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ResumenEl trasplante de órganos sólidos se ha incorporado al tratamiento de pacientes portadores de una gran variedad de condiciones clínicas. La falta de una adecuada pesquisa de donantes así como su inadecuado manejo médico son factores relevantes para la ocurrencia de la actual gran carencia de órganos sólidos disponibles para ser trasplantados en nuestro País. En este artículo se presenta una revisión acotada de los términos usualmente empleados y luego se refiere primordialmente a los donantes fallecidos en muerte encefálica (DFME). Se hace énfasis en las ultimas cifras nacionales, las formas con las que contamos para poder predecir la capacidad generadora de potenciales donantes, cómo y dónde detectarlos, las principales estrategias para aumentar su detección, los aspectos fisiopatológicos subyacentes a esta particular condición. Finalmente se presentan algunas recomendaciones para el adecuado manejo del donante potencial, desde su detección hasta que se convierte en donante efectivo.SummarySolid organ transplantation has been incorporated as a valid treatment option for patients that suffer several conditions. The failure to identify potential cadaveric donors early and their subsequent inadequate treatment are undoubtedly relevant factors that go some way to explain the actual shortage of organs available to be transplanted in Chile. In this article we present a review and explanation of the terminology associated with organ donation before focusing on the legal criteria required for the clinical diagnosis of brain-stem death. We use data from other countries in order to predict how many donors should be available in our country as well as trying to anticipate their diagnoses and where they are usually located. The discussion then moves on to present the current reality in Chile before reviewing some measures that have been found useful in other countries to increase donation rates. Finally we present some suggestions on how the patient should be managed from the moment they are considered as a potential donor until they complete the donation process.

We present the optical transmission spectrum of the hot Jupiter WASP-104b based on one transit observed by the blue and red channels of the DBSP spectrograph at the Palomar 200-inch telescope and 14 transits observed by the MuSCAT2 four-channel imager at the 1.52 m Telescopio Carlos Sanchez. We also analyse 45 additional K2 transits, after correcting for the flux contamination from a companion star. Together with the transit light curves acquired by DBSP and MuSCAT2, we are able to revise the system parameters and orbital ephemeris, confirming that no transit timing variations exist. Our DBSP and MuSCAT2 combined transmission spectrum reveals an enhanced slope at wavelengths shorter than 630 nm and suggests the presence of a cloud deck at longer wavelengths. While the Bayesian spectral retrieval analyses favour a hazy atmosphere, stellar spot contamination cannot be completely ruled out. Further evidence, from transmission spectroscopy and detailed characterisation of the host star's activity, is required to distinguish the physical origin of the enhanced slope., 17 pages, 14 figures, accepted for publication in MNRAS

The in vitro susceptibility of Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium africanum, Mycobacterium avium, Mycobacterium fortuitum, and Mycobacterium chelonae (M. chelonei) to ticarcillin in combination with calvulanic acid (CA) was studied by the agar dilution method. All the M. tuberculosis, M. bovis, and M. africanum strains were inhibited at a ticarcillin concentration of 32 micrograms/ml or lower in combination with 5 micrograms of CA. M. chelonae and M. avium strains proved resistant to more than 128 micrograms of ticarcillin plus 5 micrograms of CA per ml. M. fortuitum strains needed 128 micrograms of ticarcillin plus 5 micrograms of CA to inhibit approximately 30% of the isolates.