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ABSTRACTThis open-label, randomized, phase 3 study in China (V260-074; NCT04481191) evaluated the immunogenicity and safety of concomitant and staggered administration of three doses of an oral, live, pentavalent rotavirus vaccine (RV5) and three doses of an intramuscular, inactivated poliomyelitis vaccine (IPV) in 400 healthy infants. The primary objective was the non-inferiority of neutralizing antibody (nAb) responses in the concomitant- versus the staggered-use groups. Antibody responses were measured at baseline and 1-month post-dose 3 (PD3). Parents/legal guardians recorded adverse events for 30 or 15 d after study vaccinations in the concomitant-use or staggered-use groups, respectively. At PD3, >98% of participants seroconverted to all three poliovirus types, and the primary objective was met as lower bounds of the two-sided 95% CI for between-group difference in nAb seroconversion percentages ranged from − 4.3% to − 1.6%, for all poliovirus types, p

Abstract The domestic health care system has been facing a difficult task, especially in medical care, and Chinese nurses are under tremendous psychological pressure. Psychological support is a protective factor to relieve stress. This study examined the stress level and characteristics of Chinese nurses with different psychological support-seeking behaviours. Data from online questionnaires for this cross-sectional study were collected between January 2020 and February 2020 and yielded 2248 valid questionnaires for analysis with a response rate of 99.8%. General information of the respondents was also collected. The nurses’ stress levels were assessed using the Perceived Stress Scale (PSS-10). T tests, chi-square tests, and linear regression were used to examine the relationships among the factors. The results of this survey showed that between January and February 2020, 26.9% of nurses received psychological counselling, and the proportion was higher among men and nurses with lower education. The PSS-10 was related to gender, age group, provincial severity, and confidence in the control of the epidemic. The results showed that psychological support can effectively improve the confidence of domestic nurses in the face of arduous work and effectively relieve the psychological pressure caused by a heavy workload.

ObjectiveThis study investigates the prevalence of everyday functional impairment among older adults with schizophrenia and builds a predictive model of functional decline.MethodsA total of 113 hospitalized older patients enrolled in this study. Functional impairment is defined according to the Functional Activities Questionnaire (FAQ). Patients who scored

In this study, we use numerical methods to study the acoustic streaming effect of the acoustic black hole (ABH). Firstly, we build an ABH model to study the acoustic streaming effect. By deriving the waves equations and solving the Navier–Stokes equations, we obtain the flow field, sound field, and temperature field under the acoustic excitation. Secondly, the simulation result reveals the mechanism of acoustic streaming effects on the sound transmission characteristics of cavity ABH. The numerical results show that the abrupt decrease in the sound pressure is caused by the great changes in the velocity gradient caused by the catastrophe of cross section. The energy of the sound waves can also be dissipated by the thermal viscous layer at low frequencies. Finally, based on the acoustic streaming effects of the acoustic medium in the ABH, we propose feasible methods to enhance the sound insulation. Increasing the cross section of the cavity in ABH can get a better sound insulation effect at high frequencies, and decreasing the cross section can improve Sound Transmission Loss (STL). Through optimization, STL can reach more than 25 dB at low frequencies.