and multisystem inflammation are also reported. Younger infants and those with comorbidity were found to be at risk of severe illness. Infected pregnant women and neonates were reported to have good prognosis. It is possible to manage the children with mild disease at home, with strict infection prevention control measures; severely affected require respiratory support and intensive care management. There are anecdotal reports of using antiviral and immunomodulatory drugs, benefit of which needs to be confirmed in clinical trials. A significant percentage of asymptomatic infection in children has epidemiological implication as these may act as links in transmission chain in the community. There is a need for systematic data on extra-pulmonary manifestations and atypical features, risk factors of severity, role of imaging and biomarkers, testing and management strategies and trials with antivirals and immunomodulatory drugs in children. The psychosocial effects of quarantine, closure of schools, lack of play activities and impact of lockdown need to be addressed. Understanding the biological basis for the profound age-dependent differential outcome of COVID-19 infection is important. Elucidating the protective mechanisms in children may aid in developing novel treatment strategies. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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47. Rearrangement reactions of N-phosphinoyl-O-sulfonylhydroxylamines with amines: detection of a phosphonamidic–sulfonic mixed anhydride intermediate by nuclear magnetic resonance spectroscopy.
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Harger, Martin J. P. and Sreedharan-Menon, Ramesh
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- 1996
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48. Asymmetric induction in the base induced rearrangement of N-(diphenylphosphinoyl)-O-(camphor-10-sulfonyl)hydroxylamine.
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Harger, Martin J. P. and Sreedharan-Menon, Ramesh
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- 1994
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49. HNF4α, SP1 and c-myc are master regulators of CNS autoimmunity.
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Colombo, Emanuela, Di Dario, Marco, Menon, Ramesh, Valente, Maria Maddalena, Bassani, Claudia, Sarno, Nicole, Mazza, Davide, Montini, Federico, Moiola, Lucia, Comi, Giancarlo, Martinelli, Vittorio, and Farina, Cinthia
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HEPATOCYTE nuclear factors , *GENE regulatory networks , *AUTOIMMUNITY , *AUTOIMMUNE diseases , *NETWORK hubs , *HUMAN biology - Abstract
Hepatocyte nuclear factor 4 α (HNF4α), a transcription factor (TF) essential for embryonic development, has been recently shown to regulate the expression of inflammatory genes. To characterize HNF4a function in immunity, we measured the effect of HNF4α antagonists on immune cell responses in vitro and in vivo. HNF4α blockade reduced immune activation in vitro and disease severity in the experimental model of multiple sclerosis (MS). Network biology studies of human immune transcriptomes unraveled HNF4α together with SP1 and c-myc as master TF regulating differential expression at all MS stages. TF expression was boosted by immune cell activation, regulated by environmental MS risk factors and higher in MS immune cells compared to controls. Administration of compounds targeting TF expression or function demonstrated non-synergic, interdependent transcriptional control of CNS autoimmunity in vitro and in vivo. Collectively, we identified a coregulatory transcriptional network sustaining neuroinflammation and representing an attractive therapeutic target for MS and other inflammatory disorders. • HNF4α supports monocyte and T cell function. • HNF4α, SP1 and c-myc are shared transcription factor network hubs among MS stages. • Hub levels are higher in MS immune cells and regulated by environmental risk factors. • Hubs exert non-synergic, interdependent control of CNS autoimmunity in vivo. [ABSTRACT FROM AUTHOR]
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- 2023
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50. iPSC-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of LIF.
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Laterza, Cecilia, Merlini, Arianna, De Feo, Donatella, Ruffini, Francesca, Menon, Ramesh, Onorati, Marco, Fredrickx, Evelien, Muzio, Luca, Lombardo, Angelo, Comi, Giancarlo, Quattrini, Angelo, Taveggia, Carla, Farina, Cinthia, Cattaneo, Elena, and Martino, Gianvito
- Published
- 2013
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