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1. Metabolic syndrome criteria and severity and carbon dioxide (CO2) emissions in an adult population

Author

Silvia García, Rosario Pastor, Margalida Monserrat-Mesquida, Laura Álvarez-Álvarez, María Rubín-García, Miguel Ángel Martínez-González, Jordi Salas-Salvadó, Dolores Corella, Albert Goday, J. Alfredo Martínez, Ángel M. Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, José Lapetra, Lluís Serra-Majem, Blanca Riquelme-Gallego, Xavier Pintó, José J. Gaforio, Pilar Matía, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emilio Ros, Carmen Sayón-Orea, Patricia Guillem-Saiz, Cristina Valle-Hita, Robert Cabanes, Itziar Abete, Leire Goicolea-Güemez, Enrique Gómez-Gracia, Cristina Tercero-Maciá, Antoni Colom, Antonio García-Ríos, Sara Castro-Barquero, José C. Fernández-García, José Manuel Santos-Lozano, Juan Carlos Cenoz, Rocío Barragán, Nadine Khoury, Olga Castañer, María Ángeles Zulet, Jessica Vaquero-Luna, Maira Bes-Rastrollo, Sara de las Heras-Delgado, Ramon Ciurana, Vicente Martín-Sánchez, Josep A. Tur, and Cristina Bouzas

Subjects
Metabolic syndrome, Environment, CO2 emissions, Non-communicable diseases, Glycaemia, Diet, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Metabolic syndrome (MetS) has become a growing risk factor of some non-communicable diseases. Increase of greenhouse gas emissions affects the planet. Aims To assess the association between MetS severity and amount of carbon dioxide (CO2) emitted in an adult population. Design Cross-sectional study (n = 6646; 55-76-year-old-men; 60-75-year-old-women with MetS). Methods Dietary habits were assessed using a pre-validated semi quantitative 143-item food frequency questionnaire. The amount of CO2 emitted due to the production of food consumed by person and day was calculated using a European database, and the severity of the MetS was calculated with the MetS Severity Score. Results Higher glycaemia levels were found in people with higher CO2 emissions. The risk of having high severe MetS was related to high CO2 emissions. Conclusions Low CO2 emissions diet would help to reduce MetS severity. Advantages for both health and the environment were found following a more sustainable diet. Trial registration ISRCTN, ISRCTN89898870 . Registered 05 September 2013.

Published
2023
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2. Association Among Polyphenol Intake, Uric Acid, and Hyperuricemia: A Cross‐Sectional Analysis in a Population at High Cardiovascular Risk

Author

María Rubín‐García, Facundo Vitelli‐Storelli, Laura Álvarez‐Álvarez, Miguel Ángel Martínez‐González, Jordi Salas‐Salvadó, Dolores Corella, Álvaro Hernáez, J. Alfredo Martínez, Ángel M. Alonso‐Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López‐Miranda, Ramon Estruch, Francisco J. Tinahones, Luís I. Serra‐Majem, Naomi Cano‐Ibañez, Josep A. Tur, Alba Marcos‐Delgado, Anna Tresserra‐Rimbau, Xavier Pintó, Miguel Delgado‐Rodríguez, Pilar Matía‐Martín, Josep Vidal, Clotilde Vázquez, Lidia Daimiel, Emili Ros, Zenaida Vázquez‐Ruiz, Nancy Babio, Rocío Barragán, Olga Castañer‐Niño, Cristina Razquin, Lucas Tojal‐Sierra, Enrique Gómez‐Gracia, Sandra González‐Palacios, Marga Morey, Antonio García‐Rios, Sara Castro‐Barquero, María Rosa Bernal‐López, José Manuel Santos‐Lozano, Miguel Ruiz‐Canela, Antoni Castro‐Salomó, Eva Cristina Pascual‐Castelló, Verónica Moldon, Vanessa Bullón‐Vela, Carolina Sorto‐Sanchez, Juan Carlos Cenoz‐Osinaga, Liliana Gutiérrez, Maira Mengual, Rosa María Lamuela‐Raventós, and Vicente Martín‐Sánchez

Subjects
hyperuricemia, polyphenols, uric acid, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross‐sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol‐Explorer database. Multivariable‐adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow‐up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, −0.17 mg/dL for quintile 5 versus quintile 1 [95% CI, −0.27 to −0.06]) and hydroxycinnamic acids (β coefficient, −0.19 [95% CI, −0.3 to −0.09]), alkylmethoxyphenols (β coefficient, −0.2 [95% CI, −0.31 to −0.1]), and methoxyphenols (β coefficient, −0.24 [95% CI, −0.34 to −0.13]) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 [95% CI, 0.71–0.95]; PR, 0.82 [95% CI, 0.71–0.95]; PR, 0.80 [95% CI, 0.70–0.92]; and PR, 0.79 [95% CI, 0.69–0.91]; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 [95% CI, 0.02–0.26]) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research.

Published
2022
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3. Family history of first degree as a risk factor for colorectal cancer

Author

Pilar Amiano, Rocío Olmedo-Requena, Guillermo Fernández-Tardón, María Dolores-Chirlaque, María Rubín-García, Facundo Vitelli-Storelli, Yolanda Benavente, José Juan Jiménez-Moleón, Juan Alguacil, Marcela Guevara, Vicente Martín, Jéssica Alonso-Molero, Eva Ardanaz, Marina Pollán, Nuria Aragonés, Beatriz Pérez-Gómez, Laura Álvarez-Álvarez, Ana Molina-Barceló, Victor Moreno, Tania Fernández-Villa, Trinidad Dierssen-Sotos, Universidad de Cantabria, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Fundación Marqués de Valdecilla, International Cancer Genome Consortium, Ministerio de Economía y Competitividad (España), Red Temática de Investigación Cooperativa en Cáncer (España), Junta de Castilla y León (España), Regional Government of Andalusia (España), Generalitat Valenciana (España), Fundación La Caixa, Basque Government (España), Gobierno de la Región de Murcia (España), Unión Europea. Comisión Europea, Asociación Española Contra el Cáncer, Government of Catalonia (España), Fundación Caja de Ahorros de Asturias, University of Oviedo (España), Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España), Ministerio de Educación (España), and Agency for Administration of University and Research

Subjects
Factor de riesgo, Risk factors in diseases, Factor de riesgo Casos y controles, Family history, Risk Factors, Càncer colorectal, Odds Ratio, Malalties hereditàries, Humans, Family, Cáncer colorrectal, Casos y controles, Factors de risc en les malalties, Public Health, Environmental and Occupational Health, Antecedentes familiares, MCC-Spain, Middle Aged, Colorectal cancer, 3212 Salud Publica, Case and control, Spain, Risk factor, Colorectal Neoplasms, Genetic diseases
Abstract

La autora principal (garante responsable del manuscrito) afirma que este manuscrito es un reporte honesto, preciso y transparente del estudio que se remite a Gaceta Sanitaria, que no se han omitido aspectos importantes del estudio, y que las discrepancias del estudio según lo previsto (y, si son relevantes, registradas) se han explicado., A la Dra. Gemma Castaño Vinyals y al Dr. Manolis Kogevinas por su colaboración en el proyecto., Objetivo: El objetivo de este estudio es evaluar la asociación entre antecedentes familiares (AF) de primer grado y cáncer colorrectal (CCR). Método: Se incluyeron 2857 controles y 1360 casos de CCR, del estudio MCC-Spain. La odds ratio (OR) y el intervalo de confianza del 95% (IC95%) de los AF de primer grado y el CCR se estimaron mediante regresión logística no condicional según la localización tumoral en los casos. Resultados: Los AF de primer grado duplicaron el riesgo de CCR (OR: 2,19;IC95%: 1,80-2,66), incrementándose en aquellos que presentaban dos o más (OR: 4,22; IC95%: 2,29-7,78) y en aquellos cuyos familiares fueron diagnosticados antes de los 50 anos ˜ (OR: 3,24; IC95%: 1,52-6,91). Presentar AF se relacionó con estilos de vida como un menor consumo de vegetales. En cuanto a la asociación de los AF con la localización no se observaron diferencias significativas entre colon y recto, pero sí en la relación de estas con la edad de diagnóstico, presentando más AF los diagnosticados antes de los 50 anos ˜ (OR: 4,79; IC95%: 2,65-8,65). Conclusiones: Presentar AF de primer grado de CCR aumenta las probabilidades de desarrollar este cáncer, y también se elevan cuando el familiar es diagnosticado a edad temprana. Por ello, debe ser una población diana sobre la que incrementar las medidas de prevención., Objective: To evaluate the association between first-degree family history and colorectal cancer (CRC). Method: We analyzed data from 2857 controls and 1360 CRC cases, collected in the MCC-Spain project. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) of association with the family history of CRC was estimated by non-conditional logistic regression. Results: First-degree relatives doubled the risk of CRC (OR: 2.19; 95% CI: 1.80–2.66), increasing in those with two or more (OR: 4.22; 95% CI: 2.29–7.78) and in those whose relatives were diagnosed before 50 years (OR: 3.24; 95% CI: 1.52–6.91). Regarding the association of the family history with the location, no significant differences were observed between colon and rectum, but there were in the relation of these with the age of diagnosis, having more relatives those diagnosed before 50 years (OR: 4.79; 95% CI: 2.65–8.65). Conclusions: First-degree relatives of CRC increase the chances of developing this tumor,they also increase when the relative is diagnosed at an early age. Therefore, it must be a target population on which to carry out prevention measures., El estudio fue parcialmente financiado por la «Acción Transversal del Cáncer», aprobada por el Consejo del Ministerio de España el 11 de octubre de 2007, por el Instituto de Salud Carlos III-FEDER (PI08 / 1770, PI08 / 0533, PI08 / 1359, PS09 / 00773-Cantabria, PS09 / 01286-León, PS09 / 01903-Valencia, PS09 / 02078-Huelva, PS09 / 01662-Granada, PI11 / 01403, PI11 / 01889-FEDER, PI11 / 00226, PI11 / 01810, PI11 / 02213, PI12 / 00488, PI12 / 00265, PI12 / 01270, PI12 / 00715, PI12 / 00150, PI14 / 01219, PI14 / 0613, PI15 / 00069, PI15 / 00914, PI15 / 01032, PI17CIII / 00034), así como a través de CIBERESP CB06/02/0073, cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER). También cuenta con el apoyo de la Fundación Marqués de Valdecilla (API 10/09), el ICGC International Cancer Genome Consortium CLL (el proyecto ICGC CLL-Genome Project está financiado por el Ministerio de Economía y Competitividad española través del Instituto de Salud Carlos III y la Red Temática de Investigación del Cáncer del Instituto de Salud Carlos III [RD12 / 0036/0036]), la Junta de Castilla y León (LE22A10-2), la Consejería de Salud de la Junta de Andalucía (PI-0571-2009, PI-0306-2011, salud201200057018tra), la Conselleria de Sanitat de la Generalitat Valenciana (AP 061/10), RecerCaixa (2010ACUP 00310), el Gobierno Regional del País Vasco, la Consejería de Sanidad de la Región de Murcia, la Comisión Europea de subvenciones FOOD-CT-2006-036224-HIWATE, la Fundación Científica de la Asociación Española Contra el Cáncer (AECC), la Generalitat de Catalunya - Agencia de Gestión Universitaria e Investigación Becas (AGAUR) y 2017SGR01085. Becas 2017SGR723 y 2014SGR850 de la Fundación Caja de Ahorros de Asturias y de la Universidad de Oviedo. ISGlobal agradece el apoyo del Ministerio de Ciencia e Innovación de España través del Programa Centro de Excelencia Severo Ochoa 2019-2023 (CEX2018-000806-S), y el apoyo de la Generalitat de Catalunya a través del Programa CERCA. M. Rubín-García cuenta con el apoyo del Ministerio de Educación de España (FPU17/06488).

Published
2021

4. Net contribution and predictive ability of the CUN-BAE body fatness index in relation to cardiometabolic conditions

Author

Lidia García-Martínez, Miguel Delgado-Rodríguez, Fernanda de Souza-Teixeira, Rocío Olmedo-Requena, Antonio J. Molina, Heinz Freisling, Laura Vilorio-Marqués, Jorge Torre, Javier Llorca, Laura Álvarez-Álvarez, Leila Lujan-Barroso, Vicente Martín, Verónica Dávila-Batista, and Universidad de Cantabria

Subjects
0301 basic medicine, Adult, Male, Waist, Index (economics), Adolescent, Medicine (miscellaneous), 030209 endocrinology & metabolism, Logistic regression, CUN-BAE, Body Mass Index, 03 medical and health sciences, Young Adult, BMI, 0302 clinical medicine, Sex Factors, Risk Factors, Diabetes mellitus, medicine, Diabetes Mellitus, Humans, Obesity, Aged, Aged, 80 and over, Metabolic Syndrome, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, Diabetes, Body fatness, Age Factors, Original Contribution, Anthropometry, Middle Aged, medicine.disease, Metabolisme, Cross-Sectional Studies, Metabolism, Adipose Tissue, Spain, Hypertension, Obesitat, Female, Metabolic syndrome, business, Body Fatness, Body mass index, Demography
Abstract

Background The CUN-BAE (Clínica Universidad de Navarra-Body adiposity estimator) index is an anthropometric index based on age, sex and body mass index (BMI) for a refined prediction of body fatness in adults. CUN-BAE may help detect metabolically unhealthy individuals with otherwise normal weight according to BMI or waist circumference (WC). The aim of this study was to evaluate whether CUN-BAE, independent of its components (BMI, age and sex), was associated with cardiometabolic conditions including arterial hypertension, diabetes mellitus and metabolic syndrome (MetS). Methods The ENRICA study was based on a cross-sectional sample of non-institutionalized men and women representative of the adult Spanish population. Body weight, height, and WC were measured in all participants. The residual of CUN-BAE (rCUN-BAE), i.e. the part of the index not explained by its components, was calculated. The associations of CUN-BAE, rCUN-BAE, BMI and WC with hypertension, diabetes and MetS were analysed by multivariate logistic regression, and the Akaike information criterion (AIC) was calculated. Results The sample included 12,122 individuals. rCUN-BAE was associated with hypertension (OR 1.14, 95% CI 1.07–1.21) and MetS (OR 1.48, 1.37–1.60), but not with diabetes (OR 1.05, 0.94–1.16). In subjects with a BMI < 25 kg/m2, CUN-BAE was significantly associated with all three outcome variables. CUN-BAE was more strongly associated with the cardiometabolic conditions than BMI and WC and fit similar AICs. Conclusions The CUN-BAE index for body fatness was positively associated with hypertension, diabetes and MetS in adults independent of BMI or WC. CUN-BAE may help to identify individuals with cardiometabolic conditions beyond BMI, but this needs to be confirmed in prospective settings., The ENRICA study was funded and financed by Sanofi- Aventis. Specific funding for this analysis came from the governmental Spain FIS PI12/1166 and PI11/01379 projects and from the “UAM Chair in Epidemiology and Control of Cardiovascular Risk”.

Published
2019

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