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Ca ii K grains, i.e., intermittent, short-lived (about 1 minute), periodic (2–4 minutes), pointlike chromospheric brightenings, are considered to be the manifestations of acoustic waves propagating upward from the solar surface and developing into shocks in the chromosphere. After the simulations of Carlsson and Stein, we know that hot shocked gas moving upward interacting with the downflowing chromospheric gas (falling down after having been displaced upward by a previous shock) nicely reproduces the spectral features of the Ca ii K profiles observed in such grains, i.e., a narrowband emission-like feature at the blue side of the line core. However, these simulations are one-dimensional and cannot explain the location or the pointlike shape of the grains. Here, we report on the magnetic nature of these events. Furthermore, we report on similar events occurring at the largest flux concentrations, though they are longer-lived (up to 8 minutes) and exhibit the typical signature of steep velocity gradients traveling across the atmosphere. The spectral signatures of the studied events resemble their counterparts in sunspots, the umbral flashes. We then propose that magnetohydrodynamical waves are not only channeled through the magnetic field in sunspots, but they pervade the whole atmosphere. The propagation along magnetic fields can explain the pointlike appearance of the calcium grains observed in the quiet chromosphere.

Our clinical series comprises 124 patients with movement disorders (MDs) and/or ataxia with cerebellar atrophy (CA), many of them showing signs of neurodegeneration with brain iron accumulation (NBIA). Ten NBIA genes are accepted, although isolated cases compatible with abnormal brain iron deposits are known. The patients were evaluated using standardised clinical assessments of ataxia and MDs. First, NBIA genes were analysed by Sanger sequencing and 59 patients achieved a diagnosis, including the detection of the founder mutation PANK2 p.T528M in Romani people. Then, we used a custom panel MovDisord and/or exome sequencing; 29 cases were solved with a great genetic heterogeneity (34 different mutations in 23 genes). Three patients presented brain iron deposits with Fe-sensitive MRI sequences and mutations in FBXO7, GLB1, and KIF1A, suggesting an NBIA-like phenotype. Eleven patients showed very early-onset ataxia and CA with cortical hyperintensities caused by mutations in ITPR1, KIF1A, SPTBN2, PLA2G6, PMPCA, and PRDX3. The novel variants were investigated by structural modelling, luciferase analysis, transcript/minigenes studies, or immunofluorescence assays. Our findings expand the phenotypes and the genetics of MDs and ataxias with early-onset CA and cortical hyperintensities and highlight that the abnormal brain iron accumulation or early cerebellar gliosis may resembling an NBIA phenotype.

Tuberculosis causes more than 1.2 million deaths each year. Worldwide, it is the first cause of death by a single infectious agent. The emergence of drug-resistant strains has limited pharmacological treatment of the disease and today, new drugs are urgently needed. Semi-synthetic mulinanes have previously shown important activity against multidrug-resistant (MDR) Mycobacterium tuberculosis. In this investigation, a new set of semi-synthetic mulinanes were synthetized, characterized, and evaluated for their in vitro activity against three drug-resistant clinical isolates of M. tuberculosis: MDR, pre-extensively Drug-Resistant (pre-XDR), and extensively Drug-Resistant (XDR), and against the drug-susceptible laboratory reference strain H37Rv. Derivative 1a showed the best anti-TB activity (minimum inhibitory concentration [MIC] = 5.4 µM) against the susceptible strain and was twice as potent (MIC = 2.7 µM) on the MDR, pre-XDR, and XDR strains and also possessed a bactericidal effect. Derivative 1a was also tested for its anti-TB activity in mice infected with the MDR strain. In this case, 1a produced a significant reduction of pulmonary bacilli loads, six times lower than the control, when tested at 0.2536 mg/Kg. In addition, 1a demonstrated an adjuvant effect by shortening second-line chemotherapy. Finally, the selectivity index of >15.64 shown by 1a when tested on Vero cells makes this derivative an important candidate for future studies in the development of novel antitubercular agents.

Peace must be achieved among all; from within families in every home and school environments, through teachers and students. Relevant is the function that corresponds to the teacher in the daily work to fight for peace. To get there, you need to understand before some origins of violence from an early age of basic education. Mainly, with adolescents who go through a stage of life where they can touch the boundaries of violence and lost in it. To avoid this, parents and teachers should mark limits. Discipline, communication and prevention programs are some of the actions that are to be taken to achieve this. In schools, teachers’ challenges are enormous. To consolidate a culture of peace must live values as tolerance, freedom, responsibility, fairness, cooperation and respect. And so, achieve peace through equitable distribution of power.

To date, few cases of 3p proximal interstitial deletions have been reported and the phenotype and genotype correlation is not well understood. Here, we report a new case of a 3p proximal interstitial deletion. The patient is an 11-year-old female with speech and social interaction difficulties, learning disability, and slight facial dysmorphism, but no other major malformations. An 8 Mb de novo interstitial deletion at 3p14.2-p14.1, from position 60.461.316 to 68.515.453, was revealed by means of array comparative genomic hybridization and confirmed using quantitative reverse-transcription polymerase chain reaction assays. This region includes six genes: FEZF2, CADPS, SYNPR, ATXN7, PRICKLE, and MAGI1, that are known to have a role in neurodevelopment. These genes are located on the proximal side of the deletion. We compare our case with previously well-defined patients reported in the literature and databases.