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Abstract Background Pre-clinical data suggests a potential synergistic effect of eribulin and platinum. However, clinical data on the combination for metastatic breast cancer (mBC) is lacking. We evaluated the efficacy and safety of eribulin plus carboplatin (ErCb) in patients with mBC. Patients and methods This multicenter, real-world cohort study included patients with pre-treated metastatic triple negative breast cancer (TNBC) or endocrine-refractory hormone receptor (HR) positive, HER2-negative mBC who received ErCb. Eribulin (1.4 mg/m2) and carboplatin (target AUC = 2) were administered intravenously on day 1 and 8 of 21-day cycle. Objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and adverse events (AEs) were evaluated. Results From March 2022 to December 2023, a cohort of 37 patients were recruited to the study. Among them, 22 patients have TNBC and 15 have HR + HER2 − mBC. Of the 22 patients with TNBC, 8 had an initial diagnosis of the HR + HER2 − subtype. The median treatment was 6 cycles (range, 2 − 8 cycles). In the full cohort, TNBC, and HR + HER2 − subgroup, the ORR were 51.4%, 54.5% and 46.7%, the DCR were 81.1%, 81.8% and 80%, and the median PFS were 5 months, 5 months, and 5.2 months, respectively. The median OS was 12.7 months in the entire cohort and 12.8 months in TNBC subgroup. The most common grade 3/4 hematological AEs were neutropenia (37.8%), leukopenia (35.1%), febrile neutropenia (10.8%), thrombocytopenia (5.4%), and anemia (2.7%). No grade 3/4 non-hematological AEs were observed. Conclusion ErCb demonstrated favorable efficacy and tolerability in patients with heavily pre-treated mBC, especially TNBC. The findings of the current study warrant further investigation of the application of this combination in earlier lines of mBC treatment.

Abstract Tungsten bronze transitional metal oxides are potential candidate anode material for lithium‐ion batteries (LIBs) owing to their open multichannel frame structure facilitating lithium transport and storage. Herein, the molybdenum reduction and oxygen deficiency are enhanced in micrometer‐scale Mo5O14‐type tungsten bronze structure Mo3Nb2O14−x (V‐MNO) that is prepared by a solid‐state reaction in vacuum. Neutron powder diffraction data indicate that oxygen vacancies are located at both three‐coordinated (µ3) oxygen sites around filled pentagonal rings and normally two‐coordinated (µ2) oxygen sites. As anode material for LIBs, benefiting from the increased Mo reduction, facilitating the electronic transport and oxygen vacancies without strong site preferences, widening the intratunnel, and opening up the intertunnel migration paths for lithium ions, V‐MNO displays enhanced electrochemical properties with an initial discharge capacity of ≈322 mAh g−1, a charge capacity of ≈274 mAh g−1, and a reversible capacity of ≈147.2 mAh g−1 (at 400 mA g−1) after 200 cycles. The LiCoO2//V‐MNO full cell shows a discharge capacity of 145.4 mAh g−1 after 100 cycles at 100 mA g−1. These results underline significance of controlling defect chemistry on the cationic reduction and oxygen vacancies in micrometer‐scale tungsten bronze transition metal oxides as an effective strategy for enhancing their storage performance as anode materials.

It is a major challenge to effectively inhibit microbial pathogens in the treatment of infectious diseases. Research on the application of nanomaterials as antibacterial agents has evidenced their great potential for the remedy of infectious disease. Among these nanomaterials, carbon quantum dots (CQDs) have attracted much attention owing to their unique optical properties and high biosafety. In this work, P-doped CQDs were prepared by simple hydrothermal treatment of m-aminophenol and phosphoric acid with fluorescence emission at 501 nm when excited at 429 nm. The P-doped CQDs showed effective antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The minimal inhibitory concentrations (MICs) of P-doped CQD were 1.23 mg/mL for E. coli and 1.44 mg/mL for S. aureus. Furthermore, the morphologies of E. coli cells were damaged and S. aureus became irregular when treated with the P-doped CQDs. The results of zeta potential analysis demonstrated that the P-doped CQDs inhibit antibacterial activity and destroy the structure of bacteria by electronic interaction. In combination, the results of this study indicate that the as-prepared P-doped CQDs can be a promising candidate for the treatment of bacterial infections.

Image decomposition is an important issue in image processing. The existing approaches including the bi‐dimensional empirical mode decomposition (BEMD) still fail to separate monocomponents in multicomponents in many cases. To solve this problem, this study proposes a new image decomposition method based on the new derived combined bi‐dimensional Bedrosian's principle that has not been reported anywhere else for image processing. First, this study investigates a few bi‐dimensional Bedrosian's principles according to the bi‐dimensional Hilbert transforms. Second, based on the derived bi‐dimensional Bedrosian's principles and the original multicomponents, the authors provide the combined bi‐dimensional Bedrosian's principle and the assisted components obtained through projections via optimisation so that these monocomponents in multicomponents can be separated in the case that the existing methods fail. Third, an iterative image decomposition method is proposed via the above principles to decompose the multicomponent image into true monocomponents. The proposed method can solve the problems caused by the cross‐angle and amplitude ratio and frequency ratio between these components that BEMD fails to solve. Also, the phase and amplitude are estimated for texture analysis after the decomposition is demonstrated. Experiments are shown to support the proposed methods. [ABSTRACT FROM AUTHOR]

In this study, the authors investigated some new inequalities on sparse representation for pairs of bases and frames, which would enrich the theory ensemble. First, for fixed pairs of bases, frames and the signal to be represented, we presented the bounds (which can be used in practice directly) of l0 ‐norm of signal coefficients by the max/min cross‐inner‐products, as is of much importance to bases and frames selections in sparse representation. Also, the error bounds associated with the given min cross‐inner‐products are achieved. Moreover, the equivalence condition between l0 solution and l1 solution was achieved via relations of cross‐inner‐products, as can be applied directly for selection of optimal bases. Finally, the estimation of the parameters of cross‐inner‐products was shown. [ABSTRACT FROM AUTHOR]