Search

Your search keyword '"Lee, Yi-Pang"' showing total 151 results
Start Over Author "Lee, Yi-Pang" Language english
151 results on '"Lee, Yi-Pang"'

49. A Benzenoid 4,7-Dimethoxy-5-Methyl-L, 3-Benzodioxole from Antrodia cinnamomea Attenuates Dendritic Cell-Mediated Th2 Allergic Responses.

Author

You, Ren-In, Lee, Yi-Pang, Su, Ting-Yi, Lin, Chi-Chien, Chen, Chang-Shan, and Chu, Ching-Liang

Subjects
*ALLERGIES, *ANIMAL experimentation, *CELL surface antigens, *CHEMOKINES, *CYTOKINES, *DENDRITIC cells, *FLOW cytometry, *IMMUNODIAGNOSIS, *MICE, *MOLECULAR structure, *MUSHROOMS, *POLYMERASE chain reaction, *STATISTICAL hypothesis testing, *T cells, *T-test (Statistics), *PLANT extracts, *DATA analysis software, *BENZENE derivatives
Abstract

Dendritic cells (DCs) play a critical role in initiating immune responses; however, DCs also induce Th2-related allergic sensitivities. Thus, DCs become a target for therapeutic design in allergic diseases. In this study, we aim to investigate the anti-allergic effect of pure compounds from a medicinal mushroom Antrodia cinnamomea (Ac) on DC-induced allergic responses. We identified a benzenoid compound 4,7-dimethoxy-5-methyl-l,3-benzodioxole (DMB) which may modulate Th2 polarization in bone marrow-derived DCs (BMDCs) and in a murine food allergy model. DMB effectively reduced the Th2 adjuvant cholera toxin (CT)-induced BMDC maturation and cytokine production. In studying the mechanism, DMB blocked the molecular processes involved in Th2 induction, including cAMP activation, IL-33 production, and IRF4/Tim4 upregulation, in CT-activated BMDCs. Furthermore, DMB treatment attenuated the symptoms, clinical scores, and Th2 responses of CT-induced ovalbumin (OVA)-specific food allergy in mice at sensitization stage. These results indicated that DMB could suppress DC function for Th2 polarization and mitigate allergic responses. Thus, DMB may have potential to be a novel agent for preventing or treating food allergy. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

50. Fibrous dysplasia of the anterior mandible: A rare case report.

Author

Yang, Hsien-Yi, Su, Bor-Cherng, Hwang, Ming-Jay, and Lee, Yi-Pang

Abstract

Fibrous dysplasia (FD) is a rare bony disorder in which normal bone is replaced by abnormal fibro-osseous tissue. It often involves the long bones, craniofacial bones, ribs, and pelvis. Approximately 30% of monostotic FD (MFD) lesions are found in the cranial or facial bones. In general, FD is found in teenagers, and it usually becomes static after adulthood. FD involves the maxilla almost two times more often than the mandible. It frequently appears in the posterior region of the jaw bone and is usually unilateral. Here, we present an unusual case of symptomatic MFD affecting the anterior region of the mandible in a 43-year-old female with the clinical, radiographical, and histopathological features. The clinical examination showed both the labial and lingual bone expansion in the anterior mandible. The radiographic examination revealed a lesion with both radiopaque and radiolucent features showing a “ground-glass” appearance. The diagnosis was obtained after confirmatory intrabony biopsy with the histopathological examination, and it was diagnosed with benign FD. The patient preferred regular follow-up of MFD after discussion. During the regular follow-up, MFD lesion showed no obvious signs of progression or malignancy features. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results