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346 results on '"Li, Si-Yu"'

28. Single-Cell Transcriptomics Reveals Early Effects of Ionizing Radiation on Bone Marrow Mononuclear Cells in Mice.

Author

Wu, Yun-Qiang, Ding, Ke-Xin, Lv, Zhi-Chun, Cao, Zheng-Yue, Zhao, Ke, Gao, Hui-Ying, Sun, Hui-Ying, Li, Jing-Jing, Li, Si-Yu, Zhao, Xiong-Wei, Xue, Yang, Xiang, Shen-Si, Zheng, Xiao-Fei, Yang, Xiao-Ming, and Li, Chang-Yan

Subjects
BONE marrow cells, PROGENITOR cells, CELL populations, HEMATOPOIETIC system, IONIZING radiation, B cells
Abstract

Ionizing radiation exposure can cause damage to diverse tissues and organs, with the hematopoietic system being the most sensitive. However, limited information is available regarding the radiosensitivity of various hematopoietic cell populations in the bone marrow due to the high heterogeneity of the hematopoietic system. In this study, we observed that granulocyte–macrophage progenitors, hematopoietic stem/progenitor cells, and B cells within the bone marrow showed the highest sensitivity, exhibiting a rapid decrease in cell numbers following irradiation. Nonetheless, neutrophils, natural killer (NK) cells, T cells, and dendritic cells demonstrated a certain degree of radioresistance, with neutrophils exhibiting the most pronounced resistance. By employing single-cell transcriptome sequencing, we investigated the early responsive genes in various cell types following irradiation, revealing that distinct gene expression profiles emerged between radiosensitive and radioresistant cells. In B cells, radiation exposure led to a specific upregulation of genes associated with mitochondrial respiratory chain complexes, suggesting a connection between these complexes and cell radiosensitivity. In neutrophils, radiation exposure resulted in fewer gene alterations, indicating their potential for distinct mechanisms in radiation resistance. Collectively, this study provides insights into the molecular mechanism for the heterogeneity of radiosensitivity among the various bone marrow hematopoietic cell populations. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Nonlinear Optical Response Modulated by Lattice Reconstruction in Small‐Angle Twisted Bilayer MoS2.

Author

Xu, Chang, Mao, Yu, Li, Kaihui, Wang, Zixin, Liu, Xueying, Dong, Ningning, Li, Si‐Yu, Pan, Anlian, and Wang, Jun

Subjects
SCANNING tunneling microscopy, BILAYER lipid membranes
Abstract

Subtle perturbations in interlayer twist angles offer a novel investigational avenue for revealing intriguing optical characteristics within the domain of 2D materials. In this study, a homogeneous bilayer structure featuring precisely defined interlayer twist angles is meticulously engineered by stacking monolayer single‐crystal MoS2 in a controlled, layer‐by‐layer manner. Scanning tunneling microscopy (STM) reveals an unexpected lattice reconstruction, particularly at twist angles of ≤ 2°, which induces the emergence of expansive rhombohedral‐stacked large triangular domains. Furthermore, a second‐harmonic generation (SHG) is utilized as a sensitive modality to demonstrate profound transformations in the local electron band structures. By combining the linear spectra with SHG, the change in the C‐exciton optical response in the band‐nesting region of the small‐angle twisted bilayer MoS2 before and after crossing a critical twist angle of 2° is discussed. The study shows that SHG can be used as a nondestructive method to characterize the lattice structure of small‐angle twisted bilayer samples. Furthermore, determining the potential relationship between the lattice reconstruction and the linear and nonlinear spectra further demonstrates the regulatory effect of the interlayer twist angle on the nonlinear optical effects of 2D materials. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Flight order does not influence individuals' flight initiation distance in small bird flocks.

Author

Zhao, Jin-Ming, Liu, Hong-Chuang, Li, Si-Yu, Ding, Yi-Hang, Wang, Jun-Jie, and Zhang, Yan

Subjects
FLIGHT, RESEARCH personnel
Abstract

Researchers often measure the flight initiation distance (FID) of a selected individual to represent the FID of the whole groups which may vary with their flight order (the sequence to flee) and their spatial position within a group. In this study, we examined FID of all individuals in small bird flocks in urban environments when approached by an investigator. We found that individuals' FID did not vary with their flight orders within these flocks. Moreover, the FID of the nearest individual, often used as a proxy for the entire flock, did not differ from the average FID of all flock members. This suggests that the conventional method of measuring the nearest individual's FID to represent is a valid approximation for representing the behaviour of the entire flock in similar contexts. These results have important implications for understanding anti-predator strategies in group-living animals and can inform future studies in this field. [ABSTRACT FROM AUTHOR]

Published
2024
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