1. Pulmonary complications of predominantly antibody immunodeficiencies in a tertiary lung center
- Author
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Karim Rahimi Aghdam, Maryam Hassanzad, M R Boloursaz, Mehrdad Bakhshayeshkaram, Sabereh Tashayoie-Nejad, Ali Akbar Velayati, Hosseinali Ghaffaripour, Guitti Pourdowlat, Seyed Karen Hashemitari, Nooshin Baghaie, Davood Mansouri, Jalal Heshmatnia, Seyed Alireza Mahdaviani, Alireza Eslaminejad, Atefeh Fakharian, Payam Tabarsi, Mahshid Movahedi, and Sepideh Darougar
- Subjects
Pediatrics ,medicine.medical_specialty ,complications ,morbidity ,Disease ,03 medical and health sciences ,0302 clinical medicine ,antibody ,medicine ,primary humoral immunodeficiencies ,030212 general & internal medicine ,Respiratory system ,Sinusitis ,Original Paper ,Lung ,Bronchiectasis ,biology ,business.industry ,General Medicine ,medicine.disease ,respiratory ,medicine.anatomical_structure ,Otitis ,030228 respiratory system ,biology.protein ,Primary immunodeficiency ,Antibody ,medicine.symptom ,business - Abstract
Background and aims Respiratory infections are expressed very soon in the life in humoral immunodeficiencies and often lead to chronic irreversible complications such as bronchiectasis and chronic airflow limitation. This study was conducted to evaluate the pulmonary complications of predominantly antibody immunodeficiencies to show the benefits of timely diagnosis and appropriate therapy. Patients and methods The information of 48 patients involved with a type of predominantly antibody immunodeficiencies, including sex, type of primary immunodeficiency, age at the onset of symptoms, age at diagnosis, recurrent infections, respiratory symptoms, and pulmonary radiological and functional abnormalities were recorded and analyzed. Results In 48 patients evaluated, the mean age at diagnosis was 25.63 years. The mean diagnostic delay was estimated to be 13.62 years. The most recurring clinical manifestations, sinusitis (69.6%), otitis (43.5%), and recurrent pneumonia were the cause of frequent admissions in 68.8% of these patients. Bronchiectasis was frequently found (58.3%) in these patients mostly involving the middle and lower lobes (48.8% and 41.5%, respectively). Conclusions Respiratory complications, infectious or non-infectious, determine the prognosis of the disease in patients with predominantly antibody immunodeficiencies. Timely diagnosis and appropriate management may improve life expectancy and the quality of life in these patients.
- Published
- 2018