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8 results on '"Maurizy, Chloé"'

2. Loss of primary cilia promotes inflammation and carcinogenesis

Author

Paul, Conception, Tang, Ruizhi, Longobardi, Ciro, Lattanzio, Rossano, Eguether, Thibaut, Turali, Hulya, Bremond, Julie, Maurizy, Chloé, Gabola, Monica, Poupeau, Sophie, Turtoi, Andrei, Denicolai, Emilie, Cufaro, Maria Concetta, Svrcek, Magali, Seksik, Philippe, Castronovo, Vincent, Delvenne, Philippe, de Laurenzi, Vincenzo, Da Costa, Quentin, Bertucci, François, Lemmers, Bénédicte, Pieragostino, Damiana, Mamessier, Emilie, Janke, Carsten, Pinet, Valérie, and Hahne, Michael

Published
2022
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3. Author Correction: The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium

Author

Maurizy, Chloé, Abeza, Claire, Lemmers, Bénédicte, Gabola, Monica, Longobardi, Ciro, Pinet, Valérie, Ferrand, Marina, Paul, Conception, Bremond, Julie, Langa, Francina, Gerbe, François, Jay, Philippe, Verheggen, Céline, Tinari, Nicola, Helmlinger, Dominique, Lattanzio, Rossano, Bertrand, Edouard, Hahne, Michael, and Pradet-Balade, Bérengère

Published
2022
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5. Deep Structural Analysis of RPAP3 and PIH1D1, Two Components of the HSP90 Co-chaperone R2TP Complex

Author

Henri, Julien, Chagot, Marie-Eve, Bourguet, Maxime, Abel, Yoann, Terral, Guillaume, Maurizy, Chloé, Aigueperse, Christelle, Georgescauld, Florian, Vandermoere, Franck, Saint-Fort, Rénette, Behm-Ansmant, Isabelle, Charpentier, Bruno, Pradet-Balade, Bérengère, Verheggen, Céline, Bertrand, Edouard, Meyer, Philippe, Cianférani, Sarah, Manival, Xavier, and Quinternet, Marc

Published
2018
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6. In Vitro Corticogenesis from Embryonic Stem Cells Recapitulates the In Vivo Epigenetic Control of Imprinted Gene Expression

Author

Bouschet, Tristan, Dubois, Emeric, Reynès, Christelle, Kota, Satya K., Rialle, Stéphanie, Maupetit-Méhouas, Stéphanie, Pezet, Mikael, Le Digarcher, Anne, Nidelet, Sabine, Demolombe, Vincent, Cavelier, Patricia, Meusnier, Céline, Maurizy, Chloé, Sabatier, Robert, Feil, Robert, Arnaud, Philippe, Journot, Laurent, and Varrault, Annie

Published
2017
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7. The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones.

Author

Maurizy, Chloé, Quinternet, Marc, Abel, Yoann, Verheggen, Céline, Santo, Paulo E., Bourguet, Maxime, Paiva, Ana C.F., Bragantini, Benoît, Chagot, Marie-Eve, Robert, Marie-Cécile, Abeza, Claire, Fabre, Philippe, Fort, Philippe, Vandermoere, Franck, Sousa, Pedro M.F., Rain, Jean-Christophe, Charpentier, Bruno, Cianférani, Sarah, Bandeiras, Tiago M., and Pradet-Balade, Bérengère

Abstract

R2TP is an HSP90 co-chaperone that assembles important macro-molecular machineries. It is composed of an RPAP3-PIH1D1 heterodimer, which binds the two essential AAA+ATPases RUVBL1/RUVBL2. Here, we resolve the structure of the conserved C-terminal domain of RPAP3, and we show that it directly binds RUVBL1/RUVBL2 hexamers. The human genome encodes two other proteins bearing RPAP3-C-terminal-like domains and three containing PIH-like domains. Systematic interaction analyses show that one RPAP3-like protein, SPAG1, binds PIH1D2 and RUVBL1/2 to form an R2TP-like complex termed R2SP. This co-chaperone is enriched in testis and among 68 of the potential clients identified, some are expressed in testis and others are ubiquitous. One substrate is liprin-α2, which organizes large signaling complexes. Remarkably, R2SP is required for liprin-α2 expression and for the assembly of liprin-α2 complexes, indicating that R2SP functions in quaternary protein folding. Effects are stronger at 32 °C, suggesting that R2SP could help compensating the lower temperate of testis. [ABSTRACT FROM AUTHOR]

Published
2018
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8. Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer.

Author

Guo, Yuchen, Gabola, Monica, Lattanzio, Rossano, Paul, Conception, Pinet, Valérie, Ruizhi Tang, Tural, Hulya, Bremond, Julie, Longobardi, Ciro, Maurizy, Chloé, Da Costa, Quentin, Finetti, Pascal, Boissière-Michot, Florence, Rivière, Benjamin, Lemmers, Céline, Garnier, Séverine, Bertucci, François, Zlobec, Inti, Chebli, Karim, and Tazi, Jamal

Subjects
*PROGNOSIS, *CYCLINS, *COLORECTAL cancer, *COLON (Anatomy), *HOMEOSTASIS
Abstract

To clarify the function of cyclin A2 in colon homeostasis and colorectal cancer (CRC), we generated mice deficient for cyclin A2 in colonic epithelial cells (CECs). Colons of these mice displayed architectural changes in the mucosa and signs of inflammation, as well as increased proliferation of CECs associated with the appearance of low- and high-grade dysplasias. The main initial events triggering those alterations in cyclin A2-deficient CECs appeared to be abnormal mitoses and DNA damage. Cyclin A2 deletion in CECs promoted the development of dysplasia and adenocarcinomas in a murine colitis-associated cancer model. We next explored the status of cyclin A2 expression in clinical CRC samples at the mRNA and protein levels and found higher expression in tumors of patients with stage 1 or 2 CRC compared with those of patients with stage 3 or 4 CRC. A meta-analysis of 11 transcriptome data sets comprising 2239 primary CRC tumors revealed different expression levels of CCNA2 (the mRNA coding for cyclin A2) among the CRC tumor subtypes, with the highest expression detected in consensus molecular subtype 1 (CMS1) and the lowest in CMS4 tumors. Moreover, we found high expression of CCNA2 to be a new, independent prognosis factor for CRC tumors. [ABSTRACT FROM AUTHOR]

Published
2021
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