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319 results on '"Maeda, Norikazu"'

3. Myocardial fat accumulation is associated with cardiac dysfunction in patients with type 2 diabetes, especially in elderly or female patients: a retrospective observational study

Author

Kashiwagi-Takayama, Risa, Kozawa, Junji, Hosokawa, Yoshiya, Kato, Sarasa, Kawata, Satoshi, Ozawa, Harutoshi, Mineo, Ryohei, Ishibashi, Chisaki, Baden, Megu Y., Iwamoto, Ryuya, Saisho, Kenji, Fujita, Yukari, Tamba, Sachiko, Sugiyama, Takuya, Nishizawa, Hitoshi, Maeda, Norikazu, Yamamoto, Koji, Higashi, Masahiro, Yamada, Yuya, Sakata, Yasushi, Matsuzawa, Yuji, and Shimomura, Iichiro

Published
2023
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7. Food Preference Assessed by the Newly Developed Nutrition-Based Japan Food Preference Questionnaire and Its Association with Dietary Intake in Abdominal-Obese Subjects.

Author

Nagai, Naoko, Fujishima, Yuya, Tokuzawa, Chie, Takayanagi, Satoko, Yamamoto, Mikiko, Hara, Tomoyuki, Kimura, Yu, Nagao, Hirofumi, Obata, Yoshinari, Fukuda, Shiro, Baden, Megu Y., Kozawa, Junji, Maeda, Norikazu, Nishizawa, Hitoshi, and Shimomura, Iichiro

Abstract

Background/Objectives: Understanding food preferences is important for weight management. However, methods for assessing food preferences are not well established, especially in Japan. This study aimed to examine detailed food preferences and their associations with actual food intake in non-obese and abdominal-obese subjects using a newly developed questionnaire tailored for the Japanese population. Methods: We developed the Japan Food Preference Questionnaire (JFPQ) to evaluate food preferences across four nutrient groups based on nutritional evidence: carbohydrate, fat, protein, and dietary fiber. A total of 38 non-obese and 30 abdominal-obese participants completed both the JFPQ and the Food Frequency Questionnaire (FFQ). Food preferences for each nutrient were compared between the two groups, and correlations between food preferences (assessed by the JFPQ) and food intake (assessed by the FFQ) were analyzed. Results: Compared with the non-obese group, the abdominal-obese group showed significantly greater preferences for carbohydrates, fat, and protein, with no significant difference in dietary fiber after adjusting for age and sex. Furthermore, in the abdominal-obese group, positive correlations were found between actual intake and preference for high-fat and high-carbohydrate foods. Conclusions: Our findings from this pilot study demonstrated that abdominal-obese individuals had greater preferences for fat and carbohydrates, which were linked to actual fat and carbohydrate intake and possibly contributed to the development of obesity. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome

Author

Kita, Shunbun, Maeda, Norikazu, Shimomura, Lichiro, and Philipp E. Scherer

Subjects
Physiological aspects, International economic relations, Obesity -- Physiological aspects, Glucose -- Physiological aspects, Glucose metabolism -- Physiological aspects, Leptin -- Physiological aspects, Type 2 diabetes -- Physiological aspects, Medical research -- Physiological aspects, Insulin resistance -- Physiological aspects, Ceramides -- Physiological aspects, Adipose tissue -- Physiological aspects, Plant lipids -- Physiological aspects, Insulin -- Physiological aspects, Biosynthesis, Phenotypes, Endothelium
Abstract

Introduction Obesity is associated with an array of complications, including cardiovascular diseases, type 2 diabetes (T2D), fatty liver disease, osteoporosis, airway disease, degenerative disorders including dementia, and certain cancers. In [...], Adipose tissue plays important roles in regulating whole-body energy metabolism through its storage function in white adipocytes and its dissipating function in brown and beige adipocytes. Adipose tissue also produces a variety of secreted factors called adipocytokines, including leptin and adiponectin. Furthermore, recent studies have suggested the important roles of extracellular vesicles of endosomal origin termed exosomes, which are secreted from adipocytes and other cells in adipose tissue and influence whole-body glucose and lipid metabolism. Adiponectin is known to be a pleiotropic organ-protective protein that is exclusively produced by adipocytes and decreased in obesity. Adiponectin accumulates in tissues such as heart, muscle, and vascular endothelium through binding with T-cadherin, a glycosylphosphatidylinositol-anchored (GPI-anchored) cadherin. Recently, adiponectin was found to enhance exosome biogenesis and secretion, leading to a decrease in cellular ceramides, excess of which is known to cause insulin resistance and cardiovascular disease phenotypes. These findings support the hypothesis that adipose tissue metabolism systemically regulates exosome production and whole-body metabolism through exosomes. This review focuses on intra-adipose and interorgan communication by exosomes, adiponectin-stimulated exosome production, and their dysregulation in metabolic diseases.

Published
2019
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16. Coincidence of Large Adrenal Cyst and Prominent Hyporeninemic Hyperaldosteronism

Author

Takaaki Sakaue, Yosuke Okuno, Kosuke Mukai, Shingo Fujita, Junji Kozawa, Hitoshi Nishizawa, Taka-Aki Matsuoka, Hiromi Iwahashi, Maeda Norikazu, Yuto Yamazaki, Hironobu Sasano, Michio Otsuki, and Iichiro Shimomura

Subjects
Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

A 67-year-old Japanese woman who had end-stage renal disease was referred to our hospital for kidney transplantation. Abdominal CT revealed a large adrenal mass with inhomogeneity. She had a history of hospitalization for stroke and heart failure and exhibited prominent hyporeninemic hyperaldosteronism. Histological examination of the resected tumor with anti-CYP11B2 antibody indicated that she had a vascular endothelial cyst with primary aldosteronism (PA) due to multiple adrenocortical micronodules. This report implicates the pathological interaction between adrenal vascular cysts and PA-mediated vascular damage of the adrenal vein.

Published
2021
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24. Changes in Body Weight in Severely Obese Patients Treated with the Anorexiant Mazindol.

Author

Tanaka, Yoshimitsu, Maeda, Norikazu, Koseki, Masahiro, and Maeda, Kazuhisa

Subjects
*BODY weight, *OBESITY, *APPETITE depressants, *WEIGHT loss, *GLUCAGON-like peptide-1 agonists
Abstract

(1) Background: The number of severely obese patients worldwide is rapidly increasing. Recently, novel therapeutic approaches, such as bariatric surgery or GLP-1 receptor agonists, have emerged, bringing about a paradigm shift in this field. However, these therapies sometimes face challenges, such as peri-surgical complications or supply shortages. Mazindol, which is an appetite suppressant approved decades ago in Japan, remains a valuable option. In this study, we investigated the effectiveness of mazindol in reducing body weight in 147 patients, and we examined the factors influencing said effectiveness. (2) Methods: The patients were divided into four groups based on the treatment cycles they underwent: 1 cycle, 2 cycles, 3–5 cycles, and over 6 cycles. We compared the changes in body weight before and after the treatment among these four groups. Additionally, we sought to identify the factors correlated to the effectiveness of mazindol. (3) Results: The change in body weight was more pronounced in the group which underwent 3–5 cycles compared to the groups which underwent 1 cycle and 2 cycles; this change was also more pronounced in the group which underwent over 6 cycles compared to those which underwent 1 cycle. Furthermore, we observed a significant correlation between the initial body weight and the extent of body weight change. (4) Conclusions: Mazindol demonstrated effectiveness in reducing the body weight of patients in a cycle-dependent manner. [ABSTRACT FROM AUTHOR]

Published
2024
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32. The Effects of Topiroxostat, a Selective Xanthine Oxidoreductase Inhibitor, on Arterial Stiffness in Hyperuricemic Patients with Liver Dysfunction: A Sub-Analysis of the BEYOND-UA Study.

Author

Fujishima, Yuya, Nishizawa, Hitoshi, Kawachi, Yusuke, Nakamura, Takashi, Akari, Seigo, Ono, Yoshiyuki, Fukuda, Shiro, Kita, Shunbun, Maeda, Norikazu, Hoshide, Satoshi, Shimomura, Iichiro, and Kario, Kazuomi

Subjects
URIC acid, ALANINE aminotransferase, ARTERIAL diseases, PULSE wave analysis, XANTHINE, LIVER, BLOOD pressure
Abstract

Background: The effects of uric acid (UA)-lowering therapy with xanthine oxidoreductase (XOR) inhibitors on the development of cardiovascular diseases remain controversial. Based on recent findings that plasma XOR activity increased in liver disease conditions, we conducted a sub-analysis of the BEYOND-UA study to examine the differential effects of topiroxostat on arterial stiffness based on liver function in hyperuricemic individuals with hypertension. Methods: Sixty-three subjects treated with topiroxostat were grouped according to baseline alanine aminotransferase (ALT) levels (above or below cut-off values of 22, 30, or 40 U/L). The primary endpoint was changes in the cardio-ankle vascular index (CAVI) from baseline to 24 weeks. Results: Significant reductions in CAVI during topiroxostat therapy occurred in subjects with baseline ALT ≥30 U/L or ≥40 U/L, and significant between-group differences were detected. Brachial-ankle pulse wave velocity significantly decreased in the ALT-high groups at all cut-off values. Reductions in morning home blood pressure and serum UA were similar regardless of the baseline ALT level. For eleven subjects with available data, ALT-high groups showed high plasma XOR activity, which was significantly suppressed by topiroxostat. Conclusions: Topiroxostat improved arterial stiffness parameters in hyperuricemic patients with liver dysfunction, which might be related to its inhibitory effect on plasma XOR. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Changes in Eating Behaviors and Their Associations with Weight Loss in Japanese Patients Who Underwent Laparoscopic Sleeve Gastrectomy.

Author

Kimura, Yu, Fujishima, Yuya, Nishizawa, Hitoshi, Saito, Takuro, Miyazaki, Yasuhiro, Shirahase, Keiko, Tokuzawa, Chie, Nagai, Naoko, Fukuda, Shiro, Maeda, Kazuhisa, Maeda, Norikazu, Doki, Yuichiro, and Shimomura, Iichiro

Abstract

Background: Metabolic and bariatric surgery (MBS) has been established to provide long-term weight loss in severe obesity. In this study, we investigated the factors that affect post-operative weight loss, with a particular focus on changes in eating behaviors. Methods: Time-course changes in body weight and eating behaviors were examined in 49 Japanese patients who underwent laparoscopic sleeve gastrectomy from the first visit to 12 months after surgery. Each eating behavior was evaluated via the questionnaire of the Japan Society for the Study of Obesity. Results: Pre-operative weight reduction mediated by dietary and lifestyle interventions showed significant positive correlations with weight loss outcomes at 12 months after surgery. We observed significant decreases in scores for most of the eating behaviors 12 months after surgery. However, "emotional eating behavior" scores declined temporarily in the early post-operative period of one month but thereafter returned to the pre-operative level at 12 months. Furthermore, increases in the scores for "emotional eating behavior" and "sense of hunger" from 1 to 12 months post-operatively were significantly associated with poor weight loss. Conclusions: Our results demonstrate the beneficial effects of MBS on obesity-related eating behaviors, as well as highlighting "emotional eating behavior" as requiring particular attention. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Coincidence of Large Adrenal Cyst and Prominent Hyporeninemic Hyperaldosteronism

Author

Yuto Yamazaki, Junji Kozawa, Hiromi Iwahashi, Maeda Norikazu, Hitoshi Nishizawa, Michio Otsuki, Iichiro Shimomura, Kosuke Mukai, Taka-aki Matsuoka, Hironobu Sasano, Yosuke Okuno, Takaaki Sakaue, and Shingo Fujita

Subjects
Pathology, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, 030232 urology & nephrology, Case Report, 030204 cardiovascular system & hematology, medicine.disease, RC648-665, Hyperaldosteronism, Diseases of the endocrine glands. Clinical endocrinology, Adrenal Cyst, 03 medical and health sciences, 0302 clinical medicine, Primary aldosteronism, Heart failure, medicine, Cyst, business, Stroke, Pathological, Kidney transplantation
Abstract

A 67-year-old Japanese woman who had end-stage renal disease was referred to our hospital for kidney transplantation. Abdominal CT revealed a large adrenal mass with inhomogeneity. She had a history of hospitalization for stroke and heart failure and exhibited prominent hyporeninemic hyperaldosteronism. Histological examination of the resected tumor with anti-CYP11B2 antibody indicated that she had a vascular endothelial cyst with primary aldosteronism (PA) due to multiple adrenocortical micronodules. This report implicates the pathological interaction between adrenal vascular cysts and PA-mediated vascular damage of the adrenal vein.

Published
2021

40. Validation of Noninvasive Morphological and Diffusion Imaging in Mouse Emphysema by Micro-Computed Tomography and Hyperpolarized 129Xe Magnetic Resonance Imaging

Author

Tetsumoto, Satoshi, Takeda, Yoshito, Imai, Hirohiko, Kimura, Atsuomi, Jin, Yingji, Nakanishi, Kaori, Maeda, Yohei, Kuhara, Hanako, Tsujino, Kazuyuki, Iwasaki, Takeo, Shigeta, Hiroshi, Kondo, Yasushi, Ito, Mari, Minami, Toshiyuki, Hirata, Haruhiko, Takahashi, Ryo, Kohmo, Satoshi, Nagatomo, Izumi, Inoue, Koji, Kida, Hiroshi, Kijima, Takashi, Tachibana, Isao, Maeda, Norikazu, Funahashi, Toru, Shimomura, Iichiro, Fujiwara, Hideaki, and Kumanogoh, Atsushi

Published
2013
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48. Plasma NfL is associated with mild cognitive decline in patients with diabetes.

Author

Marutani, Noriko, Akamine, Shoshin, Kanayama, Daisuke, Gotoh, Shiho, Yanagida, Kanta, Maruyama, Riki, Mori, Kohji, Miyamoto, Tesshin, Adachi, Hiroyoshi, Sakagami, Yukako, Yoshiyama, Kenji, Hotta, Maki, Nagase, Aki, Kozawa, Junji, Maeda, Norikazu, Otsuki, Michio, Matsuoka, Takaaki, Iwahashi, Hiromi, Shimomura, Iichiro, and Murayama, Norihito

Subjects
COGNITION disorder risk factors, MILD cognitive impairment, NERVE tissue proteins, ACADEMIC medical centers, ONE-way analysis of variance, REGRESSION analysis, RISK assessment, PSYCHOSOCIAL factors, QUESTIONNAIRES, DESCRIPTIVE statistics, PEOPLE with diabetes
Abstract

Background: Patients with diabetes are at a higher risk for cognitive decline. Thus, biomarkers that can provide early and simple detection of cognitive decline are required. Neurofilament light chain (NfL) is a cytoskeletal protein that constitutes neural axons. Plasma NfL levels are elevated when neurodegeneration occurs. Here, we investigated whether plasma NfL levels were associated with cognitive decline in patients with type 2 diabetes. Method: This study included 183 patients with type 2 diabetes who visited Osaka University Hospital. All participants were tested for cognitive function using the Mini‐Mental State Examination (MMSE) and the Rivermead Behavioural Memory Test (RBMT). NfL levels were analysed in the plasma and the relationship between NfL and cognitive function was examined. Results: Lower RBMT‐standardized profile scores (SPS) or MMSE scores correlated with higher plasma NfL levels (one‐way analysis of variance: MMSE, P = 0.0237; RBMT‐SPS, P = 0.0001). Furthermore, plasma NfL levels (β = −0.34, P = 0.0005) and age (β = −0.19, P = 0.016) were significantly associated with the RBMT score after multivariable regression adjustment. Conclusions: Plasma NfL levels were correlated with mild cognitive decline which is detected by the RBMT but not the MMSE in patients with type 2 diabetes. This suggests that plasma NfL levels may provide a valuable clinical tool for identifying mild cognitive decline in patients with diabetes. [ABSTRACT FROM AUTHOR]

Published
2022
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