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2. Perceptions of the impact of individual allergic rhinitis symptoms: A survey of ARIA clinical experts

Author

Asllani, Julijana, Douagui, Habib, Asayag, Estrella, Elizabeth, Castro Maria, Crisci, Carlos D., Gomez, René Maximiliano, Ivancevich, Juan Carlos, Jares, Edgardo, Máspero, Jorge Fernando, Moreno, Pablo, Neffen, Hugo Eduardo, Zernotti, Mario Emilio, Bosnic-Anticevich, Sinthia, Chahhoud Carson, Kristin, Cvetkovski, Biljana, Davies, Janet M., Kritikos, Vicky, O'Hehir, Robyn, Oliver, Brian, Tan, House Rachel, Tattersall, Jessica, Zubrinich, Celia, Aberer, Werner, Niederberger-Leppin, Verena, Pali-Schöll, Isabella, Doyen, Virginie, Ebo, Didier, Louis, Renaud, Rombaux, Philippe, Scheire, Sophie, Bennoor, Kazi, Barreto, Bruno A., Camargos, Paulo, Chong-Neto, Herberto Jose, Cruz, Alvaro A., da Silva, Jane, Marta, Guidacci, Rizzo, José Angelo, Rosario Filho, Nelson, Faradiba, Sarquis Serpa, Solé, Dirceu, Urrutia-Pereira, Marilyn, Christoff, George, Mariana, Mandazhieva-Pepelanova, Cvetanka, Odjakova, Popov, Todor A., Vicheva, Dilyana, Teixeira Maria, do Ceu, Bouchard, Jacques, Brozek, Jan, Chu, Derek K., Denburg, Judah, Eiwegger, Thomas, Keith, Paul K., To, Teresa, Waserman, Susan, Abusada, Nancy, Alvarez Cuesta, Emilio, Calvo-Gil, Mario A., Guzmán, Maria Antonieta, Pérez Gomez, Tamara, Wong Gary, Wing Kin, Zhang, Luo, Caraballo, Luis, Cepeda Sarabia, Alfonso, Nyembue, Dieudonné, Soto-Martinez, Manuel, Miculinic, Neven, Plavec, Davor, Pitsios, Constantinos, Yiallouros, Panayiotis, Panzner, Petr, Sova, Milan, Vachova, Martina, Bindslev-Jensen, Carsten, Dahl, Ronald, Malling, Hans-Jorgen, Münter, Lars, Poulsen, Lars K., Charlotte, Suppli Ulrik, Tannert, Line Kring, Mahboub, Bassam, Salameh, Laila, Cherrez-Ojeda, Ivan, Robles, de Guevara Karla, El-Owaidy, Rasha Hassan, El-Sayed, Zeinab A., El-Sayed, Shereen Saad, Hossny, Elham, Mostafa, Badr Eldin, Julge, Kaja, Billo, Nils Eric, Eklund, Patrik, Erhola, Marina, Haahtela, Tari, Karjalainen, Jussi, Makela, Mika, Toppila-Salmi, Sanna, Valovirta, Erkka, Vasankari, Tuula, Annesi-Maesano, Isabella, Bossé, Isabelle, Bourgoin-Heck, Melisande, Charpin, Denis, Coste, André, de Blay, Frédéric, Devillier, Philippe, Didier, Alain, Dinh-Xuan, Anh Tuan, Fontaine, Jean-François, Just, Jocelyne, Nadif, Rachel, Pham-Thi, Nhân, Pigearias, Bernard, Roche, Nicolas, Ganse Eric, Van, Chkhartishvili, Ekaterine, Gamkrelidze, Amiran, Gotua, Maia, Becker, Sven, Bergmann, Karl-Christian, Bieber, Thomas, Brehler, Randolf, Buhl, Roland, Chaker, Adam M., Darsow, Ulf, Hamelmann, Eckard, Heinrich, Joachim, Keil, Thomas, Klimek, Ludger, Kolkhir, Pavel, Lau, Susanne, Maurer, Marcus, Mösges, Ralph, Neou, Angelos, Pfaar, Oliver, Ring, Johannes, Wagenmann, Martin, Zuberbier, Torsten, Ramanauskaite, Aiste, Lingnau, Anja, Christou, Demetrios, Neisinger, Sophia, Aggelidis, Xenophon, Constantinidis, Jannis, Dimou, Maria, Grigoreas, Christos, Kapsali, Trisevgeni, Katotomichelakis, Michael, Loukides, Stelios, Makris, Michael, Manousakis, Emmanouil, Mikos, Nikolaos, Pagkalos, Aris, Papadopoulos, Nikolaos G., Papanikolaou, Vasileios, Paraskevopoulos, Giannis, Piskou, Konstantina, Prokopakis, Emmanuel, Psarros, Fotios, Samitas, Konstantinos, Stamataki, Sofia, Stefanaki Lina, Evangelia, Syrigou, Ekaterini, Tsiligianni, Ioanna, Vallianatou, Mina, Vourdas, Dimitrios, Xepapadaki, Paraskevi, Karavelia, Aspasia, Wai San Ko, Fanny, Wong, Gary, Hirschberg, Andor, Kraxner, Helga, Nekam, Kristof, Lane, Stephen, Rottem, Menachem, Artesani Maria, Cristina, Barbaglia, Simona, Beghé, Bianca, Bilo Maria, Beatrice, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Braido, Fulvio, Brussino, Luisa, Canonica, G Walter, Cecchi, Lorenzo, Ciprandi, Giorgio, Compalati, Enrico, D'Amato, Gennaro, De Feo, Giulia, Del Giacco, Stefano, Fiocchi, Alessandro, Heffler, Enrico, Lombardi, Carlo, Monti, Riccardo, Muraro, Antonella, Nettis, Eustachio, Nicola, Stefania, Passalacqua, Giovanni, Patella, Vincenzo, Puggioni, Francesca, Rolla, Giovanni, Romano, Antonino, Scichilone, Nicola, Triggiani, Massimo, Ventura Maria, Teresa, Viegi, Giovanni, Boccabella, Cristina, Giovannini, Mattia, Mahesh Padukudru, Anand, Iinuma, Tomohisa, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimihiro, Pawankar, Ruby, Sakurai, Daiju, Suzukawa, Maho, Yamaguchi, Masao, Ispayeva, Zhanat, Chang, Yoon-Seok, Park, Hae-Sim, Al-Ahmad, Mona, Cirule, Ieva, Grisle, Ineta, Irani, Carla, Rouadi, Philip, Zaitoun, Fares, Dubakiene, Ruta, Emuzyte, Regina, Kvedariene, Violeta, Gradauskiene, Brigita, Valiulis, Arunas, Ollert, Markus, Hannachi, Farah, Dokic, Dejan, Abdul Latiff, Amir Hamzah, Abdullah, Baharudin, Palaniappan, S.P., Woo, Kent, Montefort, Stephen, Bedolla Barajas, Martín, Costa Domínguez, María del Carmen, Espinoza Contreras, Jesús Guillermo, Fuentes Pèrez, Jose Miguel, Gálvez Romero, José Luis, García Cruz, María de la Luz Hortensia, González Diaz, Sandra, Huerta Villalobos, Yunuen Rocío, Larenas-Linnemann, Désiree E., Luna-Pech, Jorge Agustin, Matta Campos, Juan José, Rivero Yeverino, Daniela, Rodríguez González, Mónica, Rodríguez Zagal, Eréndira, Lkhagvaa, Battur, Mavale-Manuel, Sandra, Nunes Elizabete, Abrantes, Chavannes, Niels, Fokkens, Wytske J., Koppelman, Gerard, Maitland-van der Zee, Anke-Hilse, Reitsma, Sietze, Chandrasekharan, Ramanathan, Yusuf, Osman, Repka-Ramirez, Maria Susana, Sisul, Juan Carlos, Gereda, José E., Recto, Marysia T., Bialek, Slawomir, Bialoszewski, Artur, Chelminska, Marta, Gawlik, Radoslaw, Jassem, Ewa, Jutel, Marek, Kuna, Piotr, Kupczyk, Maciej, Moniuszko, Marcin, Niedoszytko, Marek, Raciborski, Filip, Romantowski, Jan, Samolinski, Boleslaw, Specjalski, Krzysztof, Carreiro Martins, Pedro, Correia de Sousa, Jaime, Costa, Elisio, Fonseca, Joao A., Lourenço, Olga, Morais-Almeida, Mario, Pereira Ana, Margarida, Regateiro, Frederico, Robalo Cordeiro, Carlos, Rosado Pinto, Jose, Sousa-Pinto, Bernardo, Taborda Barata, Luis, Todo-Bom, Ana Maria, Vieira Rafael, José, Carvalho, Daniela, Al-Nesf, Maryam Ali, Agache, Ioana, Berghea Elena, Camelia, Bumbacea, Roxana, Deleanu, Diana, Mihaltan, Florin, Panaitescu Bunu, Carmen, Khaitov, Musa, Namazova-Baranova, Leyla, Vishneva, Elena, Alshaikh Nada, Ali, Dimic-Janjic, Sanja, Milenkovic, Branislava, Wang, De Yun, Hrubiško, Martin, Edelbaher, Natalija, Jošt, Maja, Kopac, Peter, Košnik, Mitja, Lalek, Nika, Poplas Susic, Antonija, Rozman Sinur, Irma, Soklic Košak, Tanja, Triller, Nadja, Triller, Katja, Urbancic, Jure, Zidarn, Mihaela, Levin, Michael, Potter, Paul, Zar, Heather, Alobid, Isam, Anto, Aram, Bartra, Joan, Bobolea, Irina, Campo, Paloma, Cardona, Vicky, Carriazo Ana, Maria, Castillo Vizuete, José Antonio, Chivato, Tomas, Davila Gonzalez, Ignacio Jesus, Mullol, Joaquim, Nieto Garcia, Antonio, Picado, César, Quirce, Santiago, Sastre, Joaquin, de las Vecillas, Leticia, Benson, Mikael, Kull, Inger, van Hage, Marianne, Wickman, Magnus, Khaltaev, Nikolai, Mohammad, Yousser, Tantilipikorn, Pongsakorn, Vichyanond, Pakit, Cingi, Cemal, Gemicioglu, Bilun, Goksel, Ozlem, Kalayci, Omer, Kalyoncu, Ali Fuat, Meço, Cem, Vardaloglu, Koyuncu Ilgim, Yorgancioglu, Arzu, Karabacak, Deniz Eyice, Kirenga, Bruce, Adcock, Ian Michael, Arshad, Hasan S., Bewick, Mike, Bond, Christine, Brightling, Christopher, Bush, Andrew, Calderon, Moïses, Chung, Kian Fan, Custovic, Adnan, Djukanovic, Ratko, Durham, Stephen, Farrell, John, Halpin, David, Hyland, Michael, Johnston, Sebastian, Lipworth, Brian, Nakonechna, Alla, Price, David, Roberts, Graham, Ryan, Dermot, Schwarze, Jürgen, Sheikh, Aziz, Shields, Mike, Walker, Samantha, Williams, Sian, Kaidashev, Igor, Kurchenko, Andrii Igorevich, Tsaryk, Vladyslav, Bernstein, David, Bernstein, Jonathan A., Casale, Thomas B., Chinthrajah, Sharon, Dykewicz, Mark, Marshall, Gailen D., Meltzer, Eli O., Naclerio, Robert M., Togias, Alkis, Toskala, Elina, Wallace, Dana, Williams, Dennis M., Yawn, Barbara, Caballero-Fonseca, Fernan, Le Thi Tuyet, Lan, Vu, Tran Thien Quan, Gil-Mata, Sara, Teixeira, Tatiana, Bedbrook, Anna, Bousquet, Jean, and Vieira, Rafael José

Published
2024
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4. Aeroallergen immunotherapy associated with reduced risk of severe COVID-19 in 1095 allergic patients

Author

Larenas-Linnemann, Désirée, Morfin-Maciel, Blanca María, Bedolla-Barajas, Martín, López-Bago, Ana, Navarrete Rodríguez, Elsy Maureen, Mogica-Martínez, María Dolores, Gereda, José E., Sarrazola Sanjuan, Mauricio, Cano Pedroza, Rosa Yazmín, Cavallo, María Cecilia, Romero Tapia, Sergio de Jesús, Jossen, Roberto A., Fuentes Pérez, José Miguel, Del Rio Navarro, Blanca E., Rodríguez Zagal, Erendira, Piraino Sosa, Pedro A., Huerta Villalobos, Yunuen Rocío, Chavez-Vereau, Pierre, García Imperial, Daniel Alberto, Olivares Gómez, Margarita, Valle Rodríguez, Francisco, Zuñiga Reyes, Carlos Omar, Rodríguez-González, Mónica, Gallego Corella, Claudia Ivonne, Ivancevich, Juan Carlos, García Cruz, María de la Luz Hortencia, Repka-Ramirez, María Susana, Flores Morales, Mauricio Ernesto, Fernández De Córdova Aguirre, Juan Carlos, Luna-Pech, Jorge A., Rivero Yeverino, Daniela, Martínez Guzmán, Edgar, Pérez Ortiz, Cinthia Elizabeth, and Villa Médica, Leonor

Published
2023
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5. Development and validation of an electronic daily control score for asthma (e-DASTHMA): a real-world direct patient data study

Author

Sousa-Pinto, Bernardo, Jácome, Cristina, Pereira, Ana Margarida, Regateiro, Frederico S, Almeida, Rute, Czarlewski, Wienczyslawa, Kulus, Marek, Shamji, Mohamed H, Boulet, Louis-Philippe, Bonini, Matteo, Brussino, Luisa, Canonica, G Walter, Cruz, Alvaro A, Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Louis, Renaud, Niedoszytko, Marek, Pham-Thi, Nhân, Puggioni, Francesca, Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl C, Amaral, Rita, Azevedo, Luís Filipe, Bosnic-Anticevich, Sinthia, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Loureiro, Claudia Chaves, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Jassem, Ewa, Joos, Guy, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Luna Pech, Jorge, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Neffen, Hugo E, Ohta, Ken, Papadopoulos, Nikolaos G, Papi, Alberto, Pétré, Benoit, Pfaar, Oliver, Yeverino, Daniela Rivero, Cordeiro, Carlos Robalo, Roche, Nicolas, Sá-Sousa, Ana, Samolinski, Boleslaw, Sheikh, Aziz, Ulrik, Charlotte Suppli, Usmani, Omar S, Valiulis, Arunas, Vandenplas, Olivier, Vieira-Marques, Pedro, Yorgancioglu, Arzu, Zuberbier, Torsten, Anto, Josep M, Fonseca, João A, and Bousquet, Jean

Published
2023
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8. Compromising between European and US allergen immunotherapy schools: Discussions from GUIMIT, the Mexican immunotherapy guidelines

Author

Larenas-Linnemann, Désirée, Rodríguez-Pérez, Noel, Luna-Pech, Jorge A., Rodríguez-González, Mónica, Blandón-Vijil, María Virginia, Del-Río-Navarro, Blanca E., Costa-Domínguez, María del Carmen, Navarrete-Rodríguez, Elsy Maureen, Macouzet-Sánchez, Carlos, Ortega-Martell, José Antonio, Pozo-Beltrán, César Fireth, Estrada-Cardona, Alan, Arias-Cruz, Alfredo, Rodríguez Galván, Karen Guadalupe, Brito-Díaz, Herson, Canseco-Raymundo, María del Rosario, Castelán-Chávez, Enrique Emanuel, Escalante-Domínguez, Alberto José, Gálvez-Romero, José Luis, Gómez-Vera, Javier, González-Díaz, Sandra Nora, Guerrero-Núñez, María Gracia Belinda, Hernández-Colín, Dante Daniel, Macías-Weinmann, Alejandra, Mendoza-Hernández, David Alejandro, Meneses-Sánchez, Néstor Alejandro, Mogica-Martínez, María Dolores, Moncayo-Coello, Carol Vivian, Montiel-Herrera, Juan Manuel, O'Farril-Romanillos, Patricia María, Onuma-Takane, Ernesto, Ortega-Cisneros, Margarita, Rangel-Garza, Lorena, Stone-Aguilar, Héctor, Torres-Lozano, Carlos, Venegas-Montoya, Edna, Wakida-Kusunoki, Guillermo, Partida-Gaytán, Armando, López-García, Aída Inés, Macías-Robles, Ana Paola, Ambriz-Moreno, María de Jesús, Azamar-Jácome, Amyra Ali, Beltrán-De Paz, Claudia Yusdivia, Caballero-López, Chrystopherson, Fernández de Córdova-Aguirre, Juan Carlos, Fernández-Soto, José Roberto, Lozano-Sáenz, José Santos, Oyoqui-Flores, José Joel, Osorio-Escamilla, Roberto Efrain, Ramírez-Jiménez, Fernando, Rivero-Yeverino, Daniela, Martínez Infante, Eric, and Medina-Ávalos, Miguel Alejandro

Published
2020
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9. An online survey detected knowledge gaps and cost-saving opportunities in asthma maintenance treatment among allergists, pulmonologists, ENTs and primary care

Author

Larenas-Linnemann, Désirée, Fernández-Vega, Margarita, Rodríguez-González, Mónica, Cano-Salas, María del Carmen, Luna-Pech, Jorge Agustín, Ortega-Martell, José Antonio, Del Rio-Navarro, Blanca, López-Estrada, Erika del Carmen, Romero-Lombard, Jade, Vázquez-García, Juan Carlos, and Salas-Pérez, Jorge

Published
2019
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10. Changes in Skin Test Aeroallergen Sensitization in Mexico Over the Past 14 Years and According to Climate.

Author

Larenas-Linnemann, Désirée, Morfín-Maciel, Blanca María, Gonzalez-Uribe, Victor, Gallego-Corella, Claudia Ivonne, Rico-Solís, Germán Agustín, Hernández-Velázquez, Luiana, García-Imperial, Daniel, Caballero-Lopez, Chrystopherson Gengyny, Garibay-Vargas, Ondina Marlene, Gálvez-Romero, José Luis, Fajardo, Daniela García, Barroso-Santos, Joel, de Jesús Pérez-Áviles, Herberth, Luna-Pech, Jorge Agustín, García-Cobas, Cecilia Yvonne, Coronado-Hernández, Kareli Guadalupe, Ortega-Cisneros, Margarita, González-Gutiérrez, Carlos Humberto, Rivero-Yeverino, Daniela, and Navarrete-Rodríguez, Elsy Maureen

Subjects
SKIN tests, CITIES & towns, ALLERGIC rhinitis, RESPIRATORY allergy, DERMATOPHAGOIDES
Abstract

Introduction: Aeroallergen exposure has an intra- and extra-domiciliary component and varies according to climatological zones. Mexico is a large country with a great variety of climates. A previous study (2009) evaluated skin prick test results (SPT) in different regions. In this study, we compare previous sensitization patterns from 14y ago with current ones and compare them between different climatological zones. Methods: Mexican allergists were asked to share their last 100 SPT results in patients with respiratory allergy. Clinics were grouped in (semi)humid vs (semi)dry zones. Results were analyzed nationwide and compared to the 2009 results, calculating odds ratio (OR) and 95% confidence intervals (95% CIs), with p < 0.05 as cut-off. Similarly, we compared (semi)humid versus dry zones. Results: We collected 2915 SPT results from 28 clinics (19 cities). Dermatophagoides was the most frequently sensitizing allergen. There was a significant increase in SPT positivity from 2009 to 2023 in both in- and outdoor aeroallergens (OR 1.26– 2.65, 95% CI from 1.06– 1.50 to 1.99– 3.52). Comparing dry-humid zones, sensitization to pollen from Oleaceae, Fagaceae (p < 0.0001 all) and most weeds is more frequent in humid zones, as are Dermatophagoides and cockroach (both p < 0.0001). Eucalyptus, mesquite, and all grass pollen sensitizations predominate in dry zones (p < 0.05– 0.0001). There are no differences in sensitization to cat or dog between zones. Conclusion: We found a general increase in SPT sensitization over the past fourteen years, suggesting that this is probably not only due to climate change. The different sensitization profile throughout the country was mainly related to humidity. Repeating epidemiologic SPT studies over the years could help tracking changes in allergen sensitization over time. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Pediatric asthma treatment: What to do when international guideline recommendations do not agree

Author

Larenas Linnemann, Désirée E.S., Fernández Vega, Margarita, Luna Pech, Jorge Agustín, Villaverde Rosas, Jimena, Ortega Martell, José Antonio, del Río Navarro, Blanca Estela, Cano Salas, María del Carmen, Romero Lombard, Jade, López Estrada, Erika del Carmen, Rodriguez-González, Monica, Mayorga Butrón, José Luis, Salas Hernández, Jorge, Vázquez García, Juan Carlos, Ortiz Aldana, Ignacio, Vargas Becerra, Mario Humberto, Bedolla Barajas, Martín, Rodríguez Pérez, Noel, Aguilar Aranda, Ambrocio, Jiménez González, Carlos Adrián, García Bolaños, Carlos, Garrido Galindo, Claudia, Mendoza Hernández, David Alejandro, Mendoza López, Enrique, López Pérez, Gerardo, Wakida Kuzonoki, Guillermo Hideo, Ruiz Gutiérrez, Héctor Hernán, León Molina, Héctor, Martínez de la Lanza, Héctor, Stone Aguilar, Héctor, Gómez Vera, Javier, Olvera Salinas, Jorge, Oyoqui Flores, José Joel, Gálvez Romero, José Luis, Lozano Saenz, José Santos, Salgado Gama, Juan Ignacio, Jiménez Chobillon, Marcos Alejandro, García Avilés, Martha Angélica, Guinto Balanzar, Martha Patricia, Medina Ávalos, Miguel Alejandro, Camargo Angeles, Robert, García Torrentera, Rogelio, Toral Freyre, Saraí, Montes Narvaez, Gabriel, Solorio Gómez, Héctor, Rosas Peña, Juan, Romero Tapia, Sergio Jesús, Reyes Herrera, Adela, Cuevas Schacht, Francisco, Esquer Flores, Joaquín, Sacre Hazouri, José Antonio, Compean Martínez, Lorenzo, Medina Sánchez, Pablo Julián, Garza Salinas, Sergio, Baez Loyola, Carlos, Romero Alvarado, Iraís, Miguel Reyes, José Luis, Huerta Espinosa, Laura Elizabeth, Correa Flores, Manuel Ángel, and Castro Martínez, Ricardo

Published
2018
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12. Cutaneous Manifestations Related to COVID-19 Immune Dysregulation in the Pediatric Age Group

Author

Larenas-Linnemann, Désirée, Luna-Pech, Jorge, Navarrete-Rodríguez, Elsy M., Rodríguez-Pérez, Noel, Arias-Cruz, Alfredo, Blandón-Vijil, María Virginia, Del Rio-Navarro, Blanca E., Estrada-Cardona, Alan, Onuma-Takane, Ernesto, Pozo-Beltrán, Cesar Fireth, Valencia-Herrera, Adriana María, Ortiz-Aldana, Francisco Ignacio, and Toledo-Bahena, Mirna Eréndira

Published
2021
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15. An independent in‐depth analysis proposing adjusted Global Initiative on Asthma Step 1–2 treatment suggestions.

Author

Larenas‐Linnemann, Désirée, Navarrete‐Rodríguez, Elsy Maureen, Luna‐Pech, Jorge A., Benítez, Rosaura, Cano‐Salas, Maria Carmen, Del Rio‐Navarro, Blanca E., García‐Ramírez, Ulises Noel, Gochicoa, Laura, López‐Estrada, Erika del Carmen, Ortega‐Martell, José Antonio, and Salas Hernández, Jorge

Subjects
ASTHMA, FORMOTEROL, AGE groups
Abstract

The Global Initiative on Asthma (GINA) strategy included major changes for the treatment of mild asthma in the 2020 version that are even taken to the next level in 2021, leaving a preferred track with only rescue therapy with inhaled corticosteroid and formoterol (ICS‐FORM) for steps 1–2 in 12+ years old. It has been questioned how solid the evidence behind these recommendations is. We decided to independently conduct an in‐depth analysis of published evidence based on a comprehensive evaluation of original articles and related appendices and publications, including quality of evidence and risk of bias per article. We first defined the major asthma treatment goals and proceeded to review how these were met in publications referenced in the main asthma guidelines. For patients with GINA (2021) Step 1 characteristics, the analysis supports GINA's decision to avoid SABA monotherapy and to prefer ICS‐FORM rescue with an alternative ICS rescue every time a SABA is used for ≥12 years, even though evidence is extrapolated from step 2 patients. For 6‐ to 11‐year‐olds, we propose to consider ICS‐FORM rescue as an alternative, as its use has been approved in this age group, be it not as rescue medication. For patients with GINA 2021 Step 2 characteristics, our proposal slightly differs from GINA 2021. We propose to continue avoiding the separate use of SABA, using ICS rescue whenever a fast‐acting bronchodilator is taken (even with ICS maintenance). Also, the superiority of ICS‐FORM rescue over classical step 2 treatment is not uniform and year‐long experience is lacking. Consequently, for now, both treatment options seem equal: ICS‐FORM rescue or ICS maintenance with SABA (+ICS) rescue. For 6‐ to 11‐year‐olds, ICS rescue every time a SABA is used has the advantage of lower total ICS dose; as alternative we suggest ICS‐FORM rescue. The best treatment option depends on patient characteristics and treatment goals. Recommendations should be reviewed as soon as new evidence becomes available. [ABSTRACT FROM AUTHOR]

Published
2022
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17. Coronavirus disease 2019, allergic diseases, and allergen immunotherapy: Possible favorable mechanisms of interaction.

Author

Larenas-Linnemann, Désirée E., Ortega-Martell, José A., Blandón-Vijil, María V., Rodríguez-Pérez, Noel, Luna-Pech, Jorge A., Estrada-Cardona, Alan, Arias-Cruz, Alfredo, Rio-Navarro, Blanca E. Del, Rodríguez, Elsy M. Navarrete, Pozo-Beltrán, Cesar F., Takane, Ernesto Onuma, Rojo-Gutiérrez, María I., Espinosa-Rosales, Francisco J., and Martínez-Infante, Eric A.

Subjects
COVID-19, ALLERGIES, MEDICAL personnel, COVID-19 pandemic, SARS-CoV-2
Abstract

Background: Both, allergen immunotherapy (AIT) and SARS-COV-2 infection cause a set of immunologic changes that respectively vary during the course of the treatment or the disease. Objective: To review immune changes brought along by each of these entities and how they might interrelate. Methods: We start presenting a brief review of the structure of the new coronavirus and how it alters the functioning of the human immune system. Subsequently, we describe the immune changes induced by AIT and how these changes could be favorable or unfavorable in the allergic patient infected with SARS-CoV-2 at a particular point of time during the evolving infection. Results: We describe how a healthy immune response against SARS-CoV-2 develops, versus an immune response that is initially suppressed by the virus, but ultimately overactivated, leading to an excessive production of cytokines (cytokine-storm-like). These changes are then linked to the clinical manifestations and outcomes of the patient. Reviewing the immune changes secondary to AIT, it becomes clear how AIT is capable of restoring a healthy innate immunity. Investigators have previously shown that the frequency of respiratory infections is reduced in allergic patients treated with AIT. On the other hand it also increases immunoregulation. Conclusion: As there are many variables involved, it is hard to predict how AIT could influence the allergic patient's reaction to a SARS-CoV-2 infection. In any case, AIT is likely to be beneficial for the patient with allergic rhinitis and/or allergic asthma in the context of the SARS-CoV-2 pandemic as controlling allergic diseases leads to a reduced need for contact with healthcare professionals. The authors remind the reader that everything in this article is still theoretical, since at the moment, there are no published clinical trials on the outcome of COVID-19 in allergic patients under AIT. [ABSTRACT FROM AUTHOR]

Published
2021
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18. Flowdiagram of development GUIMA México 2017

Author

Linnemann, Désirée Larenas, Salas, María Del Carmen Cano, Vega, Margarita Fernández, Luna-Pech, Jorge, Vázquez-García, Juan Carlos, Salas-Hernández, Jorge, Estrada, Erika López, Lombard, Jade Romero, Ortega-Martell, José Antonio, Del-Rio-Navarro, Blanca, and Mayorga-Butrón, Jose Luis

Published
2018
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23. Logistic precautions in preparation and administration of allergen immunotherapy during the COVID-19 pandemic in Mexico.

Author

Larenas-Linnemann, Désirée, Del Río-Navarro, Blanca E., Luna-Pech, Jorge, Navarrete-Rodríguez, Elsy M., Pozo-Beltrán, César Fireth, Arias-Cruz, Alfredo, Costa-Domínguez, María del Carmen, Rodríguez-González, Mónica, Blandón-Vijil, María Virginia, Estrada-Cardona, Alan, Gereda, José E., Ortega-Martell, José Antonio, Rodríguez-Pérez, Noel, Rojo-Gutiérrez, María Isabel, Espinosa-Rosales, Francisco Javier, and Martínez-Infante, Eric A.

Published
2020
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26. Normocaloric Diet Improves Asthma-Related Quality of Life in Obese Pubertal Adolescents.

Author

Luna-Pech, Jorge agustin, Torres-Mendoza, Blanca Miriam, Luna-Pech, Jose antonio, Garcia-Cobas, Cecilia Yvonne, Navarrete-Navarro, Susana, and Elizalde-Lozano, alejandro Manuel

Subjects
*DIET, *ASTHMA, *QUALITY of life, *TEENAGERS, *OBESITY, *ADRENOCORTICAL hormones
Abstract

Background: Restrictive, very low-energy diets focused on rapid weight loss have proven to be effective in improving asthma outcome in obese patients, but their use in children and pubescents is controversial due its potential consequences in growth. More conservative, normocaloric schemes are suggested as a more suitable dietary approach for these patients. Methods: A randomized clinical trial was run of 51 pubertal adolescents with asthma and obesity, who were allocated to either an interventional 28-week program of normocaloric diet based on normal requirements for height and meal planning (n = 26) or a non-interventional (free diet) control group (n = 25). Asthma-related quality of life (AR-QOL, assessed by the Standardized Pediatric Asthma Quality of Life Questionnaire, PAQLQ[S]) and clinical indicators of asthma control were measured before and after the intervention period. Results: Diet intervention was associated with a significant improvement in AR-QOL in relation to baseline (Δ PAQLQ[S] scores) compared with controls, both in overall score (p < 0.001) and its subdomains (activity limitation, p < 0.001; symptoms, p < 0.002; emotional function, p < 0.001). The group with normocaloric diet observed a significant decrease in body mass index z-score, which correlated positively with the improvement in AR-QOL (Spearman's r = 0.51, p < 0.01), in addition to have significantly fewer events of acute attacks of asthma and nighttime awakenings, plus a non-significant reduction in the use of inhaled corticosteroids. No significant changes were observed in the pulmonary function tests. Conclusion: The normocaloric dietary intervention was associated with improvement of AR-QOL and some aspects of asthma control. Such structured dietary programs could probably have a role as a complementary non-pharmacological therapeutic strategy in obese pubertal adolescents with asthma. © 2014 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2014
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27. In the (sub)tropics Allergic Rhinitis and Its Impact on Asthma classification of allergic rhinitis is more useful than perennial-seasonal classification.

Author

Larenas-Linnemann, Désirée, Michels, Alexandra, Dinger, Hanna, Arias-Cruz, Alfredo, Ambriz Moreno, Marichuy, Bedolla Barajas, Martin, Javier, Ruth Cerino, Cid del Prado, Maria de la Luz, Cruz Moreno, Manuel Alejandro, Vergara, Laura Diego, García Almaráz, Roberto, García-Cobas, Cecilia Y., Garcia Imperial, Daniel Alberto, Muñoz, Rosa Garcia, Hernandez Colín, Dante, Linares Zapien, Francisco Javier, Luna Pech, Jorge Agustín, Matta Campos, Juan Jose, Martinez Jimenez, Norma, and Avalos, Miguel Medina

Subjects
HAY fever treatment, ASTHMA, CLINICAL trials, SENSITIZATION (Neuropsychology), DERMATOPHAGOIDES pteronyssinus, HUMAN phenotype
Abstract

Background: Two different allergic rhinitis (AR) symptom phenotype classifications exist. Treatment recommendations are based on intermittent-persistent (INT-PER) cataloging, but clinical trials still use the former seasonal AR-perennial AR (SAR-PAR) classification. This study was designed to describe how INT-PER, mild-moderate/severe and SAR-PAR of patients seen by allergists are distributed over the different climate zones in a (sub)tropical country and how these phenotypes relate to allergen sensitization patterns. Methods: Six climate zones throughout Mexico were determined, based on National Geographic Institute (Instituto Nacional de Estadística y Geografía) data. Subsequent AR patients (2-68 years old) underwent a blinded, standardized skin-prick test and filled out a validated questionnaire phenotyping AR. Results: Five hundred twenty-nine subjects participated in this study. In the tropical zone with 87% house-dust mite sensitization, INT (80.9%; p < 0.001) and PAR (91%; p = 0.04) were more frequent than in the subtropics. In the central high-pollen areas, there was less moderate/severe AR (65.5%; p < 0.005). Frequency of comorbid asthma showed a clear north-south gradient, from 25% in the dry north to 59% in the tropics (p < 0.005). No differences exist in AR cataloging among patients with different sensitization patterns, with two minor exceptions (more PER in tree sensitized and more PAR in mold positives; p < 0.05). Conclusion: In a (sub)tropical country the SAR-PAR classification seems of limited value and bears poor relation with the INT-PER classification. INT is more frequent in the tropical zone. Because PER has been shown to relate to AR severity, clinical trials should select patients based on INT-PER combined with the severity cataloging because these make for a better treatment guide than SAR-PAR. [ABSTRACT FROM AUTHOR]

Published
2014
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28. Allergen sensitization linked to climate and age, not to intermittent-persistent rhinitis in a cross-sectional cohort study in the (sub)tropics.

Author

Larenas-Linnemann D, Michels A, Dinger H, Shah-Hosseini K, Mösges R, Arias-Cruz A, Ambriz-Moreno M, Barajas MB, Javier RC, de la Luz Cid Del Prado M, Moreno MA, Almaráz RG, García-Cobas CY, Garcia Imperial DA, Muñoz RG, Hernández-Colín D, Linares-Zapien FJ, Luna-Pech JA, Matta-Campos JJ, Jiménez NM, Medina-Ávalos MA, Hernández AM, Maldonado AM, López DN, Pizano Nazara LJ, Sanchez ER, Ramos-López JD, Rodríguez-Pérez N, and Rodríguez-Ortiz PG

Abstract

Background: Allergen exposure leads to allergen sensitization in susceptible individuals and this might influence allergic rhinitis (AR) phenotype expression. We investigated whether sensitization patterns vary in a country with subtropical and tropical regions and if sensitization patterns relate to AR phenotypes or age., Methods: In a national, cross-sectional study AR patients (2-70 y) seen by allergists underwent blinded skin prick testing with a panel of 18 allergens and completed a validated questionnaire on AR phenotypes., Results: 628 patients were recruited. The major sensitizing allergen was house dust mite (HDM) (56%), followed by Bermuda grass (26%), ash (24%), oak (23%) and mesquite (21%) pollen, cat (22%) and cockroach (21%). Patients living in the tropical region were almost exclusively sensitized to HDM (87%). In the central agricultural zones sensitization is primarily to grass and tree pollen. Nationwide, most study subjects had perennial (82.2%), intermittent (56.5%) and moderate-severe (84.7%) AR. Sensitization was not related to the intermittent-persistent AR classification or to AR severity; seasonal AR was associated with tree (p < 0.05) and grass pollen sensitization (p < 0.01). HDM sensitization was more frequent in children (0-11 y) and adolescents (12-17 y) (subtropical region: p < 0.0005; tropical region p < 0.05), but pollen sensitization becomes more important in the adult patients visiting allergists (Adults vs children + adolescents for tree pollen: p < 0.0001, weeds: p < 0.0005)., Conclusions: In a country with (sub)tropical climate zones SPT sensitization patterns varied according to climatological zones; they were different from those found in Europe, HDM sensitization far outweighing pollen allergies and Bermuda grass and Ash pollen being the main grass and tree allergens, respectively. Pollen sensitization was related to SAR, but no relation between sensitization and intermittent-persistent AR or AR severity could be detected. Sensitization patterns vary with age (child HDM, adult pollen). Clinical implications of our findings are dual: only a few allergens -some region specific- cover the majority of sensitizations in (sub)tropical climate zones. This is of major importance for allergen manufacturers and immunotherapy planning. Secondly, patient selection in clinical trials should be based on the intermittent-persistent and severity classifications, rather than on the seasonal-perennial AR subtypes, especially when conducted in (sub)tropical countries.

Published
2014
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