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5. Gender-related neuroanatomical differences in alcohol dependence: findings from the ENIGMA Addiction Working Group

Author

Rossetti, Maria Gloria, Patalay, Praveetha, Mackey, Scott, Allen, Nicholas B., Batalla, Albert, Bellani, Marcella, Chye, Yann, Cousijn, Janna, Goudriaan, Anna E., Hester, Robert, Hutchison, Kent, Li, Chiang-Shan R., Martin-Santos, Rocio, Momenan, Reza, Sinha, Rajita, Schmaal, Lianne, Sjoerds, Zsuzsika, Solowij, Nadia, Suo, Chao, van Holst, Ruth J., Veltman, Dick J., Yücel, Murat, Thompson, Paul M., Conrod, Patricia, Garavan, Hugh, Brambilla, Paolo, and Lorenzetti, Valentina

Published
2021
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6. Depression prevalence using the HADS-D compared to SCID major depression classification: An individual participant data meta-analysis

Author

Brehaut, Eliana, Neupane, Dipika, Levis, Brooke, Wu, Yin, Sun, Ying, Krishnan, Ankur, He, Chen, Bhandari, Parash Mani, Negeri, Zelalem, Riehm, Kira E., Rice, Danielle B., Azar, Marleine, Yan, Xin Wei, Imran, Mahrukh, Chiovitti, Matthew J., Saadat, Nazanin, Cuijpers, Pim, Ioannidis, John P.A., Markham, Sarah, Patten, Scott B., Ziegelstein, Roy C., Henry, Melissa, Ismail, Zahinoor, Loiselle, Carmen G., Mitchell, Nicholas D., Tonelli, Marcello, Boruff, Jill T., Kloda, Lorie A., Beraldi, Anna, Braeken, Anna P.B.M., Carter, Gregory, Clover, Kerrie, Conroy, Ronán M., Cukor, Daniel, da Rocha e Silva, Carlos E., De Souza, Jennifer, Downing, Marina G., Feinstein, Anthony, Ferentinos, Panagiotis P., Fischer, Felix H., Flint, Alastair J., Fujimori, Maiko, Gallagher, Pamela, Goebel, Simone, Jetté, Nathalie, Julião, Miguel, Keller, Monika, Kjærgaard, Marie, Love, Anthony W., Löwe, Bernd, Martin-Santos, Rocio, Michopoulos, Ioannis, Navines, Ricard, O’Rourke, Suzanne J., Öztürk, Ahmet, Pintor, Luis, Ponsford, Jennie L., Rooney, Alasdair G., Sánchez-González, Roberto, Schwarzbold, Marcelo L., Sharpe, Michael, Simard, Sébastien, Singer, Susanne, Stone, Jon, Tung, Ka-Yee, Turner, Alyna, Walker, Jane, Walterfang, Mark, White, Jennifer, Benedetti, Andrea, and Thombs, Brett D.

Published
2020
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7. Probability of major depression diagnostic classification based on the SCID, CIDI and MINI diagnostic interviews controlling for Hospital Anxiety and Depression Scale – Depression subscale scores: An individual participant data meta-analysis of 73 primary studies

Author

Wu, Yin, Levis, Brooke, Sun, Ying, Krishnan, Ankur, He, Chen, Riehm, Kira E., Rice, Danielle B., Azar, Marleine, Yan, Xin Wei, Neupane, Dipika, Bhandari, Parash Mani, Imran, Mahrukh, Chiovitti, Matthew J., Saadat, Nazanin, Boruff, Jill T., Cuijpers, Pim, Gilbody, Simon, McMillan, Dean, Ioannidis, John P.A., Kloda, Lorie A., Patten, Scott B., Shrier, Ian, Ziegelstein, Roy C., Henry, Melissa, Ismail, Zahinoor, Loiselle, Carmen G., Mitchell, Nicholas D., Tonelli, Marcello, Al-Adawi, Samir, Beraldi, Anna, Braeken, Anna P.B.M., Büel-Drabe, Natalie, Bunevicius, Adomas, Carter, Gregory, Chen, Chih-Ken, Cheung, Gary, Clover, Kerrie, Conroy, Ronán M., Cukor, Daniel, da Rocha e Silva, Carlos E., Dabscheck, Eli, Daray, Federico M., Douven, Elles, Downing, Marina G., Feinstein, Anthony, Ferentinos, Panagiotis P., Fischer, Felix H., Flint, Alastair J., Fujimori, Maiko, Gallagher, Pamela, Gandy, Milena, Goebel, Simone, Grassi, Luigi, Härter, Martin, Jenewein, Josef, Jetté, Nathalie, Julião, Miguel, Kim, Jae-Min, Kim, Sung-Wan, Kjærgaard, Marie, Köhler, Sebastian, Loosman, Wim L., Löwe, Bernd, Martin-Santos, Rocio, Massardo, Loreto, Matsuoka, Yutaka, Mehnert, Anja, Michopoulos, Ioannis, Misery, Laurent, Navines, Ricard, O'Donnell, Meaghan L., Öztürk, Ahmet, Peceliuniene, Jurate, Pintor, Luis, Ponsford, Jennie L., Quinn, Terence J., Reme, Silje E., Reuter, Katrin, Rooney, Alasdair G., Sánchez-González, Roberto, Schwarzbold, Marcelo L., Senturk Cankorur, Vesile, Shaaban, Juwita, Sharpe, Louise, Sharpe, Michael, Simard, Sébastien, Singer, Susanne, Stafford, Lesley, Stone, Jon, Sultan, Serge, Teixeira, Antonio L., Tiringer, Istvan, Turner, Alyna, Walker, Jane, Walterfang, Mark, Wang, Liang-Jen, White, Jennifer, Wong, Dana K., Benedetti, Andrea, and Thombs, Brett D.

Published
2020
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14. Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group

Author

Rossetti, Maria Gloria, Mackey, Scott, Patalay, Praveetha, Allen, Nicholas B., Batalla, Albert, Bellani, Marcella, Chye, Yann, Conrod, Patricia, Cousijn, Janna, Garavan, Hugh, Goudriaan, Anna E., Hester, Robert, Martin-Santos, Rocio, Solowij, Nadia, Suo, Chao, Thompson, Paul M., Yücel, Murat, Brambilla, Paolo, and Lorenzetti, Valentina

Published
2021
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15. Sex differences in the neuroanatomy of alcohol dependence: hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group

Author

Grace, Sally, Rossetti, Maria Gloria, Allen, Nicholas, Batalla, Albert, Bellani, Marcella, Brambilla, Paolo, Chye, Yann, Cousijn, Janna, Goudriaan, Anna E, Hester, Robert, Hutchison, Kent, Labuschagne, Izelle, Momenan, Reza, Martin-Santos, Rocio, Rendell, Peter, Solowij, Nadia, Sinha, Rajita, Li, Chiang-shan Ray, Schmaal, Lianne, Sjoerds, Zsuzsika, Suo, Chao, Terrett, Gill, van Holst, Ruth J., Veltman, Dick J., Yücel, Murat, Thompson, Paul, Conrod, Patricia, Mackey, Scott, Garavan, Hugh, and Lorenzetti, Valentina

Published
2021
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19. Burnout in residents during the first wave of the COVID-19 pandemic: a systematic review and meta-analysis.

Author

Navinés, Ricard, Olive, Victoria, Hidalgo-Mazzei, Diego, Langohr, Klaus, Vieta, Eduard, and Martin-Santos, Rocio

Subjects
COVID-19 pandemic, PSYCHOLOGICAL burnout, COVID-19, STATUS (Law)
Abstract

Introduction: The high prevalence of burnout in resident physicians is expected to have increased as a result of the expansion of the pandemic. We conducted a systematic review with a meta-analysis of studies conducted during the first wave of the COVID-19 pandemic on burnout in residents and potential associated risk factors. Methods: The search was done in the Web of Science, MEDLINE, Scopus, and Lillac databases (April 2020--October 2021) using a priori protocol based on the PRISMA guidelines. The Newcastle Ottawa Scale was used to assess the risk of bias in the included studies. We estimated the pooled prevalence (95% CI) of burnout and the prevalence ratio (95% CI) of each risk factor associated. Results: We included 23 studies from 451 potential initial articles and those written in the English language; all of the collected studies were cross-sectional with anonymous online surveys, involving 4,998 responders (34%), of which 53.2% were female responders, 51% were R1-2, and 71% were in direct contact with COVID-19 patients. Eighty-seven percent presented a low-to-moderate risk of bias. Publication bias was not shown. The estimated pooled prevalence of burnout was 40% (95% CI = 0.26 -- 0.57). Burnout was associated with psychiatry history (PR = 4.60, 95% CI = 1.06 -- 20.06). There were no di erences by gender, civil status, children in-charge, year of residency, or time exposure to COVID-19. Discussion: The overall prevalence of burnout in residents during the first wave of the pandemic was in line with the results described in this collective before the pandemic. The presence of a psychiatry history was a potential burnout risk factor, suggesting a high vulnerability during the peak of the stress period and the need to implement mental health surveillance for this subgroup. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Brain volumes in alcohol use disorder : Do females and males differ? A whole-brain magnetic resonance imaging mega-analysis

Author

Maggioni, Eleonora, Rossetti, Maria G, Allen, Nicholas B, Batalla, Albert, Bellani, Marcella, Chye, Yann, Cousijn, Janna, Goudriaan, Anna E, Hester, Robert, Hutchison, Kent, Chiang-Shan R, Li, Martin-Santos, Rocio, Momenan, Reza, Sinha, Rajita, Schmaal, Lianne, Solowij, Nadia, Suo, Chao, van Holst, Ruth J, Veltman, Dick J, Yücel, Murat, Thompson, Paul M, Conrod, Patricia, Mackey, Scott, Garavan, Hugh, Brambilla, Paolo, and Lorenzetti, Valentina

Subjects
alcohol use disorders, alcohol dependence, sex, voxel-based morphometry, MRI
Abstract

Emerging evidence suggests distinct neurobiological correlates of alcohol use disorder (AUD) between sexes, which however remain largely unexplored. This work from ENIGMA Addiction Working Group aimed to characterize the sex differences in gray matter (GM) and white matter (WM) correlates of AUD using a whole-brain, voxelbased, multi-tissue mega-analytic approach, thereby extending our recent surfacebased region of interest findings on a nearly matching sample using a complementary methodological approach. T1-weighted magnetic resonance imaging (MRI) data from 653 people with AUD and 326 controls was analyzed using voxel-based morphometry. The effects of group, sex, group-by-sex, and substance use severity in AUD on brain volumes were assessed using General Linear Models. Individuals with AUD relative to controls had lower GM volume in striatal, thalamic, cerebellar, and widespread cortical clusters. Group-by-sex effects were found in cerebellar GM and WM volumes, which were more affected by AUD in females than males. Smaller groupby- sex effects were also found in frontotemporal WM tracts, which were more affected in AUD females, and in temporo-occipital and midcingulate GM volumes, which were more affected in AUD males. AUD females but not males showed a negative association between monthly drinks and precentral GM volume. Our results suggest that AUD is associated with both shared and distinct widespread effects on GM and WM volumes in females and males. This evidence advances our previous region of interest knowledge, supporting the usefulness of adopting an exploratory perspective and the need to include sex as a relevant moderator variable in AUD.

Published
2023

25. Reproducibility in the absence of selective reporting : An illustration from large-scale brain asymmetry research

Author

Kong, Xiang-Zhen, Francks, Clyde, Allen, Nicholas B., Heslenfeld, Dirk, Hester, Robert, Hibar, Derrek Paul, Ho, Beng-Choon, Ho, Tiffany C., Hoekstra, Pieter J., Holst, Ruth J., Hoogman, Martine, Høvik, Marie F., Howells, Fleur M., Ames, David, Hugdahl, Kenneth, Huyser, Chaim, Ingvar, Martin, Ishikawa, Akari, James, Anthony, Jahanshad, Neda, Jernigan, Terry L., Jönsson, Erik G, Kaleda, Vasily, Kelly, Clare, Andreassen, Ole A., Kerich, Michael, Keshavan, Matcheri S., Khadka, Sabin, Kircher, Tilo, Kohls, Gregor, Konrad, Kerstin, Korucuoglu, Ozlem, Krämer, Bernd, Krug, Axel, Kuntsi, Jonna, Vasquez, Alejandro Arias, Kwon, Jun Soo, Lambregts-Rommelse, Nanda, Landén, Mikael, Lázaro, Luisa, Lebedeva, Irina, Lenroot, Rhoshel, Lesch, Klaus-Peter, Li, Qinqin, Lim, Kelvin O., Liu, Jia, Armstrong, Nicola J., Lochner, Christine, London, Edythe D., Lorenzetti, Valentina, Luciano, Michelle, Luijten, Maartje, Lundervold, Astri J., Mackey, Scott, MacMaster, Frank P., Maingault, Sophie, Malpas, Charles B., Asherson, Phil, Malt, Ulrik F., Mataix-Cols, David, Martin-Santos, Rocio, Mayer, Andrew R., McCarthy, Hazel, Medland, Sarah, Metha, Mitul, Mitchell, Philip B., Mueller, Bryon A., Maniega, Susana Muñoz, Bergo, Felipe, Mazoyer, Bernard, McDonald, Colm, McLellan, Quinn, McMahon, Katie L., McPhilemy, Genevieve, Momenan, Reza, Morales, Angelica M., Narayanaswamy, Janardhanan C., Moreira, José Carlos Vasques, Nerland, Stener, Bastin, Mark E., Nestor, Liam, Newman, Erik, Nigg, Joel T., Nordvik, Jan Egil, Novotny, Stephanie, Weiss, Eileen Oberwelland, O'Gorman, Ruth L., Oosterlaan, Jaap, Oranje, Bob, Orr, Catherine, Batalla, Albert, Overs, Bronwyn, Paloyelis, Yannis, Pauli, Paul, Paulus, Martin, Plessen, Kerstin Jessica, Polier, Georg G., Pomarol-Clotet, Edith, Portella, Maria J., Qiu, Jiang, Radua, Joaquim, Bauer, Jochen, Ramos-Quiroga, Josep Antoni, Reddy, Y. C. Janardhan, Reif, Andreas, Roberts, Gloria, Rosa, Pedro, Rubia, Katya, Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Schmaal, Lianne, Baune, Bernhard T, Schulte-Rüther, Martin, Schweren, Lizanne, Seitz, Jochen, Serpa, Mauricio Henriques, Shaw, Philip, Shumskaya, Elena, Silk, Timothy J., Simmons, Alan N., Simulionyte, Egle, Sinha, Rajita, Baur-Streubel, Ramona, Sjoerds, Zsuzsika, Smelror, Runar Elle, Soliva, Joan Carlos, Solowij, Nadia, Souza-Duran, Fabio Luisde, Sponheim, Scott R., Stein, Dan J., Stein, Elliot A., Stevens, Michael, Strike, Lachlan T., Biederman, Joseph, Sudre, Gustavo, Sui, Jing, Tamm, Leanne, Temmingh, Hendrik S., Thoma, Robert J., Tomyshev, Alexander, Tronchin, Giulia, Turner, Jessica, Uhlmann, Anne, Erp, Theo G. M., Blaine, Sara K., Heuvel, Odile A., Meer, Dennis, Eijk, Liza, Vance, Alasdair, Veer, Ilya M., Veltman, Dick J., Venkatasubramanian, Ganesan, Vilarroya, Oscar, Vives-Gilabert, Yolanda, Voineskos, Aristotle N, Boedhoe, Premika, Völzke, Henry, Vuletic, Daniella, Walitza, Susanne, Walter, Henrik, Walton, Esther, Wardlaw, Joanna M., Wen, Wei, Westlye, Lars T., Whelan, Christopher D., White, Tonya, Bøen, Erlend, Wiers, Reinout W., Wright, Margaret J., Wittfeld, Katharina, Yang, Tony T., Yasuda, Clarissa L., Yoncheva, Yuliya, Yücel, Murat, Yun, Je-Yeon, Zanetti, Marcus Vinicius, Zhen, Zonglei, Bose, Anushree, Zhu, Xing-xing, Ziegler, Georg C., Zubicaray, Greig I., Zwiers, Marcel, Project, Karolinska Schizophrenia, Glahn, David C., Crivello, Fabrice, Fisher, Simon E., Thompson, Paul M., Bralten, Janita, Farde, Lars, Flyckt, Lena, Engberg, Göran, Erhardt, Sophie, Fatouros-Bergman, Helena, Cervenka, Simon, Schwieler, Lilly, Piehl, Fredrik, Agartz, Ingrid, Collste, Karin, Brandeis, Daniel, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Sellgren, Carl, Brem, Silvia, Mathias, Samuel R., Brodaty, Henry, Yüksel, Dilara, Brooks, Samantha J., Buitelaar, Jan, Bürger, Christian, Bülow, Robin, Calhoun, Vince, Calvo, Anna, Canales-Rodríguez, Erick Jorge, Cannon, Dara M., Guadalupe, Tulio, Caparelli, Elisabeth C., Castellanos, Francisco X., Cendes, Fernando, Chaim-Avancini, Tiffany Moukbel, Chantiluke, Kaylita, Chen, Qun-lin, Chen, Xiayu, Cheng, Yuqi, Christakou, Anastasia, Clark, Vincent P., Abé, Christoph, Coghill, David, Connolly, Colm G., Conzelmann, Annette, Córdova-Palomera, Aldo, Cousijn, Janna, Crow, Tim, Cubillo, Ana, Dannlowski, Udo, Bruttopilo, Sara Ambrosino, Zeeuw, Patrick, Deary, Ian J., Demeter, Damion V., Di Martino, Adriana, Dickie, Erin W, Dietsche, Bruno, Doan, Nhat Trung, Doherty, Colin P., Doyle, Alysa, Durston, Sarah, Earl, Eric, Akudjedu, Theophilus N., Ehrlich, Stefan, Ekman, Carl Johan, Elvsåshagen, Torbjørn, Epstein, Jeffery N., Fair, Damien A., Faraone, Stephen V., Fernández, Guillén, Flint, Claas, Filho, Geraldo Busatto, Förster, Katharina, Aleman, Andre, Fouche, Jean-Paul, Foxe, John J., Frodl, Thomas, Fuentes-Claramonte, Paola, Fullerton, Janice M., Garavan, Hugh, Santos Garcia, Danielle, Gotlib, Ian H., Goudriaan, Anna E., Grabe, Hans Jörgen, Alhusaini, Saud, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gurholt, Tiril, Haavik, Jan, Hahn, Tim, Hansell, Narelle K., Harris, Mathew A., Hartman, Catharina A., Carmen Valdés Hernández, Maria, Alhusaini, Saud, Del Carmen Valdés Hernández, Maria, Heslenfeld, Dirk, Hester, Robert, Hibar, Derrek Paul, Ho, Beng-Choon, Ho, Tiffany C., Hoekstra, Pieter J., van Holst, Ruth J., Hoogman, Martine, Høvik, Marie F., Allen, Nicholas B., Howells, Fleur M., Hugdahl, Kenneth, Huyser, Chaim, Ingvar, Martin, Ishikawa, Akari, James, Anthony, Jahanshad, Neda, Jernigan, Terry L., Jönsson, Erik G., Kaleda, Vasily, Ames, David, Kelly, Clare, Kerich, Michael, Keshavan, Matcheri S., Khadka, Sabin, Kircher, Tilo, Kohls, Gregor, Konrad, Kerstin, Korucuoglu, Ozlem, Krämer, Bernd, Krug, Axel, Andreassen, Ole A., Kuntsi, Jonna, Kwon, Jun Soo, Lambregts-Rommelse, Nanda, Landén, Mikael, Lázaro, Luisa, Lebedeva, Irina, Lenroot, Rhoshel, Lesch, Klaus-Peter, Li, Qinqin, Lim, Kelvin O., Vasquez, Alejandro Arias, Liu, Jia, Lochner, Christine, London, Edythe D., Lorenzetti, Valentina, Luciano, Michelle, Luijten, Maartje, Lundervold, Astri J., Mackey, Scott, MacMaster, Frank P., Maingault, Sophie, Armstrong, Nicola J., Malpas, Charles B., Malt, Ulrik F., Mataix-Cols, David, Martin-Santos, Rocio, Mayer, Andrew R., McCarthy, Hazel, Medland, Sarah, Metha, Mitul, Mitchell, Philip B., Mueller, Bryon A., Asherson, Phil, Maniega, Susana Muñoz, Mazoyer, Bernard, McDonald, Colm, McLellan, Quinn, McMahon, Katie L., McPhilemy, Genevieve, Momenan, Reza, Morales, Angelica M., Narayanaswamy, Janardhanan C., Moreira, José Carlos Vasques, Bergo, Felipe, Nerland, Stener, Nestor, Liam, Newman, Erik, Nigg, Joel T., Nordvik, Jan Egil, Novotny, Stephanie, Weiss, Eileen Oberwelland, O'Gorman, Ruth L., Oosterlaan, Jaap, Oranje, Bob, Bastin, Mark E., Orr, Catherine, Overs, Bronwyn, Paloyelis, Yannis, Pauli, Paul, Paulus, Martin, Plessen, Kerstin Jessica, von Polier, Georg G., Pomarol-Clotet, Edith, Portella, Maria J., Qiu, Jiang, Batalla, Albert, Radua, Joaquim, Ramos-Quiroga, Josep Antoni, Reddy, Y. C. Janardhan, Reif, Andreas, Roberts, Gloria, Rosa, Pedro, Rubia, Katya, Sacchet, Matthew D., Sachdev, Perminder S., Salvador, Raymond, Bauer, Jochen, Schmaal, Lianne, Schulte-Rüther, Martin, Schweren, Lizanne, Seitz, Jochen, Serpa, Mauricio Henriques, Shaw, Philip, Shumskaya, Elena, Silk, Timothy J., Simmons, Alan N., Simulionyte, Egle, Baune, Bernhard T., Sinha, Rajita, Sjoerds, Zsuzsika, Smelror, Runar Elle, Soliva, Joan Carlos, Solowij, Nadia, Souza-Duran, Fabio Luisde, Sponheim, Scott R., Stein, Dan J., Stein, Elliot A., Stevens, Michael, Baur-Streubel, Ramona, Strike, Lachlan T., Sudre, Gustavo, Sui, Jing, Tamm, Leanne, Temmingh, Hendrik S., Thoma, Robert J., Tomyshev, Alexander, Tronchin, Giulia, Turner, Jessica, Uhlmann, Anne, Biederman, Joseph, van Erp, Theo G. M., van den Heuvel, Odile A., van der Meer, Dennis, van Eijk, Liza, Vance, Alasdair, Veer, Ilya M., Veltman, Dick J., Venkatasubramanian, Ganesan, Vilarroya, Oscar, Vives-Gilabert, Yolanda, Blaine, Sara K., Voineskos, Aristotle N., Völzke, Henry, Vuletic, Daniella, Walitza, Susanne, Walter, Henrik, Walton, Esther, Wardlaw, Joanna M., Wen, Wei, Westlye, Lars T., Whelan, Christopher D., Boedhoe, Premika, White, Tonya, Wiers, Reinout W., Wright, Margaret J., Wittfeld, Katharina, Yang, Tony T., Yasuda, Clarissa L., Yoncheva, Yuliya, Yücel, Murat, Yun, Je-Yeon, Zanetti, Marcus Vinicius, Bøen, Erlend, Zhen, Zonglei, Zhu, Xing-Xing, Ziegler, Georg C., de Zubicaray, Greig I., Zwiers, Marcel, Project, Karolinska Schizophrenia, Glahn, David C., Crivello, Fabrice, Fisher, Simon E., Thompson, Paul M., Bose, Anushree, Francks, Clyde, Farde, Lars, Flyckt, Lena, Engberg, Göran, Erhardt, Sophie, Fatouros-Bergman, Helena, Cervenka, Simon, Schwieler, Lilly, Piehl, Fredrik, Agartz, Ingrid, Bralten, Janita, Collste, Karin, Victorsson, Pauliina, Malmqvist, Anna, Hedberg, Mikael, Orhan, Funda, Sellgren, Carl, Brandeis, Daniel, Kong, Xiang-Zhen, Brem, Silvia, Brodaty, Henry, Yüksel, Dilara, Brooks, Samantha J., Buitelaar, Jan, Bürger, Christian, Bülow, Robin, Calhoun, Vince, Calvo, Anna, Canales-Rodríguez, Erick Jorge, Mathias, Samuel R., Cannon, Dara M., Caparelli, Elisabeth C., Castellanos, Francisco X., Cendes, Fernando, Chaim-Avancini, Tiffany Moukbel, Chantiluke, Kaylita, Chen, Qun-Lin, Chen, Xiayu, Cheng, Yuqi, Christakou, Anastasia, Guadalupe, Tulio, Clark, Vincent P., Coghill, David, Connolly, Colm G., Conzelmann, Annette, Córdova-Palomera, Aldo, Cousijn, Janna, Crow, Tim, Cubillo, Ana, Dannlowski, Udo, de Bruttopilo, Sara Ambrosino, Abé, Christoph, de Zeeuw, Patrick, Deary, Ian J., Demeter, Damion V., Di Martino, Adriana, Dickie, Erin W., Dietsche, Bruno, Doan, Nhat Trung, Doherty, Colin P., Doyle, Alysa, Durston, Sarah, Earl, Eric, Ehrlich, Stefan, Ekman, Carl Johan, Elvsåshagen, Torbjørn, Epstein, Jeffery N., Fair, Damien A., Faraone, Stephen V., Fernández, Guillén, Flint, Claas, Filho, Geraldo Busatto, Akudjedu, Theophilus N., Förster, Katharina, Fouche, Jean-Paul, Foxe, John J., Frodl, Thomas, Fuentes-Claramonte, Paola, Fullerton, Janice M., Garavan, Hugh, do Santos Garcia, Danielle, Gotlib, Ian H., Goudriaan, Anna E., Aleman, Andre, Grabe, Hans Jörgen, Groenewold, Nynke A., Grotegerd, Dominik, Gruber, Oliver, Gurholt, Tiril, Haavik, Jan, Hahn, Tim, Hansell, Narelle K., Harris, Mathew A., Hartman, Catharina A., Ontwikkelingspsychologie (Psychologie, FMG), Adult Psychiatry, APH - Mental Health, ANS - Compulsivity, Impulsivity & Attention, Child and Adolescent Psychiatry & Psychosocial Care, Child Psychiatry, ANS - Cellular & Molecular Mechanisms, Laboratory Genetic Metabolic Diseases, Paediatrics, General Paediatrics, ARD - Amsterdam Reproduction and Development, Paediatric Pulmonology, Graduate School, and APH - Digital Health

Subjects
P‐hacking, Datasets as Topic, Publication bias, 0302 clinical medicine, 130 000 Cognitive Neurology & Memory, Statistics, team science, Brain asymmetry, Multicenter Studies as Topic, Cervell, Research Articles, Cerebral Cortex, Radiological and Ultrasound Technology, P-hacking, 05 social sciences, Brain, Cerebral cortex, Middle Aged, Magnetic Resonance Imaging, Discoveries in science, Escorça cerebral, Neurology, Biaix de publicació, Anatomy, Psychology, Research Article, Neuroinformatics, Adult, Adolescent, Neuroimaging, Descobriments científics, 050105 experimental psychology, Statistical power, 03 medical and health sciences, Young Adult, Magnetic resonance imaging, Imatges per ressonància magnètica, multisite collaboration, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, ddc:610, reproducibility, Aged, publication bias, Reproducibility, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Perspective (graphical), Reproducibility of Results, Brain Cortical Thickness, Research data, Sample size determination, Dades de recerca, Neurology (clinical), Scale (map), Developmental Psychopathology, 030217 neurology & neurosurgery
Abstract

The problem of poor reproducibility of scientific findings has received much attention over recent years, in a variety of fields including psychology and neuroscience. The problem has been partly attributed to publication bias and unwanted practices such as p‐hacking. Low statistical power in individual studies is also understood to be an important factor. In a recent multisite collaborative study, we mapped brain anatomical left–right asymmetries for regional measures of surface area and cortical thickness, in 99 MRI datasets from around the world, for a total of over 17,000 participants. In the present study, we revisited these hemispheric effects from the perspective of reproducibility. Within each dataset, we considered that an effect had been reproduced when it matched the meta‐analytic effect from the 98 other datasets, in terms of effect direction and significance threshold. In this sense, the results within each dataset were viewed as coming from separate studies in an “ideal publishing environment,” that is, free from selective reporting and p hacking. We found an average reproducibility rate of 63.2% (SD = 22.9%, min = 22.2%, max = 97.0%). As expected, reproducibility was higher for larger effects and in larger datasets. Reproducibility was not obviously related to the age of participants, scanner field strength, FreeSurfer software version, cortical regional measurement reliability, or regional size. These findings constitute an empirical illustration of reproducibility in the absence of publication bias or p hacking, when assessing realistic biological effects in heterogeneous neuroscience data, and given typically‐used sample sizes., Region‐wise effect sizes and reproducibility rates of hemispheric asymmetry effects. In general, effects with higher effect sizes showed higher reproducibility, given the same conditions (e.g., sample size and data heterogeneity).

Published
2022
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27. Facial emotion processing in patients with social anxiety disorder and Williams-Beuren syndrome: an fMRI study

Author

Binelli, Cynthia, Muniz, Armando, Subira, Susana, Navines, Ricard, Blanco- Hinojo, Laura, Perez-Garcia, Debora, Crippa, Jose, Farre, Magi, Perez-Jurado, Luis, Pujol, Jesus, and Martin-Santos, Rocio

Subjects
Facial expression -- Health aspects, Social phobia -- Genetic aspects -- Physiological aspects, Magnetic resonance imaging -- Methods, Williams syndrome -- Genetic aspects -- Physiological aspects, Health, Psychology and mental health
Abstract

Background: Social anxiety disorder (SAD) and Williams-Beuren syndrome (WBS) are 2 conditions with major differences in terms of genetics, development and cognitive profiles. Both conditions are associated with compromised abilities in overlapping areas, including social approach, processing of social emotional cues and gaze behaviour, and to some extent they are associated with opposite behaviours in these domains. We examined common and distinct patterns of brain activation during a facial emotion processing paradigm in patients with SAD and WBS. Methods: We examined patients with SAD and WBS and healthy controls matched by age and laterality using functional MRI during the processing of happy, fearful and angry faces. Results: We included 20 patients with SAD and 20 with WBS as well as 20 matched controls in our study. Patients with SAD and WBS did not differ in the pattern of limbic activation. We observed differences in early visual areas of the face processing network in patients with WBS and differences in the cortical prefrontal regions involved in the top-down regulation of anxiety and in the fusiform gyrus for patients with SAD. Compared with those in the SAD and control groups, participants in the WBS group did not activate the right lateral inferior occipital cortex. In addition, compared with controls, patients with WBS hypoactivated the posterior primary visual cortex and showed significantly less deactivation in the right temporal operculum. Participants in the SAD group showed decreased prefrontal activation compared with those in the WBS and control groups. In addition, compared with controls, participants with SAD showed decreased fusiform activation. Participants with SAD and WBS also differed in the pattern of activation in the superior temporal gyrus, a region that has been linked to gaze processing. Limitations: The results observed in the WBS group are limited by the IQ of the WBS sample; however, the specificity of findings suggests that the pattern of brain activation observed for WBS is more likely to reflect a neurobiological substrate rather than intellectual impairment per se. Conclusion: Patients with SAD and WBS showed common and specific patterns of brain activation. Our results highlight the role of cortical regions during facial emotion processing in individuals with SAD and WBS., Introduction Social anxiety disorder (SAD) is a highly prevalent psychiatric condition. (1) The core feature of the disorder is a marked and persistent fear of social situations in which the [...]

Published
2016
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29. A multidisciplinary support programme increases the efficiency of pegylated interferon alfa-2a and ribavirin in hepatitis C

Author

Carrión, José Antonio, Gonzalez-Colominas, Elena, García-Retortillo, Montserrat, Cañete, Nuria, Cirera, Isabel, Coll, Susanna, Giménez, Maria Dolors, Márquez, Carmen, Martin-Escudero, Victoria, Castellví, Pere, Navinés, Ricard, Castaño, Juan Ramon, Galeras, Josep Anton, Salas, Esther, Bory, Felipe, Martín-Santos, Rocío, and Solà, Ricard

Published
2013
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33. Brain structural covariance network differences in adults with alcohol dependence and heavy-drinking adolescents

Author

Albaugh, Matthew D., Cao, Zhipeng, Cupertino, Renata B., Schwab, Nathan, Spechler, Phillip A., Allen, Nicholas, Artiges, Eric, Banaschewski, Tobias, Bokde, Arun L. W., Burke Quinlan, Erin, Orr, Catherine, Cousijn, Janna, Flor, Herta, Foxe, John J., Goudriaan, Anna E., Gowland, Penny, Grigis, Antoine, Heinz, Andreas, Hester, Robert, Hutchison, Kent, Li, Chiang?Shan R., London, Edythe D., Lorenzetti, Valentina, Luijten, Maartje, Nees, Frauke, Martin?Santos, Rocio, Martinot, Jean?Luc, Millenet, Sabina, Momenan, Reza, Papadopoulos Orfanos, Dimitri, Paulus, Martin P., Poustka, Luise, Schmaal, Lianne, Schumann, Gunter, Sinha, Rajita, Smolka, Michael N., Solowij, Nadia, Stein, Dan J., Stein, Elliot A., Uhlmann, Anne, Holst, Ruth J., Veltman, Dick J., Walter, Henrik, Whelan, Robert, Wiers, Reinout W., Zhang, Sheng, Jahanshad, Neda, Thompson, Paul M., Conrod, Patricia, Mackey, Scott, and Garavan, Hugh

Subjects
Psychiatry and Mental health, Sir Peter Mansfield Imaging Centre (SPMIC), Medicine (miscellaneous)
Abstract

BACKGROUND AND AIMS: Graph theoretic analysis of structural covariance networks (SCN) provides an assessment of brain organization that has not yet been applied to alcohol dependence (AD). We estimated whether SCN differences are present in adults with AD and heavy-drinking adolescents at age 19 and age 14, prior to substantial exposure to alcohol. DESIGN: Cross-sectional sample of adults and a cohort of adolescents. Correlation matrices for cortical thicknesses across 68 regions were summarized with graph theoretic metrics. SETTING AND PARTICIPANTS: A total of 745 adults with AD and 979 non-dependent controls from 24 sites curated by the Enhancing NeuroImaging Genetics through Meta Analysis (ENIGMA)-Addiction consortium, and 297 hazardous drinking adolescents and 594 controls at ages 19 and 14 from the IMAGEN study, all from Europe. MEASUREMENTS: Metrics of network segregation (modularity, clustering coefficient and local efficiency) and integration (average shortest path length and global efficiency). FINDINGS: The younger AD adults had lower network segregation and higher integration relative to non-dependent controls. Compared with controls, the hazardous drinkers at age 19 showed lower modularity [area-under-the-curve (AUC) difference?=?-0.0142, 95% confidence interval (CI)?=?-0.1333, 0.0092; P-value?=?0.017], clustering coefficient (AUC difference?=?-0.0164, 95% CI?=?-0.1456, 0.0043; P-value?=?0.008) and local efficiency (AUC difference?=?-0.0141, 95% CI?=?-0.0097, 0.0034; P-value?=?0.010), as well as lower average shortest path length (AUC difference?=?-0.0405, 95% CI?=?-0.0392, 0.0096; P-value?=?0.021) and higher global efficiency (AUC difference?=?0.0044, 95% CI?=?-0.0011, 0.0043; P-value?=?0.023). The same pattern was present at age 14 with lower clustering coefficient (AUC difference?=?-0.0131, 95% CI?=?-0.1304, 0.0033; P-value?=?0.024), lower average shortest path length (AUC difference?=?-0.0362, 95% CI?=?-0.0334, 0.0118; P-value?=?0.019) and higher global efficiency (AUC difference?=?0.0035, 95% CI?=?-0.0011, 0.0038; P-value?=?0.048). CONCLUSIONS: Cross-sectional analyses indicate that a specific structural covariance network profile is an early marker of alcohol dependence in adults. Similar effects in a cohort of heavy-drinking adolescents, observed at age 19 and prior to substantial alcohol exposure at age 14, suggest that this pattern may be a pre-existing risk factor for problematic drinking.

Published
2022

47. Association study of 44 candidate genes with depressive and anxiety symptoms in post-partum women

Author

Costas, Javier, Gratacòs, Mònica, Escaramís, Geòrgia, Martín-Santos, Rocío, de Diego, Yolanda, Baca-García, Enrique, Canellas, Francesca, Estivill, Xavier, Guillamat, Roser, Guitart, Miriam, Gutiérrez-Zotes, Alfonso, García-Esteve, Luisa, Mayoral, Fermín, Dolores Moltó, María, Phillips, Christopher, Roca, Miquel, Carracedo, Ángel, Vilella, Elisabet, and Sanjuán, Julio

Published
2010
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48. Assessment of the Neuropeptide S System in Anxiety Disorders

Author

Donner, Jonas, Haapakoski, Rita, Ezer, Sini, Melén, Erik, Pirkola, Sami, Gratacòs, Mònica, Zucchelli, Marco, Anedda, Francesca, Johansson, Lovisa E., Söderhäll, Cilla, Orsmark-Pietras, Christina, Suvisaari, Jaana, Martín-Santos, Rocío, Torrens, Marta, Silander, Kaisa, Terwilliger, Joseph D., Wickman, Magnus, Pershagen, Göran, Lönnqvist, Jouko, Peltonen, Leena, Estivill, Xavier, D'Amato, Mauro, Kere, Juha, Alenius, Harri, and Hovatta, Iiris

Published
2010
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