1. Bacterial colonization of the stomach and duodenum in a Swedish population with and without proton pump inhibitor treatment
- Author
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Jorge Alberto Arroyo Vázquez, Claes Henning, Per‐Ola Park, and Maria Bergström
- Subjects
bacteria ,gastric bacterial flora ,gastroscopy ,perforated ulcers ,proton pump inhibitor ,transgastric interventions ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background and Aim Microbial contamination of the abdominal cavity is a serious concern during transgastric endoscopic interventions and perforations, particularly in patients who have inhibited gastric acid secretion due to treatment with proton pump inhibitors (PPIs). The aim of this study was to investigate the gastric and duodenal bacterial flora in patients with and without PPI treatment. Methods Patients referred for gastroscopy, without recent antibiotic treatment, were eligible for inclusion. Use of PPIs was recorded. Samples for bacterial culturing were obtained from the antrum of the stomach and from the duodenal bulb through a gastroscope. Positive cultures were examined for bacterial types and subtypes. Biopsies were taken in the antrum for urease test to detect Helicobacter pylori. Results Bacterial cultures from the stomach were obtained from 103 patients, and duodenal samples were also cultured from 49 of them, for a total of 53 patients with PPI use and 50 patients without. Positive gastric cultures were found in 42 of 53 patients with PPI use and in 13 of 50 without (P
- Published
- 2020
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