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4 results on '"Linda Jenny Handgaard"'

1. Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors

Author

Bertram Kjerulff, Joseph Dowsett, Rikke Louise Jacobsen, Josephine Gladov, Margit Hørup Larsen, Agnete Troen Lundgaard, Karina Banasik, David Westergaard, Susan Mikkelsen, Khoa Manh Dinh, Lotte Hindhede, Kathrine Agergård Kaspersen, Michael Schwinn, Anders Juul, Betina Poulsen, Birgitte Lindegaard, Carsten Bøcker Pedersen, Clive Eric Sabel, Henning Bundgaard, Henriette Svarre Nielsen, Janne Amstrup Møller, Jens Kjærgaard Boldsen, Kristoffer Sølvsten Burgdorf, Lars Vedel Kessing, Linda Jenny Handgaard, Lise Wegner Thørner, Maria Didriksen, Mette Nyegaard, Niels Grarup, Niels Ødum, Pär I. Johansson, Poul Jennum, Ruth Frikke-Schmidt, Sanne Schou Berger, Søren Brunak, Søren Jacobsen, Thomas Folkmann Hansen, Tine Kirkeskov Lundquist, Torben Hansen, Torben Lykke Sørensen, Torben Sigsgaard, Kaspar René Nielsen, Mie Topholm Bruun, Henrik Hjalgrim, Henrik Ullum, Klaus Rostgaard, Erik Sørensen, Ole Birger Pedersen, Sisse Rye Ostrowski, and Christian Erikstrup

Subjects
Medicine
Abstract

Abstract Background The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences. Methods A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking. Results Here we show that concentrations of inflammation and vascular stress biomarkers generally increase with higher age, BMI, and smoking. Sex-specific effects are observed for multiple biomarkers. Conclusion This study provides comprehensive information on concentrations of 47 plasma biomarkers in healthy individuals. The study emphasizes that knowledge about biomarker concentrations in healthy individuals is critical for improved understanding of disease pathology and for tailored care and decision support tools.

Published
2024
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2. Combinations of self‐reported rhinitis, conjunctivitis, and asthma predicts IgE sensitization in more than 25,000 Danes

Author

Susan Mikkelsen, Khoa Manh Dinh, Jens Kjærgaard Boldsen, Ole Birger Pedersen, Gitte Juel Holst, Mikkel Steen Petersen, Kathrine Agergård Kaspersen, Bjarne Kuno Møller, Kaspar Rene Nielsen, Helene Martina Paarup, Klaus Rostgaard, Henrik Hjalgrim, Erik Sørensen, Linda Jenny Handgaard, Thomas Folkmann Hansen, Karina Banasik, Kristoffer Sølvsten Burgdorf, Henrik Ullum, Torben Sigsgaard, and Christian Erikstrup

Subjects
allergic IgE sensitization, asthma, conjunctivitis, environment, rhinitis, Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma composing multiple phenotypes and improved understanding of these phenotypes and their respective risk factors are needed. Objectives The objective of this study was to define the prevalence of AR, AC, and asthma and their association with allergen‐specific immunoglobulin E (sIgE) sensitization in a large cohort of blood donors and identify risk factors. Methods From the nationwide population‐based Danish Blood Donor Study, 52,976 participants completed an electronic questionnaire including AR, AC, asthma, allergic predisposition, and childhood residence. Of these, 25,257 were additionally tested for sIgE to inhalation allergens (Phadiatop). Results The prevalence of sIgE sensitization, AR, AC, and asthma was 30%, 19%, 15%, and 9%, respectively. The youngest birth cohorts had the highest prevalence of sIgE sensitization and symptoms of asthma, AR, and AC, and for asthma, they apparently experienced symptoms at an earlier age. The sIgE sensitization was positively associated with male sex. The sIgE seroprevalence was higher in participants with both AR and AC (ARC) than in participants with either AR or AC. Allergic predisposition and sIgE sensitization increased the risk of the diseases, while farm upbringing was associated with reduced prevalence of ARC, however, only in sIgE sensitized participants. Conclusion Birth year, childhood residence, sIgE sensitization, and allergic predisposition were associated with asthma, AR, and AC prevalence. Individuals with self‐reported ARC represent a primarily sIgE‐positive phenotype, while those with either AR or AC represent more diverse phenotypes.

Published
2021
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3. Atopic respiratory diseases and IgE sensitization are associated with leukocyte subset concentrations in 14,440 blood donors

Author

Christian Erikstrup, Jens Kjærgaard Boldsen, Kathrine Agergård Kaspersen, Susan Mikkelsen, Khoa Manh Dinh, Klaus Rostgaard, Linda Jenny Handgaard, Lise Wegner Thørner, Sisse R. Ostrowski, Bjarne Kuno Møller, Ole Birger Pedersen, Mikkel Steen Petersen, and Torben Sigsgaard

Subjects
0301 basic medicine, Hypersensitivity, Immediate, Platelets, Allergy, Clinical Biochemistry, Blood Donors, Immunoglobulin E, Biochemistry, Allergic conjunctivitis, Allergic rhinitis, 03 medical and health sciences, 0302 clinical medicine, Immune system, immune system diseases, Wheeze, medicine, Humans, Allergic IgE sensitization, Peripheral blood leukocytes, Asthma, Inhalation, biology, business.industry, Biochemistry (medical), General Medicine, Eosinophil, Allergens, medicine.disease, Rhinitis, Allergic, respiratory tract diseases, Eosinophils, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Immunology, biology.protein, medicine.symptom, business
Abstract

Background and aims Allergic rhinitis (AR), allergic conjunctivitis (AC), and asthma are characterized by activation of the immune system. The aim of this study was to explore the long-term association between AR, AC, asthma, and specific immunoglobulin E (IgE) and blood platelet and leukocyte differential counts. Material and methods In the Danish Blood Donor Study, 14,440 participants from Central Denmark Region had platelet and leukocyte differential counts available and completed a questionnaire regarding AR, AC, and asthma. Of these participants, 8485 were tested for IgE to inhalation allergens. Results The prevalence of AR, AC, asthma, and IgE sensitization was 19%, 15%, 9%, and 29%, respectively. AR, AC, asthma, wheeze, and IgE sensitization was associated with increased blood eosinophil concentration even in IgE sensitized participants who did not report any allergy or asthma. The strongest associations were observed for participants with current disease. We found no differences in eosinophil concentration between months without symptoms and months with symptoms of AR and asthma. Conclusion AR, AC, asthma, wheezing, and IgE sensitization to inhalation allergens are associated with increased eosinophil concentration. This may reflect a persistent inflammation even in periods without symptomatic disease.

Published
2021

4. The donors perceived positive and negative effects of blood donation

Author

Helene M. Paarup, Kristoffer Sølvsten Burgdorf, Janni Teglkamp, Henrik Hjalgrim, Andreas S. Rigas, Henrik Ullum, Linda Jenny Handgaard, Christian Erikstrup, Thomas Hansen, Ole Birger Pedersen, and Susan Mikkelsen

Subjects
Adult, Male, medicine.medical_specialty, media_common.quotation_subject, Immunology, Emotions, Blood Donors, 030204 cardiovascular system & hematology, Logistic regression, Dizziness, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Internal medicine, Surveys and Questionnaires, medicine, Immunology and Allergy, Humans, Young adult, media_common, business.industry, Hematology, Middle Aged, Blood donor, Logistic Models, Feeling, Donation, Smoking status, Female, business, Body mass index, 030215 immunology
Abstract

BACKGROUND: Occasionally blood donation has a negative influence on some donors, while others express feelings of increased energy or wellbeing after donation. Some donors even report symptoms such as headache or feelings of unease indicating “it is time to donate blood again.” This study aims to determine symptoms and frequencies of blood donors experiencing positive and negative effects of blood donation, and study possible associations with sex, age, body mass index, smoking status, and hemoglobin level. STUDY DESIGN AND METHODS: We developed and validated a questionnaire with eight predefined physical and psychological symptoms related to blood donation using a 5-point Likert Scale. Participants in The Danish Blood Donor Study were asked to indicate if they experienced the present symptom prior to and/or after the donation. RESULTS: A total of 6,073 donors were included. Of the donors, 61% experienced one or more effects of blood donation. Positive effects were experienced by 18% of the donors, 29% experienced negative effects, and 14% experienced both. Most notable positive effects were alleviated headache (14%), feeling lighter (14%), and less tiredness (7%). Most notable negative effects were less energy (25%), more dizziness (22%), and more tiredness (21%). Logistic regression analysis revealed that positive effects were more likely among donors with higher BMI, older donors, and smokers. Negative effects were more likely among younger donors, donors with lower BMI, and among female donors. CONCLUSION: Analyses indicate that susceptibility to blood donation effects varies by BMI, sex, smoking status, and age, and therefore should be taken into consideration when informing donors about potential effects of blood donation.

Published
2020

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