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5 results on '"M. Leibovitz"'

1. Extensive deletion of immunoglobulin heavy chain constant region genes in the absence of recurrent infections: when is IgG subclass deficiency clinically relevant?

Author

M. Leibovitz, Marzia Duse, Andrea Bottaro, A.O. Carbonara, C. Boccazzi, Alberto Albertini, Antonella Meini, U. Cariota, Alessandro Plebani, R. Brusco, L. Ruggeri, Alberto G. Ugazio, and A. Negrini

Subjects
Male, blood/genetics/immunology, IgG subclass deficiency, Immunoglobulin E, Subclass, immunology, Gene duplication, IGHC, Immunology and Allergy, immunoglobulin heavy chain constant region, IgG deficiency, genetics, Child, Southern, genetics/physiology, Respiratory Tract Infections, In Situ Hybridization, Gel, blood/genetics, Immunity, Cellular, biology, Genes, Immunoglobulin, Blotting, Toxoid, IgA Deficiency, Isotype, Electrophoresis, Gel, Pulsed-Field, Pedigree, Blotting, Southern, classification, Female, Antibody, Immunoglobulin Constant Regions, Immunoglobulin Heavy Chains, Electrophoresis, Adolescent, Pathology and Forensic Medicine, Pulsed-Field, Antigen, Immunoglobulin, Humans, immunoglobulin gene deletion, Chromosome Aberrations, Immunity, Virology, Antibody Formation, Gene Deletion, Genes, IgG Deficiency, Cellular, Immunoglobulin G, Immunology, biology.protein, Immunoglobulin heavy chain
Abstract

This report describes two children with undetectable serum levels of IgA1, IgG2, IgG4, and IgE due to a homozygous deletion encompassing the A1-E genes. The father is a heterozygous carrier of the same deletion and the mother a heterozygous compound carrying the deletion on one chromosome and duplication on the other. In both children, serum IgG, IgG1, and IgG3 were higher than in normal children and IgG antibody response to tetanus toxoid and polysaccharide antigens was normal with increased IgG1 and IgG3 response compared to controls. The latter can be interpreted as a compensatory mechanism for the subclass deficit and may explain the lack of significant infections in both children. The importance of distinguishing IgG subclass deficiency due to gene deletion from that due to immunoregulatory dysfunction is discussed.

Published
1993

2. Simultaneous influenza and pneumococcal vaccination in elderly individuals.

Author

Grilli G, Fuiano L, Biasio LR, Pregliasco F, Plebani A, Leibovitz M, Ugazio AG, Vacca F, and Profeta ML

Subjects
Adult, Aged, Aged, 80 and over, Antibodies, Bacterial blood, Antibodies, Viral blood, Female, Humans, Male, Middle Aged, Vaccination, Bacterial Vaccines administration & dosage, Influenza A virus immunology, Influenza B virus immunology, Influenza Vaccines administration & dosage, Streptococcus pneumoniae immunology
Abstract

The study was performed to evaluate the effects of influenza and pneumococcal vaccines administered alone or in combination. 124 elderly subjects living in community were vaccinated either with influenza split vaccine or with pneumococcal 23-valent or with both vaccines at the same time in different sites. Sera were tested for hemoagglutination inhibiting antibodies for influenza and for antibodies against 23-valent vaccine for streptococcus pneumoniae. No side effects were observed in the vaccinated population. Serological results indicated that influenza vaccine increased significantly antibody levels. No difference was observed between the group which received influenza vaccine alone and that which received influenza and pneumococcal vaccines associated, considering either G.M.T or the percentages of protected individuals or the percentages of subjects who seroconverted. When pneumococcal vaccine was administered at the same time with influenza vaccine, there was a not statistically significant reduction in both mean antibody concentration and mean fold increase. It is concluded that the simultaneous administration of influenza and pneumococcal vaccines to elderly individuals, including subjects at risk, is safe, effective and economically advantageous.

Published
1997
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3. Extensive deletion of immunoglobulin heavy chain constant region genes in the absence of recurrent infections: when is IgG subclass deficiency clinically relevant?

Author

Plebani A, Ugazio AG, Meini A, Ruggeri L, Negrini A, Albertini A, Leibovitz M, Duse M, Bottaro A, and Brusco R

Subjects
Adolescent, Antibody Formation, Blotting, Southern, Child, Chromosome Aberrations genetics, Electrophoresis, Gel, Pulsed-Field, Female, Genes, Immunoglobulin genetics, Humans, IgA Deficiency genetics, IgG Deficiency genetics, Immunity, Cellular, In Situ Hybridization, Male, Pedigree, Gene Deletion, Genes, Immunoglobulin physiology, IgA Deficiency blood, IgA Deficiency immunology, IgG Deficiency blood, Immunoglobulin Constant Regions genetics, Immunoglobulin G classification, Immunoglobulin Heavy Chains genetics, Respiratory Tract Infections immunology
Abstract

This report describes two children with undetectable serum levels of IgA1, IgG2, IgG4, and IgE due to a homozygous deletion encompassing the A1-E genes. The father is a heterozygous carrier of the same deletion and the mother a heterozygous compound carrying the deletion on one chromosome and duplication on the other. In both children, serum IgG, IgG1, and IgG3 were higher than in normal children and IgG antibody response to tetanus toxoid and polysaccharide antigens was normal with increased IgG1 and IgG3 response compared to controls. The latter can be interpreted as a compensatory mechanism for the subclass deficit and may explain the lack of significant infections in both children. The importance of distinguishing IgG subclass deficiency due to gene deletion from that due to immunoregulatory dysfunction is discussed.

Published
1993
Full Text
View/download PDF

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