1. Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system
- Author
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Johanna Stefani, Marie-Cécile Faure, Baptiste Siffert, Sonia Louiba, Jean-Marc Bertho, Elie Tourlonias, François Paquet, Isabelle Dublineau, Laboratoire de radiotoxicologie et radiobiologie expérimentale (LRTOX), and Institut de Radioprotection et de Sûreté Nucléaire (IRSN)
- Subjects
Male ,Time Factors ,[SDV]Life Sciences [q-bio] ,Physiology ,Cesium ,drinking ,radiation exposure ,Mouse models ,030218 nuclear medicine & medical imaging ,Blood cell ,Eating ,Mice ,0302 clinical medicine ,Bagg albino mouse ,Models ,cytokine ,Ingestion ,animal ,Cell proliferation ,time ,Inbred BALB C ,General Environmental Science ,Mice, Inbred BALB C ,Radiation ,Reproduction ,article ,Age Factors ,Haematopoiesis ,fetus ,medicine.anatomical_structure ,Blood ,female ,Phenotype ,Cesium Radioisotopes ,030220 oncology & carcinogenesis ,Models, Animal ,Cytokines ,medicine.drug ,Blood cells ,Bone marrow cells ,Offspring ,Hematopoietic System ,Biophysics ,Spleen ,Concentration of ,Biology ,Biodistributions ,Peripheral blood mononuclear cell ,03 medical and health sciences ,Phenotypic analysis ,Potable water ,medicine ,Drinking water ,Hematopoietic systems ,Animals ,Animalia ,Bone marrow ,Bone ,mouse ,animal model ,Blood Cell Count ,Mononuclear cells ,age ,Erythropoietin ,Immunology ,cytology ,Cell culture - Abstract
The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of 137Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq l -1. Ingestion started in parent animals before mating, and 137Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. 137Cs content was measured in various organs, indicating that 137Cs was distributed throughout the organism including lymphohematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although 137Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function. © Springer-Verlag 2010.
- Published
- 2010
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