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1. Sectoral Futures Are Conditional on Choices of Global and National Scenarios – Australian Marine Examples

Author: Fabio Boschetti, Catherine M. Bulman, Alistair J. Hobday, Elizabeth A. Fulton, Stephanie Contardo, Hector Lozano-Montes, Lucy M. Robinson, Anthony D. M. Smith, Joanna Strzelecki, and E. Ingrid van Putten
Subjects: future studies, global scenarios, blue economy, marine resources, global change, Science, General. Including nature conservation, geographical distribution, QH1-199.5
Abstract: Planning and management require expectations of future system behavior. These expectations can come in the form of predictions, projections, scenarios, narratives, visions and intuitions, at different spatial and temporal scales. While each can provide different insights into a system future, it is not clear how they can be effectively combined into a unified analysis. Here, we propose a general framework to combine conceptual models, numerical projections and scenario narratives, leading to a system view of the functioning of the future Blue Economy sectors as applied to Australian oceans. We start by developing a conceptual model of the sectors directly or indirectly interacting with the Australian oceans and their national and global drivers. We then identify scenarios and projections for each global driver as well as projections of future development for the national drivers and for the Blue Economy sectors. Comparisons of the global scenarios, national projections and sectoral projections suggest that the Australian marine sectors expect to follow a path of growth mostly driven by market forces enabled by government regulations. The analysis of each sector provides information on the extent to which the initial conceptual model can be improved as part of more detailed analysis at a sectoral level. This approach supports sector-based marine planning with a consistent and repeatable framing and can help researchers, managers and stakeholders reach a shared understanding of system interactions and the potential impact of future shocks to national and international drivers.
Published: 2020
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2. Contrasting Futures for Australia’s Fisheries Stocks Under IPCC RCP8.5 Emissions – A Multi-Ecosystem Model Approach

Author: Heidi R. Pethybridge, Elizabeth A. Fulton, Alistair J. Hobday, Julia Blanchard, Catherine M. Bulman, Ian R. Butler, William W. L. Cheung, Leo X. C. Dutra, Rebecca Gorton, Trevor Hutton, Richard Matear, Hector Lozano-Montes, Eva E. Plagányi, Cecilia Villanueva, and Xuebin Zhang
Subjects: forecasting, climate change, model uncertainty, fisheries management, adaptive management, ensemble modeling, Science, General. Including nature conservation, geographical distribution, QH1-199.5
Abstract: Climate-driven trends in ocean temperature and primary productivity are projected to differ greatly across the globe, triggering variable levels of concern for marine biota and ecosystems. Quantifying these changes, and the complex ways in which resource-dependent communities will need to respond, is inherently difficult. Existing uncertainty about the structure, function and responses of marine ecosystems, means that a multi-model or ensemble model approach is the most prudent means of assessing the potential ecosystem responses to climate change. In this study, climate-ecological projections of 13 marine ecosystem models for regions around Australia were evaluated. Model types included dynamic food web, spatial whole of ecosystem, intermediate complexity, species distribution, and size spectrum models and were all forced by high-resolution ocean model data. Each Australian region and fishery will face its own challenges in terms of ecosystem shifts and fisheries management responses over the next 30 years. Across regions, demersal systems appear to be more strongly affected by climate change than pelagic systems, with invertebrate species in shallow waters likely to respond first and to a larger degree. With the assistance of qualitative confidence evaluations, the multi-model approach was useful for identifying the likely state of concern for each functional group and thus adaptive management and research priorities. Largest model discrepancies were found between the regional ecosystem models that represent trophic interactions and the species distribution models, with implications for future assessments and adaption planning. Study results highlight that fisheries and their management will need to foster pro-active and flexible adaptation options to make the most of coming opportunities and to minimize risks or negative outcomes.
Published: 2020
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3. Global scaling of the heat transport in fusion plasmas

Author: Sara Moradi, Johan Anderson, Michele Romanelli, Hyun-Tae Kim, JET contributors, X. Litaudon, S. Abduallev, M. Abhangi, P. Abreu, M. Afzal, K. M. Aggarwal, T. Ahlgren, J. H. Ahn, L. Aho-Mantila, N. Aiba, M. Airila, R. Albanese, V. Aldred, D. Alegre, E. Alessi, P. Aleynikov, A. Alfier, A. Alkseev, M. Allinson, B. Alper, E. Alves, G. Ambrosino, R. Ambrosino, L. Amicucci, V. Amosov, E. Andersson Sundén, M. Angelone, M. Anghel, C. Angioni, L. Appel, C. Appelbee, P. Arena, M. Ariola, H. Arnichand, S. Arshad, A. Ash, N. Ashikawa, V. Aslanyan, O. Asunta, F. Auriemma, Y. Austin, L. Avotina, M. D. Axton, C. Ayres, M. Bacharis, A. Baciero, D. Baião, S. Bailey, A. Baker, I. Balboa, M. Balden, N. Balshaw, R. Bament, J. W. Banks, Y. F. Baranov, M. A. Barnard, D. Barnes, M. Barnes, R. Barnsley, A. Baron Wiechec, L. Barrera Orte, M. Baruzzo, V. Basiuk, M. Bassan, R. Bastow, A. Batista, P. Batistoni, R. Baughan, B. Bauvir, L. Baylor, B. Bazylev, J. Beal, P. S. Beaumont, M. Beckers, B. Beckett, A. Becoulet, N. Bekris, M. Beldishevski, K. Bell, F. Belli, M. Bellinger, É. Belonohy, N. Ben Ayed, N. A. Benterman, H. Bergsȧker, J. Bernardo, M. Bernert, M. Berry, L. Bertalot, C. Besliu, M. Beurskens, B. Bieg, J. Bielecki, T. Biewer, M. Bigi, P. Bìlkovà, F. Binda, A. Bisoffi, J. P. S. Bizarro, C. Björkas, J. Blackburn, K. Blackman, T. R. Blackman, P. Blanchard, P. Blatchford, V. Bobkov, A. Boboc, G. Bodnàr, O. Bogar, I. Bolshakova, T. Bolzonella, N. Bonanomi, F. Bonelli, J. Boom, J. Booth, D. Borba, D. Borodin, I. Borodkina, A. Botrugno, C. Bottereau, P. Boulting, C. Bourdelle, M. Bowden, C. Bower, C. Bowman, T. Boyce, C. Boyd, H. J. Boyer, J. M. A. Bradshaw, V. Braic, R. Bravanec, B. Breizman, S. Bremond, P. D. Brennan, S. Breton, A. Brett, S. Brezinsek, M. D. J. Bright, M. Brix, W. Broeckx, M. Brombin, A. Brosawski, D. P. D. Brown, M. Brown, E. Bruno, J. Bucalossi, J. Buch, J. Buchanan, M. A. Buckley, R. Budny, H. Bufferand, M. Bulman, N. Bulmer, P. Bunting, P. Buratti, A. Burckhart, A. Buscarino, A. Busse, N. K. Butler, I. Bykov, J. Byrne, P. Cahyna, G. Calabrò, I. Calvo, Y. Camenen, P. Camp, D. C. Campling, J. Cane, B. Cannas, A. J. Capel, P. J. Card, A. Cardinali, P. Carman, M. Carr, D. Carralero, L. Carraro, B. B. Carvalho, I. Carvalho, P. Carvalho, F. J. Casson, C. Castaldo, N. Catarino, J. Caumont, F. Causa, R. Cavazzana, K. Cave-Ayland, M. Cavinato, M. Cecconello, S. Ceccuzzi, E. Cecil, A. Cenedese, R. Cesario, C. D. Challis, M. Chandler, D. Chandra, C. S. Chang, A. Chankin, I. T. Chapman, S. C. Chapman, M. Chernyshova, G. Chitarin, G. Ciraolo, D. Ciric, J. Citrin, F. Clairet, E. Clark, M. Clark, R. Clarkson, D. Clatworthy, C. Clements, M. Cleverly, J. P. Coad, P. A. Coates, A. Cobalt, V. Coccorese, V. Cocilovo, S. Coda, R. Coelho, J. W. Coenen, I. Coffey, L. Colas, S. Collins, D. Conka, S. Conroy, N. Conway, D. Coombs, D. Cooper, S. R. Cooper, C. Corradino, Y. Corre, G. Corrigan, S. Cortes, D. Coster, A. S. Couchman, M. P. Cox, T. Craciunescu, S. Cramp, R. Craven, F. Crisanti, G. Croci, D. Croft, K. Crombé, R. Crowe, N. Cruz, G. Cseh, A. Cufar, A. Cullen, M. Curuia, A. Czarnecka, H. Dabirikhah, P. Dalgliesh, S. Dalley, J. Dankowski, D. Darrow, O. Davies, W. Davis, C. Day, I. E. Day, M. De Bock, A. de Castro, E. de la Cal, E. de la Luna, G. De Masi, J. L. de Pablos, G. De Temmerman, G. De Tommasi, P. de Vries, K. Deakin, J. Deane, F. Degli Agostini, R. Dejarnac, E. Delabie, N. den Harder, R. O. Dendy, J. Denis, P. Denner, S. Devaux, P. Devynck, F. Di Maio, A. Di Siena, C. Di Troia, P. Dinca, R. Dinca, B. Ding, T. Dittmar, H. Doerk, R. P. Doerner, T. Donné, S. E. Dorling, S. Dormido-Canto, S. Doswon, D. Douai, P. T. Doyle, A. Drenik, P. Drewelow, P. Drews, Ph. Duckworth, R. Dumont, P. Dumortier, D. Dunai, M. Dunne, I. Duran, F. Durodié, P. Dutta, B. P. Duval, R. Dux, K. Dylst, N. Dzysiuk, P. V. Edappala, J. Edmond, A. M. Edwards, J. Edwards, Th. Eich, A. Ekedahl, R. El-Jorf, C. G. Elsmore, M. Enachescu, G. Ericsson, F. Eriksson, J. Eriksson, L. G. Eriksson, B. Esposito, S. Esquembri, H. G. Esser, D. Esteve, B. Evans, G. E. Evans, G. Evison, G. D. Ewart, D. Fagan, M. Faitsch, D. Falie, A. Fanni, A. Fasoli, J. M. Faustin, N. Fawlk, L. Fazendeiro, N. Fedorczak, R. C. Felton, K. Fenton, A. Fernades, H. Fernandes, J. Ferreira, J. A. Fessey, O. Février, O. Ficker, A. Field, S. Fietz, A. Figueiredo, J. Figueiredo, A. Fil, P. Finburg, M. Firdaouss, U. Fischer, L. Fittill, M. Fitzgerald, D. Flammini, J. Flanagan, C. Fleming, K. Flinders, N. Fonnesu, J. M. Fontdecaba, A. Formisano, L. Forsythe, L. Fortuna, E. Fortuna-Zalesna, M. Fortune, S. Foster, T. Franke, T. Franklin, M. Frasca, L. Frassinetti, M. Freisinger, R. Fresa, D. Frigione, V. Fuchs, D. Fuller, S. Futatani, J. Fyvie, K. Gàl, D. Galassi, K. Galazka, J. Galdon-Quiroga, J. Gallagher, D. Gallart, R. Galvão, X. Gao, Y. Gao, J. Garcia, A. Garcia-Carrasco, M. Garca-Munoz, J.-L. Gardarein, L. Garzotti, P. Gaudio, E. Gauthier, D. F. Gear, S. J. Gee, B. Geiger, M. Gelfusa, S. Gerasimov, G. Gervasini, M. Gethins, Z. Ghani, M. Ghate, M. Gherendi, J. C. Giacalone, L. Giacomelli, C. S. Gibson, T. Giegerich, C. Gil, L. Gil, S. Gilligan, D. Gin, E. Giovannozzi, J. B. Girardo, C. Giroud, G. Giruzzi, S. Glöggler, J. Godwin, J. Goff, P. Gohil, V. Goloborod'ko, R. Gomes, B. Goncalves, M. Goniche, M. Goodliffe, A. Goodyear, G. Gorini, M. Gosk, R. Goulding, A. Goussarov, R. Gowland, B. Graham, M. E. Graham, J. P. Graves, N. Grazier, P. Grazier, N. R. Green, H. Greuner, B. Grierson, F. S. Griph, C. Grisolia, D. Grist, M. Groth, R. Grove, C. N. Grundy, J. Grzonka, D. Guard, C. Guérard, C. Guillemaut, R. Guirlet, C. Gurl, H. H. Utoh, L. J. Hackett, S. Hacquin, A. Hagar, R. Hager, A. Hakola, M. Halitovs, S. J. Hall, S. P. Hallworth Cook, C. Hamlyn-Harris, K. Hammond, C. Harrington, J. Harrison, D. Harting, F. Hasenbeck, Y. Hatano, D. R. Hatch, T. D. V. Haupt, J. Hawes, N. C. Hawkes, J. Hawkins, P. Hawkins, P. W. Haydon, N. Hayter, S. Hazel, P. J. L. Heesterman, K. Heinola, C. Hellesen, T. Hellsten, W. Helou, O. N. Hemming, T. C. Hender, M. Henderson, S. S. Henderson, R. Henriques, D. Hepple, G. Hermon, P. Hertout, C. Hidalgo, E. G. Highcock, M. Hill, J. Hillairet, J. Hillesheim, D. Hillis, K. Hizanidis, A. Hjalmarsson, J. Hobirk, E. Hodille, C. H. A. Hogben, G. M. D. Hogeweij, A. Hollingsworth, S. Hollis, D. A. Homfray, J. Horàcek, G. Hornung, A. R. Horton, L. D. Horton, L. Horvath, S. P. Hotchin, M. R. Hough, P. J. Howarth, A. Hubbard, A. Huber, V. Huber, T. M. Huddleston, M. Hughes, G. T. A. Huijsmans, C. L. Hunter, P. Huynh, A. M. Hynes, D. Iglesias, N. Imazawa, F. Imbeaux, M. Imrìŝek, M. Incelli, P. Innocente, M. Irishkin, I. Ivanova-Stanik, S. Jachmich, A. S. Jacobsen, P. Jacquet, J. Jansons, A. Jardin, A. Järvinen, F. Jaulmes, S. Jednoróq, I. Jenkins, C. Jeong, I. Jepu, E. Joffrin, R. Johnson, T. Johnson, Jane Johnston, L. Joita, G. Jones, T. T. C. Jones, K. K. Hoshino, A. Kallenbach, K. Kamiya, J. Kaniewski, A. Kantor, A. Kappatou, J. Karhunen, D. Karkinsky, I. Karnowska, M. Kaufman, G. Kaveney, Y. Kazakov, V. Kazantzidis, D. L. Keeling, T. Keenan, J. Keep, M. Kempenaars, C. Kennedy, D. Kenny, J. Kent, O. N. Kent, E. Khilkevich, H. T. Kim, H. S. Kim, A. Kinch, C. King, D. King, R. F. King, D. J. Kinna, V. Kiptily, A. Kirk, K. Kirov, A. Kirschner, G. Kizane, C. Klepper, A. Klix, P. Knight, S. J. Knipe, S. Knott, T. Kobuchi, F. Köchl, G. Kocsis, I. Kodeli, L. Kogan, D. Kogut, S. Koivuranta, Y. Kominis, M. Köppen, B. Kos, T. Koskela, H. R. Koslowski, M. Koubiti, M. Kovari, E. Kowalska-Strzeciwilk, A. Krasilnikov, V. Krasilnikov, N. Krawczyk, M. Kresina, K. Krieger, A. Krivska, U. Kruezi, I. Ksiazek, A. Kukushkin, A. Kundu, T. Kurki-Suonio, S. Kwak, R. Kwiatkowski, O. J. Kwon, L. Laguardia, A. Lahtinen, A. Laing, N. Lam, H. T. Lambertz, C. Lane, P. T. Lang, S. Lanthaler, J. Lapins, A. Lasa, J. R. Last, E. Laszynska, R. Lawless, A. Lawson, K. D. Lawson, A. Lazaros, E. Lazzaro, J. Leddy, S. Lee, X. Lefebvre, H. J. Leggate, J. Lehmann, M. Lehnen, D. Leichtle, P. Leichuer, F. Leipold, I. Lengar, M. Lennholm, E. Lerche, A. Lescinskis, S. Lesnoj, E. Letellier, M. Leyland, W. Leysen, L. Li, Y. Liang, J. Likonen, J. Linke, Ch. Linsmeier, B. Lipschultz, G. Liu, Y. Liu, V. P. Lo Schiavo, T. Loarer, A. Loarte, R. C. Lobel, B. Lomanowski, P. J. Lomas, J. Lönnroth, J. M. López, J. López-Razola, R. Lorenzini, U. Losada, J. J. Lovell, A. B. Loving, C. Lowry, T. Luce, R. M. A. Lucock, A. Lukin, C. Luna, M. Lungaroni, C. P. Lungu, M. Lungu, A. Lunniss, I. Lupelli, A. Lyssoivan, N. Macdonald, P. Macheta, K. Maczewa, B. Magesh, P. Maget, C. Maggi, H. Maier, J. Mailloux, T. Makkonen, R. Makwana, A. Malaquias, A. Malizia, P. Manas, A. Manning, M. E. Manso, P. Mantica, M. Mantsinen, A. Manzanares, Ph. Maquet, Y. Marandet, N. Marcenko, C. Marchetto, O. Marchuk, M. Marinelli, M. Marinucci, T. Markovic, D. Marocco, L. Marot, C. A. Marren, R. Marshal, A. Martin, Y. Martin, A. Martín de Aguilera, F. J. Martínez, J. R. Martín-Solís, Y. Martynova, S. Maruyama, A. Masiello, M. Maslov, S. Matejcik, M. Mattei, G. F. Matthews, F. Maviglia, M. Mayer, M. L. Mayoral, T. May-Smith, D. Mazon, C. Mazzotta, R. McAdams, P. J. McCarthy, K. G. McClements, O. McCormack, P. A. McCullen, D. McDonald, S. McIntosh, R. McKean, J. McKehon, R. C. Meadows, A. Meakins, F. Medina, M. Medland, S. Medley, S. Meigh, A. G. Meigs, G. Meisl, S. Meitner, L. Meneses, S. Menmuir, K. Mergia, I. R. Merrigan, Ph. Mertens, S. Meshchaninov, A. Messiaen, H. Meyer, S. Mianowski, R. Michling, D. Middleton-Gear, J. Miettunen, F. Militello, E. Militello-Asp, G. Miloshevsky, F. Mink, S. Minucci, Y. Miyoshi, J. Mlynàr, D. Molina, I. Monakhov, M. Moneti, R. Mooney, S. Moradi, S. Mordijck, L. Moreira, R. Moreno, F. Moro, A. W. Morris, J. Morris, L. Moser, S. Mosher, D. Moulton, A. Murari, A. Muraro, S. Murphy, N. N. Asakura, Y. S. Na, F. Nabais, R. Naish, T. Nakano, E. Nardon, V. Naulin, M. F. F. Nave, I. Nedzelski, G. Nemtsev, F. Nespoli, A. Neto, R. Neu, V. S. Neverov, M. Newman, K. J. Nicholls, T. Nicolas, A. H. Nielsen, P. Nielsen, E. Nilsson, D. Nishijima, C. Noble, M. Nocente, D. Nodwell, K. Nordlund, H. Nordman, R. Nouailletas, I. Nunes, M. Oberkofler, T. Odupitan, M. T. Ogawa, T. O'Gorman, M. Okabayashi, R. Olney, O. Omolayo, M. O'Mullane, J. Ongena, F. Orsitto, J. Orszagh, B. I. Oswuigwe, R. Otin, A. Owen, R. Paccagnella, N. Pace, D. Pacella, L. W. Packer, A. Page, E. Pajuste, S. Palazzo, S. Pamela, S. Panja, P. Papp, R. Paprok, V. Parail, M. Park, F. Parra Diaz, M. Parsons, R. Pasqualotto, A. Patel, S. Pathak, D. Paton, H. Patten, A. Pau, E. Pawelec, C. Paz Soldan, A. Peackoc, I. J. Pearson, S.-P. Pehkonen, E. Peluso, C. Penot, A. Pereira, R. Pereira, P. P. Pereira Puglia, C. Perez von Thun, S. Peruzzo, S. Peschanyi, M. Peterka, P. Petersson, G. Petravich, A. Petre, N. Petrella, V. Petrzilka, Y. Peysson, D. Pfefferlé, V. Philipps, M. Pillon, G. Pintsuk, P. Piovesan, A. Pires dos Reis, L. Piron, A. Pironti, F. Pisano, R. Pitts, F. Pizzo, V. Plyusnin, N. Pomaro, O. G. Pompilian, P. J. Pool, S. Popovichev, M. T. Porfiri, C. Porosnicu, M. Porton, G. Possnert, S. Potzel, T. Powell, J. Pozzi, V. Prajapati, R. Prakash, G. Prestopino, D. Price, M. Price, R. Price, P. Prior, R. Proudfoot, G. Pucella, P. Puglia, M. E. Puiatti, D. Pulley, K. Purahoo, Th. Pütterich, E. Rachlew, M. Rack, R. Ragona, M. S. J. Rainford, A. Rakha, G. Ramogida, S. Ranjan, C. J. Rapson, J. J. Rasmussen, K. Rathod, G. Rattà, S. Ratynskaia, G. Ravera, C. Rayner, M. Rebai, D. Reece, A. Reed, D. Réfy, B. Regan, J. Regana, M. Reich, N. Reid, F. Reimold, M. Reinhart, M. Reinke, D. Reiser, D. Rendell, C. Reux, S. D. A. Reyes Cortes, S. Reynolds, V. Riccardo, N. Richardson, K. Riddle, D. Rigamonti, F. G. Rimini, J. Risner, M. Riva, C. Roach, R. J. Robins, S. A. Robinson, T. Robinson, D. W. Robson, R. Roccella, R. Rodionov, P. Rodrigues, J. Rodriguez, V. Rohde, F. Romanelli, M. Romanelli, S. Romanelli, J. Romazanov, S. Rowe, M. Rubel, G. Rubinacci, G. Rubino, L. Ruchko, M. Ruiz, C. Ruset, J. Rzadkiewicz, S. Saarelma, R. Sabot, E. Safi, P. Sagar, G. Saibene, F. Saint-Laurent, M. Salewski, A. Salmi, R. Salmon, F. Salzedas, D. Samaddar, U. Samm, D. Sandiford, P. Santa, M. I. K. Santala, B. Santos, A. Santucci, F. Sartori, R. Sartori, O. Sauter, R. Scannell, T. Schlummer, K. Schmid, V. Schmidt, S. Schmuck, M. Schneider, K. Schöpf, D. Schwörer, S. D. Scott, G. Sergienko, M. Sertoli, A. Shabbir, S. E. Sharapov, A. Shaw, R. Shaw, H. Sheikh, A. Shepherd, A. Shevelev, A. Shumack, G. Sias, M. Sibbald, B. Sieglin, S. Silburn, A. Silva, C. Silva, P. A. Simmons, J. Simpson, J. Simpson-Hutchinson, A. Sinha, S. K. Sipilä, A. C. C. Sips, P. Sirén, A. Sirinelli, H. Sjöstrand, M. Skiba, R. Skilton, K. Slabkowska, B. Slade, N. Smith, P. G. Smith, R. Smith, T. J. Smith, M. Smithies, L. Snoj, S. Soare, E. R. Solano, A. Somers, C. Sommariva, P. Sonato, A. Sopplesa, J. Sousa, C. Sozzi, S. Spagnolo, T. Spelzini, F. Spineanu, G. Stables, I. Stamatelatos, M. F. Stamp, P. Staniec, G. Stankunas, C. Stan-Sion, M. J. Stead, E. Stefanikova, I. Stepanov, A. V. Stephen, M. Stephen, A. Stevens, B. D. Stevens, J. Strachan, P. Strand, H. R. Strauss, P. Ström, G. Stubbs, W. Studholme, F. Subba, H. P. Summers, J. Svensson, L. Swiderski, T. Szabolics, M. Szawlowski, G. Szepesi, T. T. Suzuki, B. Tàl, T. Tala, A. R. Talbot, S. Talebzadeh, C. Taliercio, P. Tamain, C. Tame, W. Tang, M. Tardocchi, L. Taroni, D. Taylor, K. A. Taylor, D. Tegnered, G. Telesca, N. Teplova, D. Terranova, D. Testa, E. Tholerus, J. Thomas, J. D. Thomas, P. Thomas, A. Thompson, C.-A. Thompson, V. K. Thompson, L. Thorne, A. Thornton, A. S. Thrysoe, P. A. Tigwell, N. Tipton, I. Tiseanu, H. Tojo, M. Tokitani, P. Tolias, M. Tomes, P. Tonner, M. Towndrow, P. Trimble, M. Tripsky, M. Tsalas, P. Tsavalas, D. Tskhakaya jun, I. Turner, M. M. Turner, M. Turnyanskiy, G. Tvalashvili, S. G. J. Tyrrell, A. Uccello, Z. Ul-Abidin, J. Uljanovs, D. Ulyatt, H. Urano, I. Uytdenhouwen, A. P. Vadgama, D. Valcarcel, M. Valentinuzzi, M. Valisa, P. Vallejos Olivares, M. Valovic, M. Van De Mortel, D. Van Eester, W. Van Renterghem, G. J. van Rooij, J. Varje, S. Varoutis, S. Vartanian, K. Vasava, T. Vasilopoulou, J. Vega, G. Verdoolaege, R. Verhoeven, C. Verona, G. Verona Rinati, E. Veshchev, N. Vianello, J. Vicente, E. Viezzer, S. Villari, F. Villone, P. Vincenzi, I. Vinyar, B. Viola, A. Vitins, Z. Vizvary, M. Vlad, I. Voitsekhovitch, P. Vondràcek, N. Vora, T. Vu, W. W. Pires de Sa, B. Wakeling, C. W. F. Waldon, N. Walkden, M. Walker, R. Walker, M. Walsh, E. Wang, N. Wang, S. Warder, R. J. Warren, J. Waterhouse, N. W. Watkins, C. Watts, T. Wauters, A. Weckmann, J. Weiland, H. Weisen, M. Weiszflog, C. Wellstood, A. T. West, M. R. Wheatley, S. Whetham, A. M. Whitehead, B. D. Whitehead, A. M. Widdowson, S. Wiesen, J. Wilkinson, J. Williams, M. Williams, A. R. Wilson, D. J. Wilson, H. R. Wilson, J. Wilson, M. Wischmeier, G. Withenshaw, A. Withycombe, D. M. Witts, D. Wood, R. Wood, C. Woodley, S. Wray, J. Wright, J. C. Wright, J. Wu, S. Wukitch, A. Wynn, T. Xu, D. Yadikin, W. Yanling, L. Yao, V. Yavorskij, M. G. Yoo, C. Young, D. Young, I. D. Young, R. Young, J. Zacks, R. Zagorski, F. S. Zaitsev, R. Zanino, A. Zarins, K. D. Zastrow, M. Zerbini, W. Zhang, Y. Zhou, E. Zilli, V. Zoita, S. Zoletnik, and I. Zychor
Subjects: Physics, QC1-999
Abstract: A global heat flux model based on a fractional derivative of plasma pressure is proposed for the heat transport in fusion plasmas. The degree of the fractional derivative of the heat flux, α, is defined through the power balance analysis of the steady state. The model was used to obtain the experimental values of α for a large database of the Joint European Torus (JET) carbon-wall as well as ITER like-wall plasmas. The fractional degrees of the electron heat flux are found to be α
Published: 2020
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4. Disentangling diverse responses to climate change among global marine ecosystem models

Author: Colleen M. Petrik, Travis C. Tai, Jason D. Everett, Nicolas Barrier, Ryan F. Heneghan, Tyler D. Eddy, Eric D. Galbraith, Olivier Maury, Juliano Palacios-Abrantes, Jeroen Steenbeek, Cheryl S. Harrison, Derek P. Tittensor, Marta Coll, Hubert Du Pontavice, William W. L. Cheung, Julia L. Blanchard, Phoebe A. Woodworth-Jefcoats, Catherine M. Bulman, Anthony J. Richardson, Jan Volkholz, Maite Erauskin-Extramiana, Didier Gascuel, Jose A. Fernandes-Salvador, Jérôme Guiet, Australian Research Council, European Commission, Agence Nationale de la Recherche (France), Jarislowsky Foundation, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Fisheries and Oceans Canada, MARine Biodiversity Exploitation and Conservation (UMR MARBEC), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut de Recherche pour le Développement (IRD), Écologie et santé des écosystèmes (ESE), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institute for the Oceans and Fisheries, University of British Columbia (UBC), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), ANR-17-CE32-0008,CIGOEF,Impacts des changements climatiques sur les écosystèmes et les pêcheries océaniques globaux.(2017), and Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-AGROCAMPUS OUEST
Subjects: 0106 biological sciences, 010504 meteorology & atmospheric sciences, [SDE.MCG]Environmental Sciences/Global Changes, Climate change, Aquatic Science, Oceanography, 01 natural sciences, Modelling, Ecosystem services, Marine ecology, Structural uncertainty, Marine ecosystem, 14. Life underwater, Organism, 0105 earth and related environmental sciences, Trophic level, Biomass (ecology), business.industry, 010604 marine biology & hydrobiology, Scale (chemistry), Environmental resource management, Geology, Redistribution (cultural anthropology), 15. Life on land, FishMIP, Fish MIP, MIP, Climatic change, Climate Action, Fish, 13. Climate action, [SDE]Environmental Sciences, Environmental science, business, Fishery oceanography
Abstract: 16 pages, 6 figures, 3 tables, supplementary data https://doi.org/10.1016/j.pocean.2021.102659.-- Code and data availability: The experimental protocol in this paper has no code associated with it. Forcing data from CMIP5 used for the protocol, and the FishMIP model outputs presented in this paper are available on the ISIMIP servers (https://www.isimip.org/), Climate change is warming the ocean and impacting lower trophic level (LTL) organisms. Marine ecosystem models can provide estimates of how these changes will propagate to larger animals and impact societal services such as fisheries, but at present these estimates vary widely. A better understanding of what drives this inter-model variation will improve our ability to project fisheries and other ecosystem services into the future, while also helping to identify uncertainties in process understanding. Here, we explore the mechanisms that underlie the diversity of responses to changes in temperature and LTLs in eight global marine ecosystem models from the Fisheries and Marine Ecosystem Model Intercomparison Project (FishMIP). Temperature and LTL impacts on total consumer biomass and ecosystem structure (defined as the relative change of small and large organism biomass) were isolated using a comparative experimental protocol. Total model biomass varied between −35% to +3% in response to warming, and -17% to +15% in response to LTL changes. There was little consensus about the spatial redistribution of biomass or changes in the balance between small and large organisms (ecosystem structure) in response to warming, an LTL impacts on total consumer biomass varied depending on the choice of LTL forcing terms. Overall, climate change impacts on consumer biomass and ecosystem structure are well approximated by the sum of temperature and LTL impacts, indicating an absence of nonlinear interaction between the models’ drivers. Our results highlight a lack of theoretical clarity about how to represent fundamental ecological mechanisms, most importantly how temperature impacts scale from individual to ecosystem level, and the need to better understand the two-way coupling between LTL organisms and consumers. We finish by identifying future research needs to strengthen global marine ecosystem modelling and improve projections of climate change impacts, JDE was funded by Australian Research Council Discovery Projects DP150102656 and DP190102293. MC, JS, NB and OM received financial support by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 817578 (Triatlas project). CH received funding from the Open Philanthropy Project. NB and OM also acknowledge the support of the French ANR project CIGOEF (grant ANR-17-CE32-0008-01). DPT acknowledges funding from the ISI-MIP project to support a workshop on this topic, and the Jarislowsky Foundation. EDG received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 682602, BIGSEA). RFH was funded by the Spanish Ministry of Science, Innovation and Universities through the Acciones de Programación Conjunta Internacional (PCIN-2017-115). MC acknowledges the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S) to the Institute of Marine Science (ICM-CSIC). TDE acknowledges funding from the ISIMIP project to support a workshop on this topic and the Fisheries and Oceans Canada Atlantic Fisheries Fund. All authors declare no conflict of interest with respect to this study. JAFS received funding from the European Union’s Horizon 2020 FutureMARES project (#869300).
Published: 2021
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5. Global ensemble projections reveal trophic amplification of ocean biomass declines with climate change

Author: Heike K. Lotze, Jan Volkholz, Jacob Schewe, Susa Niiranen, David A. Carozza, Julia L. Blanchard, Yunne-Jai Shin, Tilla Roy, Charles A. Stock, Andrea Bryndum-Buchholz, Steve Mackinson, Derek P. Tittensor, Tyler D. Eddy, William W. L. Cheung, Matthias Büchner, Philippe Verley, Boris Worm, Miranda C. Jones, Elizabeth A. Fulton, Eric D. Galbraith, Jose A. Fernandes, Manuel Barange, Simon Jennings, Olivier Maury, Laurent Bopp, John P. Dunne, Ricardo Oliveros-Ramos, Tiago H. Silva, Nicolas Barrier, Daniele Bianchi, Nicola D. Walker, Marta Coll, Jeroen Steenbeek, Catherine M. Bulman, Villy Christensen, Natural Sciences and Engineering Research Council of Canada, V. Kann Rasmussen Foundation, Agence Nationale de la Recherche (France), Department for Environment, Food & Rural Affairs (UK), European Commission, Federal Ministry of Education and Research (Germany), Australian Research Council, Department of Computer Science, Hong Kong Baptist University (HKBU), Department of Earth and Planetary Sciences [Montréal] (EPS), McGill University = Université McGill [Montréal, Canada], GLOBEC IPO, Plymouth Marine Laboratory, Laboratoire de physique des océans (LPO), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS), Fisheries Centre, University of British Columbia, University of British Columbia (UBC), Institute of Marine Sciences / Institut de Ciències del Mar [Barcelona] (ICM), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), NOAA Geophysical Fluid Dynamics Laboratory (GFDL), National Oceanic and Atmospheric Administration (NOAA), CSIRO Marine and Atmosphere Research [Hobart], Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), School of Geography, University of North London, Stockholm University, Instituto del Mar del Peru (IMARPE), Food Science, FFUP, Potsdam-Institut für Klimafolgenforschung (PIK), MARine Biodiversity Exploitation and Conservation (UMR MARBEC), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut de Recherche pour le Développement (IRD), Chimie des Interactions Plasma-Surface (ChIPS) (ChIPS), Université de Mons-Hainaut, Ecopath International Initiative Research Association, Botanique et Modélisation de l'Architecture des Plantes et des Végétations (UMR AMAP), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD [France-Sud]), Defence Science and Technology Laboratory (Dstl), Ministry of Defence (UK) (MOD), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), McGill University, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), and Consejo Superior de Investigaciones Científicas [Spain] (CSIC)
Subjects: 0106 biological sciences, Aquatic Organisms, Food Chain, 010504 meteorology & atmospheric sciences, Climate Change, Oceans and Seas, Fisheries, Climate change, Atmospheric sciences, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, 01 natural sciences, [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, Theoretical, Effects of global warming, Models, global ecosystem modeling, Animals, Marine ecosystem, Intercomparison, 14. Life underwater, Biomass, Trophic cascade, uncertainty, 0105 earth and related environmental sciences, Trophic level, Biomass (ecology), marine food webs, Multidisciplinary, Ensemble forecasting, Ecology, 010604 marine biology & hydrobiology, climate change impacts, Fishes, 15. Life on land, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, Biological Sciences, Models, Theoretical, Food web, Climate Action, model intercomparison, 13. Climate action, Environmental science, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Model
Abstract: 6 pages, 5 figures, supporting information https://doi.org/10.1073/pnas.1900194116.-- All data reported in this paper are archived and publicly available at http://dataservices.gfz-potsdam.de/pik/showshort.php?id=escidoc:2956913., While the physical dimensions of climate change are now routinely assessed through multimodel intercomparisons, projected impacts on the global ocean ecosystem generally rely on individual models with a specific set of assumptions. To address these single-model limitations, we present standardized ensemble projections from six global marine ecosystem models forced with two Earth system models and four emission scenarios with and without fishing. We derive average biomass trends and associated uncertainties across the marine food web. Without fishing, mean global animal biomass decreased by 5% (±4% SD) under low emissions and 17% (±11% SD) under high emissions by 2100, with an average 5% decline for every 1 °C of warming. Projected biomass declines were primarily driven by increasing temperature and decreasing primary production, and were more pronounced at higher trophic levels, a process known as trophic amplification. Fishing did not substantially alter the effects of climate change. Considerable regional variation featured strong biomass increases at high latitudes and decreases at middle to low latitudes, with good model agreement on the direction of change but variable magnitude. Uncertainties due to variations in marine ecosystem and Earth system models were similar. Ensemble projections performed well compared with empirical data, emphasizing the benefits of multimodel inference to project future outcomes. Our results indicate that global ocean animal biomass consistently declines with climate change, and that these impacts are amplified at higher trophic levels. Next steps for model development include dynamic scenarios of fishing, cumulative human impacts, and the effects of management measures on future ocean biomass trends, Financial support was provided by the German Federal Ministry of Education and Research through ISI-MIP (Grant01LS1201A1), the European Union’s Horizon 2020 Research and Innovation Program (Grant 678193), and the Ocean Frontier Institute (Module G). We acknowledge additional financial support as follows: to H.K.L., W.W.L.C., and B.W. from the Natural Sciences and Engineering Research Council (NSERC) of Canada; to D.P.T. from the Kanne Rasmussen Foundation Denmark; to A.B.-B. from the NSERC Transatlantic Ocean Science and Technology Program; to W.W.L.C. and T.D.E. from the Nippon Foundation-Nereus Program; to E.D.G., M.C. and J. Steenbeek from the European Union’s Horizon 2020 Re-search and Innovation Program (Grants 682602 and 689518); to E.A.F., J.L.B., andT.R. from Commonwealth Scientific and Industrial Research Organization and the Australian Research Council; to N.B., L.B., and O.M. from the French Agence Nationale de la Recherche and Pôle de Calcul et de Données pour la Mer; and to S.J. from the UK Department of Environment, Food and Rural Affairs
Published: 2019
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6. Ensemble projections of global ocean animal biomass with climate change

Author: Nicola D. Walker, Marta Coll, Charles A. Stock, John P. Dunne, Laurent Bopp, Derek P. Tittensor, Ricardo Oliveros-Ramos, Tilla Roy, Philippe Verley, Steve Mackinson, Tiago H. Silva, Simon Jennings, Susa Niiranen, David A. Carozza, Heike K. Lotze, Jan Volkholz, Manuel Barange, Elizabeth A. Fulton, Matthias Büchner, Jacob Schewe, Miranda C. Jones, Villy Christensen, Tyler D. Eddy, Catherine M. Bulman, Andrea Bryndum-Buchholz, William W. L. Cheung, Jose A. Fernandes, Yunne-Jai Shin, Eric D. Galbraith, Jeroen Steenbeek, Julia L. Blanchard, Olivier Maury, Nicolas Barrier, and Daniele Bianchi
Subjects: 0106 biological sciences, Biomass (ecology), 010504 meteorology & atmospheric sciences, 010604 marine biology & hydrobiology, Fishing, Climate change, 15. Life on land, 01 natural sciences, Standard deviation, Latitude, 13. Climate action, Abundance (ecology), Climatology, Environmental science, Marine ecosystem, Ecosystem, 14. Life underwater, 0105 earth and related environmental sciences
Abstract: Climate change is shifting the abundance and distribution of marine species with consequences for ecosystem functioning, seafood supply, management and conservation. Several approaches for future projection exist but these have never been compared systematically to assess their variability. We conducted standardized ensemble projections including 6 global fisheries and marine ecosystem models, forced with 2 Earth-system models and 4 emission scenarios in a fished and unfished ocean, to derive average trends and associated uncertainties. Without fishing, mean global animal biomass decreased by 5% (±4%) under low and 17% (±11%) under high emissions by 2100, primarily driven by increasing temperature and decreasing primary production. These climate-change effects were slightly weaker for larger animals and in a fished ocean. Considerable regional variation ranged from strong biomass increases in high latitudes to strong decreases in mid-low latitudes, with good model agreement on the direction of change but variable magnitude. Uncertainties due to differences among ecosystem or Earth-system models were similar, suggesting equal need for model improvement. Our ensemble projections provide the most comprehensive outlook on potential climate-driven ecological changes in the ocean to date. Realized future trends will largely depend on how fisheries and management adapt to these changes in a changing climate.
Published: 2018
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7. Sarcoma in neurofibromatosis 2:case report and review of the literature

Author: Miriam J. Smith, Andrew J Wallace, D C Mangham, Anthony J. Freemont, M Bulman, D G R Evans, and C Linder
Subjects: 0301 basic medicine, Adult, Male, Cancer Research, Pathology, medicine.medical_specialty, Neurofibromatosis 2, Delayed Diagnosis, 030105 genetics & heredity, Schwannoma, Malignancy, Diagnosis, Differential, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Fatal Outcome, Immunochemistry, Antineoplastic Combined Chemotherapy Protocols, Genetics, medicine, otorhinolaryngologic diseases, Humans, Retroperitoneal Neoplasms, SMARCB1, Neurofibromatosis type 2, Neurofibromatosis, Genetics (clinical), Neurofibromin 2, Spinal Neoplasms, business.industry, Palliative Care, Sarcoma, SMARCB1 Protein, Sorafenib, medicine.disease, Oncology, Doxorubicin, 030220 oncology & carcinogenesis, Neoplasm Grading, Complication, business
Abstract: Neurofibromatosis type 2 (NF2) is associated with the development of several types of benign nervous system tumours, while malignancies are rare. We report a 22-year-old man who presented with retroperitoneal and spinal high-grade sarcomas with epithelial features. Samples showed a mixed epithelioid and spindled cell content with little associated matrix and inconclusive immunochemistry. Genetic analysis of a schwannoma and matched blood samples demonstrated a constitutional de novo substitution at the splice donor site of intron 8 of the NF2 gene and aa acquired large deletion of the entire NF2 gene as a second hit, with some loss of SMARCB1. The sarcoma also showed evidence of loss of SMARCB1 and NF2 with loss of INI1 staining. Unfortunately the mass was unresectable and the patient died 6 months after diagnosis. This malignancy was most consistent with SMARCB1-deficient epithelioid malignant peripheral nerve sheath tumour, although a significant differential was proximal-type epithelial sarcoma. Each differential has previously been reported only once with NF2. This demonstrates an extremely rare potential complication of the condition.
Published: 2018
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8. Overview of the JET results in support to ITER

Author: Alfredo Pironti, J. Simpson-Hutchinson, Sean Conroy, J. Uljanovs, D. Middleton-Gear, G. Possnert, C. Angioni, R. McAdams, Nicholas Watkins, E. Fortuna-Zalesna, A. Garcia-Carrasco, K. Gałązka, D. Nodwell, Pasquale Gaudio, R.A. Pitts, Svetlana V. Ratynskaia, Seppo Koivuranta, O. J. Kwon, C. Boyd, A. Boboc, M. Reinhart, Igor Lengar, Jarrod Leddy, Hiroyasu Utoh, J. H. Ahn, A. Stevens, J. Lönnroth, U. Kruezi, C. Guillemaut, N. Fonnesu, W. Studholme, Marek Rubel, P. Cahyna, O. McCormack, A. S. Jacobsen, D. Mazon, Gunta Kizane, N. Ashikawa, William Tang, J. Goff, F. Nespoli, Thomas Giegerich, G. Petravich, Angela Busse, Corneliu Porosnicu, M. Bigi, M. Wheatley, Christopher N. Bowman, J. Zacks, Ivan Calvo, U. Losada, H. Weisen, B. Bauvir, Stanislas Pamela, Sylvain Brémond, M.F. Stamp, Scott W. McIntosh, A. Rakha, S. Glöggler, V. Braic, C. Bottereau, S. Murphy, S. Knott, Luigi Fortuna, P. Bunting, N. Vora, S. D. Scott, A. Lazaros, R. Dejarnac, P. Buratti, H.R. Strauss, Gabriele Croci, M. Nocente, A. Hollingsworth, S. Reynolds, D. J. Wilson, D. D. Brown, T.C. Luce, S. Zoletnik, E. Nilsson, L. Laguardia, O. Marchuk, F.P. Orsitto, E. Cecil, V. Huber, J. B. Girardo, Stylianos Varoutis, M. D. Axton, Hyun-Tae Kim, E. Safi, Ch. Day, S. Arshad, J. Rzadkiewicz, P. Prior, A. Meigs, S. Esquembri, P. Gohil, K. Purahoo, Torbjörn Hellsten, N. Tipton, R. Guirlet, E. Joffrin, V. Aldred, Calin Besliu, M. Valentinuzzi, G. T. Jones, J. Edwards, Giuseppe Ambrosino, Laurent Marot, N. Lam, F. Crisanti, G. Verona Rinati, R. Marshal, Michael L. Brown, D. Frigione, D. Chandra, Michaele Freisinger, R. Olney, Jari Varje, S. Whetham, F. Parra Diaz, M. R. Hough, P. Dinca, F. Salzedas, A. Goodyear, R. Gowland, J. A. Wilson, J. Horacek, D. King, K. Flinders, I. R. Merrigan, M. Ghate, R. Michling, F. Saint-Laurent, G. Kocsis, D. Van Eester, C. Young, R. O. Dendy, A. Meakins, N. Pace, C. L. Hunter, D. Alegre, S. Foster, V. Riccardo, M. Bulman, C. Jeong, Marek Szawlowski, B. D. Whitehead, Vasily Kiptily, James Harrison, Hiroshi Tojo, G. T. A. Huijsmans, J. W. Coenen, X. Litaudon, Justin Williams, C. Hidalgo, S. Lesnoj, I.E. Day, A. W. Morris, R. Mooney, Yann Corre, S. Brezinsek, B. Gonçalves, M. Kresina, D. Coombs, F. Köchl, J. L. Gardarein, W. Davis, Aqsa Shabbir, Kanti M. Aggarwal, L. Colas, A. B. Kukushkin, Seppo Sipilä, Elisabeth Rachlew, Leena Aho-Mantila, O. G. Pompilian, E. Viezzer, Shane Cooper, Fabio Villone, P. Blanchard, Patrick Tamain, P. Camp, T. Szabolics, C. Luna, Kalle Heinola, H. G. Esser, V. Bobkov, James Buchanan, Andrew West, Hajime Urano, Roberta Lima Gomes, J.P. Coad, Th. Pütterich, A. Sinha, S. Hollis, R. D. Wood, G. D. Ewart, F. S. Griph, T. Kobuchi, X. Lefebvre, S. Warder, A.J. Thornton, S. Peschanyi, B. Graham, Giuseppe Telesca, M. Kempenaars, J. Bernardo, M. Hughes, Eva Belonohy, S. Schmuck, Kai Nordlund, T. J. Smith, P. Hertout, K. D. Lawson, M. Brix, Matthew Sibbald, Grégoire Hornung, C. Tame, Matthew Carr, S. Wray, P. T. Doyle, A. Somers, Giuseppe Chitarin, D. C. Campling, Mitul Abhangi, I. Jepu, David A. Wood, J. Miettunen, A. Sopplesa, Raffaele Fresa, S. Saarelma, M. Bacharis, J. Pozzi, P. Vallejos Olivares, Teddy Craciunescu, Raffaele Albanese, S. Knipe, Jason P. Byrne, A. C. C. Sips, S. Hazel, V. Kazantzidis, G. Stankūnas, A. Kundu, J. Mailloux, C. Guerard, Pramit Dutta, J. E. Boom, Eduardo Alves, P. Grazier, Saskia Mordijck, V.S. Neverov, Kazuo Hoshino, A. P. Vadgama, P. D. Brennan, P. Innocente, Piergiorgio Sonato, M. Irishkin, M. Berry, D. W. Robson, Dieter Leichtle, Fabio Pisano, P. McCullen, T. M. Huddleston, Kensaku Kamiya, D. Pacella, Tommy Ahlgren, A. Kirschner, B. Magesh, A. Ash, J. Mlynář, C. Castaldo, C. Marchetto, D. L. Hillis, M. Incelli, B. Viola, R. J. Robins, E. Andersson Sundén, G. Ramogida, Matthew Reinke, Gerd Meisl, Yannis Kominis, R. Proudfoot, C. Noble, N. J. Conway, V. P. Lo Schiavo, Jorge Luis Rodriguez, Hugo Bufferand, C. H. A. Hogben, B. Evans, R. Sartori, H. Greuner, M. G. Dunne, K. Schöpf, M. I. K. Santala, E. Giovannozzi, A. E. Shevelev, C. Gil, P. Boulting, P. Sagar, A.E. Shumack, P. A. Coates, C. Ayres, R. Prakash, C. Giroud, M. Parsons, J. C. Giacalone, S. Meshchaninov, A. Peackoc, G. De Temmerman, A.C.A. Figueiredo, D. Gallart, P. Santa, Sergey Popovichev, Ivan Lupelli, M. Valovic, Thomas Johnson, Y. Martynova, M. Rack, Olivier Sauter, J. Garcia, P. Siren, I. Balboa, S. Lee, Hans Nordman, R. Roccella, M. Faitsch, Julien Hillairet, Patrick J. McCarthy, C. Reux, Irena Ivanova-Stanik, V. Coccorese, Ye. O. Kazakov, R. El-Jorf, C. Hamlyn-Harris, Matthias Weiszflog, C. F. Maggi, Panagiotis Tolias, N. C. Hawkes, E. Clark, Bruno Santos, B. Sieglin, R. Rodionov, Roch Kwiatkowski, P. Denner, C. Woodley, Hugh Summers, Francesco Pizzo, G. Pucella, D. Croft, F. Di Maio, M. Tomes, D. Molina, A. Fernades, L. Amicucci, Marco Cecconello, A. Bisoffi, Z. Ul-Abidin, J. Wilkinson, H. Maier, S. Rowe, M. Beckers, P.J. Knight, E. Pajuste, Choong-Seock Chang, K. Deakin, M. Enachescu, A. Cobalt, D. Tskhakaya Jun, Michela Gelfusa, Rémy Nouailletas, R. Ragona, N. Bonanomi, D. A. Homfray, K. Riddle, Yann Camenen, J. D. Thomas, R.P. Doerner, Timothy P. Robinson, Y. Miyoshi, Ph. Jacquet, H. T. Lambertz, D. Pulley, A. Bécoulet, E. Tholerus, O. Bogar, M. Peterka, R. Crowe, C. Sommariva, A. R. Talbot, N. K. Butler, N. Reid, R. Zagórski, Gerald Pintsuk, Juri Romazanov, Andre Neto, G. L. Ravera, Paolo Arena, A. Manning, F. Durodié, Maryna Chernyshova, D. Karkinsky, Štefan Matejčík, J. P. Thomas, A. Wilson, L. Joita, R. Naish, P. Strand, M. Balden, M. Kaufman, T. Powell, V. Schmidt, D. Barnes, José Vicente, S. Doswon, Daniel F. Valcarcel, Claudia Corradino, R. Warren, Annette M. Hynes, J. D. Strachan, A. M. Messiaen, M. Kovari, O. Omolayo, D. M. Witts, R. C. Felton, C. Fleming, C. A. Marren, Patrick Maget, J. Galdon-Quiroga, H. R. Koslowski, Bruce Lipschultz, Ana Elisa Bauer de Camargo Silva, J. Waterhouse, R. J. Dumont, M. Schneider, Sara Moradi, K. J. Nicholls, M. Beldishevski, Benedikt Geiger, A. Jardin, A. Ekedahl, A. Lyssoivan, C. Waldon, Davide Galassi, F. Jaulmes, A. Kirk, Yannick Marandet, F. Hasenbeck, Gabor Szepesi, R. C. Pereira, J. Juul Rasmussen, Nobuyuki Aiba, Michelle E. Walker, Gábor Cseh, Scott W. Mosher, R. Bastow, A. Di Siena, E. Lazzaro, M. Curuia, C. D. Challis, Z. Ghani, J. Deane, João M. C. Sousa, Henrik Sjöstrand, T. O'Gorman, H. R. Wilson, P. Devynck, M. Price, C. A. Thompson, Daniele Marocco, A. Cullen, M. Clark, M. Lennholm, D. Carralero, N. Balshaw, Roland Sabot, I. Stepanov, N. Petrella, Filippo Sartori, L. W. Packer, P. Thomas, M. Lungu, A. V. Krasilnikov, R. Young, Jonathan Graves, J. C. Hillesheim, Mǎdǎlina Vlad, Duccio Testa, Pierre Dumortier, Paulo Carvalho, M. Gosk, Yong-Su Na, M. Buckley, Carlos A. Silva, V. Fuchs, K. Vasava, P. A. Tigwell, B. Wakeling, M. Medland, M. Bellinger, K. Gal, Petter Ström, E. Veshchev, F. Nabais, A. Wynn, L. Lauro Taroni, B. Beckett, L. Gil, M. Towndrow, Brian Grierson, Harry M. Meyer, V. Philipps, A. de Castro, D. Kinna, D. Conka, Göran Ericsson, L. Piron, J. Hawkins, D. Cooper, Kenneth Hammond, V.V. Parail, Cristian Ruset, G.J. van Rooij, M. N. A. Beurskens, N. Fawlk, G. Evison, M. Van De Mortel, N. Marcenko, B. Slade, Th. Franke, Simone Peruzzo, N. den Harder, D. Baião, A. Martin de Aguilera, Frederic Imbeaux, Carlo Sozzi, J.L. de Pablos, J. Svensson, A. Withycombe, Ane Lasa, H. Sheikh, V.A. Yavorskij, Nick Walkden, E. Lerche, C. S. Gibson, Roberto Zanino, Y. Peysson, David Hatch, B. Bazylev, E. de la Cal, S. Hacquin, T. D. V. Haupt, S. A. Silburn, T.T.C. Jones, Maria Teresa Porfiri, Walid Helou, S. E. Sharapov, M. Zerbini, Ken W Bell, Marco Marinelli, Kyriakos Hizanidis, J. M. Fontdecaba, N. Teplova, K. K. Kirov, S. Vartanian, W. W. Pires de Sa, T. C. Hender, J. K. Blackburn, I. Monakhov, H. Patten, P. A. Simmons, Y. Austin, J. Regana, Stefano Coda, Amanda J. Page, D. Fuller, António J.N. Batista, A. Horton, P. Heesterman, S. Cramp, J. Hobirk, F. Clairet, A. Burckhart, M. Allinson, Larry R. Baylor, W. Leysen, D. B. Gin, P. Nielsen, A. Kantor, Yueqiang Liu, A.V. Stephen, Jose Ramon Martin-Solis, P. Mantica, B. C. Regan, Aleksander Drenik, A. Lukin, L. Thorne, G. Nemtsev, J. Denis, M. E. Graham, D. Rigamonti, W. Van Renterghem, M. Tardocchi, M. Koubiti, A. Malaquias, M. Tsalas, A. Cufar, Giuseppe Prestopino, D. Kogut, N. Pomaro, J. Keep, Jochen Linke, Shimpei Futatani, Boris Breizman, A. Sirinelli, M. Chandler, M. Fortune, F. Degli Agostini, I. Jenkins, T. Spelzini, G. Calabrò, O. N. Kent, A. Lunniss, Etienne Hodille, Z. Vizvary, Volker Naulin, T. Eich, F. Mink, A. Alkseev, P. W. Haydon, Massimo Angelone, Norberto Catarino, J. Lapins, Roberto Pasqualotto, R. Lawless, T. Schlummer, F. Bonelli, M. Wischmeier, Stéphane Devaux, G. Saibene, Dirk Reiser, Y. R. Martin, H. Bergsåker, Jon Godwin, Alessia Santucci, C. Lane, Justyna Grzonka, Ph. Mertens, Claudio Verona, David Moulton, E. Delabie, Anna Salmi, P. G. Smith, T. Bolzonella, Silvio Ceccuzzi, Ulrich Fischer, G. Liu, M. A. Henderson, M. Marinucci, T. Suzuki, Jakub Bielecki, João Figueiredo, M. Afzal, J. Cane, Robert Hager, Luciano Bertalot, M. Firdaouss, G. Tvalashvili, D. Hepple, D. Esteve, M. De Bock, Y. Baranov, R. D'Inca, G. De Tommasi, Ch. Linsmeier, T. Nicolas, I. J. Pearson, P. Finburg, Ireneusz Książek, S. Talebzadeh, A. Czarnecka, A. Botrugno, M. Gethins, Bohdan Bieg, R. Baughan, I. Borodkina, B. Kos, A. Muraro, T. Vasilopoulou, G. Hermon, S.J. Wukitch, Jari Likonen, D. P. Coster, Guglielmo Rubinacci, I. H. Coffey, Justine M. Kent, S. E. Dorling, J. Dankowski, Geert Verdoolaege, Daisuke Nishijima, R. Clarkson, E. R. Solano, M. Stephen, A. Lescinskis, P. Staniec, Karl Schmid, M. Mayer, Peter Lang, T. Franklin, M.I. Williams, C. G. Elsmore, F. Maviglia, C. Di Troia, C. Penot, A. Zarins, Pierre Manas, D. F. Gear, Yu Gao, Philipp Drews, E. Letellier, A. S. Thompson, L. Forsythe, I. Zychor, E. Khilkevich, A. Manzanares, T. Nakano, Paulo Rodrigues, J. Edmond, Sebastián Dormido-Canto, R. Dux, C. Appelbee, L. Moser, Angelo Cenedese, D. Fagan, N. Richardson, Giuseppe Gorini, V. Rohde, R. Paprok, João P. S. Bizarro, P. Aleynikov, M. Sertoli, Ł. Świderski, Simone Palazzo, O. W. Davies, D. Douai, N. Macdonald, M. Baruzzo, J. López-Razola, M. Lungaroni, D. Clatworthy, R. Bravanec, J. Lovell, Ambrogio Fasoli, S.-P. Pehkonen, M. E. Puiatti, P. Papp, G. Bodnar, V. Aslanyan, A. Weckmann, K. A. Taylor, R. Henriques, I. T. Chapman, Ewa Pawelec, Miles M. Turner, Steven J. Meitner, M. Bernert, Ph. Maquet, R. C. Meadows, A. Shaw, N. Vianello, L. Barrera Orte, Tomas Markovic, A. Fil, A. S. Couchman, Inessa Bolshakova, J. Fyvie, Konstantina Mergia, J. Gallagher, R.V. Budny, Frank Leipold, C. J. Rapson, R. C. Lobel, Gennady V. Miloshevsky, K.-D. Zastrow, Ph. Duckworth, Gianluca Rubino, G. Withenshaw, S. Maruyama, S. P. Hallworth Cook, M. Newman, Jérôme Bucalossi, P. Drewelow, Nuno Cruz, D. Iglesias, I. Nedzelski, T. Donne, P. Leichuer, R. Cesario, M. D. J. Bright, T. Boyce, N. Imazawa, Per Petersson, R. King, A. Loving, L. Garzotti, Jorge Ferreira, G. Corrigan, D. Sandiford, B. Tal, P. Puglia, Daniel Tegnered, J. Karhunen, James S. Wright, Tom Wauters, J. McKehon, K. Rathod, Olivier Février, Alessandro Formisano, Petra Bilkova, M. Groth, Ricardo Magnus Osorio Galvao, F. Medina, S. Collins, H. J. Boyer, Elena Bruno, Horacio Fernandes, M. J. Stead, R. Paccagnella, J. Kaniewski, Ion E. Stamatelatos, F. Causa, M. F. F. Nave, A. Patel, D. C. McDonald, L. Moreira, Mariano Ruiz, K. Dylst, Raymond A. Shaw, A. Brett, Jane Johnston, P. P. Pereira Puglia, J. Ongena, N. A. Benterman, V. N. Amosov, Christian Grisolia, J. Simpson, C. Perez von Thun, Jan Weiland, P. Tonner, F. Belli, T. Odupitan, T. Dittmar, Edmund Highcock, Taina Kurki-Suonio, I. Uytdenhouwen, Estelle Gauthier, M. Oberkofler, B. Alper, Iris D. Young, S. Soare, Yuji Hatano, D. Reece, D. Borodin, M. Moneti, W. Yanling, S. Mianowski, K. Fenton, Stephen J. Bailey, R. Coelho, Sandra C. Chapman, E. Łaszyńska, A. R. Field, F.J. Martínez, Anders Nielsen, M. Smithies, M. J. Mantsinen, A. J. Capel, N. D. Smith, A. Pires dos Reis, M.-L. Mayoral, T. Loarer, P. Carman, N. Grazier, S. Breton, J. M. A. Bradshaw, Alexandre C. Pereira, Fulvio Auriemma, Fulvio Militello, Barbara Cannas, D. Ulyatt, A. Kappatou, P. Blatchford, R. Scannell, B. I. Oswuigwe, Darren Price, Robert E. Grove, D. Guard, M. Leyland, G. Stubbs, J. W. Banks, V.V. Plyusnin, M. S. J. Rainford, Andrea Murari, Sanjeev Ranjan, A. Huber, V. Krasilnikov, C. Bower, H. Leggate, S. Abduallev, P. Tsavalas, G. Giruzzi, K. Maczewa, Colin Roach, P. Beaumont, R. P. Johnson, Anna Widdowson, L. A. Kogan, A. Baron Wiechec, Markus Airila, J. Morris, Robert Skilton, Katarzyna Słabkowska, M. A. Barnard, Jean-Paul Booth, Alessandro Pau, R. Price, R. Bament, M. Tokitani, I. Turner, T. Vu, P. Huynh, S.N. Gerasimov, D. I. Refy, Yunfeng Liang, Anders Hjalmarsson, S. Dalley, Roberto Ambrosino, O. Hemming, T. R. Blackman, Y. Zhou, Vasile Zoita, P. Vincenzi, A. Loarte, C. Rayner, Martin Imrisek, M. Tripsky, C. Mazzotta, A. Uccello, V. Basiuk, Lide Yao, V. Goloborod'ko, S. Villari, B. P. Duval, N. Bulmer, W. Zhang, L. Hackett, D. N. Borba, M. Halitovs, Mario Pillon, H. Arnichand, Alberto Alfier, A. Lawson, A. Masiello, T. Makkonen, A. Vitins, D. Rendell, D. Paton, L. Avotina, A. Krivska, M. Maslov, Richard Verhoeven, Marc Goniche, A. Broslawski, Marica Rebai, E. de la Luna, E. Militello-Asp, V. Cocilovo, L. Carraro, Michael Fitzgerald, Bernardo B. Carvalho, D. Young, C.G. Lowry, F. J. Casson, L.-G. Eriksson, T. M. Biewer, B. Esposito, F.G. Rimini, J. Fessey, G. Kaveney, S. Hall, Robin Barnsley, Michael Lehnen, N. Bekris, L. F. Ruchko, P. Batistoni, E. Alessi, M. G. O'Mullane, D. S. Darrow, C. N. Grundy, N. Hayter, Ivo S. Carvalho, M. Brombin, Enrico Zilli, M. Valisa, M. Reich, S. Panja, C. Gurl, Charles Harrington, Emmanuele Peluso, M. Porton, Michael Walsh, D. Falie, A. Reed, Jacob Eriksson, P. Macheta, J. M. Faustin, S. Cortes, S. Fietz, P. Piovesan, D. Ciric, Eric Nardon, R. Neu, Bojiang Ding, G.A. Rattá, F. Reimold, R. Craven, M. Cox, J. Orszagh, Aaro Järvinen, A. S. Thrysøe, A. Shepherd, I. Ďuran, Andrew M. Edwards, A. Kinch, J. Beal, M. Gherendi, Martin Köppen, D. Samaddar, P. Dalgliesh, I. Vinyar, J. Jansons, Nengchao Wang, J. Wu, John Wright, S. Wiesen, C. King, Alessandra Fanni, L. D. Horton, N. Krawczyk, J. Buch, K. Krieger, Václav Petržílka, D. Schworer, C. Watts, T. Keenan, Andrea Malizia, B. D. Stevens, P. Trimble, C. P. Lungu, V. Prajapati, Marco Ariola, C. Wellstood, S. Gilligan, Mirko Salewski, Michael Barnes, Florin Spineanu, H. Doerk, C. Kennedy, S. Jachmich, J. Caumont, Isabel L. Nunes, A. Petre, A. Kallenbach, M. Anghel, B. Lomanowski, Marco Riva, M. Romanelli, G. De Masi, T. May-Smith, T. Xu, A. Goussarov, S. Romanelli, M. Okabayashi, A. Baker, R. Salmon, T. Tala, Nicolas Fedorczak, S. Lanthaler, Giuliana Sias, J. Risner, Clarisse Bourdelle, M. E. Manso, Fabio Moro, R. Lucock, M. Bassan, M. T. Ogawa, V. Thompson, A. M. Whitehead, S. D. A. Reyes Cortes, Igor Bykov, Gennady Sergienko, E. Stefanikova, Mattia Frasca, H. Dabirikhah, Lorenzo Frassinetti, N. Dzysiuk, D. L. Keeling, Juan Manuel López, M. Turnyanskiy, Daniel Dunai, David Taylor, Arturo Buscarino, Carolina Björkas, A. Baciero, S. Meigh, M. Garcia-Munoz, Massimiliano Mattei, M. Hill, Gwyndaf Evans, S. Minucci, Xiang Gao, A. V. Chankin, Francesco Romanelli, A. Lahtinen, L. Giacomelli, A. Owen, Jesús Vega, Jonathan Citrin, Antti Hakola, Petr Vondracek, Sehyun Kwak, P. Abreu, L. Meneses, S. S. Medley, G. Gervasini, Surya K. Pathak, Kristel Crombé, M. Cleverly, H.S. Kim, C. Stan-Sion, Nobuyuki Asakura, E. Wang, A. Cardinali, L. Fazendeiro, R. Cavazzana, P. J. Lomas, J. Hawes, G. Stables, Silvia Spagnolo, S. P. Hotchin, N. R. Green, Slawomir Jednorog, Ewa Kowalska-Strzęciwilk, A. Martin, Linwei Li, Rajnikant Makwana, Richard Goulding, I. Voitsekhovitch, M. Bowden, I. Kodeli, Peter Hawkins, S. S. Henderson, Ondrej Ficker, Carl Hellesen, D. Yadikin, Fabio Subba, Luka Snoj, Anthony Laing, N. Ben Ayed, Mario Cavinato, M. Goodliffe, C. Clements, D. Kenny, Axel Klix, S. Gee, R. J. E. Smith, P. de Vries, L. Fittill, Min-Gu Yoo, S. Menmuir, K. Cave-Ayland, S. Potzel, D. Grist, K. Blackman, S. A. Robinson, Rodney Walker, David Pfefferlé, W. Broeckx, D. Harting, S. G. J. Tyrrell, F. Binda, L. Horvath, Davide Flammini, P. V. Edappala, Raul Moreno, G. M. D. Hogeweij, P. Card, A. Hagar, Ion Tiseanu, Rita Lorenzini, L. Appel, Jet Contributors, J. Flanagan, C. Paz Soldan, U. Samm, Otto Asunta, F. Eriksson, C. Taliercio, F. S. Zaitsev, G. F. Matthews, Tuomas Koskela, P. J. Howarth, D. Terranova, M. Skiba, Amanda Hubbard, R. Otin, K. G. McClements, M. Park, R. McKean, C. Christopher Klepper, I. Karnowska, Peter J. Pool, G. Ciraolo, Jennifer M. Lehmann, Institut de Mécanique des Fluides et des Solides (IMFS), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), VTT Technical Research Centre of Finland (VTT), Association EURATOM-TEKES, Association EURATOM-TEKES, Helsinki University of Technology, Finland, Assoc. Euratom-ENEA-CREATE, Universita Mediterranea of Reggio Calabria [Reggio Calabria], EURATOM/CCFE Fusion Association, Culham Science Centre [Abingdon], Instituto Tecnológico e Nuclear (ITN), ITN, University of Naples Federico II = Università degli studi di Napoli Federico II, Max-Planck-Institut für Plasmaphysik [Garching] (IPP), Università degli studi di Catania = University of Catania (Unict), National Institute for Fusion Science (NIFS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), ITER organization (ITER), Karlsruhe Institute of Technology (KIT), Institut de Chimie des Substances Naturelles (ICSN), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), European Fusion Development Agreement [Garching bei München] ( EFDA-CSU), Institut d'ophtalmologie Hédi-Rais de Tunis, Service Cardiologie [CHU Toulouse], Pôle Cardiovasculaire et Métabolique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), H. Niewodniczanski Institute of Nuclear Physics, Polska Akademia Nauk = Polish Academy of Sciences (PAN), Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique (LHEEA), École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Euratom/UKAEA Fusion Assoc., Magnetic Sensor laboratory [Lviv] (MSL), National Polytechnic University of Lviv (LPNU), The National Research Nuclear University MEPhI (Moscow Engineering Physics Institute) [Moscow, Russia], Institute of Energy and Climate Research - Plasma Physics (IEK-4), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association-Helmholtz-Gemeinschaft = Helmholtz Association, Institute for Problems of Material Science, National Academy of Sciences of Ukraine (NASU), Institute of Plasma Physics [Praha], Czech Academy of Sciences [Prague] (CAS), Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Département Méthodes et Modèles Mathématiques pour l'Industrie (3MI-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Centre G2I, Department of Hydraulics, Transportations and Roads, Laboratoire de microbiologie et génétique moléculaires - UMR5100 (LMGM), Centre de Biologie Intégrative (CBI), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Metallurgical & Materials Engineering Department (MS 388), University of Nevada [Reno], AUTRES, Institute of Plasma Physics and Laser Microfusion [Warsaw] (IPPLM), Culham Centre for Fusion Energy (CCFE), Astrophysics Research Centre [Belfast] (ARC), Queen's University [Belfast] (QUB), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), School of Mathematics [Cardiff], Cardiff University, Associazone EURATOM ENEA sulla Fusione, EURATOM, Laboratoire de physique des plasmas de l'ERM, Laboratorium voor plasmafysica van de KMS (LPP ERM KMS), Ecole Royale Militaire / Koninklijke Militaire School (ERM KMS), Paul-Drude-Institut für Festkörperelektronik (PDI), Institut für Physik, University of Basel (Unibas), Dutch Institute for Fundamental Energy Research [Nieuwegein] (DIFFER), Dutch Institute for Fundamental Energy Research [Eindhoven] (DIFFER), Institut Jean Lamour (IJL), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), CEA Cadarache, Dipartimento di Energia [Milano], Politecnico di Milano [Milan] (POLIMI), Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Lille économie management - UMR 9221 (LEM), Université d'Artois (UA)-Université catholique de Lille (UCL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Euratom research and training programme 633053, Institut de Mécanique des Fluides et des Solides ( IMFS ), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS ), VTT Technical Research Centre of Finland ( VTT ), Univ. Mediterranea RC, Culham Science Centre, Instituto Tecnológico e Nuclear ( ITN ), Università degli studi di Napoli Federico II, Max-Planck-Institut für Plasmaphysik [Garching] ( IPP ), Università degli studi di Catania [Catania], National Institute for Fusion Science, National Institutes of Natural Sciences, Laboratoire de Physique Nucléaire et de Hautes Énergies ( LPNHE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), School of Geography, Earth and Environmental Sciences, ITER Organization, Karlsruhe Institute of Technology ( KIT ), Laboratoire de Nanotechnologie et d'Instrumentation Optique ( LNIO ), Institut Charles Delaunay ( ICD ), Université de Technologie de Troyes ( UTT ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Technologie de Troyes ( UTT ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Chimie des Substances Naturelles ( ICSN ), Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherche sur la Fusion par confinement Magnétique ( IRFM ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), European Fusion Development Agreement [Garching bei München] ( EFDA-CSU ), Service de cardiologie [Toulouse], Université Paul Sabatier - Toulouse 3 ( UPS ) -CHU Toulouse [Toulouse]-Hôpital de Rangueil, ITER [St. Paul-lez-Durance], ITER, Polska Akademia Nauk ( PAN ), Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique ( LHEEA ), École Centrale de Nantes ( ECN ) -Centre National de la Recherche Scientifique ( CNRS ), MSL, Lviv Polytechnic National University ( MSL ), Lviv Polytechnic National University, Centre d'études et de recherches appliquées à la gestion ( CERAG ), Université Pierre Mendès France - Grenoble 2 ( UPMF ) -Centre National de la Recherche Scientifique ( CNRS ), Institute of Energy and Climate Research - Plasma Physics ( IEK-4 ), Forschungszentrum Jülich GmbH, National Academy of Sciences of Ukraine ( NASU ), Lille - Economie et Management ( LEM ), Université catholique de Lille ( UCL ) -Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), Czech Academy of Sciences [Prague] ( ASCR ), Physique des interactions ioniques et moléculaires ( PIIM ), Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Département Méthodes et Modèles Mathématiques pour l'Industrie ( 3MI-ENSMSE ), École des Mines de Saint-Étienne ( Mines Saint-Étienne MSE ), Institut Mines-Télécom [Paris]-Institut Mines-Télécom [Paris]-Centre G2I, Laboratoire de microbiologie et génétique moléculaires ( LMGM ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Centre National de la Recherche Scientifique ( CNRS ), University of Nevada, Institute of Plasma Physics and Laser Microfusion [Warsaw] ( IPPLM ), UCL Department of Space and Climate Physics, University College of London [London] ( UCL ), Astrophysics Research Centre [Belfast] ( ARC ), Queen's University [Belfast] ( QUB ), Laboratoire d'Electronique et des Technologies de l'Information ( CEA-LETI ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Grenoble Alpes [Saint Martin d'Hères], Cardiff School of Mathematics, Laboratoire de physique des plasmas de l'ERM, Laboratorium voor plasmafysica van de KMS ( LPP ERM KMS ), Ecole Royale Militaire / Koninklijke Militaire School ( ERM KMS ), Paul-Drude-Institut für Festkörperelektronik, University of Basel ( Unibas ), Dutch Institute for Fundamental Energy Research [Nieuwegein] ( DIFFER ), Dutch Institute for Fundamental Energy Research [Eindhoven] ( DIFFER ), Institut Jean Lamour ( IJL ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Lorraine ( UL ), Dipartimento di Energia, Politecnico di Milano [Milan], Max Planck Institute for Plasma Physics, Laboratoire de Mécanique, Modélisation et Procédés Propres ( M2P2 ), Aix Marseille Université ( AMU ) -Ecole Centrale de Marseille ( ECM ) -Centre National de la Recherche Scientifique ( CNRS ), Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. ANT - Advanced Nuclear Technologies Research Group, JET Contributors, Litaudon, X, Abduallev, S, Abhangi, M, Abreu, P, Afzal, M, Aggarwal, K, Ahlgren, T, Ahn, J, Aho Mantila, L, Aiba, N, Airila, M, Albanese, R, Aldred, V, Alegre, D, Alessi, E, Aleynikov, P, Alfier, A, Alkseev, A, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amicucci, L, Amosov, V, Andersson SundÃ©n, E, Angelone, M, Anghel, M, Angioni, C, Appel, L, Appelbee, C, Arena, P, Ariola, M, Arnichand, H, Arshad, S, Ash, A, Ashikawa, N, Aslanyan, V, Asunta, O, Auriemma, F, Austin, Y, Avotina, L, Axton, M, Ayres, C, Bacharis, M, Baciero, A, Baiã¡o, D, Bailey, S, Baker, A, Balboa, I, Balden, M, Balshaw, N, Bament, R, Banks, J, Baranov, Y, Barnard, M, Barnes, D, Barnes, M, Barnsley, R, Baron Wiechec, A, Barrera Orte, L, Baruzzo, M, Basiuk, V, Bassan, M, Bastow, R, Batista, A, Batistoni, P, Baughan, R, Bauvir, B, Baylor, L, Bazylev, B, Beal, J, Beaumont, P, Beckers, M, Beckett, B, Becoulet, A, Bekris, N, Beldishevski, M, Bell, K, Belli, F, Bellinger, M, Belonohy, Ã, Ben Ayed, N, Benterman, N, Bergsã¥ker, H, Bernardo, J, Bernert, M, Berry, M, Bertalot, L, Besliu, C, Beurskens, M, Bieg, B, Bielecki, J, Biewer, T, Bigi, M, Bãlkovã¡, P, Binda, F, Bisoffi, A, Bizarro, J, Bjã¶rkas, C, Blackburn, J, Blackman, K, Blackman, T, Blanchard, P, Blatchford, P, Bobkov, V, Boboc, A, Bodnã¡r, G, Bogar, O, Bolshakova, I, Bolzonella, T, Bonanomi, N, Bonelli, F, Boom, J, Booth, J, Borba, D, Borodin, D, Borodkina, I, Botrugno, A, Bottereau, C, Boulting, P, Bourdelle, C, Bowden, M, Bower, C, Bowman, C, Boyce, T, Boyd, C, Boyer, H, Bradshaw, J, Braic, V, Bravanec, R, Breizman, B, Bremond, S, Brennan, P, Breton, S, Brett, A, Brezinsek, S, Bright, M, Brix, M, Broeckx, W, Brombin, M, Broså‚awski, A, Brown, D, Brown, M, Bruno, E, Bucalossi, J, Buch, J, Buchanan, J, Buckley, M, Budny, R, Bufferand, H, Bulman, M, Bulmer, N, Bunting, P, Buratti, P, Burckhart, A, Buscarino, A, Busse, A, Butler, N, Bykov, I, Byrne, J, Cahyna, P, Calabrã², G, Calvo, I, Camenen, Y, Camp, P, Campling, D, Cane, J, Cannas, B, Capel, A, Card, P, Cardinali, A, Carman, P, Carr, M, Carralero, D, Carraro, L, Carvalho, B, Carvalho, I, Carvalho, P, Casson, F, Castaldo, C, Catarino, N, Caumont, J, Causa, F, Cavazzana, R, Cave Ayland, K, Cavinato, M, Cecconello, M, Ceccuzzi, S, Cecil, E, Cenedese, A, Cesario, R, Challis, C, Chandler, M, Chandra, D, Chang, C, Chankin, A, Chapman, I, Chapman, S, Chernyshova, M, Chitarin, G, Ciraolo, G, Ciric, D, Citrin, J, Clairet, F, Clark, E, Clark, M, Clarkson, R, Clatworthy, D, Clements, C, Cleverly, M, Coad, J, Coates, P, Cobalt, A, Coccorese, V, Cocilovo, V, Coda, S, Coelho, R, Coenen, J, Coffey, I, Colas, L, Collins, S, Conka, D, Conroy, S, Conway, N, Coombs, D, Cooper, D, Cooper, S, Corradino, C, Corre, Y, Corrigan, G, Cortes, S, Coster, D, Couchman, A, Cox, M, Craciunescu, T, Cramp, S, Craven, R, Crisanti, F, Croci, G, Croft, D, Crombã©, K, Crowe, R, Cruz, N, Cseh, G, Cufar, A, Cullen, A, Curuia, M, Czarnecka, A, Dabirikhah, H, Dalgliesh, P, Dalley, S, Dankowski, J, Darrow, D, Davies, O, Davis, W, Day, C, Day, I, De Bock, M, De Castro, A, De La Cal, E, De La Luna, E, De Masi, G, De Pablos, J, De Temmerman, G, De Tommasi, G, De Vries, P, Deakin, K, Deane, J, Degli Agostini, F, Dejarnac, R, Delabie, E, Den Harder, N, Dendy, R, Denis, J, Denner, P, Devaux, S, Devynck, P, Di Maio, F, Di Siena, A, Di Troia, C, Dinca, P, D'Inca, R, Ding, B, Dittmar, T, Doerk, H, Doerner, R, Donnã©, T, Dorling, S, Dormido Canto, S, Doswon, S, Douai, D, Doyle, P, Drenik, A, Drewelow, P, Drews, P, Duckworth, P, Dumont, R, Dumortier, P, Dunai, D, Dunne, M, Äžuran, I, Durodiã©, F, Dutta, P, Duval, B, Dux, R, Dylst, K, Dzysiuk, N, Edappala, P, Edmond, J, Edwards, A, Edwards, J, Eich, T, Ekedahl, A, El Jorf, R, Elsmore, C, Enachescu, M, Ericsson, G, Eriksson, F, Eriksson, J, Eriksson, L, Esposito, B, Esquembri, S, Esser, H, Esteve, D, Evans, B, Evans, G, Evison, G, Ewart, G, Fagan, D, Faitsch, M, Falie, D, Fanni, A, Fasoli, A, Faustin, J, Fawlk, N, Fazendeiro, L, Fedorczak, N, Felton, R, Fenton, K, Fernades, A, Fernandes, H, Ferreira, J, Fessey, J, Fã©vrier, O, Ficker, O, Field, A, Fietz, S, Figueiredo, A, Figueiredo, J, Fil, A, Finburg, P, Firdaouss, M, Fischer, U, Fittill, L, Fitzgerald, M, Flammini, D, Flanagan, J, Fleming, C, Flinders, K, Fonnesu, N, Fontdecaba, J, Formisano, A, Forsythe, L, Fortuna, L, Fortuna Zalesna, E, Fortune, M, Foster, S, Franke, T, Franklin, T, Frasca, M, Frassinetti, L, Freisinger, M, Fresa, R, Frigione, D, Fuchs, V, Fuller, D, Futatani, S, Fyvie, J, Gã¡l, K, Galassi, D, Gaå‚azka, K, Galdon Quiroga, J, Gallagher, J, Gallart, D, Galvã¡o, R, Gao, X, Gao, Y, Garcia, J, Garcia Carrasco, A, GarcÃa MuÃ±oz, M, Gardarein, J, Garzotti, L, Gaudio, P, Gauthier, E, Gear, D, Gee, S, Geiger, B, Gelfusa, M, Gerasimov, S, Gervasini, G, Gethins, M, Ghani, Z, Ghate, M, Gherendi, M, Giacalone, J, Giacomelli, L, Gibson, C, Giegerich, T, Gil, C, Gil, L, Gilligan, S, Gin, D, Giovannozzi, E, Girardo, J, Giroud, C, Giruzzi, G, Glã¶ggler, S, Godwin, J, Goff, J, Gohil, P, Goloborod'Ko, V, Gomes, R, Goncalves, B, Goniche, M, Goodliffe, M, Goodyear, A, Gorini, G, Gosk, M, Goulding, R, Goussarov, A, Gowland, R, Graham, B, Graham, M, Graves, J, Grazier, N, Grazier, P, Green, N, Greuner, H, Grierson, B, Griph, F, Grisolia, C, Grist, D, Groth, M, Grove, R, Grundy, C, Grzonka, J, Guard, D, Guã©rard, C, Guillemaut, C, Guirlet, R, Gurl, C, Utoh, H, Hackett, L, Hacquin, S, Hagar, A, Hager, R, Hakola, A, Halitovs, M, Hall, S, Hallworth Cook, S, Hamlyn Harris, C, Hammond, K, Harrington, C, Harrison, J, Harting, D, Hasenbeck, F, Hatano, Y, Hatch, D, Haupt, T, Hawes, J, Hawkes, N, Hawkins, J, Hawkins, P, Haydon, P, Hayter, N, Hazel, S, Heesterman, P, Heinola, K, Hellesen, C, Hellsten, T, Helou, W, Hemming, O, Hender, T, Henderson, M, Henderson, S, Henriques, R, Hepple, D, Hermon, G, Hertout, P, Hidalgo, C, Highcock, E, Hill, M, Hillairet, J, Hillesheim, J, Hillis, D, Hizanidis, K, Hjalmarsson, A, Hobirk, J, Hodille, E, Hogben, C, Hogeweij, G, Hollingsworth, A, Hollis, S, Homfray, D, Horã¡ä ek, J, Hornung, G, Horton, A, Horton, L, Horvath, L, Hotchin, S, Hough, M, Howarth, P, Hubbard, A, Huber, A, Huber, V, Huddleston, T, Hughes, M, Huijsmans, G, Hunter, C, Huynh, P, Hynes, A, Iglesias, D, Imazawa, N, Imbeaux, F, Imrãå¡ek, M, Incelli, M, Innocente, P, Irishkin, M, Ivanova Stanik, I, Jachmich, S, Jacobsen, A, Jacquet, P, Jansons, J, Jardin, A, Jã¤rvinen, A, Jaulmes, F, Jednorã³g, S, Jenkins, I, Jeong, C, Jepu, I, Joffrin, E, Johnson, R, Johnson, T, Johnston, J, Joita, L, Jones, G, Jones, T, Hoshino, K, Kallenbach, A, Kamiya, K, Kaniewski, J, Kantor, A, Kappatou, A, Karhunen, J, Karkinsky, D, Karnowska, I, Kaufman, M, Kaveney, G, Kazakov, Y, Kazantzidis, V, Keeling, D, Keenan, T, Keep, J, Kempenaars, M, Kennedy, C, Kenny, D, Kent, J, Kent, O, Khilkevich, E, Kim, H, Kinch, A, King, C, King, D, King, R, Kinna, D, Kiptily, V, Kirk, A, Kirov, K, Kirschner, A, Kizane, G, Klepper, C, Klix, A, Knight, P, Knipe, S, Knott, S, Kobuchi, T, Kã¶chl, F, Kocsis, G, Kodeli, I, Kogan, L, Kogut, D, Koivuranta, S, Kominis, Y, Kã¶ppen, M, Kos, B, Koskela, T, Koslowski, H, Koubiti, M, Kovari, M, Kowalska StrzÈ©ciwilk, E, Krasilnikov, A, Krasilnikov, V, Krawczyk, N, Kresina, M, Krieger, K, Krivska, A, Kruezi, U, Ksiaå¼ek, I, Kukushkin, A, Kundu, A, Kurki Suonio, T, Kwak, S, Kwiatkowski, R, Kwon, O, Laguardia, L, Lahtinen, A, Laing, A, Lam, N, Lambertz, H, Lane, C, Lang, P, Lanthaler, S, Lapins, J, Lasa, A, Last, J, Å aszyå„ska, E, Lawless, R, Lawson, A, Lawson, K, Lazaros, A, Lazzaro, E, Leddy, J, Lee, S, Lefebvre, X, Leggate, H, Lehmann, J, Lehnen, M, Leichtle, D, Leichuer, P, Leipold, F, Lengar, I, Lennholm, M, Lerche, E, Lescinskis, A, Lesnoj, S, Letellier, E, Leyland, M, Leysen, W, Li, L, Liang, Y, Likonen, J, Linke, J, Linsmeier, C, Lipschultz, B, Liu, G, Liu, Y, Lo Schiavo, V, Loarer, T, Loarte, A, Lobel, R, Lomanowski, B, Lomas, P, Lã¶nnroth, J, Lã³pez, J, LÃ³pez Razola, J, Lorenzini, R, Losada, U, Lovell, J, Loving, A, Lowry, C, Luce, T, Lucock, R, Lukin, A, Luna, C, Lungaroni, M, Lungu, C, Lungu, M, Lunniss, A, Lupelli, I, Lyssoivan, A, Macdonald, N, Macheta, P, Maczewa, K, Magesh, B, Maget, P, Maggi, C, Maier, H, Mailloux, J, Makkonen, T, Makwana, R, Malaquias, A, Malizia, A, Manas, P, Manning, A, Manso, M, Mantica, P, Mantsinen, M, Manzanares, A, Maquet, P, Marandet, Y, Marcenko, N, Marchetto, C, Marchuk, O, Marinelli, M, Marinucci, M, Markoviä , T, Marocco, D, Marot, L, Marren, C, Marshal, R, Martin, A, Martin, Y, MartÃn De Aguilera, A, Martãnez, F, MartÃn SolÃs, J, Martynova, Y, Maruyama, S, Masiello, A, Maslov, M, Matejcik, S, Mattei, M, Matthews, G, Maviglia, F, Mayer, M, Mayoral, M, May Smith, T, Mazon, D, Mazzotta, C, Mcadams, R, Mccarthy, P, Mcclements, K, Mccormack, O, Mccullen, P, Mcdonald, D, Mcintosh, S, Mckean, R, Mckehon, J, Meadows, R, Meakins, A, Medina, F, Medland, M, Medley, S, Meigh, S, Meigs, A, Meisl, G, Meitner, S, Meneses, L, Menmuir, S, Mergia, K, Merrigan, I, Mertens, P, Meshchaninov, S, Messiaen, A, Meyer, H, Mianowski, S, Michling, R, Middleton Gear, D, Miettunen, J, Militello, F, Militello Asp, E, Miloshevsky, G, Mink, F, Minucci, S, Miyoshi, Y, Mlynã¡å™, J, Molina, D, Monakhov, I, Moneti, M, Mooney, R, Moradi, S, Mordijck, S, Moreira, L, Moreno, R, Moro, F, Morris, A, Morris, J, Moser, L, Mosher, S, Moulton, D, Murari, A, Muraro, A, Murphy, S, Asakura, N, Na, Y, Nabais, F, Naish, R, Nakano, T, Nardon, E, Naulin, V, Nave, M, Nedzelski, I, Nemtsev, G, Nespoli, F, Neto, A, Neu, R, Neverov, V, Newman, M, Nicholls, K, Nicolas, T, Nielsen, A, Nielsen, P, Nilsson, E, Nishijima, D, Noble, C, Nocente, M, Nodwell, D, Nordlund, K, Nordman, H, Nouailletas, R, Nunes, I, Oberkofler, M, Odupitan, T, Ogawa, M, O'Gorman, T, Okabayashi, M, Olney, R, Omolayo, O, O'Mullane, M, Ongena, J, Orsitto, F, Orszagh, J, Oswuigwe, B, Otin, R, Owen, A, Paccagnella, R, Pace, N, Pacella, D, Packer, L, Page, A, Pajuste, E, Palazzo, S, Pamela, S, Panja, S, Papp, P, Paprok, R, Parail, V, Park, M, Parra Diaz, F, Parsons, M, Pasqualotto, R, Patel, A, Pathak, S, Paton, D, Patten, H, Pau, A, Pawelec, E, Paz Soldan, C, Peackoc, A, Pearson, I, Pehkonen, S, Peluso, E, Penot, C, Pereira, A, Pereira, R, Pereira Puglia, P, Perez Von Thun, C, Peruzzo, S, Peschanyi, S, Peterka, M, Petersson, P, Petravich, G, Petre, A, Petrella, N, Petrå¾ilka, V, Peysson, Y, Pfefferlã©, D, Philipps, V, Pillon, M, Pintsuk, G, Piovesan, P, Pires Dos Reis, A, Piron, L, Pironti, A, Pisano, F, Pitts, R, Pizzo, F, Plyusnin, V, Pomaro, N, Pompilian, O, Pool, P, Popovichev, S, Porfiri, M, Porosnicu, C, Porton, M, Possnert, G, Potzel, S, Powell, T, Pozzi, J, Prajapati, V, Prakash, R, Prestopino, G, Price, D, Price, M, Price, R, Prior, P, Proudfoot, R, Pucella, G, Puglia, P, Puiatti, M, Pulley, D, Purahoo, K, Pã¼tterich, T, Rachlew, E, Rack, M, Ragona, R, Rainford, M, Rakha, A, Ramogida, G, Ranjan, S, Rapson, C, 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D., Strachan, J., Strand, P., Strauss, H. R., Ström, P., Stubbs, G., Studholme, W., Subba, F., Summers, H. P., Svensson, J., Świderski, Ł., Szabolics, T., Szawlowski, M., Szepesi, G., Suzuki, T. T., Tál, B., Tala, T., Talbot, A. R., Talebzadeh, S., Taliercio, C., Tamain, P., Tame, C., Tang, W., Tardocchi, M., Taroni, L., Taylor, D., Taylor, K. A., Tegnered, D., Telesca, G., Teplova, N., Terranova, D., Testa, D., Tholerus, E., Thomas, J., Thomas, J. D., Thomas, P., Thompson, A., Thompson, C. -A., Thompson, V. K., Thorne, L., Thornton, A., Thrysøe, A. S., Tigwell, P. A., Tipton, N., Tiseanu, I., Tojo, H., Tokitani, M., Tolias, P., Tomeš, M., Tonner, P., Towndrow, M., Trimble, P., Tripsky, M., Tsalas, M., Tsavalas, P., Tskhakaya jun, D., Turner, I., Turner, M. M., Turnyanskiy, M., Tvalashvili, G., Tyrrell, S. G. J., Uccello, A., Ul-Abidin, Z., Uljanovs, J., Ulyatt, D., Urano, H., Uytdenhouwen, I., Vadgama, A. 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W., Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Hôpital de Rangueil, CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse], Laboratoire de microbiologie et génétique moléculaires (LMGM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Lorraine (UL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Energia [Milano] (DENG), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Research Centre Julich (FZJ), Institute for Plasma Research, Instituto Superior Tecnico Lisboa, Queen's University Belfast, University of Helsinki, CEA, Department of Applied Physics, School services, SCI, National Institutes for Quantum and Radiological Science and Technology, VTT, University of Naples Federico II, Universidad Nacional de Educacion a Distancia, CNR, Russian Research Centre Kurchatov Institute, Universita degli Studi di Napoli Parthenope, Ente Per Le Nuove Tecnologie L'energia e l'ambiente, Troitsk Institute for Innovation and Fusion Research, Uppsala University, National Institute for Cryogenics and Isotopic Technology, Max-Planck-Institut fur Plasmaphysik, University of Catania, Fusion for Energy Joint Undertaking, National Institutes of Natural Sciences - National Institute for Fusion Science, Massachusetts Institute of Technology, University of Latvia, Imperial College London, CIEMAT, University of Oxford, EUROfusion Programme Management Unit, Oak Ridge National Laboratory, Karlsruhe Institute of Technology KIT, University of York, Royal Institute of Technology, Maritime University of Szczecin, H. Niewodniczanski Institute of Nuclear Physics of the Polish Academy of Sciences, Czech Academy of Sciences, University of Trento, Ecole Polytechnique Federale de Lausanne (EPFL), Wigner Research Centre for Physics, Comenius University, University of Milan - Bicocca, National Institute for Optoelectronics, Fourth State Research, University of Texas at Austin, Belgian Nuclear Research Center, National Centre for Nuclear Research (NCBJ), Princeton University, CNRS, University of Cagliari, University of Warwick, Soltan Institute for Nuclear Studies, FOM Institute DIFFER, National Institute for Laser, Plasma and Radiation Physics, Ghent University, J. Stefan Institute, Universite de Lorraine, CAS - Institute of Plasma Physics, University of California at San Diego, Koninklijke Militaire School - Ecole Royale Militaire, Horia Hulubei National Institute of Physics and Nuclear Engineering, Chalmers University of Technology, School services, ELEC, Department of Signal Processing and Acoustics, Automaatio- ja systeemitekniik, Universidad Politecnica de Madrid, Second University of Naples, Warsaw University of Technology, Universita della Basilicata, Barcelona Supercomp. Center, Universidad de Sevilla, Centro Brasileiro de Pesquisas Fisicas, Department of Electrical Engineering and Automation, Sähkötekniikan laitos, University of Rome Tor Vergata, RAS - Ioffe Physico Technical Institute, General Atomics, University of Innsbruck, Fusion and Plasma Physics, University of Toyama, University of Strathclyde, National Technical University of Athens, Universita della Tuscia, Technical University of Denmark, Korea Advanced Institute of Science and Technology, Seoul National University, University College Cork, Vienna University of Technology, University of Opole, Daegu University, National Fusion Research Institute, Dublin City University, Universidad Politécnica de Madrid, PELIN LLC, Arizona State University, Universidad Complutense, University of Basel, Universidad Carlos III de Madrid, Consorzio CREATE, Demokritos National Centre for Scientific Research, Purdue University, Universite Libre de Bruxelles, School Services, ARTS, Department of Design, University of California Office of the President, Universidade de Sao Paulo, School Services, BIZ, Department of Information and Service Management, Lithuanian Energy Institute, HRS Fusion, Politecnico di Torino, University of Cassino, University of Electronic Science and Technology of China, Department of Electronics and Nanoengineering, Aalto-yliopisto, Aalto University, and Faculdade de Engenharia
Subjects: Technology, fusion, Física [Ciências exactas e naturais], Tokamak, Nuclear engineering, DIAGNOSTICS, 01 natural sciences, ILW, 010305 fluids & plasmas, law.invention, Ilw, [SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph], Plasma, H-Mode Plasmas, law, ITER, Disruption Prediction, COLLISIONALITY, EDGE LOCALIZED MODES, Diagnostics, Operation, JET, plasma, Nuclear and High Energy Physics, Condensed Matter Physics, Physics, Jet (fluid), JET, plasma, fusion, ITER, Divertor, Settore FIS/01 - Fisica Sperimentale, Fusion, Plasma and Space Physics, DENSITY PEAKING, Carbon Wall, H-MODE PLASMAS, [ SPI.MECA.MEFL ] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph], Density Peaking, Neutron transport, Facing Components, Collisionality, 114 Physical sciences, Física, Física, Nuclear physics, Physical sciences [Natural sciences], Fusion, plasma och rymdfysik, Pedestal, 0103 physical sciences, Nuclear fusion, ddc:530, Neutron, 010306 general physics, Fusion, Physics, Physical sciences, Nuclear and High Energy Physic, Edge Localized Modes, QC717, Física [Àrees temàtiques de la UPC], Reactors de fusió, Física, FACING COMPONENTS, Fusion reactors, Jet, CARBON WALL, DISRUPTION PREDICTION, OPERATION, ddc:600
Abstract: The 2014–2016 JET results are reviewed in the light of their significance for optimising the ITER research plan for the active and non-active operation. More than 60 h of plasma operation with ITER first wall materials successfully took place since its installation in 2011. New multi-machine scaling of the type I-ELM divertor energy flux density to ITER is supported by first principle modelling. ITER relevant disruption experiments and first principle modelling are reported with a set of three disruption mitigation valves mimicking the ITER setup. Insights of the L–H power threshold in Deuterium and Hydrogen are given, stressing the importance of the magnetic configurations and the recent measurements of fine-scale structures in the edge radial electric. Dimensionless scans of the core and pedestal confinement provide new information to elucidate the importance of the first wall material on the fusion performance. H-mode plasmas at ITER triangularity (H = 1 at ßN ~ 1.8 and n/nGW ~ 0.6) have been sustained at 2 MA during 5 s. The ITER neutronics codes have been validated on high performance experiments. Prospects for the coming D–T campaign and 14 MeV neutron calibration strategy are reviewed. This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 under grant agreement No 633053. Peer Reviewed Article signat per 1.173 autors/es: X. Litaudon35, S. Abduallev39, M. Abhangi46, P. Abreu53, M. Afzal7, K.M. Aggarwal29, T. Ahlgren101, J.H. Ahn8, L. Aho-Mantila112, N. Aiba69, M. Airila112, R. Albanese105, V. Aldred7, D. Alegre93, E. Alessi45, P. Aleynikov55, A. Alfier12, A. Alkseev72, M. Allinson7, B. Alper7, E. Alves53, G. Ambrosino105, R. Ambrosino106, L. Amicucci90, V. Amosov88, E. Andersson Sundén22, M. Angelone90, M. Anghel85, C. Angioni62, L. Appel7, C. Appelbee7, P. Arena30, M. Ariola106, H. Arnichand8, S. Arshad41, A. Ash7, N. Ashikawa68, V. Aslanyan64, O. Asunta1, F. Auriemma12, Y. Austin7, L. Avotina103, M.D. Axton7, C. Ayres7, M. Bacharis24, A. Baciero57, D. Baião53, S. Bailey7, A. Baker7, I. Balboa7, M. Balden62, N. Balshaw7, R. Bament7, J.W. Banks7, Y.F. Baranov7, M.A. Barnard7, D. Barnes7, M. Barnes27, R. Barnsley55, A. Baron Wiechec7, L. Barrera Orte34, M. Baruzzo12, V. Basiuk8, M. Bassan55, R. Bastow7, A. Batista53, P. Batistoni90, R. Baughan7, B. Bauvir55, L. Baylor73, B. Bazylev56, J. Beal110, P.S. Beaumont7, M. Beckers39, B. Beckett7, A. Becoulet8, N. Bekris35, M. Beldishevski7, K. Bell7, F. Belli90, M. Bellinger7, É. Belonohy62, N. Ben Ayed7, N.A. Benterman7, H. Bergsåker42, J. Bernardo53, M. Bernert62, M. Berry7, L. Bertalot55, C. Besliu7, M. Beurskens63, B. Bieg61, J. Bielecki47, T. Biewer73, M. Bigi12, P. Bílková50, F. Binda22, A. Bisoffi31, J.P.S. Bizarro53, C. Björkas101, J. Blackburn7, K. Blackman7, T.R. Blackman7, P. Blanchard33, P. Blatchford7, V. Bobkov62, A. Boboc7, G. Bodnár113, O. Bogar18, I. Bolshakova60, T. Bolzonella12, N. Bonanomi97, F. Bonelli56, J. Boom62, J. Booth7, D. Borba35,53, D. Borodin39, I. Borodkina39, A. Botrugno90, C. Bottereau8, P. Boulting7, C. Bourdelle8, M. Bowden7, C. Bower7, C. Bowman110, T. Boyce7, C. Boyd7, H.J. Boyer7, J.M.A. Bradshaw7, V. Braic87, R. Bravanec40, B. Breizman107, S. Bremond8, P.D. Brennan7, S. Breton8, A. Brett7, S. Brezinsek39, M.D.J. Bright7, M. Brix7, W. Broeckx78, M. Brombin12, A. Brosławski65, D.P.D. Brown7, M. Brown7, E. Bruno55, J. Bucalossi8, J. Buch46, J. Buchanan7, M.A. Buckley7, R. Budny76, H. Bufferand8, M. Bulman7, N. Bulmer7, P. Bunting7, P. Buratti90, A. Burckhart62, A. Buscarino30, A. Busse7, N.K. Butler7, I. Bykov42, J. Byrne7, P. Cahyna50, G. Calabrò90, I. Calvo57, Y. Camenen4, P. Camp7, D.C. Campling7, J. Cane7, B. Cannas17, A.J. Capel7, P.J. Card7, A. Cardinali90, P. Carman7, M. Carr7, D. Carralero62, L. Carraro12, B.B. Carvalho53, I. Carvalho53, P. Carvalho53, F.J. Casson7, C. Castaldo90, N. Catarino53, J. Caumont7, F. Causa90, R. Cavazzana12, K. Cave-Ayland7, M. Cavinato12, M. Cecconello22, S. Ceccuzzi90, E. Cecil76, A. Cenedese12, R. Cesario90, C.D. Challis7, M. Chandler7, D. Chandra46, C.S. Chang76, A. Chankin62, I.T. Chapman7, S.C. Chapman28, M. Chernyshova49, G. Chitarin12, G. Ciraolo8, D. Ciric7, J. Citrin38, F. Clairet8, E. Clark7, M. Clark7, R. Clarkson7, D. Clatworthy7, C. Clements7, M. Cleverly7, J.P. Coad7, P.A. Coates7, A. Cobalt7, V. Coccorese105, V. Cocilovo90, S. Coda33, R. Coelho53, J.W. Coenen39, I. Coffey29, L. Colas8, S. Collins7, D. Conka103, S. Conroy22, N. Conway7, D. Coombs7, D. Cooper7, S.R. Cooper7, C. Corradino30, Y. Corre8, G. Corrigan7, S. Cortes53, D. Coster62, A.S. Couchman7, M.P. Cox7, T. Craciunescu86, S. Cramp7, R. Craven7, F. Crisanti90, G. Croci97, D. Croft7, K. Crombé15, R. Crowe7, N. Cruz53, G. Cseh113, A. Cufar81, A. Cullen7, M. Curuia85, A. Czarnecka49, H. Dabirikhah7, P. Dalgliesh7, S. Dalley7, J. Dankowski47, D. Darrow76, O. Davies7, W. Davis55,76, C. Day56, I.E. Day7, M. De Bock55, A. de Castro57, E. de la Cal57, E. de la Luna57, G. De Masi12, J. L. de Pablos57, G. De Temmerman55, G. De Tommasi105, P. de Vries55, K. Deakin7, J. Deane7, F. Degli Agostini12, R. Dejarnac50, E. Delabie73, N. den Harder38, R.O. Dendy7, J. Denis8, P. Denner39, S. Devaux62,104, P. Devynck8, F. Di Maio55, A. Di Siena62, C. Di Troia90, P. Dinca86, R. D’Inca62, B. Ding51, T. Dittmar39, H. Doerk62, R.P. Doerner9, T. Donné34, S.E. Dorling7, S. Dormido-Canto93, S. Doswon7, D. Douai8, P.T. Doyle7, A. Drenik62,81, P. Drewelow63, P. Drews39, Ph. Duckworth55, R. Dumont8, P. Dumortier58, D. Dunai113, M. Dunne62, I. Ďuran50, F. Durodié58, P. Dutta46, B. P. Duval33, R. Dux62, K. Dylst78, N. Dzysiuk22, P.V. Edappala46, J. Edmond7, A.M. Edwards7, J. Edwards7, Th. Eich62, A. Ekedahl8, R. El-Jorf7, C.G. Elsmore7, M. Enachescu84, G. Ericsson22, F. Eriksson16, J. Eriksson22, L.G. Eriksson36, B. Esposito90, S. Esquembri94, H.G. Esser39, D. Esteve8, B. Evans7, G.E. Evans7, G. Evison7, G.D. Ewart7, D. Fagan7, M. Faitsch62, D. Falie86, A. Fanni17, A. Fasoli33, J. M. Faustin33, N. Fawlk7, L. Fazendeiro53, N. Fedorczak8, R.C. Felton7, K. Fenton7, A. Fernades53, H. Fernandes53, J. Ferreira53, J.A. Fessey7, O. Février8, O. Ficker50, A. Field7, S. Fietz62, A. Figueiredo53, J. Figueiredo53,35, A. Fil8, P. Finburg7, M. Firdaouss8, U. Fischer56, L. Fittill7, M. Fitzgerald7, D. Flammini90, J. Flanagan7, C. Fleming7, K. Flinders7, N. Fonnesu90, J. M. Fontdecaba57, A. Formisano79, L. Forsythe7, L. Fortuna30, E. Fortuna-Zalesna19, M. Fortune7, S. Foster7, T. Franke34, T. Franklin7, M. Frasca30, L. Frassinetti42, M. Freisinger39, R. Fresa98, D. Frigione90, V. Fuchs50, D. Fuller35, S. Futatani6, J. Fyvie7, K. Gál34,62, D. Galassi2, K. Gałązka49, J. Galdon-Quiroga92, J. Gallagher7, D. Gallart6, R. Galvão10, X. Gao51, Y. Gao39, J. Garcia8, A. Garcia-Carrasco42, M. García-Muñoz92, J.-L. Gardarein3, L. Garzotti7, P. Gaudio95, E. Gauthier8, D.F. Gear7, S.J. Gee7, B. Geiger62, M. Gelfusa95, S. Gerasimov7, G. Gervasini45, M. Gethins7, Z. Ghani7, M. Ghate46, M. Gherendi86, J.C. Giacalone8, L. Giacomelli45, C.S. Gibson7, T. Giegerich56, C. Gil8, L. Gil53, S. Gilligan7, D. Gin54, E. Giovannozzi90, J.B. Girardo8, C. Giroud7, G. Giruzzi8, S. Glöggler62, J. Godwin7, J. Goff7, P. Gohil43, V. Goloborod’ko102, R. Gomes53, B. Gonçalves53, M. Goniche8, M. Goodliffe7, A. Goodyear7, G. Gorini97, M. Gosk65, R. Goulding76, A. Goussarov78, R. Gowland7, B. Graham7, M.E. Graham7, J. P. Graves33, N. Grazier7, P. Grazier7, N.R. Green7, H. Greuner62, B. Grierson76, F.S. Griph7, C. Grisolia8, D. Grist7, M. Groth1, R. Grove73, C.N. Grundy7, J. Grzonka19, D. Guard7, C. Guérard34, C. Guillemaut8,53, R. Guirlet8, C. Gurl7, H.H. Utoh69, L.J. Hackett7, S. Hacquin8,35, A. Hagar7, R. Hager76, A. Hakola112, M. Halitovs103, S.J. Hall7, S.P. Hallworth Cook7, C. Hamlyn-Harris7, K. Hammond7, C. Harrington7, J. Harrison7, D. Harting7, F. Hasenbeck39, Y. Hatano108, D.R. Hatch107, T.D.V. Haupt7, J. Hawes7, N.C. Hawkes7, J. Hawkins7, P. Hawkins7, P.W. Haydon7, N. Hayter7, S. Hazel7, P.J.L. Heesterman7, K. Heinola101, C. Hellesen22, T. Hellsten42, W. Helou8, O.N. Hemming7, T.C. Hender7, M. Henderson55, S.S. Henderson21, R. Henriques53, D. Hepple7, G. Hermon7, P. Hertout8, C. Hidalgo57, E.G. Highcock27, M. Hill7, J. Hillairet8, J. Hillesheim7, D. Hillis73, K. Hizanidis70, A. Hjalmarsson22, J. Hobirk62, E. Hodille8, C.H.A. Hogben7, G.M.D. Hogeweij38, A. Hollingsworth7, S. Hollis7, D.A. Homfray7, J. Horáček50, G. Hornung15, A.R. Horton7, L.D. Horton36, L. Horvath110, S.P. Hotchin7, M.R. Hough7, P.J. Howarth7, A. Hubbard64, A. Huber39, V. Huber39, T.M. Huddleston7, M. Hughes7, G.T.A. Huijsmans55, C.L. Hunter7, P. Huynh8, A.M. Hynes7, D. Iglesias7, N. Imazawa69, F. Imbeaux8, M. Imríšek50, M. Incelli109, P. Innocente12, M. Irishkin8, I. Ivanova-Stanik49, S. Jachmich58,35, A.S. Jacobsen83, P. Jacquet7, J. Jansons103, A. Jardin8, A. Järvinen1, F. Jaulmes38, S. Jednoróg49, I. Jenkins7, C. Jeong20, I. Jepu86, E. Joffrin8, R. Johnson7, T. Johnson42, Jane Johnston7, L. Joita7, G. Jones7, T.T.C. Jones7, K.K. Hoshino69, A. Kallenbach62, K. Kamiya69, J. Kaniewski7, A. Kantor7, A. Kappatou62, J. Karhunen1, D. Karkinsky7, I. Karnowska7, M. Kaufman73, G. Kaveney7, Y. Kazakov58, V. Kazantzidis70, D.L. Keeling7, T. Keenan7, J. Keep7, M. Kempenaars7, C. Kennedy7, D. Kenny7, J. Kent7, O.N. Kent7, E. Khilkevich54, H.T. Kim35, H.S. Kim80, A. Kinch7, C. king7, D. King7, R.F. King7, D.J. Kinna7, V. Kiptily7, A. Kirk7, K. Kirov7, A. Kirschner39, G. Kizane103, C. Klepper73, A. Klix56, P. Knight7, S.J. Knipe7, S. Knott96, T. Kobuchi69, F. Köchl111, G. Kocsis113, I. Kodeli81, L. Kogan7, D. Kogut8, S. Koivuranta112, Y. Kominis70, M. Köppen39, B. Kos81, T. Koskela1, H.R. Koslowski39, M. Koubiti4, M. Kovari7, E. Kowalska-Strzęciwilk49, A. Krasilnikov88, V. Krasilnikov88, N. Krawczyk49, M. Kresina8, K. Krieger62, A. Krivska58, U. Kruezi7, I. Książek48, A. Kukushkin72, A. Kundu46, T. Kurki-Suonio1, S. Kwak20, R. Kwiatkowski65, O.J. Kwon13, L. Laguardia45, A. Lahtinen101, A. Laing7, N. Lam7, H.T. Lambertz39, C. Lane7, P.T. Lang62, S. Lanthaler33, J. Lapins103, A. Lasa101, J.R. Last7, E. Łaszyńska49, R. Lawless7, A. Lawson7, K.D. Lawson7, A. Lazaros70, E. Lazzaro45, J. Leddy110, S. Lee66, X. Lefebvre7, H.J. Leggate32, J. Lehmann7, M. Lehnen55, D. Leichtle41, P. Leichuer7, F. Leipold55,83, I. Lengar81, M. Lennholm36, E. Lerche58, A. Lescinskis103, S. Lesnoj7, E. Letellier7, M. Leyland110, W. Leysen78, L. Li39, Y. Liang39, J. Likonen112, J. Linke39, Ch. Linsmeier39, B. Lipschultz110, G. Liu55, Y. Liu51, V.P. Lo Schiavo105, T. Loarer8, A. Loarte55, R.C. Lobel7, B. Lomanowski1, P.J. Lomas7, J. Lönnroth1,35, J. M. López94, J. López-Razola57, R. Lorenzini12, U. Losada57, J.J. Lovell7, A.B. Loving7, C. Lowry36, T. Luce43, R.M.A. Lucock7, A. Lukin74, C. Luna5, M. Lungaroni95, C.P. Lungu86, M. Lungu86, A. Lunniss110, I. Lupelli7, A. Lyssoivan58, N. Macdonald7, P. Macheta7, K. Maczewa7, B. Magesh46, P. Maget8, C. Maggi7, H. Maier62, J. Mailloux7, T. Makkonen1, R. Makwana46, A. Malaquias53, A. Malizia95, P. Manas4, A. Manning7, M.E. Manso53, P. Mantica45, M. Mantsinen6, A. Manzanares91, Ph. Maquet55, Y. Marandet4, N. Marcenko88, C. Marchetto45, O. Marchuk39, M. Marinelli95, M. Marinucci90, T. Markovič50, D. Marocco90, L. Marot26, C.A. Marren7, R. Marshal7, A. Martin7, Y. Martin33, A. Martín de Aguilera57, F.J. Martínez93, J. R. Martín-Solís14, Y. Martynova39, S. Maruyama55, A. Masiello12, M. Maslov7, S. Matejcik18, M. Mattei79, G.F. Matthews7, F. Maviglia11, M. Mayer62, M.L. Mayoral34, T. May-Smith7, D. Mazon8, C. Mazzotta90, R. McAdams7, P.J. McCarthy96, K.G. McClements7, O. McCormack12, P.A. McCullen7, D. McDonald34, S. McIntosh7, R. McKean7, J. McKehon7, R.C. Meadows7, A. Meakins7, F. Medina57, M. Medland7, S. Medley7, S. Meigh7, A.G. Meigs7, G. Meisl62, S. Meitner73, L. Meneses53, S. Menmuir7,42, K. Mergia71, I.R. Merrigan7, Ph. Mertens39, S. Meshchaninov88, A. Messiaen58, H. Meyer7, S. Mianowski65, R. Michling55, D. Middleton-Gear7, J. Miettunen1, F. Militello7, E. Militello-Asp7, G. Miloshevsky77, F. Mink62, S. Minucci105, Y. Miyoshi69, J. Mlynář50, D. Molina8, I. Monakhov7, M. Moneti109, R. Mooney7, S. Moradi37, S. Mordijck43, L. Moreira7, R. Moreno57, F. Moro90, A.W. Morris7, J. Morris7, L. Moser26, S. Mosher73, D. Moulton7,1, A. Murari12,35, A. Muraro45, S. Murphy7, N.N. Asakura69, Y.S. Na80, F. Nabais53, R. Naish7, T. Nakano69, E. Nardon8, V. Naulin83, M.F.F. Nave53, I. Nedzelski53, G. Nemtsev88, F. Nespoli33, A. Neto41, R. Neu62, V.S. Neverov72, M. Newman7, K.J. Nicholls7, T. Nicolas33, A.H. Nielsen83, P. Nielsen12, E. Nilsson8, D. Nishijima99, C. Noble7, M. Nocente97, D. Nodwell7, K. Nordlund101, H. Nordman16, R. Nouailletas8, I. Nunes53, M. Oberkofler62, T. Odupitan7, M.T. Ogawa69, T. O’Gorman7, M. Okabayashi76, R. Olney7, O. Omolayo7, M. O’Mullane21, J. Ongena58, F. Orsitto11, J. Orszagh18, B.I. Oswuigwe7, R. Otin7, A. Owen7, R. Paccagnella12, N. Pace7, D. Pacella90, L.W. Packer7, A. Page7, E. Pajuste103, S. Palazzo30, S. Pamela7, S. Panja46, P. Papp18, R. Paprok50, V. Parail7, M. Park66, F. Parra Diaz27, M. Parsons73, R. Pasqualotto12, A. Patel7, S. Pathak46, D. Paton7, H. Patten33, A. Pau17, E. Pawelec48, C. Paz Soldan43, A. Peackoc36, I.J. Pearson7, S.-P. Pehkonen112, E. Peluso95, C. Penot55, A. Pereira57, R. Pereira53, P.P. Pereira Puglia7, C. Perez von Thun35,39, S. Peruzzo12, S. Peschanyi56, M. Peterka50, P. Petersson42, G. Petravich113, A. Petre84, N. Petrella7, V. Petržilka50, Y. Peysson8, D. Pfefferlé33, V. Philipps39, M. Pillon90, G. Pintsuk39, P. Piovesan12, A. Pires dos Reis52, L. Piron7, A. Pironti105, F. Pisano17, R. Pitts55, F. Pizzo79, V. Plyusnin53, N. Pomaro12, O.G. Pompilian86, P.J. Pool7, S. Popovichev7, M.T. Porfiri90, C. Porosnicu86, M. Porton7, G. Possnert22, S. Potzel62, T. Powell7, J. Pozzi7, V. Prajapati46, R. Prakash46, G. Prestopino95, D. Price7, M. Price7, R. Price7, P. Prior7, R. Proudfoot7, G. Pucella90, P. Puglia52, M.E. Puiatti12, D. Pulley7, K. Purahoo7, Th. Pütterich62, E. Rachlew25, M. Rack39, R. Ragona58, M.S.J. Rainford7, A. Rakha6, G. Ramogida90, S. Ranjan46, C.J. Rapson62, J.J. Rasmussen83, K. Rathod46, G. Rattá57, S. Ratynskaia82, G. Ravera90, C. Rayner7, M. Rebai97, D. Reece7, A. Reed7, D. Réfy113, B. Regan7, J. Regaña34, M. Reich62, N. Reid7, F. Reimold39, M. Reinhart34, M. Reinke110,73, D. Reiser39, D. Rendell7, C. Reux8, S.D.A. Reyes Cortes53, S. Reynolds7, V. Riccardo7, N. Richardson7, K. Riddle7, D. Rigamonti97, F.G. Rimini7, J. Risner73, M. Riva90, C. Roach7, R.J. Robins7, S.A. Robinson7, T. Robinson7, D.W. Robson7, R. Roccella55, R. Rodionov88, P. Rodrigues53, J. Rodriguez7, V. Rohde62, F. Romanelli90, M. Romanelli7, S. Romanelli7, J. Romazanov39, S. Rowe7, M. Rubel42, G. Rubinacci105, G. 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Sommariva8, P. Sonato12, A. Sopplesa12, J. Sousa53, C. Sozzi45, S. Spagnolo12, T. Spelzini7, F. Spineanu86, G. Stables7, I. Stamatelatos71, M.F. Stamp7, P. Staniec7, G. Stankūnas59, C. Stan-Sion84, M.J. Stead7, E. Stefanikova42, I. Stepanov58, A.V. Stephen7, M. Stephen46, A. Stevens7, B.D. Stevens7, J. Strachan76, P. Strand16, H.R. Strauss44, P. Ström42, G. Stubbs7, W. Studholme7, F. Subba75, H.P. Summers21, J. Svensson63, Ł. Świderski65, T. Szabolics113, M. Szawlowski49, G. Szepesi7, T.T. Suzuki69, B. Tál113, T. Tala112, A.R. Talbot7, S. Talebzadeh95, C. Taliercio12, P. Tamain8, C. Tame7, W. Tang76, M. Tardocchi45, L. Taroni12, D. Taylor7, K.A. Taylor7, D. Tegnered16, G. Telesca15, N. Teplova54, D. Terranova12, D. Testa33, E. Tholerus42, J. Thomas7, J.D. Thomas7, P. Thomas55, A. Thompson7, C.-A. Thompson7, V.K. Thompson7, L. Thorne7, A. Thornton7, A.S. Thrysøe83, P.A. Tigwell7, N. Tipton7, I. Tiseanu86, H. Tojo69, M. Tokitani67, P. Tolias82, M. Tomeš50, P. Tonner7, M. Towndrow7, P. Trimble7, M. Tripsky58, M. Tsalas38, P. Tsavalas71, D. Tskhakaya jun102, I. Turner7, M.M. Turner32, M. Turnyanskiy34, G. Tvalashvili7, S.G.J. Tyrrell7, A. Uccello45, Z. Ul-Abidin7, J. Uljanovs1, D. Ulyatt7, H. Urano69, I. Uytdenhouwen78, A.P. Vadgama7, D. Valcarcel7, M. Valentinuzzi8, M. Valisa12, P. Vallejos Olivares42, M. Valovic7, M. Van De Mortel7, D. Van Eester58, W. Van Renterghem78, G.J. van Rooij38, J. Varje1, S. Varoutis56, S. Vartanian8, K. Vasava46, T. Vasilopoulou71, J. Vega57, G. Verdoolaege58, R. Verhoeven7, C. Verona95, G. Verona Rinati95, E. Veshchev55, N. Vianello45, J. Vicente53, E. Viezzer62,92, S. Villari90, F. Villone100, P. Vincenzi12, I. Vinyar74, B. Viola90, A. Vitins103, Z. Vizvary7, M. Vlad86, I. Voitsekhovitch34, P. Vondráček50, N. Vora7, T. Vu8, W.W. Pires de Sa52, B. Wakeling7, C.W.F. Waldon7, N. Walkden7, M. Walker7, R. Walker7, M. Walsh55, E. Wang39, N. Wang39, S. Warder7, R.J. Warren7, J. Waterhouse7, N.W. Watkins28, C. Watts55, T. Wauters58, A. Weckmann42, J. Weiland23, H. Weisen33, M. Weiszflog22, C. Wellstood7, A.T. West7, M.R. Wheatley7, S. Whetham7, A.M. Whitehead7, B.D. Whitehead7, A.M. Widdowson7, S. Wiesen39, J. Wilkinson7, J. Williams7, M. Williams7, A.R. Wilson7, D.J. Wilson7, H.R. Wilson110, J. Wilson7, M. Wischmeier62, G. Withenshaw7, A. Withycombe7, D.M. Witts7, D. Wood7, R. Wood7, C. Woodley7, S. Wray7, J. Wright7, J.C. Wright64, J. Wu89, S. Wukitch64, A. Wynn110, T. Xu7, D. Yadikin16, W. Yanling39, L. Yao89, V. Yavorskij102, M.G. Yoo80, C. Young7, D. Young7, I.D. Young7, R. Young7, J. Zacks7, R. Zagorski49, F.S. Zaitsev18, R. Zanino75, A. Zarins103, K.D. Zastrow7, M. Zerbini90, W. Zhang62, Y. Zhou42, E. Zilli12, V. Zoita86, S. Zoletnik113, I. Zychor65 and JET Contributorsa // EUROfusion Consortium JET, Culham Science Centre, Abingdon, OX14 3DB, United Kingdom / 1 Aalto University, PO Box 14100, FIN-00076 Aalto, Finland / 2 Aix Marseille Université, CNRS, Centrale Marseille, M2P2 UMR 7340, 13451, Marseille, France / 3 Aix-Marseille Université, CNRS, IUSTI UMR 7343, 13013 Marseille, France / 4 Aix-Marseille Université, CNRS, PIIM, UMR 7345, 13013 Marseille, France / 5 Arizona State University, Tempe, AZ, United States of America / 6 Barcelona Supercomputing Center, Barcelona, Spain / 7 CCFE, Culham Science Centre, Abingdon, Oxon, OX14 3DB, United Kingdom / 8 CEA, IRFM, F-13108 Saint Paul Lez Durance, France / 9 Center for Energy Research, University of California at San Diego, La Jolla, CA 92093, United States of America / 10 Centro Brasileiro de Pesquisas Fisicas, Rua Xavier Sigaud, 160, Rio de Janeiro CEP 22290-180, Brazil / 11 Consorzio CREATE, Via Claudio 21, 80125 Napoli, Italy / 12 Consorzio RFX, corso Stati Uniti 4, 35127 Padova, Italy / 13 Daegu University, Jillyang, Gyeongsan, Gyeongbuk 712-174, Republic of Korea / 14 Departamento de Física, Universidad Carlos III de Madrid, 28911 Leganés, Madrid, Spain / 15 Department of Applied Physics UG (Ghent University) St-Pietersnieuwstraat 41 B-9000 Ghent, Belgium / 16 Department of Earth and Space Sciences, Chalmers University of Technology, SE-41296 Gothenburg, Sweden / 17 Department of Electrical and Electronic Engineering, University of Cagliari, Piazza d’Armi 09123, Cagliari, Italy / 18 Department of Experimental Physics, Faculty of Mathematics, Physics and Informatics Comenius University Mlynska dolina F2, 84248 Bratislava, Slovakia / 19 Department of Materials Science, Warsaw University of Technology, PL-01-152 Warsaw, Poland / 20 Department of Nuclear and Quantum Engineering, KAIST, Daejeon 34141, Korea / 21 Department of Physics and Applied Physics, University of Strathclyde, Glasgow, G4 ONG, United Kingdom / 22 Department of Physics and Astronomy, Uppsala University, SE-75120 Uppsala, Sweden / 23 Department of Physics, Chalmers University of Technology, SE-41296 Gothenburg, Sweden / 24 Department of Physics, Imperial College London, London, SW7 2AZ, United Kingdom / 25 Department of Physics, SCI, KTH, SE-10691 Stockholm, Sweden / 26 Department of Physics, University of Basel, Basel, Switzerland / 27 Department of Physics, University of Oxford, Oxford, OX1 2JD, United Kingdom / 28 Department of Physics, University of Warwick, Coventry, CV4 7AL, United Kingdom / 29 Department of Pure and Applied Physics, Queens University, Belfast, BT7 1NN, United Kingdom / 30 Dipartimento di Ingegneria Elettrica Elettronica e Informatica, Università degli Studi di Catania, 95125 Catania, Italy / 31 Dipartimento di Ingegneria Industriale, University of Trento, Trento, Italy / 32 Dublin City University (DCU), Dublin, Ireland / 33 Ecole Polytechnique Fédérale de Lausanne (EPFL), Swiss Plasma Center (SPC), CH-1015 Lausanne, Switzerland / 34 EUROfusion Programme Management Unit, Boltzmannstr. 2, 85748 Garching, Germany / 35 EUROfusion Programme Management Unit, Culham Science Centre, Culham, OX14 3DB, United Kingdom / 36 European Commission, B-1049 Brussels, Belgium / 37 Fluid and Plasma Dynamics, ULB—Campus Plaine—CP 231 Boulevard du Triomphe, 1050 Bruxelles, Belgium / 38 FOM Institute DIFFER, Eindhoven, Netherlands / 39 Forschungszentrum Jülich GmbH, Institut für Energie- und Klimaforschung—Plasmaphysik, 52425 Jülich, Germany / 40 Fourth State Research, 503 Lockhart Dr, Austin, TX, United States of America / 41 Fusion for Energy Joint Undertaking, Josep Pl. 2, Torres Diagonal Litoral B3, 08019, Barcelona, Spain / 42 Fusion Plasma Physics, EES, KTH, SE-10044 Stockholm, Sweden / 43 General Atomics, PO Box 85608, San Diego, CA 92186-5608, United States of America / 44 HRS Fusion, West Orange, NJ, United States of America / 45 IFP-CNR, via R. Cozzi 53, 20125 Milano, Italy / 46 Institute for Plasma Research, Bhat, Gandhinagar-382 428, Gujarat State, India / 47 Institute of Nuclear Physics, Radzikowskiego 152, 31-342 Kraków, Poland / 48 Institute of Physics, Opole University, Oleska 48, 45-052 Opole, Poland / 49 Institute of Plasma Physics and Laser Microfusion, Hery 23, 01-497 Warsaw, Poland / 50 Institute of Plasma Physics AS CR, Za Slovankou 1782/3, 182 00 Praha 8, Czechia / 51 Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031, People’s Republic of China / 52 Instituto de Física, Universidade de São Paulo, Rua do Matão Travessa R Nr.187 CEP 05508-090 Cidade Universitária, São Paulo, Brasil / 53 Instituto de Plasmas e Fusão Nuclear, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal / 54 Ioffe Physico-Technical Institute, 26 Politekhnicheskaya, St Petersburg 194021, Russian Federation / 55 ITER Organization, Route de Vinon, CS 90 046, 13067 Saint Paul Lez Durance, France / 56 Karlsruhe Institute of Technology, PO Box 3640, D-76021 Karlsruhe, Germany / 57 Laboratorio Nacional de Fusión, CIEMAT, Madrid, Spain / 58 Laboratory for Plasma Physics Koninklijke Militaire School—Ecole Royale Militaire, Renaissancelaan 30 Avenue de la Renaissance B-1000, Brussels, Belgium / 59 Lithuanian energy institute, Breslaujos g. 3, LT-44403, Kaunas, Lithuania / 60 Magnetic Sensor Laboratory, Lviv Polytechnic National University, Lviv, Ukraine / 61 Maritime University of Szczecin, Waly Chrobrego 1-2, 70-500 Szczecin, Poland / 62 Max-Planck-Institut für Plasmaphysik, D-85748 Garching, Germany / 63 Max-Planck-Institut für Plasmaphysik, Teilinsitut Greifswald, D-17491 Greifswald, Germany / 64 MIT Plasma Science and Fusion Centre, Cambridge, MA 02139, United States of America / 65 National Centre for Nuclear Research (NCBJ), 05-400 Otwock-Świerk, Poland / 66 National Fusion Research Institute (NFRI), 169-148 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea / 67 National Institute for Fusion Science, Oroshi, Toki, Gifu 509-5292, Japan / 68 National Institute for Fusion Science, Toki, 509-5292, Japan / 69 National Institutes for Quantum and Radiological Science and Technology, Naka, Ibaraki 311-0193, Japan / 70 National Technical University of Athens, Iroon Politechniou 9, 157 73 Zografou, Athens, Greece / 71 NCSR ‘Demokritos’, 153 10, Agia Paraskevi Attikis, Greece / 72 NRC Kurchatov Institute, 1 Kurchatov Square, Moscow 123182, Russian Federation / 73 Oak Ridge National Laboratory, Oak Ridge, TN 37831-6169, United States of America / 74 PELIN LLC, 27a, Gzhatskaya Ulitsa, Saint Petersburg, 195220, Russian Federation / 75 Politecnico di Torino, Corso Duca degli Abruzzi 24, I-10129 Torino, Italy / 76 Princeton Plasma Physics Laboratory, James Forrestal Campus, Princeton, NJ 08543, United States of America / 77 Purdue University, 610 Purdue Mall, West Lafayette, IN 47907, United States of America / 78 SCK-CEN, Nuclear Research Centre, 2400 Mol, Belgium / 79 Second University of Napoli, Consorzio CREATE, Via Claudio 21, 80125 Napoli, Italy / 80 Seoul National University, Shilim-Dong, Gwanak-Gu, Republic of Korea / 81 Slovenian Fusion Association (SFA), Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia / 82 Space and Plasma Physics, EES, KTH SE-100 44 Stockholm, Sweden / 83 Technical University of Denmark, Department of Physics, Bldg 309, DK-2800 Kgs Lyngby, Denmark / 84 The ‘Horia Hulubei’ National Institute for Physics and Nuclear Engineering, Magurele-Bucharest, Romania / 85 The National Institute for Cryogenics and Isotopic Technology, Ramnicu Valcea, Romania / 86 The National Institute for Laser, Plasma and Radiation Physics, Magurele-Bucharest, Romania / 87 The National Institute for Optoelectronics, Magurele-Bucharest, Romania / 88 Troitsk Insitute of Innovating and Thermonuclear Research (TRINITI), Troitsk 142190, Moscow Region, Russian Federation / 89 University of Electronic Science and Technology of China, Chengdu, People’s Republic of China / 90 Unità Tecnica Fusione, ENEA C. R. Frascati, via E. Fermi 45, 00044 Frascati (Roma), Italy / 91 Universidad Complutense de Madrid, Madrid, Spain / 92 Universidad de Sevilla, Sevilla, Spain / 93 Universidad Nacional de Educación a Distancia, Madrid, Spain / 94 Universidad Politécnica de Madrid, Grupo I2A2, Madrid, Spain / 95 Università di Roma Tor Vergata, Via del Politecnico 1, Roma, Italy / 96 University College Cork (UCC), Ireland / 97 University Milano-Bicocca, piazza della Scienza 3, 20126 Milano, Italy / 98 University of Basilicata, Consorzio CREATE, Via Claudio 21, 80125 Napoli, Italy / 99 University of California, 1111 Franklin St., Oakland, CA 94607, United States of America / 100 University of Cassino, Consorzio CREATE, Via Claudio 21, 80125 Napoli, Italy / 101 University of Helsinki, PO Box 43, FI-00014 University of Helsinki, Finland / 102 University of Innsbruck, Fusion@Österreichische Akademie der Wissenschaften (ÖAW), Innsbruck, Austria / 103 University of Latvia, 19 Raina Blvd., Riga, LV 1586, Latvia / 104 University of Lorraine, CNRS, UMR7198, YIJL, Nancy, France / 105 University of Napoli ‘Federico II’, Consorzio CREATE, Via Claudio 21, 80125 Napoli, Italy / 106 University of Napoli Parthenope, Consorzio CREATE, Via Claudio 21, 80125 Napoli, Italy / 107 University of Texas at Austin, Institute for Fusion Studies, Austin, TX 78712, United States of America / 108 University of Toyama, Toyama, 930-8555, Japan / 109 University of Tuscia, DEIM, Via del Paradiso 47, 01100 Viterbo, Italy / 110 University of York, Heslington, York YO10 5DD, United Kingdom / 111 Vienna University of Technology, Fusion@Österreichische Akademie der Wissenschaften (ÖAW), Austria / 112 VTT Technical Research Centre of Finland, PO Box 1000, FIN-02044 VTT, Finland / 113 Wigner Research Centre for Physics, PO Box 49, H-1525 Budapest, Hungary
Published: 2017
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9. Ecosystem-based fisheries management requires a change to the selective fishing philosophy

Author: Peter Bayliss, André E. Punt, Elizabeth A. Fulton, Mark T. Gibbs, Sean Pascoe, Anthony J. Richardson, Shijie Zhou, Keith Sainsbury, Anthony D. M. Smith, and Catherine M. Bulman
Subjects: 0106 biological sciences, Male, Fishing, Population Dynamics, Biodiversity, Fisheries, 010603 evolutionary biology, 01 natural sciences, Animals, Marine ecosystem, Ecosystem, 14. Life underwater, Fisheries science, Multidisciplinary, 010604 marine biology & hydrobiology, Fishes, 15. Life on land, Bycatch, Fishery, Sustainability, Perspective, Female, Fisheries management, Business, Seasons
Abstract: Globally, many fish species are overexploited, and many stocks have collapsed. This crisis, along with increasing concerns over flow-on effects on ecosystems, has caused a reevaluation of traditional fisheries management practices, and a new ecosystem-based fisheries management (EBFM) paradigm has emerged. As part of this approach, selective fishing is widely encouraged in the belief that nonselective fishing has many adverse impacts. In particular, incidental bycatch is seen as wasteful and a negative feature of fishing, and methods to reduce bycatch are implemented in many fisheries. However, recent advances in fishery science and ecology suggest that a selective approach may also result in undesirable impacts both to fisheries and marine ecosystems. Selective fishing applies one or more of the “6-S” selections: species, stock, size, sex, season, and space. However, selective fishing alters biodiversity, which in turn changes ecosystem functioning and may affect fisheries production, hindering rather than helping achieve the goals of EBFM. We argue here that a “balanced exploitation” approach might alleviate many of the ecological effects of fishing by avoiding intensive removal of particular components of the ecosystem, while still supporting sustainable fisheries. This concept may require reducing exploitation rates on certain target species or groups to protect vulnerable components of the ecosystem. Benefits to society could be maintained or even increased because a greater proportion of the entire suite of harvested species is used.
Published: 2010

10. Response to correspondence on 'Phenocopies in BRCA1 and BRCA2 families: evidence for modifier genes and implications for screening'

Author: Emma R. Woodward, A Shenton, Anthony Moran, D G R Evans, M Bulman, R Iddenden, F Lalloo, Adrian Smith, Eamonn R. Maher, Marie Boyd, and Lorraine P. Smith
Subjects: Genetics, Phenocopy, Mutation (genetic algorithm), Correspondence, Retrospective analysis, Large series, Biology, Gene, humanities, Genetics (clinical), Modifier Genes
Abstract: We wish to reply to the interesting comments concerning our paper on phenocopies in families positive for mutations in BRCA1/2 genes since its electronic publication in October 2006.1 We understand the reservations about changing practice in reassuring individuals who test negative for a family mutation based on one largely retrospective analysis of families, and clearly there is a need to confirm our results in other large series. We were particularly careful to obviate …
Published: 2007

11. Clinical assessment of the fetal right Quantitative Lung Index.

Author: Kontopoulos E, Bulman M, Gordienko I, Rodriguez MJ, Gallardo M, Copado Y, Acevedo S, Quintero L, and Quintero RA
Subjects: Infant, Newborn, Humans, Female, Pregnancy, Reproducibility of Results, Retrospective Studies, Prenatal Diagnosis, Lung diagnostic imaging, Lung abnormalities, Ultrasonography, Prenatal, Perinatal Death, Hernias, Diaphragmatic, Congenital diagnostic imaging, Hernias, Diaphragmatic, Congenital surgery, Fetal Diseases
Abstract: Objectives: We have previously described gestational-age-independent sonographic indices to assess fetal lung size in the right and left lungs: The Quantitative Lung Index for the right lung (QLI-R) and for the left lung (QLI-L), respectively. The purpose of this study was to evaluate the clinical cutoff point of the QLI-R to predict pulmonary hypoplasia and neonatal death., Materials and Methods: Retrospective assessment of the QLI-R in patients with left-sided congenital diaphragmatic hernia (CDH-L) and other fetal conditions at risk for fetal pulmonary hypoplasia. Cross-section and longitudinal assessment of the behavior of the QLI-R in untreated and treated patients. ROC curve analysis to determine the optimal cutoff point of the QLI-R in predicting neonatal death., Results: One hundred eighteen patients with CDH-L and other fetal conditions at risk for pulmonary hypoplasia had QLI-R measurements done. Seventeen patients were excluded for various reasons. Eleven patients with conditions other than CDH-L but at risk for pulmonary hypoplasia were used for intraclass coefficient measurements of the QLI-R. Ninety patients had CDH-L, of which 78 did not undergo antenatal intervention and in which the cutoff point for pulmonary hypoplasia and neonatal demise was assessed. Stent tracheal occlusion was performed in the remaining 12 patients with CDH-L, in which the behavior of the QLI after surgery was assessed. Analysis of the ICC showed an overall intra-rater reliability of 0.985 (Cronbach's Alpha-based). There was no correlation between gestational age and QLI-R (-0.73, Pearson correlation, p = .72). Twenty-six of the 78 patients (33%) with CDH-L managed expectantly had a neonatal demise. A QLI-R equal to or less than 0.45 was significantly predictive of neonatal demise (area under the curve 0.64, p = .046, sensitivity 77%). Nine of the 12 patients (75%) that underwent tracheal occlusion had neonatal survival. Of these, 10 had serial assessments of the QLI-R after surgery. An increase in the QLI-R of 0.11 was associated with a tendency for neonatal survival ( p = .056)., Conclusion: Our study confirms that the QLI-R is a gestational-age-independent measurement of fetal lung size, with a high degree of reproducibility. In a population of expectantly managed CDH-L patients, a cutoff value of the QLI-R of 0.45 or lower is predictive of neonatal death from pulmonary hypoplasia. The QLI-R can be used to monitor fetal lung growth after tracheal occlusion, and an increase in the QLI-R is suggestive of neonatal survival. Further prospective studies are needed to confirm these findings and to explore the use of the QLI in other populations at risk for pulmonary hypoplasia and consequent neonatal demise.
Published: 2023
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12. Predicting the likelihood of a BRCA1/2 pathogenic variant being somatic by testing only tumour DNA in non-mucinous high-grade epithelial ovarian cancer.

Author: Morgan RD, Burghel GJ, Flaum N, Bulman M, Smith P, Clamp AR, Hasan J, Mitchell C, Salih Z, Woodward ER, Lalloo F, Shaw J, Desai S, Crosbie EJ, Edmondson RJ, Schlecht H, Wallace AJ, Jayson GC, and Evans DGR
Subjects: Humans, Female, Carcinoma, Ovarian Epithelial genetics, Genetic Testing, BRCA2 Protein genetics, Germ-Line Mutation, DNA, Neoplasm, BRCA1 Protein genetics, Ovarian Neoplasms diagnosis, Ovarian Neoplasms genetics
Abstract: Aims: Clinical guidelines recommend testing both germline and tumour DNA for BRCA1/2 pathogenic variants (PVs) in non-mucinous high-grade epithelial ovarian cancer (NMEOC). In this study, we show that some tumour BRCA1/2 PVs are highly likely to be somatic based on certain clinical and variant characteristics, meaning it may not be necessary to test all NMEOC cases for germline BRCA1/2 PVs., Methods: An observational study that included all tumour BRCA1/2 PVs detected in cases of NMEOC in the Northwest of England between July 2017 and February 2022. All tumour BRCA1/2 PVs were compared with PVs recorded in a prospectively gathered pan-cancer germline BRCA1/2 (g BRCA ) testing database for the same geographical region (g BRCA1 PVs=910 and g BRCA2 PVs=922). Tumour BRCA1/2 PVs were categorised as common (≥1%), uncommon (<1%) or absent from the germline database., Results: One hundred and thirteen tumour BRCA1/2 PVs were detected in 111 NMEOC cases. There were 69 germline and 44 somatic variants. The mean age at diagnosis for g BRCA and somatic BRCA1/2 (s BRCA ) PVs was 56.9 and 68.5 years, respectively (Student's t-test p<0.0001). All s BRCA PVs were detected in non-familial cases. All tumour BRCA1/2 PVs with a variant allele frequency (VAF) <35% in non-familial cases were somatic variants. Eighty-one per cent of germline-tumour BRCA1/2 PVs were present (common=31, uncommon=25) in the g BRCA testing database, while 89% of somatic-tumour BRCA1/2 PVs were absent (n=39)., Conclusions: We predict the likelihood of a tumour BRCA1/2 PV being somatic is 99.8% in non-familial cases of NMEOC diagnosed aged ≥75, where the VAF is ≤30% and there is no regional germline commonality., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
Published: 2023
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13. Is Reflex Germline BRCA1/2 Testing Necessary in Women Diagnosed with Non-Mucinous High-Grade Epithelial Ovarian Cancer Aged 80 Years or Older?

Author: Morgan RD, Burghel GJ, Flaum N, Bulman M, Smith P, Clamp AR, Hasan J, Mitchell CL, Salih Z, Woodward ER, Lalloo F, Crosbie EJ, Edmondson RJ, Schlecht H, Jayson GC, and Evans DGR
Abstract: Women diagnosed with non-mucinous high-grade epithelial ovarian cancer (EOC) in England are often reflex-tested for germline and tumour BRCA1 / 2 variants. The value of germline BRCA1/2 testing in women diagnosed aged ≥80 is questionable. We performed an observational study of all women diagnosed with non-mucinous high-grade EOC who underwent germline and tumour BRCA1/2 testing by the North West of England Genomic Laboratory Hub. A subgroup of women also underwent germline testing using a panel of homologous recombination repair (HRR) genes and/or tumour testing for homologous recombination deficiency (HRD) using Myriad's myChoice® companion diagnostic. Seven-hundred-two patients successfully underwent both germline and tumour BRCA1/2 testing. Of these, 48 were diagnosed with non-mucinous high-grade EOC aged ≥80. In this age group, somatic BRCA1/2 pathogenic/likely pathogenic variants (PV/LPVs) were detected nine times more often than germline BRCA1/2 PV/LPVs. The only germline PV reported in a patient aged ≥80 was detected in germline and tumour DNA ( BRCA2 c.4478_4481del). No patient aged ≥80 had a germline PV/LPVs in a non- BRCA1/2 HRR gene. Thirty-eight percent of patients aged ≥80 had a tumour positive for HRD. Our data suggest that tumour BRCA1/2 and HRD testing is adequate for patients diagnosed with non-mucinous high-grade EOC aged ≥80, with germline BRCA1/2 testing reserved for women with a tumour BRCA1/2 PV/LPVs.
Published: 2023
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14. BRCA1/2 in non-mucinous epithelial ovarian cancer: tumour with or without germline testing?

Author: Morgan RD, Burghel GJ, Flaum N, Bulman M, Smith P, Clamp AR, Hasan J, Mitchell CL, Salih Z, Woodward ER, Lalloo F, Crosbie EJ, Edmondson RJ, Wallace AJ, Jayson GC, and Evans DGR
Subjects: Aged, BRCA1 Protein genetics, BRCA2 Protein genetics, Carcinoma, Ovarian Epithelial genetics, Female, Genetic Testing, Germ Cells, Humans, Germ-Line Mutation, Ovarian Neoplasms genetics
Abstract: National guidelines recommend testing all cases of non-mucinous epithelial ovarian cancer (NMEOC) for germline (blood) and somatic (tumour) BRCA1/2 pathogenic variants (PVs). We performed paired germline and somatic BRCA1/2 testing in consecutive cases of NMEOC (n = 388) to validate guidelines. Thirty-four somatic BRCA1/2 (sBRCA) PVs (9.7%) were detected in 350 cases with germline BRCA1/2 (gBRCA) wild-type. All sBRCA PVs were detected in non-familial cases. By analysing our regional germline BRCA1/2 database there were 92/1114 (8.3%) gBRCA PVs detected in non-familial cases (only 3% ≥70 years old) and 245/641 (38.2%) in familial cases. Germline non-familial cases were dominated by BRCA2 in older women (8/271 ≥ 70 years old, all BRCA2). The ratio of sBRCA-to-gBRCA was ≤1.0 in women aged <70 years old, compared to 5.2 in women aged ≥70 years old (P = 0.005). The likelihood of missed germline BRCA1/2 PVs (copy-number variants missed on most somatic assays) by testing only tumour DNA was 0.4% in women aged ≥70 years old. We recommend reflex tumour BRCA1/2 testing in all NMEOC cases, and that gBRCA testing is not required for women aged ≥70 years old with no identifiable tumour BRCA1/2 PV and/or family history of breast, ovarian, prostate and/or pancreatic cancer., (© 2022. Crown.)
Published: 2022
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15. 30 year experience of index case identification and outcomes of cascade testing in high-risk breast and colorectal cancer predisposition genes.

Author: Woodward ER, Green K, Burghel GJ, Bulman M, Clancy T, Lalloo F, Schlecht H, Wallace AJ, and Evans DG
Subjects: DNA Mismatch Repair genetics, Genes, BRCA2, Genetic Predisposition to Disease, Humans, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Germ-Line Mutation
Abstract: It is 30 years since the first diagnostic cancer predisposition gene (CPG) test in the Manchester Centre for Genomic Medicine (MCGM), providing opportunities for cancer prevention, early detection and targeted treatments in index cases and at-risk family members. Here, we present time trends (1990-2020) of identification of index cases with a germline CPG variant and numbers of subsequent cascade tests, for 15 high-risk breast and gastro-intestinal tract cancer-associated CPGs: BRCA1, BRCA2, PALB2, PTEN, TP53, APC, BMPR1a, CDH1, MLH1, MSH2, MSH6, PMS2, SMAD4, STK11 and MUTYH. We recorded 2082 positive index case diagnostic screening tests, generating 3216 positive and 3140 negative family cascade (non-index) tests. This is equivalent to an average of 3.05 subsequent cascade tests per positive diagnostic index test, with 1.54 positive and 1.51 negative non-index tests per family. The CPGs with the highest numbers of non-index positive cases identified on cascade testing were BRCA1/2 (n = 1999) and the mismatch repair CPGs associated with Lynch Syndrome (n = 731). These data are important for service provision and health economic assessment of CPG diagnostic testing, in terms of cancer prevention and early detection strategies, and identifying those likely to benefit from targeted treatment strategies., (© 2021. The Author(s).)
Published: 2022
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16. Implementation of Multigene Germline and Parallel Somatic Genetic Testing in Epithelial Ovarian Cancer: SIGNPOST Study.

Author: Chandrasekaran D, Sobocan M, Blyuss O, Miller RE, Evans O, Crusz SM, Mills-Baldock T, Sun L, Hammond RFL, Gaba F, Jenkins LA, Ahmed M, Kumar A, Jeyarajah A, Lawrence AC, Brockbank E, Phadnis S, Quigley M, El Khouly F, Wuntakal R, Faruqi A, Trevisan G, Casey L, Burghel GJ, Schlecht H, Bulman M, Smith P, Bowers NL, Legood R, Lockley M, Wallace A, Singh N, Evans DG, and Manchanda R
Abstract: We present findings of a cancer multidisciplinary-team (MDT) coordinated mainstreaming pathway of unselected 5-panel germline BRCA1/BRCA2/RAD51C/RAD51D/BRIP1 and parallel somatic BRCA1/BRCA2 testing in all women with epithelial-OC and highlight the discordance between germline and somatic testing strategies across two cancer centres. Patients were counselled and consented by a cancer MDT member. The uptake of parallel multi-gene germline and somatic testing was 97.7%. Counselling by clinical-nurse-specialist more frequently needed >1 consultation (53.6% (30/56)) compared to a medical (15.0% (21/137)) or surgical oncologist (15.3% (17/110)) ( p < 0.001). The median age was 54 (IQR = 51-62) years in germline pathogenic-variant (PV) versus 61 (IQR = 51-71) in BRCA wild-type ( p = 0.001). There was no significant difference in distribution of PVs by ethnicity, stage, surgery timing or resection status. A total of 15.5% germline and 7.8% somatic BRCA1/BRCA2 PVs were identified. A total of 2.3% patients had RAD51C/RAD51D/BRIP1 PVs. A total of 11% germline PVs were large-genomic-rearrangements and missed by somatic testing. A total of 20% germline PVs are missed by somatic first BRCA -testing approach and 55.6% germline PVs missed by family history ascertainment. The somatic testing failure rate is higher (23%) for patients undergoing diagnostic biopsies. Our findings favour a prospective parallel somatic and germline panel testing approach as a clinically efficient strategy to maximise variant identification. UK Genomics test-directory criteria should be expanded to include a panel of OC genes.
Published: 2021
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17. Mainstreaming germline BRCA1/2 testing in non-mucinous epithelial ovarian cancer in the North West of England.

Author: Flaum N, Morgan RD, Burghel GJ, Bulman M, Clamp AR, Hasan J, Mitchell CL, Badea D, Moon S, Hogg M, Hadjiyiannakis D, Clancy T, Schlecht H, Woodward ER, Crosbie EJ, Edmondson RJ, Wallace AJ, Jayson GC, Lalloo FI, Harkness EF, and Evans DGR
Subjects: Adult, Aged, Carcinoma, Ovarian Epithelial diagnosis, England, Female, Genetic Testing standards, Genetic Testing statistics & numerical data, Germ-Line Mutation, Humans, Middle Aged, Ovarian Neoplasms diagnosis, BRCA1 Protein genetics, BRCA2 Protein genetics, Carcinoma, Ovarian Epithelial genetics, Genetic Testing methods, Ovarian Neoplasms genetics
Abstract: Poly(ADP-ribose) polymerase (PARP) inhibitors improve survival in BRCA-mutant high-grade serous ovarian carcinoma. As a result, germline and somatic BRCA1/2 testing has become standard practice in women diagnosed with ovarian cancer. We outline changes in testing and detection rates of germline BRCA1/2 pathogenic variants (PVs) in cases of non-mucinous epithelial ovarian cancer diagnosed during three eras, spanning 12 years, within the North West of England, and compare the uptake of cascade testing in families identified by oncology-led mainstreaming versus regional genetics clinics. Eras included: Period 1 (20% risk threshold for testing): between January 2007 and May 2013; Period 2 (10% risk threshold for testing): between June 2013 and October 2017 and; Period 3 (mainstream testing): between November 2017 and November 2019. A total of 1081 women underwent germline BRCA1/2 testing between January 2007 and November 2019 and 222 (20.5%) were found to have a PV. The monthly testing rate increased by 3.3-fold and 2.5-fold between Periods 1-2 and Periods 2-3, respectively. A similar incidence of germline BRCA1/2 PVs were detected in Period 2 (17.2%) and Period 3 (18.5%). Uptake of cascade testing from first-degree relatives was significantly lower in those women undergoing mainstream testing compared with those tested in regional genetics clinics (31.6% versus 47.3%, P = 0.038). Mainstream testing allows timely detection of germline BRCA1/2 status to select patients for PARP inhibitors, but shortfalls in the uptake of cascade testing in first-degree relatives requires optimisation to broaden benefits within families.
Published: 2020
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18. Prevalence of germline pathogenic BRCA1/2 variants in sequential epithelial ovarian cancer cases.

Author: Morgan RD, Burghel GJ, Flaum N, Bulman M, Clamp AR, Hasan J, Mitchell CL, Schlecht H, Woodward ER, Lallo FI, Crosbie EJ, Edmondson RJ, Wallace AJ, Jayson GC, and Evans DGR
Subjects: Adult, Aged, Biomarkers, Tumor, Carcinoma, Ovarian Epithelial diagnosis, Carcinoma, Ovarian Epithelial mortality, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genetic Testing, Humans, Middle Aged, Neoplasm Grading, Ovarian Neoplasms diagnosis, Ovarian Neoplasms mortality, Prevalence, Prognosis, Risk Factors, Young Adult, BRCA1 Protein genetics, BRCA2 Protein genetics, Carcinoma, Ovarian Epithelial epidemiology, Carcinoma, Ovarian Epithelial genetics, Germ-Line Mutation, Ovarian Neoplasms epidemiology, Ovarian Neoplasms genetics
Abstract: Introduction: Poly(ADP-ribose) polymerase inhibitors significantly improve progression-free survival in platinum-sensitive high-grade serous and endometrioid ovarian carcinoma, with greatest benefits observed in women with a pathogenic BRCA1 / 2 variant. Consequently, the demand for germline BRCA1/2 testing in ovarian cancer has increased substantially, leading to the screening of unselected populations of patients. We aimed to determine the prevalence of pathogenic germline BRCA1/2 variants in women diagnosed with epithelial ovarian cancer, categorised according to the established risk factors for hereditary breast and ovarian cancer syndrome and the Manchester BRCA Score, to inform risk stratification., Methods: A cohort of sequential epithelial ovarian cancer cases recruited between June 2013 and September 2018 underwent germline BRCA1/2 testing by next-generation sequencing and multiplex ligation-dependent probe amplification., Results: Five hundred and fifty-seven patients were screened. Of these, 18% had inherited a pathogenic BRCA1 / 2 variant. The prevalence of pathogenic BRCA1/2 variants was >10% in women diagnosed with ovarian cancer earlier than 60 years of age (21%) and those diagnosed later than 60 years of age with a family history of breast and/or ovarian cancer (17%) or a medical history of breast cancer (34%). The prevalence of pathogenic BRCA1/2 variants was also >10% in women with a Manchester BRCA Score of ≥15 points (14%)., Discussion: Our study suggests that age at diagnosis, family history of breast and/or ovarian cancer, medical history of breast cancer or a Manchester BRCA Score of ≥15 points are associated with a >10% prevalence of germline pathogenic BRCA1 / 2 variants in epithelial ovarian cancer., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.)
Published: 2019
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19. Non-invasive Intracranial Pressure Assessment in Brain Injured Patients Using Ultrasound-Based Methods.

Author: Robba C, Cardim D, Tajsic T, Pietersen J, Bulman M, Rasulo F, Bertuetti R, Donnelly J, Xiuyun L, Czosnyka Z, Cabeleira M, Smielewski P, Matta B, Bertuccio A, and Czosnyka M
Subjects: Aged, Brain Injuries, Traumatic complications, Brain Injuries, Traumatic physiopathology, Female, Humans, Intracranial Hypertension etiology, Intracranial Hypertension physiopathology, Intracranial Pressure, Linear Models, Male, Middle Aged, Sensitivity and Specificity, Subarachnoid Hemorrhage complications, Subarachnoid Hemorrhage physiopathology, Ultrasonography, Ultrasonography, Doppler, Transcranial, Brain Injuries, Traumatic diagnostic imaging, Cerebral Arteries diagnostic imaging, Cerebral Veins diagnostic imaging, Intracranial Hypertension diagnostic imaging, Monitoring, Physiologic methods, Optic Nerve diagnostic imaging, Subarachnoid Hemorrhage diagnostic imaging
Abstract: Background: Non-invasive measurement of intracranial pressure (ICP) can be invaluable in the management of critically ill patients. Invasive measurement of ICP remains the "gold standard" and should be performed when clinical indications are met, but it is invasive and brings some risks. In this project, we aim to validate the non-invasive ICP (nICP) assessment models based on arterious and venous transcranial Doppler ultrasonography (TCD) and optic nerve sheath diameter (ONSD)., Methods: We included brain injured patients requiring invasive ICP monitoring (intraparenchymal or intraventricular). We assessed the concordance between ICP measured non-invasively with arterious [flow velocity diastolic formula (ICP FVd ) and pulsatility index (PI)], venous TCD (vPI) and ICP derived from ONSD (nICP ONSD ) compared to invasive ICP measurement., Results: Linear regression showed a positive relationship between nICP and ICP for all the methods, except PIv. ICP ONSD showed the strongest correlation with invasive ICP (r = 0.61) compared to the other methods (ICP FVd , r = 0.26, p value = 0.0015; PI, r = 0.19, p value = 0.02, vPI, r = 0.056, p value = 0.510). The ability to predict intracranial hypertension was highest for ICP ONSD (AUC = 0.91; 95% CI, 0.85-0.97 at ICP > 20 mmHg), with a sensitivity and specificity of 85%, followed by ICP FVd (AUC = 0.67; 95% CI, 0.54-0.79)., Conclusions: Our results demonstrate that among the non-invasive methods studied, ONSD showed the best accuracy in the detection of ICP.
Published: 2018
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20. Ultrasound non-invasive measurement of intracranial pressure in neurointensive care: A prospective observational study.

Author: Robba C, Cardim D, Tajsic T, Pietersen J, Bulman M, Donnelly J, Lavinio A, Gupta A, Menon DK, Hutchinson PJA, and Czosnyka M
Subjects: Adult, Aged, Area Under Curve, Craniocerebral Trauma complications, Female, Humans, Intensive Care Units, Intracranial Hypertension diagnosis, Intracranial Hypertension etiology, Male, Middle Aged, Monitoring, Physiologic instrumentation, Organ Size, Prospective Studies, Sensitivity and Specificity, Craniocerebral Trauma diagnostic imaging, Intracranial Hypertension diagnostic imaging, Intracranial Pressure, Monitoring, Physiologic methods, Optic Nerve diagnostic imaging, Ultrasonography
Abstract: Background: The invasive nature of the current methods for monitoring of intracranial pressure (ICP) has prevented their use in many clinical situations. Several attempts have been made to develop methods to monitor ICP non-invasively. The aim of this study is to assess the relationship between ultrasound-based non-invasive ICP (nICP) and invasive ICP measurement in neurocritical care patients., Methods and Findings: This was a prospective, single-cohort observational study of patients admitted to a tertiary neurocritical care unit. Patients with brain injury requiring invasive ICP monitoring were considered for inclusion. nICP was assessed using optic nerve sheath diameter (ONSD), venous transcranial Doppler (vTCD) of straight sinus systolic flow velocity (FVsv), and methods derived from arterial transcranial Doppler (aTCD) on the middle cerebral artery (MCA): MCA pulsatility index (PIa) and an estimator based on diastolic flow velocity (FVd). A total of 445 ultrasound examinations from 64 patients performed from 1 January to 1 November 2016 were included. The median age of the patients was 53 years (range 37-64). Median Glasgow Coma Scale at admission was 7 (range 3-14), and median Glasgow Outcome Scale was 3 (range 1-5). The mortality rate was 20%. ONSD and FVsv demonstrated the strongest correlation with ICP (R = 0.76 for ONSD versus ICP; R = 0.72 for FVsv versus ICP), whereas PIa and the estimator based on FVd did not correlate with ICP significantly. Combining the 2 strongest nICP predictors (ONSD and FVsv) resulted in an even stronger correlation with ICP (R = 0.80). The ability to detect intracranial hypertension (ICP ≥ 20 mm Hg) was highest for ONSD (area under the curve [AUC] 0.91, 95% CI 0.88-0.95). The combination of ONSD and FVsv methods showed a statistically significant improvement of AUC values compared with the ONSD method alone (0.93, 95% CI 0.90-0.97, p = 0.01). Major limitations are the heterogeneity and small number of patients included in this study, the need for specialised training to perform and interpret the ultrasound tests, and the variability in performance among different ultrasound operators., Conclusions: Of the studied ultrasound nICP methods, ONSD is the best estimator of ICP. The novel combination of ONSD ultrasonography and vTCD of the straight sinus is a promising and easily available technique for identifying critically ill patients with intracranial hypertension.
Published: 2017
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21. SMARCE1 mutation screening in classification of clear cell meningiomas.

Author: Smith MJ, Ahn S, Lee JI, Bulman M, Plessis DD, and Suh YL
Subjects: Adolescent, Adult, Child, DNA Mutational Analysis, Female, Humans, Immunohistochemistry, Male, Meningeal Neoplasms pathology, Meningioma pathology, Middle Aged, Multiplex Polymerase Chain Reaction, Young Adult, Chromosomal Proteins, Non-Histone genetics, DNA-Binding Proteins genetics, Meningeal Neoplasms classification, Meningeal Neoplasms genetics, Meningioma classification, Meningioma genetics
Abstract: Aims: Clear cell meningioma (CCM) is a rare subtype of meningioma and shows not only unusual histology, but also unique clinical features. Recently, SMARCE1 mutations have been shown to cause spinal and cranial CCMs. We present 12 cases which were diagnosed with CCM in a single institution between 1997 and 2014, and investigate their SMARCE1 mutation status., Methods and Results: To investigate the SMARCE1 mutation status of these tumours, we used a combination of Sanger sequencing and multiplex ligation-dependent probe amplification analysis and also performed SMARCE1 immunohistochemical staining. We found both SMARCE1 mutational hits, including novel SMARCE1 mutations, in six of eight tested patients. Immunohistochemical analysis showed loss of SMARCE1 protein staining in all but two cases. Two individuals who were diagnosed originally with CCM were negative for SMARCE1 mutations, but tested positive for NF2 mutations. As a result, these two tumours were re-analysed and eventually reclassified, as a microcystic and a mixed pattern of meningothelial meningioma with focal clear cell areas, respectively., Conclusions: These results expand the spectrum of pathogenic variants in SMARCE1 and show that mutation screening can help to facilitate meningioma classification. This may have implications for prognosis and future clinical management of patients, as CCMs are classed as grade II tumours, while microcystic and meningothelial meningiomas are classed as grade I., (© 2016 John Wiley & Sons Ltd.)
Published: 2017
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22. Revisiting neurofibromatosis type 2 diagnostic criteria to exclude LZTR1-related schwannomatosis.

Author: Smith MJ, Bowers NL, Bulman M, Gokhale C, Wallace AJ, King AT, Lloyd SK, Rutherford SA, Hammerbeck-Ward CL, Freeman SR, and Evans DG
Subjects: Adult, Cohort Studies, Databases, Factual statistics & numerical data, Female, Functional Laterality genetics, Humans, Loss of Heterozygosity genetics, Male, Middle Aged, Neurofibromatosis 2 complications, Neurofibromatosis 2 genetics, Neurofibromin 2 genetics, Germ-Line Mutation genetics, Neurilemmoma genetics, Neurofibromatoses genetics, Neurofibromatosis 2 diagnosis, Neuroma, Acoustic complications, Neuroma, Acoustic etiology, Neuroma, Acoustic genetics, Skin Neoplasms genetics, Transcription Factors genetics
Abstract: Objective: To determine the specificity of the current clinical diagnostic criteria for neurofibromatosis type 2 (NF2) relative to the requirement for unilateral vestibular schwannoma (VS) and at least 2 other NF2-related tumors., Methods: We interrogated our Manchester NF2 database, which contained 205 individuals meeting NF2 criteria who initially presented with a unilateral VS. Of these, 83 (40.7%) went on to develop a contralateral VS. We concentrated our genetic analysis on a group of 70 who initially fulfilled NF2 criteria with a unilateral vestibular schwannoma and at least 2 additional nonintradermal schwannomas., Results: Overall, 5/70 (7%) individuals with unilateral VS and at least 2 other schwannomas had a pathogenic or likely pathogenic LZTR1 mutation. Twenty of the 70 subsequently developed bilateral disease. Of the remaining 50, 5 (10%) had a germline LZTR1 mutation, equivalent to the number (n = 5) with a germline NF2 mutation., Conclusions: The most common etiology for unilateral VS and 2 additional NF2-associated tumors in this cohort was mosaic NF2. Germline LZTR1 and germline NF2 mutations were equally common in our cohort. This indicates that LZTR1 must be considered when making a diagnosis of NF2 in the presence of unilateral VS in individuals without a germline NF2 mutation., (© 2016 American Academy of Neurology.)
Published: 2017
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23. A Case of Possible Iatrogenic Ketamine-Induced Mania in a Patient Being Treated for Postoperative Pain.

Author: Nichols SD, Bulman M, Tisher A, and Campbell JJ 3rd
Subjects: Adult, Analgesics therapeutic use, Humans, Iatrogenic Disease, Ketamine therapeutic use, Male, Analgesics adverse effects, Bipolar Disorder chemically induced, Ketamine adverse effects, Pain, Postoperative drug therapy
Published: 2016
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24. The Contribution of Whole Gene Deletions and Large Rearrangements to the Mutation Spectrum in Inherited Tumor Predisposing Syndromes.

Author: Smith MJ, Urquhart JE, Harkness EF, Miles EK, Bowers NL, Byers HJ, Bulman M, Gokhale C, Wallace AJ, Newman WG, and Evans DG
Subjects: Adult, BRCA1 Protein genetics, BRCA2 Protein genetics, DNA-Binding Proteins genetics, Female, Genotype, Germ-Line Mutation genetics, Humans, Middle Aged, MutS Homolog 2 Protein genetics, Mutation genetics, Tumor Suppressor Protein p53 genetics, Chromosomes, Human, Pair 22 genetics, Gene Deletion
Abstract: Heterozygous whole gene deletions (WGDs), and intragenic microdeletions, account for a significant proportion of mutations underlying cancer predisposition syndromes. We analyzed the frequency and genotype-phenotype correlations of microdeletions in 12 genes (BRCA1, BRCA2, TP53, MSH2, MLH1, MSH6, PMS2, NF1, NF2, APC, PTCH1, and VHL) representing seven tumor predisposition syndromes in 5,897 individuals (2,611 families) from our center. Overall, microdeletions accounted for 14% of identified mutations. As expected, smaller deletions or duplications were more common (12%) than WGDs (2.2%). Where a WGD was identified in the germline in NF2, the mechanism of somatic second hit was not deletion, as previously described for NF1. For neurofibromatosis type 1 and 2, we compared the mechanism of germline deletion. Unlike NF1, where three specific deletion sizes account for most germline WGDs, NF2 deletion breakpoints were different across seven samples tested. One of these deletions was 3.93 Mb and conferred a severe phenotype, thus refining the region for a potential NF2 modifier gene to a 2.04-Mb region on chromosome 22. The milder phenotype of NF2 WGDs may be due to the apparent absence of chromosome 22 loss as the second hit. These observations of WGD phenotypes will be helpful for interpreting incidental findings from microarray analysis and next-generation sequencing., (© 2015 WILEY PERIODICALS, INC.)
Published: 2016
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25. Cultural Sensitivity and Challenges in Management of the Transgender Patient With ESRD in Transplantation.

Author: Hoch DA, Bulman M, and McMahon DW
Subjects: Androgens therapeutic use, Estrogens therapeutic use, Female, Humans, Living Donors, Male, Postoperative Complications epidemiology, Self Disclosure, Terminology as Topic, Thromboembolism epidemiology, Cultural Competency, Kidney Failure, Chronic surgery, Kidney Transplantation methods, Transgender Persons
Abstract: Transgender patients with end-stage renal disease (ESRD) present with specific challenges during the transplant evaluation, perioperative management, and postoperative phase of care. Demographic information, health-care records, chosen name, and gender identity along with documentation of specific health-care needs can become a challenge when gender assigned at birth is incongruent with the patients gender identity. Medical care involves addressing the end-organ disease as well as addressing those aspects of care specific to the transgender patient. This review article provides information on defining transgender, the impact of ESRD, and transgender in the transplant process and considerations in the throughout phases of care. Current recommendations for management of this unique population are provided., (© 2016, NATCO.)
Published: 2016
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26. Risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a 30-year semi-prospective analysis.

Author: Basu NN, Ingham S, Hodson J, Lalloo F, Bulman M, Howell A, and Evans DG
Subjects: Adult, Breast Neoplasms genetics, Breast Neoplasms pathology, Cross-Sectional Studies, Female, Follow-Up Studies, Heterozygote, Humans, Middle Aged, Neoplasm Staging, Prognosis, Prospective Studies, Retrospective Studies, Risk Factors, Time Factors, United Kingdom epidemiology, Young Adult, BRCA1 Protein genetics, BRCA2 Protein genetics, Breast Neoplasms epidemiology, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide genetics
Abstract: BRCA1 and BRCA2 mutation carriers have an increased risk of contralateral breast cancer after primary breast cancer. Risk reduction strategies are discussed after assessment of risk factors for developing contralateral breast cancer. We assessed potential risk factors that could be of use in clinical practice, including the novel use of single nucleotide polymorphisms (SNP) testing. 506 BRCA1 and 505 BRCA2 mutation carriers with a diagnosis of breast cancer were observed for up to 30 years. The risk of a contralateral breast cancer is approximately 2-3% per year, remaining constant for at least 20 years. This was similar in both BRCA1 and BRCA2 carriers. Initial breast cancer before age 40-years was a significant risk factor, which was more pronounced in BRCA1 patients. The effect of risk-reducing oophorectomy on contralateral breast cancer risk may be overestimated because of bias. No significant association was found between overall breast cancer risk SNP score and contralateral breast cancer development. Young mutation carriers, particularly those with BRCA1 mutations, who develop breast cancer have a significantly higher risk of developing contralateral breast cancer, remaining constant for over 20 years. Contralateral risk-reducing mastectomy should be considered in this group, in particular as there is a survival benefit. Caution is advised when counselling women considering risk-reducing oophorectomy as, after accounting for statistical bias, the associated risk reduction was found to be non-significant, and potentially smaller than has been previously reported. SNP testing did not add any further discriminatory information when assessing contralateral breast cancer risk.
Published: 2015
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27. (1H-Pyrazole-κN)bis-(tri-tert-but-oxy-silane-thiol-ato-κ(2) O,S)cadmium.

Author: Baranowska K, Bulman M, and Dołęga A
Abstract: The Cd(II) atom in the title complex, [Cd(C12H27O3SSi)2(C3H4N2)], is penta-coordinated by two O and two S atoms from the O,S-chelating silane-thiol-ate residue and one pyrazole N atom in a distorted geometry that is slightly closer to trigonal-bipyramidal than to square-based pyramidal. The pyrazole ligand is stabilized within the complex by an intra-molecular N-H⋯O hydrogen bond. One of the tert-butyl groups is disordered over two orientations with occupancy ratio of 0.534 (6):0.466 (6).
Published: 2012
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28. The study of cystic fibrosis transmembrane conductance regulator gene mutations in a group of patients from Romania.

Author: Frenţescu L, Brownsell E, Hinks J, Malone G, Shaw H, Budişan L, Bulman M, Schwarz M, Pop L, Filip M, Tomescu E, Moşescu S, Popa I, and Benga G
Subjects: Cystic Fibrosis epidemiology, Female, Gene Frequency, Humans, Male, Polymerase Chain Reaction, Romania epidemiology, Cystic Fibrosis genetics, Cystic Fibrosis Transmembrane Conductance Regulator genetics, DNA Mutational Analysis
Abstract: Background: Cystic fibrosis (CF) is produced by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator Gene (CFTR) gene., Methods: One hundred twenty eight patients with CF were analysed for mutations in the CFTR gene in order to establish the frequency of CF mutations in the Romanian population. The chief methods of analysis were polymerase chain reaction (PCR) of DNA extracted from blood and electrophoresis of PCR products., Results: The frequency of F508del in CF chromosomes from Romania is approximately 56.3%. Other frequent mutations noted are: G542X (3.9%), W1282X (2.3%), and CFTRdele2,3(21 kb)(1.6%); the remaining mutations have frequencies below 1%., Conclusions: We consider that the frequency of F508del in CF patients from Romania is higher than in previous reports, reaching 56.3%, probably owing to more rigorous selection of patients for genetic testing, allowing improved calculation of mutation frequencies.
Published: 2008
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29. Probability of BRCA1/2 mutation varies with ovarian histology: results from screening 442 ovarian cancer families.

Author: Evans DG, Young K, Bulman M, Shenton A, Wallace A, and Lalloo F
Subjects: Breast Neoplasms genetics, Female, Humans, Middle Aged, Ovarian Neoplasms pathology, Probability, Retrospective Studies, Sensitivity and Specificity, BRCA1 Protein genetics, BRCA2 Protein genetics, Mutation, Ovarian Neoplasms genetics, Ovary pathology
Abstract: While there are many reports in the literature of mutation testing of BRCA1 and BRCA2 in breast/ovarian cancer families, the question of which type of ovarian cancers are relevant still pertains. We have undertaken whole gene screening including multiple ligation-dependent probe amplification in an affected individual within 442 unrelated non-Jewish families containing at least one reported ovarian cancer diagnosed less than 50 years or at any age with family history of breast or ovarian cancer for mutations in BRCA1 and BRCA2. A total of 166 mutations were identified 110 (25%) in BRCA1 and 56 (13%) in BRCA2. In families without confirmation of ovarian diagnosis, the detection rate drops significantly. In families fulfilling Breast Cancer Linkage Consortium (BCLC) criteria with confirmed ovarian cancer cases, the mutation detection frequency was 80%. If only BCLC families with unconfirmed ovarian cancers were included, the detection rate dropped to 36% when a relevant ovarian cancer diagnosis was not confirmed. In BCLC families containing only one ovarian cancer, BRCA2 accounted for 45% of identified mutations. No mutations were identified in affected individuals with borderline or mucinous tumours. Detection rates dropped below the 10/20% international thresholds in a number of families with unconfirmed ovarian cancers. Borderline/mucinous pathology substantially reduces the likelihood of identifying a BRCA1/2 mutation. Strenuous efforts should be made to confirm ovarian pathology if the lack of confirmation or refuting the diagnosis would decrease a family's likelihood of mutation detection below screening thresholds. In the UK, a higher proportion of families harbour BRCA2 pathogenic mutations than predicted from previous studies.
Published: 2008
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30. BRCA1/2 mutation analysis in male breast cancer families from North West England.

Author: Evans DG, Bulman M, Young K, Howard E, Bayliss S, Wallace A, and Lalloo F
Subjects: Breast Neoplasms, Male epidemiology, DNA Mutational Analysis, England epidemiology, Genetic Diseases, Inborn, Genetic Testing, Humans, Male, Middle Aged, Risk Factors, BRCA1 Protein genetics, BRCA2 Protein genetics, Breast Neoplasms, Male genetics, Genes, BRCA1, Genes, BRCA2, Mutation
Abstract: 64 families with a history of male breast cancer aged 60 or less or with a family history of male and female breast cancer were screened for the presence of BRCA1 and BRCA2 mutations. Seventeen pathogenic BRCA2 and four BRCA1 mutations were identified (34%) in samples from an affected family member. All but one of the mutations segregated with disease where samples were available and pedigree structure permitted. Despite high sensitivity of mutation testing only 64% of families fulfilling BCLC criteria had an identifiable pathogenic mutation. It is possible that at least some of these families may have mutations in other genes, although we found no involvement of CHEK2 1100delC.
Published: 2008
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31. Phenocopies in BRCA1 and BRCA2 families: evidence for modifier genes and implications for screening.

Author: Smith A, Moran A, Boyd MC, Bulman M, Shenton A, Smith L, Iddenden R, Woodward ER, Lalloo F, Maher ER, and Evans DG
Subjects: Adult, Aged, Aged, 80 and over, Breast Neoplasms genetics, Family, Female, Genetic Predisposition to Disease, Humans, Middle Aged, Mutation, Ovarian Neoplasms genetics, Phenotype, Breast Neoplasms diagnosis, Genes, BRCA1, Genes, BRCA2, Genetic Testing, Ovarian Neoplasms diagnosis
Abstract: Background: The identification of BRCA1 and BRCA2 mutations in familial breast cancer kindreds allows genetic testing of at-risk relatives. Those who test negative are usually reassured and additional breast cancer surveillance is discontinued. However, we postulated that in high-risk families, such as those seen in clinical genetics centres, the risk of breast cancer might be influenced not only by the BRCA1/BRCA2 mutation but also by modifier genes. One manifestation of this would be the presence of phenocopies in BRCA1/BRCA2 kindreds., Methods: 277 families with pathogenic BRCA1/BRCA2 mutations were reviewed and 28 breast cancer phenocopies identified. The relative risk of breast cancer in those testing negative was assessed using incidence rates from our cancer registry based on local population., Results: Phenocopies constituted up to 24% of tests on women with breast cancer after the identification of the mutation in the proband. The standardised incidence ratio for women who tested negative for the BRCA1/BRCA2 family mutation was 5.3 for all relatives, 5.0 for all first-degree relatives (FDRs) and 3.2 (95% confidence interval 2.0 to 4.9) for FDRs in whose family all other cases of breast and ovarian cancer could be explained by the identified mutation. 13 of 107 (12.1%) FDRs with breast cancer and no unexplained family history tested negative., Conclusion: In high-risk families, women who test negative for the familial BRCA1/BRCA2 mutation have an increased risk of breast cancer consistent with genetic modifiers. In light of this, such women should still be considered for continued surveillance.
Published: 2007
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32. A new scoring system for the chances of identifying a BRCA1/2 mutation outperforms existing models including BRCAPRO.

Author: Evans DG, Eccles DM, Rahman N, Young K, Bulman M, Amir E, Shenton A, Howell A, and Lalloo F
Subjects: Algorithms, Breast Neoplasms diagnosis, Breast Neoplasms genetics, Female, Genetic Testing methods, Genetic Testing statistics & numerical data, Humans, Male, Ovarian Neoplasms diagnosis, Ovarian Neoplasms genetics, Reproducibility of Results, Sensitivity and Specificity, BRCA1 Protein genetics, BRCA2 Protein genetics, Models, Statistical, Mutation
Abstract: Purpose: To develop a simple scoring system for the likelihood of identifying a BRCA1 or BRCA2 mutation., Methods: DNA samples from affected subjects from 422 non-Jewish families with a history of breast and/or ovarian cancer were screened for BRCA1 mutations and a subset of 318 was screened for BRCA2 by whole gene screening techniques. Using a combination of results from screening and the family history of mutation negative and positive kindreds, a simple scoring system (Manchester scoring system) was devised to predict pathogenic mutations and particularly to discriminate at the 10% likelihood level. A second separate dataset of 192 samples was subsequently used to test the model's predictive value. This was further validated on a third set of 258 samples and compared against existing models., Results: The scoring system includes a cut-off at 10 points for each gene. This equates to >10% probability of a pathogenic mutation in BRCA1 and BRCA2 individually. The Manchester scoring system had the best trade-off between sensitivity and specificity at 10% prediction for the presence of mutations as shown by its highest C-statistic and was far superior to BRCAPRO., Conclusion: The scoring system is useful in identifying mutations particularly in BRCA2. The algorithm may need modifying to include pathological data when calculating whether to screen for BRCA1 mutations. It is considerably less time-consuming for clinicians than using computer models and if implemented routinely in clinical practice will aid in selecting families most suitable for DNA sampling for diagnostic testing.
Published: 2004
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33. Haplotype and cancer risk analysis of two common mutations, BRCA1 4184del4 and BRCA2 2157delG, in high risk northwest England breast/ovarian families.

Author: Evans DG, Neuhausen SL, Bulman M, Young K, Gokhale D, and Lalloo F
Subjects: Adult, Aged, Aged, 80 and over, BRCA1 Protein genetics, BRCA2 Protein genetics, Breast Neoplasms epidemiology, DNA, Neoplasm genetics, England epidemiology, Female, Founder Effect, Humans, Incidence, Male, Middle Aged, Pedigree, Risk Assessment, Breast Neoplasms genetics, Breast Neoplasms, Male genetics, Genes, BRCA1, Genes, BRCA2, Haplotypes genetics, Mutation genetics, Ovarian Neoplasms genetics, Sequence Deletion genetics
Published: 2004
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34. Sensitivity of BRCA1/2 mutation testing in 466 breast/ovarian cancer families.

Author: Evans DG, Bulman M, Young K, Gokhale D, and Lalloo F
Subjects: Bayes Theorem, DNA Mutational Analysis methods, Family Health, Female, Humans, Mutation, Polymorphism, Single-Stranded Conformational, Sensitivity and Specificity, BRCA1 Protein genetics, BRCA2 Protein genetics, Breast Neoplasms genetics, Genetic Testing methods, Ovarian Neoplasms genetics
Published: 2003
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35. Evidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutations.

Author: Thomas H, Badenberg B, Bulman M, Lemm I, Lausen J, Kind L, Roosen S, Ellard S, Hattersley AT, and Ryffel GU
Subjects: Blotting, Northern, Blotting, Western, Cells, Cultured, DNA genetics, DNA Primers, Electrophoresis, Agar Gel, Fluorescent Antibody Technique, Genes, Reporter genetics, Genetic Vectors, Haploidy, Hepatocyte Nuclear Factor 1, Hepatocyte Nuclear Factor 1-alpha, Hepatocyte Nuclear Factor 1-beta, Humans, Protein Biosynthesis, RNA, Messenger biosynthesis, RNA, Messenger genetics, RNA, Messenger isolation & purification, Subcellular Fractions metabolism, Transcriptional Activation genetics, DNA-Binding Proteins, Diabetes Mellitus, Type 2 genetics, Mutation genetics, Nuclear Proteins, Transcription Factors genetics
Abstract: Hepatocyte nuclear factor (HNF)1alpha is a homeo-domain-containing transcription factor participating in the regulation of gene expression in liver, kidney, gut and pancreas of vertebrates. In humans mutations in the HNF1 gene are responsible for one form of maturity onset diabetes of the young (MODY3). To define the molecular mechanism underlying MODY3 we investigated the functional properties of seven MODY3-associated mutations representing the spectrum of different kinds of mutations affecting all functional domains of the protein. The mutations introduced into an expression vector encoding human HNF1alpha include in-frame deletion (AN127), nonsense (Q7X, R171X), frameshift (P291fsinsC) and missense (R229Q, P447L, T6201) mutations. Gel retardation and reporter gene assays showed that the functional properties of these mutants differ dramatically, but none of these mutants act in a dominant negative manner. Moreover, the mRNA stability of the mutants AN127, R171X, P291fsinsC and T547E548fsdelTG is impaired compared to the wild-type sequence in transfected cells. This decreased RNA stability is independent of the presence of an intron in the expression vector and thus differs from mechanisms known to be involved in nonsense-mediated decay (NMD). Our results suggest that haploinsufficiency of HNF1alpha is responsible for the pathogenesis of MODY3.
Published: 2002
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36. A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young.

Author: Thomas H, Jaschkowitz K, Bulman M, Frayling TM, Mitchell SM, Roosen S, Lingott-Frieg A, Tack CJ, Ellard S, Ryffel GU, and Hattersley AT
Subjects: Adult, Animals, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, DNA Primers chemistry, DNA-Binding Proteins metabolism, Electrophoretic Mobility Shift Assay, Female, Hepatocyte Nuclear Factor 4, Humans, In Vitro Techniques, Islets of Langerhans metabolism, Luciferases metabolism, Male, Mice, Middle Aged, Molecular Sequence Data, Mutation, Pedigree, Reverse Transcriptase Polymerase Chain Reaction, Trans-Activators metabolism, Tumor Cells, Cultured physiology, DNA-Binding Proteins genetics, Diabetes Mellitus, Type 2 genetics, Homeodomain Proteins, Phosphoproteins genetics, Promoter Regions, Genetic, Transcription Factors genetics
Abstract: Maturity-onset diabetes of the young (MODY) is a monogenic, autosomal dominant subtype of early-onset diabetes mellitus due to defective insulin secretion by the pancreatic beta-cell in humans. Five different genes have been identified including those encoding the tissue-specific transcription factors expressed in pancreatic beta-cells, i.e. HNF-4alpha (MODY1), HNF-1alpha (MODY3), IPF-1 (also known as PDX-1, MODY4) and HNF-1beta (MODY5). Analyzing the transcription of the HNF-4alpha gene, we now identify an alternative promoter, P2, which is 46 kb 5' to the previously identified P1 promoter of the human gene. Based on RT-PCR this distant upstream P2 promoter represents the major transcription site in pancreatic beta-cells, but is also used in hepatic cells. Transfection assays with various deletions and mutants of the P2 promoter reveal functional binding sites for HNF-1alpha, HNF-1beta and IPF-1, the other transcription factors known to encode MODY genes. We demonstrate the significance of this alternative promoter in a large MODY family where a mutated IPF-1 binding site in the P2 promoter of the HNF-4alpha gene co-segregates with diabetes (LOD score 3.25). These data suggest a regulatory network of the four MODY transcription factors interconnected at the distant upstream P2 promoter of the HNF-4alpha gene.
Published: 2001
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37. High detection rate for BRCA2 mutations in male breast cancer families from North West England.

Author: Evans DG, Bulman M, Young K, Gokhale D, and Lalloo F
Subjects: Adult, Aged, Aged, 80 and over, DNA Mutational Analysis, DNA, Neoplasm analysis, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Ovarian Neoplasms genetics, Polymerase Chain Reaction, Polymorphism, Single-Stranded Conformational, Prostatic Neoplasms genetics, BRCA2 Protein genetics, Breast Neoplasms, Male genetics, Mutation
Abstract: 33 families with a history of male breast cancer aged 60 or less or with a family history of male and female breast cancer were screened for the presence of BRCA2 mutations. 12 pathogenic BRCA2 mutations were identified (36%) in samples from an affected family member. All mutations segregated with disease where it was possible to check. Of the 14 families fulfilling BCLC criteria, 9 (64%) had mutations whilst only 3/16 (19%) of male breast cancer patients with less significant female breast cancer family history having a mutation. All 3 families with ovarian cancer and 3 families with multiple male breast cancer cases had BRCA2 mutations. These data are a further guide to how to prioritise samples for BRCA2 mutation analysis.
Published: 2001
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38. The mutated human gene encoding hepatocyte nuclear factor 1beta inhibits kidney formation in developing Xenopus embryos.

Author: Wild W, Pogge von Strandmann E, Nastos A, Senkel S, Lingott-Frieg A, Bulman M, Bingham C, Ellard S, Hattersley AT, and Ryffel GU
Subjects: Animals, Embryo, Nonmammalian physiology, Hepatocyte Nuclear Factor 1-beta, Heterozygote, Humans, Mutation, Nephrons embryology, Phenotype, Transfection, Xenopus Proteins, DNA-Binding Proteins genetics, DNA-Binding Proteins physiology, Frameshift Mutation, Kidney embryology, Sequence Deletion, Transcription Factors genetics, Transcription Factors physiology, Xenopus embryology
Abstract: The transcription factor hepatocyte nuclear factor 1beta (HNF1beta) is a tissue-specific regulator that also plays an essential role in early development of vertebrates. In humans, four heterozygous mutations in the HNF1beta gene have been identified that lead to early onset of diabetes and severe primary renal defects. The degree and type of renal defects seem to depend on the specific mutation. We show that the frameshift mutant P328L329fsdelCCTCT associated with nephron agenesis retains its DNA-binding properties and acts as a gain-of-function mutation with increased transactivation potential in transfection experiments. Expression of this mutated factor in the Xenopus embryo leads to defective development and agenesis of the pronephros, the first kidney form of amphibians. Very similar defects are generated by overexpressing in Xenopus the wild-type HNF1beta, which is consistent with the gain-of-function property of the mutant. In contrast, introduction of the human HNF1beta mutant R137-K161del, which is associated with a reduced number of nephrons with hypertrophy of the remaining ones and which has an impaired DNA binding, shows only a minor effect on pronephros development in Xenopus. Thus, the overexpression of both human mutants has a different effect on renal development in Xenopus, reflecting the variation in renal phenotype seen with these mutations. We conclude that mutations in human HNF1beta can be functionally characterized in Xenopus. Our findings imply that HNF1beta not only is an early marker of kidney development but also is functionally involved in morphogenetic events, and these processes can be investigated in lower vertebrates.
Published: 2000
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39. Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta.

Author: Bingham C, Ellard S, Allen L, Bulman M, Shepherd M, Frayling T, Berry PJ, Clark PM, Lindner T, Bell GI, Ryffel GU, Nicholls AJ, and Hattersley AT
Subjects: Abortion, Induced, Adult, Base Sequence genetics, Diabetes Mellitus, Type 2 genetics, Female, Fetus anatomy & histology, Gene Deletion, Hepatocyte Nuclear Factor 1-beta, Humans, Infant, Newborn, Insulin physiology, Islets of Langerhans physiopathology, Kidney Diseases genetics, Male, Pedigree, Polycystic Kidney Diseases diagnostic imaging, Polycystic Kidney Diseases embryology, Polycystic Kidney Diseases genetics, Polycystic Kidney Diseases pathology, Pregnancy, Ultrasonography, Prenatal, DNA-Binding Proteins genetics, Frameshift Mutation genetics, Nephrons growth & development, Transcription Factors genetics
Abstract: Background: The transcription factor hepatocyte nuclear factor (HNF)-1 beta functions as a homodimer or as a heterodimer with the structurally related protein HNF-1 alpha. Both are expressed sequentially in rat kidney development, with HNF-1 beta being detected from the earliest inductory phases. HNF-1 beta gene mutations are associated with a unique disorder characterized by maturity-onset diabetes of the young (MODY) and early-onset and progressive nondiabetic renal dysfunction, which may lead to chronic renal failure., Methods: The HNF-1 beta gene was screened for mutations in six subjects with early-onset diabetes and a history of renal dysfunction in the subjects or their families., Results: A novel frameshift mutation in exon 4 of the HNF-1 beta gene and a deletion of CCTCT at codons 328 to 329 were detected in one subject. She was diagnosed as diabetic at the age of 21 in her second pregnancy. Glucose tolerance rapidly deteriorated over 18 months as a result of beta-cell dysfunction. The HNF-1 beta mutation arose de novo on a paternal chromosome and cosegregated with renal abnormalities in her family. The proband had bilateral small cysts in normal-sized kidneys and a reduced creatinine clearance of 66 mL/min (NR 80-120). Her first pregnancy was terminated at 17 weeks following an ultrasound diagnosis of bilateral, nonfunctioning cystic kidneys. Her first-born child had a small multicystic, dysplastic right kidney and a dysplastic left kidney with a reduced creatinine clearance (40 mL/min per 1.73 m2). Histologic examination of the large (5.8 vs. 1.4 g), polycystic fetal kidneys showed no normal nephrogenesis., Conclusions: These studies indicate that HNF-1 beta plays a central role in normal kidney development and pancreatic beta-cell function, and suggest that one mechanism by which HNF-1 beta gene mutations may cause renal dysfunction are by their effects on nephron development.
Published: 2000
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40. Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree.

Author: Lausen J, Thomas H, Lemm I, Bulman M, Borgschulze M, Lingott A, Hattersley AT, and Ryffel GU
Subjects: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Hepatocyte Nuclear Factor 1, Hepatocyte Nuclear Factor 1-alpha, Hepatocyte Nuclear Factor 1-beta, Hepatocyte Nuclear Factor 4, Humans, Mutagenesis, Site-Directed, Phosphoproteins genetics, Promoter Regions, Genetic, Transcription Factors genetics, Transcriptional Activation, Tumor Cells, Cultured, DNA-Binding Proteins, Nuclear Proteins, Phosphoproteins physiology, Transcription Factors physiology
Abstract: The hepatocyte nuclear factor (HNF)4alpha, a member of the nuclear receptor superfamily, regulates genes that play a critical role in embryogenesis and metabolism. Recent studies have shown that mutations in the human HNF4alpha gene cause a rare form of type 2 diabetes, maturity onset diabetes of the young (MODY1). To investigate the properties of these naturally occurring HNF4alpha mutations we analysed five MODY1 mutations (R154X, R127W, V255M, Q268X and E276Q) and one other mutation (D69A), which we found in HepG2 hepatoma cells. Activation of reporter genes in transfection assays and DNA binding studies showed that the MODY1-associated mutations result in a variable reduction in function, whereas the D69A mutation showed an increased activity on some promoters. None of the MODY mutants acted in a dominant negative manner, thus excluding inactivation of the wild-type factor as a critical event in MODY development. A MODY3-associated mutation in the HNF1alpha gene, a well-known target gene of HNF4alpha, results in a dramatic loss of the HNF4 binding site in the promoter, indicating that mutations in the HNF4alpha gene might cause MODY through impaired HNF1alpha gene function. Based on these data we propose a two-hit model for MODY development.
Published: 2000
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41. Mutations in hepatocyte nuclear factor 1beta are not a common cause of maturity-onset diabetes of the young in the U.K.

Author: Beards F, Frayling T, Bulman M, Horikawa Y, Allen L, Appleton M, Bell GI, Ellard S, and Hattersley AT
Subjects: Adult, Genetic Linkage, Hepatocyte Nuclear Factor 1, Hepatocyte Nuclear Factor 1-alpha, Hepatocyte Nuclear Factor 1-beta, Humans, Sequence Analysis, DNA, United Kingdom, DNA-Binding Proteins, Diabetes Mellitus, Type 2 genetics, Mutation, Nuclear Proteins, Transcription Factors genetics
Published: 1998
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42. Characterization of a cDNA from Arabidopsis thaliana encoding a potential thiol protease whose expression is induced independently by wilting and abscisic acid.

Author: Williams J, Bulman M, Huttly A, Phillips A, and Neill S
Subjects: Amino Acid Sequence, Arabidopsis enzymology, Arabidopsis physiology, Base Sequence, Blotting, Southern, Cold Temperature, Cysteine Endopeptidases chemistry, DNA, Complementary genetics, Hot Temperature, Molecular Sequence Data, Plant Proteins chemistry, RNA, Messenger genetics, RNA, Messenger metabolism, Sequence Analysis, DNA, Water metabolism, Water physiology, Abscisic Acid pharmacology, Arabidopsis genetics, Arabidopsis Proteins, Cysteine Endopeptidases genetics, Gene Expression Regulation, Enzymologic drug effects, Genes, Plant, Plant Proteins genetics
Abstract: The sequence and expression characteristics are described of a wilt-inducible gene in Arabidopsis thaliana. A1494 encodes a potential thiol protease whose mRNA accumulates rapidly in shoot tissue upon the loss of turgor. A1494 mRNA levels peaked after ca. 4 h and declined thereafter. Dehydration also induced rapid biosynthesis of the phytohormone abscisic acid (ABA), which continued for at least 9 h. Exogenous ABA induced the accumulation of A1494 mRNA, with kinetics similar to those after wilting. Rehydration of wilted shoots led to a rapid decline in the content of both ABA and A1494 mRNA. Wilting and ABA independently induced A1494 expression as evidenced by the effects of ABA and wilting on the ABA-deficient aba-1 and ABA-insensitive abi-1 and abi-3 genotypes. A1494 mRNA was not detectable in aba-1 shoots but accumulated rapidly after either wilting or ABA treatment, whereas the shoot ABA content was increased only by ABA treatment. ABA had no effect on A1494 mRNA levels in the abi-1 and abi-3 mutants but wilting did result in enhanced A1494 expression. Heat shock had only a minor effect on A1494 mRNA levels, whereas exposure to low temperature resulted in substantial accumulation of A1494 mRNA in wild-type shoots. However, this latter response, unlike that to drought, was mediated exclusively via ABA synthesis as demonstrated by the lack of A1494 mRNA accumulation in cold-treated aba-1 shoots.
Published: 1994
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