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1,072 results on '"Margolis, David J."'

15. In utero or early-in-life exposure to antibiotics and the risk of childhood atopic dermatitis, a population-based cohort study.

Author

Fuxench, Zelma Chiesa, Mitra, Nandita, Pozo, Domenica Del, Hoffstad, Ole, Shin, Daniel B, Langan, Sinéad M, Petersen, Irene, Bhate, Ketaki, and Margolis, David J

Subjects
ATOPIC dermatitis, MEDICAL record databases, PROPORTIONAL hazards models, ELECTRONIC health records, COHORT analysis, ECZEMA
Abstract

Background Atopic dermatitis (AD) is a common inflammatory disease of the skin that begins early in life and can be lifelong. The purpose of our study was to evaluate whether fetal exposure and/or early-life exposure of a child to antibiotics increases the risk of early-onset AD. Objectives We hypothesize that antibiotic exposure in utero or early in life (e.g. first 90 days) increases the likelihood that children develop AD. Methods Utilizing a large, prospectively collected electronic medical records database, we studied the association of antibiotic exposure received in utero or very early in life and the relative risk of onset of AD in a population-based cohort study. Associations were estimated using proportional hazards models as hazard ratios (HRs) with 95% confidence intervals (CIs). Results The risk of AD in childhood was increased after in utero or early-life antibiotic exposure. For any in utero antibiotic exposure the HR (CI) was 1.38 (1.36–1.39). However, penicillin demonstrated the strongest association with AD for both in utero exposure [1.43 (1.41–1.44)] and for childhood exposure [1.81 (1.79–1.82)]. HRs were higher in children born to mothers without AD than in those with AD pointing to effect modification by maternal AD status. Conclusions Children born to mothers exposed to antibiotics while in utero had, depending on the mother's history of AD, approximately a 20–40% increased risk of developing AD. Depending on the antibiotic, children who received antibiotics early in life had a 40–80% increased risk of developing AD. Our study supports and refines the association between incident AD and antibiotic administration. It also adds population-based support to therapeutic attempts to treat AD by modifying the skin microbiome. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Multicenter Retrospective Study of 377 Adult Patients from the United States

Author

Micheletti, Robert G., Chiesa-Fuxench, Zelma, Noe, Megan H., Stephen, Sasha, Aleshin, Maria, Agarwal, Ashwin, Boggs, Jennifer, Cardones, Adela R., Chen, Jennifer K., Cotliar, Jonathan, Davis, Mark D.P., Dominguez, Arturo, Fox, Lindy P., Gordon, Shayna, Hamrick, Ronald, Ho, Baran, Hughey, Lauren C., Jones, Larry M., Kaffenberger, Benjamin H., Kindley, Kimball, Kroshinsky, Daniela, Kwong, Bernice Y., Miller, Daniel D., Mostaghimi, Arash, Musiek, Amy, Ortega-Loayza, Alex G., Patel, Raj, Posligua, Alba, Rani, Monica, Saluja, Sandeep, Sharon, Victoria R., Shinkai, Kanade, John, Jessica St., Strickland, Nicole, Summers, Erika M., Sun, Natalie, Wanat, Karolyn A., Wetter, David A., Worswick, Scott, Yang, Caroline, Margolis, David J., Gelfand, Joel M., and Rosenbach, Misha

Published
2018
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49. Melanoma risk in skin of colour patients with a history of a keratinocyte carcinoma.

Author

Mohr, Cassandra, Li, Yao, Navsaria, Lucy J, Hinkston, Candice L, Margolis, David J, and Wehner, Mackenzie R

Subjects
SKIN cancer, KERATINOCYTES, MELANOMA, CARCINOMA, MOHS surgery, HEALTH maintenance organizations
Abstract

This article discusses a study published in the British Journal of Dermatology that examines the risk of melanoma in patients with a history of keratinocyte carcinoma (KC), with a specific focus on skin of color patients. The study analyzed Medicare claims data from 2009 to 2018 and found that skin of color patients with KC had a higher risk of melanoma compared to patients with seborrhoeic keratosis (SK). The research emphasizes the importance of including skin of color patients in skin cancer studies and calls for further research in this population. Another aspect of the study examined the association between actinic keratosis (AK) and melanoma in Medicare patients aged 65 and older. The study found that a history of AK was associated with an 85% increased risk of melanoma in skin of color patients. However, the absolute risks of melanoma in this group were still low, at less than 1% at 5 years. The study acknowledges limitations, such as the use of claims data and the exclusion of certain patient categories. Overall, the study highlights the increased risk of melanoma in skin of color patients with a history of AK. [Extracted from the article]

Published
2024
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