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Landslides affect nearly every country in the world each year. To better understand this global hazard, the Landslide Hazard Assessment for Situational Awareness (LHASA) model was developed previously. LHASA version 1 combines satellite precipitation estimates with a global landslide susceptibility map to produce a gridded map of potentially hazardous areas from 60° North-South every 3 h. LHASA version 1 categorizes the world’s land surface into three ratings: high, moderate, and low hazard with a single decision tree that first determines if the last seven days of rainfall were intense, then evaluates landslide susceptibility. LHASA version 2 has been developed with a data-driven approach. The global susceptibility map was replaced with a collection of explanatory variables, and two new dynamically varying quantities were added: snow and soil moisture. Along with antecedent rainfall, these variables modulated the response to current daily rainfall. In addition, the Global Landslide Catalog (GLC) was supplemented with several inventories of rainfall-triggered landslide events. These factors were incorporated into the machine-learning framework XGBoost, which was trained to predict the presence or absence of landslides over the period 2015–2018, with the years 2019–2020 reserved for model evaluation. As a result of these improvements, the new global landslide nowcast was twice as likely to predict the occurrence of historical landslides as LHASA version 1, given the same global false positive rate. Furthermore, the shift to probabilistic outputs allows users to directly manage the trade-off between false negatives and false positives, which should make the nowcast useful for a greater variety of geographic settings and applications. In a retrospective analysis, the trained model ran over a global domain for 5 years, and results for LHASA version 1 and version 2 were compared. Due to the importance of rainfall and faults in LHASA version 2, nowcasts would be issued more frequently in some tropical countries, such as Colombia and Papua New Guinea; at the same time, the new version placed less emphasis on arid regions and areas far from the Pacific Rim. LHASA version 2 provides a nearly real-time view of global landslide hazard for a variety of stakeholders.

This study measures the availability of menthol cigarettes in Oakland, California where such products were banned from the majority of tobacco retailers, except for those who sold a significant amount of tobacco (e.g., 60% gross income). Out of a total of 385 retailers in Oakland, only forty-eight retailers were exempt from this ban at the time of data collection. In February 2019, seven months after the ban went into effect, we selected a stratified random sample of 15 census tracts, based on race/ethnicity. In pairs, data collectors walked on opposite sides of the street and collected all discarded cigarette packs (n = 641) from the streets and sidewalks on weekdays. Overall, we found almost half (46.0%; 95% CI = 32.6%–59.3%) of the packs collected were menthol, with Newport as the dominant brand. We found at least one pack of menthol cigarettes in 14 of the 15 sampled census tracts. In predominantly black/African American census tracts, the proportion of menthol cigarettes collected was significantly higher (70.1%; 95% CI = 62.6%–77.7%) when compared to mixed race/ethnicity (55.9%; 95% CI = 41.0–70.9%) and white tracts (35.1%; 95% CI = 13.2%–57.1%). Finally, there was a moderate and negative correlation between distance to exempt tobacco retailer and menthol availability (r = −0.66, p

ABSTRACT When it comes to court packing, questions of "should" and "can" are inextricably intertwined. The conventional wisdom has long been that federal court packing is something the President and [...]

Aminoglycosides are concentration-dependent antibiotics exerting a bactericidal effect when concentrations at the site of infection are equal to or greater than 5 times the minimum inhibitory concentrations (MIC). When administered intravenously, they exhibit poor lung penetration and high systemic renal and ototoxicity, imposing to restrict their administration to 5 days. Experimental studies conducted in anesthetized and mechanically ventilated sheep and pigs provide evidence that high doses of nebulized aminoglycosides induce a rapid and potent bacterial killing in the infected lung parenchyma. They also confirm that the alveolar-capillary membrane, either normal or injured by the infectious process, restricts the penetration of intravenous aminoglycosides in the infected lung parenchyma, precluding a bactericidal effect at the site of infection. However, injury of the alveolar-capillary membrane promotes the systemic diffusion of nebulized aminoglycosides. Based on experimental data obtained in animals with inoculation pneumonia, it challenges the classical belief that nebulization protects against systemic toxicity. Loss of lung aeration decreases the lung penetration of nebulized aminoglycosides. Nevertheless, lung tissue concentrations measured in non-aerated lung regions with severe and extended pneumonia are most often greater than 5 times the MICs, resulting in a bactericidal effect followed by a progressive pulmonary reaeration. It is likely that the penetration into the consolidated lung, results from the bronchial diffusion of nebulized aminoglycosides toward adjacent non-aerated infected alveolar spaces and their penetration into mechanical ventilation-induced intraparenchymal pseudocysts and distended bronchioles. In animals receiving nebulized aminoglycosides, epithelial lining fluid concentrations grossly overestimate lung interstitial fluid concentrations because of the bronchial contamination of the distal tip of the bronchoscope during the bronchoalveolar procedures. Lung microdialysis is the only technique able to accurately assess lung pharmacokinetics in animals with inoculation pneumonia treated by nebulized aminoglycosides. In 2024, the European Investigators Network for Nebulized Antibiotics in Ventilator-associated Pneumonia (ENAVAP) called for the creation of an international research network for Lung Microdialysis applied to Nebulized Antibiotics (LUMINA) to promote multicentered, experimental, randomized, and controlled studies addressing lung pharmacokinetics of intravenous vs. nebulized antibiotics, using different dosing and ventilator settings.

The paper deals with the problem of conflicts between fundamental rights by presenting and analysing one of the possible methods for the resolution of such conflicts. The method in question is the so-called interpretative-subsumptive method, developed by Spanish legal philosopher Juan Antonio García Amado. The interpretative-subsumptive method represents an alternative to the mainstream method used for the resolution of conflicts between fundamental rights – judicial balancing, and particularly the version developed by Robert Alexy. After the introduction, interpretative-subsumptive method is contextualised by presenting Garcia Amado’s ideas which are of relevance for the inquiry – his inclusive legal positivist views, the theory of legal interpretation he ascribes to and his understanding and typology of fundamental rights and their conflicts. After that, in the central section of the paper, the theoretical framework of the interpretative-subsumptive method is presented, along with its application to a Spanish Supreme Court case, followed by the criticism that has been raised and ending with conclusions.

The article explores overlooked aspects of judicial roles, emphasizing how judges manage caseloads and interactions within the court. It covers appellate judges' strategies for timely opinions, transitions like senior status, and the internal management of collegial norms amid court turnover. It aims to prompt further research on judicial administration dynamics.

Abstract Purpose During resuscitation in emergency situations, establishing intravascular access is crucial for promptly initiating delivery of fluids, blood, blood products, and medications. In cases of emergency, when intravenous (IV) access proves unsuccessful, intraosseous (IO) access serves as a viable alternative. However, there is a notable lack of information concerning the frequency and efficacy of IO access in acute care settings. This study aims to assess the efficacy of intraosseous (IO) access in acute care settings, especially focusing on children in a level 1 trauma center. Methods This retrospective study included patients with IO access presented in a level 1 trauma center emergency department (ED) between January 2015 and April 2020. Data regarding medication and fluid infusion was documented, and the clinical success rate was calculated. Results Of the 109,548 patients that were admitted to the ED, 25,686 IV lines were inserted. Documentation of 188 patients of which 73 (38.8%) children was complete and used for analysis. In these 188 patients, a total of 232 IO accesses were placed. Overall, 182 patients had a functional IO access (204 needles) (88%). In children (age

Abstract Background Research into the genetic diversity of honey bee (Apis mellifera L.) populations has become increasingly significant in recent decades, primarily due to population declines attributed to human activities and climate change. As a species of great importance, breeding programs that leverage understanding of genomic diversity could offer solutions to mitigate these challenges. The objective of this study was to examine the genomic diversity and population structure of Carniolan honey bees (Apis mellifera carnica) using the Illumina SNP chip on a large honey bee sample collected from Central and South-Eastern European countries. The study also aims to offer recommendations for future breeding programs. Results Our analysis involved Discriminant Analysis of Principal Components (DAPC), heterozygosity, admixture analysis, fixation indices (FST), Neighbour-Joining tree, gene flow and Isolation-by-distance analysis. DAPC indicated distinct separation between the Carniolan and Italian honey bee (Apis mellifera ligustica) populations, whereas the admixture analysis revealed varying levels of gene flow and genetic admixture within the Carniolan honey bee populations, demonstrating closer relationships between specific geographic regions (confirmed by Isolation-by-distance analysis). Furthermore, the research of heterozygosity, genomic inbreeding, pairwise FST values, and Neighbour-Joining tree provided insights into the patterns of genetic differentiation and similarity among the populations of Carniolan honey bee within its natural habitat. We have observed genetic homogeneity of the Carniolan honey bee population when considered in a broader genetic/geographical context. However, the Carniolan honey bee has sufficient genetic diversity in its geographical home range that needs to be carefully monitored and maintained. Conclusions This study provides important insights into the genetic composition, differentiation, and relationships among Carniolan honey bee populations in Central and South-Eastern European countries. The findings are crucial for conservation efforts, breeding programs, and sustainable beekeeping practices. They emphasise the importance of considering genetic factors and population structure in the breeding and management of honey bees. By understanding these genetic relationships, we can develop strategies to preserve genetic diversity, improve breeding outcomes, and ensure the resilience of honey bee populations in the face of environmental changes and challenges. This knowledge can also inform policy makers and stakeholders on best practices to maintain healthy bee populations, which are vital for ecosystem services and agricultural productivity.

El artículo presenta los alcances e implicaciones de los discursos que ofrecen respuesta a la pregunta de si todos, algunos o ningún aplicador del derecho deberían ser competentes para realizar ponderaciones como forma de crear una excepción a una norma o realizar un distinguish a un precedente. Asimismo, analiza cuáles son los riesgos que deben evaluarse para determinar: i) quiénes deben tener la competencia para resolver una laguna axiológica; y ii) si debe ser una competencia limitada o no (y qué tipo de límites regular). Para ello, presenta en qué tipo de casos se emplea la ponderación, qué quiere decir que un aplicador del derecho es competente para ponderar, qué riesgos produce dicha competencia y, finalmente, propone modelos de administración de riesgos en función a cómo se diseñe la norma que otorga competencia para ponderar.

Injustice on Appeal: The United States Courts of Appeals in Crisis BY WILLIAM M. RICHMAN & WILLIAM L. REYNOLDS NEW YORK, NY: OXFORD UNIVERSITY PRESS, 2012, PP. 256. $89.50. REVIEW [...]

Mountains are important suppliers of freshwater to downstream areas, affecting large populations in particular in High Mountain Asia (HMA). Yet, the propagation of water from HMA headwaters to downstream areas is not fully understood, as interactions in the mountain water cycle between the cryo-, hydro- and biosphere remain elusive. We review the definition of blue and green water fluxes as liquid water that contributes to runoff at the outlet of the selected domain (blue) and water lost to the atmosphere through vapor fluxes, that is evaporation from water, ground, and interception plus transpiration (green) and propose to add the term white water to account for the (often neglected) evaporation and sublimation from snow and ice. We provide an assessment of models that can simulate the cryo-hydro-biosphere continuum and the interactions between spheres in high mountain catchments, going beyond disciplinary separations. Land surface models are uniquely able to account for such complexity, since they solve the coupled fluxes of water, energy, and carbon between the land surface and atmosphere. Due to the mechanistic nature of such models, specific variables can be compared systematically to independent remote sensing observations – providing vital insights into model accuracy and enabling the understanding of the complex watersheds of HMA. We discuss recent developments in spaceborne earth observation products that have the potential to support catchment modeling in high mountain regions. We then present a pilot study application of the mechanistic land surface model Tethys & Chloris to a glacierized watershed in the Nepalese Himalayas and discuss the use of high-resolution earth observation data to constrain the meteorological forcing uncertainty and validate model results. We use these insights to highlight the remaining challenges and future opportunities that remote sensing data presents for land surface modeling in HMA.

Structural patterns, global positioning system (GPS) velocities, and Quaternary fault slip rates in northeastern Tibet indicate a transfer of left-lateral slip from the Kunlun fault northeast to the Haiyuan fault and minor crustal shortening and rotation within a 200-km-wide stepover zone. Related deformation also continues at least a few hundred kilometers north of the Haiyuan fault into a region of diffuse extensional(?) shear or rotation underlain by average thickness crust. Fast, localized slip along the central Kunlun fault transforms into distributed deformation across a 500-km-wide zone where the lower crust is weak. The distribution of fault-parallel GPS velocities across this region suggests a decrease in fault slip toward eastern fault tips and progressive dissipation of slip to the north rather than east of the Tibetan Plateau as previously suggested. doi: 10.1130/G30711.1

Crustal deformation along the present-day northern margin of the Tibetan Plateau has occurred since mid to late Eocene time, soon after India collided with Eurasia. Assuming that on these distance and time scales the lithosphere can be approximated using a thin viscous sheet, we show that far-field lithospheric deformation caused by an indenting boundary is expected to start shortly after collision begins. When a strong region analogous to cratonic lithosphere like that of the Tarim Basin is included in the calculations, shear and vertical strain rates concentrate along the southern edge of the strong region, resulting in enhanced deformation there. In calculations scaled to the dimensions of India and the Tibetan Plateau, shear and vertical strain rates on the northern edge of the plateau increase soon after collision begins. Crustal thickening accelerates later in the calculations. We propose that the apparent increased exhumation (and perhaps surface uplift) around 10 Ma may signal the arrival of the thickening front. Citation: Dayem, K. E., P. Molnar, M. K. Clark, and G. A. Houseman (2009), Far-field lithospheric deformation in Tibet during continental collision, Tectonics, 28, TC6005, doi: 10.1029/2008TC002344.

The advancement of pharmaceutical science has resulted in the development of numerous tailor-made compounds, i.e., pharmaceuticals, tuned for specific drug targets. These compounds are often characterized by their low biodegradability and are commonly excreted to a certain extent unchanged from the human body. Due to their low biodegradability, these compounds represent a significant challenge to wastewater treatment plants. Often, these compounds end up in effluents in the environment. With the advancement of membrane technologies and advanced oxidation processes, photocatalysis in particular, a synergistic approach between the two was recognized and embraced. These hybrid advanced water treatment processes are the focus of this review, specifically the removal of pharmaceuticals from water using a combination of a photocatalyst and pressure membrane process, such as reverse osmosis or nanofiltration employing photocatalytic nanocomposite membranes.

Abstract Background Child abuse and neglect (CAN) is prevalent, associated with long-term adversities, and often undetected. Primary care settings offer a unique opportunity to identify CAN and facilitate referrals, when warranted. Electronic health records (EHR) contain extensive information to support healthcare decisions, yet time constraints preclude most providers from thorough EHR reviews that could indicate CAN. Strategies that summarize EHR data to identify CAN and convey this to providers has potential to mitigate CAN-related sequelae. This study used expert review/consensus and Natural Language Processing (NLP) to develop and test a lexicon to characterize children who have experienced or are at risk for CAN and compared machine learning methods to the lexicon + NLP approach to determine the algorithm’s performance for identifying CAN. Methods Study investigators identified 90 CAN terms and invited an interdisciplinary group of child abuse experts for review and validation. We then used NLP to develop pipelines to finalize the CAN lexicon. Data for pipeline development and refinement were drawn from a randomly selected sample of EHR from patients seen at pediatric primary care clinics within a U.S. academic health center. To explore a machine learning approach for CAN identification, we used Support Vector Machine algorithms. Results The investigator-generated list of 90 CAN terms were reviewed and validated by 25 invited experts, resulting in a final pool of 133 terms. NLP utilized a randomly selected sample of 14,393 clinical notes from 153 patients to test the lexicon, and .03% of notes were identified as CAN positive. CAN identification varied by clinical note type, with few differences found by provider type (physicians versus nurses, social workers, etc.). An evaluation of the final NLP pipelines indicated 93.8% positive CAN rate for the training set and 71.4% for the test set, with decreased precision attributed primarily to false positives. For the machine learning approach, SVM pipeline performance was 92% for CAN + and 100% for non-CAN, indicating higher sensitivity than specificity. Conclusions The NLP algorithm’s development and refinement suggest that innovative tools can identify youth at risk for CAN. The next key step is to refine the NLP algorithm to eventually funnel this information to care providers to guide clinical decision making.

Shallow bedrock strength controls both landslide hazard and the rate and form of erosion, yet regional patterns in near‐surface mechanical properties are rarely known quantitatively due to the challenge in collecting in situ measurements. Here we present seismic and geomechanical characterizations of the shallow subsurface across the central Himalayan Range in Nepal. By pairing widely distributed 1D shear wave velocity surveys and engineering outcrop descriptions per the Geological Strength Index classification system, we evaluate landscape‐scale patterns in near‐surface mechanical characteristics and their relation to environmental factors known to affect rock strength. We find that shallow bedrock strength is more dependent on the degree of chemical and physical weathering, rather than the mineral and textural differences between the metamorphic lithologies found in the central Himalaya. Furthermore, weathering varies systematically with topography. Bedrock ridge top sites are highly weathered and have S‐wave seismic velocities and shear strength characteristics that are more typical of soils, whereas sites near valley bottoms tend to be less weathered and characterized by high S‐wave velocities and shear strength estimates typical of rock. Weathering on hillslopes is significantly more variable, resulting in S‐wave velocities that range between the ridge and channel endmembers. We speculate that variability in the hillslope environment may be partly explained by the episodic nature of mass wasting, which clears away weathered material where landslide scars are recent. These results underscore the mechanical heterogeneity in the shallow subsurface and highlight the need to account for variable bedrock weathering when estimating strength parameters for regional landslide hazard analysis. Plain Language Summary: Rock strength controls the occurrence of landslides and the relationship between topography and erosion, but it is rarely known in natural environments because the most common measurement techniques are designed for individual site characterization and they are time‐consuming to apply over broad spatial scales. In this paper, we apply a unique sampling strategy consisting of two field‐based measurement techniques that are relatively portable and quick to apply repeatedly, and provide rock strength information over the scale of an outcrop (tens of meters). We apply our approach to an area of central Nepal where rock strength estimates are particularly important to know due to the high landslide hazard in this region. Our results show that rock strength is strongly controlled by the degree of weathering (i.e., the breakdown of rock by chemical and physical processes), which varies widely in Nepal depending on the local climate and topographic characteristics. In particular, we find that weathering is systematically greater (and thus rock strength is lower) on ridges compared to valley bottoms. On hillslopes between ridges and valleys, both weathering and rock strength are highly variable and difficult to predict, highlighting the need to further investigate regional variability in rock strength for future landslide hazard assessment. Key Points: We employ seismic surveys and geomechanical rockmass characterizations to investigate regional patterns in rock strengthNo single variable explains the observed patterns in near‐surface mechanical properties within this tectonically active terrainWeathering characteristics associated with ridge‐to‐channel topography contributes order‐of‐magnitude variations in near‐surface strength [ABSTRACT FROM AUTHOR]

The harvesting time of olive (Olea europaea L.) fruit, which significantly affects the characteristics of virgin olive oil, is mainly determined empirically based on the fruit’s skin color. Developing objective methods such as electrical impedance spectroscopy (EIS) for assessing ripeness is essential. This study aimed to explore the potential of EIS as a rapid and objective technique for detecting the harvesting time of olives. Olive fruits from two varieties, ‘Picholine’ and ‘Buža momjanska’, were harvested in two periods and sorted into four color groups. EIS was applied to each color group to establish a relationship between fruit color and electrochemical properties. The distance of the coordinate at the top of the circular arc of the Cole–Cole plot from the origin (LTO) indicated tissue degradation. The LTO values varied depending on the olive variety, fruit color, and harvest date. The LTO values decreased from green to black fruits in both varieties, indicating textural changes in the olive fruit tissue. This study contributes to the knowledge and understanding of the electrical properties of olive fruit tissue during ripening. EIS shows potential as an innovative tool for determining the harvesting time of olives and for ‘in-field’ olive ripeness assessment.

The food industry is developing intensively, and products that, with their characteristics, enrich the food taste and aroma are widely used in the culinary arts. White wine vinegar is often used as a food condiment and as dressing in salads. This research aims to explore the impact of the maceration of selected aromatic plants on the organoleptic properties, bioactive compounds, and sensory profile of white wine vinegar. The plants selected for white wine (cv ‘Malvazija istarska’) vinegar aromatization were rosemary (Rosmarinus officinalis L.) and thyme (Thymus serpyllum L.) dried leaves and black elder (Sambucus nigra L. ssp. nigra) flowers (elderflowers). Vinegar flavored with rosemary had more pronounced pinewood and herbal aromas, while spicy aromas dominated the vinegar with thyme. The elderflower-flavored vinegar, on the other hand, was characterized by a floral and fruity aroma. Among the analyzed vinegars, white wine vinegar flavored with elderflower had the highest polyphenolic content.

Contractional deformation is common along transform plate margins where plate motion is oblique to the plate boundary. While faults that accommodate this deformation are often inferred to be subsidiary to the main plate boundary fault, we typically lack direct geometric or kinematic information. Here we investigate the timing of faulting relative to changes in the orientation of the North American-Pacific plate boundary. Coeval with development of an oblique plate boundary segment (i.e., the "Big Bend" of the San Andreas fault), active shortening is inferred to have initiated at ~5 Ma in the Western Transverse Ranges (WTR). However, new low-temperature thermochronometric data yield Miocene to Pleistocene apatite (U-Th-Sm)/He cooling ages and partially reset zircon (U-Th)/He ages. Inverse thermal modeling indicate that reverse faulting initiated as early as 10 Ma, several million years prior to our current understanding of the timing of the Big Bend. Reverse faults in the WTR also propagate from west to east, toward the San Andreas Fault, rather than outwards from it. New and existing thermochronometry data delineate the WTR as the locus of rapid post-Miocene exhumation, and demonstrate that similar exhumation is not present in the broader region surrounding the Big Bend. We posit that reverse faulting is localized in the WTR because of a weak underlying lithosphere and predates the more recent geometric anomaly of the restraining bend in the transform margin. [ABSTRACT FROM AUTHOR]

Aims: We examined the cardiovascular effects of celiac disease (CeD) in a humanized mouse model, with a focus on vascular inflammation, endothelial dysfunction, and oxidative stress. Methods and results: NOD.DQ8 mice genetically predisposed to CeD were subjected to a diet regime and oral gavage to induce the disease (gluten group vs. control). We tested vascular function, confirmed disease indicators, and evaluated inflammation and oxidative stress in various tissues. Plasma proteome profiling was also performed.CeD markers were confirmed in the gluten group, indicating increased blood pressure and impaired vascular relaxation. Pro-inflammatory genes were upregulated in this group, with increased CD11b+ myeloid cell infiltration and oxidative stress parameters observed in aortic and heart tissue. However, heart function remained unaffected. Plasma proteomics suggested the cytokine interleukin-17A (IL-17A) as a link between gut and vascular inflammation. Cardiovascular complications were reversed by adopting a gluten-free diet. Conclusion: Our study sheds light in the heightened cardiovascular risk associated with active CeD, revealing a gut-to-cardiovascular inflammatory axis potentially mediated by immune cell infiltration and IL-17A. These findings augment our understanding of the link between CeD and cardiovascular disease providing clinically relevant insight into the underlying mechanism. Furthermore, our discovery that cardiovascular complications can be reversed by a gluten-free diet underscores a critical role for dietary interventions in mitigating cardiovascular risks associated with CeD.

Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization concluded that chronic exposure to road traffic noise is a risk factor for ischemic heart disease. In contrast, they concluded that the quality of evidence for a link to other diseases was very low to moderate. Since then, several studies on the impact of noise on various diseases have been published. Also, studies investigating the mechanistic pathways underlying noise-induced health effects are emerging. We review the current evidence regarding effects of noise on health and the related disease-mechanisms. Several high-quality cohort studies consistently found road traffic noise to be associated with a higher risk of ischemic heart disease, heart failure, diabetes, and all-cause mortality. Furthermore, recent studies have indicated that road traffic and railway noise may increase the risk of diseases not commonly investigated in an environmental noise context, including breast cancer, dementia, and tinnitus. The harmful effects of noise are related to activation of a physiological stress response and nighttime sleep disturbance. Oxidative stress and inflammation downstream of stress hormone signaling and dysregulated circadian rhythms are identified as major disease-relevant pathomechanistic drivers. We discuss the role of reactive oxygen species and present results from antioxidant interventions. Lastly, we provide an overview of oxidative stress markers and adverse redox processes reported for noise-exposed animals and humans. This position paper summarizes all available epidemiological, clinical, and preclinical evidence of transportation noise as an important environmental risk factor for public health and discusses its implications on the population level.

Abstract Nanodisc technology has dramatically advanced the analysis of molecular interactions for membrane proteins. A nanodisc is designed as a vehicle for membrane proteins that provide a native-like phospholipid environment and better thermostability in a detergent-free buffer. This enables the determination of the thermodynamic and kinetic parameters of small molecule binding by surface plasmon resonance. In this study, we generated a nanodisc specific anti-MSP (membrane scaffold protein) monoclonal antibody biND5 for molecular interaction analysis of nanodiscs. The antibody, biND5 bound to various types of nanodiscs with sub-nanomolar to nanomolar affinity. Epitope mapping analysis revealed specific recognition of 8 amino acid residues in the exposed helix-4 structure of MSP. Further, we performed kinetics binding analysis between adenosine A2a receptor reconstituted nanodiscs and small molecule antagonist ZM241385 using biND5 immobilized sensor chips. These results show that biND5 facilitates the molecular interaction kinetics analysis of membrane proteins substituted in nanodiscs.

Abstract Wildfire alters the hydrologic cycle, with important implications for water supply and hazards including flooding and debris flows. In this study we use a combination of electrical resistivity and stable water isotope analyses to investigate the hydrologic response during storms in three catchments: one unburned and two burned during the 2020 Bobcat Fire in the San Gabriel Mountains, California, USA. Electrical resistivity imaging shows that in the burned catchments, rainfall infiltrated into the weathered bedrock and persisted. Stormflow isotope data indicate that the amount of mixing of surface and subsurface water during storms was similar in all catchments, despite higher streamflow post-fire. Therefore, both surface runoff and infiltration likely increased in tandem. These results suggest that the hydrologic response to storms in post-fire environments is dynamic and involves more surface-subsurface exchange than previously conceptualized, which has important implications for vegetation regrowth and post-fire landslide hazards for years following wildfire.

Rock mass strength is recognized as an important control on landscape morphology and evolution. However, the controls on rock strength in mountainous topography remain poorly characterized, in part because strength remains challenging to quantify at spatial scales relevant to geomorphology. Here we quantify the mechanical properties of rock masses using subsurface S‐wave velocities, Schmidt hammer hardness values, and Geological Strength Index (GSI) observations. We produce shallow depth profiles of rock mass shear strength using intact rock hardness as measured from a Schmidt hammer, and assessment of the structure and surface conditions of fractures using GSI. We apply these techniques to the Western Transverse Ranges, southern California, USA, where gradients in stratigraphic age and erosion rate allow us to evaluate our methodology. We resolve strength differences of 200 kPa to ∼5 MPa that appear to be related to diagenetic changes associated with the maximum burial depth of young clastic sedimentary rocks. For rocks of the same lithologic type, stratigraphic age, and inferred burial histories, we resolve smaller differences in strength (300 kPa–1.5 MPa) that appear to be positively correlated with mean erosion rates. We suggest that the increase in strength with increasing erosion rate reflects decreased residence time in the weathering zone for ranges experiencing faster fault slip rates. These findings demonstrate up to an order of magnitude variability in strength with respect to burial, erosion, and time for lithologically similar rocks. As such, lithology alone is unlikely to adequately capture the role of rock strength in landscape evolution. Key Points: We present a novel approach to quantify near‐surface rock mass strength on depth profiles from surface and subsurface measurementsThe rock mass strength of sandstone units increases with increasing maximum burial depth prior to exhumationRock strength and erosion rate are positively correlated, which we suggest is driven by critical zone residence time and weathering extent [ABSTRACT FROM AUTHOR]

Presented data includes two datasets named RealSAR-RAW and RealSAR-IMG. The first one contains unprocessed (raw) radar data obtained using Ground Based Synthetic Aperture Radar (GBSAR), while the second one contains images reconstructed using Omega-K algorithm applied to raw data from the first set. The GBSAR system moves the radar sensor along the track to virtually extend (synthesize) the antenna aperture and provides imaging data of the area in front of the system. The used sensor was a Frequency Modulated Continuous Wave (FMCW) radar with a central frequency of 24 GHz and a 700 MHz wide bandwidth which in our case covered the observed scene in 30 steps with 1 cm step size. The measured (recorded) scenes were made on combinations of three test objects (bottles) made of different material (aluminum, glass, and plastic) in different positions. The aim was to develop a small dataset of GBSAR data useful for classification applications focused on distinguishing different materials from sparse radar data.

Abstract Perovskite BiFe0.9Co0.1O3 with electric‐field‐induced magnetization reversal is a promising material for low‐power non‐volatile memory devices because spontaneous magnetization perpendicular to the electric polarization can be reversed by out‐of‐plane polarization reversal. In this study, magnetic and ferroelectric domain changes in BiFe0.9Co0.1O3 after applying an in‐plane electric field with counter electrodes fabricated by lithography is investigated. Electric poling can be performed up to 100 times via 71° polarization switching without disrupting the ferroelectric domains. It is determined that the correlation between the ferroelectric and magnetic domains is preserved, while in‐plane 71° polarization switching without reconstructing the ferroelectric domains does not change its out‐of‐plane magnetization. Lastly, possible differences in the antiferromagnetic spin vector and magnetization direction for in‐plane and out‐of‐plane 71° switching is discussed.

IMPORTANCE:. The interhospital transfer (IHT) of patients with sepsis to higher-capability hospitals may improve outcomes. Little is known about patient and hospital factors associated with sepsis IHT. OBJECTIVES:. We evaluated patterns of hospitalization and IHT and determined patient and hospital factors associated with the IHT of adult patients with sepsis. DESIGN:. Retrospective cohort study. SETTING AND PARTICIPANTS:. A total of 349,938 adult patients with sepsis at 329 nonfederal hospitals in California, 2018–2019. MAIN OUTCOMES AND MEASURES:. We evaluated patterns of admission and outward IHT between low sepsis-, intermediate sepsis-, and high sepsis-capability hospitals. We estimated odds of IHT using generalized estimating equations logistic regression with bootstrap stepwise variable selection. RESULTS:. Among the cohort, 223,202 (66.4%) were initially hospitalized at high-capability hospitals and 10,870 (3.1%) underwent IHT. Nearly all transfers (98.2%) from low-capability hospitals were received at higher-capability hospitals. Younger age (< 65 yr) (adjusted odds ratio [aOR] 1.54; 95% CI, 1.40–1.69) and increasing organ dysfunction (aOR 1.22; 95% CI, 1.19–1.25) were associated with higher IHT odds, as were admission to low-capability (aOR 2.79; 95% CI, 2.33–3.35) or public hospitals (aOR 1.35; 95% CI, 1.09–1.66). Female sex (aOR 0.88; 95% CI, 0.84–0.91), Medicaid insurance (aOR 0.59; 95% CI, 0.53–0.66), home to admitting hospital distance less than or equal to 10 miles (aOR 0.92; 95% CI, 0.87–0.97) and do-not-resuscitate orders (aOR 0.48; 95% CI, 0.45–0.52) were associated with lower IHT odds, as was admission to a teaching hospital (aOR 0.83; 95% CI, 0.72–0.96). CONCLUSIONS AND RELEVANCE:. Most patients with sepsis are initially hospitalized at high-capability hospitals. The IHT rate for sepsis is low and more likely to originate from low-capability and public hospitals than from high-capability and for-profit hospitals. Transferred patients with sepsis are more likely to be younger, male, sicker, with private medical insurance, and less likely to have care limitation orders. Future studies should evaluate the comparative benefits of IHT from low-capability hospitals.