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216 results on '"MESH: Questionnaires"'

1. Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition

Author: Salvatore Panico, Emmanuelle Kesse, Pietro Ferrari, Bertrand Hémon, Anne Tjønneland, Eiliv Lund, Guri Skeie, Timothy J. Key, Kim Overvad, Göran Berglund, H. Bas Bueno-de-Mesquita, Carmen Navarro, Mazda Jenab, Teresa Norat, Iréne Mattisson, Nicholas E. Day, Carlos González, Dagrun Engeset, María José Sánchez, Marie-Christine Boutron-Ruault, Rudolf Kaaks, Françoise Clavel, Mathieu Mazuir, Elio Riboli, Petra H.M. Peeters, Yannis Tountas, Göran Hallmans, Manuela M. Bergmann, Anja Olsen, Sheila Bingham, Nadia Slimani, Antonia Trichopoulou, Richard Palmqvist, Dimitrios Trichopoulos, Heiner Boeing, Rosario Tumino, Jakob Linseisen, Franco Berrino, Paolo Vineis, Rodolfo Saracci, J. Ramón Quirós, Eva Ardanaz, Kay-Tee Khaw, Domenico Palli, Alexandra Nieters, Unit of Nutrition, Environment, and Cancer, Catalan Institute of Oncology, Nutrition Unit, MRC Dunn Human, Department of Clinical Epidemiology, Aarhus University Hospital, Department of Cardiology and Department of Clinical Epidemiology, Institute of Cancer Epidemiology, Danish Cancer Society, Nutrition, hormones et cancer: épidémiologie et prévention (E3N), Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DifE), Leibniz Association, Division of Clinical Epidemiology, Deutches Krebsforschungszentrum, Department of Hygiene and Epidemiology, University of Athens Medical School [Athens], Epidemiology Unit, Istituto Tumori, Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Center, Department of Clinical and Experimental Medicine, Università degli studi di Napoli Federico II, Ragusa Cancer Registry, Azienda Ospedaliera Civile MP, University of Torino and CPO-Piemonte, Università degli studi di Torino (UNITO), Center for Nutrition and Health, National Institute of Public Health and Environment, Julius Center for Health Sciences and Primary Care, VU University Medical Center [Amsterdam], Institute of Community Medicine, University of Tromsø (UiT), Public Health Institute of Navarra, Department of Epidemiology, Epidemiology Department, Health Council of Murcia, Public Health and Health Planning Directorate, Andalusian School of Public Health [Granada], Malmö Diet and Cancer Study, Lund University [Lund], Department of Nutritional Research, Umeå University, Department of Medical Biosciences, Pathology, Strangeways Research Laboratory, Clinical Gerontology Unit, University of Cambridge [UK] (CAM), Cancer Research UK Epidemiology Unit, University of Oxford [Oxford], The work described in this article was carried out with financial support of the 'Europe Against Cancer Program' of the European Commission (SANCO), the Danish Cancer Society, German Cancer Aid, Ligue Nationale contre le Cancer, the 3M Company, INSERM, the German Cancer Research Center, the GermanFederal Ministry of Education and Research, the Dutch Ministry of Public Health, Welfare and Sports, the National Cancer Registry and the Regional Cancer Registries Amsterdam, East and Maastricht of The Netherlands, the Norwegian Cancer Society, the Norwegian Research Council, the Health Research Fund (FIS) of the Spanish Ministry of Health, the Greek Ministry of Health, the Greek Ministry of Education, the Italian Association for Research on Cancer, Spanish Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, and ISCIII, Red de Centros RCESP, C03/09, the Swedish Cancer Society, the Swedish Scientific Council, the Regional Government of Skane, Sweden, Cancer Research UK, the Medical Research Council, U.K., the Stroke Association, U.K., the British Heart Foundation, the Department of Health, U.K., the Food Standards Agency, U.K., and the Wellcome Trust, U.K., University of Naples Federico II = Università degli studi di Napoli Federico II, Università degli studi di Torino = University of Turin (UNITO), University of Oxford, Clavel-Chapelon, F., Norat, T, Bingham, S, Ferrari, P, Slimani, N, Jenab, M, Mazuir, M, Overvad, K, Olsen, A, Tjonneland, A, Clavel, F, BOUTRON RUAULT, Mc, Kesse, E, Boeing, H, Bergmann, Mm, Nieters, A, Linseisen, J, Trichopoulou, A, Trichopoulos, D, Tountas, Y, Berrino, F, Palli, D, Panico, Salvatore, Tumino, R, Vineis, P, BUENO DE MESQUITA, Hb, Peeters, Ph, Engeset, D, Lund, E, Skeie, G, Ardanaz, E, Gonzalez, C, Navarro, C, Quiros, Jr, Sanchez, Mj, Berglund, G, Mattisson, I, Hallmans, G, Palmqvist, R, Day, Ne, Khaw, Kt, Key, Tj, SAN JOAQUIN, M, Hemon, B, Saracci, R, Kaaks, R, and Riboli, E.
Subjects: Dietary Fiber, Male, Cancer Research, 030309 nutrition & dietetics, Colorectal cancer, MESH: Food Habits, Gastroenterology, Poultry, MESH: Proportional Hazards Models, 0302 clinical medicine, Risk Factors, MESH: Poultry, Surveys and Questionnaires, Odds Ratio, MESH: Animals, Prospective Studies, Prospective cohort study, 2. Zero hunger, MESH: Aged, MESH: Meat, 0303 health sciences, MESH: Middle Aged, MESH: Risk, Fishes, Absolute risk reduction, MESH: Life Style, Confounding Factors, Epidemiologic, Middle Aged, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Europe, Oncology, Research Design, 030220 oncology & carcinogenesis, Income, Red meat, Educational Status, Population study, Female, Colorectal Neoplasms, Adult, medicine.medical_specialty, Meat, [SDV.CAN]Life Sciences [q-bio]/Cancer, Risk Assessment, Article, MESH: Multivariate Analysis, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Internal medicine, medicine, Animals, Humans, ddc:610, European Union, Risk factor, Life Style, Aged, Proportional Hazards Models, MESH: Humans, business.industry, MESH: Questionnaires, Cancer, MESH: Adult, Feeding Behavior, medicine.disease, MESH: Male, MESH: Odds Ratio, MESH: Prospective Studies, Surgery, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, MESH: Fishes, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Multivariate Analysis, MESH: Dietary Fiber, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe, business, MESH: Female, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, MESH: Colorectal Neoplasms
Abstract: Background: Current evidence suggests that high red meat intake is associated with increased colorectal cancer risk. High fish intake may be associated with a decreased risk, but the existing evidence is less convincing. Methods: We prospectively followed 478 040 men and women from 10 European countries who were free of cancer at enrollment between 1992 and 1998. Information on diet and lifestyle was collected at baseline. After a mean follow-up of 4.8 years, 1329 incident colorectal cancers were documented. We examined the relationship between intakes of red and processed meat, poultry, and fish and colorectal cancer risk using a proportional hazards model adjusted for age, sex, energy (nonfat and fat sources), height, weight, work-related physical activity, smoking status, dietary fiber and folate, and alcohol consumption, stratified by center. A calibration substudy based on 36 994 subjects was used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. All statistical tests were two-sided. Results: Colorectal cancer risk was positively associated with intake of red and processed meat (highest [>160 g/day] versus lowest [80 g/day versus
Published: 2016

2. A monocentric experience of growth hormone replacement therapy in adult patients

Author: Lyès Abdi, Frederic Castinetti, Thierry Brue, Frédérique Albarel, Roch Giorgi, Isabelle Morange, M Sahnoun-Fathallah, Service d'endocrinologie, diabète et maladies métaboliques, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Dumonceaud, Corinne, and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, Endocrinology, Diabetes and Metabolism, Growth hormone, 0302 clinical medicine, Endocrinology, Quality of life, Bone Density, Surveys and Questionnaires, MESH: Human Growth Hormone, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], MESH: Bone Density, Bone mineral, MESH: Aged, MESH: Middle Aged, Human Growth Hormone, MESH: Hormone Replacement Therapy, General Medicine, Middle Aged, MESH: Patient Compliance, 3. Good health, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Body Composition, Female, France, Adult, medicine.medical_specialty, Waist, Hormone Replacement Therapy, 030209 endocrinology & metabolism, Growth hormone deficiency, 03 medical and health sciences, Internal medicine, medicine, Humans, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Aged, Retrospective Studies, Femoral neck, MESH: Humans, Adult patients, business.industry, MESH: Questionnaires, MESH: Quality of Life, Retrospective cohort study, MESH: Adult, MESH: Retrospective Studies, MESH: Body Composition, medicine.disease, MESH: Male, Surgery, MESH: France, Quality of Life, Patient Compliance, business, MESH: Female
Abstract: International audience; To describe the results of growth hormone (GH) therapy in adult GH-deficient patients treated in a tertiary referral center, with a focus on quality of life and adherence. Retrospective study of patients followed over a total period of 11 years. Quality of life (QOL) was assessed by the QOL-Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA) score and adherence to treatment was measured by a specific questionnaire. Clinical, biological, body composition and bone mineralization parameters were also analyzed. Data from 81 patients were analyzed. After a median treatment duration of 7 years, 2/3 of patients reported improved QOL (mean decrease of AGHDA score of 3.0 points, P
Published: 2014

3. MCID determination using IRT models

Author: Rouquette, Alexandra, Blanchin, Myriam, Sébille, Véronique, Guillemin, Francis, Côté, Sylvana, Falissard, Bruno, Hardouin, Jean-Benoit, Troubles du comportement alimentaire de l'adolescent (UMR_S 669), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11), Research Unit on Children's Psychosocial Maladjustment, University of Montreal, Service Universitaire de Santé Publique, Université d'Angers (UA), Biostatistique, Recherche Clinique et Mesures Subjectives en Santé, Université de Nantes (UN), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Nancy, Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of preventive and social medicine, Service de Santé Publique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse, The SATISQOL cohort project was supported by an IRESP (Institut de inserm-00936664, version 1 - 27 Jan 2014 17 recherche en santé publique) grant from Inserm, and a PHRC (Programme Hospitalier de Recherche Clinique) national grant from French Ministry of Health, France, Troubles du comportement alimentaire de l'adolescent ( UMR_S 669 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris-Sud - Paris 11 ( UP11 ), Université d'Angers ( UA ), Université de Nantes ( UN ), Maladies chroniques, santé perçue, et processus d'adaptation ( APEMAC ), Université Paris Descartes - Paris 5 ( UPD5 ) -Université de Lorraine ( UL ), Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale ( INSERM ), and Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse
Subjects: Questionnaires, MESH: Aged, MESH: Humans, MESH : Outcome Assessment (Health Care), MESH: Self Report, MESH : Models, Theoretical, Minimal clinically important difference, MESH: Questionnaires, MESH : Humans, MESH : Aged, Patient‐reported outcomes, MESH : Questionnaires, MESH : Self Report, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Rasch models, Item response theory, humanities, Sensitivity and specificity, MESH: Severity of Illness Index, MESH : Severity of Illness Index, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Models, Theoretical, MESH: Outcome Assessment (Health Care)
Abstract: International audience; OBJECTIVES: Determining the minimal clinically important difference (MCID) of questionnaires on an interval scale, the trait level (TL) scale, using item response theory (IRT) models could overcome its association with baseline severity. The aim of this study was to compare the sensitivity (Se), specificity (Sp), and predictive values (PVs) of the MCID determined on the score scale (MCID-Sc) or the TL scale (MCID-TL). STUDY DESIGN AND SETTING: The MCID-Sc and MCID-TL of the MOS-SF36 general health subscale were determined for deterioration and improvement on a cohort of 1,170 patients using an anchor-based method and a partial credit model. The Se, Sp, and PV were calculated using the global rating of change (the anchor) as the gold standard test. RESULTS: The MCID-Sc magnitude was smaller for improvement (1.58 points) than for deterioration (-7.91 points). The Se, Sp, and PV were similar for MCID-Sc and MCID-TL in both cases. However, if the MCID was defined on the score scale as a function of a range of baseline scores, its Se, Sp, and PV were consistently higher. CONCLUSION: This study reinforces the recommendations concerning the use of an MCID-Sc defined as a function of a range of baseline scores.
Published: 2014

4. MCID determination using IRT models

Author: Rouquette, Alexandra, Blanchin, Myriam, Sébille, Véronique, Guillemin, Francis, Côté, Sylvana, Falissard, Bruno, Hardouin, Jean-Benoit, Rouquette, Alexandra, Troubles du comportement alimentaire de l'adolescent (UMR_S 669), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11), Research Unit on Children's Psychosocial Maladjustment, University of Montreal, Service Universitaire de Santé Publique, Université d'Angers (UA), Biostatistique, Recherche Clinique et Mesures Subjectives en Santé, Université de Nantes (UN), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Nancy, Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of preventive and social medicine, Service de Santé Publique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse, and The SATISQOL cohort project was supported by an IRESP (Institut de inserm-00936664, version 1 - 27 Jan 2014 17 recherche en santé publique) grant from Inserm, and a PHRC (Programme Hospitalier de Recherche Clinique) national grant from French Ministry of Health, France
Subjects: Questionnaires, MESH: Aged, MESH: Humans, MESH: Self Report, Minimal clinically important difference, MESH: Questionnaires, Patient‐reported outcomes, Rasch models, Item response theory, humanities, Sensitivity and specificity, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Severity of Illness Index, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Models, Theoretical, MESH: Outcome Assessment (Health Care)
Abstract: International audience; OBJECTIVES: Determining the minimal clinically important difference (MCID) of questionnaires on an interval scale, the trait level (TL) scale, using item response theory (IRT) models could overcome its association with baseline severity. The aim of this study was to compare the sensitivity (Se), specificity (Sp), and predictive values (PVs) of the MCID determined on the score scale (MCID-Sc) or the TL scale (MCID-TL). STUDY DESIGN AND SETTING: The MCID-Sc and MCID-TL of the MOS-SF36 general health subscale were determined for deterioration and improvement on a cohort of 1,170 patients using an anchor-based method and a partial credit model. The Se, Sp, and PV were calculated using the global rating of change (the anchor) as the gold standard test. RESULTS: The MCID-Sc magnitude was smaller for improvement (1.58 points) than for deterioration (-7.91 points). The Se, Sp, and PV were similar for MCID-Sc and MCID-TL in both cases. However, if the MCID was defined on the score scale as a function of a range of baseline scores, its Se, Sp, and PV were consistently higher. CONCLUSION: This study reinforces the recommendations concerning the use of an MCID-Sc defined as a function of a range of baseline scores.
Published: 2014

5. [Brachytherapy training: a survey of French radiation oncology residents]

Author: Fumagalli, I, Faivre, J-C, Thureau, S, Bibault, J-E, Diaz, O, Leroy, T, Pichon, B, Riou, O, Fournier, C, Hannoun-Lévi, J-M, Peiffert, D, Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Ciblage thérapeutique en Oncologie (EA3738), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, IFP Energies nouvelles (IFPEN), Radiothérapie Oncologique, Université de Montpellier (UM), Institut National de Prévention et d'Education pour la Santé (INPES), Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA), and Centre Alexis Vautrin (CAV)
Subjects: Male, Genital Neoplasms, Female, Teaching Materials, [SDV]Life Sciences [q-bio], Brachytherapy, MESH: Cross-Sectional Studies, MESH: Genital Neoplasms, Female, MESH: Internship and Residency, Surveys and Questionnaires, Humans, MESH: Data Collection, MESH: Radiotherapy Dosage, MESH: Radiotherapy Planning, Computer-Assisted, MESH: Humans, MESH: Curriculum, Data Collection, Radiotherapy Planning, Computer-Assisted, MESH: Questionnaires, Internship and Residency, Prostatic Neoplasms, MESH: Teaching Materials, Radiotherapy Dosage, MESH: Radiation Oncology, MESH: Male, MESH: France, Cross-Sectional Studies, MESH: Prostatic Neoplasms, Radiation Oncology, Female, Curriculum, France, MESH: Brachytherapy, MESH: Female
Abstract: International audience; The goal of this study was to evaluate the interest of the members of the French society of young radiation oncologists (SFjRO) for brachytherapy as well as their theoretical and practical level in this radiation technique. An anonymous survey was conducted regarding practical and theoretical teaching of brachytherapy before the French national courses on brachytherapy. Among the 106 residents attending this teaching course, 99 (93%) answered the survey. Most of them were interested in brachytherapy but 82% considered they had not received sufficient teaching. Relevant indications of brachytherapy were known by 76% of the residents for gynaecological malignancies and 70% for prostate. Seventy-one percent of the residents have seen at least one gynecological brachytherapy but only 12% knew how to deal with this technique. Fifty-six percent have seen vaginal high dose rate brachytherapy and 21% had acquired the technique. For prostate brachytherapy, 65% had seen and done an implant and only 4% had acquired the technique. Fifty percent have performed at least one brachytherapy treatment during their residency. Residents expressed a strong wish for more courses about dosimetry (82%), technique (75%) and treatment planning (90%). Our study shows the interest of French residents for brachytherapy but suggests that practical teaching courses and an evaluation of the existing theoretical courses are warranted.
Published: 2014

6. Migraine headaches and pain with neuropathic characteristics: comorbid conditions in patients with multiple sclerosis

Author: Moisset, Xavier, Ouchchane, Lemlih, Guy, Nathalie, Bayle, Dimitri, Dallel, Radhouane, Clavelou, Pierre, Neuro-Dol (Neuro-Dol), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Biostatistiques [CHU Clermont-Ferrand], Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Image Science for Interventional Techniques (ISIT), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Centre National de la Recherche Scientifique (CNRS), Service d‟Odontologie, CHU Clermont-Ferrand-Université d'Auvergne - Clermont-Ferrand I (UdA)-CHU Estaing [Clermont-Ferrand], and CHU Clermont-Ferrand
Subjects: Multiple Sclerosis, MESH: Humans, MESH: Middle Aged, MESH: Questionnaires, MESH: Neuralgia, Headache, Pain, MESH: Adult, MESH: Comorbidity, MESH: Multiple Sclerosis, MESH: Migraine Disorders, Neuropathic pain, MESH: Male, MESH: France, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH: Cohort Studies, MESH: Female, Migraine
Abstract: International audience; We conducted a postal survey to assess the prevalence and characteristics of neuropathic pain and migraine in a cohort of multiple sclerosis (MS) patients. Of the 1300 questionnaires sent, 673 could be used for statistical analysis. Among the respondents, the overall pain prevalence in the previous month was 79%, with 51% experiencing pain with neuropathic characteristics (NCs) and 46% migraine. MS patients with both migraine and NC pain (32% of the respondents) reported more severe pain and had lower health-related quality of life than MS patients with either migraine or NC pain. Pain intensity in MS patients with migraine was moderate (6.0 ± 0.1). Migraine was mostly episodic, but headaches were occurring on ≥15 days per month in 15% of those with migraine. MS patients with migraine were younger and had shorter disease durations than those with NC pain. NC pain was most often located in the extremities, back and head, and was frequently described as tingling and pins-and-needles. The intensity of NC pain was low to moderate (4.9 ± 0.1), but positively correlated with the number of painful body sites. Nonetheless, patients with NC pain were more disabled (with a higher Expanded Disability Status Scale and pain interference index) than patients with migraine. Migraine, but not NC pain, was associated with age, disease duration, relapsing-remitting course, and interferon-beta treatment. This suggests that NC pain and migraine are mediated by different mechanisms. Therefore, pain mechanisms that specifically operate in MS patients need to be characterized to design optimal treatments for these individuals.
Published: 2013

7. Migraine headaches and pain with neuropathic characteristics: comorbid conditions in patients with multiple sclerosis

Author: Moisset, Xavier, Ouchchane, Lemlih, Guy, Nathalie, Bayle, Dimitri, Dallel, Radhouane, Clavelou, Pierre, Neuro-Dol (Neuro-Dol), Université d'Auvergne - Clermont-Ferrand I (UdA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Biostatistiques [CHU Clermont-Ferrand], Direction de la recherche clinique et de l’innovation [CHU Clermont-Ferrand] (DRCI), CHU Clermont-Ferrand-CHU Clermont-Ferrand, Image Science for Interventional Techniques (ISIT), Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université-Centre National de la Recherche Scientifique (CNRS), Service d‟Odontologie, CHU Clermont-Ferrand-Université d'Auvergne - Clermont-Ferrand I (UdA)-CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, and Moisset, Xavier
Subjects: Multiple Sclerosis, MESH: Humans, MESH: Middle Aged, MESH: Questionnaires, MESH: Neuralgia, Headache, Pain, MESH: Adult, MESH: Comorbidity, MESH: Multiple Sclerosis, MESH: Migraine Disorders, Neuropathic pain, MESH: Male, MESH: France, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH: Cohort Studies, MESH: Female, Migraine
Abstract: International audience; We conducted a postal survey to assess the prevalence and characteristics of neuropathic pain and migraine in a cohort of multiple sclerosis (MS) patients. Of the 1300 questionnaires sent, 673 could be used for statistical analysis. Among the respondents, the overall pain prevalence in the previous month was 79%, with 51% experiencing pain with neuropathic characteristics (NCs) and 46% migraine. MS patients with both migraine and NC pain (32% of the respondents) reported more severe pain and had lower health-related quality of life than MS patients with either migraine or NC pain. Pain intensity in MS patients with migraine was moderate (6.0 ± 0.1). Migraine was mostly episodic, but headaches were occurring on ≥15 days per month in 15% of those with migraine. MS patients with migraine were younger and had shorter disease durations than those with NC pain. NC pain was most often located in the extremities, back and head, and was frequently described as tingling and pins-and-needles. The intensity of NC pain was low to moderate (4.9 ± 0.1), but positively correlated with the number of painful body sites. Nonetheless, patients with NC pain were more disabled (with a higher Expanded Disability Status Scale and pain interference index) than patients with migraine. Migraine, but not NC pain, was associated with age, disease duration, relapsing-remitting course, and interferon-beta treatment. This suggests that NC pain and migraine are mediated by different mechanisms. Therefore, pain mechanisms that specifically operate in MS patients need to be characterized to design optimal treatments for these individuals.
Published: 2013

8. The dietary n6:n3 fatty acid ratio during pregnancy is inversely associated with child neurodevelopment in the EDEN mother-child cohort

Author: Bernard, Jonathan, de Agostini, Maria, Forhan, Anne, de Lauzon-Guillain, Blandine, Charles, Marie-Aline, Heude, Barbara, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Support for the EDEN study (Étude des Déterminantspré- et postnatalsprécoces du développement et de la santé de l'ENfant): Fondation pour la RechercheMédicale (FRM), French Ministry of Research IFR and Cohort Program, INSERM Nutrition Research Program, French Ministry of Health Perinatality Program, French Agency for Environment Security (AFFSET), French National Institute for Population Health Surveillance (INVS), Paris-Sud University, French National Institute for Health Education (INPES), Nestlé, MutuelleGénérale de l'ÉducationNationale (MGEN), French Speaking Association for the Study of Diabetes and Metabolism (Alfediam), National Agency for Research (ANR nonthematic program), and National Institute for Research in Public Health (IRESP TGIR Cohorte Santé 2008 Program)., the EDEN Mother-Child Cohort Study Group, and De Lauzon-Guillain, Blandine
Subjects: MESH: Meat, MESH: Child Development, MESH: Humans, MESH: Milk, Human, MESH: Questionnaires, MESH: Child, Preschool, MESH: Adult, MESH: Nutrition Assessment, MESH: Male, MESH: Prospective Studies, MESH: Maternal Nutritional Physiological Phenomena, MESH: Brain, MESH: Fishes, MESH: Pregnancy, MESH: Diet, MESH: Fatty Acids, Omega-3, MESH: Young Adult, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Breast Feeding, MESH: Fatty Acids, Omega-6, MESH: Animals, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Female
Abstract: International audience; Long-chain polyunsaturated fatty acids (LC-PUFAs) of the n6 (ω6) and n3 series are essential for the development of a child's brain. Fetal LC-PUFA exposure as well as infant exposure via breast milk depend on the maternal intake of these LC-PUFAs and of their respective dietary precursors (PUFAs). We aimed to investigate the associations between maternal LC-PUFA and PUFA [(LC)PUFA] dietary intake during pregnancy and child neurodevelopment at ages 2 and 3 y. In 1335 mother-child pairs from the EDEN cohort, we evaluated associations between daily maternal (LC)PUFA intake during the last 3 months of pregnancy with the child's language at age 2 y and with different assessments of development at age 3 y. Associations were investigated separately in breastfed and never-breastfed children. We examined interactions between the ratios of n6 and n3 (LC)PUFA intakes (n6:n3 fatty acid ratio) and duration of breastfeeding. Breastfeeding mothers had a lower n6:n3 fatty acid ratio (8.4 vs. 8.8; P = 0.02). Among never-breastfed children (n = 338), we found negative associations between maternal dietary n6:n3 fatty acid ratios and neurodevelopment, as reflected by the child's language at age 2 y (β ± SE = -2.1 ± 0.7; P = 0.001) and development assessed with the Ages and Stages Questionnaire at age 3 y (-1.5 ± 0.8; P = 0.05). Among mothers with a high n6:n3 fatty acid ratio only, breastfeeding duration was positively associated with language at age 2 y (P-interaction < 0.05). This suggests that the ratio between maternal dietary n6 and n3 (LC)PUFA intake possibly influences the child's brain development during fetal life but not during or by breastfeeding. However, breastfeeding might compensate for prenatal imbalance in maternal dietary n6:n3 fatty acid ratio.
Published: 2013

9. The dietary n6:n3 fatty acid ratio during pregnancy is inversely associated with child neurodevelopment in the EDEN mother-child cohort.: Dietary PUFA in pregnancy and infant development

Author: Blandine de Lauzon-Guillain, Maria De Agostini, Anne Forhan, Marie-Aline Charles, Barbara Heude, Jonathan Y. Bernard, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Support for the EDEN study (Étude des Déterminantspré- et postnatalsprécoces du développement et de la santé de l'ENfant): Fondation pour la RechercheMédicale (FRM), French Ministry of Research IFR and Cohort Program, INSERM Nutrition Research Program, French Ministry of Health Perinatality Program, French Agency for Environment Security (AFFSET), French National Institute for Population Health Surveillance (INVS), Paris-Sud University, French National Institute for Health Education (INPES), Nestlé, MutuelleGénérale de l'ÉducationNationale (MGEN), French Speaking Association for the Study of Diabetes and Metabolism (Alfediam), National Agency for Research (ANR nonthematic program), and National Institute for Research in Public Health (IRESP TGIR Cohorte Santé 2008 Program)., and the EDEN Mother-Child Cohort Study Group
Subjects: Male, Pediatrics, 030309 nutrition & dietetics, Maternal Nutritional Physiological Phenomena, Breastfeeding, Medicine (miscellaneous), Physiology, 0302 clinical medicine, Child Development, MESH: Pregnancy, MESH: Fatty Acids, Omega-3, Pregnancy, Surveys and Questionnaires, MESH: Fatty Acids, Omega-6, MESH: Animals, 030212 general & internal medicine, Prospective Studies, 2. Zero hunger, chemistry.chemical_classification, MESH: Meat, 0303 health sciences, Nutrition and Dietetics, MESH: Milk, Human, Fishes, Brain, MESH: Nutrition Assessment, MESH: Maternal Nutritional Physiological Phenomena, Breast Feeding, MESH: Young Adult, Child, Preschool, MESH: Breast Feeding, Female, Polyunsaturated fatty acid, Adult, medicine.medical_specialty, Meat, Biology, Breast milk, 03 medical and health sciences, Young Adult, MESH: Brain, MESH: Diet, Fatty Acids, Omega-6, Fatty Acids, Omega-3, medicine, Animals, Humans, MESH: Child Development, MESH: Humans, Milk, Human, MESH: Questionnaires, MESH: Child, Preschool, Fatty acid, Infant exposure, MESH: Adult, medicine.disease, MESH: Male, MESH: Prospective Studies, Diet, Nutrition Assessment, MESH: Fishes, chemistry, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Breast feeding, MESH: Female
Abstract: International audience; Long-chain polyunsaturated fatty acids (LC-PUFAs) of the n6 (ω6) and n3 series are essential for the development of a child's brain. Fetal LC-PUFA exposure as well as infant exposure via breast milk depend on the maternal intake of these LC-PUFAs and of their respective dietary precursors (PUFAs). We aimed to investigate the associations between maternal LC-PUFA and PUFA [(LC)PUFA] dietary intake during pregnancy and child neurodevelopment at ages 2 and 3 y. In 1335 mother-child pairs from the EDEN cohort, we evaluated associations between daily maternal (LC)PUFA intake during the last 3 months of pregnancy with the child's language at age 2 y and with different assessments of development at age 3 y. Associations were investigated separately in breastfed and never-breastfed children. We examined interactions between the ratios of n6 and n3 (LC)PUFA intakes (n6:n3 fatty acid ratio) and duration of breastfeeding. Breastfeeding mothers had a lower n6:n3 fatty acid ratio (8.4 vs. 8.8; P = 0.02). Among never-breastfed children (n = 338), we found negative associations between maternal dietary n6:n3 fatty acid ratios and neurodevelopment, as reflected by the child's language at age 2 y (β ± SE = -2.1 ± 0.7; P = 0.001) and development assessed with the Ages and Stages Questionnaire at age 3 y (-1.5 ± 0.8; P = 0.05). Among mothers with a high n6:n3 fatty acid ratio only, breastfeeding duration was positively associated with language at age 2 y (P-interaction < 0.05). This suggests that the ratio between maternal dietary n6 and n3 (LC)PUFA intake possibly influences the child's brain development during fetal life but not during or by breastfeeding. However, breastfeeding might compensate for prenatal imbalance in maternal dietary n6:n3 fatty acid ratio.
Published: 2013

10. Repeated exposure of infants at complementary feeding to a vegetable puree increases acceptance as effectively as flavor-flavor learning and more effectively than flavor-nutrient learning

Author: Eloïse, Remy, Sylvie, Issanchou, Claire, Chabanet, Sophie, Nicklaus, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA ), and Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS )
Subjects: Male, MESH: Infant Nutritional Physiological Phenomena, MESH : Infant Nutritional Physiological Phenomena, [ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition, MESH : Vegetables, MESH : Taste, MESH : Learning, Cynara scolymus, Surveys and Questionnaires, flavor-nutrient learning, MESH : Female, Infant Nutritional Physiological Phenomena, MESH : Food Preferences, learning, infants, weaning, MESH : Questionnaires, MESH : Infant, MESH : Feeding Behavior, MESH: Follow-Up Studies, MESH: Infant, Daucus carota, repeated exposure, MESH: Cynara scolymus, Taste, MESH: Feeding Behavior, Female, Infant Food, vegetables, MESH : Daucus carota, MESH : Male, MESH : Cynara scolymus, complementary feeding, Food Preferences, MESH: Daucus carota, Humans, MESH: Food Preferences, MESH: Infant Food, conditioned satiation, MESH: Humans, MESH: Questionnaires, MESH : Humans, Infant, MESH : Follow-Up Studies, Feeding Behavior, MESH : Infant Food, flavor-flavor learning, MESH: Vegetables, MESH: Male, MESH: Learning, MESH: Taste, MESH: Female, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Follow-Up Studies
Abstract: Clé UT : 000320894800025 ; Supported by the European Community's Seventh Framework Program (FP7/2007-2013) under the grant agreement no. FP7-245012-HabEat.; International audience; Children's vegetable consumption is below the public health recommendations. This study aimed to compare learning mechanisms to increase vegetable acceptance in infants at complementary feeding, namely repeated exposure (RE), flavor-flavor learning (FFL), and flavor-nutrient learning (FNL); measure the stability of the learning effect; and examine the impact of infants' feeding history on vegetable acceptance. The study was composed of a preexposure test, an exposure period, a postexposure test, and tests at 2-wk, 3-mo, and 6-mo follow-ups. At pre- and postexposure, a basic artichoke purée and carrot purée were presented to 95 French infants (6.4 ± 0.8 mo). During the exposure period, infants were randomly split into 3 groups and were exposed 10 times to the basic (RE group; 2 kJ/g; n = 32), a sweet (FFL group; 2 kJ/g; n = 32), or an energy-dense (FNL group; 6 kJ/g; n = 31) artichoke purée 2 or 3 times/wk. To evaluate acceptance, intake (g) and liking were recorded at home by parents. Between pre- and postexposure, intake of the basic artichoke purée significantly increased in the RE (+63%) and FFL (+39%) groups but not in the FNL group; liking increased only in the RE group (+21%). After exposure, artichoke was as much consumed and as much liked as carrot only in the RE group. Learning of artichoke acceptance was stable up to 3 mo postexposure. Initial artichoke intake was significantly related to the number of vegetables offered before the study started. RE is as effective as and simpler to implement than FFL and more effective than FNL for increasing vegetable acceptance at complementary feeding.
Published: 2013

11. Inflammatory response and IgE sensitization at early age

Author: Josef Riedler, Outi Vaarala, Roger Lauener, Erika von Mutius, Juha Pekkanen, K. Mustonen, Leea Keski-Nisula, Juliane Weber, Petra Ina Pfefferle, Anne Hyvärinen, Caroline Roduit, Bianca Schaub, Jon Genuneit, Charlotte Braun-Fahrländer, Jean-Charles Dalphin, L. Orivuori, Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Institute of Epidemiology, Universität Ulm, Asthma and Allergy Department, University Children's Hospital-Ludwig Maximilians University, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), and Universität Ulm - Ulm University [Ulm, Allemagne]
Subjects: MESH: Inflammation, Hypersensitivity, Immediate, Rural Population, Allergy, Urban Population, MESH : Risk, MESH : Child, Preschool, Immunoglobulin E, MESH : Hypersensitivity, Immediate, Allergic sensitization, 0302 clinical medicine, MESH: Rural Population, Surveys and Questionnaires, Immunology and Allergy, 2. Zero hunger, 0303 health sciences, MESH: Risk, MESH : Prognosis, biology, MESH: Immunoglobulin E, MESH : Questionnaires, MESH : Infant, Atopic dermatitis, MESH: Follow-Up Studies, Prognosis, MESH: Infant, 3. Good health, Europe, MESH: Urban Population, C-Reactive Protein, Child, Preschool, MESH : Urban Population, Hay fever, MESH: Hypersensitivity, Immediate, Risk, Immunology, MESH: Environmental Exposure, MESH : Europe, MESH : Immunoglobulin E, MESH: Prognosis, [ SDV.EE.SANT ] Life Sciences [q-bio]/Ecology, environment/Health, 03 medical and health sciences, Hygiene hypothesis, MESH: C-Reactive Protein, medicine, Humans, 030304 developmental biology, Asthma, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Inflammation, MESH: Humans, MESH : Inflammation, business.industry, MESH: Questionnaires, C-reactive protein, MESH: Child, Preschool, MESH : Humans, Infant, MESH : Follow-Up Studies, Environmental Exposure, MESH : C-Reactive Protein, medicine.disease, MESH : Rural Population, 030228 respiratory system, Pediatrics, Perinatology and Child Health, biology.protein, MESH: Europe, business, MESH : Environmental Exposure, Follow-Up Studies
Abstract: International audience; BACKGROUND: Microbial exposure may induce low-grade inflammation at an early age and decrease the risk of allergic diseases, as suggested by the hygiene hypothesis. We examined the associations between low-grade inflammation and the development of allergic sensitization, atopic dermatitis (AD), and asthma at the age of 4.5 yr. METHODS: We studied 636 children participating in the PASTURE study in Finland, Germany, Austria, France, and Switzerland. Data of environmental factors, doctor-diagnosed AD, and asthma were collected by questionnaire. The serum high-sensitivity C-reactive protein (CRP) values were measured at the age of 1 yr, and serum-specific IgE concentrations (sIgE) at the age of one and 4.5 yr. Analyses were made by logistic regression analysis. RESULTS: The risk of allergic sensitization at the age of 4.5 yr was decreased in children who had increased CRP levels at the age of 1 yr (level in the highest vs. lowest quartile: aOR 0.48, 95% CI 0.24-0.95; p = 0.014). The risk of AD and asthma was not significantly related to CRP. CONCLUSION: The findings confirm that elevated levels of CRP at early age showed association with decreased allergic sensitization later in life. Our results suggest that poor inflammatory response could predispose for IgE sensitization.
Published: 2013

12. Effect of clinical spectrum, inoculum size and physician characteristics on sensitivity of a rapid antigen detection test for group A streptococcal pharyngitis

Author: Philippe Bidet, Edouard Bingen, Martin Chalumeau, M. Koskas, Robert M. Cohen, M. Benani, Jérémie F. Cohen, Corinne Levy, Service de pédiatrie générale [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Recherche Epidémiologique en Santé Périnatale et Santé des Femmes et des Enfants (UMR_S 953), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Association Clinique et Thérapeutique du Val-de-Marne (ACTIV), ACTIV, Centre de Recherche Clinique [Créteil] (CRC), Centre Hospitalier Intercommunal de Créteil (CHIC), AP-HP Hôpital universitaire Robert-Debré [Paris], Service de microbiologie, CHI Créteil, This study was internally funded by ACTIV and externally by Dectrapharm, manufacturer of the RADT (Rapid Antigen Detection Test). JFC was supported by educational grants from Agence Régionale de Santé d'Ile-de-France, Laboratoires Guigoz - Société Française de Pédiatrie - Groupe de Pédiatrie Générale - Groupe de Recherches Epidémiologiques en Pédiatrie, and a research grant from the French Ministry of Health (PHRC Régional 2012, AOR 12089)., Debs, Nayla, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Recherche Epidémiologique en Santé Périnatale et Santé des Femmes et des Enfants ( UMR_S 953 ), Université Paris-Sud - Paris 11 ( UP11 ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de Recherche Clinique (CRC), and Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 ( UPD7 )
Subjects: Male, Pediatrics, MESH : Streptococcal Infections, MESH : Child, Preschool, medicine.disease_cause, Group A, 0302 clinical medicine, Medical microbiology, MESH : Child, MESH: Streptococcal Infections, Surveys and Questionnaires, MESH: Child, MESH: Physicians, MESH : Female, 030212 general & internal medicine, Child, MESH: Middle Aged, medicine.diagnostic_test, Streptococcus, MESH : Antigens, Bacterial, MESH : Questionnaires, Pharyngitis, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, General Medicine, Middle Aged, 3. Good health, Infectious Diseases, medicine.anatomical_structure, Child, Preschool, MESH : Streptococcus pyogenes, MESH: Immunologic Tests, Female, Clinical Competence, MESH: Clinical Competence, MESH : Sensitivity and Specificity, medicine.symptom, MESH: Streptococcus pyogenes, Microbiology (medical), medicine.medical_specialty, Adolescent, Streptococcus pyogenes, MESH : Male, MESH : Physicians, Immunologic Tests, Sensitivity and Specificity, Asymptomatic, Throat culture, 03 medical and health sciences, Physicians, Streptococcal Infections, MESH : Adolescent, 030225 pediatrics, Throat, medicine, Humans, MESH : Middle Aged, MESH: Adolescent, Antigens, Bacterial, MESH: Humans, business.industry, MESH: Pharyngitis, MESH: Questionnaires, MESH : Pharyngitis, MESH : Humans, MESH: Child, Preschool, MESH : Clinical Competence, Confidence interval, MESH: Sensitivity and Specificity, MESH: Male, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH : Immunologic Tests, MESH: Female, MESH: Antigens, Bacterial
Abstract: International audience; We aimed to assess the independent effect of clinical spectrum, bacterial inoculum size and physician characteristics on the sensitivity of a rapid antigen detection test (RADT) for group A streptococcus (GAS) in children. Double throat swabs were collected from 1,482 children with pharyngitis and 294 asymptomatic children in a French prospective, office-based, multicenter (n = 17) study, from October 2009 to May 2011. Patient- and physician-level factors potentially affecting RADT sensitivity were studied by univariate and multivariate multilevel analysis, with laboratory throat culture as the reference test. In children with pharyngitis and asymptomatic children, the prevalence of GAS was 38 % (95 % confidence interval 36-41 %) and 11 % (7-14 %), respectively. Overall, RADT sensitivity was 87 % (84-90 %). On stratified and multivariate multilevel analysis, RADT sensitivity was higher for children with pharyngitis than asymptomatic children (89 % vs. 41 %), children 99 %). The sensitivity of the RADT is independently affected by patient- and physician-level factors. Physicians who base their diagnosis of GAS pharyngitis on the results of a RADT alone should consider diagnostic accuracy monitoring and adequate training when needed.
Published: 2013

13. Can remission in rheumatoid arthritis be assessed without laboratory tests or a formal joint count? possible remission criteria based on a self-report RAPID3 score and careful joint examination in the ESPOIR cohort

Author: Bernard Combe, Bruno Fautrel, Isabel Castrejón, Maxime Dougados, Francis Guillemin, Theodore Pincus, Division of Rheumatology (NYU Hospital - Rheumato), New York University Langone Medical Center (NYU Langone Medical Center), NYU System (NYU)-NYU System (NYU), Service de rhumatologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université Paris Descartes - Paris 5 (UPD5)-Université de Lorraine (UL), Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Nancy, Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale (INSERM), Rhumatologie, Université Paris Diderot - Paris 7 (UPD7), CHU Cochin [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Université de Montpellier (UM)-Université Montpellier 1 (UM1), Division of Rheumatology ( NYU Hospital - Rheumato ), New York University Hospital, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Cochin [AP-HP], Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - IURC, Université Montpellier 1 ( UM1 ) -Université de Montpellier ( UM ), Institut de Génétique Moléculaire de Montpellier ( IGMM ), Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ), Maladies chroniques, santé perçue, et processus d'adaptation. Approches épidémiologiques et psychologiques. ( APEMAC - EA 4360 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Université de Lorraine ( UL ), Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris Diderot - Paris 7 ( UPD7 ), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 ( AIDMP ), and Maladies chroniques, santé perçue, et processus d'adaptation ( APEMAC )
Subjects: Male, MESH: Antirheumatic Agents, MESH: Remission Induction, [SDV]Life Sciences [q-bio], Severity of Illness Index, Arthritis, Rheumatoid, Disability Evaluation, 0302 clinical medicine, Cohen's kappa, Remission criteria, Surveys and Questionnaires, Immunology and Allergy, MESH : Female, 030212 general & internal medicine, MESH : Joints, MESH: Treatment Outcome, MESH: Arthritis, Rheumatoid, MESH: Middle Aged, MESH : Physical Examination, Remission Induction, MESH: Disability Evaluation, MESH : Questionnaires, MESH : Adult, Middle Aged, Joint examination, MESH : Antirheumatic Agents, 3. Good health, MESH: Diagnostic Self Evaluation, MESH: Joints, C-Reactive Protein, Treatment Outcome, Rheumatoid arthritis, Antirheumatic Agents, Cohort, MESH : Severity of Illness Index, Female, MESH : Sensitivity and Specificity, Adult, musculoskeletal diseases, medicine.medical_specialty, MESH : Male, Immunology, MESH : Disability Evaluation, MESH : Treatment Outcome, Sensitivity and Specificity, 03 medical and health sciences, Diagnostic Self Evaluation, MESH: Physical Examination, Rheumatology, Internal medicine, MESH: Severity of Illness Index, MESH: C-Reactive Protein, medicine, Humans, MESH : Middle Aged, Physical Examination, 030203 arthritis & rheumatology, MESH : Remission Induction, MESH: Humans, [ SDV ] Life Sciences [q-bio], MESH : Diagnostic Self Evaluation, business.industry, MESH: Questionnaires, MESH : Humans, MESH: Adult, MESH : C-Reactive Protein, medicine.disease, MESH: Sensitivity and Specificity, MESH: Male, MESH : Arthritis, Rheumatoid, Physical therapy, Joints, business, MESH: Female, Rheumatism, Kappa
Abstract: Objective.To explore 5 possible criteria for remission in rheumatoid arthritis (RA) based on a patient self-report index, the Routine Assessment of Patient Index Data (RAPID3), with a careful joint examination and possible physician global estimate (DOCGL), but without a formal joint count or laboratory test.Methods.The ESPOIR early RA cohort of 813 French patients recruited in 2002–2005 was analyzed to identify patients in remission 6 months after enrollment, according to 2 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria: Boolean ≤ 1 for total tender joint count-28, swollen joint count-28, C-reactive protein, and patient global estimate (PATGL), and Simplified Disease Activity Index (SDAI) ≤ 3.3. Agreement with 7 other remission criteria was analyzed — Disease Activity Score-28 (DAS28) ≤ 2.6, Clinical Disease Activity Index (CDAI) ≤ 2.8, and 5 candidate criteria based on RAPID3, joint examination, and DOCGL: “RAPID3R” (RAPID3 ≤ 3.0); “RAPID3R+SJ1” (RAPID3 ≤ 3.0, ≤ 1 swollen joint); “RAPID3R+SJ1+D1” (RAPID3 ≤ 3.0, ≤ 1 swollen joint, DOCGL ≤ 1); “RAPID3R+SJ0” (RAPID3 ≤ 3.0, 0 swollen joints); and “RAPID3R+SJ0+D1” (RAPID3 ≤ 3.0, 0 swollen joints, DOCGL ≤ 1), according to kappa statistics, sensitivity, and specificity. Residual global, articular, and questionnaire abnormalities according to each criteria set were analyzed.Results.Among 813 ESPOIR patients, 720 had complete data to compare all 9 possible criteria. Substantial agreement with the Boolean criteria was seen for SDAI, CDAI, RAPID3R+SJ1, RAPID3R+SJ1+D1, RAPID3R+SJ0, and RAPID3R+SJ0+D1 (92.2%–94.7%, kappa 0.67–0.79), versus only moderate agreement for DAS28 or RAPID3R (79.9%–85.8%, kappa 0.46–0.55).Conclusion.Remission according to CDAI and RAPID3R+SJ1, but not DAS28 or RAPID3R, is similar to that of the ACR/EULAR criteria. RAPID3 scores require a complementary careful joint examination for clinical decisions, do not preclude formal joint counts or other indices, and may be useful in busy clinical settings.
Published: 2013

14. Atopic sensitization in the first year of life

Author: Markus J. Ege, Erika von Mutius, Juha Pekkanen, Marjut Roponen, Roger Lauener, Jean-Charles Dalphin, Caroline Roduit, Juliane Weber, Josef Riedler, Charlotte Braun-Fahrländer, Martin Depner, Jon Genuneit, Petra Ina Pfefferle, Maija-Riitta Hirvonen, Susanne Krauss-Etschmann, Vincent Kaulek, Institute of Epidemiology, Universität Ulm, Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Asthma and Allergy Department, University Children's Hospital-Ludwig Maximilians University, Universität Ulm - Ulm University [Ulm, Allemagne], Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), University of Zurich, and Depner, Martin
Subjects: Male, Rural Population, Pediatrics, MESH: Maternal-Fetal Exchange, First year of life, medicine.disease_cause, Immunoglobulin E, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, atopic sensitization, early life, environmental exposures, 0302 clinical medicine, Allergen, MESH: Pregnancy, MESH: Rural Population, Pregnancy, Surveys and Questionnaires, Immunology and Allergy, MESH : Female, Maternal-Fetal Exchange, Sensitization, MESH : Allergens, 2. Zero hunger, 0303 health sciences, biology, MESH: Immunoglobulin E, MESH : Questionnaires, MESH : Infant, Fetal Blood, MESH: Infant, 3. Good health, Europe, medicine.anatomical_structure, Cord blood, 2723 Immunology and Allergy, Female, medicine.medical_specialty, MESH: Allergens, MESH: Hypersensitivity, MESH : Male, Immunology, MESH: Environmental Exposure, MESH : Europe, Atopic sensitization, 610 Medicine & health, MESH : Immunoglobulin E, [ SDV.EE.SANT ] Life Sciences [q-bio]/Ecology, environment/Health, 03 medical and health sciences, medicine, Hypersensitivity, Humans, MESH: Fetal Blood, 030304 developmental biology, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, MESH : Fetal Blood, 2403 Immunology, MESH: Humans, MESH : Hypersensitivity, business.industry, MESH: Questionnaires, MESH : Humans, Infant, MESH : Maternal-Fetal Exchange, Odds ratio, Environmental Exposure, Allergens, medicine.disease, MESH: Male, MESH : Rural Population, MESH : Pregnancy, 030228 respiratory system, 10036 Medical Clinic, biology.protein, MESH: Europe, business, MESH: Female, MESH : Environmental Exposure
Abstract: International audience; BACKGROUND: There is conflicting evidence on whether allergen-specific memory is primed prenatally, whether this priming affects persistent immunologic effects, and whether it is modulated by the first environmental exposures in infancy. OBJECTIVE: We sought to explore the course of atopic sensitization between birth and 12 months of age. METHODS: Specific IgE levels for 6 food and 13 common inhalant allergens were assessed in cord blood and 1-year blood samples in the Protection against Allergy-Study in Rural Environments (PASTURE) birth cohort including 793 children from rural regions of 5 European countries. Detailed information on children's health, nutrition, and farm-related exposures was gathered by using a pregnancy questionnaire, 2 questionnaires at 2 and 12 months of age, and a diary covering the time in between. RESULTS: Sensitization was more common at 12 months of age than at birth for almost all specificities. On an individual level, persistent sensitization to the same allergens was rare (1%), whereas transient (only at birth, 11%) and incident (only at 12 months, 34%) sensitization was seen in substantial proportions of children. Associations of transient sensitization with maternal sensitization differed with the allergen specificities, with the strongest associations for food allergens (odds ratio [OR], 10.6; 95% CI, 6.0-18.6) and the weakest associations for seasonal allergens (OR, 1.64; 95% CI, 0.94-2.86). Associations of maternal sensitization with incident sensitization were also seen. Incident sensitization was related to distinct prenatal and postnatal environmental exposures of mother and child, such as consumption of cereals for incident sensitization to seasonal allergens (OR, 0.66; 95% CI, 0.50-0.88). CONCLUSION: IgE sensitization patterns change between birth and 12 months and are related to maternal and environmental influences.
Published: 2013

15. Exposure to an organochlorine pesticide (chlordecone) and development of 18-month-old infants

Author: Christine Monfort, Henri Bataille, Philippe Kadhel, Olivier Boucher, Renée Dallaire, Gina Muckle, Sylvaine Cordier, Luc Multigner, Veronique Chajes, Jean-Pierre Thomé, Florence Rouget, Marie-Noëlle Simard, Centre de recherche du Centre Hospitalier Universitaire de Québec, CHU Québec, Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Génomes et cancer (GC (FRE2939)), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Laboratory of Animal Ecology and Ecotoxicology, Université de Liège, National Institute of Health and Medical Research (Institut National de la Santé et de la Recherche Médicale - INSERM), the National Research Agency (ANR), the French Agency for Environmental and Occupational Health Safety (AFSSET), the National Endocrine Disruptor Research Program of the French Ministry of Environment, the General Health directorate (DGS), the French Institute for Public Health Surveillance., and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Male, Insecticides, Longitudinal study, MESH: Neurotoxicity Syndromes, Physiology, Neuropsychological Tests, 010501 environmental sciences, Toxicology, MESH: Risk Assessment, Nervous System, 01 natural sciences, MESH: Linear Models, MESH: Pregnancy, Pregnancy, Risk Factors, MESH: Risk Factors, Surveys and Questionnaires, MESH: Gestational Age, Medicine, Prospective Studies, Young adult, MESH: Maternal Exposure, Prospective cohort study, Child development, Guadeloupe, 2. Zero hunger, 0303 health sciences, MESH: Milk, Human, General Neuroscience, MESH: Infant, Newborn, Age Factors, Gestational age, MESH: Neuropsychological Tests, MESH: Chlordecone, Fetal Blood, MESH: Infant, MESH: Motor Activity, MESH: Predictive Value of Tests, 3. Good health, Maternal Exposure, Chlordecone, MESH: Young Adult, Prenatal Exposure Delayed Effects, Ages and Stages Questionnaire, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Gestation, Female, Neurotoxicity Syndromes, Cohort study, Adult, Adolescent, Gestational Age, Motor Activity, Breast milk, Risk Assessment, MESH: Prenatal Exposure Delayed Effects, Young Adult, 03 medical and health sciences, Sex Factors, MESH: Sex Factors, Predictive Value of Tests, Humans, MESH: Guadeloupe, MESH: Fetal Blood, 030304 developmental biology, 0105 earth and related environmental sciences, Organochlorine pesticide, MESH: Adolescent, MESH: Age Factors, MESH: Child Development, MESH: Nervous System, MESH: Humans, Milk, Human, business.industry, MESH: Questionnaires, Infant, Newborn, Infant, MESH: Adult, medicine.disease, MESH: Male, MESH: Prospective Studies, MESH: Insecticides, Linear Models, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract: International audience; Chlordecone is a persistent organochlorine pesticide that was used in the French West Indies until the early 1990s for banana weevil borer control. Human exposure to this chemical in this area still occurs nowadays due to consumption of contaminated food. Although adverse effects on neurodevelopment, including tremors and memory deficits, have been documented in experimental studies conducted with rodents exposed during the gestational and neonatal periods, no study has been conducted yet to determine if chlordecone alters child development. This study examines the relation of gestational and postnatal exposure to chlordecone to infant development at 18 months of age in a birth-cohort of Guadeloupean children. In a prospective longitudinal study conducted in Guadeloupe (Timoun mother-child cohort study), exposure to chlordecone was measured at birth from an umbilical cord blood sample (n=141) and from a breast milk sample collected at 3 months postpartum (n=75). Toddlers were assessed using an adapted version of the Ages and Stages Questionnaire. Higher chlordecone concentrations in cord blood were associated with poorer fine motor scores. When analyses were conducted separately for boys and girls, this effect was only observed among boys. These results suggest that prenatal exposure to chlordecone is associated with specific impairments in fine motor function in boys, and add to the growing evidence that exposure to organochlorine pesticides early in life impairs child development.
Published: 2013

16. Quality of Life in Sarcopenia and Frailty

Author: Emmanuel Biver, Yyves Rolland, Jean-Marc Kaufman, Maria-Luisa Brandi, Vincenzo Malafarina, Andrea Laslop, Steven Boonen, Marjolein Visser, Jean-François Arnal, Jean Petermans, Olivier Bruyère, Richard O.C. Oreffo, John A. Kanis, Avan Aihie Sayer, Leocardio Rodgriguez Mañas, Jean-Yves Reginster, Bret H. Goodpaster, Ivan Bautmans, Roger A. Fielding, Cyrus Cooper, René Rizzoli, Heike A. Bischoff-Ferrari, Kieran F. Reid, Arkadi Chines, Yannis Tsouderos, Bruce H. Mitlak, Charlotte Beaudart, Sol Epstein, Gerontology, Frailty in Ageing, Simon, Marie Francoise, Service of Bone Diseases, Université de Genève = University of Geneva (UNIGE)-Geneva University Hospital (HUG), Department of Public Health, Epidemiology and Health Economics, Université de Liège, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Gerontology and Frailty in Ageing Research Department, Vrije Universiteit Brussel (VUB), Centre on Aging and Mobility, Universität Zürich [Zürich] = University of Zurich (UZH), Division of Geriatric Medicine, Leuven University Hospital-Center for Metabolic Bone Diseases, Department of Internal Medicine, Università degli Studi di Firenze = University of Florence (UniFI), General Endocrinology, Amgen Inc., Nutrition, Exercise Physiology and Sarcopenia Laboratory, Tufts University - Human Nutrition Research Center on Aging, Division of Endocrinology, Icahn School of Medicine at Mount Sinai [New York] (MSSM), WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield [Sheffield], Department of Medicine, University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE), Department of Endocrinology, Universiteit Gent = Ghent University (UGENT), Department of Geriatrics, University Hospital of Getafe, Hospital San Juan de Dios, Bone and Joint Research Group, University of Southampton Medical School, Lilly Research Laboratories, Eli Lilly and Company, Gérontopôle, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service of Geriatrics, CHU de Liège, Pharmacology & Toxicology, Austrian Agency for Health and Food Safety (AGES), MRC Lifecourse Epidemiology Unit, University of Southampton, Développement Thérapeutique, Institut de Recherches Internationales Servier [Suresnes] (IRIS), Department of Health Sciences, Vrije Universiteit Amsterdam [Amsterdam] (VU)-VU medisch centrum, Epidemiology and Data Science, EMGO - Lifestyle, overweight and diabetes, Université de Genève (UNIGE)-Geneva University Hospital (HUG), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Amgen Inc. USA, Universiteit Gent = Ghent University [Belgium] (UGENT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse], Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU)-VU medisch centrum, University of Zurich, Rizzoli, René, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, VU University Amsterdam-VU medisch centrum, Nutrition and Health, and EMGO+ - Lifestyle, Overweight and Diabetes
Subjects: Gerontology, Aging, Sarcopenia, Cachexia, 11221 Clinic for Geriatric Medicine, Endocrinology, Diabetes and Metabolism, MESH: Comorbidity, Comorbidity, 0302 clinical medicine, Endocrinology, Quality of life, Surveys and Questionnaires, MESH: Obesity, Orthopedics and Sports Medicine, MESH: Aging, 030212 general & internal medicine, MESH: Sarcopenia, Quality Of Life, MESH: Aged, Frailty, 300 Social sciences, sociology & anthropology, Muscle weakness, humanities, 3. Good health, 1310 Endocrinology, 2712 Endocrinology, Diabetes and Metabolism, Construct (philosophy), Frail Elderly, MEDLINE, 030209 endocrinology & metabolism, elderly, Article, Older population, 03 medical and health sciences, Age, 2732 Orthopedics and Sports Medicine, 360 Social problems & social services, medicine, Humans, Asset (economics), Obesity, Aged, MESH: Humans, business.industry, MESH: Questionnaires, Malnutrition, MESH: Quality of Life, medicine.disease, MESH: Frail Elderly, MESH: Cachexia, ddc:618.97, business
Abstract: The reduced muscle mass and impaired muscle performance that define sarcopenia in older individuals are associated with increased risk of physical limitation and a variety of chronic diseases. They may also contribute to clinical frailty. A gradual erosion of quality of life (QoL) has been evidenced in these individuals, although much of this research has been done using generic QoL instruments, particularly the SF-36, which may not be ideal in older populations with significant comorbidities. This review and report of an expert meeting presents the current definitions of these geriatric syndromes (sarcopenia and frailty). It then briefly summarizes QoL concepts and specificities in older populations and examines the relevant domains of QoL and what is known concerning QoL decline with these conditions. It calls for a clearer definition of the construct of disability, argues that a disease-specific QoL instrument for sarcopenia/frailty would be an asset for future research, and discusses whether there are available and validated components that could be used to this end and whether the psychometric properties of these instruments are sufficiently tested. It calls also for an approach using utility weighting to provide some cost estimates and suggests that a time trade-off study could be appropriate. © 2013 Springer Science+Business Media New York.
Published: 2013

17. Lifecourse socioeconomic position and alcohol use in young adulthood: results from the French TEMPO cohort study

Author: Maria Melchior, Seni Kouanda, Eric Fombonne, Ahmed Yaogo, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department of Psychiatry, Oregon Health and Science University [Portland] (OHSU), Institut de Recherche en Sciences de la Santé, Institut Africain de santé publique, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), This work was supported by grants from the University of Paris South., Schmaus, Annie, and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Adult, Male, MESH: Socioeconomic Factors, Alcohol Drinking, Lifecourse socioeconomic position, Alcohol abuse, Family income, Social class, Article, Developmental psychology, Cohort Studies, MESH: Social Class, Young Adult, Emerging adulthood, Surveys and Questionnaires, medicine, Humans, Longitudinal Studies, Prospective Studies, Young adult, Prospective cohort study, MESH: Longitudinal Studies, MESH: Cohort Studies, Alcohol use patterns, MESH: Humans, MESH: Questionnaires, MESH: Adult, General Medicine, medicine.disease, Educational attainment, MESH: Male, MESH: Prospective Studies, MESH: France, Social Class, Socioeconomic Factors, Longitudinal cohort, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Young Adult, Cohort, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Psychology, MESH: Female, MESH: Alcohol Drinking, Cohort study, Demography
Abstract: International audience; AIMS: The aim of the study was to examine the relationship between lifetime socioeconomic position and alcohol use in young adults. METHODS: The participants (n = 1103, age 22-35 years in 2009) were the French TEMPO cohort, offspring of employees (all French nationals) of the French national gas and electricity company (GAZEL) who were in a previous cohort study. Alcohol use was assessed by the WHO AUDIT questionnaire (none, low or intermediate alcohol use, alcohol abuse). Childhood socioeconomic position was measured using parental income documented in the GAZEL study in 1989 (low: ≤ 2592€/month vs. intermediate/high: >2592€/month). Adult socioeconomic position was measured by participants' educational level (≤ high school degree vs. >high school degree). Combining family income and educational attainment, we ascertained participants' social trajectory (stable high, upward, downward and stable low). Data were analyzed using multinomial regression analyses controlled for demographic, social, psychological and family characteristics. RESULTS: Compared with participants with a stable high social trajectory, those with an upward, downward or low social trajectory were more likely to abstain from alcohol (compared with a stable high social trajectory, sex and age-adjusted ORs: OR = 2.22, 95% CI 1.35-3.65 for an upward social trajectory; OR = 3.20, 95% CI 1.78-5.73 for a downward social trajectory; OR = 3.27, 95% CI 1.75-6.12 for a stable low social trajectory). Additionally, participants with a downward social trajectory were disproportionately likely to abuse alcohol (sex- and age-adjusted OR: 1.48, 95% CI 0.89-2.48). In multivariate analyses, social trajectory remained associated with alcohol use. CONCLUSION: Lifelong socioeconomic position may shape patterns of alcohol use early in life.
Published: 2013

18. Exposure during pregnancy to glycol ethers and chlorinated solvents and the risk of congenital malformations

Author: Sylvaine Cordier, Luc Multigner, Benoit Roig, Juha Pulkkinen, Laurence Labat, Cécile Chevrier, Christine Monfort, Florence Rouget, Nathalie Bonvallot, Ronan Garlantézec, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Laboratoire de Toxicologie et Génopathies, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), École des Hautes Études en Santé Publique [EHESP] (EHESP), Laboratory of Chemistry, University of Eastern Finland, National Institute for Public Health Surveillance (InVS), the French Ministry of Labor, and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Male, Halogenation, Epidemiology, MESH: Solvents, Urine, MESH: Ethylene Glycols, MESH: Occupational Exposure, MESH: Dose-Response Relationship, Drug, chemistry.chemical_compound, 0302 clinical medicine, MESH: Pregnancy, Pregnancy, Surveys and Questionnaires, 030212 general & internal medicine, Prospective Studies, MESH: Maternal Exposure, Prospective cohort study, MESH: Bacterial Proteins, Obstetrics, MESH: Infant, Newborn, Abnormalities, Drug-Induced, MESH: Follow-Up Studies, 030210 environmental & occupational health, MESH: Case-Control Studies, 3. Good health, Glycol ethers, Maternal Exposure, Population Surveillance, Prenatal Exposure Delayed Effects, Cohort, Ethylene Glycols, Female, France, Adult, medicine.medical_specialty, MESH: Abnormalities, Drug-Induced, Urinary system, MESH: Carrier Proteins, MESH: Prenatal Exposure Delayed Effects, MESH: Population Surveillance, 03 medical and health sciences, Bacterial Proteins, Occupational Exposure, medicine, Humans, MESH: Halogenation, MESH: Humans, Dose-Response Relationship, Drug, business.industry, MESH: Questionnaires, Case-control study, Infant, Newborn, MESH: Adult, medicine.disease, MESH: Prospective Studies, MESH: Male, MESH: France, chemistry, Case-Control Studies, Solvents, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Solvent exposure, business, Carrier Proteins, MESH: Female, Follow-Up Studies
Abstract: International audience; BACKGROUND: Exposure to solvents during pregnancy has long been suspected of increasing the risk of congenital malformations, but the lack of prospective assessment of specific solvent exposures has prevented definitive conclusions. METHODS: In a cohort of 3421 pregnant women in Brittany (2002-2006), occupational solvent exposure was assessed from self-report during pregnancy and from a job-exposure matrix. Congenital malformations were diagnosed among live births, stillbirths, and medical pregnancy terminations. In a nested case-control sample, urinary concentrations of 10 metabolites of glycol ethers and chlorinated solvents were measured in maternal samples collected during early pregnancy (n = 79 cases, 580 controls). RESULTS: Dose-response trends linked occupational solvent exposure (both self-reported and based on a job-exposure matrix) to the risk of major congenital malformations--especially oral clefts, urinary tract malformations, and male genital malformations. Detection of some glycol ether metabolites and trichloroacetic acid in urine was associated with increased risks of oral clefts and of urinary tract and limb defects. CONCLUSIONS: This prospective study, using three independent methods of exposure assessment, suggests several specific associations between solvent exposure during early pregnancy and congenital malformations. Results based on urinary biomarkers, although limited by small numbers, identify work situations that require further investigation.
Published: 2012

19. Trajectories of sleep complaints from early midlife to old age: longitudinal modeling study

Author: Yves Dauvilliers, Jane E. Ferrie, Marianna Virtanen, Tasnime N. Akbaraly, Marcel Goldberg, Mika Kivimäki, Martin J. Shipley, Jussi Vahtera, Marie Zins, Jaana Pentti, Archana Singh-Manoux, Paula Salo, Centre of Expertise for the Development of Work and Organizations, Finnish Institute of Occupational Health of Turku-Finnish Institute of Occupational Health of Helsinki, Department of Psychology, University of Turku, Department of Public Health, University of Turku-Turku University Hospital, School of Social and Community Medicine, University of Bristol [Bristol], Department of Epidemiology and Public Health, University College of London [London] (UCL), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), The Finnish Public Sector study was supported by the Academy of Finland (projects 124271, 124322, 129262, and 132944), the New OSH ERA research program. The Whitehall II study is supported by the UK Medical Research Council, the British Heart Foun-dation, the NIH/National Institute on Aging (R01AG013196, R01AG034454) and the National Heart, Lung, and Blood Insti-tute (R01HL036310), USA, and the BUPA Foundation, UK. Dr. Shipley is supported by a grant from the British Heart Founda-tion. The sponsors had no role in designing the study, analyzing or interpreting the data, or preparing the manuscript, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), SZTAJNBOK, Pascale, and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, Gerontology, insomnia, Cohort Studies, 0302 clinical medicine, Surveys and Questionnaires, Epidemiology, Insomnia, Medicine, Sleep initiation and maintenance disorders, Longitudinal Studies, Prospective Studies, Trajectories of Sleep Complaints From Early Mid-Life to Old Age, 030212 general & internal medicine, Prospective cohort study, MESH: Longitudinal Studies, Generalized estimating equation, MESH: Cohort Studies, Finland, ta515, media_common, MESH: Aged, MESH: Middle Aged, MESH: Finland, Confounding, Age Factors, sleep lost due to worry, ta3142, MESH: Follow-Up Studies, Middle Aged, Cohort, MESH: Great Britain, Female, epidemiology, medicine.symptom, Worry, Cohort study, Adult, medicine.medical_specialty, media_common.quotation_subject, 03 medical and health sciences, MESH: Sleep Initiation and Maintenance Disorders, Physiology (medical), Humans, Aged, MESH: Age Factors, MESH: Humans, business.industry, MESH: Questionnaires, MESH: Adult, United Kingdom, MESH: Male, MESH: Prospective Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), business, MESH: Female, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract: International audience; To estimate trajectories of sleep lost over worry as a function of age, using longitudinal modeling, and compare these trajectories with those for insomnia symptoms. Data from two prospective, occupational cohorts (the Whitehall II and Finnish Public Sector studies) comprising 84,384 observations from four to eight repeat measurements in 1985-2010. There were 16,408 men and women age 34-79 yr. Age-related trajectories of sleep lost over worry and insomnia symptoms (sleep initiation or maintenance problems, nonrefreshing sleep) were estimated using repeated-measures log-binomial regression analysis and generalized estimating equations. These analyses were adjusted for year of birth and time of measurement to minimize confounding by cohort or period effects. The prevalence ratio for insomnia symptoms was higher in older age groups compared with participants age 34-45 yr. In contrast, the age-related trajectory of sleep lost over worry included two phases: a period of high prevalence of sleep complaints at age 34-60 yr followed by a declining trajectory at older ages. Compared with participants age 34-45 yr, prevalence ratios for sleep lost over worry were 0.63 (0.49-0.80) and 0.59 (0.41-0.84) in the Whitehall II study participants ages 61-65 and 71-79 years. Corresponding figures were 0.62 (0.52-0.75) and 0.46 (0.32-0.66) in the Finnish Public Sector study. This study shows a general age-related decrease in sleep lost over worry between late midlife and old age, a pattern strikingly different from the age-related increase in insomnia symptoms.
Published: 2012

20. Usefulness of a single-item measure of depression to predict mortality: the GAZEL prospective cohort study

Author: Lefèvre, Thomas, Singh-Manoux, Archana, Stringhini, Silvia, Dugravot, Aline, Lemogne, Cédric, Consoli, Silla, Goldberg, Marcel, Zins, Marie, Nabi, Hermann, Laboratoire de Traitement de l'Information Medicale (LaTIM), Université européenne de Bretagne - European University of Brittany (UEB)-Université de Brest (UBO)-Télécom Bretagne-Institut Mines-Télécom [Paris] (IMT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department of Epidemiology and Public Health, University College of London [London] (UCL), Centre de Gérontologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Sainte Perine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Service Universitaire de Psychiatrie de l'Adulte et du sujet âgé, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Emotion, Université Pierre et Marie Curie - Paris 6 (UPMC)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), The GAZEL cohort study was funded by EDF-GDF and INSERM, and received grants from the Cohortes Santé TGIR Program. ASM is supported by a EUYRI award from the European Science Foundation and the National Institute on Aging, NIH (R01AG013196, and R01AG034454).
Subjects: MESH: Psychiatric Status Rating Scales, MESH: Socioeconomic Factors, MESH: Humans, MESH: Middle Aged, MESH: Depression, MESH: Questionnaires, MESH: Health Behavior, MESH: Adult, MESH: Follow-Up Studies, mortality, MESH: Predictive Value of Tests, MESH: Prospective Studies, MESH: Male, MESH: Cause of Death, MESH: Proportional Hazards Models, MESH: France, MESH: Risk Factors, depression, single-item, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Female
Abstract: International audience; BACKGROUND: It remains unknown whether short measures of depression perform as well as long measures in predicting adverse outcomes such as mortality. The present study aims to examine the predictive value of a single-item measure of depression for mortality. METHODS: A total of 14,185 participants of the GAZEL cohort completed the 20-item Center-for-Epidemiologic-Studies-Depression (CES-D) scale in 1996. One of these items (I felt depressed) was used as a single-item measure of depression. All-cause mortality data were available until 30 September 2009, a mean follow-up period of 12.7 years with a total of 650 deaths. RESULTS: In Cox regression model adjusted for baseline socio-demographic characteristics, a one-unit increase in the single-item score (range 0-3) was associated with a 25% higher risk of all-cause mortality (95% CI: 13-37%, P
Published: 2012

21. LupusQoL-FR is valid to assess quality of life in patients with systemic lupus erythematosus

Author: Jean-François Besancenot, Jean-Loup Pennaforte, Jean-Louis Pasquali, Pierre Kaminsky, Laurent Arnaud, Zahir Amoura, Francis Guillemin, Denis Wahl, Nadine Magy-Bertrand, Christine Binquet, Hervé Devilliers, Bernard Bonnotte, François Maurier, Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques ( CIC-EC ), Université de Bourgogne ( UB ) -Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de Médecine Interne (SOC 1 et SOC 2) [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Service de médecine interne [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Centre National de Référence du Lupus et Syndrome des Antiphospholipides, Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC ( HOTE GREFFON ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Etablissement français du sang [Bourgogne-France-Comté] ( EFS [Bourgogne-France-Comté] ) -Université de Franche-Comté ( UFC ), Service d'Immunologie Clinique, CHU Strasbourg, Immunologie et chimie thérapeutiques ( ICT ), Cancéropôle du Grand Est-Centre National de la Recherche Scientifique ( CNRS ), Service de Médecine Interne et Vasculaire [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Risque cardiovasculaire, rigidité-fibrose et hypercoagulabilité ( RCV ), Université Henri Poincaré - Nancy 1 ( UHP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de médecine interne, Hôpital Sainte-Blandine-Centre hospitalier régional Metz-Thionville ( CHR Metz-Thionville ), Service de Médecine Interne et Maladies Orphelines [CHRU Nancy], Service de Médecine Interne, Hôpital Robert Debré-Centre Hospitalier Universitaire de Reims ( CHU Reims ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Hôpital Jean Minjoz, Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Nancy, Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Ecole de santé publique, Université Paris Descartes - Paris 5 ( UPD5 ) -Nancy Université, Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques (CIC-EC), Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Immunologie et chimie thérapeutiques (ICT), Cancéropôle du Grand Est-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Risque cardiovasculaire, rigidité-fibrose et hypercoagulabilité (RCV), Université Henri Poincaré - Nancy 1 (UHP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville)-Hôpital Sainte-Blandine, Hôpital Robert Debré-Centre Hospitalier Universitaire de Reims (CHU Reims), Service de Médecine interne [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5)-Nancy Université, Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) ( HOTE GREFFON ), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Sainte-Blandine-Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville), Saas, Philippe, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS BFC)-Université de Franche-Comté (UFC)
Subjects: Male, Psychometrics, MESH: Self Report, MESH : Prospective Studies, MESH : Self Report, Severity of Illness Index, 0302 clinical medicine, Surveys and Questionnaires, Medicine, Lupus Erythematosus, Systemic, MESH : Lupus Erythematosus, Systemic, [ SDV.IMM ] Life Sciences [q-bio]/Immunology, Pharmacology (medical), MESH : Female, 030212 general & internal medicine, Prospective Studies, MESH: Translations, MESH: Middle Aged, MESH : Psychometrics, MESH : Questionnaires, Middle Aged, MESH : Adult, MESH: Reproducibility of Results, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, MESH : Severity of Illness Index, Adult, medicine.medical_specialty, SF-36, [SDV.IMM] Life Sciences [q-bio]/Immunology, MESH : Male, MESH : Translations, External validity, 03 medical and health sciences, Rheumatology, Cronbach's alpha, MESH: Psychometrics, MESH: Severity of Illness Index, Humans, Translations, MESH: Lupus Erythematosus, Systemic, MESH : Middle Aged, 030203 arthritis & rheumatology, Rasch model, MESH: Humans, business.industry, MESH: Questionnaires, MESH : Reproducibility of Results, MESH : Humans, Discriminant validity, Construct validity, Reproducibility of Results, MESH: Quality of Life, MESH: Adult, MESH : Quality of Life, MESH: Male, MESH: Prospective Studies, Mann–Whitney U test, Physical therapy, Quality of Life, Self Report, business, MESH: Female
Abstract: International audience; OBJECTIVE: To cross-culturally adapt the LupusQoL into French, to test its measurement properties and to further investigate its domain structure. METHODS: The cultural adaptation process according to guidelines and pre-testing resulted in the LupusQoL-FR. SLE patients completed the LupusQoL-FR at baseline, 15 days, 3 months and 6 months. Validity was studied through content and construct validity (factorial and Rasch analysis for structural validity, Spearman's correlation and Mann-Whitney tests for external validity). Cronbach's α and intra-class correlation coefficients were computed for reliability. The standardized response mean was computed to evaluate responsiveness. RESULTS: In all, 182 patients, age 39.6 (10.6) years, mostly outpatients [mean SELENA-SLEDAI 2.6 (3.5)] were recruited. Factor analysis with eight imposed factors was very close to the original LupusQoL. A screeplot with parallel analysis showed that LupusQoL domains could be aggregated in two physical and mental scales. Both eight- and two-factor structures showed a good Rasch fit, internal consistency (Cronbach's α: 0.85-0.95), and test-retest reliability (intra-class correlation coefficient 0.79-0.95). External convergent (correlation with SF-36, r=0.59-0.78) and divergent validity (according to SELENA-SLEDAI) were also satisfactory. CONCLUSION: The LupusQoL-FR is valid to assess quality of life in SLE patients. A two-factor structure of physical and mental aggregated scales is a valid alternative to the original eight-domain structure.
Published: 2012

22. Prevalence and risk factors for HIV, hepatitis B virus, and syphilis among pregnant women in Mayotte, Indian Ocean, 2008-2009

Author: Philippe Vanhems, Marine Giard, Thomas Bénet, Nicolas Voirin, Abdoulkarim Abaine, Maoulide Saindou, Didier Troalen, Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Service d'Hygiène, Epidémiologie et Prévention [Hôpital Edouard Herriot - HCL], Hôpital Edouard Herriot [CHU - HCL], and Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL)
Subjects: Hemagglutination, [SDV]Life Sciences [q-bio], Human immunodeficiency virus (HIV), HIV Infections, Logistic regression, medicine.disease_cause, Rapid plasma reagin, Comoros, MESH: Comoros, 0302 clinical medicine, MESH: Pregnancy, MESH: Health Surveys, Pregnancy, Risk Factors, MESH: Risk Factors, Surveys and Questionnaires, Prevalence, 030212 general & internal medicine, Pregnancy Complications, Infectious, Treponema, MESH: Middle Aged, medicine.diagnostic_test, biology, Obstetrics and Gynecology, General Medicine, MESH: HIV Infections, Middle Aged, Hepatitis B, 3. Good health, MESH: Young Adult, Population study, Educational Status, Female, Adult, Adolescent, 030231 tropical medicine, 03 medical and health sciences, Young Adult, MESH: Cross-Sectional Studies, medicine, Humans, MESH: Pregnancy Complications, Infectious, Syphilis, MESH: Prevalence, Hepatitis B virus, MESH: Adolescent, Hepatitis B Surface Antigens, MESH: Humans, MESH: Hepatitis B, business.industry, MESH: Questionnaires, MESH: Adult, biology.organism_classification, medicine.disease, Health Surveys, MESH: Hepatitis B Surface Antigens, Cross-Sectional Studies, MESH: Syphilis, Immunology, business, MESH: Educational Status, MESH: Female, Demography
Abstract: International audience; OBJECTIVE: To assess the prevalence and risk factors for HIV, hepatitis B virus (HBV), and syphilis among pregnant women living on the Indian Ocean island of Mayotte. METHODS: A cross-sectional survey was conducted among 671 pregnant women at 11 prenatal clinics on Mayotte between September 15, 2008, and September 27, 2009. Sociodemographic and behavioral characteristics were collected by interviewer-administered questionnaire. Blood samples were obtained for HIV, HBV, and syphilis testing. Risk factors were analyzed by exact logistic regression. RESULTS: No prevalent case of HIV infection was detected among the study population. The prevalence of HBV surface antigen and active syphilis (defined as a positive test result by both rapid plasma reagin and Treponema pallidum hemagglutination assays) was 3.4% and 2.1%, respectively. A positive HBV surface antigen test was associated with being born in Comoros and having sex with a casual partner during the previous year. Lack of education and a history of sexually transmitted infections in the past 5 years were associated with active syphilis. CONCLUSION: The continuing low prevalence of HIV and high prevalence of sexually transmitted infections among pregnant women on Mayotte confirmed the so-called "Indian Ocean paradox."
Published: 2012

23. Prevalence case-control study of epilepsy in three Burkina Faso villages

Author: Zekiba Tarnagda, Pierre Dorny, Pascal Nitiéma, Linda D. Cowan, Athanase Millogo, Efécab, Rasmané Ganaba, Sennen Hounton, C. Kompaoré, Nicolas Praet, Hélène Carabin, IRSS, Institut de Recherche en Science de la santé, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), and EFECAB
Subjects: Male, Rural Population, Veterinary medicine, Africa, West, Cross-sectional study, MESH: Logistic Models, Associations, Logistic regression, Epilepsy, 0302 clinical medicine, MESH: Rural Population, MESH: Risk Factors, Surveys and Questionnaires, Zoonoses, MESH: Child, Epidemiology, Taenia solium, Prevalence, Child, 2. Zero hunger, Farmers, MESH: Middle Aged, Age Factors, MESH: Enzyme-Linked Immunosorbent Assay, Cysticercosis, Helminthic diseases, General Medicine, Middle Aged, Ag-ELISA, 3. Good health, medicine.drug_formulation_ingredient, Neurology, MESH: Young Adult, MESH: Epilepsy, Female, Pigs, MESH: Antigens, Age distribution, Adult, medicine.medical_specialty, Meat, Adolescent, Consumption, 030231 tropical medicine, Enzyme-Linked Immunosorbent Assay, Article, 03 medical and health sciences, Young Adult, MESH: Cross-Sectional Studies, Burkina Faso, medicine, Humans, Serologic Tests, MESH: Burkina Faso, Antigens, MESH: Prevalence, Retrospective Studies, MESH: Adolescent, MESH: Age Factors, MESH: Humans, business.industry, MESH: Questionnaires, MESH: Serologic Tests, MESH: Adult, MESH: Retrospective Studies, Odds ratio, medicine.disease, MESH: Male, Cross-Sectional Studies, Logistic Models, Risk factors, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), business, Estimation, MESH: Female, MESH: Cysticercosis, 030217 neurology & neurosurgery, Demography, Blood sampling
Abstract: International audience; PURPOSE: To estimate the association between the prevalence of epilepsy and potential risk factors in three Burkina Faso villages. METHODS: Three villages were selected based on local reports of high numbers of epilepsy cases and pig-rearing practices. One person aged 7 or older was selected at random from all households of selected concessions for epilepsy screening and blood sampling. Epilepsy was confirmed by a physician using the ILAE definition. The cross-sectional associations between epilepsy and selected factors and seroresponse to the antigens of Taenia solium were estimated using a Bayesian hierarchical logistic regression. Prevalence odds ratios (POR) and their 95% Bayesian Credible Intervals (95% BCI) were estimated. RESULTS: Of 888 individuals interviewed, 39 of 70 screened positive were confirmed to have epilepsy for a lifetime prevalence of 4.5% (95% CI: 3.3; 6.0). The prevalence of epilepsy was associated with a positive reaction to cysticercosis Ag-ELISA serology (POR = 3.1, 95% BCI = 1.0; 8.3), past pork consumption (POR = 9.7, 95% BCI = 2.5; 37.9), and being salaried or a trader compared to a farmer or housewife (POR = 2.9, 95% BCI = 1.2; 6.4). DISCUSSION: Several factors were associated with prevalent epilepsy, with Ag-ELISA suggesting the presence of neurocysticercosis. The association between epilepsy and some occupations may reflect differences in local attitudes toward epilepsy and should be further explored.
Published: 2012

24. Risk factors in facial hyperpigmentation in Maghrebian population - a case-control study

Author: H. Benchikhi, H. Lakhdar, N. Atide, I. Jroundi, P. Humbert, Service de Dermatologie, CHU Ibn Rochd [Casablanca], Département de santé publique, Faculté de Médecine Rabat, Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), and Saas, Philippe
Subjects: Adult, Male, Aging, medicine.medical_specialty, [SDV.IMM] Life Sciences [q-bio]/Immunology, Population, Dark skin, Pharmaceutical Science, Dermatology, Menstruations, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Colloid and Surface Chemistry, Hyperpigmentation, Risk Factors, MESH: Risk Factors, Surveys and Questionnaires, Drug Discovery, Humans, Medicine, 030212 general & internal medicine, education, hirsutism, Acne, Pregnancy, education.field_of_study, MESH: Humans, business.industry, MESH: Questionnaires, Case-control study, MESH: Adult, medicine.disease, Phototype, MESH: Case-Control Studies, MESH: Hyperpigmentation, MESH: Male, 3. Good health, Morocco, Chemistry (miscellaneous), Case-Control Studies, Face, MESH: Morocco, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, business, MESH: Face, MESH: Female
Abstract: International audience; Triggering factors seem to be multiple in the pathogenesis of facial hyperpigmentation (FH), as dark skin types, pregnancy, sun exposure... The aim of this study was to investigate the risk factors for FH in Maghrebian population. Patients with FH were included in a case-controlled study. Following data were recorded: age, sex, parity, phototype, FH and hormonal-related history, endocrinological features, sunlight exposure, specific cultural behaviours, use of topic corticosteroids and sunscreens. One hundred women (mean age 29.5 ± 13.7 years) were included with 200 age-matched controls. Duration of FH was 32.9 ± 42.2 months. There was a statistically significant relation between FH and hirsutism (P = 0.009), troubles of menstruations (P = 0.008), but not with acne (P = 0.23) and contraceptive oral (P = 0.06) drugs or with history of thyroid disorders (P = 0.13). For cultural factors, there were a statistical significant relation with rubbing by flannel glove (P < 0.05), use of dark soap (P = 0.009) and traditional masks (P < 0.05) but both groups were used to go to hammam. A strong relation was observed between FH and use of topical corticosteroids: 40% in the FH group vs. 5% in the control group (P < 0.05). Both groups used to apply sunscreens: 70% in the FH group and 67% in the control group where as there were no differences in the two groups for sun exposure. No statistical differences were observed regarding to age, phototypes and grade of parity. Our study demonstrated a relation between FH and hyperestrogenemia, rubbing with a friction glove, use of moroccan traditional masks and application of topical steroids. The eviction of all these triggering factors could be an adjuvant recommendation in the assessment of FH.
Published: 2012

25. A risk assessment of campylobacteriosis and salmonellosis linked to chicken meals prepared in households in Dakar, Senegal

Author: Régis, Pouillot, Benoit, Garin, Noro, Ravaonindrina, Kane, Diop, Mahery, Ratsitorahina, Domoina, Ramanantsoa, Jocelyne, Rocourt, 7403 Wyndale Lane, Wyndale Lane, Institut Pasteur de Dakar, Réseau International des Instituts Pasteur (RIIP), Institut Pasteur de Madagascar, Département des Sciences et médecines vétérinaires, Faculté de Médecine, Centre de Recherche Médicale et Sanitaire (Niamey, Niger) (CERMES), and This work was supported by a project fund (ACIP) from the Paris Pasteur Institute.
Subjects: Meat, Food Handling, [SDV]Life Sciences [q-bio], Food Contamination, MESH: Bacterial Load, MESH: Risk Assessment, Models, Biological, Risk Assessment, Foodborne Diseases, MESH: Campylobacter Infections, MESH: Senegal, Surveys and Questionnaires, Campylobacter Infections, Animals, Humans, MESH: Hygiene, MESH: Animals, Cooking, MESH: Food Microbiology, MESH: Foodborne Diseases, Developing Countries, MESH: Developing Countries, MESH: Meat, MESH: Salmonella Food Poisoning, MESH: Humans, MESH: Questionnaires, digestive, oral, and skin physiology, MESH: Models, Biological, MESH: Chickens, Hygiene, MESH: Cooking, MESH: Food Contamination, Bacterial Load, Senegal, Food Microbiology, Salmonella Food Poisoning, Public Health, MESH: Public Health, Chickens, MESH: Food Handling
Abstract: International audience; We used a quantitative microbiological risk assessment model to describe the risk of Campylobacter and Salmonella infection linked to chicken meals prepared in households in Dakar, Senegal. The model uses data collected specifically for this study, such as the prevalence and level of bacteria on the neck skin of chickens bought in Dakar markets, time-temperature profiles recorded from purchase to consumption, an observational survey of meal preparation in private kitchens, and detection and enumeration of pathogens on kitchenware and cooks' hands. Thorough heating kills all bacteria present on chicken during cooking, but cross-contamination of cooked chicken or ready-to-eat food prepared for the meal via kitchenware and cooks' hands leads to a high expected frequency of pathogen ingestion. Additionally, significant growth of Salmonella is predicted during food storage at ambient temperature before and after meal preparation. These high exposures lead to a high estimated risk of campylobacteriosis and/or salmonellosis in Dakar households. The public health consequences could be amplified by the high level of antimicrobial resistance of Salmonella and Campylobacter observed in this setting. A significant decrease in the number of ingested bacteria and in the risk could be achieved through a reduction of the prevalence of chicken contamination at slaughter, and by the use of simple hygienic measures in the kitchen. There is an urgent need to reinforce the hygiene education of food handlers in Senegal.
Published: 2012

26. Epilepsy-associated stigma in Bolivia: a community-based study among the Guarani population: an International League Against Epilepsy/International Bureau for Epilepsy/World Health Organization Global Campaign Against Epilepsy Regional Project

Author: Elisa, Bruno, Alessandro, Bartoloni, Vito, Sofia, Florentina, Rafael, Donata, Magnelli, Sandra, Padilla, Graziella, Quattrocchi, Filippo, Bartalesi, Higinio, Segundo, Mario, Zappia, Pierre-Marie, Preux, Alessandra, Nicoletti, Department of Neurosciences, Università degli studi di Catania [Catania], Neuroépidémiologie Tropicale et Comparée (NETEC), Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Université de Limoges (UNILIM), Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, and Université de Limoges (UNILIM)
Subjects: Adult, Male, Bolivia, Social Stigma, Global Health, MESH: International Agencies, Young Adult, MESH: Aged, 80 and over, Residence Characteristics, Surveys and Questionnaires, Humans, MESH: Residence Characteristics, Aged, Aged, 80 and over, MESH: Aged, Epilepsy, MESH: Humans, MESH: Middle Aged, MESH: Questionnaires, International Agencies, MESH: Adult, Middle Aged, MESH: Male, MESH: Bolivia, MESH: Young Adult, MESH: Epilepsy, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Social Stigma, MESH: Female, MESH: World Health
Abstract: International audience; Epilepsy is associated with a significant burden of social stigma that appears to be influenced by psychosocial and cultural factors. Stigma has a negative effect on the management of people with epilepsy (PWE), representing one of the major factors that contribute to the burden of epilepsy. To assess stigma perception among the Guarani population, one hundred thirty-two people living in Guaraní communities in Bolivia were invited to complete the Stigma Scale of Epilepsy questionnaire. The main determinants of stigma identified were: the fear linked to loss of control, the feelings of sadness and pity toward PWE, the difficulties faced by PWE in the professional and relationship fields, the level of education and type of seizure. Our study pointed out that, in this population, PWE face difficulties in everyday life because of epilepsy-associated stigma and the results attest to the importance of promoting community-based educational programs aimed at reducing the stigmatization process.
Published: 2012

27. The latest news about the ESCeL Platform

Author: Jean Fajadet, Lino Gonçalves, Martine Gilard, Cardiology Department, Coimbra University Hospital and Medical School, Optimisation des régulations physiologiques (ORPHY (EA 4324)), Institut Brestois Santé Agro Matière (IBSAM), and Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)
Subjects: MESH: Humans, business.industry, MESH: Questionnaires, MESH: Health Knowledge, Attitudes, Practice, MESH: Societies, Medical, 030204 cardiovascular system & hematology, MESH: Cardiology, World Wide Web, 03 medical and health sciences, 0302 clinical medicine, MESH: Internet, MESH: Education, Distance, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Medicine, The Internet, 030212 general & internal medicine, MESH: Europe, Cardiology and Cardiovascular Medicine, business, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2012

28. Association of environmental insecticide exposure and fetal growth with a Bayesian model including multiple exposure sources: the PELAGIE mother-child cohort

Author: François Coquet, Claire Petit, Marta Blangiardo, Sylvaine Cordier, Cécile Chevrier, Sylvia Richardson, Institut de recherche, santé, environnement et travail ( Irset ), Université d'Angers ( UA ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -École des Hautes Études en Santé Publique [EHESP] ( EHESP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) -Université des Antilles ( UA ), Department of Epidemiology and Public Health, Imperial College Norfolk Place, Institut de Recherche Mathématique de Rennes ( IRMAR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -AGROCAMPUS OUEST-École normale supérieure - Rennes ( ENS Rennes ) -Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National des Sciences Appliquées ( INSA ) -Université de Rennes 2 ( UR2 ), Université de Rennes ( UNIV-RENNES ) -Centre National de la Recherche Scientifique ( CNRS ), Ecole Nationale de la Statistique et de l'Analyse de l'Information ( ENSAI ), Ensai, Ecole Nationale de la Statistique et de l'Analyse de l'Information, the National Institute for Public Health Surveillance, the Ministry of Labor, the Regional Health Department of the Brittany region, a fellowship from GlaxoSmithKline., Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Institut de Recherche Mathématique de Rennes (IRMAR), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Ecole Nationale de la Statistique et de l'Analyse de l'Information [Bruz] (ENSAI), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École normale supérieure - Rennes (ENS Rennes)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École normale supérieure - Rennes (ENS Rennes)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-INSTITUT AGRO Agrocampus Ouest
Subjects: multiple sources, MESH : Insecticides, Insecticides, Epidemiology, agricultural activities, 010501 environmental sciences, MESH : Agriculture, 01 natural sciences, Cohort Studies, Fetal Development, Toxicology, 0302 clinical medicine, MESH: Pregnancy, Pregnancy, Surveys and Questionnaires, Credible interval, Fetal growth, MESH : Female, 030212 general & internal medicine, MESH: Maternal Exposure, MESH: Cohort Studies, 2. Zero hunger, MESH : Head, MESH: Infant, Newborn, MESH : Models, Statistical, MESH: Diet Surveys, MESH : Questionnaires, Agriculture, MESH : Maternal Exposure, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Follow-Up Studies, MESH : Adult, insecticide exposure, household use, Maternal Exposure, MESH: Young Adult, Cohort, head circumference, MESH: Head, Female, France, MESH: Agriculture, MESH: Fetal Development, Adult, Multiple exposure, Adolescent, Birth weight, MESH: Bayes Theorem, MESH : Young Adult, MESH : Cohort Studies, Biology, MESH : Infant, Newborn, Diet Surveys, Young Adult, 03 medical and health sciences, MESH : Bayes Theorem, Environmental health, MESH : Adolescent, Humans, MESH: Birth Weight, Latent variable model, MESH : France, 0105 earth and related environmental sciences, MESH: Adolescent, Models, Statistical, MESH: Humans, business.industry, MESH: Questionnaires, MESH : Humans, Infant, Newborn, birth weight, Bayes Theorem, MESH: Adult, MESH : Birth Weight, MESH : Follow-Up Studies, Bayesian modeling, MESH: Insecticides, MESH: France, MESH : Pregnancy, MESH : Fetal Development, Residence, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, diet, MESH : Diet Surveys, Head, MESH: Female, MESH: Models, Statistical, Follow-Up Studies
Abstract: International audience; It has been suggested that prenatal exposure to insecticides adversely affects fetal growth, but the overall results have been inconsistent, partly because of the different exposure sources and exposure assessments used. In the French PELAGIE (Perturbateurs Endocriniens: Étude Longitudinale sur les Anomalies de la Grossesse, l'Infertilité et l'Enfance) mother and child cohort (2002-2006), the authors investigated the association between fetal growth and insecticide exposure (n = 1,213) using an integrated Bayesian latent variable model to include multiple exposure sources: agricultural activities, nonorganic diet, household insecticide use on plants, and household insecticide use against insects. They used a questionnaire to collect information on household use and organic diet, and a national agricultural census provided data on agricultural activities in the women's municipalities of residence. A 0.10-cm decrease in head circumference at birth (95% credibility interval: -0.22, 0.01) was associated with fetal insecticide exposure from agricultural activities in the municipality of residence. Decreases in average birth weight (-27 g; 95% credibility interval: -59, 6) and head circumference (-0.12 cm; 95% credibility interval: -0.26, 0.01) were associated with household insecticide use to treat plants. The present results suggest an inverse association between fetal growth and prenatal insecticide exposure from nearby agricultural activity or household use. Bayesian modeling via latent variables is a natural framework for including multiple sources of exposure to environmental pollutants.
Published: 2012

29. Quality of life of early school-age French children born preterm: a cohort study

Author: Pascal Auquier, Marie-Ange Einaudi, Catherine Gire, Véronique Brévaut-Malaty, Marie-Claude Simeoni, Julie Berbis, Claude D'Ercole, Santé Publique et maladies Chroniques : Qualité de vie Concepts, Usages et Limites, Déterminants (SPMC), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM), Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Département de Pédiatrie-Néonatologie, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Laboratoire de Santé Publique, Université de la Méditerranée - Aix-Marseille 2, Service d'Obstétrique-Gynécologie [Marseille], and Assistance Publique - Hôpitaux de Marseille (APHM)-CHU Marseille- Hôpital Nord [CHU - APHM]
Subjects: Male, Multivariate analysis, Health Status, Neuropsychological Tests, Vitality, Cohort Studies, 0302 clinical medicine, Surveys and Questionnaires, MESH: Child, Medicine, 030212 general & internal medicine, 10. No inequality, Child, MESH: Cohort Studies, MESH: Health Status, Schools, medicine.diagnostic_test, MESH: Infant, Newborn, Obstetrics and Gynecology, MESH: Neuropsychological Tests, MESH: Follow-Up Studies, 3. Good health, Cohort, Gestation, Female, France, Infant, Premature, Cohort study, MESH: Infant, Premature, medicine.medical_specialty, MESH: Socioeconomic Factors, MESH: Schools, Birth weight, Physical examination, MESH: Social Class, 03 medical and health sciences, 030225 pediatrics, Humans, Psychiatry, MESH: Humans, business.industry, MESH: Questionnaires, Infant, Newborn, MESH: Quality of Life, MESH: Male, [SDV.ETH]Life Sciences [q-bio]/Ethics, MESH: France, MESH: Cognition Disorders, Reproductive Medicine, Social Class, Socioeconomic Factors, Quality of Life, business, Cognition Disorders, Neurocognitive, MESH: Female, Demography, Follow-Up Studies
Abstract: International audience; OBJECTIVES: To describe the health-related quality of life (HRQL) of a cohort of children aged 6-10 years who were born preterm; and to determine whether sociodemographic factors, neonatal features and neurocognitive status were affecting their HRQL. STUDY DESIGN: All singleton infants born between 24 and 32 weeks of gestation between January 1997 and December 2001 at the study hospital, who were still alive in 2007 (age 6-10 years), and who had undergone complete clinical paediatric follow-up were included in the study. Maternal and perinatal data were obtained by chart review and regular clinical examination. The 'Battery for Rapid Evaluation of Cognitive Functions' (BREV) was used for cognitive evaluation when children were aged 4-8 years. HRQL data were collected in 2007 using the 'Vécu et Santé Perçue de l'Adolescent et de l'Enfant' (VSP-A) questionnaire (parent version). The HRQL of the preterm children was compared with that of a French reference population. RESULTS: Of 202 children who fulfilled the inclusion criteria, 82 children participated in the study. Their mean age was 7.9 years [standard deviation (SD) 1.4], mean birth weight was 1130.0 g (SD 361.4), 23 children were born before 28 weeks of gestation, 46 were female and 11 had major neurocognitive disorders. These data were not significantly different for the non-respondents (n=120). Parents of preterm children reported a significantly lower perception of HRQL of their child compared with parents of children in the reference population, as reflected by VSP-A global index scores and scores for the 'body image', 'vitality', 'psychological well-being' and 'school performance' dimensions. In multivariate analyses, three factors were found to be significantly associated with at least one dimension in the VSP-A scale in the preterm children: presence of major neurocognitive disorders, negatively correlated with 'vitality', 'relationships with friends', 'physical well-being' and 'school performance' dimensions; maternal parity, positively correlated with the 'psychological well-being' dimension; and socio-economic status of family, positively correlated with the 'relationships with friends' dimension. The maximum R(2) was 15%. CONCLUSION: In addition to neurocognitive disorders, other variables such as socio-economic status of the family have a significant impact on the HRQL of preterm children at 6-10 years of age. Given the low proportion of variability in HRQL explained by the models, there is a need to explore other factors (e.g. environmental).
Published: 2012

30. Long-term outcome of patients presenting with acute infectious encephalitis of various causes in France

Author: Benoit Guery, Jean-Louis Herrmann, Alexandra Mailles, Bruno Lina, Jean Paul Stahl, Daniel Terral, Marc Lecuit, Cecile Bebear, Bruno POZZETTO, Virginie Prendki, Département des maladies infectieuses, Institut de Veille Sanitaire (INVS), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Service de maladies infectieuses et tropicales, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), French Society for Infectious Diseases (Société de Pathologie Infectieuse de Langue Française [SPILF]), the French Institute for Public Health Surveillance (Institut de Veille Sanitaire [InVS]), Steering Committee and Investigators Group, and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Male, Pediatrics, Behavioral Symptoms, 0302 clinical medicine, MESH: Aged, 80 and over, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Surveys and Questionnaires, MESH: Child, Prevalence, Infectious encephalitis, Prospective Studies, 030212 general & internal medicine, Child, Prospective cohort study, MESH: Treatment Outcome, Aged, 80 and over, MESH: Aged, MESH: Middle Aged, Glasgow Outcome Scale, MESH: Behavioral Symptoms, Middle Aged, MESH: Interviews as Topic, MESH: Memory Disorders, MESH: Infant, 3. Good health, Treatment Outcome, Infectious Diseases, MESH: Young Adult, Child, Preschool, Cohort, Encephalitis, Female, France, Adult, Microbiology (medical), medicine.medical_specialty, MESH: Speech Disorders, MESH: Persistent Vegetative State, Adolescent, MESH: Attention Deficit Disorder with Hyperactivity, Speech Disorders, Interviews as Topic, Young Adult, 03 medical and health sciences, Informant Questionnaire on Cognitive Decline in the Elderly, medicine, Humans, MESH: Prevalence, Aged, MESH: Adolescent, Memory Disorders, MESH: Humans, business.industry, Persistent Vegetative State, MESH: Questionnaires, MESH: Child, Preschool, Infant, MESH: Adult, medicine.disease, Comorbidity, MESH: Male, MESH: Prospective Studies, MESH: France, Attention Deficit Disorder with Hyperactivity, Physical therapy, Etiology, MESH: Encephalitis, business, MESH: Female, 030217 neurology & neurosurgery
Abstract: International audience; BACKGROUND: A prospective study of infectious encephalitis was conducted in France in 2007. In total, 253 patients were enrolled with a proven etiological diagnosis for 52%. The cohort of surviving patients with encephalitis was assessed for sequelae and impairment 3 years after enrollment. METHODS: Patients, their family, and general practitioners (GPs) were interviewed by phone to document persisting symptoms, return to work, and past and current leisure activities, with standardized questionnaires. The IQCODE (Informant Questionnaire on Cognitive Decline in the Elderly) was completed with relatives. The global outcome was determined in all patients with the Glasgow outcome scale. RESULTS: In 2010, 20 patients (10%) were unavailable for follow-up, 2 (1%) were excluded, and 18 (9%) had died since hospital discharge. Data were available for 167 survivors and 9 patients whose death was related to the encephalitis. The outcome was favorable in 108 of 176 patients (61%) (71 with complete resolution), 31 (18%) were mildly impaired, 25 (14%) were severely impaired, and 3 (1%) were in a vegetative state. The most frequent symptoms were difficulty concentrating (42%), behavioral disorders (27%), speech disorders (20%), and memory loss (19%). Fifteen of 63 patients (24%) previously employed were still unable to resume work. Long-term outcome was significantly associated with comorbid conditions, age, level of education, and the causative agent of encephalitis. CONCLUSIONS: Most patients with encephalitis experienced a favorable outcome 3 years after hospital discharge. However, minor to severe disability persists in a high number of cases with consequences for everyday life. Physical and mental impairment should be evaluated in all patients with encephalitis, and neuropsychological rehabilitation implemented whenever needed.
Published: 2012

31. Prevalence of electrocardiographic abnormalities in West-Asian and African male athletes

Author: François Carré, Bruce A. Hamilton, Jean-Claude Chatard, Sanjay Sharma, Greg Whyte, Mathew G Wilson, Hakim Chalabi, Department of Sports Medicine, Qatar Orthopaedic and Sports Medicine Hospital-ASPETAR, Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, Cardiomyopathy, Disease, 030204 cardiovascular system & hematology, Electrocardiography, 0302 clinical medicine, MESH: Early Diagnosis, Surveys and Questionnaires, MESH: Child, Prevalence, Orthopedics and Sports Medicine, Young adult, Child, MESH: Athletes, biology, medicine.diagnostic_test, MESH: Heart Diseases, General Medicine, MESH: European Continental Ancestry Group, MESH: Qatar, MESH: Young Adult, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Adult, medicine.medical_specialty, Adolescent, Heart Diseases, Black People, Physical Therapy, Sports Therapy and Rehabilitation, Physical examination, Sudden death, White People, Young Adult, 03 medical and health sciences, MESH: Physical Examination, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, medicine, Humans, National level, Physical Examination, Qatar, MESH: Prevalence, MESH: Adolescent, MESH: Humans, Athletes, business.industry, MESH: Questionnaires, MESH: Adult, MESH: Death, Sudden, Cardiac, Original Articles, 030229 sport sciences, biology.organism_classification, medicine.disease, MESH: Male, MESH: Electrocardiography, Death, Sudden, Cardiac, Early Diagnosis, Physical therapy, MESH: African Continental Ancestry Group, business
Abstract: International audience; OBJECTIVES: To evaluate the electrocardiographic (ECG) characteristics of West-Asian, black and Caucasian male athletes competing in Qatar using the 2010 recommendations for 12-lead ECG interpretation by the European Society of Cardiology (ESC). DESIGN: Cardiovascular screening with resting 12-lead ECG analysis of 1220 national level athletes (800 West-Asian, 300 black and 120 Caucasian) and 135 West-Asian controls was performed. RESULTS: Ten per cent of athletes presented with 'uncommon' ECG findings. Black African descent was an independent predictor of 'uncommon' ECG changes when compared with West-Asian and Caucasian athletes (p0.05). Seven athletes (0.6%) were identified with a disease associated with sudden death; this prevalence was two times higher in black athletes than in West-Asian athletes (1% vs 0.5%), and no cases were reported in Caucasian athletes and West-Asian controls. Eighteen West-Asian and black athletes were identified with repolarisation abnormalities suggestive of a cardiomyopathy, but ultimately, none were diagnosed with a cardiac disease. CONCLUSION: West-Asian and Caucasian athletes demonstrate comparable rates of ECG findings. Black African ethnicity is positively associated with increased frequencies of 'uncommon' ECG traits. Future work should examine the genetic mechanisms behind ECG and myocardial adaptations in athletes of diverse ethnicity, aiding in the clinical differentiation between physiological remodelling and potential cardiomyopathy or ion channel disorders.
Published: 2012

32. Investigation of a sudden malaria outbreak in the isolated Amazonian village of Saul, French Guiana, January-April 2009

Author: Jacques Rosine, Claude Flamand, Isabelle Dusfour, Vanessa Ardillon, Félix Djossou, Patrick Rabarison, Franck Berger, Claire Grenier, Marie-Anne Sanquer, Lise Musset, Eric Legrand, Romain Girod, Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Cellule Interrégionale d'Epidémiologie Antilles-Guyane, Cellule interrégionale d'épidémiologie Antilles-Guyane [CIRE], Laboratoire de Parasitologie Mycologie, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Agence Régionale de Santé de Guyane, Direction de la Démoustication et des Actions Sanitaires, Conseil Général de la Guyane, Département des Centres de Santé, This study was supported by the Institut de Veille Sanitaire (agreement no. 08-S-IT-P30-02) and the Agence Regionale de Sante de Guyane (agreement 041/DSDS-DSE-2008)., Laboratoire de Parasitologie [Cayenne, Guyane française], Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), Agence Régionale de Santé Guyane (ARS Guyane), and Agence Régionale de la Santé (ARS)
Subjects: Male, Insecticides, Attack rate, Plasmodium vivax, Disease Outbreaks, 0302 clinical medicine, MESH: Aged, 80 and over, Surveys and Questionnaires, MESH: Child, MESH: Animals, MESH: Incidence, MESH: Disease Outbreaks, Socioeconomics, Child, MESH: Plasmodium falciparum, Aged, 80 and over, MESH: Aged, 0303 health sciences, MESH: Middle Aged, biology, Ecology, Transmission (medicine), Incidence, Anopheles, Articles, Middle Aged, MESH: Infant, 3. Good health, French Guiana, MESH: Plasmodium vivax, Infectious Diseases, MESH: Young Adult, Child, Preschool, Female, Adult, Adolescent, MESH: Population Density, 030231 tropical medicine, Plasmodium falciparum, MESH: Malaria, MESH: Insect Vectors, MESH: Anopheles, 03 medical and health sciences, Young Adult, Virology, parasitic diseases, MESH: French Guiana, medicine, Animals, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Aged, Retrospective Studies, Population Density, MESH: Adolescent, MESH: Humans, 030306 microbiology, MESH: Questionnaires, MESH: Child, Preschool, Outbreak, Infant, MESH: Adult, MESH: Retrospective Studies, biology.organism_classification, medicine.disease, MESH: Male, Insect Vectors, Malaria, MESH: Insecticides, Vector (epidemiology), Parasitology, MESH: Female
Abstract: International audience; Malaria is endemic in French Guiana. Plasmodium falciparum and Plasmodium vivax are the predominant species responsible and Anopheles darlingi is described as the major vector. In mid-August 2008, an increase in malaria incidence was observed in Saül. A retrospective cohort survey was performed. In vitro susceptibility profiles to antimalarials were determined on P. falciparum isolates. Collections of mosquitoes were organized. The malaria attack rate reached 70.6/100. The risk of malaria increased for people between 40 and 49 years of age, living in a house not subjected to a recent indoor residual insecticide spraying or staying overnight in the surrounding forest. All isolates were susceptible. Anopheles darlingi females and larvae were collected in the village suggesting a local transmission. Our results strongly support a role of illegal mining activities in the emergence of new foci of malaria. Therefore, public health authorities should define policies to fight malaria at a transborder level.
Published: 2012

33. Prevalence of hypertension and associated risk factors in Benin

Author: Akpa R. Gbary, Yessito Corine Houehanou, Alphonse Kpozehouen, Dismand Houinato, François Djrolo, Roger Salamon, J. Segnon-Agueh, M. Amoussou, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité d'Enseignement et de Recherche de Neurologie (UER neurologie FSS), University of Abomey Calavi (UAC), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), and Université Bordeaux Segalen - Bordeaux 2
Subjects: Male, Pediatrics, Multivariate analysis, Epidemiology, Cross-sectional study, Blood Pressure, 030204 cardiovascular system & hematology, MESH: Hypertension, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, Surveys and Questionnaires, Prevalence, Benin, Medicine, 030212 general & internal medicine, education.field_of_study, MESH: Middle Aged, Anthropometry, MESH: Blood Pressure, Middle Aged, 3. Good health, Cardiovascular Diseases, Population Surveillance, Hypertension, Female, Adult, medicine.medical_specialty, Population, MESH: Multivariate Analysis, MESH: Population Surveillance, 03 medical and health sciences, MESH: Benin, MESH: Cross-Sectional Studies, MESH: Anthropometry, Environmental health, Humans, Risk factor, education, MESH: Prevalence, MESH: Humans, business.industry, MESH: Questionnaires, Public Health, Environmental and Occupational Health, MESH: Cardiovascular Diseases, MESH: Adult, medicine.disease, Obesity, MESH: Male, Cross-Sectional Studies, Blood pressure, Multivariate Analysis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract: International audience; BACKGROUND: Hypertension is one of the main risk factors of cardiovascular diseases. There has been a lack of data on this risk factor in the general population in Benin. The aim of this study was to determine the prevalence of hypertension and identify the associated risk factors in Benin. METHODS: A cross-sectional study was conducted from July to August 2008 in Benin's 12 departments. The questionnaire and anthropometric measurements of the World Health Organization STEPWISE survey were used. The sample included 6853 subjects 25-64 years of age, randomly selected by five-stage random sampling. Blood pressure was measured using standard procedures. Data was processed and analyzed using EPI DATA and STATA 9.2 software. Prevalence levels were compared using Pearson's chi(2) and means with the Student t-test. Univariate and multivariate regression analysis, taking the sampling method into account, was used to identify risk factors. RESULTS: The sample comprised 49.5% females, the 25- to 34-year-old age group was the largest, and the mean age was 42.7±12.4 years. The prevalence of hypertension was 27.9% [95% CI: 26.3-29.5%], 77.5% of the subjects were unaware of their high blood pressure, and 81.6% had not taken their drugs two weeks before the survey. Prevalence of known hypertension was 6.9%, prevalence of treated hypertension 4.8%, and prevalence of controlled hypertension 1.9%. Age and obesity were significantly associated with hypertension. Department and profession were not associated with hypertension. CONCLUSION: This study showed a high prevalence of hypertension in the general population in Benin. Better management of this risk factor will contribute to reducing morbidity and mortality due to cardiovascular diseases.
Published: 2012

34. Predictors of early cessation of dairy farming in the French Doubs province: 12-year follow-up

Author: Jean-Jacques Laplante, Jean-Charles Dalphin, Elisabeth Monnet, Isabelle Thaon, Ibrahim Njoya Mounchetrou, Public Health, University Hospital, Mutualité sociale agricole de Franche-Comté, Mutualité sociale agricole, Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)
Subjects: Male, Veterinary medicine, MESH: Asthma, MESH: Occupational Health, MESH : Aged, MESH: Retirement, MESH : Agriculture, 0302 clinical medicine, Surveys and Questionnaires, Odds Ratio, Retirement, education.field_of_study, MESH: Middle Aged, Hazard ratio, MESH : Occupational Diseases, 030210 environmental & occupational health, MESH : Occupational Health, MESH : Dairy Products, Occupational Diseases, MESH : Occupational Exposure, MESH: Young Adult, Cohort, MESH: Agriculture, MESH: Occupational Diseases, MESH : Young Adult, MESH : Cohort Studies, 03 medical and health sciences, MESH : Adolescent, MESH : Respiratory Function Tests, Humans, MESH : Middle Aged, MESH : Health Status, education, Aged, Asthma, MESH: Adolescent, MESH: Age Factors, MESH: Humans, Proportional hazards model, MESH: Questionnaires, MESH : Humans, Public Health, Environmental and Occupational Health, MESH: Adult, medicine.disease, 030228 respiratory system, Agriculture, Dairy Products, MESH: Female, [ SDV.MHEP.PSR ] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Demography, Lung Diseases, Time Factors, Health Status, MESH: Respiratory Function Tests, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, MESH: Occupational Exposure, Cohort Studies, MESH: Lung Diseases, Risk Factors, MESH: Risk Factors, MESH : Female, MESH: Cohort Studies, MESH: Health Status, MESH: Aged, 2. Zero hunger, MESH : Lung Diseases, Age Factors, MESH : Questionnaires, Middle Aged, MESH: Confidence Intervals, MESH : Adult, MESH : Risk Factors, Respiratory Function Tests, Predictive factor, MESH : Retirement, Female, France, MESH : Time Factors, Adult, Adolescent, MESH : Male, Population, MESH : Asthma, MESH : Confidence Intervals, Young Adult, Occupational Exposure, Confidence Intervals, medicine, MESH : France, Dairy farming, Occupational Health, business.industry, MESH: Time Factors, MESH: Male, MESH: Odds Ratio, MESH: France, MESH : Odds Ratio, MESH : Age Factors, business, MESH: Dairy Products
Abstract: Background A healthy worker effect due to respiratory disability has been noted in the farming population, but other factors may also interfere. Little has been published about factors influencing the early cessation of work in self-employed dairy farmers. Methods Two hundred and nineteen dairy farmers were included from a cohort constituted in eastern France in 1993–1994 with a 12-year follow-up. Spirometric data, personal, and farm characteristics were registered. Cox models with delayed entry in which age was the time-scale were applied to identify the baseline predictive factors of the early cessation of dairy farming. Results Working in a modern farm was protective against early cessation of dairy farming (hazard ratio: 0.36 [95% CI: 0.16–0.81]), especially in men. Having asthma was a predictive factor of early cessation, especially in women (hazard ratio: 16.12 [95% CI: 3.28–79.12]). Conclusions The most predictive factors of early cessation of dairy farming were health related in women and farm related in men. Am. J. Ind. Med. 55:136–142, 2012. © 2011 Wiley Periodicals, Inc.
Published: 2012

35. Heavy manual work, exposure to vibration and Dupuytren's disease? Results of a surveillance program for musculoskeletal disorders.: Manual work and Dupuytren's disease

Author: Descatha, Alexis, Bodin, Julie, Ha, Catherine, Goubault, Pierre, Lebreton, Marine, Chastang, Jean François, Imbernon, Ellen, Leclerc, Annette, Goldberg, Marcel, Roquelaure, Yves, Service de la Santé au Travail [Poincaré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Raymond Poincaré [AP-HP], Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Laboratoire d'Ergonomie et d'Épidémiologie en Santé au Travail (LEEST), Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Institut de Veille Sanitaire (INVS), Département santé travail (DST-InVS), Institut de Veille Sanitaire (INVS), and Supported by the French Institute for Public Health Surveillance, Saint-Maurice, France (Grant 9/25/2002-5 'réseau expérimental de surveillance des troubles musculo-squelettiques') and the French National Research Agency (ANR-grant SEST-06-36).
Subjects: MESH: Occupational Diseases, Adult, Male, MESH: Dupuytren Contracture, Work, MESH: Logistic Models, Vibration, MESH: Occupational Exposure, Article, MESH: Population Surveillance, MESH: Cross-Sectional Studies, MESH: Risk Factors, Risk Factors, Occupational Exposure, Surveys and Questionnaires, Prevalence, Humans, occupational factor, Occupations, MESH: Prevalence, MESH: Vibration, MESH: Occupations, MESH: Humans, MESH: Middle Aged, MESH: Questionnaires, MESH: Work, MESH: Adult, Middle Aged, vibration exposure, MESH: Male, MESH: France, Dupuytren Contracture, Occupational Diseases, Cross-Sectional Studies, Logistic Models, Population Surveillance, observational study, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, manual work
Abstract: International audience; INTRODUCTION: This study aimed to determine the prevalence of Dupuytren's disease in men and its relationship with work exposure, particularly heavy manual work with and without significant use of vibrating tools, using data from a surveillance program for musculoskeletal disorders. METHOD: This cross-sectional study was conducted in France between 2002 and 2005. Dupuytren's disease was diagnosed clinically by one of 83 occupational physicians. Exposure in relation to work status and occupational risk factors was assessed with a self-administered questionnaire, and categorised according to vibration exposure (defined as use of vibrating tools for ≥2 h/day), heavy manual work without vibration exposure (defined as use of hand tools for ≥2 h/day (use of vibrating tools for ≥2 h/day excluded) and Borg scale ≥15/20) and no such exposure. Bivariate and multivariate associations using logistic models were recorded in men and in those with >10 years in the same job. RESULTS: Of 2161 men, 1.3% (n=27) had Dupuytren's disease (mean age 47.1±6.7 years). Heavy manual work without vibration exposure was significantly associated with the condition (adjusted OR (aOR) 3.9; 95% CI 1.3 to 11.5) adjusted on age and diabetes), as was use of vibrating tools (aOR 5.1; 2.1 to 12.2). These associations remained significant among subjects with >10 years in the same job, with increases in aOR of 6.1 (1.5 to 25.0) and 10.7 (3.4 to 34.6), respectively. CONCLUSION: Despite the limited number of cases, occupational exposure, including both vibration exposure and heavy manual work without significant vibration exposure, was associated with Dupuytren's disease.
Published: 2012

36. Knowledge of stroke among an urban population in Cotonou (Benin)

Author: Hugues Chabriat, Pierre-Marie Preux, Marie-Joëlle Cossi, Claire Gobron, Dismand Houinato, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Service de neurologie [Univ. Paris VII], Université Paris Diderot - Paris 7 (UPD7)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de physiologie et explorations fonctionnelles multidisciplinaires, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Neuroépidémiologie Tropicale et Comparée (NETEC), Université de Limoges (UNILIM)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Unité d'Enseignement et de Recherche de Neurologie (UER neurologie FSS), University of Abomey Calavi (UAC), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7), Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Université de Limoges (UNILIM), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)
Subjects: Male, Health Knowledge, Attitudes, Practice, Multivariate analysis, Epidemiology, Cross-sectional study, MESH: Health Knowledge, Attitudes, Practice, MESH: Comorbidity, Comorbidity, MESH: Hypertension, 0302 clinical medicine, MESH: Aged, 80 and over, Risk Factors, MESH: Risk Factors, Surveys and Questionnaires, Medicine, Benin, MESH: Obesity, 030212 general & internal medicine, Young adult, Stroke, Aged, 80 and over, MESH: Aged, education.field_of_study, MESH: Middle Aged, Traditional medicine, Smoking, 1. No poverty, Middle Aged, MESH: Young Adult, Population Surveillance, Hypertension, Female, Adult, MESH: Smoking, MESH: Diabetes Mellitus, Adolescent, Population, MEDLINE, MESH: Stroke, MESH: Multivariate Analysis, MESH: Population Surveillance, 03 medical and health sciences, Young Adult, Sex Factors, MESH: Benin, MESH: Cross-Sectional Studies, MESH: Sex Factors, Diabetes mellitus, Environmental health, parasitic diseases, Diabetes Mellitus, Humans, Obesity, education, Aged, MESH: Adolescent, MESH: Humans, business.industry, MESH: Questionnaires, MESH: Adult, medicine.disease, MESH: Male, Cross-Sectional Studies, Multivariate Analysis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), business, MESH: Female, 030217 neurology & neurosurgery
Abstract: Background: Studies on the knowledge of stroke, its related risk factors and warning symptoms in the populations of Sub-Saharan Africa are scarce. No study has been performed in Benin until now. Methods: A door-to-door survey was performed in two districts of Cotonou with a broad socioeconomic range. 15,155 individuals aged ≥15 years were interviewed using a semi-structured questionnaire adapted from previous reports. Results: 15,155 individuals consented to participate in the survey. 14.1% correctly identified the brain as the affected organ in stroke. The most commonly identified risk factor was hypertension (34.5%). The most often cited warning signs of stroke were paralysis and hemiplegia (34.4%). Relatives were the major source of information about stroke (25.1%). In multivariate analysis, age, education level, occupation, self-reported risk factors of stroke, overweight and obesity were associated with at least one correct response to the questionnaire about stroke risk factors or symptoms. Conclusion: The awareness of stroke, and its risk factors and symptoms is low in Cotonou. The results suggest that specific education programs may improve people’s knowledge of stroke and their awareness of related risk factors in Sub-Saharan African countries.
Published: 2012

37. Choice of rating method for assessing occupational asbestos exposure: study for compensation purposes in France

Author: Gramond, Céline, Rolland, Patrick, Lacourt, Aude, Ducamp, Stéphane, Chamming'S, Soizick, Creau, Yvon, Héry, Michel, Laureillard, Jacques, Mohammed-Brahim, Brahim, Orlowski, Ewa, Paris, Christophe, Pairon, Jean-Claude, Goldberg, Marcel, Brochard, Patrick, Gramond, Céline, Epidémiologie et Biostatistique [Bordeaux], Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Université Bordeaux Segalen - Bordeaux 2, Département santé travail (DST-InVS), Institut de Veille Sanitaire (INVS), Institut Interuniversitaire de Médecine du Travail de Paris Ile de France, Laboratoire de chimie, Caisse Régionale d'Assurance Maladie Normandie, Institut national de recherche et de sécurité (Vandoeuvre lès Nancy) (INRS ( Vandoeuvre lès Nancy)), Caisse Régionale d'Assurance Maladie Ile de France, Association de Médecine et de Santé au travail, Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service de médecine du travail (LSTE), CHU Bordeaux [Bordeaux], The PNSM is supported by the National Institute for Public Health Surveillance (InVS), the Ministries of Labour and Health, and the Foundation for Medical Research (one-time grant)., and Members of the PNSM Study Group are listed in the acknowledgment section
Subjects: MESH: Occupational Diseases, MESH: Occupations, MESH: Humans, MESH: Mesothelioma, MESH: Probability, MESH: Questionnaires, experts, MESH: Compensation and Redress, occupational exposure, asbestos, MESH: Risk Assessment, MESH: Case-Control Studies, rating method, MESH: Male, MESH: Occupational Exposure, MESH: Reproducibility of Results, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, kappa coefficient, MESH: Asbestos, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Female
Abstract: International audience; BACKGROUND: In the course of setting up the National Mesothelioma Surveillance Program (PNSM), established in France in 1998, the question arose as to the most suitable method of assessing occupational exposure. The aim of this study was to define the most suitable rating method for assessing occupational asbestos exposure in order to assess medico-social care. METHOD: The study included 100 subjects-50 cases of mesothelioma and 50 controls-randomly selected and representing 457 jobs held. Job asbestos exposure was assessed by a six-expert panel using two methods: "by job" rating, where all the jobs in were assessed regardless of the subjects; and "by subject" rating, where all the jobs of a subject were assessed at the same time. Consensus was obtained and subjects' exposure was calculated for each rating. Then, two internal experts assessed job asbestos exposure with the "by subject" rating. Kappa coefficients were used to measure agreement between the ratings. RESULTS: Agreement between "by job" and "by subject" ratings was very good for subject probability of exposure (kappa = 0.84) and cumulative exposure index (kappa = 0.80). Agreement between the six-expert panel and the two internal experts was good for subject exposure (kappa for probability = 0.71; kappa for cumulative exposure index= 0.68). CONCLUSION: This study shows that the two rating systems have good or very good agreement. These results validate the routine use in the PNSM of the "by subject" rating, with the advantage of being convenient and quick to provide feedback on occupational asbestos exposure to mesothelioma cases for compensation.
Published: 2012

38. Stroke: prevalence and disability in Cotonou, Benin

Author: Didier Niama, Marie-Joëlle Cossi, Claire Gobron, Hugues Chabriat, Dismand Houinato, Pierre-Marie Preux, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de physiologie et explorations fonctionnelles multidisciplinaires, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Hôpital Lariboisière, Service de neurologie [Univ. Paris VII], Université Paris Diderot - Paris 7 (UPD7)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Neuroépidémiologie Tropicale et Comparée (NETEC), Université de Limoges (UNILIM)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Unité d'Enseignement et de Recherche de Neurologie (UER neurologie FSS), University of Abomey Calavi (UAC), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Université de Limoges (UNILIM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7), and Université Paris Diderot - Paris 7 (UPD7)-Hôpital Lariboisière-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)
Subjects: Male, Pediatrics, MESH: Urban Health, Activities of daily living, Time Factors, MESH: Chi-Square Distribution, Cross-sectional study, Disability Evaluation, 0302 clinical medicine, MESH: Aged, 80 and over, MESH: Health Surveys, Cost of Illness, Surveys and Questionnaires, Activities of Daily Living, Prevalence, Medicine, Benin, Mass Screening, 030212 general & internal medicine, Young adult, Age of Onset, Stroke, Aged, 80 and over, MESH: Aged, MESH: Middle Aged, 1. No poverty, MESH: Disability Evaluation, Middle Aged, MESH: Cost of Illness, Prognosis, MESH: Recovery of Function, MESH: Predictive Value of Tests, 3. Good health, Neurology, MESH: Young Adult, Female, Cardiology and Cardiovascular Medicine, MESH: Tomography, X-Ray Computed, Adult, medicine.medical_specialty, Adolescent, Stroke prevalence, MESH: Age of Onset, MESH: Prognosis, MESH: Stroke, 03 medical and health sciences, Young Adult, Quality of life (healthcare), MESH: Benin, MESH: Cross-Sectional Studies, Predictive Value of Tests, Environmental health, parasitic diseases, Humans, MESH: Mass Screening, Socioeconomic status, MESH: Prevalence, Aged, MESH: Adolescent, Chi-Square Distribution, MESH: Humans, business.industry, MESH: Questionnaires, MESH: Activities of Daily Living, MESH: Time Factors, Urban Health, MESH: Quality of Life, MESH: Adult, Recovery of Function, medicine.disease, Health Surveys, MESH: Male, Cross-Sectional Studies, Quality of Life, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), Age of onset, business, Tomography, X-Ray Computed, MESH: Female, 030217 neurology & neurosurgery
Abstract: Background: Little is known about the burden of stroke in sub-Saharan Africa that may increase with the ongoing demographic and socioeconomic transition. This study aims to assess the prevalence of stroke, its related disability rate and consequences in the quality of daily life in an urban door- to-door survey in Cotonou, Benin. Methods: A three-phase door-to-door study was performed in two districts of Cotonou with a broad range of socioeconomic income. A population of 15,155 individuals aged ≧15 years was evaluated. The first phase consisted in screening of stroke in the population using the modified WHO questionnaire, the second phase included the medical evaluation of all suspected cases, and in the third phase the diagnosis of stroke was confirmed by CT scan evaluation. Results: Out of 15,155 subjects, 321 cases were identified as possible stroke cases. The diagnosis was confirmed in 70 cases. The crude prevalence of stroke was thus estimated to be 4.6/1,000 (8.7/1,000 and 7.7/1,000 adjusted to the WHO and SEGI World Population). The mean age of the patients at onset was 56 ± 13 years. Sixty percent of stroke survivors had a Rankin score ≧2, and CT scan was found abnormal in 90.0% of them. Conclusion: The stroke prevalence in urban areas of Cotonou is higher than that reported in other sub-Saharan countries, and the majority of stroke survivors present with good functional recovery and without severe disability in their everyday life.
Published: 2012

39. The risk of lung cancer related to dietary intake of flavonoids

Author: Michal Abrahamowicz, Jack Siemiatycki, Javier Pintos, Anita Koushik, Marie-Élise Parent, Adonia Naidu, Krista Yorita Christensen, Hospital Research Centre, Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), Department of Social and Preventive Medicine, Department of Epidemiology, Biostatistics and Occupational Health [Montréal], McGill University = Université McGill [Montréal, Canada], and Université de Montréal. École de santé publique. Département de médecine sociale et préventive
Subjects: Male, Cancer Research, Lung Neoplasms, Flavonoid, Medicine (miscellaneous), Physiology, MESH: Logistic Models, Logistic regression, Anthocyanins, Flavonols, Risk Factors, MESH: Risk Factors, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Surveys and Questionnaires, Odds Ratio, Food science, chemistry.chemical_classification, MESH: Aged, education.field_of_study, Nutrition and Dietetics, MESH: Middle Aged, Smoking, food and beverages, MESH: Life Style, Case-control study, MESH: Carcinoma, Squamous Cell, Middle Aged, MESH: Confidence Intervals, MESH: Case-Control Studies, MESH: Flavanones, Oncology, Epidemiological, Flavanones, Carcinoma, Squamous Cell, Female, Lung cancer, Adult, Canada, MESH: Smoking, Population, Adenocarcinoma, MESH: Multivariate Analysis, MESH: Anthocyanins, MESH: Diet, MESH: Canada, medicine, Confidence Intervals, Humans, education, Life Style, Aged, Flavonoids, MESH: Humans, business.industry, MESH: Flavones, MESH: Questionnaires, MESH: Adenocarcinoma, MESH: Adult, Odds ratio, medicine.disease, Flavones, Confidence interval, MESH: Male, MESH: Odds Ratio, Diet, MESH: Lung Neoplasms, Logistic Models, chemistry, Case-Control Studies, Multivariate Analysis, business, MESH: Flavonoids, MESH: Female
Abstract: International audience; It has been hypothesized that flavonoids in foods and beverages may reduce cancer risk through antioxidation, inhibition of inflammation, and other antimutagenic and antiproliferative properties. We examined associations between intake of 5 flavonoid subclasses (anthocyanidins, flavan-3-ols, flavones, flavonols, and flavanones) and lung cancer risk in a population-based case-control study in Montreal, Canada (1061 cases and 1425 controls). Flavonoid intake was estimated from a food frequency questionnaire that assessed diet 2 yr prior to diagnosis (cases) or interview (controls). Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. Overall, total flavonoid intake was not associated with lung cancer risk, the effect being similar regardless of sex and smoking level. However, low flavonoid intake from food, but not from beverages, was associated with an increased risk. The adjusted ORs (95% CIs) comparing the highest vs. the lowest quartiles of intake were 0.63 (0.47-0.85) for total flavonoids, 0.82 (0.61-1.11) for anthocyanidins, 0.67 (0.50-0.90) for flavan-3-ols, 0.68 (0.50-0.93) for flavones, 0.62 (0.45-0.84) for flavonols, and 0.70 (0.53-0.94) for flavanones. An inverse association with total flavone and flavanone intake was observed for squamous cell carcinoma but not adenocarcinoma. In conclusion, low flavonoid intake from food may increase lung cancer risk.
Published: 2012

40. Effect of intensity and type of physical activity on mortality: results from the Whitehall II cohort study

Author: Eric J. Brunner, Archana Singh-Manoux, Mika Kivimäki, Séverine Sabia, Aline Dugravot, Martin J. Shipley, Schmaus, Annie, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Epidemiology and Public Health, University College of London [London] (UCL), Centre de Gérontologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Funding sources: AS-M is supported by a 'European Young Investigator Award' from the European Science Foundation, MK is supported by the BUPA Foundation, UK and the Academy of Finland, and MJS is supported by the British Heart Foundation. The Whitehall II study has been supported by grants from the British Medical Research Council (MRC), the British Heart Foundation, the British Health and Safety Executive, the British Department of Health, the National Heart, Lung, and Blood Institute (R01HL036310), the National Institute on Aging (R01AG013196 and R01AG034454)., and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)
Subjects: Adult, Male, 030204 cardiovascular system & hematology, Lower risk, Cohort Studies, MESH: Cause of Death, 03 medical and health sciences, 0302 clinical medicine, Cause of Death, Surveys and Questionnaires, London, Humans, Medicine, Longitudinal Studies, Prospective Studies, 030212 general & internal medicine, Mortality, Exercise physiology, Prospective cohort study, MESH: Longitudinal Studies, Exercise, MESH: Cohort Studies, Aged, Cause of death, MESH: Aged, MESH: Middle Aged, MESH: Humans, MESH: Mortality, business.industry, MESH: Questionnaires, Hazard ratio, Public Health, Environmental and Occupational Health, MESH: Adult, MESH: Follow-Up Studies, Middle Aged, MESH: London, Confidence interval, MESH: Male, MESH: Prospective Studies, Intensity (physics), [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Exercise, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Follow-Up Studies, Demography, Cohort study
Abstract: Objectives. We examined the association of intensity and type of physical activity with mortality. Methods. We assessed the duration of physical activity by intensity level and type in 7456 men and women from the Whitehall II Study by questionnaire in 1997–1999 (mean ±SD age = 55.9 ±6.0 years) and 5 years later. All-cause mortality was assessed until April 2009. Results. A total of 317 participants died during the mean follow-up of 9.6 years (SD = 2.7). Reporting at least 1 hour per week of moderate activity was associated with a 33% (95% confidence interval [CI] = 14%, 45%) lower risk of mortality compared with less than 1 hour. For all physical activity types examined, except housework, a duration of physical activity greater than 0 (≥ 3.5 hours for walking) was associated with lower mortality in age-adjusted analyses, but only the associations with sports (hazard ratio [HR] = 0.71; 95% CI = 0.56, 0.91) and do-it-yourself activity (HR = 0.68; 95% CI = 0.53, 0.98) remained in fully adjusted analyses. Conclusions. It is important to consider both intensity and type of physical activity when examining associations with mortality.
Published: 2012

41. Population-based study of epilepsy in Cambodia associated factors, measures of impact, stigma, quality of life, knowledge-attitude-practice, and treatment gap

Author: Devender Bhalla, Robert Sebbag, Daniel Gérard, Michel Dumas, Samleng Chan, Chamroeun Hun, Mey Vannareth, Pierre Huc, Kimly Chea, Michel Druet-Cabanac, Pierre-Marie Preux, Sophal Oum, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Sanofi-Aventis R&D, SANOFI Recherche, Service de Santé au Travail [CHU Limoges], CHU Limoges, Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Laboratoire de Biostatistique et d'Informatique Médicale, and Université de Limoges (UNILIM)
Subjects: Male, Health Knowledge, Attitudes, Practice, Non-Clinical Medicine, Epidemiology, MESH: Health Knowledge, Attitudes, Practice, Life Course Epidemiology, lcsh:Medicine, Epilepsy, 0302 clinical medicine, Quality of life, Surveys and Questionnaires, Medicine, Clinical Epidemiology, 030212 general & internal medicine, Family history, lcsh:Science, education.field_of_study, Multidisciplinary, Neurology, MESH: Epilepsy, Female, Cambodia, Research Article, medicine.medical_specialty, Clinical Research Design, Population, MESH: Stereotyping, Stigma (botany), 03 medical and health sciences, Humans, Risk factor, education, Psychiatry, Biology, Lifecourse Epidemiology, Stereotyping, Health Care Policy, MESH: Humans, Population Biology, business.industry, MESH: Cambodia, MESH: Questionnaires, lcsh:R, MESH: Quality of Life, Odds ratio, medicine.disease, MESH: Male, Social Epidemiology, Attributable risk, Quality of Life, lcsh:Q, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, 030217 neurology & neurosurgery, Demography
Abstract: International audience; PURPOSE: Identify epilepsy-associated factors and calculate measures of impact, stigma, quality of life (QOL), knowledge-attitude-practice (KAP) and treatment gap in Prey Veng, Cambodia. METHODS: This first Cambodian population-based case-control study had 96 epileptologist-confirmed epilepsy cases and 192 randomly selected matched healthy controls. Standard questionnaires, which have been used in similar settings, were used for collecting data on various parameters. Univariate and multivariate regression was done to determine odds ratios. Jacoby stigma, 31-item QOL, KAP etc were determined and so were the factors associated with them using STATA software. Treatment gap was measured using direct method. KEY FINDINGS: Multivariate analyses yielded family history of epilepsy, difficult or long delivery, other problems beside seizures (mainly mental retardation, hyperthermia), and eventful pregnancy of the subject's mother as factors associated with epilepsy. There was high frequency of seizure precipitants esp. those related to sleep. Population attributable risk (%) was: family history (15.0), eventful pregnancy of subject's mother (14.5), long/difficult birth (6.5), and other problem beside seizures (20.0). Mean stigma (1.9±1.1, on a scale of 3) was mainly related to treatment efficacy. Mean QOL (5.0±1.4 on a scale of 10) was mainly related to treatment regularity. Cause or risk factor could be determined in 56% of cases. Treatment gap was 65.8%. SIGNIFICANCE: Factors in pre- and perinatal period were found to be most crucial for epilepsy risk in Cambodia which inturn provides major prevention opportunities. A global action plan for treatment, stigma reduction and improvement of QOL should be set-up in this country.
Published: 2012

42. Usefulness of a single-item measure of depression to predict mortality: the GAZEL prospective cohort study.: single-item of depression and mortality

Author: Lefèvre, Thomas, Singh-Manoux, Archana, Stringhini, Silvia, Dugravot, Aline, Lemogne, Cédric, Consoli, Silla, Goldberg, Marcel, Zins, Marie, Nabi, Hermann, Schmaus, Annie, Laboratoire de Traitement de l'Information Medicale (LaTIM), Université européenne de Bretagne - European University of Brittany (UEB)-Université de Brest (UBO)-Télécom Bretagne-Institut Mines-Télécom [Paris] (IMT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Epidemiology and Public Health, University College of London [London] (UCL), Centre de Gérontologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Sainte Perine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Service Universitaire de Psychiatrie de l'Adulte et du sujet âgé, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Emotion, Université Pierre et Marie Curie - Paris 6 (UPMC)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), The GAZEL cohort study was funded by EDF-GDF and INSERM, and received grants from the Cohortes Santé TGIR Program. ASM is supported by a EUYRI award from the European Science Foundation and the National Institute on Aging, NIH (R01AG013196, and R01AG034454).
Subjects: MESH: Psychiatric Status Rating Scales, MESH: Socioeconomic Factors, MESH: Humans, MESH: Middle Aged, MESH: Depression, MESH: Questionnaires, MESH: Health Behavior, MESH: Adult, MESH: Follow-Up Studies, mortality, MESH: Predictive Value of Tests, MESH: Prospective Studies, MESH: Male, MESH: Cause of Death, MESH: Proportional Hazards Models, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Risk Factors, depression, single-item, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Female
Abstract: International audience; BACKGROUND: It remains unknown whether short measures of depression perform as well as long measures in predicting adverse outcomes such as mortality. The present study aims to examine the predictive value of a single-item measure of depression for mortality. METHODS: A total of 14,185 participants of the GAZEL cohort completed the 20-item Center-for-Epidemiologic-Studies-Depression (CES-D) scale in 1996. One of these items (I felt depressed) was used as a single-item measure of depression. All-cause mortality data were available until 30 September 2009, a mean follow-up period of 12.7 years with a total of 650 deaths. RESULTS: In Cox regression model adjusted for baseline socio-demographic characteristics, a one-unit increase in the single-item score (range 0-3) was associated with a 25% higher risk of all-cause mortality (95% CI: 13-37%, P
Published: 2012

43. Heavy manual work, exposure to vibration and Dupuytren's disease? Results of a surveillance program for musculoskeletal disorders

Author: Descatha, Alexis, Bodin, Julie, Ha, Catherine, Goubault, Pierre, Lebreton, Marine, Chastang, Jean François, Imbernon, Ellen, Leclerc, Annette, Goldberg, Marcel, Roquelaure, Yves, Schmaus, Annie, Service de la Santé au Travail [Poincaré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Raymond Poincaré [AP-HP], Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Ergonomie et d'Épidémiologie en Santé au Travail (LEEST), Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Institut de Veille Sanitaire (INVS), Département santé travail (DST-InVS), Institut de Veille Sanitaire (INVS), and Supported by the French Institute for Public Health Surveillance, Saint-Maurice, France (Grant 9/25/2002-5 'réseau expérimental de surveillance des troubles musculo-squelettiques') and the French National Research Agency (ANR-grant SEST-06-36).
Subjects: MESH: Occupational Diseases, MESH: Vibration, MESH: Dupuytren Contracture, MESH: Occupations, MESH: Humans, MESH: Middle Aged, MESH: Questionnaires, MESH: Work, Dupuytren contracture, MESH: Adult, MESH: Logistic Models, vibration exposure, MESH: Male, MESH: Occupational Exposure, MESH: Population Surveillance, MESH: France, MESH: Cross-Sectional Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Risk Factors, observational study, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, occupational factor, manual work, MESH: Prevalence
Abstract: International audience; INTRODUCTION: This study aimed to determine the prevalence of Dupuytren's disease in men and its relationship with work exposure, particularly heavy manual work with and without significant use of vibrating tools, using data from a surveillance program for musculoskeletal disorders. METHOD: This cross-sectional study was conducted in France between 2002 and 2005. Dupuytren's disease was diagnosed clinically by one of 83 occupational physicians. Exposure in relation to work status and occupational risk factors was assessed with a self-administered questionnaire, and categorised according to vibration exposure (defined as use of vibrating tools for ≥2 h/day), heavy manual work without vibration exposure (defined as use of hand tools for ≥2 h/day (use of vibrating tools for ≥2 h/day excluded) and Borg scale ≥15/20) and no such exposure. Bivariate and multivariate associations using logistic models were recorded in men and in those with >10 years in the same job. RESULTS: Of 2161 men, 1.3% (n=27) had Dupuytren's disease (mean age 47.1±6.7 years). Heavy manual work without vibration exposure was significantly associated with the condition (adjusted OR (aOR) 3.9; 95% CI 1.3 to 11.5) adjusted on age and diabetes), as was use of vibrating tools (aOR 5.1; 2.1 to 12.2). These associations remained significant among subjects with >10 years in the same job, with increases in aOR of 6.1 (1.5 to 25.0) and 10.7 (3.4 to 34.6), respectively. CONCLUSION: Despite the limited number of cases, occupational exposure, including both vibration exposure and heavy manual work without significant vibration exposure, was associated with Dupuytren's disease.
Published: 2012

44. Job Strain and Tobacco Smoking: An Individual-Participant Data Meta-Analysis of 166 130 Adults in 15 European Studies

Author: Heikkilä, Katriina, Nyberg, Solja T., Fransson, Eleonor I., Alfredsson, Lars, de Bacquer, Dirk, Bjorner, Jakob B., Bonenfant, Sébastien, Borritz, Marianne, Burr, Hermann, Clays, Els, Casini, Annalisa, Dragano, Nico, Erbel, Raimund, Geuskens, Goedele A., Goldberg, Marcel, Hooftman, Wendela E., Houtman, Irene L., Joensuu, Matti, Jöckel, Karl-Heinz, Kittel, France, Knutsson, Anders, Koskenvuo, Markku, Koskinen, Aki, Kouvonen, Anne, Leineweber, Constanze, Lunau, Thorsten, Madsen, Ida E. H., Hanson, Linda L. Magnusson, Marmot, Michael G., Nielsen, Martin L., Nordin, Maria, Pentti, Jaana, Salo, Paula, Rugulies, Reiner, Steptoe, Andrew, Siegrist, Johannes, Suominen, Sakari, Vahtera, Jussi, Virtanen, Marianna, Väänänen, Ari, Westerholm, Peter, Westerlund, Hugo, Zins, Marie, Theorell, Töres, Hamer, Mark, Ferrie, Jane E., Singh-Manoux, Archana, David Batty, G., Kivimäki, Mika, IPD-Work Consortium, UCL - SSH/IPSY - Psychological Sciences Research Institute, ULB - School of public health, Finnish Institute of Occupational Health, Stress Research Institute, Stockholm University, School of Health Science, Jönköping University [Sweden], Institute of Environmental Medicine, Karolinska Institutet [Stockholm], Centre for Occupational and Environmental Medicine, Stockholm County Council, Department of Public Health, Universiteit Gent = Ghent University [Belgium] (UGENT), National Research Centre for the Working Environment, National Research Centre for the Working Environment (NRCWE), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Federal Institute for Occupational Safety and Health (BAuA), State University of Ghent, School of Public Health, Université libre de Bruxelles (ULB), Institute for Medical Sociology, Medical Faculty, Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], Department of cardiology, Universität Duisburg-Essen [Essen], The Netherlands Organisation for Applied Scientific Research (TNO), Institute for Medical Informatics, Biometry, and Epidemiology, Department of Health Sciences, Mid Sweden University, School of Sociology, Social Policy, & Social Work, Queen's University [Belfast] (QUB), Department of Epidemiology and Public Health, University College of London [London] (UCL), Department of Psychology, Umeå University, Department of Public Health [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Department of Medical Sociology, Medical Faculty, Nordic School of Public Health, University of Turku, Folkhälsan Research Center, The IPD work consortium is supported by the EU New OSH ERA research programme (funded by the Finnish Work Environment Fund, Finland, the SwedishResearch Council for Working Life and Social Research, Sweden, the German Social Accident Insurance, Germany, the Danish Work Environment ResearchFund,Denmark), the Academy of Finland (grant#132944), and the BUPA Foundation (grant 22094477). The HNR was funded by the Heinz Nixdorf Foundation, Germany,German Ministry of Education and Science (BMBF) and the German Research Foundation (DFG). The German Social Accident Insurance (DGUV) supports analyses inthe frame of the OSH ERA project. POLS was funded by the Ministry of Social Affairs and Employment, The Netherlands. The funders had no role in the study design,data collection and analysis, decision to publish, or preparation of the manuscript, SZTAJNBOK, Pascale, Universiteit Gent = Ghent University (UGENT), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Hjelt Institute (-2014), Department of Social Research (2010-2017), Sociology, and Center for Population, Health and Society
Subjects: Male, Longitudinal study, Pulmonology, Cross-sectional study, Epidemiology, OVERTIME, medicine.medical_treatment, Logistic regression, Social and Behavioral Sciences, 0302 clinical medicine, Surveys and Questionnaires, Odds Ratio, Medicine, Psychology, Longitudinal Studies, lcsh:Science, ASSOCIATIONS, Tobacco harm reduction, MESH: Middle Aged, ta3142, MESH: European Continental Ancestry Group, Sciences bio-médicales et agricoles, 030210 environmental & occupational health, MESH: Smoking Cessation, 3. Good health, MESH: Young Adult, Public Health, Behavioral and Social Aspects of Health, education, Psychological Stress, White People, 03 medical and health sciences, MESH: Cross-Sectional Studies, Sciences sociales, WORK STRESS, Humans, PATIENT DATA, Aged, MESH: Adolescent, MESH: Humans, Job strain, MESH: Questionnaires, lcsh:R, MESH: Adult, Odds ratio, FINNISH PUBLIC-SECTOR, BSS - Behavioural and Societal Sciences, Sciences humaines, Cross-Sectional Studies, Organisation, Smoking cessation, lcsh:Q, ADVERSE HEALTH BEHAVIORS, MESH: Female, Medicin och hälsovetenskap, Medizin, lcsh:Medicine, Medical and Health Sciences, Medicine and Health Sciences, 030212 general & internal medicine, Workplace, MESH: Workplace, RISK, MESH: Aged, Multidisciplinary, Smoking, Public Health, Global Health, Social Medicine and Epidemiology, MESH: Stress, Psychological, Middle Aged, 3142 Public health care science, environmental and occupational health, Europe, TRIALS, Mental Health, Female, Healthy Living, Research Article, Adult, MESH: Smoking, MESH: Socioeconomic Factors, Tobacco Control, Adolescent, WH - Work & Health, Clinical Research Design, WHITEHALL-II, Young Adult, Environmental health, Primary Care, business.industry, Smoking Related Disorders, Confidence interval, MESH: Male, MESH: Odds Ratio, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Smoking Cessation, MESH: Europe, Healthy for Life, business, Stress, Psychological
Abstract: Tobacco smoking is a major contributor to the public health burden and healthcare costs worldwide, but the determinants of smoking behaviours are poorly understood. We conducted a large individual-participant meta-analysis to examine the extent to which work-related stress, operationalised as job strain, is associated with tobacco smoking in working adults., Journal Article, Research Support, Non-U.S. Gov't, SCOPUS: ar.j, info:eu-repo/semantics/published
Published: 2012

45. Clinical features and evolution of alveolar echinococcosis in France from 1982 to 2007: results of a survey in 387 patients

Author: Alain Gerard, Jérôme Watelet, Jenny Knapp, Roch Giorgi, Armand Abergel, Bertrand Sudre, Martine Piarroux, Karine Bardonnet, Jérôme Dumortier, Georges Mantion, Jean Beytout, Dominique A. Vuitton, Renaud Piarroux, Solange Bresson-Hadni, Théoriser et modéliser pour aménager (UMR 6049) (ThéMA), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Laboratoire Chrono-environnement - UFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université de la Méditerranée - Aix-Marseille 2, Laboratoire d'Enseignement et de Recherche sur le Traitement de l'Information Médicale (LERTIM), WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, Université de Franche-Comté (UFC), Hôpital Jean Minjoz, Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Institut de Mécanique et d'Ingénierie de Bordeaux (I2M), École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Institut Polytechnique de Bordeaux-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), WHO Collaborating Center on Prevention and Treatment of Human Echinococcosis, SERF Unit, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), HESAM Université (HESAM)-HESAM Université (HESAM)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut National de la Recherche Agronomique (INRA), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Laboratoire Chrono-environnement (UMR 6249) (LCE), Institut National de la Recherche Agronomique (INRA)-Université de Bordeaux (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO), Théoriser et modéliser pour aménager ( ThéMA ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Laboratoire d'Enseignement et de Recherche sur le Traitement de l'Information Médicale ( LERTIM ), Université de Franche-Comté ( UFC ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Institut de Mécanique et d'Ingénierie de Bordeaux ( I2M ), Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique ( CNRS ) -Institut National de la Recherche Agronomique ( INRA ) -Université de Bordeaux ( UB ), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), and Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC )
Subjects: Male, Pediatrics, MESH : Retrospective Studies, MESH : Anthelmintics, MESH : Prospective Studies, MESH : Aged, MESH : Echinococcus multilocularis, Severity of Illness Index, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, 0302 clinical medicine, MESH: Aged, 80 and over, Surveys and Questionnaires, MESH : Female, MESH: Animals, Prospective Studies, MESH: Incidence, Young adult, Prospective cohort study, Aged, 80 and over, Anthelmintics, MESH: Aged, education.field_of_study, MESH : Prognosis, MESH: Middle Aged, biology, Incidence, Hazard ratio, MESH: Echinococcosis, Hepatic, MESH : Questionnaires, Middle Aged, MESH : Adult, Prognosis, Echinococcosis, MESH : Incidence, 3. Good health, MESH: Anthelmintics, MESH : Benzimidazoles, MESH: Young Adult, 030211 gastroenterology & hepatology, Female, MESH : Severity of Illness Index, France, Adult, medicine.medical_specialty, Echinococcosis, Hepatic, MESH: Liver Transplantation, Adolescent, MESH : Male, 030231 tropical medicine, Population, MESH : Young Adult, [SDV.CAN]Life Sciences [q-bio]/Cancer, Echinococcus multilocularis, MESH: Prognosis, 03 medical and health sciences, Young Adult, MESH : Adolescent, MESH: Severity of Illness Index, medicine, Animals, Humans, MESH : Middle Aged, education, MESH : France, MESH : Aged, 80 and over, Aged, Retrospective Studies, MESH: Adolescent, MESH: Echinococcus multilocularis, MESH: Humans, Hepatology, business.industry, MESH: Questionnaires, MESH : Humans, Retrospective cohort study, MESH: Adult, MESH: Retrospective Studies, biology.organism_classification, medicine.disease, MESH: Male, MESH: Prospective Studies, Surgery, Liver Transplantation, MESH: France, Benzimidazoles, MESH : Animals, MESH : Liver Transplantation, business, MESH : Echinococcosis, Hepatic, MESH: Benzimidazoles, MESH: Female, Rare disease
Abstract: International audience; BACKGROUND & AIMS: Alveolar echinococcosis (AE) is a rare disease in humans, caused by the larval stage of the fox tapeworm Echinococcus multilocularis. METHODS: We present here 387 detailed AE cases diagnosed in France from 1982 to 2007 actively identified by a retrospective survey performed in 1997-1998 and prospectively thereafter. RESULTS: Male:female ratio was 1.03 and mean age 57.8 years at time of diagnosis. Among the 362 complete files (including 347 non dead-out and 15 dead-out lesions), 73% of the patients were symptomatic at first admittance. Among them, 83% presented with clinical patterns evocative either of a digestive or a hepatic disorder. Other symptomatic patients presented with erratic clinical pictures, generally due to metastasis or extra-hepatic location of the parasite. Except for a few patients with particularly severe AE who died shortly after the diagnosis, most patients were treated using benzimidazoles. Their mortality tends to merge with that of the general French population, matched by sex, age, and calendar year. This study also highlights an unexpectedly high frequency of blood-tied family cases (13% of patients submitted to a specific questionnaire). CONCLUSIONS: Even though the broad set of clinical features provoked by E. multilocularis makes AE a potential diagnostic trap for many physicians, our study revealed an improvement of its prognosis. However, as shown by our findings about the frequency of family cases, there is still a need for studies aimed at better describing this uncommon parasitic disease.
Published: 2011

46. Maternal weight change before pregnancy in relation to birthweight and risks of adverse pregnancy outcomes

Author: Diouf, Ibrahima, Charles, Marie Aline, Thiebaugeorges, Olivier, Forhan, Anne, Kaminski, Monique, Heude, Barbara, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Foetopathologie et placentologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Recherche Epidémiologique en Santé Périnatale et Santé des Femmes et des Enfants (UMR_S 953), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), The EDEN Study is funded by grants from the Foundation for Medical Research, the French Ministry of Research: the Institut Fédératif de Recherche program, the Institut National de la Santé et de la Recherche Médicale Human Nutrition National Research Program, and the Diabetes National Research Program (via a collaboration with the French Association for Diabetes Research), the French Ministry of Health Perinatality Program, the French Agency for Environment Security, the French National Institute for Population Health Surveillance, the Paris-Sud University, the French National Institute for Health Education, Nestlé, the National Education Health Insurance (MGEN), the French Speaking Association for the Study of Diabetes and Metabolism, the National Agency for Research (nonthematic program), and the National Institute for Research in Public Health (TGIR health cohort 2008 program)., the EDEN Mother-child cohort study group, and De Lauzon-Guillain, Blandine
Subjects: MESH: Socioeconomic Factors, adverse pregnancy outcomes, MESH: Humans, MESH: Questionnaires, Weight change, MESH: Adult, MESH: Hospitals, Teaching, MESH: Pregnancy Outcome, MESH: Mothers, MESH: Body Mass Index, MESH: France, MESH: Pregnancy, birthweight, MESH: Pregnancy Complications, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Gestational Age, MESH: Pregnancy Trimester, Second, MESH: Pregnancy Trimester, Third, MESH: Weight Gain, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Birth Weight, MESH: Cohort Studies, MESH: Female, MESH: Fetal Development
Abstract: International audience; Maternal weight change before pregnancy can be considered as an indicator of maternal energy balance and nutritional status before conception, and may be involved in early life programming. We aimed to investigate the association of maternal Weight Change Before Pregnancy (WCBP) with fetal growth and adverse pregnancy outcomes. Data are from the French EDEN mother-child cohort where 1,756 mother-child pairs had information on mother's weight at 20 years, weight just before pregnancy, fetal anthropometry at second and third trimesters, infant's birthweight and pregnancy complications. The average annual WCBP between 20 years and start of pregnancy (in kg/year) was categorized as: "Weight Loss" (n = 320), "Moderate weight gain" (n = 721) and "High weight gain" (n = 715). The associations of WCBP with fetal and newborn characteristics and with adverse pregnancy outcomes were analyzed, adjusting for maternal and pregnancy characteristics, including the mother's prepregnancy BMI. Interactions between WCBP and prepregnancy BMI were tested. Birthweight and estimated fetal weight in the third trimester increased significantly with increasing WCBP in mothers with BMI
Published: 2011

47. Formative evaluation to improve prevention of sudden infant death syndrome (SIDS): a prospective study

Author: Amélie Ryckewaert, D'Halluin, Michel, Roussey, Bernard, Branger, Anne, Venisse, Patrick, Pladys, Service de Pédiatrie, and Hôpital Pontchaillou-CHU Pontchaillou [Rennes]
Subjects: Adult, Health Knowledge, Attitudes, Practice, MESH: Socioeconomic Factors, MESH: Health Knowledge, Attitudes, Practice, Mothers, MESH: Patient Education as Topic, MESH: Logistic Models, Double-Blind Method, Patient Education as Topic, Surveys and Questionnaires, Humans, MESH: Double-Blind Method, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, MESH: Humans, Prevention, MESH: Questionnaires, MESH: Infant, Newborn, Infant, Newborn, Sudden infant death syndrome (SIDS), Infant, MESH: Adult, MESH: Patient Compliance, MESH: Infant, MESH: Prospective Studies, MESH: Mothers, Logistic Models, MESH: Sudden Infant Death, Socioeconomic Factors, Health education, Patient Compliance, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Prospective studies, MESH: Female, Sudden Infant Death
Abstract: International audience; AIM: To evaluate formative evaluation, a pedagogic method that sensitizes mothers to sudden infant death syndrome (SIDS), as a new way to improve prevention of SIDS. METHODS: Prospective and randomized study. Mothers in a test group (n = 148) received an educative questionnaire about SIDS during maternity stay. Three months later, we evaluated, by a telephonic interview, their scores of knowledge and observance of the recommendations in comparison with a control group (n = 144). RESULTS: Mothers' scores at the educative questionnaire was 5.12 (1.52) [mean(standard deviation)]. The scores performed 3 months later were better in test group for knowledge [7.64 (1.56) vs. 7.16 (1.61), p < 0.01] and for observance [8.28 (1.51) vs. 7.62 (1.72), p < 0.001]. Logistic regression analysis confirmed the benefits in test group regarding knowledge of SIDS risk factors [ORa = 1.69 (1.02-2.77), p < 0.05], of the advice to avoid overheating infants [ORa = 2.50 (1.43-4.38), p < 0.01] and of the risks of bed sharing [ORa = 2.7 (1.6-4.5), p < 0.001]. There was a significant association between non-compliance with the sleeping position recommendation and unemployment (p < 0.01) and absence of postsecondary school education (p < 0.01). CONCLUSION: Formative evaluation using an educative questionnaire could improve maternal awareness on SIDS risk factors and their compliance with recommendations about SIDS prevention.
Published: 2011

48. Maternal weight change before pregnancy in relation to birthweight and risks of adverse pregnancy outcomes

Author: Diouf, Ibrahima, Charles, Marie Aline, Thiebaugeorges, Olivier, Forhan, Anne, Kaminski, Monique, Heude, Barbara, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Service de Foetopathologie et placentologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Recherche Epidémiologique en Santé Périnatale et Santé des Femmes et des Enfants (UMR_S 953), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris-Sud - Paris 11 (UP11), The EDEN Study is funded by grants from the Foundation for Medical Research, the French Ministry of Research: the Institut Fédératif de Recherche program, the Institut National de la Santé et de la Recherche Médicale Human Nutrition National Research Program, and the Diabetes National Research Program (via a collaboration with the French Association for Diabetes Research), the French Ministry of Health Perinatality Program, the French Agency for Environment Security, the French National Institute for Population Health Surveillance, the Paris-Sud University, the French National Institute for Health Education, Nestlé, the National Education Health Insurance (MGEN), the French Speaking Association for the Study of Diabetes and Metabolism, the National Agency for Research (nonthematic program), and the National Institute for Research in Public Health (TGIR health cohort 2008 program)., and the EDEN Mother-child cohort study group
Subjects: MESH: Socioeconomic Factors, adverse pregnancy outcomes, MESH: Humans, MESH: Questionnaires, Weight change, MESH: Adult, MESH: Hospitals, Teaching, MESH: Pregnancy Outcome, MESH: Mothers, MESH: Body Mass Index, MESH: France, MESH: Pregnancy, birthweight, MESH: Pregnancy Complications, MESH: Gestational Age, MESH: Pregnancy Trimester, Second, MESH: Pregnancy Trimester, Third, MESH: Weight Gain, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Birth Weight, MESH: Cohort Studies, MESH: Female, MESH: Fetal Development
Abstract: International audience; Maternal weight change before pregnancy can be considered as an indicator of maternal energy balance and nutritional status before conception, and may be involved in early life programming. We aimed to investigate the association of maternal Weight Change Before Pregnancy (WCBP) with fetal growth and adverse pregnancy outcomes. Data are from the French EDEN mother-child cohort where 1,756 mother-child pairs had information on mother's weight at 20 years, weight just before pregnancy, fetal anthropometry at second and third trimesters, infant's birthweight and pregnancy complications. The average annual WCBP between 20 years and start of pregnancy (in kg/year) was categorized as: "Weight Loss" (n = 320), "Moderate weight gain" (n = 721) and "High weight gain" (n = 715). The associations of WCBP with fetal and newborn characteristics and with adverse pregnancy outcomes were analyzed, adjusting for maternal and pregnancy characteristics, including the mother's prepregnancy BMI. Interactions between WCBP and prepregnancy BMI were tested. Birthweight and estimated fetal weight in the third trimester increased significantly with increasing WCBP in mothers with BMI
Published: 2011

49. Maternal weight change before pregnancy in relation to birthweight and risks of adverse pregnancy outcomes. : Maternal weight change related to birthweight

Author: Monique Kaminski, Olivier Thiebaugeorges, Barbara Heude, Anne Forhan, Marie-Aline Charles, Ibrahima Diouf, Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de Foetopathologie et placentologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Recherche Epidémiologique en Santé Périnatale et Santé des Femmes et des Enfants ( UMR_S 953 ), Université Paris-Sud - Paris 11 ( UP11 ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), The EDEN Study is funded by grants from the Foundation for Medical Research, the French Ministry of Research: the Institut Fédératif de Recherche program, the Institut National de la Santé et de la Recherche Médicale Human Nutrition National Research Program, and the Diabetes National Research Program (via a collaboration with the French Association for Diabetes Research), the French Ministry of Health Perinatality Program, the French Agency for Environment Security, the French National Institute for Population Health Surveillance, the Paris-Sud University, the French National Institute for Health Education, Nestlé, the National Education Health Insurance (MGEN), the French Speaking Association for the Study of Diabetes and Metabolism, the National Agency for Research (nonthematic program), and the National Institute for Research in Public Health (TGIR health cohort 2008 program)., the EDEN Mother-child cohort study group, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Recherche Epidémiologique en Santé Périnatale et Santé des Femmes et des Enfants (UMR_S 953), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris-Sud - Paris 11 (UP11)
Subjects: adverse pregnancy outcomes, Epidemiology, MESH : Pregnancy Trimester, Third, MESH : Pregnancy Trimester, Second, Weight Gain, Body Mass Index, Cohort Studies, Fetal Development, 0302 clinical medicine, MESH: Pregnancy, Weight loss, Pregnancy, MESH: Gestational Age, Surveys and Questionnaires, MESH : Socioeconomic Factors, Birth Weight, MESH : Female, 030212 general & internal medicine, MESH: Cohort Studies, 2. Zero hunger, MESH : Pregnancy Outcome, Obstetrics, Weight change, Pregnancy Outcome, Gestational age, MESH : Questionnaires, MESH : Weight Gain, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH : Adult, MESH: Mothers, 3. Good health, Gestational diabetes, birthweight, MESH: Pregnancy Complications, Pregnancy Trimester, Second, MESH : Mothers, MESH: Pregnancy Trimester, Second, MESH: Pregnancy Trimester, Third, MESH: Weight Gain, Female, France, medicine.symptom, MESH: Fetal Development, Adult, medicine.medical_specialty, MESH: Socioeconomic Factors, Birth weight, Pregnancy Trimester, Third, Mothers, MESH : Cohort Studies, 030209 endocrinology & metabolism, Gestational Age, MESH : Hospitals, Teaching, MESH : Pregnancy Complications, Article, MESH: Body Mass Index, 03 medical and health sciences, medicine, Humans, MESH: Birth Weight, Hospitals, Teaching, MESH : France, MESH: Humans, business.industry, MESH: Questionnaires, MESH : Humans, MESH: Adult, MESH : Birth Weight, MESH: Hospitals, Teaching, medicine.disease, MESH: Pregnancy Outcome, MESH: France, Pregnancy Complications, MESH : Pregnancy, MESH : Body Mass Index, Socioeconomic Factors, MESH : Fetal Development, Small for gestational age, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Weight gain, MESH: Female, MESH : Gestational Age
Abstract: International audience; Maternal weight change before pregnancy can be considered as an indicator of maternal energy balance and nutritional status before conception, and may be involved in early life programming. We aimed to investigate the association of maternal Weight Change Before Pregnancy (WCBP) with fetal growth and adverse pregnancy outcomes. Data are from the French EDEN mother-child cohort where 1,756 mother-child pairs had information on mother's weight at 20 years, weight just before pregnancy, fetal anthropometry at second and third trimesters, infant's birthweight and pregnancy complications. The average annual WCBP between 20 years and start of pregnancy (in kg/year) was categorized as: "Weight Loss" (n = 320), "Moderate weight gain" (n = 721) and "High weight gain" (n = 715). The associations of WCBP with fetal and newborn characteristics and with adverse pregnancy outcomes were analyzed, adjusting for maternal and pregnancy characteristics, including the mother's prepregnancy BMI. Interactions between WCBP and prepregnancy BMI were tested. Birthweight and estimated fetal weight in the third trimester increased significantly with increasing WCBP in mothers with BMI
Published: 2011

50. Analgesics during pregnancy and undescended testis

Author: Bernard Jégou, Lise Giorgis-Allemand, Sylvaine Cordier, Rémy Slama, Claire Philippat, Cécile Chevrier, Marie-Aline Charles, Université Grenoble Alpes - UFR Pharmacie (UGA UFRP), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Epidémiologie pronostique des cancers et affections graves, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), équipe 12 (Epidémiologie Environnementale appliquée à la Reproduction et la Santé Respiratoire), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, medicine.medical_specialty, MESH: Analgesics, Epidemiology, MESH: Logistic Models, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, MESH: Pregnancy, MESH: Cryptorchidism, Pregnancy, Surveys and Questionnaires, Cryptorchidism, Odds Ratio, medicine, Humans, Longitudinal Studies, MESH: Longitudinal Studies, MESH: Cohort Studies, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Analgesics, 0303 health sciences, 030219 obstetrics & reproductive medicine, MESH: Humans, Obstetrics, business.industry, MESH: Questionnaires, MESH: Infant, Newborn, Infant, Newborn, medicine.disease, MESH: Male, MESH: Odds Ratio, Logistic Models, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract: International audience
Published: 2011

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