92 results on '"Liang, Pang"'
Search Results
2. Association between metallic implants and stroke in US adults from NHANES 2015–2023 a cross-sectional study
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Kai Wu, Liang Pang, Pingping Su, and Cunxian Lv
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metal implants ,stroke ,cross-sectional study ,NHANES ,risk factors ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
ObjectiveMetal implants play a vital role in orthopedic treatment and are widely used in fracture repair, joint replacement and spinal surgery. Although these implants often contain key elements such as chromium (Cr), their potential health effects, particularly their association with stroke risk, have not been fully elucidated. This study aimed to evaluate the association between metallic implants and stroke.MethodsUsing data from the 2015 to 2023 National Health and Nutrition Examination Survey (NHANES), we conducted a cross-sectional analysis of 12,337 US adults, in which 3,699 participants reported having metal implants and 8,638 without. Implant-like.ResultsThrough logistic regression analysis, we revealed a significant positive association between metallic implants and stroke risk (adjusted OR = 1.458, 95%CI (1.130, 1.881), p = 0.004). Further stratified analysis found that this positive association was more significant among older and less physically active participants.ConclusionFindings suggest that metallic implants may be associated with an increased risk of stroke, but given the inherent limitations of cross-sectional studies, this study cannot establish causality.
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- 2024
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3. Characterization and phylogenetic analysis of the complete chloroplast genome of Carpesium lipskyi (Asteraceae, Inuleae)
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Tingyu Li, Hui Chen, Xinyu Chen, Tianmeng Qu, Xinyi Zheng, Liang Pang, Xianhua Gu, and Zhixi Fu
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Carpesium lipskyi ,complete chloroplast genome ,phylogenetic relationship ,Asteraceae ,Genetics ,QH426-470 - Abstract
The species of Carpesium lipskyi C.Winkl. 1998 is an important traditional Chinese medicine in China. In this study, the complete chloroplast (cp) genome of C. lipskyi was determined and analyzed. The result showed that the complete cp genome of C. lipskyi was 151,244 bp in length, consisting of a large single-copy (LSC) region of 82,908 bp, a small single-copy (SSC) region of 18,430 bp, and a pair of inverted repeats (IRs) of 24,953 bp. The overall GC content of the C. lipskyi is 37.68%. The species of C. lipskyi possessed 127 genes, including 83 protein-coding genes, 36 transfer RNA genes, and eight ribosomal RNA genes. The present study found that Inula is sister groups with the closest genetic relationship. The obtained knowledge could provide useful information for future phylogenetic, taxonomic, and evolutionary studies on Inuleae.
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- 2024
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4. Analytical and experimental analysis of concrete temperature and energy considering open-air environmental variations
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Wen-Jian Yang, Peng Li, Li Zhuo, Ming-Liang Pang, Hong-Qiang Xie, and Ming-Li Xiao
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Concrete temperature ,Analytical model ,Environmental factors ,Solar radiation ,Longwave radiation ,Medicine ,Science - Abstract
Abstract Longwave radiation is an important open-air environmental factor that can significantly affect the temperature of concrete, but it has often been ignored in the temperature analysis of open-air concrete structures. In this article, an improved analytical model of concrete temperature was proposed by considering solar radiation, thermal convection, thermal conduction and especially longwave radiation. Temperature monitoring of an open-air concrete block was carried out to verify the proposed model and analyze the heat energy characteristics of open-air concrete. As demonstrated by the open-air experiment, under the influence of longwave radiation, the temperature at the top of the concrete block could decrease rapidly at night and even become lower than the minimum temperature at its bottom. Compared with the analytical model that ignores longwave radiation, the improved model that includes it better matches the measured temperature. According to the energy analysis, although solar radiation controls the transient variation in heat energy, the heat exchange caused by longwave radiation were more than that caused by convection on sunlit surfaces, which indicates the importance of considering longwave radiation.
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- 2024
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5. Bibliometric and visual analysis of membranous nephropathy literature from 2010 to 2023
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Yirui Chen, Chen Liu, Hongnan Shen, Pingping Su, Liang Pang, Congcong Zeng, and Jinguo Cheng
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membranous nephropathy ,membranous glomerulonephritis ,a2 receptor antibody ,bibliometric analysis ,citespace ,VOSviewer ,Therapeutics. Pharmacology ,RM1-950 - Abstract
BackgroundMembranous glomerulonephritis, also known as membranous nephropathy (MN), is a common cause of nephrotic syndrome in adults. Despite extensive research on MN, bibliometric studies on the subject are scarce. Therefore, this study aimed to provide a visual analysis of global trends in membranous nephropathy research over the past 13 years.MethodsThis study conducted a bibliometric and visual analysis of global trends in MN research from 2010 to 2023. Articles related to MN were retrieved from the Web of Science Core Collection (WoSCC) database. Tools such as CiteSpace and VOSviewer were utilized to analyze publications, countries, institutions, authors, publishing journals, co-cited references, and keywords to identify the current state and future trends in MN research.ResultsThe analysis encompassed 1,624 publications, showing an annual increase from 2010 to 2023. The People’s Republic of China emerged as the most active country in this field, while France’s Sorbonne Universite and Institut National de la Sante et de la Recherche Medicale (Inserm) led in publication volume among academic institutions. Debiec Hanna stood out as the most prolific author. BMC Nephrology had the highest number of publications, making it the most favored journal in the field. The article with the greatest co-citation intensity was “Primary Membranous Nephropathy,” a review published in 2017.ConclusionThis study shows that there has been increasing interest in membranous nephropathy over the past 13 years. The most frequently encountered keywords were “membranous nephropathy” “nephrotic syndrome,” and “glomerulonephritis.” Analysis of emerging terms indicated that “a2 receptor antibody,” “domain containing 7a,” and “t cell” may remain prominent subjects of research in the forthcoming years. The findings highlight key research trends and areas of interest that can inform researchers, clinicians, and policymakers about the current state of MN research and help guide future research directions and clinical practice.
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- 2024
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6. Effects of quercetin on polycystic ovary syndrome in animal models: a systematic review and meta-analysis
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Pingping Su, Chao Chen, Liang Pang, Kai Wu, and Yun Sun
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Metabolism ,Endocrine ,GLUT4 gene ,Oxidative stress ,Quercetin ,PCOS ,Gynecology and obstetrics ,RG1-991 ,Reproduction ,QH471-489 - Abstract
Abstract Background Metformin is an insulin sensitizer that is widely used for the treatment of insulin resistance in polycystic ovary syndrome patients. However, metformin can cause gastrointestinal side effects. Purpose This study showed that the effects of quercetin are comparable to those of metformin. Therefore, this study aimed to systematically evaluate the efficacy of quercetin in treating PCOS. Methods The present systematic search of the Chinese National Knowledge Infrastructure (CNKI), Wanfang Data Information Site, Chinese Scientific Journals Database (VIP), SinoMed, Web of Science, and PubMed databases was performed from inception until February 2024. The methodological quality was then assessed by SYRCLE’s risk of bias tool, and the data were analyzed by RevMan 5.3 software. Results Ten studies were included in the meta-analysis. Compared with those in the model group, quercetin in the PCOS group had significant effects on reducing fasting insulin serum (FIS) levels (P = 0.0004), fasting blood glucose (FBG) levels (P = 0.01), HOMA-IR levels (P
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- 2024
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7. Mendelian randomization of stroke risk after total hip and knee replacements
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Liang Pang, Zhihui Zheng, Pingping Su, Zhouhengte Xu, Yirui Chen, Zhicheng Liao, Pengcheng Jia, Xiuling Zhang, and Cunxian Lv
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total hip replacement ,total knee replacement ,stroke ,Mendelian randomization ,causality ,triple hypothesis ,Genetics ,QH426-470 - Abstract
ObjectivePrevious epidemiological studies have indicated an increased risk of neurovascular diseases in patients following total hip and knee replacements. However, definitive conclusions regarding the increased risk of stroke post-replacement remain elusive. Therefore, we conducted a two-sample Mendelian randomization study to investigate the causal relationship between total hip and knee replacements and stroke.MethodsWe utilized summary data from publicly available genome-wide association studies (GWAS). Data concerning total hip replacements (THR, N = 319,037) and total knee replacements (TKR, N = 252,041) were sourced from the Genetics of Osteoarthritis (GO) Consortium. Stroke-related data were obtained from the International Stroke Genetics Consortium, encompassing any stroke (AS), any ischemic stroke (AIS), large vessel ischemic stroke (LV-IS), cardioembolic ischemic stroke (CE-IS), and small vessel ischemic stroke (SV-IS). Our primary causal inference method was the inverse variance weighted (IVW) approach, supplemented by weighted median and MR-Egger regression as secondary inference methods. We utilized the MR-PRESSO global test for outlier detection, Cochran’s Q statistic to assess heterogeneity, and assessed the multiplicity and stability of our findings using p-values from MR-PRESSO and MR-Egger regressions, and the leave-one-out method, respectively.ResultsWe identified significant genetic associations between THR and both AS (IVW p = 0.0001, OR = 1.08, 95% CI = 1.04–1.12) and AIS (IVW p = 0.0016, OR = 1.07, 95% CI = 1.03–1.12). Significant associations were also observed between TKR and AS (IVW p = 0.0002, OR = 1.08, 95% CI = 1.04–1.12), as well as AIS (IVW p = 0.0005, OR = 1.15, 95% CI = 1.06–1.24).ConclusionOur findings genetically support an increased risk of stroke following total hip and knee replacements. However, further studies are necessary to elucidate the specific mechanisms underlying stroke episodes post-replacement.
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- 2024
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8. Prediction of clear cell renal cell carcinoma ≤ 4cm: visual assessment of ultrasound characteristics versus ultrasonographic radiomics analysis
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Fan Yang, Dai Zhang, Li-Hui Zhao, Yi-Ran Mao, Jie Mu, Hai-Ling Wang, Liang Pang, Shi-Qiang Yang, Xi Wei, and Chun-Wei Liu
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small renal tumor ,clear cell renal cell carcinoma ,ultrasound ,radiomics ,renal angiomyolipoma ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
ObjectiveTo investigate the diagnostic efficacy of the clinical ultrasound imaging model, ultrasonographic radiomics model, and comprehensive model based on ultrasonographic radiomics for the differentiation of small clear cell Renal Cell Carcinoma (ccRCC) and Renal Angiomyolipoma (RAML).MethodsThe clinical, ultrasound, and contrast-enhanced CT(CECT) imaging data of 302 small renal tumors (maximum diameter ≤ 4cm) patients in Tianjin Medical University Cancer Institute and Hospital from June 2018 to June 2022 were retrospectively analyzed, with 182 patients of ccRCC and 120 patients of RAML. The ultrasound images of the largest diameter of renal tumors were manually segmented by ITK-SNAP software, and Pyradiomics (v3.0.1) module in Python 3.8.7 was applied to extract ultrasonographic radiomics features from ROI segmented images. The patients were randomly divided into training and internal validation cohorts in the ratio of 7:3. The Random Forest algorithm of the Sklearn module was applied to construct the clinical ultrasound imaging model, ultrasonographic radiomics model, and comprehensive model. The efficacy of the prediction models was verified in an independent external validation cohort consisting of 69 patients, from 230 small renal tumor patients in two different institutions. The Delong test compared the predictive ability of three models and CECT. Calibration Curve and clinical Decision Curve Analysis were applied to evaluate the model and determine the net benefit to patients.Results491 ultrasonographic radiomics features were extracted from 302 small renal tumor patients, and 9 ultrasonographic radiomics features were finally retained for modeling after regression and dimensionality reduction. In the internal validation cohort, the area under the curve (AUC), sensitivity, specificity, and accuracy of the clinical ultrasound imaging model, ultrasonographic radiomics model, comprehensive model, and CECT were 0.75, 76.7%, 60.0%, 70.0%; 0.80, 85.6%, 61.7%, 76.0%; 0.88, 90.6%, 76.7%, 85.0% and 0.90, 92.6%, 88.9%, 91.1%, respectively. In the external validation cohort, AUC, sensitivity, specificity, and accuracy of the three models and CECT were 0.73, 67.5%, 69.1%, 68.3%; 0.89, 86.7%, 80.0%, 83.5%; 0.90, 85.0%, 85.5%, 85.2% and 0.91, 94.6%, 88.3%, 91.3%, respectively. The DeLong test showed no significant difference between the clinical ultrasound imaging model and the ultrasonographic radiomics model (Z=-1.287, P=0.198). The comprehensive model showed superior diagnostic performance than the ultrasonographic radiomics model (Z=4. 394, P
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- 2024
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9. Complete chloroplast genomes of two Ainsliaea species and the phylogenetic analysis in the tribe Pertyeae
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Xinyu Chen, Yifan Feng, Tianmeng Qu, Hui Chen, Xiaofeng Liu, Liang Pang, Ming Chen, and Zhixi Fu
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Ainsliaea ,Pertyeae ,chloroplast genome ,genome comparative analysis ,phylogeny ,Genetics ,QH426-470 - Abstract
The genus Ainsliaea DC. is one of the major groups within the tribe Pertyeae (Asteraceae). It comprises several important Chinese medicinal species. However, the phylogenetic position has undergone a long process of exploration. The complete chloroplast (cp) genome sequences data has not been employed in species identification and phylogeny of Ainsliaea. In this study, the complete cp genomes of two Ainsliaea species (A. gracilis and A. henryi) were reported, followed by structural, comparative, and phylogenetic analyses within the tribe Peryteae. Both cp genomes displayed a typical quadripartite circular structure, with the LSC and SSC regions separated by the IR regions. The genomes were 152,959 (A. gracilis) and 152,805 (A. henryi) base pairs (bp) long, with a GC content of 37.6%. They were highly conserved, containing 134 genes, including 87 protein-coding genes, 37 tRNA genes, 8 rRNA genes, and 2 pseudogenes (rps19 and ycf1). Moreover, thirteen highly polymorphic regions (e.g., trnK-UUU, trnG-UCC, trnT-GGU, accD-psaI, and rpl22-rps19) were identified, indicating their potential as DNA barcodes. The phylogenetic analysis confirmed the placement of Ainsliaea in the tribe Pertyeae, revealing close relationships with the genera Myripnois and Pertya. In comparison with Ainsliaea, Myripnois was more closely related to Pertya. This study lays a theoretical foundation for future research on species identification, population genetics, resource conservation, and sustainable utilization within Ainsliaea and Pertyeae.
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- 2024
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10. Yield estimation of North Korean underground nuclear tests using Lg-wave source spectra
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Yu Lu, Lian-Feng Zhao, Xin-Liang Pang, and Zhen-Xing Yao
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seismic attenuation ,Lg source spectra ,yield estimation ,underground nuclear tests ,the Korean Peninsula ,Science - Abstract
In seismic nuclear monitoring, attenuation models are important prerequisites for reliably estimating the explosive yield in an uncalibrated region without the occurrence of standard events. The seismic moment obtained by fitting source spectra is related to the source energy. This approach is appropriate for estimating yield, as the attenuation effects on the propagation path can be accurately considered. In this study, we collected 2022 vertical component waveforms in and around the Korean Peninsula from May 2010 to May 2022 to construct a high-resolution broadband Lg-wave attenuation model and inverted the Lg-wave source excitation spectra of the nuclear explosion simultaneously with attenuation correction. We obtained the scalar seismic moments by fitting the theoretical source spectra based on the Brune (J. Geophys. Res., 1970, 75, 4997–5009) model. Under the given emplacement conditions and burial depths, the seismic moments can be used to estimate yields of the North Korean nuclear tests, which are 4.6, 8.5, 19.9, 20.9, 24.7, and 337.4 kt for six nuclear explosions that occurred between 2006 and 2017. Our results are consistent with those obtained from previous teleseismic observations.
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- 2024
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11. Targeted drug delivery of engineered mesenchymal stem/stromal-cell-derived exosomes in cardiovascular disease: recent trends and future perspectives
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Jian-Liang Pang, Hong Shao, Xiao-Gang Xu, Zhi-Wei Lin, Xiao-Yi Chen, Jin-Yang Chen, Xiao-Zhou Mou, and Pei-Yang Hu
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targeted drug delivery ,exosome ,cardiovascular disease ,mesenchymal stem cells ,extracellular vesicles ,Biotechnology ,TP248.13-248.65 - Abstract
In recent years, stem cells and their secretomes, notably exosomes, have received considerable attention in biomedical applications. Exosomes are cellular secretomes used for intercellular communication. They perform the function of intercellular messengers by facilitating the transport of proteins, lipids, nucleic acids, and therapeutic substances. Their biocompatibility, minimal immunogenicity, targetability, stability, and engineerable characteristics have additionally led to their application as drug delivery vehicles. The therapeutic efficacy of exosomes can be improved through surface modification employing functional molecules, including aptamers, antibodies, and peptides. Given their potential as targeted delivery vehicles to enhance the efficiency of treatment while minimizing adverse effects, exosomes exhibit considerable promise. Stem cells are considered advantageous sources of exosomes due to their distinctive characteristics, including regenerative and self-renewal capabilities, which make them well-suited for transplantation into injured tissues, hence promoting tissue regeneration. However, there are notable obstacles that need to be addressed, including immune rejection and ethical problems. Exosomes produced from stem cells have been thoroughly studied as a cell-free strategy that avoids many of the difficulties involved with cell-based therapy for tissue regeneration and cancer treatment. This review provides an in-depth summary and analysis of the existing knowledge regarding exosomes, including their engineering and cardiovascular disease (CVD) treatment applications.
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- 2024
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12. Social inequality of urban park use during the COVID-19 pandemic
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Ling Yu, Pengjun Zhao, Junqing Tang, Liang Pang, and Zhaoya Gong
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History of scholarship and learning. The humanities ,AZ20-999 ,Social Sciences - Abstract
Abstract Although many studies have examined social inequalities related to urban parks, there is limited knowledge about the social inequalities of urban park use during crises. By integrating a large amount of mobile phone data and e-commerce user data, this study tracked 81,350 anonymized individuals’ urban park use behavior in Shenzhen, China, from 2019 to 2021, covering a period before and after the start of the COVID-19 pandemic. Results reveal that while most of the parks saw a reduction of over 50% in the number of visitors, some parks, especially relatively small and remote parks, had more visitors after the pandemic began than before. In addition, COVID-19 has caused residents’ urban parks use time to decrease and such impacts are more severe in vulnerable groups (e.g., females, the elderly, juveniles, and low-income groups). Moreover, there are significant inequalities in urban park use between rich and poor communities, and COVID-19 has slightly exacerbated these inequalities. The study highlighted that integrating mobile phone data with e-commerce data is an effective way to unveil the complex social inequalities behind human behavior. Findings could help to improve social equality in urban park use as well as providing insights for evidence-informed decision-making in post-pandemic recovery and future crises.
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- 2023
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13. Influence of excitation current on electromagnetic vibration and noise of rotor magnetic shunt hybrid excitation synchronous motor
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Qingliang Yang, Liang Pang, Hebiao Shen, Haihong Qin, and Chaohui Zhao
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Hybrid excitation ,Rotor magnetic shunt ,Field current ,Electromagnetic vibration noise ,Finite element simulation ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
To explore the influence of the excitation current in the rotor magnetic shunt hybrid excitation synchronous motor (HESM) on the vibration and noise of the motor, the finite element analysis of the hybrid excitation motor was carried out by using ANSYS Workbench software and noise sources for analysis. Firstly, air-gap flux density at different excitation currents and density vector diagrams are studied. Secondly, radial electromagnetic force’s order and frequency characteristics under different excitation currents are discussed. Finally, the modal analysis of the stator of the motor is carried out. The motor’s vibration response and noise variation under different excitation current conditions are summarized. The simulation analysis and experimental verify that the motor’s vibration response and noise increase obviously when the excitation current is significant, and the vibration acceleration of different orders increases.
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- 2022
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14. Research on vibration and noise of magnetic pole eccentricity tangential magnetizing parallel structure hybrid excitation synchronous motor
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Liang Pang, Qingliang Yang, Hebiao Shen, Haihong Qin, and Chaohui Zhao
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Hybrid excitation ,Tangential magnetizing ,Magnetic pole eccentricity ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
In order to research vibration and noise of TMPS-HESM. The Magnetic pole eccentricity TMPS-HESM is established. The order and frequency characteristics of radial electromagnetic force are discussed The vibration and noise coupling model is built by ANSYS Workbench simulation platform. The vibration response and noise variation are discussed. The results show that magnetic pole eccentricity can effectively reduce air gap flux density harmonic content, and third harmonic is significantly decreased. The excitation current will significantly affect the harmonic (8,2f1), (16,4f1), (0,12f1) components of radial electromagnetic force of magnetic pole eccentricity TMPS-HESM. Although the (0,12f1) component is not the same order of magnitude as other components, it will still worsen the vibration noise of the motor.
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- 2022
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15. POMS and eye movement: Two indicators for performance in athletics
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Liang Pang, Xinyi Xie, and Yigang Lin
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Track or field ,POMS ,Emotional pictures ,Eye movement ,Performance ,College students ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Background: Regularly and scientifically participating in athletics is beneficial for physical and mental health. Mood or emotions are important component of psychology and a major indicator of physical and mental health. Positive and negative mood or emotions can have a strong impact on physical responsiveness. The aim of the present study was to explore whether mood or emotional state influence performance in athletics. Methods: Mood, analyzed by Profile of Mood States, and emotional state, reflected by eye movement (looking at times and length), were used to predict track or field performance in training and competition. Results: 1. The profile of track training (except 3rd week) resembled an iceberg profile (highest vigor scores) and the profile on the 3rd week resembled a “melting” iceberg profile, in which positive mood (vigor and self-esteem) was decreased and negative mood, particularly depression and anger, was significantly increased. The profile of field training almost overlapped, with the exception of depression decreasing markedly on the 3rd and 4th weeks. 2. Positive mood overpowered negative mood, particularly following a track competition; positive emotions exceed negative emotions following track and field competition. 3. The results of the regression analysis showed that an improvement in track performance was negatively correlated with a rise in total mood disturbance (TMD), and field performances were positively correlated with positivity of emotion, as tested by eye movement. 4. Good performance in track events appeared to be associated with decreased vigor and increased fatigue during 3rd and 4th track training; decreased depression and fatigue, and increased vigor as well as low observe length of watching negative emotional pictures (NEPs) before track competition. A good performance in field events appeared to be associated with anger decrease and confusion increase, increased fixation counts of watching positive emotional pictures (PEPs), and decreased fixation and observe counts of watching NEPs before field competition. Conclusions: The present study proved that different indicators appeared to measure different sport performances: More indicators of Profile of Mood States inclined to predict track performance, while more eye movement indicators could predict field performance. Mixed methods could provide a better understanding of performance than a single approach alone. These findings provided theoretical support and supplementary data for practical applications in the design of comprehensive training programs.
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- 2023
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16. The impact of consumer perceived value on repeat purchase intention based on online reviews: by the method of text mining
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Ning Zhang, Rong Liu, Xiao-Yang Zhang, and Zhi-Liang Pang
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Sharing economy ,Peer-to-peer accommodation ,Repeat purchase intention ,LDA topic model ,Sentiment analytics ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
The progress of IT technology such as social network and mobile payment and the change of social economic environment promote the emergence of sharing economy. As a subversive business model, the sharing economy is growing at an alarming rate all over the world. However, the influencing factors of consumers' continuous participation in the sharing economy are not clear. The paper aims to clarify the relationship between consumer perceived value and repeat purchase intention in the sharing economy. Taking the sharing economy platform (Airbnb) as an example, it proposes a dimension framework of consumer perceived value in peer-to-peer (P2P) accommodation rental service, including functional value, hedonic value, epistemic value and social relationship value. This paper used big data technology to crawl online reviews of P2P accommodation platform. LDA (Latent Dirichlet Allocation) topic model and sentiment analytics method were applied to construct the measurement indicators of perceived value based on online reviews. And repeat purchase intention variables were extracted from online reviews. Then structural equation model was used to examine the effect of perceived value dimensions on it. The paper identified that perceived value has a positive impact on consumers' repurchase intention in P2P accommodation. Also, social relationship value was considered as the most important influencing factor.
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- 2021
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17. A Spline-High Dimensional Model Representation for SRAM Yield Estimation in High Sigma and High Dimensional Scenarios
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Liang Pang, Shan Shen, and Mengyun Yao
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Yield analysis ,SRAM ,importance sampling ,SP-HDMR model ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
Traditional Static Random-Access Memory (SRAM) yield estimation through Monte Carlo analysis is an extremely time-consuming process since it runs millions of expensive transistor-level simulations to get the yield results with the specified precision, especially for the large-scale circuits. In this paper, we develop an efficient yield analysis framework by integrating our novel performance metamodel into a state-of-art importance sampling method. The performance meta-model, named Spline-High Dimensional Model Representation (SP-HDMR), is used to substitute the expensive transistor-level simulations in yield estimation. The proposed SP-HDMR model provides a high computationally efficient formula expansion. It uses spline functions as the kernels to describe the various relations between the process parameters and SRAM read access delay. And an adaptive sampling method with sparsity analysis is developed to support SP-HDMR modeling. The experiments on the 40nm SRAM circuits validate the accuracy and the efficiency of the proposed yield analysis framework based on our SP-HDMR model with 1.3X $\sim 5\text{X}$ speedup over the other state-of-art methods within 9% relative error.
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- 2021
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18. Research on a Precision Calibration Model of a Flexible Strain Sensor Based on a Variable Section Cantilever Beam
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Qi Wang, Jianjun Cui, Yanhong Tang, Liang Pang, Kai Chen, and Baowu Zhang
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flexible sensor ,variable section cantilever beam ,large deflection ,strain ,calibration model ,Chemical technology ,TP1-1185 - Abstract
The flexible strain sensor’s measuring range is usually over 5000 με, while the conventional variable section cantilever calibration model has a measuring range within 1000 με. In order to satisfy the calibration requirements of flexible strain sensors, a new measurement model was proposed to solve the inaccurate calculation problem of the theoretical strain value when the linear model of a variable section cantilever beam was applied to a large range. The nonlinear relationship between deflection and strain was established. The finite element analysis of a variable section cantilever beam with ANSYS shows that the linear model’s relative deviation is as high as 6% at 5000 με, while the relative deviation of the nonlinear model is only 0.2%. The relative expansion uncertainty of the flexible resistance strain sensor is 0.365% (k = 2). Simulation and experimental results show that this method solves the imprecision of the theoretical model effectively and realizes the accurate calibration of a large range of strain sensors. The research results enrich the measurement models and calibration models for flexible strain sensors and contribute to the development of strain metering.
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- 2023
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19. Effects of oxiracetam combined with ginkgo biloba extract in the treatment of acute intracerebral hemorrhage: A clinical study
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Xiu‐Xiu Li, Shi‐Hui Liu, Su‐Jing Zhuang, Shi‐Feng Guo, and Shou‐Liang Pang
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acute intracerebral hemorrhage ,ginkgo biloba extract ,oxiracetam ,routine treatment ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Purpose The present clinical study was conducted to investigate the effect of oxiracetam combined with ginkgo biloba extract in treating patients with acute intracerebral hemorrhage. Methods Ninety‐eight patients with acute cerebral hemorrhage admitted to our hospital were divided into three groups. The differences of brain edema and cerebral hemorrhage were compared between the three groups after 1 and 2 weeks of treatment, and the recovery of neurological function, serum inflammatory factors, AQP‐4, MMP‐9, cognitive function, activities of daily living, and adverse reactions were compared between the three groups after 2 weeks of treatment. Results There was no significant difference among the three groups before treatment (p > .05). After treatment, the recovery of neurological function, serum inflammatory factors, AQP‐4, MMP‐9 levels, cognitive function, and activities of daily living were improved. Among them, the neurological function recovery, serum inflammatory factors, AQP‐4, MMP‐9 levels, cognitive function, and activities of daily living in the combined treatment group and the control group elicited greater results than those in the routine group. The results of the combined treatment group showed the most significant difference (p
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- 2020
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20. NIR-Prompt: A Multi-task Generalized Neural Information Retrieval Training Framework.
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SHICHENG XU, LIANG PANG, HUAWEI SHEN, and XUEQI CHENG
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The article introduces NIR-Prompt, a framework for training neural information retrieval (NIR) models. It aims to improve the generalization ability of pre-trained language models (PLMs) in NIR for various tasks such as document retrieval, question answering, and retrieval-based dialogue. It is reported that NIR-Prompt employs the Essential Matching Module (EMM) to capture essential matching signals and the Matching Description Module (MDM) for task adaptation.
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- 2024
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21. Primary M1 macrophages as multifunctional carrier combined with PLGA nanoparticle delivering anticancer drug for efficient glioma therapy
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Liang Pang, Ying Zhu, Jing Qin, Wenjie Zhao, and Jianxin Wang
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m1 macrophages ,carrier ,glioma ,nanoparticle ,doxorubicin ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Glioma remains difficult to treat because of the infiltrative growth of tumor cells and their resistance to standard therapy. Despite rapid development of targeted drug delivery system, the current therapeutic efficacy is still challenging. Based on our previous studies, macrophages have been proved to be promising drug carrier for active glioma delivery. To make full use of macrophage carrier, primary M1 macrophages were proposed to replace regular macrophage to deliver nanodrugs into glioma, because M1 macrophages not only have the natural ability to home into tumor tissues, but they also have stronger phagocytic capability than other types of macrophage, which can enable them to uptake enough drug-loaded nanoparticles for therapy. In addition, M1 macrophages are not easily affected by harsh tumor microenvironment and inhibit tumor growth themselves. In this study, M1 macrophage-loaded nanoparticles (M1-NPs) were prepared by incubating poly(lactide-co-glycolide) (PLGA) nanoparticles with primary M1 macrophages. In vitro cell assays demonstrated M1 macrophage still maintained good tumor tropism capability after particle loading, and could efficiently carry particles across endothelial barrier into tumor tissues. In vivo imaging verified that M1-NPs exhibited higher brain tumor distribution than free nanoparticles. DOX@M1-NPs (doxorubicin-loaded M1-NPs) presented significantly enhanced anti-glioma effect with prolonged survival median and increased cell apoptosis. In conclusion, the results provided a new strategy exploiting M1 macrophage as carrier for drug delivery, which improved targeting efficiency and therapeutic efficacy of chemodrugs for glioma therapy.
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- 2018
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22. A novel strategy to achieve effective drug delivery: exploit cells as carrier combined with nanoparticles
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Liang Pang, Chun Zhang, Jing Qin, Limei Han, Ruixiang Li, Chao Hong, Huining He, and Jianxin Wang
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red blood cell ,leukocyte ,stem cell ,carrier ,nanoparticle ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Cell-mediated drug delivery systems employ specific cells as drug vehicles to deliver drugs to targeted sites. Therapeutics or imaging agents are loaded into these cells and then released in diseased sites. These specific cells mainly include red blood cells, leukocytes, stem cells and so on. The cell acts as a Trojan horse to transfer the drug from circulating blood to the diseased tissue. In such a system, these cells keep their original properties, which allow them to mimic the migration behavior of specific cells to carry drug to the targeted site after in vivo administration. This strategy elegantly combines the advantages of both carriers, i.e. the adjustability of nanoparticles (NPs) and the natural functions of active cells, which therefore provides a new perspective to challenge current obstacles in drug delivery. This review will describe a fundamental understanding of these cell-based drug delivery systems, and discuss the great potential of combinational application of cell carrier and NPs.
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- 2017
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23. Family Between the Individual and Political Society. A Study On Hobbes's Theory of the Family.
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Liang Pang
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- 2023
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24. Localization of multiple jamming attackers in vehicular ad hoc network
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Liang Pang, Xiao Chen, Yong Shi, Zhi Xue, and Rida Khatoun
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Electronic computers. Computer science ,QA75.5-76.95 - Abstract
In vehicular ad hoc network, wireless jamming attacks are easy to be launched in the control channel and can cause serious influence on the network performance which may cause further safety accidents. In order to address the issue of wireless jamming attacks, a new technique which localizes the jamming attackers and prevents vehicles from jamming through human intervention is proposed. In this article, we propose a range-free approach to localize the source of the attacker and determine the number of jamming attackers. The data set is the locating information and the jamming detection information associated with each vehicle. Then, we formulate the problem of determining the number of attackers as a multiclass detection problem. We define the incorrectly classified area and use it to measure the distance between samples and centroids in fuzzy c-means algorithm. We further determine the number of jamming attackers through the coverage rate of beaconing circles and utilize weight-based fuzzy c-means to classify the data set. When the data set is classified as acceptable, we further explore the means of using particle swarm optimization algorithm to calculate the positional coordinates of each attacker. We simulate our techniques in MATLAB, and both urban traffic area and open area are considered in our simulation. The experimental results suggest that the proposed algorithm can achieve high precision when determining the number of attackers while the result of the classified performance is always satisfying. Our localization results lead to higher accuracy than other existing solutions. Also, when the data set is limited, the chances of taking accurate localization are higher than other measures.
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- 2017
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25. Effects of intravenous thrombolysis with alteplase combined with edaravone on cerebral hemodynamics and T lymphocyte level in patients with acute cerebral infarction
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Su-Jing Zhuang, Shi-Hui Liu, Shi-Feng Guo, Xiu-Xiu Li, and Shou-Liang Pang
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Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,T-Lymphocytes ,Observational Study ,medicine.disease_cause ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Pharmacotherapy ,Randomized controlled trial ,Fibrinolytic Agents ,law ,Internal medicine ,Edaravone ,Medicine ,Humans ,In patient ,Thrombolytic Therapy ,030212 general & internal medicine ,Aged ,edaravone ,business.industry ,Hemodynamics ,General Medicine ,Thrombolysis ,T lymphocyte ,Cerebral Infarction ,intravenous thrombolysis with alteplase ,Middle Aged ,acute cerebral infarction ,Treatment Outcome ,chemistry ,Cerebral hemodynamics ,030220 oncology & carcinogenesis ,Cerebrovascular Circulation ,Tissue Plasminogen Activator ,Acute Disease ,Cardiology ,cerebral hemodynamic indexes ,Administration, Intravenous ,Drug Therapy, Combination ,Female ,business ,Oxidative stress ,Research Article - Abstract
Our study aimed to investigate the effect of intravenous thrombolysis with alteplase and edaravone on cerebral hemodynamics and T lymphocyte level in patients harboring acute cerebral infarction. There involved a total of 118 patients with acute cerebral infarction from November 2017 to May 2019 in our hospital were randomly divided into 2 groups: the observation group (59 patients were treated with intravenous thrombolysis with alteplase combined with edaravone) and the control group (59 patients were treated with intravenous thrombolysis of alteplase). The clinical effect, neurological function, cerebral hemodynamic index, T lymphocyte level, oxygen free radical scavenging level and oxidative stress index of the 2 groups were observed and compared. Before the treatment, there were no significant differences in neurological function, cerebral hemodynamic indexes, T-lymphocyte level, oxygen free radical scavenging level and oxidative stress indexes between the 2 groups (P > .05). After the treatment, the neurological function, cerebral hemodynamic indexes, T-lymphocyte level, oxygen free radical scavenging level and oxidative stress indexes of the 2 groups were significantly improved. In addition, the observation group exerted greater beneficial effect in terms of the clinical effect, neurologic function, cerebral hemodynamic index, T lymphocyte level, oxygen free radical scavenging level and oxidative stress index than those of the control group (P
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- 2020
26. Beyond Language: Learning Commonsense from Images for Reasoning
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Wanqing Cui, Jiafeng Guo, Yanyan Lan, Xueqi Cheng, and Liang Pang
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FOS: Computer and information sciences ,Commonsense knowledge ,Process (engineering) ,Computer science ,Computer Science - Artificial Intelligence ,02 engineering and technology ,Representation (arts) ,010501 environmental sciences ,computer.software_genre ,01 natural sciences ,0202 electrical engineering, electronic engineering, information engineering ,Question answering ,0105 earth and related environmental sciences ,Computer Science - Computation and Language ,business.industry ,Supervised learning ,Commonsense reasoning ,Language acquisition ,Artificial Intelligence (cs.AI) ,020201 artificial intelligence & image processing ,Artificial intelligence ,Language model ,business ,Computation and Language (cs.CL) ,computer ,Natural language processing - Abstract
This paper proposes a novel approach to learn commonsense from images, instead of limited raw texts or costly constructed knowledge bases, for the commonsense reasoning problem in NLP. Our motivation comes from the fact that an image is worth a thousand words, where richer scene information could be leveraged to help distill the commonsense knowledge, which is often hidden in languages. Our approach, namely Loire, consists of two stages. In the first stage, a bi-modal sequence-to-sequence approach is utilized to conduct the scene layout generation task, based on a text representation model ViBERT. In this way, the required visual scene knowledge, such as spatial relations, will be encoded in ViBERT by the supervised learning process with some bi-modal data like COCO. Then ViBERT is concatenated with a pre-trained language model to perform the downstream commonsense reasoning tasks. Experimental results on two commonsense reasoning problems, i.e. commonsense question answering and pronoun resolution, demonstrate that Loire outperforms traditional language-based methods. We also give some case studies to show what knowledge is learned from images and explain how the generated scene layout helps the commonsense reasoning process., Accepted to EMNLP'20 Findings
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- 2020
27. Modeling Topical Relevance for Multi-Turn Dialogue Generation
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Hongshen Chen, Dawei Yin, Hainan Zhang, Yanyan Lan, Liang Pang, and Zhuoye Ding
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FOS: Computer and information sciences ,Computer Science - Machine Learning ,Computer Science - Computation and Language ,Process (engineering) ,business.industry ,Computer science ,Computer Science - Human-Computer Interaction ,Context (language use) ,computer.software_genre ,Human-Computer Interaction (cs.HC) ,Machine Learning (cs.LG) ,Phenomenon ,Metric (mathematics) ,Relevance (information retrieval) ,Artificial intelligence ,Representation (mathematics) ,business ,computer ,Computation and Language (cs.CL) ,Word (computer architecture) ,Natural language processing ,Sentence - Abstract
Topic drift is a common phenomenon in multi-turn dialogue. Therefore, an ideal dialogue generation models should be able to capture the topic information of each context, detect the relevant context, and produce appropriate responses accordingly. However, existing models usually use word or sentence level similarities to detect the relevant contexts, which fail to well capture the topical level relevance. In this paper, we propose a new model, named STAR-BTM, to tackle this problem. Firstly, the Biterm Topic Model is pre-trained on the whole training dataset. Then, the topic level attention weights are computed based on the topic representation of each context. Finally, the attention weights and the topic distribution are utilized in the decoding process to generate the corresponding responses. Experimental results on both Chinese customer services data and English Ubuntu dialogue data show that STAR-BTM significantly outperforms several state-of-the-art methods, in terms of both metric-based and human evaluations.
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- 2020
28. The distance between theoretical and practical leisure activities influenced life satisfaction .
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Liang Pang, Chengcheng Liu, Yigang Lin, and Xinyi Xie
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- *
LEISURE , *RECREATION , *AFFECT (Psychology) , *LIFE satisfaction , *COLLEGE students , *MENTAL health , *WELL-being , *HAPPINESS , *ACADEMIC achievement - Abstract
Recreational activities have acquired the favor and interest of college students and are now essential for their physical and mental well-being. Most activities, including leisure activities, share theoretical and practical elements. This research aims to evaluate a conceptual model about the relationship between leisure attitudes, theoretical and practical leisure, and life satisfaction, as well as to investigate the determinants of life satisfaction. Nine hundred ninety-eight students were sampled and questioned using the "Leisure Values Questionnaire," "Leisure Attitude and Expenses Questionnaire," and "life satisfaction Questionnaire." The outcomes of the primary data were evaluated using a quantitative research strategy based on association and aggressive analysis. The results indicated that the more their preference for leisure activities, the greater their life satisfaction. Those who spend more money and time on leisure activities report greater life satisfaction. Practical leisure was more strongly connected with life satisfaction than theoretical leisure. The predictor for the affective component of life satisfaction was theoretical leisure, while practical leisure was positively associated with the experience component. Meanwhile, positive affect and experience were positively associated with life satisfaction. The study emphasizes the significance of developing a positive attitude toward leisure to increase life satisfaction, supports the significance of leisure favor and practical leisure in achieving life satisfaction, and is helpful for detailed theoretical interpretation and policymakers who develop leisure programs to increase public life satisfaction. [ABSTRACT FROM AUTHOR]
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- 2022
29. [Untitled]Construction and optimization of a composite scaffold for osteochondral tissue engineering
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Tian-zheng, Deng, Jing, Lü, Yan, Feng, Dong-xia, Li, Bing, Liu, Jian-liang, Pang, and Jie, Ke
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- 2012
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30. [Untitled]Construction and optimization of a composite scaffold for osteochondral tissue engineering
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Tian-zheng, Deng, Jing, Lü, Yan, Feng, Dong-xia, Li, Bing, Liu, Jian-liang, Pang, and Jie, Ke
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- 2012
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31. Information Retrieval : 27th China Conference, CCIR 2021, Dalian, China, October 29–31, 2021, Proceedings
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Hongfei Lin, Min Zhang, Liang Pang, Hongfei Lin, Min Zhang, and Liang Pang
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- Information retrieval--Congresses
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This book constitutes the refereed proceedings of the 27th China Conference on Information Retrieval, CCIR 2021, held in Dalian, China, in October 2021.The 15 full papers presented were carefully reviewed and selected from 124 submissions. The papers are organized in topical sections: search and recommendation, NLP for IR, IR in Education, and IR in Biomedicine.
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- 2021
32. [Untitled]Anterior open door decompression of cervical vertebral canal using CT three-dimensional reconstruction and anatomic study: Design and feasibility
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Qing-jun, Zhang, Yu-hua, Hu, Jin-yong, Qian, Chang-feng, Wang, and Liang, Pang
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- 2010
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33. [Untitled]Anterior open door decompression of cervical vertebral canal using CT three-dimensional reconstruction and anatomic study: Design and feasibility
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Qing-jun, Zhang, Yu-hua, Hu, Jin-yong, Qian, Chang-feng, Wang, and Liang, Pang
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- 2010
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34. Primary M1 macrophages as multifunctional carrier combined with PLGA nanoparticle delivering anticancer drug for efficient glioma therapy
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Wenjie Zhao, Zhu Ying, Jianxin Wang, Jing Qin, and Liang Pang
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0301 basic medicine ,Cell Survival ,Drug Compounding ,Pharmaceutical Science ,Antineoplastic Agents ,02 engineering and technology ,doxorubicin ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,Drug Delivery Systems ,Polylactic Acid-Polyglycolic Acid Copolymer ,carrier ,Cell Movement ,Glioma ,Cell Line, Tumor ,glioma ,medicine ,Human Umbilical Vein Endothelial Cells ,Macrophage ,Animals ,Humans ,Doxorubicin ,Tumor microenvironment ,Drug Carriers ,Mice, Inbred BALB C ,Brain Neoplasms ,Macrophages ,nanoparticle ,lcsh:RM1-950 ,General Medicine ,021001 nanoscience & nanotechnology ,medicine.disease ,Survival Analysis ,PLGA ,Drug Liberation ,m1 macrophages ,030104 developmental biology ,lcsh:Therapeutics. Pharmacology ,chemistry ,Targeted drug delivery ,Drug delivery ,Cancer research ,Nanoparticles ,0210 nano-technology ,Drug carrier ,medicine.drug - Abstract
Glioma remains difficult to treat because of the infiltrative growth of tumor cells and their resistance to standard therapy. Despite rapid development of targeted drug delivery system, the current therapeutic efficacy is still challenging. Based on our previous studies, macrophages have been proved to be promising drug carrier for active glioma delivery. To make full use of macrophage carrier, primary M1 macrophages were proposed to replace regular macrophage to deliver nanodrugs into glioma, because M1 macrophages not only have the natural ability to home into tumor tissues, but they also have stronger phagocytic capability than other types of macrophage, which can enable them to uptake enough drug-loaded nanoparticles for therapy. In addition, M1 macrophages are not easily affected by harsh tumor microenvironment and inhibit tumor growth themselves. In this study, M1 macrophage-loaded nanoparticles (M1-NPs) were prepared by incubating poly(lactide-co-glycolide) (PLGA) nanoparticles with primary M1 macrophages. In vitro cell assays demonstrated M1 macrophage still maintained good tumor tropism capability after particle loading, and could efficiently carry particles across endothelial barrier into tumor tissues. In vivo imaging verified that M1-NPs exhibited higher brain tumor distribution than free nanoparticles. DOX@M1-NPs (doxorubicin-loaded M1-NPs) presented significantly enhanced anti-glioma effect with prolonged survival median and increased cell apoptosis. In conclusion, the results provided a new strategy exploiting M1 macrophage as carrier for drug delivery, which improved targeting efficiency and therapeutic efficacy of chemodrugs for glioma therapy.
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- 2018
35. Lactobacillus plantarum KSFY06 and geniposide counteract montmorillonite-induced constipation in Kunming mice
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Jie Liang, Wenjing Diao, Jianfei Mu, Xianrong Zhou, Fang Tan, Liang Pang, Xin Zhao, and Yi Gan
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0301 basic medicine ,Constipation ,mRNA ,Vasoactive intestinal peptide ,Substance P ,lcsh:TX341-641 ,montmorillonite ,Pharmacology ,Motilin ,geniposide ,03 medical and health sciences ,chemistry.chemical_compound ,medicine ,Glial cell line-derived neurotrophic factor ,Gastrin ,Original Research ,030109 nutrition & dietetics ,biology ,Chemistry ,constipation ,biology.organism_classification ,030104 developmental biology ,Somatostatin ,Lactobacillus plantarum ,biology.protein ,medicine.symptom ,lcsh:Nutrition. Foods and food supply ,Food Science - Abstract
Constipation is a common clinical manifestation of digestive system disorders and occurs worldwide. This study investigated the ability of Lactobacillus plantarum KSFY06 (LP‐KSFY06) to promote the action of geniposide in preventing montmorillonite‐induced constipation in Kunming mice, with the aim of providing a successful solution. The effects of LP‐KSFY06 and geniposide on constipation were measured, and the results showed that the protective effect of geniposide on constipation was enhanced by LP‐KSFY06 and that the combination resulted in increased weight, moisture content, and particle number of feces. The first black stool defecation time was decreased from 182 min to 87 min, which clearly indicates that defecating difficulty was alleviated in constipated mice. The synergic intervention of LP‐KSFY06 and geniposide (LP + G) assisted in maintaining the body weight of constipated mice. The LP + G intervention significantly increased serum levels of motilin (MTL, 167.8 pg/ml), acetylcholinesterase (AChE, 45.3 pg/ml), substance P (SP, 61.0 pg/ml), vasoactive intestinal peptide (VIP, 70.5 pg/ml), endothelin‐1 (ET‐1, 16.1 pg/ml), and gastrin (73.0 pg/ml) and remarkably decreased somatostatin (SS, 35.2 pg/ml) when compared to those indexes in the LP‐KSFY06 group and geniposide group. The LP + G treatment also significantly increased the mRNA expression of cluster of differentiation 117 (c‐Kit), stem cell factor (SCF), glial cell‐derived neurotrophic factor (GDNF), and remarkably downregulated the expression of inducible nitric oxide synthase (iNOS), transient receptor potential vanilloid‐1 (TRPV1), and cyclooxygenase‐2 (COX‐2). The experimental results showed that the combination treatment has the strongest prevention effect against constipation, and LP‐KSFY06 promotes the ability of geniposide to prevent constipation. Therefore, LP‐KSFY06 is a potential probiotic strain with the capacity to prevent montmorillonite‐induced constipation., Combined effects of Lactobacillus plantarum KSFY06 and geniposide could inhibit the montmorillonite‐induced constipation in Kunming mice.
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- 2020
36. SetRank: Learning a Permutation-Invariant Ranking Model for Information Retrieval
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Yanyan Lan, Jun Xu, Qingyao Ai, Xueqi Cheng, Ji-Rong Wen, and Liang Pang
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FOS: Computer and information sciences ,Multivariate statistics ,Information retrieval ,Computer science ,Computer Science::Information Retrieval ,02 engineering and technology ,010501 environmental sciences ,01 natural sciences ,Computer Science - Information Retrieval ,Ranking ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,Learning to rank ,Invariant (mathematics) ,Information Retrieval (cs.IR) ,0105 earth and related environmental sciences - Abstract
In learning-to-rank for information retrieval, a ranking model is automatically learned from the data and then utilized to rank the sets of retrieved documents. Therefore, an ideal ranking model would be a mapping from a document set to a permutation on the set, and should satisfy two critical requirements: (1)~it should have the ability to model cross-document interactions so as to capture local context information in a query; (2)~it should be permutation-invariant, which means that any permutation of the inputted documents would not change the output ranking. Previous studies on learning-to-rank either design uni-variate scoring functions that score each document separately, and thus failed to model the cross-document interactions; or construct multivariate scoring functions that score documents sequentially, which inevitably sacrifice the permutation invariance requirement. In this paper, we propose a neural learning-to-rank model called SetRank which directly learns a permutation-invariant ranking model defined on document sets of any size. SetRank employs a stack of (induced) multi-head self attention blocks as its key component for learning the embeddings for all of the retrieved documents jointly. The self-attention mechanism not only helps SetRank to capture the local context information from cross-document interactions, but also to learn permutation-equivariant representations for the inputted documents, which therefore achieving a permutation-invariant ranking model. Experimental results on three large scale benchmarks showed that the SetRank significantly outperformed the baselines include the traditional learning-to-rank models and state-of-the-art Neural IR models., Accepted at SIGIR 2020
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- 2019
37. Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins
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Pilhan Kim, Yoon Yeo, Steve S. Lee, Wooin Lee, Ruo Yu Zhang, Jun Xu, Zhong Yin Zhang, Liang Pang, Stephen J. Kron, Howon Seo, and Yearin Jun
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Endothelium ,Polymers ,Quinic Acid ,Mice, Nude ,Antineoplastic Agents ,Mammary Neoplasms, Animal ,02 engineering and technology ,Pharmacology ,Umbilical vein ,Article ,Biomaterials ,03 medical and health sciences ,chemistry.chemical_compound ,Mice ,0302 clinical medicine ,Drug Delivery Systems ,Cell Line, Tumor ,medicine ,Human Umbilical Vein Endothelial Cells ,Tumor Microenvironment ,Animals ,Humans ,General Materials Science ,Tumor microenvironment ,Drug Carriers ,Microscopy, Confocal ,Endothelial Cells ,General Chemistry ,021001 nanoscience & nanotechnology ,Flow Cytometry ,PLGA ,medicine.anatomical_structure ,chemistry ,Paclitaxel ,030220 oncology & carcinogenesis ,Drug delivery ,Selectins ,Nanoparticles ,Female ,0210 nano-technology ,Drug carrier ,Selectin ,Biotechnology - Abstract
Current nanoparticle (NP) drug carriers mostly depend on the the enhanced permeability and retention (EPR) effect for selective drug delivery to solid tumors. However, in the absence of persistent EPR effect, the peritumoral endothelium can function as an access barrier to tumors and negatively affect the effectiveness of NPs. In recognition of the peritumoral endothelium as a potential barrier in drug delivery to tumors, poly(lactic-co-glycolic acid) NPs are modified with a quinic acid (QA) derivative, synthetic mimic of selectin ligands. QA-decorated NPs (QA-NP) interact with human umbilical vein endothelial cells (HUVECs) expressing E-/P-selectins and induce transient increase in endothelial permeability to translocate across the layer. QA-NP reach selectin-upregulated tumors, achieving greater tumor accumulation and paclitaxel (PTX) delivery than polyethylene glycol-decorated NPs (PEG-NP). PTX-loaded QA-NP show greater anti-cancer efficacy than Taxol® or PTX-loaded PEG-NP at the equivalent PTX dose in different animal models and dosing regimens. Repeated dosing of PTX-loaded QA-NP for two weeks result in complete tumor remission in 40-60% of MDA-MB-231 tumor-bearing mice, while those receiving control treatments succumb to death. QA-NP can exploit the interaction with selectin-expressing peritumoral endothelium and deliver anti-cancer drugs to tumors to a greater extent than the level currently possible with the EPR effect.
- Published
- 2018
38. Anticancer Effect of Ursodeoxycholic Acid in Human Oral Squamous Carcinoma HSC-3 Cells through the Caspases
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Xiaotong Tan, Lihua Qiu, Liang Pang, Weiwei Liu, Jiang Deng, and Xin Zhao
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Modern medicine ,caspase ,lcsh:TX341-641 ,Antineoplastic Agents ,Pharmacology ,Inhibitor of apoptosis ,digestive system ,Fas ligand ,Article ,Inhibitor of Apoptosis Proteins ,Cell Line, Tumor ,expression ,Medicine ,Humans ,RNA, Messenger ,human oral squamous carcinoma HSC-3 cells ,Nutrition and Dietetics ,Dose-Response Relationship, Drug ,business.industry ,Squamous Cell Carcinoma of Head and Neck ,Ursodeoxycholic Acid ,apoptosis ,NF-kappa B ,Ursodeoxycholic acid ,Squamous carcinoma ,XIAP ,Enzyme Activation ,Receptors, TNF-Related Apoptosis-Inducing Ligand ,Biochemistry ,Apoptosis ,Head and Neck Neoplasms ,Caspases ,Cancer cell ,Carcinoma, Squamous Cell ,business ,lcsh:Nutrition. Foods and food supply ,Food Science ,medicine.drug - Abstract
Bear bile was used as a traditional medicine or tonic in East Asia, and ursodeoxycholic acid (UDCA) is the most important compound in bear bile. Further, synthetic UDCA is also used in modern medicine and nutrition, therefore, its further functional effects warrant research, in vitro methods could be used for the fundamental research of its anticancer effects. In this study, the apoptotic effects of UDCA in human oral squamous carcinoma HSC-3 cells through the activation of caspases were observed by the experimental methods of MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide) assay, DAPI (4’,6-diamidino-2-phenylindole) staining, flow cytometry analysis, RT-PCR (reverse transcription-polymerase chain reaction) assay and Western blot assay after HSC-3 cells were treated by different concentrations of UDCA. With 0 to 400 μg/mL UDCA treatment, UDCA had strong growth inhibitory effects in HSC-3 cells, but had almost no effect in HOK normal oral cells. At concentrations of 100, 200 and 400 μg/mL, UDCA could induce apoptosis compared to untreated control HSC-3 cells. Treatment of 400 μg/mL UDCA could induce more apoptotic cancer cells than 100 and 200 μg/mL treatment, the sub-G1 DNA content of 400 μg/mL UDCA treated cancer cells was 41.3% versus 10.6% (100 μg/mL) and 22.4% (200 μg/mL). After different concentrations of UDCA treatment, the mRNA and protein expressions of caspase-3, caspase-8, caspase-9, Bax, Fas/FasL (Fas ligand), TRAIL (TNF-related apoptosis-inducing ligand), DR4 (death receptor 4) and DR5 (death receptor 5) were increased in HSC-3 cells, and mRNA and protein expressions of Bcl-2 (B-cell lymphoma 2), Bcl-xL (B-cell lymphoma-extra large), XIAP (X-linked inhibitor of apoptosis protein), cIAP-1 (cellular inhibitor of apoptosis 1), cIAP-2 (cellular inhibitor of apoptosis 2) and survival were decreased. Meanwhile, at the highest concentration of 400 μg/mL, caspase-3, caspase-8, caspase-9, Bax, Fas/FasL, TRAIL, DR4, DR5, and IκB-α expression levels were the highest, and Bcl-2, Bcl-xL, XIAP, cIAP-1, cIAP-2, survival, and NF-κB expression levels were the lowest. These results proved that UDCA could induce apoptosis of HSC-3 cancer cells through caspase activation, and the higher concentration of UDCA had stronger effects in vitro. UDCA might be a good nutrient for oral cancer prevention.
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- 2015
39. Magnesium boosts the memory restorative effect of environmental enrichment in Alzheimer's disease mice
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Ying Huang, Ke Liang Pang, Jian Ying Shen, Ling Zhang, Xue Li, Fang Han, and Xian Huang
- Subjects
0301 basic medicine ,Time Factors ,Mice, Transgenic ,Environment ,CREB ,Receptors, N-Methyl-D-Aspartate ,03 medical and health sciences ,Amyloid beta-Protein Precursor ,Mice ,0302 clinical medicine ,Alzheimer Disease ,Physiology (medical) ,Ca2+/calmodulin-dependent protein kinase ,Presenilin-1 ,Medicine ,Animals ,Humans ,Pharmacology (medical) ,Magnesium ,Receptor ,Maze Learning ,Pharmacology ,Environmental enrichment ,Memory Disorders ,biology ,business.industry ,Therapeutic effect ,Cognition ,Recognition, Psychology ,Original Articles ,CREB-Binding Protein ,Psychiatry and Mental health ,Disease Models, Animal ,030104 developmental biology ,Mutation ,Synapses ,biology.protein ,NMDA receptor ,Signal transduction ,business ,Calcium-Calmodulin-Dependent Protein Kinase Type 2 ,Neuroscience ,030217 neurology & neurosurgery ,Signal Transduction - Abstract
SummaryBackground Environmental enrichment (EE) has been shown to enhance cognitive function in mouse models of Alzheimer's disease (AD). Magnesium-L-threonate (MgT) is a compound with a newly discovered effect to rescue learning and memory function in aging and AD mice. Aim To study the additive therapeutic effect of EE combined with MgT (EM) and the potential mechanism underlying the effects. Materials and Methods APP/PS1 mice were treated with EE, MgT, or combination of EE and MgT (EM) and compared for restored memory function. Results EM was more effective in improving cognition and spatial memory than either treatment alone in either long-term (12 months, started at 3 months old, which was before disease manifestation) or short-term (3 months, started at 6 months old, which was after disease manifestation) treatment. The behavioral improvement has coincided with rescue of synaptic contacts in the hippocampal region of the AD mouse brain. Immunoblots also showed that EM but neither single treatment rescued the activity reduction in CaMKII and CREB, two important downstream molecules in the N-methyl-D-aspartate receptor (NMDAR) pathway. Conclusion Environmental enrichment and MgT may synergistically improve recognition and spatial memory by reducing synaptic loss and restoring the NMDAR signaling pathway in AD mice, which suggests that combination of EE and MgT may be a novel therapeutic strategy for AD.
- Published
- 2017
40. Localization of multiple jamming attackers in vehicular ad hoc network
- Author
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Xiao Chen, Rida Khatoun, Zhi Xue, Liang Pang, Yong Shi, Laboratoire Traitement et Communication de l'Information (LTCI), Institut Mines-Télécom [Paris] (IMT)-Télécom Paris, and HAL, TelecomParis
- Subjects
Computer Networks and Communications ,Computer science ,Wireless ad hoc network ,Jamming ,02 engineering and technology ,lcsh:QA75.5-76.95 ,[INFO.INFO-CR]Computer Science [cs]/Cryptography and Security [cs.CR] ,[INFO.INFO-MC]Computer Science [cs]/Mobile Computing ,[INFO.INFO-MC] Computer Science [cs]/Mobile Computing ,Control channel ,11. Sustainability ,0202 electrical engineering, electronic engineering, information engineering ,Wireless ,[INFO]Computer Science [cs] ,Network performance ,ComputingMilieux_MISCELLANEOUS ,Vehicular ad hoc network ,business.industry ,General Engineering ,Particle swarm optimization ,020206 networking & telecommunications ,Mobile ad hoc network ,020201 artificial intelligence & image processing ,lcsh:Electronic computers. Computer science ,business ,Computer network - Abstract
In vehicular ad hoc network, wireless jamming attacks are easy to be launched in the control channel and can cause serious influence on the network performance which may cause further safety accidents. In order to address the issue of wireless jamming attacks, a new technique which localizes the jamming attackers and prevents vehicles from jamming through human intervention is proposed. In this article, we propose a range-free approach to localize the source of the attacker and determine the number of jamming attackers. The data set is the locating information and the jamming detection information associated with each vehicle. Then, we formulate the problem of determining the number of attackers as a multiclass detection problem. We define the incorrectly classified area and use it to measure the distance between samples and centroids in fuzzy c-means algorithm. We further determine the number of jamming attackers through the coverage rate of beaconing circles and utilize weight-based fuzzy c-means to classify the data set. When the data set is classified as acceptable, we further explore the means of using particle swarm optimization algorithm to calculate the positional coordinates of each attacker. We simulate our techniques in MATLAB, and both urban traffic area and open area are considered in our simulation. The experimental results suggest that the proposed algorithm can achieve high precision when determining the number of attackers while the result of the classified performance is always satisfying. Our localization results lead to higher accuracy than other existing solutions. Also, when the data set is limited, the chances of taking accurate localization are higher than other measures.
- Published
- 2017
- Full Text
- View/download PDF
41. Effects of intravenous thrombolysis with alteplase combined with edaravone on cerebral hemodynamics and T lymphocyte level in patients with acute cerebral infarction.
- Author
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Xiu-Xiu Li, Shi-Hui Liu, Su-Jing Zhuang, Shi-Feng Guo, Shou-Liang Pang, Li, Xiu-Xiu, Liu, Shi-Hui, Zhuang, Su-Jing, Guo, Shi-Feng, and Pang, Shou-Liang
- Published
- 2020
- Full Text
- View/download PDF
42. Analysis of Extreme Wind Speed Estimates in the Northern South China Sea.
- Author
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ZHIDUO YAN, LIANG PANG, and SHENG DONG
- Subjects
- *
WIND speed , *OFFSHORE structures , *PARAMETER estimation , *TROPICAL cyclones , *MARINE resources conservation , *EXTREME value theory - Abstract
An increasing number of coastal and offshore structures have been built for coastal protection and marine development in recent years, and these marine structures need to be reasonably designed on the basis of wind speed. In this paper, extreme wind speed estimates are studied in detail by using the best-track datasets of northwestern Pacific Ocean tropical cyclones and ERA5 wind field data. The extreme wind speed fits by five distributions are compared using a blended sample of the wind fields from the ERA5 dataset and parametric wind data. The blend of wind fields improved the data accuracy and extreme value estimation reliability. In addition, the effects of the distribution model, data, threshold, and parameter estimation methods on the calculated results are discussed. The results show that the data had the greatest influences on probability prediction, followed by the distribution model and the parameter estimation method, with the threshold presenting the least influence. In this study, the reliability of the estimates was improved and the uncertainty of the results was analyzed, and the findings provide a wind speed design reference for the northern South China Sea. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
43. The Calculation of Extreme Wind Speed Based on Bayesian Method.
- Author
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Jianchun Zhao, Zhiduo Yan, Xiaofeng Chen, Liang Pang, and Yanyan Lu
- Subjects
WIND speed ,TYPHOONS ,CONDITIONAL expectations ,MARKOV chain Monte Carlo ,MAXIMUM likelihood statistics ,OFFSHORE structures ,RANDOM variables - Abstract
Wind speed is one of the main factors to be considered in the design of offshore structures. However, due to the long period fluctuation of typhoons and climate change, the return levels of the wind speed derived using the samples of different years are considerably different, which can lead to unstable results. To solve this problem, in this study, the extreme wind speed is calculated based on the Bayesian method. In the Bayesian parameter estimation method, the parameters of the distribution are considered as random variables, and thus, the priori information can be fully exploited for parameter estimations. The data utilized in this study are deriveds from the best data set of the northwest Pacific tropical cyclone. A typical point in the South China Sea is selected as the calculation point. The samples are determined are determined using a parametric wind model developed by Cardone. Considering the influence of the difference samples of in different time instants, the samples are divided into early and recent samples, which are used as priori and posteriori information, respectively. The normal distribution is used as the priori distribution, and the estimator of the parameters is the expectation of the posteriori distribution, which is calculated using the Markov Chain Monte Carlo (MCMC) algorithm. By comparing the results pertaining to between Bayesian and maximum likelihood method, it can be observed that the former is more stable and reliable. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
44. TYMER: A Yield-based Performance Model for Timing-speculation SRAM.
- Author
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Shan Shen, Liang Pang, Tianxiang Shao, Ming Ling, Xiao Shi, and Longxing Shi
- Subjects
LOW voltage systems ,ENERGY consumption ,COMPUTER simulation ,MICROFABRICATION ,ERROR correction (Information theory) - Abstract
In low power designs, timing-speculative techniques are proposed to boost the SRAM frequency and throughput. This paper proposes TYMER, a unified yield-based performance model for timing-speculative SRAM. In TYMER, the first submodel evaluates access-time yield at different worldline enable time for a general 6T SRAM under low supply voltages, while the second one uses the yield results to estimate optimal sensing time and the overall read latency for speculative SRAM. TYMER is not only compared with simulation results but also the measurements from 28nm fabricated speculative SRAM chips. Both cases show precise evaluation results under different operating conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2020
45. Purple bamboo salt has anticancer activity in TCA8113 cells in vitro and preventive effects on buccal mucosa cancer in mice in vivo
- Author
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Lihua Qiu, Kun-Young Park, Xiaoxiao Deng, Xin Zhao, and Liang Pang
- Subjects
Cancer Research ,Pathology ,medicine.medical_specialty ,food.ingredient ,Institute of Cancer Research mice ,U14 squamous cell carcinoma cells ,Biology ,chemistry.chemical_compound ,food ,Immunology and Microbiology (miscellaneous) ,In vivo ,medicine ,metastasis ,DAPI ,purple bamboo salt ,Sea salt ,Cancer ,General Medicine ,Articles ,buccal mucosa cancer ,medicine.disease ,Molecular biology ,In vitro ,Staining ,chemistry ,Apoptosis ,Cancer cell - Abstract
Bamboo salt is a traditional healthy salt known in Korea. The in vitro anticancer effects of the salt were evaluated using a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) assay in TCA8113 human tongue carcinoma cells. At 1% concentration, the growth inhibitory rate of purple bamboo salt was 61% higher than that of sea salt (27%). Apoptosis analysis of the cancer cells was carried out using 4,6-diamidino-2-phenylindole (DAPI) staining to investigate the mechanism of the anticancer effects in tongue carcinoma cells. Purple bamboo salt induced a stronger apoptotic effect than sea salt. An Institute of Cancer Research (ICR) mouse buccal mucosa cancer model was established by injecting mice with U14 squamous cell carcinoma cells. Following injection, the wound at the injection site was smeared with salt samples. It was observed that the tumor volumes for the group treated with purple bamboo salt were smaller than those from the sea salt treatment and control groups. The sections of buccal mucosa cancer tissue showed that canceration in the purple bamboo salt group was weaker compared with that in the sea salt group. Similar results were observed in the lesion section of the cervical lymph. Using reverse transcription-polymerase chain reaction (RT-PCR) and western blotting, the purple bamboo salt group demonstrated an increase in Bcl-2-associated X protein (Bax) and a decrease in B cell lymphoma-2 (Bcl-2), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression, compared with the sea salt and control groups. The results demonstrated that purple bamboo salt had improved in vivo buccal mucosa cancer preventive activity compared with sea salt in mice.
- Published
- 2012
46. Generation of an equilibrium collection of crystalline solids from a dynamic combinatorial library
- Author
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Ke-liang Pang, Dong Guo, Chun-Ying Duan, Hong Mo, and Qing-jin Meng
- Subjects
Solvents -- Composition ,Copper ,Alcohol, Denatured ,Alcohol ,Methanol ,Solids -- Composition ,Inorganic compounds -- Composition ,Chemistry, Inorganic -- Research ,Chemistry - Abstract
Research has been conducted on copper-contained building block. The authors have demonstrated that the thermodynamically controlled crystallization of these blocks carried out from methanol-ethanol mixture solvent produces a combinatorial mixture of crystalline solids.
- Published
- 2003
47. Temporal changes in soil bacterial and archaeal communities with different fertilizers in tea orchards* #
- Author
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Shao-hui Yang, Hua Wang, Ji-liang Pang, Ya-min Lv, Xing Zhao, and Jing-ping Yang
- Subjects
General Veterinary ,biology ,Bacteria ,Tea ,Microbial Consortia ,Temperature ,General Medicine ,Soil carbon ,biology.organism_classification ,Archaea ,General Biochemistry, Genetics and Molecular Biology ,Denitrifying bacteria ,Terminal restriction fragment length polymorphism ,Soil pH ,Botany ,Seasons ,General Pharmacology, Toxicology and Pharmaceutics ,Fertilizers ,Relative species abundance ,Organic fertilizer ,Soil microbiology ,Soil Microbiology ,Biotechnology - Abstract
It is important to understand the effects of temporal changes in microbial communities in the acidic soils of tea orchards with different fertilizers. A field experiment involving organic fertilizer (OF), chemical fertilizer (CF), and unfertilized control (CK) treatments was arranged to analyze the temporal changes in the bacterial and archaeal communities at bimonthly intervals based on the 16S ribosomal RNA (rRNA) gene using terminal restriction fragment length polymorphism (T-RFLP) profiling. The abundances of total bacteria, total archaea, and selected functional genes (bacterial and archaeal amoA, bacterial narG, nirK, nirS, and nosZ) were determined by quantitative polymerase chain reaction (qPCR). The results indicate that the structures of bacterial and archaeal communities varied significantly with time and fertilization based on changes in the relative abundance of dominant T-RFs. The abundancy of the detected genes changed with time. The total bacteria, total archaea, and archaeal amoA were less abundant in July. The bacterial amoA and denitrifying genes were less abundant in September, except the nirK gene. The OF treatment increased the abundance of the observed genes, while the CF treatment had little influence on them. The soil temperature significantly affected the bacterial and archaeal community structures. The soil moisture was significantly correlated with the abundance of denitrifying genes. Of the soil chemical properties, soil organic carbon was the most important factor and was significantly correlated with the abundance of the detected genes, except the nirK gene. Overall, this study demonstrated the effects of both temporal alteration and organic fertilizer on the structures of microbial communities and the abundance of genes involved in the nitrogen cycle.
- Published
- 2014
48. Probability analysis of storm surge intensity and magnitude in China.
- Author
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Sheng, Dong, Liang, Pang, and Kai, Wang
- Published
- 2016
- Full Text
- View/download PDF
49. [3 + 2] Cycloaddition of Oxazol-5-(4H)-ones with Nitrones for Diastereoselective Synthesis of Isoxazolidin-5-ones.
- Author
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Hong-Wu Zhao, Yue-Yang Liu, Yu-Di Zhao, Hai-Liang Pang, Xiao-Qin Chen, Xiu-Qing Song, Ting Tian, Bo Li, Zhao Yang, Juan Du, and Ning-Ning Feng
- Published
- 2017
- Full Text
- View/download PDF
50. Diastereoselective 1,3-Dipolar Cycloadditions of N,N'-Cyclic Azomethine Imines with Iminooxindoles for Access to Oxindole Spiro-N,N-bicyclic Heterocycles.
- Author
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Hong-Wu Zhao, Bo Li, Hai-Liang Pang, Ting Tian, Xiao-Qin Chen, Xiu-Qing Song, Wei Meng, Zhao Yang, Yu-Di Zhao, and Yue-Yang Liu
- Published
- 2016
- Full Text
- View/download PDF
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