10 results on '"Mark Janssen"'
Search Results
2. Neighborhood-scale air quality, public health, and equity implications of multi-modal vehicle electrification
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Maxime A Visa, Sara F Camilleri, Anastasia Montgomery, Jordan L Schnell, Mark Janssen, Zachariah E Adelman, Susan C Anenberg, Emily A Grubert, and Daniel E Horton
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electric vehicles ,transportation ,air quality ,public health ,air pollution ,environmental justice ,Environmental sciences ,GE1-350 - Abstract
Electric vehicles (EVs) constitute just a fraction of the current U.S. transportation fleet; however, EV market share is surging. EV adoption reduces on-road transportation greenhouse gas emissions by decoupling transportation services from petroleum, but impacts on air quality and public health depend on the nature and location of vehicle usage and electricity generation. Here, we use a regulatory-grade chemical transport model and a vehicle-to-electricity generation unit electricity assignment algorithm to characterize neighborhood-scale (∼1 km) air quality and public health benefits and tradeoffs associated with a multi-modal EV transition. We focus on a Chicago-centric regional domain wherein 30% of the on-road transportation fleet is instantaneously electrified and changes in on-road, refueling, and power plant emissions are considered. We find decreases in annual population-weighted domain mean NO _2 (−11.83%) and PM _2.5 (−2.46%) with concentration reductions of up to −5.1 ppb and −0.98 µ g m ^−3 in urban cores. Conversely, annual population-weighted domain mean maximum daily 8 h average ozone (MDA8O _3 ) concentrations increase +0.64%, with notable intra-urban changes of up to +2.3 ppb. Despite mixed pollutant concentration outcomes, we find overall positive public health outcomes, largely driven by NO _2 concentration reductions that result in outsized mortality rate reductions for people of color, particularly for the Black populations within our domain.
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- 2023
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3. Attractive running environments for all? A cross-sectional study on physical environmental characteristics and runners’ motives and attitudes, in relation to the experience of the running environment
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Ineke Deelen, Mark Janssen, Steven Vos, Carlijn B. M. Kamphuis, and Dick Ettema
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Running ,Experience ,Physical environment ,Motives and attitudes ,Attractive design ,Restorative capacity ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Running has become one of the most popular sports and has proven benefits for public health. Policy makers are increasingly aware that attractively designed public spaces may promote running. However, little is known about what makes a running environment attractive and restorative for runners and to what extent this depends on characteristics of the runner. This study aims to investigate 1) to what extent intrapersonal characteristics (i.e. motives and attitudes) and perceived environmental characteristics (e.g. quality of the running surface, greenness of the route, feelings of safety and hinderance by other road users) are associated with the perceived attractiveness and restorative capacity of the running environment and 2) to what extent the number of years of running experience modify these associations. Methods Cross-sectional data were collected through the online Eindhoven Running Survey 2015 (ERS15) among half marathon runners (N = 2477; response rate 26.6%). Linear regression analyses were performed for two outcomes separately (i.e. perceived attractiveness and perceived restorative capacity of the running environment) to investigate their relations with motives and attitudes, perceived environmental characteristics and interactions between perceived environmental characteristics and number of years of running experience. Results Perceived environmental characteristics, including green and lively routes and a comfortable running surface were more important for runners’ evaluation of the attractiveness and restorative capacity of the running environment than runners’ motives and attitudes. In contrast to experienced runners, perceived hinder from unleashed dogs and pedestrians positively impacted the attractiveness and restorative capacity for less experienced runners. Conclusions Perceived environmental characteristics were important determinants of the attractiveness and restorative capacity of the running environment for both novice and experienced runners. However, green and lively elements in the running environment and hinderances by cars were more important for less experienced runners. In order to keep novice runners involved in running it is recommended to design comfortable running tracks and routes and provide good access to attractive, green and lively spaces.
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- 2019
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4. How Do Runners Experience Personalization of Their Training Scheme: The Inspirun E-Coach?
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Mark Janssen, Jos Goudsmit, Coen Lauwerijssen, Aarnout Brombacher, Carine Lallemand, and Steven Vos
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personalization ,app ,e-coaching ,tailoring ,running ,training ,Chemical technology ,TP1-1185 - Abstract
Among runners, there is a high drop-out rate due to injuries and loss of motivation. These runners often lack personalized guidance and support. While there is much potential for sports apps to act as (e-)coaches to help these runners to avoid injuries, set goals, and maintain good intentions, most available running apps primarily focus on persuasive design features like monitoring, they offer few or no features that support personalized guidance (e.g., personalized training schemes). Therefore, we give a detailed description of the working mechanism of Inspirun e-Coach app and on how this app uses a personalized coaching approach with automatic adaptation of training schemes based on biofeedback and GPS-data. We also share insights into how end-users experience this working mechanism. The primary conclusion of this study is that the working mechanism (if provided with accurate data) automatically adapts training sessions to the runners’ physical workload and stimulates runners’ goal perception, motivation, and experienced personalization. With this mechanism, we attempted to make optimal use of the potential of wearable technology to support the large group of novice or less experienced runners and that by providing insight in our working mechanisms, it can be applied in other technologies, wearables, and types of sports.
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- 2020
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5. Who uses running apps and sports watches? Determinants and consumer profiles of event runners' usage of running-related smartphone applications and sports watches.
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Mark Janssen, Jeroen Scheerder, Erik Thibaut, Aarnout Brombacher, and Steven Vos
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Medicine ,Science - Abstract
Individual and unorganized sports with a health-related focus, such as recreational running, have grown extensively in the last decade. Consistent with this development, there has been an exponential increase in the availability and use of electronic monitoring devices such as smartphone applications (apps) and sports watches. These electronic devices could provide support and monitoring for unorganized runners, who have no access to professional trainers and coaches. The purpose of this paper is to gain insight into the characteristics of event runners who use running-related apps and sports watches. This knowledge is useful from research, design, and marketing perspectives to adequately address unorganized runners' needs, and to support them in healthy and sustainable running through personalized technology. Data used in this study are drawn from the standardized online Eindhoven Running Survey 2014 (ERS14). In total, 2,172 participants in the Half Marathon Eindhoven 2014 completed the questionnaire (a response rate of 40.0%). Binary logistic regressions were used to analyze the impact of socio-demographic variables, running-related variables, and psychographic characteristics on the use of running-related apps and sports watches. Next, consumer profiles were identified. The results indicate that the use of monitoring devices is affected by socio-demographics as well as sports-related and psychographic variables, and this relationship depends on the type of monitoring device. Therefore, distinctive consumer profiles have been developed to provide a tool for designers and manufacturers of electronic running-related devices to better target (unorganized) runners' needs through personalized and differentiated approaches. Apps are more likely to be used by younger, less experienced and involved runners. Hence, apps have the potential to target this group of novice, less trained, and unorganized runners. In contrast, sports watches are more likely to be used by a different group of runners, older and more experienced runners with higher involvement. Although apps and sports watches may potentially promote and stimulate sports participation, these electronic devices do require a more differentiated approach to target specific needs of runners. Considerable efforts in terms of personalization and tailoring have to be made to develop the full potential of these electronic devices as drivers for healthy and sustainable sports participation.
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- 2017
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6. Cause and Consequence of Tethering a SubTAD to Different Nuclear Compartments
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Mark Janssen, Patrick J. Wijchers, Hans Teunissen, Annette Denker, Carlo Vermeulen, Marjon J.A.M. Verstegen, Pernette J. Verschure, Christian Valdes-Quezada, Yun Zhu, Lisette C M Anink-Groenen, Geert Geeven, Peter H.L. Krijger, Wouter de Laat, Synthetic Systems Biology (SILS, FNWI), and Hubrecht Institute for Developmental Biology and Stem Cell Research
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0301 basic medicine ,Cis effect ,129 Strain ,Inbred C57BL ,Genome ,Chromosome segregation ,Mice ,Chromosome Segregation ,Lac Repressors ,Non-U.S. Gov't ,Cells, Cultured ,Genetics ,Regulation of gene expression ,Cultured ,biology ,Research Support, Non-U.S. Gov't ,Polycomb Repressive Complex 2 ,Nanog Homeobox Protein ,Chromatin ,Cell biology ,Histone ,medicine.anatomical_structure ,Lac Operon ,Mice, 129 Strain ,Cells ,Research Support ,Transfection ,Article ,03 medical and health sciences ,medicine ,Journal Article ,Animals ,Enhancer of Zeste Homolog 2 Protein ,Molecular Biology ,Embryonic Stem Cells ,Cell Nucleus ,Homeodomain Proteins ,Methyltransferases ,Cell Biology ,Chromatin Assembly and Disassembly ,Mice, Inbred C57BL ,Repressor Proteins ,Cell nucleus ,030104 developmental biology ,Gene Expression Regulation ,Genetic Loci ,biology.protein - Abstract
Summary Detailed genomic contact maps have revealed that chromosomes are structurally organized in megabase-sized topologically associated domains (TADs) that encompass smaller subTADs. These domains segregate in the nuclear space to form active and inactive nuclear compartments, but cause and consequence of compartmentalization are largely unknown. Here, we combined lacO/lacR binding platforms with allele-specific 4C technologies to track their precise position in the three-dimensional genome upon recruitment of NANOG, SUV39H1, or EZH2. We observed locked genomic loci resistant to spatial repositioning and unlocked loci that could be repositioned to different nuclear subcompartments with distinct chromatin signatures. Focal protein recruitment caused the entire subTAD, but not surrounding regions, to engage in new genomic contacts. Compartment switching was found uncoupled from transcription changes, and the enzymatic modification of histones per se was insufficient for repositioning. Collectively, this suggests that trans-associated factors influence three-dimensional compartmentalization independent of their cis effect on local chromatin composition and activity., Graphical Abstract, Highlights • 4C technology reveals nuclear repositioning of genomic loci upon protein recruitment • Given subTAD can adopt multiple nuclear positions depending on the recruited factor • Switching between nuclear compartments can be uncoupled from transcriptional changes • Histone-modifying SUV39H1 relies on its chromodomain for locus repositioning, Wijchers et al. combine 4C technology with lacO/lacR binding platforms to show that a given genomic locus can adopt multiple nuclear positions depending on the recruited protein. Focal protein recruitment can move an entire subTAD, but repositioning appeared largely unrelated to changes in its chromatin composition and activity.
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- 2016
7. Run! : developing a high tech running path in the park
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Megens, C., Neutelings, I. M. P., Hout, B. F. K., Mark Janssen, Steven Vos, and Industrial Design
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- 2016
8. Increased plasma corticosterone levels after periaqueductal gray stimulation-induced escape reaction or panic attacks in rats
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Mujzgan Aziz-Mohammadi, Ali Jahanshahi, Yasin Temel, Rinske Vlamings, Lee Wei Lim, Veerle Visser-Vandewalle, Marlies van Duinen, Mark Janssen, Harry W.M. Steinbusch, Sonny K.H. Tan, Koen Schruers, Arjan Blokland, RS: FPN NPPP II, Neuropsychology & Psychopharmacology, and Psychiatrie & Neuropsychologie
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Male ,medicine.medical_specialty ,Radioimmunoassay ,Fluorescent Antibody Technique ,Escape response ,Stimulation ,Citalopram ,Periaqueductal gray ,Buspirone ,Behavioral Neuroscience ,chemistry.chemical_compound ,Escape Reaction ,Corticosterone ,Internal medicine ,medicine ,Animals ,Periaqueductal Gray ,Rats, Wistar ,Neurons ,Analysis of Variance ,Chemistry ,Panic ,Electric Stimulation ,Rats ,Endocrinology ,Anti-Anxiety Agents ,Hypothalamus ,medicine.symptom ,Proto-Oncogene Proteins c-fos ,Selective Serotonin Reuptake Inhibitors ,Glucocorticoid ,medicine.drug - Abstract
The hypothalamo-pituitary-adrenal (HPA) axis is involved in stress, depression and anxiety. Controversy exists on HPA axis activation during panic attacks (PAs). We examined whether the HPA axis is involved in the escape or panic-like response in an animal model of PAs induced by electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) in rats. Additionally, rats were also treated with chronic administration of buspirone (BUSP) and escitalopram (ESCIT), respectively; and they were stimulated in the open-field arena for panic-like reaction. Levels of stress hormone corticosterone were measured following 30 min after escape or panic condition. Our results demonstrated that the levels of plasma corticosterone were significantly increased after the induction of escape or panic-like response in comparison with the sham animals. The levels of corticosterone were significantly decreased in the dlPAG stimulated groups after rats were treated chronically with the ESCIT but not the BUSP as compared to the saline treated animals. Importantly, the increase of corticosterone level after escape or panic-like response was paralleled by an increase of neuronal activation of c-Fos in both the parvocellular and magnocellular paraventricular nucleus of the hypothalamus. Moreover, the c-Fos data also showed a decrease in the number of positive cells particularly for the ESCIT as well as the BUSP in comparison with the saline stimulated animals. In conclusion, the present study clearly demonstrated that PA or escape response activates the HPA axis and it remains difficult to anticipate the mechanism underlying HPA axis during PAs and its relationship with 5-HT drugs.
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- 2011
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9. Ozarks Isoprene Experiment (OZIE): Measurements and modeling of the 'isoprene volcano'
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Bryan P. Long, Brian Hopkins, Brian Lamb, Hal Westberg, Gabrielle Pétron, W. Baugh, Paul I. Palmer, Thomas Pierce, Peter Harley, Jim Greenberg, Christine Wiedinmyer, Mark Janssen, Alex Guenther, Mike Koerber, Kirk R. Baker, Chris Geron, Jay R. Turner, and Physical Chemistry
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Atmospheric Science ,Ozone ,Chemical transport model ,Meteorology ,Soil Science ,Aquatic Science ,Oceanography ,Atmospheric sciences ,Spatial distribution ,chemistry.chemical_compound ,Geochemistry and Petrology ,Earth and Planetary Sciences (miscellaneous) ,Mixing ratio ,Isoprene ,Earth-Surface Processes ,Water Science and Technology ,geography ,geography.geographical_feature_category ,Ecology ,Biogenic emissions ,Paleontology ,Forestry ,Spatial heterogeneity ,Geophysics ,chemistry ,Volcano ,Space and Planetary Science ,Environmental science - Abstract
[1] The Ozarks Isoprene Experiment (OZIE) was conducted in July 1998 in Missouri, Illinois, Indiana, and Oklahoma. OZIE was designed to investigate the presumed strong isoprene emission rates from the Missouri Ozarks, where there is a high density of oak trees that are efficient isoprene emitters. Ground, balloon, and aircraft measurements were taken over a three-week study period; 0-D and 3-D chemical models were subsequently used to better understand the observed isoprene emissions from the Ozarks and to investigate their potential regional-scale impacts. Leaf-level measurements for two oak tree species yielded normalized average isoprene emission capacities of 66 mgC g−1 h−1, in good agreement with values used in current biogenic emissions models. However, the emission capacities exhibited a temperature dependence that is not captured by commonly used biogenic emission models. Isoprene mixing ratios measured aloft from tethered balloon systems were used to estimate isoprene fluxes. These measurement-derived fluxes agreed with BEIS3 estimates within the relatively large uncertainties in the estimates. Ground-level isoprene mixing ratios exhibited substantial spatial heterogeneity, ranging from
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- 2005
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10. Solid pseudopapillary tumor of the pancreas diagnosed postpartum
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Daniel R. Marcus, Mark Janssen, Sergio Huerta, and Physical Chemistry
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Adult ,medicine.medical_specialty ,business.industry ,Puerperal Disorders ,Carcinoma, Papillary ,Surgery ,Solid pseudopapillary tumor ,Pancreatic Neoplasms ,Radiography ,medicine.anatomical_structure ,Treatment Outcome ,medicine ,Humans ,Female ,Radiology ,Pancreas ,Solid tumor ,business - Published
- 2005
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