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Isolated deep femoral artery aneurysms are rare and tend to be large at the time of diagnosis owing to their deep anatomic location. Deep femoral artery aneurysms are often complicated by rupture, with subsequent lower limb amputation. However, a large aneurysm can compress the surrounding deep femoral vein, leading to thrombosis. In the present report, we have described a rare surgical case of deep femoral artery aneurysm complicated by deep femoral vein thrombosis and pulmonary embolism. Preoperative inferior vena cava filter placement was effective for preventing perioperative worsening of the pulmonary embolism in this particular circumstance.