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216 results on '"Matsumoto, Yuka"'

39. Risk Stratification for Pregnancies Diagnosed With Fetal Growth Restriction Based on Placental MRI.

Author

Himoto, Yuki, Fujimoto, Koji, Kido, Aki, Otani, Satoshi, Matsumoto, Yuka Kuriyama, Mogami, Haruta, Nakao, Kyoko Kameyama, Kurata, Yasuhisa, Moribata, Yusaku, Chigusa, Yoshitsugu, Minamiguchi, Sachiko, Mandai, Masaki, and Nakamoto, Yuji

Subjects
FETAL growth retardation, ABRUPTIO placentae, ECHO-planar imaging, MANN Whitney U Test, PLACENTA, PREGNANCY outcomes
Abstract

Background: Diagnosis of fetal growth restriction (FGR) entails difficulties with differentiating fetuses not fulfilling their growth potential because of pathologic conditions, such as placental insufficiency, from constitutionally small fetuses. The feasibility of placental MRI for risk stratification among pregnancies diagnosed with FGR remains unexplored. Purpose: To explore quantitative MRI features useful to identify pregnancies with unfavorable outcomes and to assess the diagnostic performance of visual analysis of MRI to detect pregnancies with unfavorable outcomes, among pregnancies diagnosed with FGR. Study Type: Retrospective. Population: Thirteen pregnancies with unfavorable outcomes (preterm emergency cesarean section or intrauterine fetal death) and 11 pregnancies with favorable outcomes performed MRI at gestational weeks 21–36. Field Strength/Sequence: A 5‐T, half‐Fourier‐acquired single‐shot turbo spin echo (HASTE), spin‐echo echo‐planar imaging (SE‐EPI) and T2 map derived from SE‐EPI. Assessment: Placental size on HASTE sequences and T2 mapping‐based histogram features were extracted. Three radiologists qualitatively evaluated the visibility of maternal cotyledon on HASTE and SE‐EPI sequences with echo times (TEs) = 60, 90, and 120 msec using 3‐point Likert scales: 0, absent; 1, equivocal; and 2, present. Statistical Tests: Welch's t‐test or Mann–Whitney U test for quantitative features between the favorable and unfavorable outcome groups. Areas under the receiver operating curves (AUCs) of the three readers' visual analyses to detect pregnancies with unfavorable outcomes. A P value of <0.05 was inferred as statistically significant. Results: Placental size (major and minor axis, estimated area of placental bed, and volume of placenta) and T2 mapping‐based histogram features (mean, skewness, and kurtosis) were statistically significantly different between the two groups. Visual analysis of HASTE and SE‐EPI with TE = 60 msec showed AUCs of 0.80–0.86 to detect pregnancies with unfavorable outcomes. Data Conclusion: Placental size, histogram features, and visual analysis of placental MRI may allow for risk stratification regarding outcomes among pregnancies diagnosed with FGR. Evidence Level: 3 Technical Efficacy: Stage 5 [ABSTRACT FROM AUTHOR]

Published
2022
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40. Linear IgA bullous dermatosis with desquamative gingivitis: A case report and literature review.

Author

Kashima, Kana, Morita, Yoshihiro, Suzuki, Mao, Kinosada, Hiroko, Matsumiya-Matsumoto, Yuka, Kato, Itsuro, Matsunaga, Kazuhide, and Uzawa, Narikazu

Abstract

Linear IgA bullous dermatosis (LAD) is a rare chronic autoimmune disorder. As oral mucosal involvement is particularly rare, it is difficult to make a definitive diagnosis based on the oral lesions. This disorder mainly causes blisters on the skin of the whole body and may cause erosions in the oral cavity. It is characterized by linear IgA deposition on the epithelial basement membrane. This report presents a case of a refractory oral mucosal lesion that led to the diagnosis and cure of linear IgA bullous dermatosis. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Pleomorphic Adenoma of the Salivary Glands and Epithelial–Mesenchymal Transition.

Author

Matsumiya-Matsumoto, Yuka, Morita, Yoshihiro, and Uzawa, Narikazu

Subjects
*PLEOMORPHIC adenoma, *EPITHELIAL-mesenchymal transition, *SALIVARY glands, *DNA repair, *EPITHELIAL cells
Abstract

Pleomorphic adenoma (PA) is a localized tumor that presents pleomorphic or mixed characteristics of epithelial origin and is interwoven with mucoid tissue, myxoid tissue, and chondroid masses. The literature reported that PA most often occurs in adults aged 30–60 years and is a female predilection; the exact etiology remains unclear. Epithelial–mesenchymal transition (EMT) is the transdifferentiation of stationary epithelial cells primarily activated by a core set of transcription factors (EMT-TFs) involved in DNA repair and offers advantages under various stress conditions. Data have suggested that EMTs represent the basic principle of tissue heterogeneity in PAs, demonstrating the potential of adult epithelial cells to transdifferentiate into mesenchymal cells. It has also been reported that multiple TFs, such as TWIST and SLUG, are involved in EMT in PA and that SLUG could play an essential role in the transition from myoepithelial to mesenchymal cells. Given this background, this review aims to summarize and clarify the involvement of EMT in the development of PA, chondrocyte differentiation, and malignant transformation to contribute to the fundamental elucidation of the mechanisms underlying EMT. [ABSTRACT FROM AUTHOR]

Published
2022
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46. CCN3 Expression Marks a Sulfomucin-nonproducing Unique Subset of Colonic Goblet Cells in Mice

Author

Akiyama, Shintaro, Mochizuki, Wakana, Nibe, Yoichi, Matsumoto, Yuka, Sakamoto, Kei, Oshima, Shigeru, Watanabe, Mamoru, and Nakamura, Tetsuya

Subjects
integumentary system, goblet cells, CCN3/Nov, Regular Article, in situ hybridization, digestive system, sulfomucin, digestive system diseases, DSS-induced colitis
Abstract

Intestinal goblet cells are characterized by their unique morphology and specialized function to secrete mucins. Although it is known that they are a heterogeneous population of cells, there have been few studies that relate the expression of a particular gene with functionally distinct subpopulations of intestinal goblet cells. Here we show that CCN3, a gene encoding a member of the CCN family proteins, is induced by inhibition of Notch signaling in colonic epithelial cells and expressed in goblet cells in mice. We demonstrate that CCN3 expression is confined to a subpopulation of goblet cells in the lower crypt of the proximal and middle colon. In addition, CCN3+ cells in the colon correlate well with the cells that are positive for alcian blue (AB) staining but negative for high-iron diamine (HID) staining in histology. We also show that CCN3+ cells, which are absent in the normal distal colon, transiently and ectopically emerge in regenerating crypts during the repair phase of DSS-induced colitis model. Our study thus suggests that CCN3 labels a unique subpopulation of sulfomucin-nonproducing colonic goblet cells that function in both normal and diseased colonic epithelia.

Published
2017

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