Search

We study the impact of black hole nuclear activity on both the global and radial star formation rate (SFR) profiles in X-ray-selected active galactic nuclei (AGN) in the field of miniJPAS, the precursor of the much wider J-PAS project. Our sample includes 32 AGN with z < 0.3 detected via the XMM-Newton and Chandra surveys. For comparison, we assembled a control sample of 71 star-forming (SF) galaxies with similar magnitudes, sizes, and redshifts. To derive the global properties of both the AGN and the control SF sample, we used CIGALE to fit the spectral energy distributions derived from the 56 narrowband and 4 broadband filters from miniJPAS. We find that AGN tend to reside in more massive galaxies than their SF counterparts. After matching samples based on stellar mass and comparing their SFRs and specific SFRs (sSFRs), no significant differences appear. This suggests that the presence of AGN does not strongly influence overall star formation. However, when we used miniJPAS as an integral field unit (IFU) to dissect galaxies along their position angle, a different picture emerges. We find that AGN tend to be more centrally concentrated in mass with respect to SF galaxies. Moreover, we find a suppression of the sSFR up to 1Re and then an enhancement beyond 1Re, strongly contrasting with the decreasing radial profile of sSFRs in SF galaxies. This could point to an inside-out quenching of AGN host galaxies. Additionally, we examined how the radial profiles of the sSFRs in AGN and SF galaxies depend on galaxy morphology, by dividing our sample into disk-dominated (DD), pseudo-bulge (PB), and bulge-dominated (BD) systems. In DD systems, AGN exhibit a flat sSFR profile in the central regions and enhanced star formation beyond 1Re, contrasting with SF galaxies. In PB systems, SF galaxies show a decreasing sSFR profile, while AGN hosts exhibit an inside-out quenching scenario. In BD systems, both populations demonstrate consistent flat sSFR profiles. These findings suggest that the reason we do not see differences on a global scale is because star formation is suppressed in the central regions and enhanced in the outer regions of AGN host galaxies. While limited in terms of sample size, this work highlights the potential of the upcoming J-PAS as a wide-field low-resolution IFU for thousands of nearby galaxies and AGN. [ABSTRACT FROM AUTHOR]

Surgical treatment of high-grade spondylolisthesis is controversial and aims at restoring the spinopelvic sagittal balance through complete or partial reduction of the listhesis. Nerve decompression and interbody fusion are necessary for patients presenting with neurological deficit, severe pain, lower limb asymmetry, or deformities. We present the case and the results of a patient with high-grade spondylolisthesis, in whom minimally invasive management was performed. A narrative review in this topic is also provided. We performed a literature review of high-grade spondylolisthesis to compare our technique to current surgical alternatives. We included articles from PubMed, Embase, Scopus, Ovid, and Science Direct published between 1963 and 2022 that were written in English, German, and Spanish. The terms used were the following: "high grade spondylolisthesis," "spondyloptosis," "surgical management," "interbody fusion," and "arthrodesis." In all, 485 articles were displayed, from which we filtered 112 by title and abstract. At the end, 75 references were selected for the review. Different interbody fusion techniques can be used to correct the lumbosacral kyphosis and restore the spinopelvic parameters. A complete reduction of the listhesis is not always required. The surgical procedure carried out in our patient corresponds to the first known case of minimally invasive circumferential arthrodesis with iliac screws and sacral fixation in a high-grade dysplastic spondylolisthesis. This approach guarantees the correction of the lumbosacral kyphosis and a complete reduction of the listhesis. Further studies are required to determine whether the results of this case can be extrapolated to other patients with high-grade spondylolisthesis. [ABSTRACT FROM AUTHOR]

The European eel Anguilla anguilla is a critically endangered catadromous species. There is an urgent need for close surveillance of the populations that are still viable in European rivers. The species is difficult to observe in freshwater because of its bottom-dwelling behavior; the currently employed methods of eel monitoring in Europe based on the physical capture of individuals are stressful and may cause mortality. Here, we present a new highly sensitive method based on an A. anguilla-specific qPCR marker designed within the cytochrome oxidase I mitochondrial gene for application on environmental DNA (eDNA). Since the detectability of eDNA depends on the hydrographic conditions, we applied correction for altitude and a linear model and were able to predict the eel biomass from the eDNA in the different rivers of northern Spain still holding wild populations. The method was validated by electrofishing surveys. This novel eDNA-based marker allows for estimating the European eel biomass in running waters from small 1.5 L water samples and could complement, or replace in some cases, current eel surveys without disturbing wild populations. [ABSTRACT FROM AUTHOR]

Background: Identification of cognitive impairment is based traditionally on the neuropsychological tests and biomarkers that are not available widely. This study aimed to establish the association between motor function (gait speed and handgrip strength) and cognitive performance in the Mini-Mental State Examination, globally and by domains. A secondary goal was calculating a cut-off point for gait speed and handgrip strength to classify older adults as cognitively impaired. Methods: This is a secondary analysis of SABE Colombia (Salud, Bienestar & Envejecimiento), a survey that was conducted in 2015 on health, wellbeing, and aging in Colombia. This study used linear regression models to search for an association between motor function and cognitive performance. The accuracy of motor function measurements in identifying cognitive impairment was assessed with receiver operating characteristic (ROC) curves. This study also analyzed other clinical and sociodemographical variables. Results: Gait speed was associated with orientation (r 2 = 0.16), language (r 2 = 0.15), recall memory (r 2 = 0.14), and counting (r 2 = 0.08). Similarly, handgrip strength was associated with orientation (r 2 = 0.175), language (r 2 = 0.164), recall memory (r 2 = 0.137), and counting (r 2 = 0.08). To differentiate older adults with and without cognitive impairment, a gait speed cut-off point of 0.59 m/s had an area under the curve (AUC) of 0.629 (0.613–0.646), and a weak handgrip (strength below 17.5 kg) had an AUC of 0.653 (0.645-0.661). The cut-off points for handgrip strength and gait speed were significantly higher in male participants. Conclusions: Gait speed and handgrip strength are similarly associated with the cognitive performance, exhibiting the most extensive association with orientation and language domains of the Mini-Mental State Examination. Gait speed and handgrip strength can easily be measured by any clinician, and they prove to be useful screening tools to detect cognitive impairment. [ABSTRACT FROM AUTHOR]

Single‐cell transcriptomics have revolutionized our understanding of the cell composition of tumors and allowed us to identify new subtypes of cells. Despite rapid technological advancements, single‐cell analysis remains resource‐intense hampering the scalability that is required to profile a sufficient number of samples for clinical associations. Therefore, more scalable approaches are needed to understand the contribution of individual cell types to the development and treatment response of solid tumors such as esophageal adenocarcinoma where comprehensive genomic studies have only led to a small number of targeted therapies. Due to the limited treatment options and late diagnosis, esophageal adenocarcinoma has a poor prognosis. Understanding the interaction between and dysfunction of individual cell populations provides an opportunity for the development of new interventions. In an attempt to address the technological and clinical needs, we developed a protocol for the separation of esophageal carcinoma tissue into leukocytes (CD45+), epithelial cells (EpCAM+), and fibroblasts (two out of PDGFRα, CD90, anti‐fibroblast) by fluorescence‐activated cell sorting and subsequent RNA sequencing. We confirm successful separation of the three cell populations by mapping their transcriptomic profiles to reference cell lineage expression data. Gene‐level analysis further supports the isolation of individual cell populations with high expression of CD3, CD4, CD8, CD19, and CD20 for leukocytes, CDH1 and MUC1 for epithelial cells, and FAP, SMA, COL1A1, and COL3A1 for fibroblasts. As a proof of concept, we profiled tumor samples of nine patients and explored expression differences in the three cell populations between tumor and normal tissue. Interestingly, we found that angiogenesis‐related genes were upregulated in fibroblasts isolated from tumors compared with normal tissue. Overall, we suggest our protocol as a complementary and more scalable approach compared with single‐cell RNA sequencing to investigate associations between clinical parameters and transcriptomic alterations of specific cell populations in esophageal adenocarcinoma. [ABSTRACT FROM AUTHOR]

We present deep optical and near-infrared (NIR) UBVRIHKs imaging data for 24 blue compact galaxies (BCGs). The individual exposure times are on average ∼40 min in the optical (B) and ∼90 min in the NIR, but on occasion up to ∼5 h for a single target and filter, observed with 2.5, 3.5, 8.2-m telescopes. The sample contains luminous dwarf and intermediate-mass BCGs which are predominantly metal poor, although a few have near-solar metallicities. We have analysed isophotal and elliptical integration surface brightness and colour profiles, extremely deep (μB ≲ 29 mag arcsec−2) contour maps and RGB images for each galaxy in the sample, and provide a morphological classification where such is missing. Separating the burst from the underlying host we find that regardless of the total luminosity the host galaxy has the properties of a low surface brightness (LSB) dwarf with MB ≳ −18. For a number of galaxies we discover a distinct LSB component dominant around and beyond the Holmberg radius. For the specific case of ESO 400−43A&B we detect an optical bridge between the two companion galaxies at the μV ∼ 28th mag arcsec−2 isophotal level. Synthetic disc tests are performed to verify that we can trace such faint components with negligible errors down to μB = 28 and μK = 23 mag arcsec−2. By examining the structural parameters (central surface brightness μ0 and scalelength hr) derived from two radial ranges typically assumed to be dominated by the underlying host galaxy, we demonstrate the importance of sampling the host well away from the effects of the burst. We find that μ0 and hr of the BCGs host deviate from those of dwarf ellipticals (dEs) and dwarf irregulars (dI) solely due to a strong burst contribution to the surface brightness profile almost down to the Holmberg radius. Structural parameters obtained from a fainter region, μB = 26–28 mag arcsec−2, are consistent with those of true LSB galaxies for the starbursting BCGs in our sample, and with dEs and dIs for the BCGs with less vigorous star formation. [ABSTRACT FROM AUTHOR]

This article presents a study which described the isolation and characterization of a ranavirus responsible for a systemic hemorrhagic disease in tadpoles of the common midwife toad Alytes obstetricians (CMT). It focuses on the virus that caused a mortality rate among tadpoles in the Picas de Europa National Park in Spain. The study shows the molecular characterization of the virus, including sequence analysis of the DNA polymerase and major capsid protein genes. A systemic distribution of the virus in diseased tadpoles is demonstrated, indicating that the isolated virus was the primary pathogen.

Background: Motoric Cognitive Risk Syndrome (MCR) is a predementia stage where slow gait speed and subjective memory complaints are present. The purpose of this study was to estimate the prevalence of MCR and assess its relationship with sociodemographic factors and chronic conditions., Methods: This is a secondary analysis of the SABE Colombia study conducted in 2015. The analytic sample consisted of 17·577 participants. After determining MCR prevalence, logistic regression was performed to examine the correlates of MCR., Findings: The prevalence of MCR was 10·71 %. The median age was 71 years and women composed 74·63 % of the MCR group. After adjusting for confounding variables MCR was associated with increasing age (OR 1·69, CI 1·43 - 1·92), no or low education (OR 1·99, CI 1·67- 2·37), MMSE (OR 0·93, CI 0·91 - 0·95) and chronic conditions such as mental disorders (OR 1·36, CI 1·11-1·67), history of myocardial infarction (OR 1·24, CI 1·04 - 1·47), hypertension (OR 1·23, CI 1·08 - 1·40) and diabetes (OR 1.18, CI 1.01 - 1.37)., Interpretation: This study found a prevalence of 10·71 % of MCR in Colombian older adults. Additionally, MCR was associated with chronic conditions and sociodemographic factors identified in prior studies. These results increase the awareness of a novel predementia stage whose identification can be performed by clinicians in the outpatient clinic, minimizing the cost of a full neuropsychologic evaluation performed in a memory clinic., Funding: Funded by the Administrative Department of Science, Technology and Innovation (Colciencias) and the Ministry of Health and Social Protection of Colombia., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict.

Introduction and Objective: Auditory steady state responses to continuous amplitude modulated tones at rates between 70 and 110Hz, have been proposed as a feasible alternative to objective frequency specific audiometry in cochlear implant subjects. The aim of the present study is to obtain physiological thresholds by means of auditory steady-state response in cochlear implant patients (Clarion HiRes 90K), with acoustic stimulation, on free field conditions and to verify its biological origin., Methods: 11 subjects comprised the sample. Four amplitude modulated tones of 500, 1000, 2000 and 4000Hz were used as stimuli, using the multiple frequency technique. The recording of auditory steady-state response was also recorded at 0dB HL of intensity, non-specific stimulus and using a masking technique., Results: The study enabled the electrophysiological thresholds to be obtained for each subject of the explored sample. There were no auditory steady-state responses at either 0dB or non-specific stimulus recordings. It was possible to obtain the masking thresholds. A difference was identified between behavioral and electrophysiological thresholds of -6±16, -2±13, 0±22 and -8±18dB at frequencies of 500, 1000, 2000 and 4000Hz respectively., Conclusions: The auditory steady state response seems to be a suitable technique to evaluate the hearing threshold in cochlear implant subjects., (Copyright © 2018 Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello. Publicado por Elsevier España, S.L.U. All rights reserved.)

Objective: We report three new cases of müllerianosis of the urinary bladder., Methods: We present three cases of women in the third decade of life, two of them presenting hematuria and pelvic pain, and the third was referred to perform a recto-vaginal endometriosis surgical procedure. Diagnosis was made by ultrasound and cystoscopy in the first and second case, and by CT scan in the endometriosis case., Results: Müllerianosis of the urinary bladder is described as the presence of müllerian remnants (endometrial, endosalpinx and endocervix) in the bladder wall. Diagnosis is made as a result of a pathologic study of the resected lesions. Although a relapse of the disease is infrequent, it can happen, and close monitoring of the patients must be performed., Conclusions: Müllerianosis of the bladder is a rare condition and differential diagnosis must be done with benign and malignant bladder lesions because it can affect the muscularis propia. It mostly presents as lower urinary tract symptoms and hematuria that can be cyclic. Transurethral resection is the treatment of choice in superficial and focal lesions. In the case of infiltration of the bladder muscle, and depending on the extension of the disease, partial cystectomy may be necessary.