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In this paper, the contents of 12 mineral elements in 100 samples of four types of takeaway fast food, including porridge and noodles, special snacks, Chinese fast food and Western fast food, sold in Beijing were analyzed by ICP-MS, and the RNI and UL values of the elements were used as the assessment criteria for preliminary dietary nutritional assessment of different age groups. The results showed that the range of mineral element contents in the samples was wide and the degree of dispersion was large. The intakes of Na, I and Cr could meet the daily dietary needs of the whole population in all types of takeaway samples, while the intakes of Ca, Mg and Fe were insufficient. The insufficient intakes of K, Zn, Cu, Mn, Mo and Se were found in some of the samples of some populations. The intakes of the 12 elements showed different degrees of variability among the four types of takeaways, with lower intakes of each element in congee and noodle dishes, and K, Ca, Mg, Zn, Fe, Se and Cr showed significant differences from the other three types. The intake of each element was lower in congee and noodles, which showed significant differences with the other three categories. In addition, the intake of take-away fast food was found to be excessive, with Zn and I exceeding 1.1%~5.3% and 3.6%~14.3%, respectively, in different age groups. The results showed that the long-term take-away population should pay attention to adjusting their dietary structure, balancing the intake of take-away food containing meat, vegetables, legumes, eggs and milk, and appropriately replenishing various types of minerals with insufficient intake. At the same time the health risks of “over-nutrition” brought about by fast food takeaways should be paid attention, and the young minors were the key concern groups.

For various engineering applications in public, ceramics with exceptional strength, toughness and shock resistance are imminently required, but traditional ceramics struggle to meet these demands due to their fragility. Inspired by the shape of natural conch shells, this work offers a simple hot press approach to fabricate layered porcelain ceramic tile/Kevlar fabric composites, yielding excellent mechanical properties and the capacity for non-catastrophic failure. It was concluded that composites’ excellent mechanical performance is attributed to the resin/fabric content. The composite with the resin/fabric content of 45.5 vol.% had an outstanding combination of high strength (310.5 ± 6.2MPa) and excellent fracture toughness (6.83 ± 0.09MPa•m1/2), whereas the sample with 36.4 vol.% resin/fabric content had the maximal impact energy of 2.04 ± 0.09 J, which is much better than those of traditional ceramics. The strong resistance to fracture is a result of the proper interfacial bonding and the presence of elastic component, which enables toughening mechanisms such as crack deflection, fibre pull-out and interfacial debonding. This finding provides useful guidance for replacing lowperformance ceramics in engineering applications with cost-effective ceramic composites.

For a long-term complex Action, it is typically composed of various short-term Actions. The speed and importance of these short-term Actions directly affect the recognition results. Current two-stream neural networks have already achieved good recognition results on Action recognition datasets. However, previous two-stream networks have focused more on Action modeling, neglecting the impact of the speed and importance of different short-term Actions on the results of Action recognition. This has directly limited the model’s ability to model different short-term Actions, thereby affecting the effectiveness of Action recognition. To address this issue, this paper proposes a Short-term Action Spatio-Temporal Attention (STASTA) module based on the two-stream network structure. The STASTA module is capable of focusing on the differences in importance and speed between different short-term Actions. By extracting the differences in importance and speed of different short-term Actions in the video and then fusing the features, the aim is to enrich spatio-temporal features and improve Action recognition performance. The proposed method is evaluated on the Something-Something v1 & v2 and Charades datasets. A large number of experimental results indicate that the method proposed in this paper achieves state-of-the-arts results among video Action recognition methods.

[Objective]To addresses the problem of traversing multiple fields for agricultural robots in hilly terrain, a traversal path planning method is proposed by combining the Floyd algorithm with an improved genetic algorithm. The method provides a solution that can reduce the cost of agricultural robot operation and optimize the order of field traversal in order to improve the efficiency of farmland operation in hilly areas and realizes to predict how an agricultural robot can transition to the next field after completing its coverage path in the current field.[Methods]In the context of hilly terrain characterized by small and densely distributed field blocks, often separated by field ridges, where there was no clear connectivity between the blocks, a method to establish connectivity between the fields was proposed in the research. This method involved projecting from the corner node of the headland path in the current field to each segment of the headland path in adjacent fields vertically. The shortest projected segment was selected as the candidate connectivity path between the two fields, thus establishing potential connectivity between them. Subsequently, the connectivity was verified, and redundant segments or nodes were removed to further simplify the road network. This method allowed for a more accurate assessment of the actual distances between field blocks, thereby providing a more precise and feasible distance cost between field blocks for multi-block traversal sequence planning. Next, the classical graph algorithm, Floyd algorithm, was employed to address the shortest path problem for all pairs of nodes among the fields. The resulting shortest path matrix among headland path nodes within fields, obtained through the Floyd algorithm, allowed to determine the shortest paths and distances between any two endpoint nodes in different fields. This information was used to ascertain the actual distance cost required for agricultural machinery to transfer between fields. Furthermore, for the genetic algorithm in path planning, there were problems such as difficult parameter setting, slow convergence speed and easy to fall into the local optimal solution. This study improved the traditional genetic algorithm by implementing an adaptive strategy. The improved genetic algorithm in this study dynamically adjusted the crossover and mutation probabilities in each generation based on the fitness of the previous generation, adapting to the problem's characteristics. Simultaneously, it dynamically modified the ratio of parent preservation to offspring generation in the current generation, enhancing population diversity and improving global solution search capabilities. Finally, this study employed genetic algorithms and optimization techniques to address the field traversal order problem, akin to the Traveling Salesman Problem (TSP), with the aim of optimizing the traversal path for agricultural robots. The shortest transfer distances between field blocks obtained through the Floyd algorithm were incorporated as variables into the genetic algorithm for optimization. This process leads to the determination of an optimized sequence for traversing the field blocks and the distribution of entry and exit points for each field block.[Results and Discussions]A traversal path planning simulation experiment was conducted to compare the improved genetic algorithm with the traditional genetic algorithm. After 20 simulation experiments, the average traversal path length and the average convergence iteration count of the two algorithms were compared. The simulation results showed that, compared to the traditional genetic algorithm, the proposed improved genetic algorithm in this study shortened the average shortest path by 13.8%, with fewer iterations for convergence, and demonstrated better capability to escape local optimal solutions. To validate the effectiveness of the multi-field path planning method proposed in this study for agricultural machinery coverage, simulations were conducted using real agricultural field data and field operation parameters. The actual operating area located at coordinates (103.61°E, 30.47°N) was selected as the simulation subject. The operating area consisted of 10 sets of field blocks, with agricultural machinery operating parameters set at a minimum turning radius of 1.5 and a working width of 2. The experimental results showed that in terms of path length and path repetition rate, the present method showed more superior performance, and the field traversal order and the arrangement of imports and exports could effectively reduce the path length and path repetition rate.[Conclusions]The experimental results proved the superiority and feasibility of this study on the traversing path planning of agricultural machines in multiple fields, and the output trajectory coordinates of the algorithm can serve as a reference for both human operators and unmanned agricultural machinery during large-scale operations. In future research, particular attention will be given to addressing practical implementation challenges of intelligent algorithms, especially those related to the real-time aspects of navigation systems and challenges such as Kalman linear filtering. These efforts aim to enhance the applicability of the research findings in real-world scenarios.

With the transformation of the new medical structure in the new era, the center of gravity of treatment for patients with mental disorders gradually shifted from the hospital to the community. The study randomly divided 70 community hospitalized patients with mental disorders who met the diagnostic criteria into an experimental group and a control group of 35 patients each and treated them with visualization music therapy and traditional spiritual rehabilitation therapy, respectively. At the end of the treatment, the basic characteristics, sleep quality, cognitive function, and related symptoms of the patients with community psychiatric disorders before and after the treatment were analyzed by using independent samples t-test, and the quality of life and intimate adaptability of the patients after community rehabilitation before and after the treatment were also explored. The results showed that there were significant time main effects in depression (F=234.801, P

BackgroundGinseng Radix et Rhizoma (GS) is frequently used as an adjuvant therapy for patients with heart failure (HF). Metoprolol is widely used in patients with HF. However, there is no report on the combined effects of GS and metoprolol in patients with HF.ObjectiveThis study investigated the combined effects of GS and metoprolol in male C57BL/6J mice with HF and the underlying mechanisms.Materials and methodsWe utilized a mouse myocardial HF model to measure the serum levels of creatine kinase (CK) and creatine kinase-MB form (CK-MB) using an automated biochemical analyzer. Lactate dehydrogenase (LDH) and cardiac troponin (cTnT) levels were determined using enzyme-linked immunosorbent assays. Autophagy of myocardial cells was evaluated using transmission electron microscopy, and changes in signal pathway proteins related to autophagy were analyzed by Western blotting.ResultsGS combined with metoprolol improved heart function, reduced heart damage, and decreased serum levels of CK, CK-MB, LDH, and cTnT. The combination of GS and metoprolol decreased autophagy in myocardial cells by reducing the levels of autophagy-related proteins (LC3, p62, Beclin1, and Atg5) and increasing the ratios of p-PI3K/PI3K, p-Akt/Akt, and p-mTOR/mTOR.ConclusionGS enhanced the anti-heart failure effect of metoprolol. Its mechanism of action might be related to the inhibition of autophagy mediated by the activation of the PI3K/Akt/mTOR pathway.

The catenary system, as a framework within railway electrification projects, constitutes an exposed suspension structure deployed along railway lines. It serves the purpose of providing electrical power to electric locomotives through pantographs but lacks backup facilities and falls into the category of a specialized form of high-voltage transmission line. To ensure the safety and reliability of the catenary system and the stable current collection of the pantograph, thereby safeguarding railway operational safety, it is imperative to research the aerodynamic response of the catenary system induced by environmental winds. For this study, the catenary system in the 4m windbreak wall section of the Lanzhou-Xinjiang high-speed railway bridge has been selected as the research subject. To determine wind speed correction coefficients at the supporting cable and contact wire locations, a finite element model was created using wind tunnel experiments and numerical simulations. Samples of wind speed fluctuation have been obtained using the harmonic synthesis method. Based on quasi-steady aerodynamic theory, a temporal analysis has been conducted on the aerodynamic response of supporting cables and contact wires under the influence of both average and fluctuating winds. Temporal results, such as lift at positive and negative positioning locations and mid-span displacement, have been extracted to assess whether the existing structure complies with regulatory requirements. This study offers valuable insights for engineering applications that are similar.

With the continuous development of information technology, digitalization and networking have become the main features of today’s society; in such a context, ideological and political education in higher education institutions faces many challenges. In this paper, the acceptance process of ideological and political education for higher vocational students is divided into five major elements: transmission subject, acceptance subject, acceptance object, acceptance intermediary, and acceptance environment, and the interaction mechanism between the five major elements is analyzed. Secondly, it proposes to adopt the knowledge tracking of fusion learning factors (EKPT) model to decompose contradictory factors for the prior probability of curriculum fusion ideological and political knowledge matrix V and the prior probability of fusion ideological and political elements modeling students’ knowledge level tensor U. The final results of the empirical analysis of acceptance of ideological and political education based on the EKPT model show that the correlation coefficients between teaching efficacy and acceptance of ideological and political teaching behaviors range from 0.361-0.559, and the correlation coefficients between psychological strength, psychological optimism, total psychological resilience scores, and ideological and political teaching efficacy show high correlations ranging from 0.538-0.683. The research in this paper helps higher education institution’s ideological and political education to better adapt to the needs of the data era and improve students’ ideological and political quality and comprehensive literacy.

In order to improve the processing quality of wheat, newly harvested wheat was treated with glow discharge cold plasma. The changes in the physicochemical properties of wheat flour and the rheological properties of wheat flour dough after the treatment were studied, and the molecular mass distribution and secondary structure of wheat flour proteins were furthermore analyzed. The results showed that the gluten index of wheat was significantly increased after cold plasma treatment with oxygen or argon as the gas source. Dough development time and stability time were improved, and the mixographic parameters midline integral at 8 min (MTxI) and midline width at 8 min (MTxW) were significantly increased (P < 0.05), while weakening slope (WS) was significantly decreased (P < 0.05). The content of macromolecular polymeric storage protein fraction F1 was increased, and the ratio between macromolecular polymeric storage protein fraction F1 and small-molecule polymeric storage protein fraction F2 was significantly increased (P < 0.05). The protein secondary structure was transformed from β-sheet and β-turn to more ordered intermolecular β-sheet. In conclusion, glow discharge cold plasma treatment changed the molecular mass distribution and secondary structure of wheat storage proteins, significantly enhanced the elasticity and mixing tolerance of dough, and improved the tensile resistance of dough, thereby enhancing the processing quality of wheat to some extent.

Objective: To develop pigmented rice lactic acid beverage with good antioxidant and hypoglycemic activity. Methods: Taking black and purple rice as the main material, the effect of mass ratio of purple rice to black rice, the addition amount of Lactobacillus bacteria, fermentation time and solid-liquid ratio on the sensory evaluation value, total phenolics content, ferric ion reducing antioxidant power （FRAP）, ABTS free radical scavenging ability, and the inhibition rate of α-glucosidase of pigmented rice lactic acid beverage were explored. Results: The optimal technology of pigmented rice lactic acid beverage was as follows: the mass ratio of purple rice to black rice was 1∶5, the solid-liquid ratio was 1∶8 （g/mL）, the addition amount of lactic acid bacteria was 5%, and the fermentation time was 40 h. Under these conditions, the sensory score of pigmented rice lactic acid beverage was 83.6±2.51, ABTS radical scavenging capacity was （145.02±7.88） mmol TE/g·DW, FRAP was （33.41±1.70） mmol Fe2+/g·DW, total phenolics were （4 208.78±281.26） μg GAE/g·DW, α-glucosidase inhibitory rate activity was （13.94±0.01）%. Conclusion: The pigmented rice lactic acid beverage possessed purplish red color, soft in taste, moderate in sour and sweet taste, with good antioxidant activity and α-glucosidase inhibition effect.

Maturity-onset diabetes of the young type 3 (MODY3) is a specific type of diabetes mellitus with inherited impairment of the islet β cell function due to the mutation in the hepatocyte nuclear factor 1α (HNF1α) gene. It is a rare condition and easily misdiagnosed as T1DM or T2DM. In this study, the clinical features of two unrelated Chinese MODY3 probands were described and analyzed. Next-generation sequencing was performed to identify the mutated genes, and Sanger sequencing was employed to verify the location of the pathogenic variant in the related family members. It was found that proband 1 inherited a start codon mutation c.2T>C (p.Met1?) in exon 1 of the HNF1α gene from his affected mother, and proband 2 inherited a frameshift mutation c.1136_1137del (p.Pro379fs) in exon 6 of the HNF1α gene also from her affected mother. Proband 1 and proband 2 differed in islet dysfunction, complications, and treatments due to their different disease durations and levels of hemoglobin A1c (HbA1c). The findings of this study demonstrate that early identification of MODY and diagnosis through genetic testing are critical for the treatment of the patient.

NK cells-based cancer therapy combined with chemotherapeutic drugs for the treatment of tumors can enhance the immunosensitivity of NK cells, increase the expression of NK cell receptors, and eventually boost the killing effect of NK cells on cancer cells. Selenium (Se) with different chemical structures can be metabolized into selenoproteins to regulate tumor and immune cells’ fate and functions. Herein, we found that, functionalized Se nanoparticles (SeNPs) combining with metformin (met) could amply the immunotherapeutic effects of NK92 cells against osteosarcoma cancer. The results revealed that TW80-SeNPs combined with met had the optimum performance on NK92 cells for HepG2 cells, owing to the increased ROS in HepG2 cells and the augmented expression of cell surface receptor proteins ULBP-3/4, PD-L1, MICA, and NK92 cell surface receptor proteins PD-1 and FasL. Additionally, TW80-SeNPs were gradually metabolized into selenoproteins (Gpx4 and TR1) into human osteosarcoma MG63 cells to reinforce the anticancer effect of NK92 cells by regulating the redox balance in the tumor microenvironment. This study provides a therapeutic approach in treating cancer itself or diabetes coupled with cancer. Moreover, it provides a multidrug strategy to improve immune cell function in practical applications, especially for synergistic immunotherapy of osteosarcoma.

The Fuchuan peridotites have dual features of mid-ocean ridge basalt and supra-subducted zone peridotites and have been experienced high degrees of partial melting; chondrite-normalized “U”-shaped rare earth element (REE) patterns of Fuchuan harzburgites indicate that light REE enriched SSZ melts or fluids have participated in the interaction with peridotites; the Fuchuan chromitites are enriched in IPGE and depleted in PPGE, which are basically consistent with high-Al chromitites worldwide, and the low PGE concentrations of chromitites reflect a lack of sulfur saturation of the parental melts during an early stage of their crystallization; the Fuchuan peridotites and chromitites are believed to be formed in a back-arc spreading ridge between the Yangtze and Cathaysia blocks during 860–820 Ma.

Carbon dioxide emission is a high-profile issue that can affect both the human economy and human existence, but few scholars have studied the relationship between these two. Therefore, this study constructs the panel threshold regression (PTR) based on the National Bureau of Statistics of China's panel data from 2002 to 2019 in 19 regions. One of the advantages of PTR is to leverage segmented functions, allowing for a more detailed analysis of the data. Besides, by introducing the idea of a threshold, PTR can effectively avoid structural changes in the data. The different between this study and other research is that this study divides 19 regions into two parts: Eastern China and Central China. Based on that, this study researches and compares the different influences of the aging population on carbon emissions in these two regions. The results show that although the Environment Kuznets Curve has been confirmed in both Eastern China and Central China, with the development of the economy, the carbon emissions will increase in Eastern China and decrease in Central China, respectively. In addition, the key factors affecting carbon emissions in Eastern China and Central China are trade dependence and urbanization rate separately. Hence, this study suggests that the regional governments in Eastern China may guide and encourage more international trading companies to move to Central China, and at the same time, the regional governments in Central China should issue more policies to attract these companies, such as: reducing land lease fees and building better transportation infrastructure. Apart from that, the governments in Central China should vigorously increase the rate of urbanization to reduce energy consumption and improve energy efficiency.

Mitophagy affects the activation of hepatic stellate cells (HSCs). Mitochondria-targeted ubiquinone (MitoQ) is a mitochondria-targeted antioxidant that reduces the production of intracellular reactive oxygen species (ROS). However, its relationship with mitophagy remains unclear. This study evaluated mitophagy during HSC activation and the effects of MitoQ on mitophagy in cell culture and in an animal model of the activation of HSCs. We found that MitoQ reduced the activation of HSCs and alleviated hepatic fibrosis. PINK1 (PTEN-induced putative kinase 1) is a putative serine/threonine kinase located in the mitochondria’s outer membrane. While the activation of primary HSCs or LX-2 cells was associated with reduced PINK1/parkin-mediated mitophagy, MitoQ reduced intracellular ROS levels, enhanced PINK1/parkin-mediated mitophagy, and inhibited the activation of HSCs. After knocking down the key mitophagy-related protein, PINK1, in LX-2 cells to block mitophagy, MitoQ intervention failed to inhibit HSC activation. Our results showed that MitoQ inhibited the activation of HSCs and alleviated hepatic fibrosis by enhancing PINK1/parkin-mediated mitophagy.

Objective To investigate the correlation of olfactory function and cognitive function and motor symptoms in patients with primary Parkinson's disease (PD). Methods Total 152 patients with PD diagnosed and treated were recruited from August 2018 to October 2019 in The First Affiliated Hospital of Anhui Medical University. The Chinese Smell Indentification Test (CSIT) was used to evaluate the olfactory recognition function. According to the test results, patients were divided into the normal olfactory group (n=62) and the olfactory disorder group (n=90). The Unified Parkinson's Disease Assessment Scale Ⅲ (UPDRS Ⅲ) was used to evaluate the motor function, the Montreal Cognitive Assessment Scale (MoCA) Beijing edition was used to evaluate the degree of cognitive function, the Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Rating Scale (HAMA) were used to assess the patients' depression and anxiety levels. Patients' visual spatial working memory function were tested by the n⁃back test. Pearson correlation analysis and Spearman rank correlation analysis were used to investigate the correlation between olfactory function with cognitive function and motor symptoms in patients with PD. Results CSIT⁃self score (Z=⁃2.081, P=0.037) and CSIT⁃OI score (t=13.966, P=0.000) were lower in patients with anosmia than in those with normal smell. Overall MoCA score (t=3.008, P=0.003), as well as the scores of visuospatial executive function (Z=⁃2.277, P=0.023), naming (Z=⁃2.397, P=0.017), attention (Z=⁃3.203, P=0.001), language (Z=⁃2.229, P=0.026), delayed memory (Z=⁃2.426, P=0.015) were all decreased. The accuracy of 1⁃back test (t=2.341, P=0.027) and 2⁃back test (t=2.406, P=0.024) decreased, and the response time of 0⁃back test (t=⁃2.309, P=0.029) and 2⁃back test (t=⁃2.314, P=0.029) increased. Correlation analysis showed that olfactory function score was positively correlated with total MoCA score (rs=0.298, P=0.000). Conclusions The olfactory function of PD patients is closely related to cognitive function, PD patients with olfactory disorder have poor visual spatial working memory function. Therefore such patients should be paid more attention to cognitive function and visual spatial working memory function.

The high-quality semi-polar (11-22) AlN thin films were grown on m-plane sapphire substrates by hydride vapor phase epitaxy (HVPE). The surface morphology and crystalline quality of the AlN film were greatly influenced by the growth temperature and the substrate miscut angle. As the temperature increased, the grain size on the surface increased and the grain density decreased. In addition, the higher growth temperature also resulted in smaller values of the full width at half maximum (FWHM) of X-ray rocking curves (XRC) when temperature was more than 1,460 °C. At high temperature of 1,530 °C, the introduction of 1° -off miscut angle to the substrate resulted in smooth surface, low density of stacking faults and low FWHM of XRC. The misfit dislocation density was calculated from the tilt angle of epilayer measured by X-ray reciprocal space mappings along [−1−123] AlN. The misfit dislocation density of the sample grown on 1° -off substrates was 6.7 × 105 cm−2. The improvement of crystal quality is believed to be due to the enhancement of adatom mobility at higher temperatures and also the appropriate miscut variation.

We consider the following nonlinear Schrödinger equation involving supercritical growth:

We consider the following Hénon-type problem with critical growth:

Cerebral small-vessel disease (CSVD) is the main cause of vascular cognitive impairment (VCI), and the accumulation of amyloid β-protein (Aβ) may be significantly involved in CSVD-induced VCI. The imbalance between Aβ production and clearance is believed to be an important pathological mechanism of Aβ deposition in Alzheimer disease. In this study, we aimed to disclose the roles of aquaporin 4 (AQP4) and neuroinflammation in CSVD, which were the key factors for Aβ clearance and production, respectively, and the effect of mesenchymal stem cells (MSCs) on Aβ deposition and these two factors. The stroke-prone renovascular hypertensive (RHRSP) rats were grouped and received MSC and MSC + AS1517499 (an inhibitor of pSTAT6). The latter was used to explore the underlying mechanism. The cognitive function, white matter lesions, Aβ expression, expression, and polarity of AQP4, neuroinflammation and the STAT6 pathway were investigated. Compared with sham-operated rats, RHRSP rats showed spatial cognitive impairment, white matter lesions and Aβ deposition. Moreover, AQP4 polarity disorder and neuroinflammatory activation were found, which were linked to Aβ deposition. Treatment with MSCs markedly improved cognitive tasks and reduced Aβ deposition but failed to reduce white-matter lesions. Furthermore, MSCs not only promoted AQP4 polarity but also alleviated neuroinflammation probably through the STAT6 pathway. The present study demonstrated that Aβ deposition, AQP4 polarity disorder and neuroinflammation might be involved in CSVD and the regulatory effects of MSCs on them suggested potential therapeutic value for CSVD.

The study of intangible cultural heritage tourism is of great significance to deeply explore the connotation of intangible cultural heritage and promote the in-depth integration of culture and tourism, and it is necessary to grasp the research trend of intangible cultural heritage tourism. This paper takes 3329 documents selected from the CNKI database and the “Web of ScienceTM Core Collection” database as data samples, and uses Citation Space (CiteSpace software) to conduct metrological analysis to summarize the research situation of Chinese and foreign intangible cultural heritage tourism. The results show that:(1) The research on foreign intangible cultural heritage tourism started 10 years earlier than that in China, and the volume of literature was higher than that in China, and it experienced three stages: the initial period, the rapid development stage, and the deepening and expansion period. Although domestic research started late, the growth rate is fast, from 2008 to 2016, the number of publications caught up with foreign countries, and then entered a period of steady development. (2) In general, domestic and foreign authors have not formed a close cooperation network, foreign authors have partial cooperation, but domestic has not formed a stable core author group. (3) Independent research between domestic research institutions, lack of cooperation, scattered and unbalanced research geographical distribution, lack of cross-regional cooperation, high-yield research institutions are Tarim University, Guilin University of Technology, Guangxi and Xinjiang are the leading places for research. There are many cross-border and cross-regional research institutions in foreign countries. China, the United States and Spain are the research centers, and Sichuan University, Chinese Academy of Sciences and Sun Yat-sen University are the backbone of research. (4) The research on intangible cultural heritage tourism in domestic hot spots mainly includes the development, protection, inheritance and development of intangible cultural heritage tourism, the research on the authenticity and temporal and spatial characteristics of intangible cultural heritage tourism, the research hotspots of foreign intangible cultural heritage tourism focus on the comprehensive attributes of intangible cultural heritage tourism, the impact of the authenticity, sustainable development, management, protection and development of intangible cultural heritage tourism, the development model and the experience summary of intangible cultural heritage tourism in destinations, and the research on the subject’s participation attitude, emotional perception and satisfaction. In short, there are differences in the research of intangible cultural heritage tourism between China and foreign countries, and domestic research should strengthen the collaboration between research institutions and authors, continuously broaden the research content, improve research methods, and make research more scientific and objective.

Brain edema is one of the major causes of fatality and disability associated with injury and neurosurgical procedures. The goal of this study was to evaluate the effect of ulinastatin (UTI), a protease inhibitor, on astrocytes in a rat model of traumatic brain injury (TBI).

Abstract Background Fatty liver is a high incidence of perinatal disease in dairy cows caused by negative energy balance, which seriously threatens the postpartum health and milk production. It has been reported that lysine acetylation plays an important role in substance and energy metabolism. Predictably, most metabolic processes in the liver, as a vital metabolic organ, are subjected to acetylation. Comparative acetylome study were used to quantify the hepatic tissues from the severe fatty liver group and normal group. Combined with bioinformatics analysis, this study provides new insights for the role of acetylation modification in fatty liver disease of dairy cows. Results We identified 1841 differential acetylation sites on 665 proteins. Among of them, 1072 sites on 393 proteins were quantified. Functional enrichment analysis shows that higher acetylated proteins are significantly enriched in energy metabolic pathways, while lower acetylated proteins are significantly enriched in pathways related to immune response, such as drug metabolism and cancer. Among significantly acetylated proteins, many mitochondrial proteins were identified to be interacting with multiple proteins and involving in lipid metabolism. Furthermore, this study identified potential important proteins, such as HADHA, ACAT1, and EHHADH, which may be important regulatory factors through modification of acetylation in the development of fatty liver disease in dairy cows and possible therapeutic targets for NAFLD in human beings. Conclusion This study provided a comprehensive acetylome profile of fatty liver of dairy cows, and revealed important biological pathways associated with protein acetylation occurred in mitochondria, which were involved in the regulation of the pathogenesis of fatty liver disease. Furthermore, potential important proteins, such as HADHA, ACAT1, EHHADH, were predicted to be essential regulators during the pathogenesis of fatty liver disease. The work would contribute to the understanding the pathogenesis of NAFLD, and inspire in the development of new therapeutic strategies for NAFLD.

Recent discoveries in the field of graphene-based heterostructures have led to the demonstration of high-performance photodetectors. However, the studies to date have been largely limited to the heterojunction with a Schottky barrier, restricted by an inevitable compromise between photoresponsivity and photodetectivity. Here, a new class of graphene-based tunneling photodetectors is introduced by inserting the Al2O3 tunneling layer between silicon and graphene. The photocarriers can tunnel through the designed insulator layer which simultaneously blocks the dark current, thus maintaining high photodetectivity with desirable photoresponsivity. We further modulate the thickness of the Al2O3 layer to explore the tunneling mechanism for the photocarriers, in which a photoresponsivity of 0.75 A/W, a high current ratio of 4.8 × 103 and a photodetectivity of 3.1 × 1012 Jones are obtained at a 13.3-nm-thick Al2O3 layer. In addition, the fabrication process is compatible with conventional semiconductor processing, providing further flexibility to large-scale integrated photodetectors with high performance.

The purposes of this study were to analyze the influencing factors of self-directed learning readiness (SDLR) of nursing undergraduates and explore the impacts of learning attitude and self-efficacy on nursing undergraduates.

To examine the best practice evidence of the effectiveness of the flipped classroom (FC) as a burgeoning teaching model on the development of self-directed learning in nursing education.

This meta-analysis aimed to examine the effects of parental involvement in infant care in neonatal intensive care units (NICUs).

The amount of solid waste generated by tourists and the scale of waste sorting points can be used to introduce the capacity of solid waste in the scenic spot. Based on tourism environmental capacity theory, this study based on previous research results, the solid waste carrying capacity of Huangshan Scenic area is calculated. The results show that the carrying capacity of the tourism environment in Huangshan Scenic Area is approaching saturation. According to the result, by providing a basic analysis for the treatment of domestic waste in Huangshan Scenic Area, this study confirms that the sustainable tourism development strategy is needed to everlasting natural resources.