1. Effects of 5-HT-1A receptor agonists on CRF-induced behavior.
- Author
-
Lazosky AJ and Britton DR
- Subjects
- 8-Hydroxy-2-(di-n-propylamino)tetralin, Animals, Buspirone pharmacology, Corticotropin-Releasing Hormone administration & dosage, Eating drug effects, Grooming drug effects, Injections, Intraventricular, Male, Motor Activity drug effects, Rats, Rats, Inbred Strains, Tetrahydronaphthalenes pharmacology, Behavior, Animal drug effects, Corticotropin-Releasing Hormone pharmacology, Receptors, Serotonin drug effects
- Abstract
Buspirone (2.0 or 4.0 mg/kg) and 8-hydroxy-2-(di-N-propylamino)-tetralin (8-OH-DPAT) (0.25 or 0.5 mg/kg) were used to examine the effects of serotonin 1A receptor agonists on the behavioral response of rats to centrally administered corticotropin-releasing factor (CRF). Behavioral observations were done with animals in their home cages. Parameters measured included locomotor activity, grooming and food consumption. CRF alone increased locomotor activity. 8-OH-DPAT also increased locomotion in both saline control and CRF-treated rats. Buspirone had no effect on basal locomotion or on CRF-induced hyperactivity. Both buspirone and 8-OH-DPAT antagonized CRF-induced grooming. Food consumption by fasted rats was suppressed by ICV CRF. 8-OH-DPAT suppressed eating by both ICV CRF and ICV saline-treated animals, while buspirone was without effect. These results demonstrate differences between the two putative 5-HT-1A agonists in their effects on CRF-induced behaviour but also demonstrate that both suppress CRF-induced grooming.
- Published
- 1991
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