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Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) has emerged as a promising target for developing drugs to tackle renal fibrosis. In this study, a series of chromone derivatives were designed and synthesized. Additionally, we established a NOX4 overexpression model using the NRK‐49F rat renal fibroblasts cell line and identified compound 14m as highly active through the assessment of intracellular reactive oxygen species (ROS) levels in this model. The drug affinity responsive target stability (DARTS) assay illuminated the robust binding stability of 14m with NOX4. Mechanistic studies further substantiated its efficacy in ameliorating fibrosis and inflammation. This investigation positions 14m as a noteworthy NOX4 inhibitor, shedding light on its regulatory role in renal fibroblasts. Importantly, it diversifies the structural landscape of NOX4 inhibitors, offering novel lead compounds for future development. [ABSTRACT FROM AUTHOR]

Self-sovereign identity authentication protocol is an active research topic in the field of identity authentication and management. However, the current SSI authentication protocols pay little attention to privacy protection and the fine-grained access control. Therefore, a secure and decentralized SSI authentication protocol with privacy protection and fine-grained access control is proposed. Firstly, the formal model of SSI including the SDPP-SSI identity model and management model is presented. And then, based on the federated blockchain, the distributed identifier is used as a global identifier for users in the decentralized domain. Finally, the verifiable statement is encapsulated using a policy control signature supporting privacy protection to develop the user's access control for identity registration in the centralized domain. Compared with the related work (Lin 2018, Zhu 2018, Stokkink 2018, Hammudoglu 2017, Othman 2017, Abraham 2018, Guan 2019, Lin 2019) from controllability, security, flexibility, privacy protection, authentication and fine-grained access control, the proposed SSI authentication protocol not only meets controllability, authentication, and flexibility, but also supports privacy protection and fine-grained access control. [ABSTRACT FROM AUTHOR]