Search

Your search keyword '"Luis Macías-Kauffer"' showing total 10 results
Start Over Author "Luis Macías-Kauffer" Language english
10 results on '"Luis Macías-Kauffer"'

1. Selection scan in Native Americans of Mexico identifies FADS2 rs174616: Evidence of gene-diet interactions affecting lipid levels and Delta-6-desaturase activity

Author

Sandra Romero-Hidalgo, Janine Sagaceta-Mejía, Marisela Villalobos-Comparán, María Elizabeth Tejero, Mayra Domínguez-Pérez, Leonor Jacobo-Albavera, Rosalinda Posadas-Sánchez, Gilberto Vargas-Alarcón, Carlos Posadas-Romero, Luis Macías-Kauffer, Felipe Vadillo-Ortega, Miguel Angel Contreras-Sieck, Víctor Acuña-Alonzo, Rodrigo Barquera, Gastón Macín, Aristea Binia, Jose Guadalupe Guevara-Chávez, Leticia Sebastián-Medina, Martha Menjívar, Samuel Canizales-Quinteros, Alessandra Carnevale, and Teresa Villarreal-Molina

Subjects
Positive selection, FADS gene cluster, Cardiometabolic traits, Mexican GEA cohort, Genotype-related effects of PUFA trial, Ω-3 and Ω-6 polyunsaturated fatty acids, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Searching for positive selection signals across genomes has identified functional genetic variants responding to environmental change. In Native Americans of Mexico, we used the fixation index (Fst) and population branch statistic (PBS) to identify SNPs suggesting positive selection. The 103 most differentiated SNPs were tested for associations with metabolic traits, the most significant association was FADS2/rs174616 with body mass index (BMI). This variant lies within a linkage disequilibrium (LD) block independent of previously reported FADS selection signals and has not been clearly associated with metabolic phenotypes. We tested this variant in two independent cohorts with cardiometabolic data. In the Genetics of Atherosclerotic Disease (GEA) cohort, the derived allele (T) was associated with increased BMI, lower LDL-C levels and a decreased risk of subclinical atherosclerosis in women. Significant gene-diet interactions affected lipid, apolipoprotein and adiponectin levels with differences according to sex, involving mainly total and complex dietary carbohydrate%. In the Genotype-related Effects of PUFA trial, the derived allele was associated with lower Δ-6 desaturase activity and erythrocyte membrane dihomo-gamma-linolenic acid (DGLA) levels, and with increased Δ-5 desaturase activity and eicosapentaenoic acid levels. This variant interacted with dietary carbohydrate% affecting Δ-6 desaturase activity. Notably, the relationship of DGLA and other erythrocyte membrane LC-PUFA indices with HOMA-IR differed according to rs174616 genotype, which has implications regarding how these indices should be interpreted. In conclusion, this observational study identified rs174616 as a signal suggesting selection in an independent linkage disequilibrium block, was associated with cardiometabolic and erythrocyte measurements of LC-PUFA in two independent Mexican cohorts and showed significant gene-diet interactions.

Published
2024
Full Text
View/download PDF

2. An Amino Acid Signature Associated with Obesity Predicts 2-Year Risk of Hypertriglyceridemia in School-Age Children

Author

Sofia Moran-Ramos, Elvira Ocampo-Medina, Ruth Gutierrez-Aguilar, Luis Macías-Kauffer, Hugo Villamil-Ramírez, Blanca E. López-Contreras, Paola León-Mimila, Joel Vega-Badillo, Roxana Gutierrez-Vidal, Ricardo Villarruel-Vazquez, Erandi Serrano-Carbajal, Blanca E Del-Río-Navarro, Adriana Huertas-Vázquez, Teresa Villarreal-Molina, Isabel Ibarra-Gonzalez, Marcela Vela-Amieva, Carlos A. Aguilar-Salinas, and Samuel Canizales-Quinteros

Subjects
Medicine, Science
Abstract

Abstract Childhood obesity is associated with a number of metabolic abnormalities leading to increased cardiovascular risk. Metabolites can be useful as early biomarkers and new targets to promote early intervention beginning in school age. Thus, we aimed to identify metabolomic profiles associated with obesity and obesity-related metabolic traits. We used data from the Obesity Research Study for Mexican children (ORSMEC) in Mexico City and included a case control (n = 1120), cross-sectional (n = 554) and a longitudinal study (n = 301) of 6–12-year-old children. Forty-two metabolites were measured using electrospray MS/MS and multivariate regression models were used to test associations of metabolomic profiles with anthropometric, clinical and biochemical parameters. Principal component analysis showed a serum amino acid signature composed of arginine, leucine/isoleucine, phenylalanine, tyrosine, valine and proline significantly associated with obesity (OR = 1.57; 95%CI 1.45–1.69, P = 3.84 × 10−31) and serum triglycerides (TG) (β = 0.067, P = 4.5 × 10−21). These associations were validated in the cross-sectional study (P

Published
2017
Full Text
View/download PDF

3. Effect of Gut Microbial Enterotypes on the Association between Habitual Dietary Fiber Intake and Insulin Resistance Markers in Mexican Children and Adults

Author

Nimbe Torres, Samuel Canizales-Quinteros, Paola León-Mimila, Blanca E. López-Contreras, Carlos A. Aguilar-Salinas, Francisco J. Gómez-Pérez, Luis Macías-Kauffer, Sofia Moran-Ramos, Omar Granados-Portillo, Hugo Villamil-Ramírez, Jennifer N. Martinez-Medina, Daniela Guzman-Muñoz, Blanca E. Del-Rio-Navarro, Armando R. Tovar, and Regina Flores-Lopez

Subjects
Adult, Male, Adolescent, medicine.medical_treatment, school-age children, Physiology, Gut flora, Diet Surveys, Article, HOMA-IR, Eating, Feces, Young Adult, Insulin resistance, RNA, Ribosomal, 16S, Prevotella, medicine, adults, Humans, TX341-641, Child, Mexico, Metabolic health, Nutrition and Dietetics, biology, gut microbiota, Nutrition. Foods and food supply, Insulin, hemicellulose, Middle Aged, biology.organism_classification, medicine.disease, dietary fiber, insoluble fiber, Gastrointestinal Microbiome, Cross-Sectional Studies, Phenotype, Female, Enterotype, Dietary fiber, Insulin Resistance, enterotypes, Biomarkers, Food Science
Abstract

Dietary fiber (DF) is a major substrate for the gut microbiota that contributes to metabolic health. Recent studies have shown that diet–metabolic phenotype effect might be related to individual gut microbial profiles or enterotypes. Thus, the aim of this study was to examine whether microbial enterotypes modify the association between DF intake and metabolic traits. This cross-sectional study included 204 children (6–12 years old) and 75 adults (18–60 years old). Habitual DF intake was estimated with a Food Frequency Questionnaire and biochemical, clinical and anthropometric data were obtained. Gut microbiota was assessed through 16S sequencing and participants were stratified by enterotypes. Correlations adjusting for age and sex were performed to test the associations between dietary fiber components intake and metabolic traits. In children and adults from the Prevotella enterotype, a nominal negative correlation of hemicellulose intake with insulin and HOMA-IR levels was observed (p &lt, 0.05), while in individuals of the other enterotypes, these associations were not observed. Interestingly, the latter effect was not related to the fecal short-chain-fatty acids profile. Our results contribute to understanding the enterotype influence on the diet–phenotype interaction, which ultimate could provide evidence for their use as potential biomarkers for future precision nutrition strategies.

Published
2021
Full Text
View/download PDF

4. A Multi-Omic Analysis for Low Bone Mineral Density in Postmenopausal Women Suggests a RELATIONSHIP between Diet, Metabolites, and Microbiota

Author

Berenice Rivera-Paredez, Marcela Vela-Amieva, Berenice Palacios-González, Isabel Ibarra-González, Samuel Canizales-Quinteros, Manuel Quiterio, Sofia Moran-Ramos, Luis Macías-Kauffer, Rafael Velázquez-Cruz, Jorge Salmerón, Edgar Denova-Gutiérrez, Yvonne N Flores, and Eric G. Ramírez-Salazar

Subjects
0301 basic medicine, Microbiology (medical), musculoskeletal diseases, intestinal microbiota, medicine.medical_specialty, Aging, vitamin D deficiency, postmenopausal women, 030209 endocrinology & metabolism, Gut flora, Microbiology, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Valine, Virology, Internal medicine, Complementary and Integrative Health, medicine, Vitamin D and neurology, bone health, lcsh:QH301-705.5, Nutrition, Bone mineral, biology, Prevention, biology.organism_classification, medicine.disease, lycopene, Lycopene, 030104 developmental biology, Endocrinology, chemistry, lcsh:Biology (General), estrogen deficiency, inflammation, Osteoporosis, Bacteroides, Leucine, bone mineral density
Abstract

The effect of microbiota composition and its health on bone tissue is a novel field for research. However, their associations with bone mineral density (BMD) have not been established in postmenopausal women. The present study investigates the relation of diet, the microbiota composition, and the serum metabolic profile in postmenopausal women with normal-BMD or with low-BMD. Ninety-two Mexican postmenopausal women were classified into normal-BMD (n = 34) and low-BMD (n = 58). The V4 hypervariable region was sequenced using the Miseq platform. Serum vitamin D was determined by chemiluminescence immunoassay. Serum concentrations of acyl-carnitines and amino acids were determined by electrospray tandem mass spectrometry. Diet was assessed by a food frequency questionnaire. The low-BMD group had fewer observed species, higher abundance of &gamma, Proteobacteria, lower consumption of lycopene, and lower concentrations of leucine, valine, and tyrosine compared with the normal-BMD group. These amino acids correlated positively with the abundance of Bacteroides. Lycopene consumption positively correlated with Oscillospira and negatively correlated with Pantoea genus abundance. Finally, the intestinal microbiota of women with vitamin D deficiency was related to Erysipelotrichaceae and Veillonellaceae abundance compared to the vitamin D non-deficient group. Associations mediated by the gut microbiota between diet and circulating metabolites with low-BMD were identified.

Published
2020

5. Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population

Author

Maricela García-Lechuga, Carla Gallo, Monica Escamilla-Tilch, José Flores-Rivera, Víctor Hugo Tovar-Méndez, María Teresa Villarreal-Molina, Bárbara Antuna-Puente, Verónica Rivas-Alonso, Sandra Romero-Hidalgo, Maria Cátira Bortolini, Tatiana Lebedeva, Juan Daniel García-Rodríguez, Jorge Luis Guerrero-Camacho, Francisco Rothhammer, Hanna Pacheco-Ubaldo, Samuel Canizales-Quinteros, Gabriel Bedoya, Edmond J. Yunis, S. M. Alosco, Victor Acuña-Alonzo, Graciela Ordoñez, Rodrigo Barquera, Luis Macías-Kauffer, Carolina Gonzalez-Torres, Marisela Villalobos-Comparán, Rolando González-José, Julio Granados, Teresa Corona, Sandra Rosas-Madrigal, Neng Yu, Irene Treviño-Frenk, Jair Fernando Ortiz-Maldonado, and Andres Ruiz-Linares

Subjects
0301 basic medicine, Male, LATINOAMERICANOS, Science, Genetic genealogy, Population, Immunology, Genome-wide association study, Human leukocyte antigen, Biology, MESTIZAJE, Article, MEXICO, 03 medical and health sciences, 0302 clinical medicine, Medical research, NEUROMIELITIS OPTICA, Gene Frequency, HLA Antigens, medicine, Genetics, Humans, Genetic Predisposition to Disease, Allele, education, Allele frequency, Mexico, American Indian or Alaska Native, Aquaporin 4, education.field_of_study, Multidisciplinary, Neuromyelitis optica, Neuromyelitis Optica, Case-control study, purl.org/becyt/ford/3.1 [https], medicine.disease, purl.org/pe-repo/ocde/ford#3.01.03 [https], purl.org/pe-repo/ocde/ford#3.01.02 [https], 030104 developmental biology, Risk factors, Case-Control Studies, Medicine, purl.org/becyt/ford/3 [https], Female, 030217 neurology & neurosurgery
Abstract

Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10–6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10–10). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America. Fil: Romero Hidalgo, Sandra. Instituto Nacional de Medicina Genómica; México Fil: Flores Rivera, José. Instituto Nacional de Neurología y Neurocirugía; México Fil: Rivas Alonso, Verónica. Instituto Nacional de Neurología y Neurocirugía; México Fil: Barquera, Rodrigo. Max Planck Institute For The Science Of Human History; Alemania. Instituto Nacional de Antropología e Historia; México Fil: Villarreal Molina, María Teresa. Instituto Nacional de Medicina Genómica; México Fil: Antuna Puente, Bárbara. Instituto Nacional de Medicina Genómica; México Fil: Macias Kauffer, Luis Rodrigo. Universidad Nacional Autónoma de México; México Fil: Villalobos Comparán, Marisela. Instituto Nacional de Medicina Genómica; México Fil: Ortiz Maldonado, Jair. Instituto Nacional de Neurología y Neurocirugía; México Fil: Yu, Neng. American Red Cross; Estados Unidos Fil: Lebedeva, Tatiana V.. American Red Cross; Estados Unidos Fil: Alosco, Sharon M.. American Red Cross; Estados Unidos Fil: García Rodríguez, Juan Daniel. Instituto Nacional de Medicina Genómica; México Fil: González Torres, Carolina. Instituto Nacional de Medicina Genómica; México Fil: Rosas Madrigal, Sandra. Instituto Nacional de Medicina Genómica; México Fil: Ordoñez, Graciela. Neuroimmunología, Instituto Nacional de Neurología y Neurocirugía; México Fil: Guerrero Camacho, Jorge Luis. Instituto Nacional de Neurología y Neurocirugía; México Fil: Treviño Frenk, Irene. American British Cowdray Medical Center; México. Instituto Nacional de la Nutrición Salvador Zubiran; México Fil: Escamilla Tilch, Monica. Instituto Nacional de la Nutrición Salvador Zubiran; México Fil: García Lechuga, Maricela. Instituto Nacional de la Nutrición Salvador Zubiran; México Fil: Tovar Méndez, Víctor Hugo. Instituto Nacional de la Nutrición Salvador Zubiran; México Fil: Pacheco Ubaldo, Hanna. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México Fil: Acuña Alonzo, Victor. Instituto Nacional de Antropología E Historia. Escuela Nacional de Antropología E Historia; México Fil: Bortolini, María Cátira. Universidade Federal do Rio Grande do Sul; Brasil Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú Fil: Bedoya Berrío, Gabriel. Universidad de Antioquia; Colombia Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile Fil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Ruiz Linares, Andrés. Colegio Universitario de Londres; Reino Unido Fil: Canizales Quinteros, Samuel. Universidad Nacional Autónoma de México; México Fil: Yunis, Edmond. Dana Farber Cancer Institute; Estados Unidos Fil: Granados, Julio. Instituto Nacional de la Nutrición Salvador Zubiran; México Fil: Corona, Teresa. Instituto Nacional de Neurología y Neurocirugía; México

Published
2020

6. Genetic contributors to serum uric acid levels in Mexicans and their effect on premature coronary artery disease

Author

Carla Gallo, Paola León-Mimila, Luis Macías-Kauffer, Sofia Moran-Ramos, Andres Ruiz-Linares, Leonor Jacobo-Albavera, Christopher R. Stephens, Victor Acuña-Alonzo, Maria Cátira Bortolini, Francisco J. Flores-Murrieta, Sandra Romero-Hidalgo, Blanca E. Del-Rio-Navarro, Carlos A. Aguilar-Salinas, Teresa Villarreal-Molina, Hugo Villamil-Ramírez, Rolando González-José, Gabriel Bedoya, Carlos Posadas-Romero, Francisco Rothhammer, Rosalinda Posadas-Sánchez, Gilberto Vargas-Alarcón, Cecilia Fernández del Valle-Laisequilla, Samuel Canizales-Quinteros, Blanca E. López-Contreras, Miriam del Carmen Carrasco-Portugal, Rafael Velázquez-Cruz, Lina M. Barranco Garduño, Juan Gerardo Reyes-García, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Dept of Genetics, Evolution and Environment [London] (UCL-GEE), University College of London [London] (UCL), Instituto Nacional de Cardiología, Molecular Genetics Laboratory, Escuela Nacional de Antropologia y Historia, Laboratorio de Genética Molecular, Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Facultad de Medicina & Instituto de Alta Investigacion, Universidad de Tarapaca-Universidade de Chile, Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), Universidad Nacional Autónoma de México (UNAM), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico], and Unit of Molecular Biology and Genomic Medicine

Subjects
Male, obesity, estimated glomerular filtration rate, ABCG2 gene, genotype, [SDV]Life Sciences [q-bio], [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, Genome-wide association study, Coronary Artery Disease, 030204 cardiovascular system & hematology, Bioinformatics, Coronary artery disease, Genética y Herencia, 0302 clinical medicine, single nucleotide polymorphism, genetic variability, gender, purl.org/pe-repo/ocde/ford#3.02.04 [https], 030212 general & internal medicine, Child, ComputingMilieux_MISCELLANEOUS, Aged, 80 and over, child, biology, adult, Mexican, Mendelian Randomization Analysis, Middle Aged, cohort analysis, 3. Good health, aged, female, priority journal, breast cancer resistance protein, Female, Cardiology and Cardiovascular Medicine, CIENCIAS NATURALES Y EXACTAS, uric acid blood level, Adult, gene locus, Adolescent, GENETICS, Mendelian randomization analysis, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Article, Ciencias Biológicas, 03 medical and health sciences, Young Adult, male, Mendelian randomization, medicine, SNP, Humans, controlled study, human, gene, Mexico, Aged, genome-wide association study, business.industry, medicine.disease, major clinical study, Uric Acid, URIC ACID, SLC2A9 gene, biology.protein, CORONARY ARTERY DISEASE, metabolic syndrome X, Metabolic syndrome, business, Biomarkers, SLC2A9, Genome-Wide Association Study
Abstract

Background: Serum uric acid (SUA) is a heritable trait associated with cardiovascular risk factors and coronary artery disease (CAD). Genome wide association studies (GWAS) have identified several genes associated with SUA, mainly in European populations. However, to date there are few GWAS in Latino populations, and the role of SUA-associated single nucleotide polymorphisms (SNPs) in cardiovascular disease has not been studied in the Mexican population. Methods: We performed genome-wide SUA association study in 2153 Mexican children and adults, evaluated whether genetic effects were modified by sex and obesity, and used a Mendelian randomization approach in an independent cohort to study the role of SUA modifying genetic variants in premature CAD. Results: Only two loci were associated with SUA levels: SLC2A9 (β = −0.47 mg/dl, P = 1.57 × 10−42 for lead SNP rs7678287) and ABCG2 (β = 0.23 mg/dl, P = 2.42 × 10−10 for lead SNP rs2231142). No significant interaction between SLC2A9 rs7678287 and ABCG2 rs2231142 genotypes and obesity was observed. However, a significant ABCG2 rs2231142 genotype*sex interaction (P = 0.001) was observed in adults but not in children. Although SUA levels were associated with premature CAD, metabolic syndrome and decreased glomerular filtration rate (eGFR), only ABCG2 rs2231142 was associated with decreased eGFR in the premature CAD group. Conclusions: SUA elevation was independently associated with premature CAD, metabolic syndrome and decreased eGFR in the Mexican population. However, a Mendelian randomization approach using the lead SUA-associated SNPs (SLC2A9 and ABCG2) did not support a causal role of elevated SUA levels for premature CAD. Fil: Macias Kauffer, Luis R.. Instituto Nacional de Medicina Genómica Mexico; México. Universidad Nacional Autónoma de México; México Fil: Villamil Ramírez, Hugo. Instituto Nacional de Medicina Genómica Mexico; México Fil: León Mimila, Paola. Instituto Nacional de Medicina Genómica Mexico; México Fil: Jacobo Albavera, Leonor. Inmegen; México Fil: Posadas Romero, Carlos. Instituto Nacional de Cardiologia Ignacio Chavez; México Fil: Posadas Sánchez, Rosalinda. Instituto Nacional de Cardiologia Ignacio Chavez; México Fil: López Contreras, Blanca E.. Instituto Nacional de Medicina Genómica Mexico; México Fil: Morán Ramos, Sofía. Instituto Nacional de Medicina Genómica Mexico; México Fil: Romero Hidalgo, Sandra. Inmegen; México Fil: Acuña Alonzo, Víctor. Colegio Universitario de Londres; Reino Unido Fil: del Río Navarro, Blanca E.. Hospital Infantil de Mexico Federico Gomez; México Fil: Bortolini, Maria Cátira. Universidade Federal do Rio Grande do Sul; Brasil Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú Fil: Bedoya, Gabriel. Universidad de Antioquia; Colombia Fil: Rothhammer, Francisco. Universidad de Chile; Chile Fil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Ruiz-Linares, Andres. Fudan University; China. Anthropologie Bio-culturelle, Droit, Éthique & Fil: Stephens, Christopher R.. Universidad Nacional Autónoma de México. Instituto de Ciencias Nucleares; México Fil: Velazquez Cruz, Rafael. Instituto Nacional de Medicina Genómica Mexico; México Fil: Fernández del Valle Laisequilla, Cecilia. Productos Medix; México Fil: Reyes-García, Juan G.. INSTITUTO POLITÉCNICO NACIONAL (IPN); Fil: Barranco Garduño, Lina M.. Instituto Nacional de Enfermedades Respiratorias; México Fil: Carrasco-Portugal, Miriam del C.. Instituto Nacional de Enfermedades Respiratorias; México Fil: Flores-Murrieta, Francisco J.. Instituto Nacional de Enfermedades Respiratorias; México. INSTITUTO POLITÉCNICO NACIONAL (IPN); Fil: Vargas Alarcón, Gilberto. Instituto Nacional de Cardiologia Ignacio Chavez; México Fil: Aguilar Salinas, Carlos A.. Escuela de Medicina y Ciencias de la Salud Tecsalud; México. Instituto Nacional de la Nutrición Salvador Zubiran; México Fil: Villarreal Molina, Teresa. Inmegen; México Fil: Canizales Quinteros, Samuel. Instituto Nacional de Medicina Genómica Mexico; México

Published
2019
Full Text
View/download PDF

7. An analysis on Dual Diagnosis Revealed a Possible deviation of Schizophrenia Polygenic Risk Score by Mexican Amerindian Ancestry

Author

Thelma Beatriz González-Castro, Erasmo Saucedo-Uribe, José Jaime Martínez-Magaña, Carlos Alfonso Tovilla-Zárate, Nuria Lanzagorta, Humberto Nicolini, Luis Macías-Kauffer, Alma Delia Genis-Mendoza, Isela Esther Juárez-Rojop, and Michael Escamilla

Subjects
Substance abuse, psychiatry_mental_health_studies, business.industry, Schizophrenia, Medicine, Dual diagnosis, Polygenic risk score, Bipolar disorder, business, medicine.disease, Clinical psychology
Abstract

In order to summarized the polygenic background of psychiatric diseases, polygenic risk scores (PRS) have been developed. Recently, PRS have been use to predict patients with higher comorbidities in psychiatric diseases, like dual diagnosis. PRS are principally derived in analysis of Caucasian and Asian populations, we are not aware of how this PRS could be applied in populations with high admixture. In order to explored this, the present work has the aim to analyzed if previous calculated PRS for psychiatric diseases could predict dual diagnosis in Mexican population, and also, if PRS calculation could be influenced by Mexican Amerindian (MA) global ancestry. We performed PRS calculation, using PRSice, with summary genome-wide association statistics previously published for psychiatric diseases, and also, performed Nagelkerke correlation test in order to established if PRS are correlated with dual diagnosis. We found that dual diagnosis could be predicted by major depressive disorder polygenic risk score. Nevertheless, schizophrenia polygenic risk score is highly correlated with global MA ancestry, independently of the schizophrenia diagnosis. Our results reinforced the notion that PRS calculation could be deviated by the MA global ancestry, nevertheless analysis on larger sample sizes are required in order to clarified this issue.

Published
2018

8. A higher bacterial inward BCAA transport driven by Faecalibacterium prausnitzii is associated with lower serum levels of BCAA in early adolescents

Author

Sofia Moran-Ramos, Luis Macias-Kauffer, Blanca E. López-Contreras, Hugo Villamil-Ramírez, Elvira Ocampo-Medina, Paola León-Mimila, Blanca E. del Rio-Navarro, Omar Granados-Portillo, Isabel Ibarra-Gonzalez, Marcela Vela-Amieva, Armando R. Tovar, Nimbe Torres, Francisco J. Gomez-Perez, Carlos Aguilar-Salinas, and Samuel Canizales-Quinteros

Subjects
BCAA, Gut microbiome, Children, Faecalibacterium prausnitzii, Insulin resistance, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436
Abstract

Abstract Background Elevations of circulating branched-chain amino acids (BCAA) are observed in humans with obesity and metabolic comorbidities, such as insulin resistance. Although it has been described that microbial metabolism contributes to the circulating pool of these amino acids, studies are still scarce, particularly in pediatric populations. Thus, we aimed to explore whether in early adolescents, gut microbiome was associated to circulating BCAA and in this way to insulin resistance. Methods Shotgun sequencing was performed in DNA from fecal samples of 23 early adolescents (10–12 years old) and amino acid targeted metabolomics analysis was performed by LC–MS/MS in serum samples. By using the HUMAnN2 algorithm we explored microbiome functional profiles to identify whether bacterial metabolism contributed to serum BCAA levels and insulin resistance markers. Results We identified that abundance of genes encoding bacterial BCAA inward transporters were negatively correlated with circulating BCAA and HOMA-IR (P

Published
2021
Full Text
View/download PDF

9. Depression polygenic scores are associated with major depressive disorder diagnosis and depressive episode in Mexican adolescents

Author

Jill A. Rabinowitz, Adrian I. Campos, Corina Benjet, Jinni Su, Luis Macias-Kauffer, Enrique Méndez, Gabriela A. Martinez-Levy, Carlos S. Cruz-Fuentes, and Miguel E. Rentería

Subjects
Depression, Polygenic risk scores, Genetics, Adversity, Mexican, Adolescence, Mental healing, RZ400-408
Abstract

Objective: Large-scale genome-wide association studies have uncovered genetic variants associated with depression; however, most of this work has been limited to adults of European ancestry. We investigated the ability of depression polygenic risk scores (PRS) to predict both lifetime and past year major depressive disorder (MDD) diagnosis and major depressive episode (MDE) in a sample of adolescents with admixed ancestry from Mexico City, and explored whether adverse life events moderated these relations. Methods: The study sample consisted of adolescents aged 12–17 (N = 1,123) who were interviewed and genotyped as part of a general population survey on adolescent mental health. PRS for depression were derived using summary statistics from a large-scale discovery genome-wide association study conducted on depressive symptoms that included over 800,000 individuals of European ancestry (Howard et al., 2019). Results: Higher depression PRS were associated with a greater likelihood of both past year MDD and MDE and lifetime MDE, accounting for 1.5–2.5% of the variance in these outcomes. Adversity did not moderate the relationship between depression PRS and lifetime or past year MDD or MDE. Limitations: This study is cross-sectional. As such, some participants might have experienced MDD/MDE after the interview. In addition, our sample comprised only Mexican youth and thus, findings may not generalize to other populations. Conclusions: Our results indicate that depression PRS derived from a European ancestry GWAS are associated with MDD and MDE risk among Mexican adolescents and have the potential to aid in the identification of youth who may be genetically prone to depression.

Published
2020
Full Text
View/download PDF

10. A Longitudinal 1H NMR-Based Metabolic Profile Analysis of Urine from Hospitalized Premature Newborns Receiving Enteral and Parenteral Nutrition

Author

Nuria Esturau-Escofet, Eduardo Rodríguez de San Miguel, Marcela Vela-Amieva, Martha E. García-Aguilera, Circe C. Hernández-Espino, Luis Macias-Kauffer, Carlos López-Candiani, José J. Naveja, and Isabel Ibarra-González

Subjects
prematurity, enteral feeding, parenteral nutrition, 1H NMR-based metabolic profile, chemometric analysis, Microbiology, QR1-502
Abstract

Preterm newborns are extremely vulnerable to morbidities, complications, and death. Preterm birth is a global public health problem due to its socioeconomic burden. Nurturing preterm newborns is a critical medical issue because they have limited nutrient stores and it is difficult to establish enteral feeding, which leads to inadequate growth frequently associated with poor neurodevelopmental outcomes. Parenteral nutrition (PN) provides nutrients to preterm newborns, but its biochemical effects are not completely known. To study the effect of PN treatment on preterm newborns, an untargeted metabolomic 1H nuclear magnetic resonance (NMR) assay was performed on 107 urine samples from 34 hospitalized patients. Multivariate data (Principal Component Analysis, PCA, Orthogonal partial least squares discriminant analysis OPLS-DA, parallel factor analysis PARAFAC-2) and univariate analyses were used to identify the association of specific spectral data with different nutritional types (NTs) and gestational ages. Our results revealed changes in the metabolic profile related to the NT, with the tricarboxylic acid cycle and galactose metabolic pathways being the most impacted pathways. Low citrate and succinate levels, despite higher glucose relative urinary concentrations, seem to constitute the metabolic profile found in the studied critically ill preterm newborns who received PN, indicating an energetic dysfunction that must be taken into account for better nutritional management.

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results