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8. Protein-mediated surface structuring in biomembranes

Author

Maggio B., Rosetti C.M., Borioli G.A., Fanani M.L., and Del Boca M.

Subjects
Lipid monolayers, Sphingomyelinase, c-Fos, Segregated lipid domains, Lipid-protein interaction, Anphitropic proteins, Medicine (General), R5-920, Biology (General), QH301-705.5
Abstract

The lipids and proteins of biomembranes exhibit highly dissimilar conformations, geometrical shapes, amphipathicity, and thermodynamic properties which constrain their two-dimensional molecular packing, electrostatics, and interaction preferences. This causes inevitable development of large local tensions that frequently relax into phase or compositional immiscibility along lateral and transverse planes of the membrane. On the other hand, these effects constitute the very codes that mediate molecular and structural changes determining and controlling the possibilities for enzymatic activity, apposition and recombination in biomembranes. The presence of proteins constitutes a major perturbing factor for the membrane sculpturing both in terms of its surface topography and dynamics. We will focus on some results from our group within this context and summarize some recent evidence for the active involvement of extrinsic (myelin basic protein), integral (Folch-Lees proteolipid protein) and amphitropic (c-Fos and c-Jun) proteins, as well as a membrane-active amphitropic phosphohydrolytic enzyme (neutral sphingomyelinase), in the process of lateral segregation and dynamics of phase domains, sculpturing of the surface topography, and the bi-directional modulation of the membrane biochemical reactivity.

Published
2005

10. Monitoring of the radio galaxy M 87 during a low-emission state from 2012 to 2015 with MAGIC

Author

Acciari, V A, Ansoldi, Antonelli, S, L A, Arbet&nbsp, Engels, Arcaro, A, Baack, C, Babić, D, Banerjee, A, Bangale, B, Barres&nbsp, de&nbsp, Almeida, P, Barrio, U, J A, Becerra&nbsp, González, Bednarek, J, Bellizzi, W, Bernardini, L, Berti, E, Besenrieder, A, Bhattacharyya, J, Bigongiari, W, Biland, C, Blanch, A, Bonnoli, O, Bošnjak, G, Busetto, Ž, Carosi, G, Ceribella, R, Chai, G, Chilingaryan, Y, Cikota, A, Colak, S, S M, Colin, Colombo, U, Contreras, E, J L, Cortina, Covino, J, D’Elia, S, Da&nbsp, Vela, V, Dazzi, P, De&nbsp, Angelis, F, Lotto, A, Delfino, B, Delgado, M, Depaoli, J, Di&nbsp, Pierro, D, Venere, F, Do&nbsp, Souto&nbsp, Espiñeira, L, Dominis&nbsp, Prester, E, Donini, D, Dorner, A, Doro, D, Elsaesser, M, Fallah&nbsp, Ramazani, D, Fattorini, V, Fernández-Barral, A, Ferrara, A, Fidalgo, G, Foffano, D, Fonseca, L, M V, Font, Fruck, L, Fukami, C, García&nbsp, López, S, R J, Garczarczyk, Gasparyan, M, Gaug, S, Giglietto, M, Giordano, N, Godinović, F, Green, N, Guberman, D, Hadasch, D, Hahn, D, Herrera, A, Hoang, J, Hrupec, J, Hütten, D, Inada, M, Inoue, T, Ishio, S, Iwamura, K, Jouvin, Y, Kerszberg, L, Kubo, D, Kushida, H, Lamastra, J, Lelas, A, D, Leone, F., Lindfors, E., Lombardi, Longo, S, López, F, López-Coto, M, López-Oramas, R, Loporchio, A, Machado&nbsp, Oliveira&nbsp, Fraga, S, Maggio, B, Majumdar, C, Makariev, P, Mallamaci, M, Maneva, M, Manganaro, G, Mannheim, M, Maraschi, K, Mariotti, L, Martínez, M, Masuda, M, Mazin, S, Mićanović, D, Miceli, S, Minev, D, Miranda, M, J M, Mirzoyan, Molina, R, Moralejo, E, Morcuende, A, Moreno, D, Moretti, V, Munar-Adrover, E, Neustroev, P, Nigro, V, Nilsson, C, Ninci, K, Nishijima, D, Noda, K, Nogués, K, Nöthe, L, Nozaki, M, Paiano, S, Palacio, S, Palatiello, J, Paneque, M, Paoletti, D, Paredes, R, Peñil, Peresano, P, Persic, M, Prada&nbsp, Moroni, M, P G, Prandini, Puljak, E, Rhode, I, Ribó, W, Rico, M, Righi, J, Rugliancich, C, Saha, A, Sahakyan, L, Saito, N, Sakurai, T, Satalecka, S, Schmidt, K, Schweizer, K, Sitarek, T, Šnidarić, J, Sobczynska, I, Somero, D, Stamerra, A, Strom, A, Strzys, D, Suda, M, Surić, Y, Takahashi, T, Tavecchio, M, Temnikov, F, Terzić, P, Teshima, T, Torres-Albà, M, Tosti, N, Tsujimoto, L, Vagelli, S, van&nbsp, Scherpenberg, V, Vanzo, J, Acosta, G, M Vazquez, Vigorito, C F, Vitale, Vovk, V, Will, I, Zarić, M, Asano, D, Collaborators: K, Hada, Harris, K, D E, Giroletti, Jermak, M, H E, Madrid, J P, Massaro, Richter, F, Spanier, S, Steele, F, I A, Walker, R, C, European Space Agency, Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), National Aeronautics and Space Administration (US), Agencia Estatal de Investigación (España), European Commission, Acciari, V. A., Ansoldi, S., Antonelli, L. A., Arbet Engels, A., Arcaro, C., Baack, D., Babic, A., Banerjee, B., Bangale, P., Barres de Almeida, U., Barrio, J. A., Becerra Gonzalez, J., Bednarek, W., Bellizzi, L., Bernardini, E., Berti, A., Besenrieder, J., Bhattacharyya, W., Bigongiari, C., Biland, A., Blanch, O., Bonnoli, G., Bosnjak, Z., Busetto, G., Carosi, R., Ceribella, G., Chai, Y., Chilingaryan, A., Cikota, S., Colak, S. M., Colin, U., Colombo, E., Contreras, J. L., Cortina, J., Covino, S., D'Elia, V., da Vela, P., Dazzi, F., de Angelis, A., de Lotto, B., Delfino, M., Delgado, J., Depaoli, D., Di Pierro, F., Di Venere, L., Do Souto Espineira, E., Dominis Prester, D., Donini, A., Dorner, D., Doro, M., Elsaesser, D., Fallah Ramazani, V., Fattorini, A., Fernandez-Barral, A., Ferrara, G., Fidalgo, D., Foffano, L., Fonseca, M. V., Font, L., Fruck, C., Fukami, S., Garcia Lopez, R. J., Garczarczyk, M., Gasparyan, S., Gaug, M., Giglietto, N., Giordano, F., Godinovic, N., Green, D., Guberman, D., Hadasch, D., Hahn, A., Herrera, J., Hoang, J., Hrupec, D., Hutten, M., Inada, T., Inoue, S., Ishio, K., Iwamura, Y., Jouvin, L., Kerszberg, D., Kubo, H., Kushida, J., Lamastra, A., Lelas, D., Leone, F., Lindfors, E., Lombardi, S., Longo, F., Lopez, M., Lopez-Coto, R., Lopez-Oramas, A., Loporchio, S., Machado de Oliveira Fraga, B., Maggio, C., Majumdar, P., Makariev, M., Mallamaci, M., Maneva, G., Manganaro, M., Mannheim, K., Maraschi, L., Mariotti, M., Martinez, M., Masuda, S., Mazin, D., Micanovic, S., Miceli, D., Minev, M., Miranda, J. M., Mirzoyan, R., Molina, E., Moralejo, A., Morcuende, D., Moreno, V., Moretti, E., Munar-Adrover, P., Neustroev, V., Nigro, C., Nilsson, K., Ninci, D., Nishijima, K., Noda, K., Nogues, L., Nothe, M., Nozaki, S., Paiano, S., Palacio, J., Palatiello, M., Paneque, D., Paoletti, R., Paredes, J. M., Penil, P., Peresano, M., Persic, M., Prada Moroni, P. G., Prandini, E., Puljak, I., Rhode, W., Ribo, M., Rico, J., Righi, C., Rugliancich, A., Saha, L., Sahakyan, N., Saito, T., Sakurai, S., Satalecka, K., Schmidt, K., Schweizer, T., Sitarek, J., Snidaric, I., Sobczynska, D., Somero, A., Stamerra, A., Strom, D., Strzys, M., Suda, Y., Suric, T., Takahashi, M., Tavecchio, F., Temnikov, P., Terzic, T., Teshima, M., Torres-Alba, N., Tosti, L., Tsujimoto, S., Vagelli, V., van Scherpenberg, J., Vanzo, G., Vazquez Acosta, M., Vigorito, C. F., Vitale, V., Vovk, I., Will, M., Zaric, D., Asano, K., Hada, K., Harris, D. E., Giroletti, M., Jermak, H. E., Madrid, J. P., Massaro, F., Richter, S., Spanier, F., Steele, I. A., Walker, R. C., 30588766 - Arcaro, Cornelia, 25433822 - Richter, Stephan, and 25161814 - Spanier, Felix Alexander

Subjects
galaxies [Gamma rays], Photon, Radio galaxy, VHE [gamma ray], radiation mechanisms non-thermal, galaxies active, galaxies individual M 87, galaxies jets, gamma rays galaxies, magnetic field, Astrophysics, jet [Galaxies], 01 natural sciences, Power law, law.invention, galaxies: individual: M 87, law, flux [gamma ray], radiation mechanisms: non-thermal, galaxies: active, galaxies: jets, gamma rays: galaxies, Astrophysics - High Energy Astrophysical Phenomena, 010303 astronomy & astrophysics, QC, QB, High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, Physics, galaxie [Gamma rays], photon, Synchrotron, Magnetic field, Wavelength, Galaxies: active, Galaxies: individual: M 87, Galaxies: jets, Gamma rays: galaxies, Radiation mechanisms: non-thermal, Spectral energy distribution, Astrophysics and Astronomy, active [Galaxies], Astrophysics::High Energy Astrophysical Phenomena, radio wave [galaxy], FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, GLAST, GeneralLiterature_MISCELLANEOUS, Telescope, emission [gamma ray], synchrotron, 0103 physical sciences, Astrophysics::Galaxy Astrophysics, non-thermal [Radiation mechanisms], hybrid, 010308 nuclear & particles physics, ComputingMilieux_PERSONALCOMPUTING, individual: M 87 [galaxies], Astronomy and Astrophysics, MAGIC, monitoring, Space and Planetary Science, ddc:520, spectral, jets [Galaxies], individual: M 87 [Galaxies], non-thermal [adiation mechanisms]
Abstract

MAGIC Collaboration: et al., M 87 is one of the closest (z = 0.004 36) extragalactic sources emitting at very high energies (VHE, E > 100 GeV). The aim of this work is to locate the region of the VHE gamma-ray emission and to describe the observed broad-band spectral energy distribution (SED) during the low VHE gamma-ray state. The data from M 87 collected between 2012 and 2015 as part of a MAGIC monitoring programme are analysed and combined with multiwavelength data from Fermi-LAT, Chandra, HST, EVN, VLBA, and the Liverpool Telescope. The averaged VHE gamma-ray spectrum can be fitted from ∼100 GeV to ∼10 TeV with a simple power law with a photon index of (−2.41 ± 0.07), while the integral flux above 300 GeV is (1.44±0.13)×10−12cm−2s−1⁠. During the campaign between 2012 and 2015, M 87 is generally found in a low-emission state at all observed wavelengths. The VHE gamma-ray flux from the present 2012–2015M 87 campaign is consistent with a constant flux with some hint of variability (⁠∼3σ⁠) on a daily time-scale in 2013. The low-state gamma-ray emission likely originates from the same region as the flare-state emission. Given the broad-band SED, both a leptonic synchrotron self-Compton and a hybrid photohadronic model reproduce the available data well, even if the latter is preferred. We note, however, that the energy stored in the magnetic field in the leptonic scenario is very low, suggesting a matter-dominated emission region., The financial support of the German BMBF and MPG, the Italian Istituto Nazionale di Fisica Nucleare (INFN) and Istituto Nazionale di Astrofisica (INAF), the Swiss National Fund (SNF), the ERDF under the Spanish Ministry of Economy and Competitiveness (MINECO) (FPA2015-69818-P, FPA2012-36668, FPA2015-68378-P, FPA2015-69210-C6-2-R, FPA2015-69210-C6-4-R, FPA2015-69210-C6-6-R, AYA2015-71042-P, AYA2016-76012-C3-1-P, ESP2015-71662-C2-2-P, FPA2017-90566-REDC), the Indian Department of Atomic Energy, the Japanese JSPS and MEXT, and the Bulgarian Ministry of Education and Science, National RI Roadmap Project DO1-153/28.08.2018, is gratefully acknowledged. This work was also supported by the Spanish Centro de Excelencia ‘Severo Ochoa’ SEV-2016-0588 and SEV2015-0548, and Unidad de Excelencia ‘Maria de Maeztu’ MDM2014-0369, by the Croatian Science Foundation (HrZZ) Project IP-2016-06-9782 and the University of Rijeka Project 13.12.1.3.02, by the DFG Collaborative Research Centers grants SFB823/C4 and SFB876/C3, by the Polish National Research Centre grant UMO2016/22/M/ST9/00382, and by the Brazilian MCTIC, CNPq, and FAPERJ. The Very Long Baseline Array is operated by the National Radio Astronomy Observatory, which is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. The work of FM is supported by the ‘Departments of Excellence 2018–2022’ Grant awarded by the Italian Ministry of Education, University and Research (MIUR) (L. 232/2016). His research has made also use of resources provided by the Compagnia di San Paolo for the grant awarded on the BLENV project (S1618 L1 MASF 01) and by the Ministry of Education, Universities and Research for the grant MASF FFABR 17 01. This investigation is supported by the National Aeronautics and Space Administration (NASA) grants GO4-15096X, AR6-17012X, and GO6-17081X. This work made use of the Swinburne University of Technology software correlator, developed as part of the Australian Major National Research Facilities Programme and operated under licence. Based in part on observations made with the NASA/European Space Agency (ESA) Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555. These observations are associated with programmes GO 12293, 12671, 13061, and 13759.

Published
2020

11. Second primary neoplasms in patients with lung and gastroenteropancreatic neuroendocrine neoplasms: Data from a retrospective multi-centric study

Author

Massironi, S., Campana, D., Pusceddu c, S., Albertelli, M., Faggiano e, A., Panzuto f, F., Smiroldo g, V., Andreasi h, V., Rossi i, R. E., Maggio b, I., Torchio c, M., Dotto, A., Modica j, R., Rinzivillo f, M., Carnaghi k, C., Partelli h, S., Fanetti l, I., Lamberti b, G., Corti c, F., Ferone, D., Colao j, A., Annibale f, B., M, Invernizzi a, P., Falconi h, M., and ItaNet (Italian Association for Neuroendocrine Tumours) Study Group

Published
2020

14. Synthesized benzamido derivatives exert antiproliferative effects by DNA damage and ROS generation

Author

D’Anneo, A., Raffa, D., Plescia, F., Maggio, B., Raimondi, M., Daidone, G., Lauricella, M., D’Anneo, A, Raffa, D, Plescia, F, Maggio, B, Raimondi, MV, Daidone, G, and Lauricella, M.

Subjects
anti-proliferative effect, DNA damage, benzamido derivatives, ROS, anti-proliferative effects
Abstract

In this study we explored the effect and the biological action of synthesized benzamido derivatives bearing the (1S,2S)-2-phenyl-cyclopropane-1-carboxamido, 1,1'-biphen-2-carboxamido and 1,1'-biphen-4-carboxamido moieties on K562, a human leukemia cell line. Among the synthesized compounds a particular antiproliferative action was observed with the benzamido derivative bearing the 2-1,1'-biphenyl moiety with the substitution at the 5 position of the benzamido moiety with iodine. This compound showed cytotoxic effects in K562 leukemic cells at nanomolar concentrations and was, therefore, chosen as compound to explore its mode of action. Our analyses provided evidence that this benzamido derivative induced a reduction in cell number and volume with the appearance of a shrunken cytoplasm at 24h, followed by a widespread cell fragmentation at 48h. As demonstrated by flow cytometry analyses, the effect was dose- and time-dependent, causing a G2/M cell cycle arrest in the first phase of treatment (24h), followed by an apoptotic death at 48h (IC50 0.5 μM ). The elucidation of the underlying mechanism also disclosed that DNA arrest in G2/M phase of cell cycle was consequent to DNA lesions, since an increase in phospho-ATM and yH2AX, two known markers of DNA repair response system, was observed. Prolonging the time of treatment, the effects, which were observed only in leukaemic cells but not in normal bronchial epithelial cells, were accompanied by ROS production, JNK phosphorylation and induction of a caspase-dependent apoptosis.

Published
2016

15. A Multicentric Prospective Incidence Study of Guillain-Barré Syndrome in Italy. The ITANG Study

Author

Benedetti, M, Pugliatti, M, Dalessandro, R, BEGHI, ETTORE, Chiò, A, Logroscino, G, Filippini, G, Galeotti, F, Massari, M, Santuccio, C, Raschetti, R, Abruzzi, L, Agazzi, E, Agostoni, E, Ambrogio, L, Amidei, S, Arbasino, C, Argentiero, V, Arnaboldi, M, Baldini, D, Barki, R, Bassi, P, Basso, F, Belcastro, V, Bellotti, M, Bersano, E, Besana, R, Bettoni, L, Bezzi, G, Bianconi, C, Bondavalli, M, Bonometti, A, Borghi, AM, Borsato, C, Bortolotto, S, Bottacchi, EF, Bresolin, N, Bruno, S, Burlina, A, Cafasso, G, Callegarini, C, Calvo, A, Candeloro, E, Casano, A, Cattaneo, SI, Cavallo, R, Cheldi, A, Ciardo, G, Cirignotta, F, Clerici, AM, Clerici, R, Comi, G, Conti, R, Coppo, F, Covelli, V, Crespi, V, Currò Dossi, M, Curtò, NA, D'Adda, E, Dallocchio, C, D'Anna, S, De Massis, P, De Toni Franceschini, L, Di Vito, N, Didonè, G, Dileone, M, Donati, E, Dotta, M, Fazio, R, Federico, F, FERRARESE, CARLO, Ferrazzini, F, Ferrero, B, Filosto, M, Frasson, E, Fusina, S, Galbussera, A, Gastaldo, E, Geda, C, Ghiglione, P, Giometto, B, Gionco, M, Giorgetti, A, Giussani, G, Gobbin, F, Grampa, G, Granieri, E, Greco, G, Guidetti, D, Guidi, C, Guidotti, M, Gusmaroli, G, Imperiale, D, Internò, S, Jann, S, La Spina, I, Leo, A, Leone, M, Leoni, S, Leotta, D, Lerario, R, Liotta, G, Livrea, P, Luda di Cortemiglio, E, Maggio, B, Magni, E, Magnoni, A, Maistrelli, J, Manca, D, Mandrioli, J, Manera, U, Marcello, N, Marchi, P, Marchini, C, Marconi, S, Mattioli, M, Mauro, A, Mazzaglia, G, Medici, D, Meineri, P, Meola, G, Micaglio, G, Michelucci, R, Michieli, G, Micieli, G, Minardi, C, Moglia, C, Monaco, S, Montanari, E, Moretto, G, Munerati, V, Mura, G, Mussutto, V, Nascimbene, C, Neri, W, Nichelli, P, Nobile Orazio, E, Oddenino, E, Onorato, S, Padovani, A, Palermo, M, Papurello, DM, Passarella, B, Pavesi, G, Penza, MT, Perini, M, Perini, F, Perla, F, Perlotto, N, Perrone, P, Pignatta, P, Pisano, F, Poglio, F, Polo, A, Poloni, M, Porazzi, D, Pradotto, L, Previdi, P, Quatrale, R, Rasi, F, Ravasio, A, Ravetti, C, Repaci, M, Riccardi, T, Riguzzi, P, Rinaldi, R, Riva, M, Romeo, V, Romorini, A, Rosso, T, Rotondo, G, Sacquegna, T, Sanson, F, Santamato, V, Santoro, D, Sartori, V, Sasanelli, F, Savio, K, Serena, M, Silani, V, Silvestri, L, Simioni, V, Squintani, GM, Suardelli, M, Tartagla, L, Terenghi, F, Terlizzi, E, Terzano, M, Tesser, F, Testa, L, Ticca, A, Ticozzi, N, Tiriticco, M, Tola, MR, Tonietti, S, Trianni, G, Trojano, M, Trotta, F, Turatti, M, Ursino, E, Vanotti, A, Vercellino, M, Villani, A, Vitelli, E, Zambito Marsala, S, Zanette, G, Zarcone, D, Zimatore, G, Zoccolella, S., Benedetti, Md, Pugliatti, M, D'Alessandro, R, Beghi, E, Chiò, A, Logroscino, G, Filippini, G, Galeotti, F, Massari, M, Santuccio, C, Comi, Giancarlo, Raschetti, R, ITANG Study, Group, Giometto, B, Benedetti, M, Dalessandro, R, Abruzzi, L, Agazzi, E, Agostoni, E, Ambrogio, L, Amidei, S, Arbasino, C, Argentiero, V, Arnaboldi, M, Baldini, D, Barki, R, Bassi, P, Basso, F, Belcastro, V, Bellotti, M, Bersano, E, Besana, R, Bettoni, L, Bezzi, G, Bianconi, C, Bondavalli, M, Bonometti, A, Borghi, A, Borsato, C, Bortolotto, S, Bottacchi, E, Bresolin, N, Bruno, S, Burlina, A, Cafasso, G, Callegarini, C, Calvo, A, Candeloro, E, Casano, A, Cattaneo, S, Cavallo, R, Cheldi, A, Ciardo, G, Cirignotta, F, Clerici, A, Clerici, R, Comi, G, Conti, R, Coppo, F, Covelli, V, Crespi, V, Currò Dossi, M, Curtò, N, D'Adda, E, Dallocchio, C, D'Anna, S, De Massis, P, De Toni Franceschini, L, Di Vito, N, Didonè, G, Dileone, M, Donati, E, Dotta, M, Fazio, R, Federico, F, Ferrarese, C, Ferrazzini, F, Ferrero, B, Filosto, M, Frasson, E, Fusina, S, Galbussera, A, Gastaldo, E, Geda, C, Ghiglione, P, Gionco, M, Giorgetti, A, Giussani, G, Gobbin, F, Grampa, G, Granieri, E, Greco, G, Guidetti, D, Guidi, C, Guidotti, M, Gusmaroli, G, Imperiale, D, Internò, S, Jann, S, La Spina, I, Leo, A, Leone, M, Leoni, S, Leotta, D, Lerario, R, Liotta, G, Livrea, P, Luda di Cortemiglio, E, Maggio, B, Magni, E, Magnoni, A, Maistrelli, J, Manca, D, Mandrioli, J, Manera, U, Marcello, N, Marchi, P, Marchini, C, Marconi, S, Mattioli, M, Mauro, A, Mazzaglia, G, Medici, D, Meineri, P, Meola, G, Micaglio, G, Michelucci, R, Michieli, G, Micieli, G, Minardi, C, Moglia, C, Monaco, S, Montanari, E, Moretto, G, Munerati, V, Mura, G, Mussutto, V, Nascimbene, C, Neri, W, Nichelli, P, Nobile Orazio, E, Oddenino, E, Onorato, S, Padovani, A, Palermo, M, Papurello, D, Passarella, B, Pavesi, G, Penza, M, Perini, M, Perini, F, Perla, F, Perlotto, N, Perrone, P, Pignatta, P, Pisano, F, Poglio, F, Polo, A, Poloni, M, Porazzi, D, Pradotto, L, Previdi, P, Quatrale, R, Rasi, F, Ravasio, A, Ravetti, C, Repaci, M, Riccardi, T, Riguzzi, P, Rinaldi, R, Riva, M, Romeo, V, Romorini, A, Rosso, T, Rotondo, G, Sacquegna, T, Sanson, F, Santamato, V, Santoro, D, Sartori, V, Sasanelli, F, Savio, K, Serena, M, Silani, V, Silvestri, L, Simioni, V, Squintani, G, Suardelli, M, Tartagla, L, Terenghi, F, Terlizzi, E, Terzano, M, Tesser, F, Testa, L, Ticca, A, Ticozzi, N, Tiriticco, M, Tola, M, Tonietti, S, Trianni, G, Trojano, M, Trotta, F, Turatti, M, Ursino, E, Vanotti, A, Vercellino, M, Villani, A, Vitelli, E, Zambito Marsala, S, Zanette, G, Zarcone, D, Zimatore, G, and Zoccolella, S

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Epidemiology, Population, Guillain-Barre Syndrome, Rate ratio, NO, Young Adult, Axonal and demyelinating GBS, Guillain-Barré syndrome, Incidence, Prospective study, Trend, Neurology (clinical), Aged, Aged, 80 and over, Female, Humans, Italy, Middle Aged, 80 and over, medicine, Young adult, education, Prospective cohort study, education.field_of_study, Guillain-Barre syndrome, business.industry, Medicine (all), Incidence (epidemiology), medicine.disease, Vaccination, Settore MED/26 - NEUROLOGIA, business, Human
Abstract

Background: To assess Guillain-Barré syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS. Methods: All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions. Results: We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01). Conclusions: In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.

Published
2015

16. Synthesis and antirpoliferative activity of isoxazolo[3,4-d]pyridazin-7(6H)-one derivatives

Author

Maggio, B., Cancemi, G., Raimondi, M., Plescia, F., Cascioferro, S., Cusimano, M., Lauricella, M., Carlisi, D., Daidone, G., Raffa, D., Maggio, B, Cancemi, G, Raimondi, MV, Plescia, F, Cascioferro, SM, Cusimano, MG, Lauricella, M, Carlisi, D, Daidone, G, and Raffa, D

Subjects
Settore BIO/10 - Biochimica, isoxazolo[3,4-d]pyridazin-7(6H)-ones, antiproliferative activity, DNA interaction, Settore CHIM/08 - Chimica Farmaceutica
Abstract

3,4-diphenylisoxazolo[3,4-d]pyridazin-7(6H)-one analogs were synthesized and tested for the antiproliferative activity. Study on the cell cycle alteration and on some cellular target (ATM, procaspase-2 proteins and H2AX histone) demonstrate the increase of the cell population in S phase and to induce cellular death by apoptosis by DNA damage with double strand breaks.

Published
2014

24. Micron-scale phase segregation in lipid monolayers induced by myelin basic protein in the presence of a cholesterol analog

Author

Rosetti, C.M., Maggio, B., and Wilke, N.

Subjects
*PHASE partition, *MONOMOLECULAR films, *BILAYER lipid membranes, *CELL separation, *MYELIN basic protein, *CHOLESTEROL, *PHASE diagrams, *ELECTROLYTES
Abstract

Abstract: It was previously shown that myelin basic protein (MBP) can induce phase segregation in whole myelin monolayers and myelin lipid films, which leads to the accumulation of proteins into a separate phase, segregated from a cholesterol-enriched lipid phase. In this work we investigated some factors regulating the phase segregation induced by MBP using fluorescent microscopy of monolayers formed with binary and ternary lipid mixtures of dihydrocholesterol (a less-oxidable cholesterol analog) and phospholipids. The influence of the addition of salts to the subphase and of varying the lipid composition was analyzed. Our results show that MBP can induce a dihydrocholesterol-dependent segregation of phases that can be further regulated by the electrolyte concentration in the subphase and the composition (type and proportion) of non-sterol lipids. In this way, changes of the lipid composition of the film or the ionic strength in the aqueous media modify the local surface density of MBP and the properties (phase state and composition) of the protein environment. [Copyright &y& Elsevier]

Published
2010
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30. ChemInform Abstract: Synthesis, Benzodiazepine Receptor Binding and Molecular Modelling of Isochromeno[4,3-c]pyrazol-5(1H)-one Derivatives.

Author

Maggio, B., Raffa, D., Raimondi, M. V., Plescia, F., Trincavelli, M. L., Martini, C., Meneghetti, F., Basile, L., Guccione, S., and Daidone, G.

Abstract

A series of isochromeno[4,3-c]pyrazol-5(1H)-one derivatives (III) is prepared and tested for their ability to displace specific [3H]flunitrazepam from bovine brain membranes. [ABSTRACT FROM AUTHOR]

Published
2012
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46. Rheological properties of regular insulin and aspart insulin Langmuir monolayers at the air/water interface: Condensing effect of Zn2+ in the subphase.

Author

Grasso, E.J., Oliveira, R.G., and Maggio, B.

Subjects
*RHEOLOGY, *INSULIN resistance, *MONOMOLECULAR films, *AIR-water interfaces, *ZINC ions, *INTERFACES (Physical sciences), *VISCOELASTICITY
Abstract

Highlights: [•] The interfacial behavior or regular and aspart insulin films were described. [•] Zn2+ ions in the subphase induced different condensing effects of insulin monolayers. [•] The condensing effects are related to different viscoelastic properties. [•] The response to perturbation was mainly dilatational for all monolayers. [•] In the presence of Zn2+ a shear response was observed, being higher for regular insulin. [Copyright &y& Elsevier]

Published
2014
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47. Clinical study investigating abrasive effects of three toothpastes and water in an in situ model

Author

Macdonald, E., North, A., Maggio, B., Sufi, F., Mason, S., Moore, C., Addy, M., and West, N.X.

Subjects
*TOOTHPASTE, *MECHANICAL behavior of materials, *DENTIN, *ORAL hygiene, *CROSSOVER trials, *DENTISTRY
Abstract

Abstract: Objectives: This in situ study compared the abrasive effect of repeated brushings (over 10 days) of a low relative abrasive dentine (RDA) toothpaste with moderate and high relative abrasive dentine (RDA) toothpastes, on human dentine in situ. Materials and methods: The study design was single centre, single blind, randomized, split mouth, two period, four-treatment cross-over, in situ study in 20 healthy subjects. Subjects wore bi-lateral lower buccal appliances each fitted with four dentine sections with treatment applied with a power toothbrush, during each 10 day study period. Samples were measured at baseline, day 5 and day 10 by contact profilometry, and baseline and day 10 with non-contact profilometry. Results: Nineteen subjects were included in the efficacy analysis. Results as measured by contact and non-contact profilometry from brushing with the moderate RDA paste and high RDA paste showed significantly (p <0.0001) more abrasion to dentine than brushing with the low RDA paste or water after 10 days. Dentine loss following tooth brushing with the low RDA paste was not significantly different from brushing with water, after 10 days. Conclusions: The methodology successfully showed clear differentiation between the amount of dentine lost following toothbrushing with the low RDA paste compared to the moderate or high RDA pastes. Dentine loss following brushing with the low RDA paste showed a comparable degree of abrasion to brushing with water. [Copyright &y& Elsevier]

Published
2010
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48. The Folch–Lees proteolipid induces phase coexistence and transverse reorganization of lateral domains in myelin monolayers

Author

Rosetti, C.M., Oliveira, R.G., and Maggio, B.

Subjects
*MYELIN sheath, *NERVE tissue proteins, *LIPIDS, *BIOMOLECULES
Abstract

Abstract: Solvent solubilized myelin membranes spread as monomolecular layers at the air–water interface show a heterogeneous pattern at all surface pressures. In order to asses the role of myelin protein and lipid components in the surface structuring we compared the topography, as seen by Brewster angle microscopy (BAM) and epifluorescence microscopy, of monolayers made from mixtures containing all myelin lipids (except gangliosides) and variable proportions of Folch–Lees proteolipid protein (PLP, the major protein component of myelin). The presence of the single PLP, in the absence of the other myelin proteins, can reproduce the surface pattern of the whole myelin extract films in a concentration-dependant manner. Moreover, a threshold mole fraction of PLP is necessary to induce the lipid–protein component reorganization leading to the appearance of a rigid (gray) phase, acting as a surface skeleton, at low surface pressures and of fractal clusters at high surface pressures. The average size of those clusters is also dependent on the PLP content in the monolayer and on the time elapsed from the moment of film spreading, as they apparently result from an irreversible lateral aggregation process. The transverse rearrangement of the monolayer occurring under compression was different in films with the highest and lowest PLP mole fractions tested. [Copyright &y& Elsevier]

Published
2005
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50. Sound-Induced Flash Illusions Support Cortex Hyperexcitability in Fibromyalgia

Author

Vincenzo Di Stefano, Salvatore Iacono, Andrea Gagliardo, Bruna Maggio, Giuliana Guggino, Massimo Gangitano, Roberto Monastero, Vito Renato Maggio, Nadia Bolognini, Filippo Brighina, Di Stefano, Vincenzo, Iacono, Salvatore, Gagliardo, Andrea, Maggio, Bruna, Guggino, Giuliana, Gangitano, Massimo, Monastero, Roberto, Maggio, Vito Renato, Bolognini, Nadia, Brighina, Filippo, Di Stefano, V, Iacono, S, Gagliardo, A, Maggio, B, Guggino, G, Gangitano, M, Monastero, R, Maggio, V, Bolognini, N, and Brighina, F

Subjects
Adult, Fibromyalgia, Article Subject, Migraine Disorders, Infant, Newborn, Anxiety, Middle Aged, Illusions, Anesthesiology and Pain Medicine, Neurology, Illusion, Migraine Disorder, Acoustic Stimulation, Auditory Perception, Humans, Settore MED/26 - Neurologia, Female, Photic Stimulation, Human
Abstract

Objectives. Fibromyalgia (FM) is characterized by spontaneous chronic widespread pain in combination with hyperalgesia to pressure stimuli. Sound-induced flash illusions (SIFIs) reflect cross-modal interactions between senses allowing to assess a visual cortical hoerexcitability (VCH) by evaluating the fission and fusion illusions disruption. The aims of the present study were to explore whether SIFIs are perceived differently in patients with fibromyalgia as compared to healthy controls (HCs) and how migraine affects fission and fusion illusions in fibromyalgia. Methods. A single flash (F) accompanied by 0 to 4 beeps (B) was presented to induce the fission illusion while multiple flash (i.e., 2 to 4) accompanied by 0 or 1 beep was presented to induce fusion illusion. The mean number of perceived flashes in fission and fusion illusion trials was compared between the groups (i.e., FM, FM with migraine, and HCs) using repeated-measures analysis of variance. Medication history was recorded along with the administration of Fibromyalgia Impact Questionnaire and Hospital Anxiety and Depression scales. Results. Twenty-four patients with FM (mean age 51, 2 ± 10, 6 years; 22 females), seventeen patients with FM and migraine without aura (mean age 47.8 ± 11.4 years; 16 females; 13 chronic, 4 episodic migraine), and forty-one age- and sex-matched HCs (mean age 47.3 ± 6.9 years; 34 females) participated in the study. Fission and fusion illusory effects were detected in all the participants. However, in FM patients, the fission illusion was reduced and almost abolished as compared to HCs (1F1B, p = 0.02 ; 1F2B, p < 0.0001 ; 1F3B, p < 0.0001 ; 1F4B, p = 0.0001 ), while there were no differences between groups in fusion trials. Migraine did not affect the fission and the fusion illusions. Conclusion. Results from this study confirm that patients with FM have a VCH suggesting that the pathological changes in cortical excitability might have important roles in the pathophysiology of FM. SIFI represents a noninvasive behavioral tool for the exploration of cross-sensory functional interplay.

Published
2022
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