1. Autoimmune polyglandular syndrome type 3 variant in rheumatoid arthritis
- Author
-
Masami Ogasawara, Taro Horino, Osamu Ichii, and Yoshio Terada
- Subjects
medicine.medical_specialty ,graves’ disease (gd) ,endocrine system diseases ,030204 cardiovascular system & hematology ,type 2 diabetes mellitus (t2d) ,Gastroenterology ,Arthritis, Rheumatoid ,03 medical and health sciences ,0302 clinical medicine ,Antithyroid Agents ,Internal medicine ,Diabetes mellitus ,Adalimumab ,Humans ,Hypoglycemic Agents ,Insulin ,Medicine ,Rheumatoid factor ,rheumatoid arthritis (ra) ,Polyendocrinopathies, Autoimmune ,Aged ,Type 1 diabetes ,Methimazole ,business.industry ,Type 2 Diabetes Mellitus ,autoimmune polyglandular syndrome type 3 variant (aps3v) ,medicine.disease ,RC31-1245 ,Graves Disease ,Rheumatology ,Diabetes Mellitus, Type 1 ,Antirheumatic Agents ,Rheumatoid arthritis ,type 1 diabetes mellitus (t1d) ,Female ,030211 gastroenterology & hepatology ,Methotrexate ,autoimmune thyroid disease (aitd) ,business ,medicine.drug - Abstract
Introduction. Although type 1 diabetes mellitus is largely associated with autoimmune thyroid disease and this entity has been recently referred to as autoimmune polyglandular syndrome type 3 variant, the autoimmune polyglandular syndrome type 3 variant in patients with rheumatoid arthritis has not been reported so far. We herein describe the first case of rheumatoid arthritis that was associated with autoimmune polyglandular syndrome type 3 variant. Case report. A 77-year-old woman with a 15-year history of rheumatoid arthritis (RA) and a 10-year history of type 2 diabetes mellitus (T2D) presented with polyarthralgia and hyperglycaemia. Methotrexate 16 mg/week had been started from the onset and was continued, and adalimumab 40 mg/day was started for RA. Insulin treatment was also started for the diabetes. Laboratory examinations revealed high levels of C-reactive protein (CRP), rheumatoid factor, anti-cyclic citrullinated peptide antibody, and matrix metalloprotease 3. She was admitted multiple times as the symptoms recurred after treatment. Subsequently, based on the clinical course and investigations, she was diagnosed with type 1 diabetes mellitus and Graves’ disease occurring during the course of RA and T2D. Her clinical course improved after reinforcement of insulin therapy and the addition of thiamazole therapy. Conclusion. In patients with rheumatoid arthritis, the autoimmune polyglandular syndrome type 3 variant should be considered as the cause of the deterioration.
- Published
- 2020