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6. Allogeneic haematopoietic stem cell transplantation for mitochondrial neurogastrointestinal encephalomyopathy

Author

Halter, J. P, Michael, W, Schüpbach, M, Mandel, H, Casali, C, Orchard, K, Collin, M, Valcarcel, D, Rovelli, A, Filosto, M, Dotti, M. T, Marotta, G, Pintos, G, Barba, P, Accarino, A, Ferra, C, Illa, I, Beguin, Y, Bakker, J. A, Boelens, J. J, De Coo, I. F. M, Fay, K, Sue, C. M, Nachbaur, D, Zoller, H, Sobreira, C, Pinto Simoes, B, Hammans, S. R, Savage, D, Martí, R, Chinnery, P. F, Elhasid, R, Gratwohl, A, Hirano, M, Barros Navarro, G, Benoist, J. F, Bierau, J, Bucalossi, A, Carluccio, M. A, Coll-Canti, J, Cotelli, M. S, Diesch, T, Di Fabio, R, Donati, M. A, Garvin, J. H, Hill, K, Kappeler, L, Ku Hne, T, Lara, M. C, Lenoci, M, Lucchini, G, Marques, W. Jr, Mattle, H. P, Meyer, A, Parini, R, Passweg, J. R, Pieroni, F, Rodriguez-Palmero, A, Santus, F, Scarpelli, M, Schlesser, P, Sicurelli, F, Stern, M, Stracieri, A. B, Tonin, P, Torres-Torronteras, J, Voltarelli, J. C, Zaidman, I., Radiotherapy, and Neurology

Subjects
Male, DISORDER, Pathology, Neutrophils, medicine.medical_treatment, Neural Conduction, Hematopoietic stem cell transplantation, Gastroenterology, Liver disease, Fanconi anemia, risk factors, Non-U.S. Gov't, Child, 610 Medicine & health, Neurologic Examination, OUTCOMES, Ophthalmoplegia, Research Support, Non-U.S. Gov't, Hematopoietic Stem Cell Transplantation, Brain, THYMIDINE PHOSPHORYLASE-DEFICIENCY, Magnetic Resonance Imaging, Multicenter Study, Haematopoiesis, Treatment Outcome, mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), MNGIE, outcome, Female, Stem cell, Adult, medicine.medical_specialty, Adolescent, Thymidine phosphorylase activity, Research Support, thymidine phosphorylase, PATIENT, N.I.H, Young Adult, SDG 3 - Good Health and Well-being, Muscular Dystrophy, Oculopharyngeal, Research Support, N.I.H., Extramural, Mitochondrial Encephalomyopathies, Internal medicine, medicine, Journal Article, Humans, Transplantation, Homologous, Thymidine phosphorylase, Retrospective Studies, business.industry, MUTATIONS, MUTAÇÃO GENÉTICA, Body Weight, Intestinal Pseudo-Obstruction, Extramural, allogeneic haematopoietic stem cell transplantation, Original Articles, medicine.disease, Survival Analysis, Transplantation, DELETIONS, FANCONI-ANEMIA, Neurology (clinical), business, Follow-Up Studies
Abstract

Haematopoietic stem cell transplantation has been proposed as treatment for mitochondrial neurogastrointestinal encephalomyopathy, a rare fatal autosomal recessive disease due to TYMP mutations that result in thymidine phosphorylase deficiency. We conducted a retrospective analysis of all known patients suffering from mitochondrial neurogastrointestinal encephalomyopathy who underwent allogeneic haematopoietic stem cell transplantation between 2005 and 2011. Twenty-four patients, 11 males and 13 females, median age 25 years (range 10-41 years) treated with haematopoietic stem cell transplantation from related (n = 9) or unrelated donors (n = 15) in 15 institutions worldwide were analysed for outcome and its associated factors. Overall, 9 of 24 patients (37.5%) were alive at last follow-up with a median follow-up of these surviving patients of 1430 days. Deaths were attributed to transplant in nine (including two after a second transplant due to graft failure), and to mitochondrial neurogastrointestinal encephalomyopathy in six patients. Thymidine phosphorylase activity rose from undetectable to normal levels (median 697 nmol/h/mg protein, range 262-1285) in all survivors. Seven patients (29%) who were engrafted and living more than 2 years after transplantation, showed improvement of body mass index, gastrointestinal manifestations, and peripheral neuropathy. Univariate statistical analysis demonstrated that survival was associated with two defined pre-transplant characteristics: human leukocyte antigen match (10/10 versus

Published
2015

7. Role of interferon-alpha administration after 2-deoxycoformycin in the treatment of hairy cell leukemia patients

Author

Marotta, G., Frassoldati, A., Zinzani, P., Annino, L., Brugiatelli, M., Ambrosetti, A., Lenoci, M., Federico, Massimo, Foa, R., Lauria, F., the Italian Cooperative Group for HCL, Marotta G, Frassoldati A, Zinzani P.L., Annino L, Brugiatelli M, Ambrosetti A, Lenoci M, Federico M, Foa R, Lauria F, and Italian Cooperative group for HCL (ICGHCL).

Subjects
Male, Antimetabolites, Hairy Cell, Gastroenterology, Neoplasms, Life Tables, Leukemia, Hairy Cell, Hematology, Leukemia, Remission Induction, Neoplasms, Second Primary, General Medicine, Middle Aged, Antineoplastic, Combined Modality Therapy, 2-deoxycoformycin, hairy cell leukemia, interferon-alpha, Recombinant Proteins, Second Primary, Treatment Outcome, Italy, deoxycoformycin, Deoxycoformycin, Female, medicine.drug, Adult, medicine.medical_specialty, Antimetabolites, Antineoplastic, Randomization, Alpha interferon, Socio-culturale, Interferon alpha-2, Hairy cell leukemia, Disease-Free Survival, Internal medicine, medicine, Pentostatin, Humans, Immunologic Factors, 2'-Deoxycoformycin, Survival analysis, Interferon-alpha, Aged, Survival Analysis, business.industry, hairy cell leukemia • 2-deoxycoformycin • interferon-alpha, medicine.disease, Surgery, business, hairy cell leukemia, interferon-alpha, deoxycoformycin
Abstract

BACKGROUND AND OBJECTIVE: Hairy cell leukemia (HCL) is a rare chronic B-cell lymphoproliferative disorder which is treated effectively by interferon-alpha (IFN-alpha), deoxycoformycin (DCF) and 2-clorodeoxyadenosine (2-CdA). As a third of patients treated with DCF do not achieve a complete remission (CR) and many of them tend to relapse, we evaluated the potential role of IFN-alpha, randomly administered after DCF, in increasing the number of patients attaining CR and/or duration of CR. METHODS: From March 1997 to December 2000, 167 previously untreated HCL patients, from 37 Italian institutions, were enrolled in the study. A total of 138 males and 29 females, with a median age of 55 yr were included in the study. All patients received six courses of DCF 4 mg/m(2) i.v. every other week and then two additional courses once a month. Complete and partial responders were randomly assigned to receive or not receive IFN-alpha at a dose of 3 MU s.c. three times a week for 6 months. RESULTS: Of the 167 patients enrolled in the study, 145 (86.8%) obtained a CR or a partial remission (PR) and were therefore suitable for randomization. One hundred and thirty-five patients were successively randomized to receive IFN-alpha (63 cases; arm A) or not (72 cases; arm B). Progression of disease was observed in eight (arm A) and 12 (arm B) patients with a median time of 27.8 and 26.9 months, respectively. As far as the improvement in response was concerned, no significant difference in the two subgroups was observed. In fact, five patients in arm A and six patients in arm B showing a good PR at the end of DCF therapy, subsequently attained a late CR. CONCLUSIONS: From our data there does not appear to be any significant role for IFN-alpha in improving the proportion and the duration of CR in HCL patients previously treated with DCF.

Published
2006

9. Clinicobiological features in chronic lymphocytic leukemia with 14q32/IgH translocations

Author

Cavazzini, Francesco, RUSSO ROSSI, Antonella, Tiseo, Ruana, Maffei, R., Bardi, A., Tammiso, Elisa, Crupi, R., Lenoci, M. P., Rigolin, Gian Matteo, Marasca, R., Gozzetti, A., Hernandez, J. A., Lauria, F., Torelli, G., Castoldi, Gianluigi, and Cuneo, Antonio

Subjects
Clinicobiological features in chronic lymphocytic leukemia with 14q32/IgH translocations
Published
2006

11. Efficacy of anti-CD20 monoclonal antibodies (Mabthera) in patients with progressed hairy cell leukemia

Author

Lauria, F., Lenoci, M., Annino, L., Raspadori, D., Marotta, G., Bocchia, M., Forconi, F., Gentili, S., La Manda, M., Marconcini, S., Tozzi, M., Baldini, L., PIER LUIGI ZINZANI, and Foà, R.

Subjects
Adult, Murine-Derived, Male, Hairy Cell, administration /&/ dosage/pharmacokinetics, Antineoplastic Agents, anti-cd20, hcl, Antibodies, immunology, Antibodies, Monoclonal, Murine-Derived, rituximab, Monoclonal, 2-cda, Humans, CD20, Antigens, Aged, Leukemia, Hairy Cell, Leukemia, Adult, Aged, Antibodies, Murine-Derived, Antibodies, administration /&/ dosage/pharmacokinetics/therapeutic use, Antigens, immunology, Antineoplastic Agents, administration /&/ dosage/pharmacokinetics, Female, Humans, Leukemia, drug therapy, Male, Middle Aged, Remission Induction, Therapeutic Equivalency, Treatment Outcome, Remission Induction, dcf, Antibodies, Monoclonal, Middle Aged, Antigens, CD20, administration /&/ dosage/pharmacokinetics/therapeutic use, drug therapy, Treatment Outcome, Therapeutic Equivalency, Female
Abstract

Recently, a chimeric monoclonal antibody (MoAb) directed against the CD20 antigen (rituximab) has been successfully introduced in the treatment of several CD20-positive B-cell neoplasias and particularly of follicular lymphomas. Based on these premises we evaluated the efficacy and the toxicity of chimeric anti-CD20 monoclonal antibody (MoAb) in relapsed/progressed hairy cell leukemia (HCL).Ten patients with relapsed/progressed HCL entered the study. Eight patients were males and two females with a median age of 55 years (range 41-78) and all of them had been previously treated with 2-chlorodeoxyadenosine and/or deoxycoformycin and a-interferon. Two out of 10 patients were anemic (Hb10 g/dL), 4 thrombocytopenic (Plt100 x 10(9)/L), 3 had fewer than 1.0 x 10(9)/L neutrophils and 3 had circulating hairy cells (HC). All patients received 375 mg/m2 i.v. of anti-CD20 MoAb once a week for 4 doses.All patients were evaluable for response, one patient showing a complete remission and 4 a partial response. Adverse reactions, such as fever, chills, bone pain, hypotension and thrombocytopenia, were transient and mild (grade 1-2) and occurred only during the first course of treatment. One month after the last infusion, patients who had had anemia, neutropenia or thrombocytopenia, recovered normal peripheral blood values. Circulating HC also disappeared within one month. Immunostained bone marrow biopsies were checked 1, 3 and 6 months after the end of therapy and in 5 out of 10 patients a50% reduction of bone marrow HC infiltration was recorded.On the basis of these preliminary results observed in 10 patients with progressed HCL, it appears that treatment with anti-CD20 MoAb is safe and effective in at least 50% of patients, particularly in those with a less evident bone marrow infiltration (50%) and in those previously splenectomized.

Published
2001

13. CHOP-rituximab with pegylated liposomal doxorubicin for the treatment of elderly patients with diffuse large B-cell lymphoma.

Author

Zaja, F., Tomadini, V., Zaccaria, A., Lenoci, M., Battista, M., Molinari, A. L., Fabbri, A., Battista, R., Cabras, M. G., Gallamini, A., and Fanin, R.

Subjects
B cell lymphoma, LYMPHOMAS, DOXORUBICIN, RITUXIMAB, PREDNISONE, ECHOCARDIOGRAPHY, VINCRISTINE
Abstract

Thirty untreated patients, median age 69 years (range 60 – 75 years), with diffuse large B-cell lymphoma (B-DLCL) were treated with a pegylated liposomal doxorubicin (PL-doxorubicin) modified CHOP-rituximab regimen. PL-doxorubicin 30 mg/m2, was given in combination with standard dosage of prednisone, vincristine, cyclophosphamide, rituximab (according to CHOP-R regimen) every 21 days for six courses. Cardiac toxicity was evaluated by mean of echocardiography for left ventricular ejection fraction (LVEF) evaluations and serum troponin-I levels. Overall response and complete response rates were 76% and 59%. Projected two year event free survival and overall survival are 65.5% and 68.5%. No treatment-related mortality was documented. WHO grade III-IV neutropenia and thrombocytopenia were 86% and 3%. Extra-hematological III-IV toxicity was represented, respectively, by a single case of infection, mucositis, and bleeding. LVEF evaluations and the troponin levels did not show significant changes over the course of the treatment. One patient with a previous history of atrial fibrillation experienced a single episode of arrhythmia. None of the patients developed palmar-plantar erythrodysesthesia.This regimen appears an active regimen for the treatment of elderly patients with B-DLCL. The replacement of conventional doxorubicin with PL-doxorubicin seems to be associated with a negligible incidence of extra-hematological toxicity, in particular cardiac and infectious complications. [ABSTRACT FROM AUTHOR]

Published
2006
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14. Long-lasting decrease of CD4+/CD45RA+ T cells in HCL patients after 2-chlorodeoxyadenosine (2-CdA) treatment.

Author

Raspadori, D, Rondelli, D, Birtolo, S, Lenoci, M, Nardi, G, Scalia, G, Sestigiani, C, Tozzi, M, Marotta, G, and Lauria, F

Subjects
LEUCOCYTES, T cells, ANTIGENS
Abstract

The CD45RA and CD45RO isoforms of the leukocyte common antigen identify functionally distinct CD4+ T cell subsets: CD4+/CD45RA+ cells which represent a more 'naive' stage of T cell compartment and CD4+/CD45RO+ 'memory' cells. Phenotypic and functional abnormalities in T cell compartment have been frequently reported in patients with hairy cell leukemia (HCL) and, in more recent studies, a significant reduction in the absolute number of CD4+ lymphocytes bearing the CD45RO antigen has also been recorded. In our study we evaluated the CD45RA and CD45RO expression on CD4+ T cells by three-color staining in flow cytometry in 38 HCL patients, 19 untreated and 19 previously treated with 2-chlorodeoxyadenosine (2-CdA), administered at a daily dose of 0.1 mg/kg c.i. for 7 days. In HCL untreated patients, the proportion and the absolute number of CD4+/CD45RA+ and of CD4+/CD45RO+ T cell subsets were similar to normal controls. In contrast, HCL patients at 3-5 years by the end of treatment with 2-CdA, together with a reduction in the absolute number of CD4+ T cells, showed a persistent and significant decrease in the proportion and absolute number of CD4+/CD45RA+ cells as compared with both untreated HCL patients and normal controls (41 +/- 16% vs 57 +/- 14% and vs 65 +/- 7%) (P = 0.01 and 0.0001) and (0.201 +/- 0.137 x 10(9)/l vs 0.549 +/- 0.238 x 10(9)/l and vs 0.696 +/- 0.078 x 10(9)/l) (P = 0.00009 and P = 0.00001). In addition, together with the reduction of CD4+/CD45RA+ cells, we recorded a concomitant increase in the proportion of the CD4+/CD45RO+ cells as compared to untreated HCL patients and normal controls (62 +/- 16% vs 47 +/- 15% and vs 42 +/- 12%) (P = 0.08 and 0.02). These findings may suggest that CD4+/CD45RA+ cells are more sensitive than CD4+/CD45RO+ to the toxic effect of 2-CdA. [ABSTRACT FROM AUTHOR]

Published
1999
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17. No improvement of posttraumatic stress disorder symptoms with guanfacine treatment.

Author

Neylan TC, Lenoci M, Samuelson KW, Metzler TJ, Henn-Haase C, Hierholzer RW, Lindley SE, Otte C, Schoenfeld FB, Yesavage JA, and Marmar CR

Abstract

OBJECTIVE: The authors report an 8-week, double-blind, randomized controlled trial of guanfacine versus placebo for posttraumatic stress disorder (PTSD). METHOD: Veterans with chronic PTSD who were medication-free or receiving stable pharmacotherapy were randomly assigned to guanfacine (N=29) versus placebo (N=34). RESULTS: Guanfacine had no effect on PTSD symptoms, subjective sleep quality, or general mood disturbances. Guanfacine was associated with a number of side effects. CONCLUSIONS: These results do not support the use of alpha 2 agonists in veterans with chronic PTSD. [ABSTRACT FROM AUTHOR]

Published
2006
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19. Response of plasma profiles to neutral beam power deposition in ASDEX

Author

Speth, E., Gruber, O., Lackner, K., Riedler, H., Stäbler, A., Vollmer, O., Becker, G., Bosch, H., Brocken, H., Carlson, A., Eberhagen, A., Dodel, G., Fahrbach, H., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Haas, G., Herrmann, W., Hofmann, J., Izvozchikov, A., Holzhauer, E., Hübner, K., Janeschitz, G., Karger, F., Kaufmann, M., Klüber, O., Kornherr, M., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Mueller, E., Murmann, H., Neuhauser, J., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Rudyj, A., Schneider, F., Setzensack, C., Siller, G., Söldner, F., Steinmetz, K., Steuer, K., Ugniewski, S., Wagner, F., and Zasche, D.

Published
1987

20. Neutral beam deposition experiments at elevated densities in ASDEX

Author

Speth, E., Gruber, O., Janeschitz, G., Murmann, H., Niedermeyer, H., Wagner, F., Vollmer, O., Becker, G., Bosch, H., Brocken, H., Eberhagen, A., Fussmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Haas, G., Hofmann, J., Jzvozchikov, A., Karger, F., Keilhacker, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Müller, E., Pietrzyk, A., Poschenrieder, W., Rapp, H., Riedler, H., Röhr, H., Roth, J., Ryter, F., Schneider, J., Setzensach, C., Siller, G., Smeulders, P., Söldner, F., Steuer, K., and Zasche, D.

Published
1986

21. Energy and particle transport in medium-density ASDEX pellet discharges

Author

Gruber, O., Jilge, W., Mertens, V., Vlases, G., Kaufmann, M., Lang, R., Sandmann, W., Büchl, K., Bosch, H., Brocken, H., Eberhagen, A., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Haas, G., Hofmann, J., Janeschitz, G., Karger, F., Keilhacker, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mueller, E., Murmann, H., Niedermeyer, H., Poschenrieder, W., Rapp, H., Röhr, H., Ryter, F., Schneider, F., Setzensack, C., Siller, G., Smeulders, P., Söldner, F., Steuer, K., Wagner, F., and Zasche, D.

Published
1986

22. Parametric Behavior of the Density Profile in the Scrape-off Layer of ASDEX for Neutral-Beam-Heated Plasmas in the L-Regime

Author

McCormick, K., Pietrzyk, Z., Murmann, H., Becker, G., Bosch, H., Brocken, H., Carlson, A., Eberhagen, A., Dodel, G., Fahrbach, H., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Herrmann, W., Hofmann, J., Izvozchikov, A., Holzhauer, E., Hübner, K., Janeschitz, G., Karger, F., Kaufmann, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., Meisel, D., Mertens, V., Mueller, E., Neuhauser, J., Niedermeyer, H., Poschenrieder, W., Rapp, H., Rudyj, A., Schneider, F., Setzensack, C., Siller, G., Speth, E., Söldner, F., Steinmetz, K., Steuer, K., Tsois, N., Ugniewski, S., Vollmer, O., Wagner, F., and Zasche, D.

Published
1987

23. Transport in beam-heated ASDEX discharges below and in the vicinity of the beta limit

Author

Gruber, O., Jilge, W., Bosch, H., Brocken, H., Eberhagen, A., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Haas, G., Hofmann, J., Janeschitz, G., Izvozchikov, A., Karger, F., Keilhacker, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Mueller, E., Murmann, H., Niedermeyer, H., Poschenrieder, W., Rapp, H., Riedler, H., Röhr, H., Roth, J., Ryter, F., Schneider, F., Setzensack, C., Siller, G., Smeulders, P., Söldner, F., Speth, E., Steuer, K., Vollmer, O., and Wagner, F.

Published
1986

24. Profile evolution and particle transport close to the onset of sawtooth oscillations during the density ramp-up phase in ASDEX

Author

Gehre, O., Mertens, V., Kornherr, M., Müller, E., Becker, G., Bosch, H., Brocken, H., Carlson, A., Eberhagen, A., Dodel, G., Fahrbach, H., Fussmann, G., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Herrmann, W., Hofmann, J., Izvozchikov, A., Holzhauer, E., Hübner, K., Janeschitz, G., Karger, F., Kaufmann, M., Klüber, O., Lackner, K., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Murmann, H., Neuhauser, J., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Rudyj, A., Schneider, F., Setzensack, C., Siller, G., Speth, E., Soeldner, F., Steinmetz, K., Steuer, K., Ugniewski, S., Vollmer, O., Wagner, F., and Zasche, D.

Published
1987

25. Particle transport in sawteeth

Author

Zasche, D., Mertens, V., Gehre, O., Kaufmann, M., Röhr, H., Steuer, K., Becker, G., Bosch, H., Brocken, H., Carlson, A., Eberhagen, A., Dodel, G., Fahrbach, H., Fussmann, G., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Herrmann, W., Hofmann, J., Izvozchikov, A., Holzhauer, E., Hübner, K., Janeschitz, G., Karger, F., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mayer, H., Mast, F., McCormick, K., Meisel, D., Müller, E., Murmann, H., Neuhauser, J., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Rudyj, A., Schneider, F., Setzensack, C., Siller, G., Speth, E., Soeldner, F., Steinmetz, K., Ugniewski, S., Vollmer, O., and Wagner, F.

Published
1987

26. Poloidal Asymmetric Impurity Radiation in Asdex in the Presence of Neutral Injection

Author

Feneberg, W., Kornherr, M., Smeulders, P., Bartimoro, R., Becker, G., Bosch, H., Brocken, H., Eberhagen, A., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Giuliana, A., Glock, E., Gruber, O., Haas, G., Janeschitz, G., Karger, F., Keilhacker, M., Klüber, O., Kotze, P., Lackner, K., Lenoci, M., Lisitano, G., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Müller, E., Murmann, H., Niedermeyer, H., Poschenrieder, W., Rapp, H., Röhr, H., Ryter, F., Schneider, F., Siller, G., Söldner, F., Speth, E., Steuer, K., Vlases, G., Vollmer, O., and Wagner, F.

Published
1985

27. Particle confinement in ohmically heated ASDEX plasmas

Author

Gehre, O., Becker, G., Eberhagen, A., Bosch, H., Brocken, H., Fußmann, G., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Hofmann, J., Izvozchikov, A., Janeschitz, G., Karger, F., Keilhacker, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Mueller, E., Murmann, H., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Röhr, H., Roth, J., Ryter, F., Schneider, F., Setzensack, C., Siller, G., Smeulders, P., Söldner, F., Steuer, K., Wagner, F., and Zasche, D.

Published
1986

28. Measurement of plasma emission profiles in the range from 800 - 1000 nm for ZEFF-analysis in ASDEX

Author

Röhr, H., Steuer, K., Meisel, D., Murmann, H., Becker, G., Bosch, H., Brocken, H., Eberhagen, A., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Hofmann, J., Izvozchikov, A., Janeschitz, G., Karger, F., Keilhacker, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Mertens, V., Müller, E., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Roth, J., Ryter, F., Schneider, F., Setzensack, C., Siller, G., Smeulders, P., Söldner, F., Wagner, F., and Zasche, D.

Published
1986

29. The role of the Faraday screen in ICRF antennae: Comparison of an optically open and optically closed screen in ASDEX

Author

Noterdaeme, J., Ryter, F., Söll, M., Bäumler, J., Becker, G., Bosch, H., Brambilla, M., Braun, F., Brocken, H., Eberhagen, A., Fritsch, R., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Hofmann, J., Hofmeister, F., Izvozchikov, A., Janeschitz, G., Karger, F., Keilhacker, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mark, E., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Mueller, E., Murmann, H., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Puri, S., Rapp, H., Riedler, H., Röhr, H., Roth, J., Schneider, F., Setzensack, C., Siller, G., Smeulders, P., Söldner, F., Speth, E., Steinmetz, K., Steuer, K., Vollmer, O., Wagner, F., Wesner, F., Wedler, H., and Zasche, D.

Published
1986

30. Increase of the density limit in ASDEX by repetitive pellet injection

Author

Niedermeyer, H., Büchl, K., Kaufmann, M., Lang, R., Mertens, V., Sandmann, W., Vlases, G., Becker, G., Bosch, H., Brocken, H., Eberhagen, A., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Hofmann, J., Izvozchikov, A., Janeschitz, G., Karger, F., Keilhacker, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Müller, E., Murmann, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Riedler, H., Röhr, H., Roth, J., Ryter, F., Schneider, F., Setzensack, C., Siller, G., Smeulders, P., Söldner, F., Speth, E., Steuer, K., Vollmer, O., Wagner, F., and Zasche, D.

Published
1986

31. Plasma edge effects with ICRF in ASDEX

Author

Noterdaeme, J., Janeschitz, G., McCormick, K., Neuhauser, J., Roth, J., Ryter, F., Taglauer, E., Tsois, N., Brambilla, M., Carlson, A., Fußmann, G., Haas, G., Hofmeister, F., Mertens, V., Setzensack, C., Steinmetz, K., Wagner, F., Wesner, F., Bäumler, J., Becker, G., Becker, W., Bosch, H., Braun, F., Brocken, H., Eberhagen, A., Dodel, G., Fahrbach, H., Fritsch, R., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Herrmann, W., Hofmann, J., Izvozchikov, A., Holzhauer, E., Hübner, K., Karger, F., Kaufmann, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., Meisel, D., Mueller, E., Murmann, H., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Puri, S., Rapp, H., Riedler, H., Rudyj, A., Schneider, F., Siller, G., Speth, E., Söldner, F., Stäbler, A., Staudenmaier, G., Steuer, K., Ugniewski, S., Verbeek, H., Vollmer, O., Wedler, H., and Zasche, D.

Published
1987

32. The Transient Behaviour of the Beta Limit in ASDEX

Author

v. Gierke, G., Keilhacker, M., Bartiromo, R., Becker, G., Bosch, H., Eberhagen, A., Fußmann, G., Gehre, O., Gernhardt, J., Glock, E., Gruber, O., Haas, G., Janeschitz, G., Karger, F., Klüber, O., Kornherr, M., Kotze, P., Lackner, K., Lenoci, M., Lisitano, G., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Müller, E., Murmann, H., Niedermeyer, H., Poschenrieder, W., Rapp, H., Ryter, F., Schneider, F., Siller, G., Smeulders, P., Söldner, F., Speth, E., Steuer, K., Vollmer, O., and Wagner, F.

Published
1985

34. MHD-Effects with NI and ICRF heating on ASDEX

Author

Kornherr, M., Eberhagen, A., Gernhardt, J., Klüber, O., Wagner, F., Becker, G., Bosch, H., Brocken, H., Fußmann, G., Gehre, O., Gierke, G., Glock, E., Gruber, O., Haas, G., Hofmann, J., Izvozchikov, A., Janeschitz, G., Karger, F., Keilhacker, M., Lackner, K., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Müller, E., Murmann, H., Niedermeyer, H., Noterdaeme, J., Pietrzyk, A., Poschenrieder, W., Rapp, H., Riedler, H., Röhr, H., Roth, J., Ryter, F., Schneider, F., Setzensack, C., Siller, G., Smeulders, P., Söldner, F., Speth, E., Steinmetz, K., Steuer, K., Vollmer, O., Wesner, F., and Zasche, D.

Published
1986

35. Evolution of radiation power profiles in ASDEX h-mode discharges

Author

Mueller, E., Janeschitz, G., Smeulders, P., Fußmann, G., Kornherr, M., Mast, K., Becker, G., Bosch, H., Brocken, H., Eberhagen, A., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Hofmann, J., Izvozchikov, A., Karger, F., Keilhacker, M., Klüber, O., Lackner, K., Lenoci, M., Lisitano, G., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Murmann, H., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Riedler, H., Röhr, H., Roth, J., Ryter, F., Schneider, F., Setzensack, C., Siller, G., Söldner, F., Speth, E., Steuer, K., Vollmer, O., Wagner, F., and Zasche, D.

Published
1986

36. Periodic thomson scattering diagnostic with 16 spatial channels on ASDEX

Author

Meisel, D., Murmann, H., Röhr, H., Steuer, K., Becker, G., Bosch, H., Brocken, H., Eberhagen, A., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Hofmann, J., Izvozchikov, A., Janeschitz, G., Karger, F., Keilhacker, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Mertens, V., Müller, E., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Roth, J., Ryter, F., Schneider, F., Setzensack, C., Siller, G., Smeulders, P., Söldner, F., Wagner, F., and Zasche, D.

Published
1986

37. Measurements of non-thermal electron population during lower-hybrid heating in ASDEX

Author

Bartiromo, R., Hesse, M., Söldner, F., Burhenn, R., Fussmann, G., Leuterer, F., Murmann, H., Eckhartt, D., Eberhagen, A., Giuliana, A., Becker, G., Bosch, H., Brambilla, M., Brocken, H., Derfler, H., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Hofmann, J., Izvozchikov, A., Janeschitz, G., Karger, F., Keilhacker, M., Klüber, O., Kornherr, M., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Müller, E., Münich, M., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Röhr, H., Ruhs, N., Ryter, F., Schneider, F., Setzensack, C., Siller, G., Smeulders, P., Steuer, K., Vien, T., Wagner, F., Woyna, F., Zasche, D., and Zouhar, M.

Published
1986

38. Measurements of charged fusion products in ASDEX

Author

Bosch, H., Schumacher, U., Becker, G., Brocken, H., Eberhagen, A., Eckhartt, D., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Hofmann, J., Izvozchikov, A., Janeschitz, G., Karger, F., Keilhacker, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Leuterer, F., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Müller, E., Murmann, H., Niedermeyer, H., Noterdaeme, J., Pietrzyk, A., Poschenrieder, W., Rapp, H., Riedler, H., Röhr, H., Roth, J., Ryter, F., Speth, E., Schneider, F., Setzensack, C., Siller, G., Smeulders, P., Soeldner, F., Steinmetz, K., Steuer, K., Vollmer, O., Wagner, F., Wesner, F., and Zasche, D.

Published
1986

39. Impurity Behaviour for Various Auxiliary Heating Methods in ASDEX

Author

Fußmann, G., Bartiromo, R., Janeschitz, G., Kotze, P., Mueller, E., Soeldner, F., Bosch, H., Eberhagen, A., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Karger, F., Keilhacker, M., Kislyakov, A., Klüber, O., Kornherr, M., Lenoci, M., Lisitano, G., Mahdavi, A., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Murmann, H., Niedermeyer, H., Poschenrieder, W., Rapp, H., Ryter, F., Roth, J., Schneider, F., Siller, G., Smeulders, P., Speth, E., Steinmetz, K., Steuer, K., Vollmer, O., Wagner, F., and Wesner, F.

Published
1985

40. Confinement Studies on ASDEX in the Intermediate Region from Ohmic to Neutral Injection Scaling

Author

Wagner, F., Gruber, O., Bartiromo, R., Becker, G., Bosch, H., Eberhagen, A., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Haas, G., Janeschitz, G., Karger, F., Keilhacker, M., Kislyakov, A., Klüber, O., Kornherr, M., Kotze, F., Lackner, K., Lenoci, M., Lisitano, G., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Mueller, E., Murmann, H., Niedermeyer, H., Poschenrieder, W., Rapp, H., Riedler, H., Ryter, F., Roth, J., Schneider, F., Siller, G., Smeulders, P., Soeldner, F., Speth, E., Steinmetz, K., Steuer, K., and Vollmer, O.

Published
1985

41. ICRF h-mode and 2CHD(H)-Minority heating on ASDEX

Author

Steinmetz, K., Wagner, F., Wesner, F., Izvozchikov, A., Noterdaeme, J., Ryter, F., Bäumler, J., Becker, G., Bosch, H., Brambilla, M., Braun, F., Brocken, H., Eberhagen, A., Fritsch, R., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Hofmann, J., Hofmeister, F., Janeschitz, G., Karger, F., Keilhacker, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mark, E., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Mueller, E., Murmann, H., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Puri, S., Rapp, H., Röhr, H., Roth, J., Schneider, F., Setzensack, C., Siller, G., Smeulders, P., Söldner, F., Speth, E., Steuer, K., Vollmer, O., Wedler, H., and Zasche, D.

Published
1986

42. Radiation behaviour of gas and pellet refuelled high density discharges in ASDEX

Author

Mast, K., Müller, E., Fahrbach, H., Krause, H., Lang, R., McCarthy, P., Sandmann, W., Zasche, D., Becker, G., Bosch, H., Brocken, H., Carlson, A., Eberhagen, A., Dodel, G., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Herrmann, W., Hofmann, J., Izvozchikov, A., Holzhauer, E., Hübner, K., Janeschitz, G., Karger, F., Kaufmann, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Murmann, H., Neuhauser, J., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Rudyj, A., Schneider, F., Setzensack, C., Siller, G., Speth, E., Söldner, F., Steinmetz, K., Steuer, K., Ugniewski, S., Vollmer, O., and Wagner, F.

Published
1987

43. Study of impurity accumulation in the ASDEX Tokamak

Author

Fußmann, G., Janeschitz, G., Becker, G., Bosch, H., Brocken, H., Carlson, A., Eberhagen, A., Dodel, G., Fahrbach, H., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Herrmann, W., Hofmann, J., Izvozchikov, A., Holzhauer, E., Hübner, K., Karger, F., Kaufmann, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mayer, H., Mast, F., McCormick, K., Meisel, D., Mertens, V., Müller, E., Murmann, H., Neuhauser, J., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Rudyj, A., Schneider, F., Setzensack, C., Siller, G., Speth, E., Soeldner, F., Steinmetz, K., Steuer, K., Tsois, N., Ugniewski, S., Vollmer, O., Wagner, F., and Zasche, D.

Published
1987

44. Analysis of the invariance property of the electron temperature during auxiliary heating in ASDEX

Author

Murmann, H., Wagner, F., Becker, G., Bosch, H., Brocken, H., Eberhagen, A., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Hofmann, J., Izvozchikov, A., Janeschitz, G., Karger, F., Keilhacker, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Mueller, E., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Röhr, H., Roth, J., Ryter, F., Schneider, F., Setzensack, C., Siller, G., Smeulders, P., Söldner, F., Steuer, K., and Zasche, D.

Published
1986

45. MHD-Activities during pellet injection into ohmically and beam heated plasmas on ASDEX

Author

Kornherr, M., Gehre, O., Grassie, K., Klüber, O., Mertens, V., Becker, G., Bosch, H., Brocken, H., Büchl, K., Carlson, A., Eberhagen, A., Dodel, G., Fahrbach, H., Fußmann, G., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Herrmann, W., Hofmann, J., Izvozchikov, A., Holzhauer, E., Hübner, K., Janeschitz, G., Karger, F., Kaufmann, M., Lackner, K., Lang, R., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mueller, E., Murmann, H., Neuhauser, J., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Riedler, H., Rudyj, A., Sandmann, W., Schneider, F., Setzensack, C., Siller, G., Speth, E., Söldner, F., Stäbler, A., Steinmetz, K., Steuer, K., Tsois, N., Ugniewski, S., Vollmer, O., Wagner, F., and Zasche, D.

Published
1987

46. Impurity production during ICRF heating

Author

Janeschitz, G., Fußmann, G., Noterdaeme, J., Steinmetz, K., Izvozchikov, A., Ryter, F., Becker, G., Bosch, H., Brocken, H., Eberhagen, A., Gehre, O., Karger, F., Keilhacker, M., Klüber, O., Kornherr, M., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Mueller, E., Murmann, H., Niedermeyer, H., Poschenrieder, W., Rapp, H., Röhr, H., Schneider, F., Setzensack, C., Siller, G., Smeulders, P., Söldner, F., Speth, E., Steuer, K., Ugniewski, S., Vollmer, O., Wagner, F., Wesner, F., and Zasche, D.

Published
1986

47. Probe measurements of plasma inhomogeneities in the scrape-off layer of ASDEX during LH

Author

Lenoci, M., Haas, G., Becker, G., Bosch, H., Brocken, H., Eberhagen, A., Eckhartt, D., Hofmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Hofmann, J., Izvozchikov, A., Janeschitz, G., Karger, F., Keilhacker, M., Klüber, O., Kornherr, M., Lackner, K., Leuterer, F., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Müller, E., Murmann, H., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Röhr, H., Roth, J., Ryter, F., Schneider, F., Setzensack, C., Siller, G., Smeulders, P., Söldner, F., Steuer, K., Tsois, N., Wagner, F., and Zasche, D.

Published
1986

48. The study of runaway electron confinement to probe the electromagnetic turbulence in OH, L-and H-discharges of ASDEX

Author

Wagner, F., Fußmann, G., Becker, G., Bosch, H., Brocken, H., Carlson, A., Eberhagen, A., Dodel, G., Fahrbach, H., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Herrmann, W., Hofmann, J., Izvozchikov, A., Holzhauer, E., Hübner, K., Janeschitz, G., Karger, F., Kaufmann, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mast, F., Mayer, H., McCormick, K., Meisel, D., Mertens, V., Müller, E., Murmann, H., Neuhauser, J., Niedermeyer, H., Pietrzyk, A., Poschenrieder, W., Rapp, H., Rudy, A., Schneider, F., Setzensack, C., Siller, G., Speth, E., Söldner, F., Steinmetz, K., Steuer, K., Tsois, N., Ugniewski, S., Vollmer, O., and Zasche, D.

Published
1987

49. ASDEX Papers at the 13th European Conference on Controlled Fusion and Plasma Physics. Schliersee, April 14 - 18, 1986

Author

Wagner, F., Kaufmann, M., Niedermeyer, H., Gruber, O., Murmann, H., Gehre, O., Speth, E., Becker, G., Battiston, L., v. Gierke, G., Zehrfeld, H. P., Klüber, O., Kornherr, M., Steinmetz, K., Noterdaeme, J.-M., Ryter, F., Söldner, F., Leuterer, F., Bartiromo, R., McCormick, K., Lenoci, M., Zouhar, M., Müller, E. R., Janeschitz, G., Poschenrieder, W., Bosch, H. S., Meisel, D., and Röhr, H.

Published
1986

50. Comparison of ICRH and LH accelerated hydrogen ions in NI heated ASDEX plasmas

Author

Ryter, F., Brocken, H., Izvozchikov, A., Leuterer, F., Maaßberg, H., Mayer, H., Soeldner, F., Steinmetz, K., Becker, G., Bosch, H., Eberhagen, A., Eckhartt, D., Fußmann, G., Gehre, O., Gernhardt, J., Gierke, G., Glock, E., Gruber, O., Haas, G., Hofmann, J., Janeschitz, G., Karger, F., Keilhacker, M., Klüber, O., Kornherr, M., Lackner, K., Lenoci, M., Lisitano, G., Mast, F., McCormick, K., Meisel, D., Mertens, V., Müller, E., Murmann, H., Niedermeyer, H., Noterdaeme, J., Pietrzyk, A., Poschenrieder, W., Rapp, H., Riedler, H., Röhr, H., Roth, J., Schneider, F., Setzensack, C., Siller, G., Smeulders, P., Speth, E., Steuer, K., Vollmer, O., Wagner, F., Wesner, F., and Zasche, D.

Published
1986

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