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257 results on '"McCracken, George H."'

1. Executive Summary: The Management of Community-Acquired Pneumonia in Infants and Children Older Than 3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America

Author

Bradley, John S., Byington, Carrie L., Shah, Samir S., Alverson, Brian, Carter, Edward R., Harrison, Christopher, Kaplan, Sheldon L., Mace, Sharon E., McCracken, George H., Moore, Matthew R., Peter, Shawn D. St, Stockwell, Jana A., and Swanson, Jack T.

Published
2011
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5. Mycoplasma pneumoniae Pneumonia in a Mouse Model

Author

Wubbel, Loretta, Jafri, Hasan S., Olsen, Kurt, Shelton, Sharon, Rogers, Beverly Barton, Gambill, Ginger, Patel, Padma, Keyser, Enid, Cassell, Gail, and McCracken, George H.

Published
1998

8. Effect of the 7-valent pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae in the first 2 years of life

Author

Ghaffar, Faryal, Barton, Theresa, Lozano, Juanita, Muniz, Luz Stella, Hicks, Patricia, Gan, Vanthaya, Ahmad, Naveed, and McCracken, George H., Jr.

Subjects
Pneumococcal vaccine -- Research, Pneumococcal vaccine -- Dosage and administration, Streptococcus pneumoniae -- Prevention, Streptococcus pneumoniae -- Research, Health, Health care industry
Published
2004

9. Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children

Author

Michelow, Ian C., Olsen, Kurt, Lozano, Juanita, Rollins, Nancy K., Duffy, Lynn B., Ziegler, Thedi, Kauppila, Jaana, Leinonen, Maija, and McCracken, George H., Jr

Subjects
Pneumococcal vaccine -- Health aspects, Pneumococcal vaccine -- Research, Respiratory tract infections -- Research, Pneumonia -- Care and treatment, Pneumonia -- Research, Bacterial pneumonia -- Care and treatment, Bacterial pneumonia -- Research, Children -- Health aspects
Abstract

Objectives. The precise epidemiology of childhood pneumonia remains poorly defined. Accurate and prompt etiologic diagnosis is limited by inadequate clinical, radiologic, and laboratory diagnostic methods. The objective of this study was to determine as precisely as possible the epidemiology and morbidity of community-acquired pneumonia in hospitalized children. Methods. Consecutive immunocompetent children hospitalized with radiographically confirmed lower respiratory infections (LRIs) were evaluated prospectively from January 1999 through March 2000. Positive blood or pleural fluid cultures or pneumolysin-based polymerase chain reaction assays, viral direct fluorescent antibody tests, or viral, mycoplasmal, or chlamydial serologic tests were considered indicative of infection by those organisms. Methods for diagnosis of pneumococcal pneumonia among study subjects were published by us previously. Selected clinical characteristics, indices of inflammation (white blood cell and differential counts and procalcitonin values), and clinical outcome measures (time to defervescence and duration of oxygen supplementation and hospitalization) were compared among groups of children. Results. One hundred fifty-four hospitalized children with LRIs were enrolled. Median age was 33 months (range: 2 months to 17 years). A pathogen was identified in 79% of children. Typical respiratory bacteria were identified in 60% (of which 73% were Streptococcus pneumoniae) viruses in 45%, Mycoplasma pneumoniae in 14%, Chlamydia pneumoniae in 9%, and mixed bacterial/ viral infections in 23%. Preschool-aged children had as many episodes of atypical bacterial LRIs as older children. Children with typical bacterial or mixed bacterial/ viral infections had the greatest inflammation and disease severity. Multivariate logistic-regression analyses revealed that high temperature ([greater than or equal to] 38.4[degrees]C) within 72 hours after admission (odds ratio: 2.2; 95% confidence interval; 1.4-3.5) and the presence of pleural effusion (odds ratio: 6.6; 95% confidence interval: 2.1-21.2) were significantly associated with bacterial pneumonia. Conclusions. This study used an expanded diagnostic armamentarium to define the broad spectrum of pathogens that cause pneumonia in hospitalized children. The data confirm the importance of S pneumoniae and the frequent occurrence of bacterial and viral coinfections in children with pneumonia. These findings will facilitate age-appropriate antibiotic selection and future evaluation of the clinical effectiveness of the pneumococcal conjugate vaccine as well as other candidate vaccines. Pediatrics 2004;113:701-707; community-acquired pneumonia, child, epidemiology, diagnosis, etiology, hospitalized., The quest to define accurately and promptly the causative agents of lower respiratory infections (LRIs) in children has been impeded by inadequate clinical, radiologic, and laboratory diagnostic methods. A limited [...]

Published
2004

20. Glycerol and bacterial meningitis

Author

Saez-Llorens, Xavier and McCracken, George H. Jr.

Subjects
Hemophilus meningitis -- Causes of, Hemophilus meningitis -- Development and progression, Hemophilus meningitis -- Care and treatment, Glycerin -- Dosage and administration, Glycerin -- Physiological aspects, Glycerol -- Dosage and administration, Glycerol -- Physiological aspects, Hemophilus influenzae -- Health aspects, Health, Health care industry
Published
2007

23. Commentary on Practice Guidelines

Author

Baraff, Larry J., Schriger, David L., Bass, James W., Fleisher, Gary R., Klein, Jerome O., McCracken, George H. Jr, and Powell, Keith R.

Published
1997

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