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1. Prognostic implications of CD9 in childhood acute lymphoblastic leukemia: insights from a nationwide multicenter study in China

Author

Leung, Kam Tong, Cai, Jiaoyang, Liu, Yu, Chan, Kathy Yuen Yee, Shao, Jingbo, Yang, Hui, Hu, Qun, Xue, Yao, Wu, Xuedong, Guo, Xia, Zhai, Xiaowen, Wang, Ningling, Li, Xue, Tian, Xin, Li, Zheng, Xue, Ning, Guo, Yuxia, Wang, Lingzhen, Zou, Yao, Xiao, Peifang, He, Yingyi, Jin, Runming, Tang, Jingyan, Yang, Jun J., Shen, Shuhong, Pui, Ching-Hon, and Li, Chi Kong

Published
2024
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4. Prevalence of anemia at diagnosis of pediatric chronic myeloid leukemia and prognostic impact on the disease course

Author

Delehaye, Fanny, Rouger, Jérémie, Brossier, David, Suttorp, Meinolf, Güneş, Adalet Meral, Sedlacek, Petr, Versluys, Birgitta, Li, Chi Kong, Kalwak, Krzysztof, Lausen, Birgitte, Srdjana, Culic, Dworzak, Michael, Hraskova, Andrea, De Moerloose, Barbara, Roula, Farah, Briant, Anaïs, Parienti, Jean-Jacques, and Millot, Frédéric

Published
2023
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6. Effect of the tyrosine kinase inhibitors on the growth in children with Philadelphia chromosome–positive acute lymphoblastic leukemia: a case–control study

Author

Cai, Jiaoyang, Liu, Hu, Chen, Yumei, Yu, Jie, Gao, Ju, Jiang, Hua, Zhai, Xiaowen, Ju, Xiuli, Wu, Xuedong, Wang, Ningling, Tian, Xin, Liang, Changda, Fang, Yongjun, Zhou, Fen, Li, Hong, Sun, Lirong, Yang, Liangchun, Guo, Jing, Liu, Aiguo, Li, Chi-kong, Zhu, Yiping, Tang, Jingyan, Yang, Jun J., Shen, Shuhong, Cheng, Cheng, and Pui, Ching-Hon

Published
2023
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11. Prognosis of pediatric BCP‐ALL with IKZF1 deletions and impact of intensive chemotherapy: Results of SCCLG‐2016 study.

Author

Lin, Shaofen, Liao, Ning, Li, Xinyu, Yang, Lihua, He, Yun‐yan, Tang, Yan‐Lai, Wan, Wu‐Qing, Jia, Wenguang, Zhang, Ya‐jie, Kong, Qian, Long, Xingjiang, Lan, Xiang, Ling, Ya‐yun, Lin, Danna, Zhang, Xiao‐li, Wen, Chuan, Li, Chi‐kong, and Xu, Hong‐gui

Abstract

Background: IKZF1 deletion (IKZF1del) is associated with poor prognosis in B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL). But the prognosis of IKZF1del combined with other prognostic stratification factors remains unclear. Whether intensified treatment improves BCP‐ALL prognosis has not been determined. Method s : A retrospective analysis was performed on 1291 pediatric patients diagnosed with BCP‐ALL and treated with the South China Children's Leukemia 2016 protocol. Patients were stratified based on IKZF1 status for comparison of characteristics and outcome. Additionally, IKZF1del patients were further divided based on chemotherapy intensity for outcome assessments. Results: The BCP‐ALL pediatric patients with IKZF1del in south China showed poorer early response. Notably, the DFS and OS for IKZF1del patients were markedly lower than IKZF1wt group (3‐year DFS: 88.7% [95% CI: 83.4%–94.0%] vs. 93.5% [95% CI: 92.0%–94.9%], P =.021; 3‐year OS: 90.7% [95% CI: 85.8% to 95.6%] vs. 96.1% [95% CI: 95% to 97.2%, P =.003]), with a concurrent increase in 3‐year TRM (6.4% [95% CI: 2.3%–10.5%] vs. 2.9% [95% CI: 1.9%–3.8%], P =.025). However, the 3‐year CIR was comparable between the two groups (5.7% [95% CI: 1.8%–9.5%] vs. 3.7% [95% CI: 2.6%–4.7%], P =.138). Subgroup analyses reveal no factor significantly influenced the prognosis of the IKZF1del cohort. Noteworthy, intensive chemotherapy improved DFS from 85.7% ± 4.1% to 94.1% ± 0.7% in IKZF1del group (P =.084). Particularly in BCR::ABL positive subgroup, the 3‐year DFS was remarkably improved from 53.6% ± 20.1% with non‐intensive chemotherapy to 100% with intensive chemotherapy (P =.026). Conclusions: Pediatric BCP‐ALL patients with IKZF1del in South China manifest poor outcomes without independent prognostic significance. While no factor substantially alters the prognosis in the IKZF1del group. Intensified chemotherapy may reduce relapse rates and improve DFS in patients with IKZF1del subset, particularly in IKZFdel patients with BCR::ABL positive. [ABSTRACT FROM AUTHOR]

Published
2024
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12. R4 RGS proteins suppress engraftment of human hematopoietic stem/progenitor cells by modulating SDF-1/CXCR4 signaling

Author

Chan, Kathy Yuen Yee, Zhang, Chi, Wong, Yorky Tsin Sik, Zhang, Xiao-Bing, Wang, Chi Chiu, Ng, Wing Hei, Fok, Siu Ping, Tang, Patrick Ming Kuen, Kang, Wei, Feng, Bo, Poon, Ellen Ngar Yun, Lee, King Yiu, Lee, Cheuk Kwong, Chen, Chun, Leung, Tak Yeung, Ng, Margaret Heung Ling, To, Ka Fai, Wang, Han, Lam, Hugh Simon, Ng, Pak Cheung, Yuen, Patrick Man Pan, Li, Karen, Leung, Alex Wing Kwan, Li, Chi Kong, and Leung, Kam Tong

Published
2021
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13. Pulse therapy with vincristine and dexamethasone for childhood acute lymphoblastic leukaemia (CCCG-ALL-2015): an open-label, multicentre, randomised, phase 3, non-inferiority trial

Author

Yang, Wenyu, Cai, Jiaoyang, Shen, Shuhong, Gao, Ju, Yu, Jie, Hu, Shaoyan, Jiang, Hua, Fang, Yongjun, Liang, Changda, Ju, Xiuli, Wu, Xuedong, Zhai, Xiaowen, Tian, Xin, Wang, Ningling, Liu, Aiguo, Jiang, Hui, Jin, Runming, Sun, Lirong, Yang, Minghua, Leung, Alex W K, Pan, Kaili, Zhang, Yingchi, Chen, Jing, Zhu, Yiping, Zhang, Hui, Li, Chunfu, Yang, Jun J, Cheng, Cheng, Li, Chi-Kong, Tang, Jingyan, Zhu, Xiaofan, and Pui, Ching-Hon

Published
2021
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14. Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity

Author

Suiter, Chase C., Moriyama, Takaya, Matreyek, Kenneth A., Yang, Wentao, Scaletti, Emma Rose, Nishii, Rina, Yang, Wenjian, Hoshitsuki, Keito, Singh, Minu, Trehan, Amita, Parish, Chris, Smith, Colton, Li, Lie, Bhojwani, Deepa, Yuen, Liz Y. P., Li, Chi-kong, Li, Chak-ho, Yang, Yung-li, Walker, Gareth J., Goodhand, James R., Kennedy, Nicholas A., Klussmann, Federico Antillon, Bhatia, Smita, Relling, Mary V., Kato, Motohiro, Hori, Hiroki, Bhatia, Prateek, Ahmad, Tariq, Yeoh, Allen E. J., Stenmark, Pål, Fowler, Douglas M., and Yang, Jun J.

Published
2020

15. Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study

Author

Boer, Judith M., Valsecchi, Maria Grazia, Hormann, Femke M., Antić, Željko, Zaliova, Marketa, Schwab, Claire, Cazzaniga, Giovanni, Arfeuille, Chloé, Cavé, Hélène, Attarbaschi, Andishe, Strehl, Sabine, Escherich, Gabriele, Imamura, Toshihiko, Ohki, Kentaro, Grüber, Tanja A., Sutton, Rosemary, Pastorczak, Agata, Lammens, Tim, Lambert, Frédéric, Li, Chi Kong, Carrillo de Santa Pau, Enrique, Hoffmann, Steve, Möricke, Anja, Harrison, Christine J., Den Boer, Monique L., De Lorenzo, Paola, Stam, Ronald W., Bergmann, Anke K., and Pieters, Rob

Published
2021
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17. Association between cognitive impairment and functional limitations in everyday life in patients with haemophilia in Hong Kong.

Author

Cheung, Yin Ting, Ma, Chung Tin, Weishang, Deng, Lam, Henry Hon Wai, Ling, Siu Cheung, Kwok, Kevin, Li, Chak Ho, Ha, Chung Yin, Yip, Sze Fai, Siu Ming Wong, Raymond, Chu, Winnie Chiu Wing, and Li, Chi Kong

Subjects
HEMOPHILIACS, FUNCTIONAL status, CONTINUOUS performance test, COGNITION disorders
Abstract

This article explores the relationship between cognitive impairment and functional limitations in individuals with haemophilia in Hong Kong. The study reveals that patients who experience difficulties with memory, attention, and executive functioning tend to have poorer performance at work or school. These cognitive functions are crucial for setting and achieving goals, as well as adapting to one's surroundings, so deficiencies in these areas can impact occupational or educational performance. The findings suggest that regular monitoring of cognitive function should be integrated into the standard care for haemophilia patients, particularly those facing occupational or vocational challenges. Further research is necessary to develop a cost-effective and clinically feasible method for monitoring cognitive function in these individuals. The study investigates how cognitive impairment affects functional limitations in haemophilia patients. The researchers discover that impairments in attention, motor processing speed, and cognitive flexibility are linked to a decline in functional status. The study proposes that regular screening for cognitive deficits and cognitive rehabilitation may be necessary for this population. However, the study has limitations, such as potential selection bias and the absence of a control group. Further research is needed to validate the findings and assess the long-term consequences of functional limitations in haemophilia patients. [Extracted from the article]

Published
2024
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18. HLA alleles associated with asparaginase hypersensitivity in Chinese children

Author

Chua, Gilbert T., Rosa Duque, Jaime S., Cheuk, Daniel Ka Leung, Leung, Alex Wing Kwan, Wong, Wilfred Hing Sang, Liu, Anthony Pak Yin, Lee, Pamela P. W., Ha, Shau Yin, Chiang, Alan Kwok Shing, Ho, Marco Hok Kung, Chu, Wai Keung, Chan, Yuk Sing, Luk, Chun Wing, Ling, Alvin Siu Cheung, Kwan, Mike Yat Wah, Yiu, Oscar Kuen Fong, Wong, Ian Chi Kei, Lau, Yu Lung, Li, Chi Kong, Leung, Wing Hang, Chan, Godfrey Chi Fung, Ip, Patrick, and Kwok, Janette

Published
2021
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23. CD9 blockade suppresses disease progression of high-risk pediatric B-cell precursor acute lymphoblastic leukemia and enhances chemosensitivity

Author

Leung, Kam Tong, Zhang, Chi, Chan, Kathy Yuen Yee, Li, Karen, Cheung, John Tak Kit, Ng, Margaret Heung Ling, Zhang, Xiao-Bing, Sit, Tony, Lee, Wayne Yuk Wai, Kang, Wei, To, Ka Fai, Yu, Jasmine Wai Sum, Man, Toni Ki Fong, Wang, Han, Tsang, Kam Sze, Cheng, Frankie Wai Tsoi, Lam, Grace Kee See, Chow, Tin Wai, Leung, Alex Wing Kwan, Leung, Ting Fan, Yuen, Patrick Man Pan, Ng, Pak Cheung, and Li, Chi Kong

Published
2020
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25. Imatinib treatment of paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (EsPhALL2010): a prospective, intergroup, open-label, single-arm clinical trial

Author

Biondi, Andrea, Gandemer, Virginie, De Lorenzo, Paola, Cario, Gunnar, Campbell, Myriam, Castor, Anders, Pieters, Rob, Baruchel, André, Vora, Ajay, Leoni, Veronica, Stary, Jan, Escherich, Gabriele, Li, Chi-Kong, Cazzaniga, Giovanni, Cavé, Hélène, Bradtke, Jutta, Conter, Valentino, Saha, Vaskar, Schrappe, Martin, and Grazia Valsecchi, Maria

Published
2018
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30. Risk Factors for Subsequent Central Nervous System Tumors in Pediatric Allogeneic Hematopoietic Cell Transplant: A Study from the Center for International Blood and Marrow Transplant Research (CIBMTR)

Author

Gabriel, Melissa, Shaw, Bronwen E., Brazauskas, Ruta, Chen, Min, Margolis, David A., Sengelov, Henrik, Dahlberg, Ann, Ahmed, Ibrahim A., Delgado, David, Lazarus, Hillard M., Gibson, Brenda, Myers, Kasiani C., Kamble, Rammurti T., Abdel-Mageed, Aly, Li, Chi-Kong, Flowers, Mary E.D., Battiwalla, Minoo, Savani, Bipin N., Majhail, Navneet, and Shaw, Peter J.

Published
2017
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34. Clinical, neuroimaging, and behavioural risk factors for neurocognitive impairment in Chinese patients with haemophilia: A multicentre study.

Author

Cheung, Yin Ting, Ma, Chung Tin, Lam, Henry Hon Wai, Ling, Siu Cheung, Kwok, Kevin, Li, Chak Ho, Ha, Chung Yin, Yip, Sze Fai, Wong, Raymond Siu Ming, Chu, Winnie Chiu Wing, and Li, Chi Kong

Subjects
HEMOPHILIACS, COGNITIVE processing speed, CHINESE people, CRITICAL thinking, COGNITIVE flexibility
Abstract

Background: Few studies have evaluated the impact of subclinical microstructural changes and psychosocial factors on cognitive function in patients with haemophilia. Objectives: To determine the prevalence and characteristics of cognitive impairment in patients with haemophilia, and identify associated risk factors. Methods: We recruited haemophilia A or B patients who were aged ≥10 years old from three public hospitals in Hong Kong. A neurocognitive battery was administered to evaluate their attention, memory, processing speed and cognitive flexibility performances. They also underwent magnetic resonance imaging to identify cerebral microbleeds. Validated self‐reported questionnaires were administered to assess their mental health status and adherence to prophylactic treatment. General linear modelling was used to investigate the association of neurocognitive outcomes with risks factors, adjusting for age and education attainment. Results: Forty‐two patients were recruited (median age 32.0 years; 78.6% haemophilia A; 80.9% moderate‐to‐severe disease). Six patients (14.3%) had developed cerebral microbleeds. A subgroup of patients demonstrated impairments in cognitive flexibility (30.9%) and motor processing speed (26.2%). Hemarthrosis in the previous year was associated with worse attention (Estimate = 7.62, 95% CI: 1.92–15.33; p =.049) and cognitive flexibility (Estimate = 8.64, 95% CI: 2.52–13.29; p =.043). Depressive (Estimate = 0.22, 95% CI: 0.10–0.55; p =.023) and anxiety (Estimate = 0.26, 95% CI: 0.19–0.41; p =.0069) symptoms were associated with inattentiveness. Among patients receiving prophylactic treatment (71.4%), medication adherence was positively correlated with cognitive flexibility (p =.037). Conclusion: A substantial proportion of patients with haemophilia demonstrated cognitive impairment, particularly higher‐order thinking skills. Screening for cognitive deficits should be incorporated into routine care. Future studies should evaluate the association of neurocognitive outcomes with occupational/vocational outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Outcome of patients with hemoglobinopathies given either cord blood or bone marrow transplantation from an HLA-identical sibling

Author

Locatelli, Franco, Kabbara, Nabil, Ruggeri, Annalisa, Ghavamzadeh, Ardeshir, Roberts, Irene, Li, Chi Kong, Bernaudin, Françoise, Vermylen, Christiane, Dalle, Jean-Hugues, Stein, Jerry, Wynn, Robert, Cordonnier, Catherine, Pinto, Fernando, Angelucci, Emanuele, Socié, Gérard, Gluckman, Eliane, Walters, Mark C., and Rocha, Vanderson

Published
2013
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40. Additional cytogenetic abnormalities and variant t(9;22) at the diagnosis of childhood chronic myeloid leukemia: The experience of the International Registry for Chronic Myeloid Leukemia in Children and Adolescents

Author

Millot, Frédéric, Dupraz, Christelle, Guilhot, Joelle, Suttorp, Meinolf, Brizard, Françoise, Leblanc, Thierry, Güneş, Adalet Meral, Sedlacek, Petr, De Bont, Evelyne, Li, Chi Kong, Kalwak, Krzysztof, Lausen, Birgitte, Culic, Srdjana, Dworzak, Michael, Kaiserova, Emilia, De Moerloose, Barbara, Roula, Farah, Biondi, Andrea, Baruchel, André, and Guilhot, François

Published
2017
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42. The incidence, risk factors, and outcomes of symptomatic avascular necrosis of bone among Chinese pediatric patients with acute lymphoblastic leukemia.

Author

Hoo, Calvin Pui Lun, Leung, Alex Wing Kwan, Chan, Joyce Pui Kwan, Cheung, Yin Ting, Cheng, Frankie Wai Tsoi, Chow, Terry Tin Wai, Lam, Grace Kee See, Ha, Sau Yin, Chiang, Alan Kwok Shing, Li, Rever Chak Ho, and Li, Chi Kong

Subjects
CHILD patients, LYMPHOBLASTIC leukemia, OSTEONECROSIS, CHINESE people, ACUTE leukemia, IDIOPATHIC femoral necrosis
Abstract

Background: Avascular necrosis (AVN) of bone is a debilitating complication of pediatric patients with acute lymphoblastic leukemia (ALL). While it is extensively studied and reported in Western population, studies focused on Orientals are limited. This study aims to evaluate the incidence, risk factors, and clinical outcomes of AVN among Chinese children with ALL. Methods: This study is a retrospective, territory‐wide population‐based cohort study of pediatric patients with ALL enrolled on one of the three consecutive ALL study protocols (ALL‐IC‐BFM 2002, CCLG‐ALL 2008, and CCCG‐ALL 2015). Results: A total of 24 out of 533 pediatric subjects with ALL (4.5%) had symptomatic AVN. Age was the single most important risk factor associated with the development of AVN. Only three patients were below age of 10 at the time of diagnosis of ALL. The incidences of AVN in patients aged above and below 10 years were 18.2% ± 3.6% and 0.8% ± 0.5%, respectively, and were significantly different (p < 0.005). Treatment protocol, immunophenotype, and gender were not predictive of AVN. Among the 24 patients, five required orthopedic interventions in view of progressive and severe disease. For subjects with hip joints involvement, follow‐up assessments showed 12 of 22 hip joints had radiological progression over a median duration of 3.63 years. Seventeen of them did not have pain at the latest follow‐up and among patients with pain (n = 7), five did not experience any limitation on activities of daily living while two required use of walking aids or wheelchair. Conclusion: The incidence of symptomatic AVN in Chinese ALL patients was comparable to other studies in Western population. Adolescent age more than 10 years old was recognized to be the most important factor for development of AVN. Significant proportion of patients had radiological progression over time with a small percentage of subjects had daily activities affected. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study

Author

Biondi, Andrea, Schrappe, Martin, De Lorenzo, Paola, Castor, Anders, Lucchini, Giovanna, Gandemer, Virginie, Pieters, Rob, Stary, Jan, Escherich, Gabriele, Campbell, Myriam, Li, Chi-Kong, Vora, Ajay, Aricò, Maurizio, Röttgers, Silja, Saha, Vaskar, and Valsecchi, Maria Grazia

Published
2012
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44. A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression

Author

Farrell, John J., Sherva, Richard M., Chen, Zhi-yi, Luo, Hong-yuan, Chu, Benjamin F., Ha, Shau Yin, Li, Chi Kong, Lee, Anselm C.W., Li, Rever C.H., Li, Chi Keung, Yuen, Hui Leung, So, Jason C.C., Ma, Edmond S.K., Chan, Li Chong, Chan, Vivian, Sebastiani, Paola, Farrer, Lindsay A., Baldwin, Clinton T., Steinberg, Martin H., and Chui, David H.K.

Published
2011
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49. Associations between Lifestyle Factors and Neurocognitive Impairment among Chinese Adolescent and Young Adult (AYA) Survivors of Sarcoma.

Author

Cheung, Yin Ting, Ma, Chung Tin, Li, Michael Can Heng, Zhou, Keary Rui, Loong, Herbert Ho Fung, Chan, Agnes Sui Yin, Wong, Kwok Chuen, and Li, Chi Kong

Subjects
COGNITION disorders, SEDENTARY lifestyles, CANCER patient psychology, EVALUATION of medical care, MEMORY, COGNITIVE flexibility, OSTEOSARCOMA, COGNITIVE processing speed, SOFT tissue tumors, CANCER patients, COMPARATIVE studies, ATTENTION, DESCRIPTIVE statistics, SURVIVAL analysis (Biometry), EXERCISE, HEALTH behavior, RESEARCH funding, SMOKING, ADULTS, ADOLESCENCE
Abstract

Simple Summary: Young survivors of bone tumors and soft-tissue sarcoma are at risk of cognitive impairment due to their previous cancer therapies and the development of cancer-/treatment-related chronic health conditions as they age. We postulate that a compromised health status, coupled with the continued engagement in an unhealthy lifestyle during survivorship, may further exacerbate cognitive impairment among survivors. Our study found that survivors of bone tumors and soft-tissue sarcoma demonstrated impairment in attention, processing speed and executive function (higher order thinking ability). Low physical activity and smoking were associated with inattention. Survivors who worked >9 h per day had worse executive function than those with shorter working hours. Of note is that survivors who had a chronic health condition and were physically inactive demonstrated the worst attention and executive function performance. Our findings support continual efforts to investigate intervention targets and leverage health behaviors as modifiable risk factors to prevent cognitive dysfunction in this population. Background: The effect of lifestyle on neurocognitive impairment among cancer survivors remain an understudied area. This study explored the association between lifestyle factors and neurocognitive outcomes (specifically, attention, memory, processing speed and cognitive flexibility) in AYA survivors (aged 15–39 years) of sarcoma. Methods: This study recruited 116 AYA survivors (age 28.2 (SD = 8.2) years), who were diagnosed with osteosarcoma (49%) or soft-tissue sarcoma (51%) at age 13.3 (SD = 7.2) years. The neurocognitive battery included measures of attention, memory, motor-processing speed, and cognitive flexibility. Survivors reported health-damaging practices, which included: physical inactivity, smoking, alcohol intake, inadequate sleep (<7 h of actual sleep/day), sleep-related fatigue (Multidimensional Fatigue Scale) and long working hours (>9 h/day). General linear modeling was conducted to examine the association between lifestyle factors and neurocognitive outcomes, adjusting for age at diagnosis, sex, education attainment and clinical/treatment variables. Results: At 14.9 (SD = 7.6) years post-diagnosis, survivors demonstrated impairment in attentiveness (4.3–13.0%), processing speed (34.5%) and cognitive flexibility (18.1%). Nearly half (45.7%) had developed a chronic health condition (CHC). Low physical activity (estimate = −0.97, p = 0.003) and sleep-related fatigue (estimate = −0.08, p = 0.005) were associated with inattention. Survivors who worked >9 h/day (n = 15) demonstrated worse attention (estimate = 5.42, p = 0.023) and cognitive flexibility (estimate = 5.22, p = 0.005) than survivors who worked ≤9 h/day (n = 66). Interaction analysis (CHCs*physical activity) showed that survivors who developed CHCs and reported low physical activity had worse attention (p = 0.032) and cognitive-flexibility (p = 0.019) scores than other subgroups. Conclusion: Treatment-related CHCs, coupled with continued physical inactivity, may exacerbate inattention and executive dysfunction among survivors. Long working hours and sleep-related fatigue are associated with worse functioning; this finding should be validated with prospective assessment of work-related stressors and objective sleep measures. [ABSTRACT FROM AUTHOR]

Published
2023
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