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7 results on '"Losada, Begoña"'

2. Effectiveness and Safety of Direct-acting Antivirals for Treatment of Adolescents With HCV/HIV Coinfection: Real-world Data From Europe

Author

Malik, Farihah, Crichton, Siobhan, Plotnikova, Yulia, Latysheva, Inga, Samarina, Anna, Pokorska-Śpiewak, Maria, Gomez, Marisa Navarro, Bailey, Heather, Thorne, Claire, Judd, Ali, Turkova, Anna, Collins, Intira Jeannie, Marczyńska, Magdalena, Popielska, Jolanta, Ołdakowska, Agnieszka, Zawadka, Konrad, Pluta, Magdalena, Doroba, Małgorzata, Okhonskaya, Liubov, Rozenberg, Vladimir, Voronin, Evgeny, Plynsky, Alexksey A., José Mellado, María, Escosa, Luis, García Hortelano, Milagros, Sainz, Talía, Grasa, Carlos, Rodríguez, Paula, Rojo, Pablo, Prieto-Tato, Luis, Epalza, Cristina, Tagarro, Alfredo, Domínguez, Sara, Ballesteros, Álvaro, Tomás Ramos, José, Illán, Marta, Berzosa, Arantxa, Guillén, Sara, Soto, Beatriz, Luisa Navarro, María, Saavedra, Jesús, Santos, Mar, Aguilera, David, Santiago, Begoña, Jimenez de Ory, Santiago, Bermejo, Amanda, Penín, María, Martínez, Jorge, Badillo, Katie, Belén Jiménez, Ana, Navas, Adriana, Oñate, Eider, Pocheville, Itziar, Garrote, Elisa, Colino, Elena, Afonso, Olga, Gómez Sirvent, Jorge, Garzón, Mónica, Román, Vicente, Angulo, Raquel, Neth, Olaf, Falcón, Lola, Terol, Pedro, Luis Santos, Juan, Vázquez, Álvaro, Carazo, Begoña, Medina, Antonio, Lendínez, Francisco, Ibáñez, Mercedes, Peromingo, Estrella, Isabel Sánchez, María, Ruiz, Beatriz, Grande, Ana, José Romero, Francisco, Pérez, Carlos, Calle, Laura, Pareja, Marta, Losada, Begoña, Herranz, Mercedes, Bustillo, Matilde, Collado, Pilar, Antonio Couceiro, José, Vila, Leticia, Calviño, Consuelo, Isabel Piqueras, Ana, Oltra, Manuel, Gavilán, César, Montesinos, Elena, Dapena, Marta, Jiménez, Beatriz, Gloria Andrés, Ana, Marugán, Víctor, Ochoa, Carlos, Isabel Menasalvas, Ana, Cervantes, Eloísa, Álvarez, Beatriz, Díez, Cristina, Bernardino, Ignacio, Luisa Montes, María, Valencia, Eulalia, Delgado, Ana, Rubio, Rafael, Pulido, Federico, Bisbal, Otilia, Monereo Alonso, Alfonso, Berenguer, Juan, Díez, Cristina, Aldamiz, Teresa, Tejerina, Francisco, Carlos Bernaldo de Quirós, Juan, Padilla, Belén, Carrillo, Raquel, Montilla, Pedro, Bermúdez, Elena, Valerio, Maricela, Sanz, Jose, Gimeno, Alejandra, Cervero, Miguel, Torres, Rafael, Moreno, Santiago, Jesús Perez, María, del Campo, Santos, Ryan, Pablo, Troya, Jesus, Sanz, Jesus, Losa, Juan, Gomez, Rafael, Górgolas, Miguel, Díaz, Alberto, de la Fuente, Sara, Antonio Iribarren, Jose, Jose Aramburu, Maria, Martinez, Lourdes, Josune Goikoetxea, Ane, Ibarra, Sofia, de la Peña, Mireia, Asensi, Víctor, Hernandez, Michele, Remedios Alemán, María, Pelazas, Ricardo, del Mar Alonso, María, María López, Ana, García, Dácil, Rodriguez, Jehovana, Angel Cardenes, Miguel, Castaño, Manuel A., Orihuela, Francisco, Pérez, Inés, Isabel Mayorga, Mª, Fernando Lopez-Cortes, Luis, Roca, Cristina, Llaves, Silvia, Jose Rios, Maria, Rodriguez, Jesus, Palomo, Virginia, Pasquau, Juan, Garcia, Coral, Hernandez, Jose, Martinez, Clara, Rivero, Antonio, Camacho, Angela, Merino, Dolores, Raffo, Miguel, Corpa, Laura, Martinez, Elisa, Mateos, Fernando, Javier Blanch, Jose, Torralba, Miguel, Arazo, Piedad, Samperiz, Gloria, Miralles, Celia, Ocampo, Antonio, Pousada, Guille, Mena, Alvaro, Montero, Marta, Salavert, Miguel, Jose Galindo, Maria, Pretel, Natalia, Portilla, Joaquín, Portilla, Irene, Gutierrez, Felix, Masia, Mar, Robledano, Cati, Adsuar, Araceli, Hinojosa, Carmen, Monteagudo, Begoña, Bachiller, Pablo, Abadía, Jesica, Galera, Carlos, Albendin, Helena, Fernandez, Marian, and Ramon Blanco, Jose

Published
2024
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3. Young adults and HIV. Awareness and risk behaviour of a group living in Spain

Author

Velo-Higueras, Carlos, Cuéllar-Flores, Isabel, Sainz-Costa, Talía, Navarro-Gómez, M. Luisa, García-Navarro, Cristina, Fernández-McPhee, Carolina, Ramírez, Alejandro, Bisbal, Otilia, Blazquez-Gamero, Daniel, Ramos-Amador, José Tomás, Valencia-Ortega, Eulalia, González-Tomé, M. Isabel, Mellado, María José, Escosa, Luis, Hortelano, Milagros García, Sainz, Talía, González-Tomé, María Isabel, Rojo, Pablo, Blázquez, Daniel, Fernández, Elisa, Epalza, Cristina, Zamora, Berta, Martin, Manuela, Velo, Carlos, de Aragón, Ana Martínez, Ramos, José Tomás, Cuellar, Isabel, Prieto, Luis, Guillén, Sara, Navarro, María Luisa, Saavedra, Jesús, Santos, Mar, Muñoz, M. Ángeles, Ruiz, Beatriz, McPhee, Carolina Fernández, de Ory, Santiago Jiménez, Álvarez, Susana, Fortuny, Claudia, Noguera, Ton, Moreno, David, Núñez, Esmeralda, Neth, Olaf, Falcón, Dolores, Roa, Miguel Ángel, Beceiro, José, Martínez, Jorge, Badillo, Katie, Apilanez, Miren, Pocheville, Itziar, Garrote, Elisa, Colino, Elena, Sirvent, Jorge Gómez, Garzón, Mónica, Román, Vicente, Montesdeoca, Abián, Mateo, Mercedes, Muñoz, María José, Angulo, Raquel, Falcón, Lola, Terol, Pedro, Santos, Juan Luis, Lendínez, Francisco, Grande, Ana, Romero, Francisco José, Pérez, Carlos, Lillo, Miguel, Losada, Begoña, Herranz, Mercedes, Bustillo, Matilde, Guerrero, Carmelo, Collado, Pilar, Couceiro, José Antonio, Pérez, Amparo, Piqueras, Ana Isabel, Bretón, Rafael, Segarra, Inmaculada, Gavilán, César, Jareño, Enrique, Montesinos, Elena, Dapena, Marta, Álvarez, Cristina, Andrés, Ana Gloria, Marugán, Víctor, Ochoa, Carlos, Alfayate, Santiago, Menasalvas, Ana Isabel, and de Miguel, Elisa

Published
2019
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5. Efficient Building of Interactive Applications Guided by Requirements Models.

Author

Losada, Begoña, Urretavizcaya, Maite, and Fernández de Castro, Isabel

Abstract

The analysis of functional and non-functional requirements of an interactive application not only encompasses the descriptive aspects of its functionality and the user and system restrictions, it must also satisfy user needs, such as usability, along with system needs, such as reliability. InterMod is an interactive application-design methodology with agile characteristics which proposes the use of incremental models to define requirements, configure presentation and develop functionality. This poster is focused on the requirements of the InterMod methodology for the efficient construction of interactive applications. These models include user, system, task and dialog models. An example created with a tool that follows these principles and illustrates our approach to the dialog model is presented. [ABSTRACT FROM AUTHOR]

Published
2009
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6. A guide to agile development of interactive software with a “User Objectives”-driven methodology.

Author

Losada, Begoña, Urretavizcaya, Maite, and Fernández-Castro, Isabel

Subjects
*AGILE software development, *COMPUTER software, *COMPUTER users, *USER-centered system design, *USER interfaces, *PROTOTYPES
Abstract

Abstract: This paper presents the InterMod methodology. By combining the widely accepted Agile Methods, Model-Driven Developments and User-Centred Design it allows us to develop high-quality interactive applications. As a main characteristic, it plans and organises the software project as a series of iterations that are guided by the User Objectives in an agile and user-centred manner. At each iteration, the software development work can be distributed to different teams according to some developmental and integration activities. Each activity is driven by models that are validated by a multidisciplinary team composed of developers and users. The requirements are incrementally collected and formalised by means of models based on user-centred design. Besides, the Semantically Enriched Human–Computer Interaction model is proposed to speed up project validation. This model enriches a human–computer interaction model with some visual characteristics and the application semantic. Thus, the enriched model provides enough information to generate prototypes so users and developers can easily validate this model. Diagram project is a real case study that is used to illustrate the application of the InterMod methodology through the whole paper. [Copyright &y& Elsevier]

Published
2013
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7. Postnatal maturation of phosphodiesterase 5 (PDE5) in piglet pulmonary arteries: activity, expression, effects of PDE5 inhibitors, and role of the nitric oxide/cyclic GMP pathway.

Author

Moreno L, Losada B, Cogolludo Al, Lodi F, Lugnier C, Villamor E, Moro M, Tamargo J, and Pérez-Vizcaíno F

Subjects
3',5'-Cyclic-GMP Phosphodiesterases antagonists & inhibitors, Animals, Animals, Newborn, Blotting, Western, Cyclic Nucleotide Phosphodiesterases, Type 5, Dipyridamole pharmacology, In Vitro Techniques, Male, Nitroprusside pharmacology, Phosphodiesterase Inhibitors pharmacology, Piperazines pharmacology, Purines, Purinones pharmacology, Sildenafil Citrate, Sulfones, Swine, Vasodilation drug effects, Vasodilator Agents pharmacology, 3',5'-Cyclic-GMP Phosphodiesterases metabolism, Cyclic GMP metabolism, Nitric Oxide metabolism, Pulmonary Artery enzymology, Pulmonary Artery growth & development
Abstract

After birth and during the first days of extrauterine life, pulmonary arterial pressure is progressively reduced to reach the adult values. We hypothesized that changes in PDE5 activity might be involved in the pulmonary postnatal maturation of the nitric oxide (NO)/cGMP pathway. The PDE5 inhibitor sildenafil produced vasorelaxant responses in isolated pulmonary arteries. These effects were similar in newborn (3-18 h) and 2-wk-old piglets, unchanged by endothelium removal, and markedly inhibited by the soluble guanylyl cyclase inhibitor ODQ. The peak of the transient vasorelaxant response to NO gas increased with postnatal age but was unaffected by PDE inhibition. However, the duration of the response to NO was significantly increased. The vasorelaxant response to sodium nitroprusside was potentiated by sildenafil in both age groups. The PDE5 inhibitors dipyridamole and zaprinast, produced qualitatively similar effects but with lower potency. Both total and PDE5-dependent cGMP hydrolytic activity and PDE5 protein expression increased with postnatal age. All these results suggest that PDE5 is a key regulator of NO-induced vasodilation in the postnatal pulmonary arteries. PDE5 inhibition is able to produce pulmonary vasodilation even in the absence of a functional endothelium and potentiates the vasorelaxant response to exogenous NO and nitroprusside. However, PDE5 is not responsible for the maturational increase of NO bioactivity during the first days of extrauterine life.

Published
2004
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