Search

BACKGROUND. The use of high-throughput technologies has enabled rapid advancement in the knowledge of host immune responses to pathogens. Our objective was to compare the repertoire, protection, and maternal factors associated with human milk antibodies to infectious pathogens in different economic and geographic locations. METHODS. Using multipathogen protein microarrays, 878 milk and 94 paired serum samples collected from 695 women in 5 high and low-to-middle income countries (Bangladesh, Finland, Peru, Pakistan, and the United States) were assessed for specific IgA and IgG antibodies to 1,607 proteins from 30 enteric, respiratory, and bloodborne pathogens. RESULTS. The antibody coverage across enteric and respiratory pathogens was highest in Bangladeshi and Pakistani cohorts and lowest in the U.S. and Finland. While some pathogens induced a dominant IgA response (Campylobacter, Klebsiella, Acinetobacter, Cryptosporidium, and pertussis), others elicited both IgA and IgG antibodies in milk and serum, possibly related to the invasiveness of the infection (Shigella, enteropathogenic E. coli 'EPEC', Streptococcus pneumoniae, Staphylococcus aureus, and Group B Streptococcus). Besides the differences between economic regions and decreases in concentrations over time, human milk IgA and IgG antibody concentrations were lower in mothers with high BMI and higher parity, respectively. In Bangladeshi infants, a higher specific IgA concentration in human milk was associated with delayed time to rotavirus infection, implying protective properties of antirotavirus antibodies, whereas a higher IgA antibody concentration was associated with greater incidence of Campylobacter infection. CONCLUSION. This comprehensive assessment of human milk antibody profiles may be used to guide the development of passive protection strategies against infant morbidity and mortality. FUNDING. Bill and Melinda Gates Foundation grant OPP1172222 (to KMJ); Bill and Melinda Gates Foundation grant OPP1066764 funded the MDIG trial (to DER); University of Rochester CTSI and Environmental Health Sciences Center funded the Rochester Lifestyle study (to RJL); and R01 AI043596 funded PROVIDE (to WAP)., Introduction In 2019, 5.3 million liveborn children died before 5 years of age worldwide, nearly half of whom died from infectious diseases, including lower respiratory infections and diarrhea (1). The [...]

Hazard recognition and prevention techniques utilize augmented reality (AR) and virtual reality (VR) technology for immersive training and identification of potential hazards. Currently, no scoping reviews exist specifically on hazard recognition and prevention using AR and VR, which is crucial for forming evidence-based guidelines. This scoping review aimed to identify the use of AR and VR in hazard recognition and prevention, identify research gaps, and provide future recommendations. This Joanna Brings Institute (JBI) approach was used to investigate hazard recognition and prevention with AR and VR interventions. A total of six reliable databases were included: Google Scholar, IEEE Xplore, ACM Digital Library, PubMed, Scopus, and APA PsycNet, focusing on records and publications from the last five years. The review identified 5438 publications, with 22 meeting final inclusion criteria. The major findings include the use of AR and VR for teaching new skills, ensuring health and safety, enhancing realism, developing cognitive skills, improving performance, increasing engagement, and stimulating a sense of presence. Limitations identified include limited or non-diverse sample size, absence of real-world scenarios or contextual learning, inadequate game mechanics, insufficient validation of test results, lack of dynamic game behaviour, insufficient expert inclusion, technology issues, long-term impact assessment, and cost comparisons with traditional approaches. Technological issues have emerged as an additional impediment, limiting the efficacy of AR/VR applications in hazard recognition and prevention. In light of these findings, future research should focus on integrating contextual learning, expert inclusion, sample recruitment, expert validation, long-term impact assessment, and resolving technological challenges to enhance AR/VR applications' efficacy and real-world viability. [ABSTRACT FROM AUTHOR]

Global student mobility has reached far beyond Europe, North America, and Australia. Malaysia, Singapore, and South Korea have become the 'emerging contenders' focusing on attracting international students, primarily from other Asian countries. This heightened competition among higher education institutions (HEIs) challenges their sustainability. This study, therefore, aims to investigate Alcaide-Pulido, Alves, and Gutiérrez-Villar's university image model and its influence on students' citizenship behaviour in the context of HEIs' achieving sustainability. Data were collected from 223 international students at two reputable Malaysian universities. The results, showing that 'image' is a 'higher-order construct', extend the university image model and reveal a reformation of the 'image' variables. The findings further reveal that the extended and reformed model is capable of building satisfaction among students, which, in turn, contributes to enhancing students' citizenship behavioural outcomes (advocacy, feedback, helping behaviour, and tolerance). This can indirectly support HEIs' sustainability.

3D printing (3DP) has emerged as a disruptive manufacturing technology that benefits both the manufacturing and educational sectors. The emergence of low-cost and affordable 3D printers has facilitated the widespread use of 3DP technology, particularly in higher education institutions (HEIs) in developing countries. Despite its promising benefits, 3DP is still poorly adopted in developing countries. While research has explored the use and adoption of 3DP in education within developed nations, little research has been conducted on the integration of 3DP to capitalize on its benefits in developing countries. Therefore, in this study, we aim to investigate the perspectives of students and faculty members in higher education (HE) regarding 3DP integration in the classroom. A survey was conducted with 307 participants (272 students and 35 faculty members) at 12 Vietnamese universities where 3DP education is offered. We found that a misaligned curriculum, lack of training for faculty members, the high cost of materials and equipment, English language barriers, and limited student exposure to 3DP technology were significant obstacles to 3DP education. Several recommendations have been provided to address these challenges; for instance, faculty members and industry professionals need collaboration to ensure that the curriculum is current and that faculty members receive adequate training to teach 3DP effectively. This study provides guidelines for faculty members and policymakers to reinforce 3DP education for sustainable development in developing countries. [ABSTRACT FROM AUTHOR]

Background: Many food stores in Baghdad city suffered from a lack of the application of good hygiene practices and food safety standards in food handling that should be done regarding frozen food storage. The implementation of these standards and practices will promote the quality and safety of frozen food products and keep foods safe for consumption. Aim: The objective of this study was to evaluate frozen food product samples collected randomly from different food stores in Baghdad. Methods: Twenty frozen food products were drawn randomly from food stores in Baghdad, and both sensorial and microbial characteristics were tested at the Laboratory of Microbiology of the Market Research and Consumer Protection Center according to the accredited Iraqi standard. Results: Obtained results demonstrated that tested samples were, on average, 22,2% non-conformity with the Iraqi standard of microbiological limits in food and 55% as average non-conformity in sensorial assessment. Discussion: A high percentage of selected frozen food products failed in both microbial and sensorial analysis, and this referred to a lack of food handling practices that food stores should follow. Conclusion: Many frozen food products offered in food stores in Baghdad city are made without the application of good hygiene practices and food safety standards that are essential for food handling in food stores. [ABSTRACT FROM AUTHOR]

This study aims to classify research impact indicators based on their characteristics and scope. A concept of evidence-based nomenclature of research impact (RI) indicator has been introduced for generalization and transformation of scope.

This review paper introduces and explores the Research Impact Quintuple Helix Model, a comprehensive framework designed to analyse and enhance the impact of research across societal, economic, and environmental dimensions. Unlike traditional models focusing on sectoral collaboration for innovation and economic development, this model integrates five critical elements - Research, Publication, Researchers, Institutions, and Countries - offering a holistic approach to understanding research impact. The study systematically examines the dynamic interactions among these elements, emphasising their collective role in fostering collaborative synergies, interdisciplinary research, and effective resource allocation. By aligning research activities with broader societal needs and environmental considerations, the model aims to extend the scope of research impact beyond academic achievements, highlighting the importance of policy alignment, societal engagement, and sustainable practices. Key comparisons with the standard Helix models demonstrate the unique contributions of the research impact quintuple helix model, illustrating its potential to address specific challenges in maximising research benefits. The paper identifies strategic collaborations and policy implications that could significantly enhance the societal benefits of research, advocating for a structured integration of the model's elements into research and policymaking processes. The review concludes by recognising limitations in the existing literature and calling for empirical studies to validate and refine the model. Future research should incorporate quantitative methods to measure the impact effectively, aiming to transform theoretical insights into actionable strategies for a sustainable and impactful research ecosystem. [ABSTRACT FROM AUTHOR]

A green synthesis method for producing zinc oxide nanoparticles (ZnO NPs) was presented using natural Gum Arabic (GA) as a natural stabilizing agent. For the first time, the as-synthesized ZnO NPs were employed to photodegrade the toxic Congo Red (CR) dye in an aqueous solution. The structural and morphological characterizations confirmed the successful synthesis of ZnO NPs. The ZnO NPs possessed an average crystallite size of 42.7 nm. In addition, it was found that a concentration of 20 mg L−1 of CR dye yielded the most favorable photodegradation results, and 4 mg mL−1 of the photocatalyst was the optimal amount. The results showed a maximum degradation percentage of 99.5% at pH 8 after 30 min of irradiation. This indicates that the as-synthesized ZnO NPs have remarkable photocatalytic properties. Moreover, the study demonstrated the suitability of the pseudo-first-order kinetic model for representing the photodegradation process through kinetic studies of the photocatalyst process of CR dye by ZnO NPs using the Langmuir-Hinshelwood (L-H) model. [ABSTRACT FROM AUTHOR]

Technological interventions are increasingly popular methods of targeting and preventing loneliness in older adults. Research has identified various factors that influence the willingness and propensity of older adults to integrate technology into their social lives and the ways in which this may enhance their social connectedness. Given prevalence rates and negative outcomes associated with loneliness for this population, further research is warranted to clarify the mechanisms through which technological interventions may decrease loneliness. This study aimed to better understand the perspectives of older adults on the role of technology in their social relationships in later life. Four focus groups were conducted with 27 older adults, aged 65–80 years. Transcripts were analysed using thematic analysis, and results were validated via written participant feedback. Participants reported technology as one of many tools used to maintain their social relationships. Their choice to use technology for social interaction was influenced by their estimation of effort required, likely quality of the interaction, and the privacy and security provided. These factors were the same as those that influenced decisions to use other methods (e.g. face-to-face meetings). Based on the results, we recommend that loneliness interventions should be technology-agnostic and multifaceted, providing a wide range of tools that recognise the technological competencies of older adults and supporting different interaction types to meet the preferences of the individual. [ABSTRACT FROM AUTHOR]

Precisely tuning bicomponent intimacy during reactions by traditional methods remains a formidable challenge in the fabrication of highly active and stable catalysts because of the difficulty in constructing well‐defined catalytic systems and the occurrence of agglomeration during assembly. To overcome these limitations, a PtRuPNiO@TiOx catalyst on a Ti plate was prepared by ultrasound‐assisted low‐voltage plasma electrolysis. This method involves the oxidation of pure Ti metal and co‐reduction of strong metals at 3000°C, followed by sonochemical ultrasonication under ambient conditions in an aqueous solution. The intimacy of the bimetals in PtRuPNiO@TiOx is tuned, and the metal nanoparticles are uniformly distributed on the porous titania coating via strong metal‒support interactions by leveraging the instantaneous high‐energy input from the plasma discharge and ultrasonic irradiation. The intimacy of PtRuPNiO@TiOx increases the electron density on the Pt surface. Consequently, the paired sites exhibit a high hydrogen evolution reaction activity (an overpotential of 220 mV at a current density of 10 mA cm−2 and Tafel slope of 186 mV dec−1), excellent activity in the hydrogenation of 4‐nitrophenol with a robust stability for up to 20 cycles, and the ability to contrast stated catalysts without ultrasonication and plasma electrolysis. This study facilitates industrially important reactions through synergistic chemical interactions. [ABSTRACT FROM AUTHOR]