464 results on '"Larsen, Steen"'
Search Results
2. Choice of medium affects PBMC quantification, cell size, and downstream respiratory analysis
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Bager Christensen, Ida, Ribas, Lucas, Mosshammer, Maria, Abrahamsen, Marie-Louise, Kühl, Michael, Larsen, Steen, Dela, Flemming, and Gillberg, Linn
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- 2024
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3. Acute antioxidant supplementation and performance – Should this be considered
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Larsen, Steen
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- 2024
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4. Harmonization of experimental procedures to assess mitochondrial respiration in human permeabilized skeletal muscle fibers
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Doerrier, Carolina, Gama-Perez, Pau, Pesta, Dominik, Distefano, Giovanna, Soendergaard, Stine D., Chroeis, Karoline Maise, Gonzalez-Franquesa, Alba, Goodpaster, Bret H., Prats, Clara, Sales-Pardo, Marta, Guimera, Roger, Coen, Paul M., Gnaiger, Erich, Larsen, Steen, and Garcia-Roves, Pablo M.
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- 2024
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5. Antioxidant enzymes and Nrf2/Keap1 in human skeletal muscle: Influence of age, sex, adiposity and aerobic fitness
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Galvan-Alvarez, Victor, Gallego-Selles, Angel, Martinez-Canton, Miriam, García-Gonzalez, Eduardo, Gelabert-Rebato, Miriam, Ponce-Gonzalez, Jesus Gustavo, Larsen, Steen, Morales-Alamo, David, Losa-Reyna, Jose, Perez-Suarez, Ismael, Dorado, Cecilia, Perez-Valera, Mario, Holmberg, Hans-Christer, Boushel, Robert, de Pablos Velasco, Pedro, Helge, Jorn Wulff, Martin-Rincon, Marcos, and Calbet, Jose A.L.
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- 2023
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6. Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration
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Pedersen, Julie S., Rygg, Marte O., Chrøis, Karoline, Sustarsic, Elahu G., Gerhart-Hines, Zach, Wever Albrechtsen, Nicolai J., Serizawa, Reza R., Kristiansen, Viggo B., Basse, Astrid L., Boilesen, Astrid E. B., Olsen, Beth H., Hansen, Torben, Gluud, Lise Lotte, Madsbad, Sten, Larsen, Steen, Bendtsen, Flemming, and Dela, Flemming
- Published
- 2022
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7. Mouse vascularized adipose spheroids: an organotypic model for thermogenic adipocytes.
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Ingeborg Davidsen, Laura, Hagberg, Carolina E., Goitea, Victor, Meinild Lundby, Stine, Larsen, Steen, Frendø Ebbesen, Morten, Stanic, Natasha, Topel, Hande, and Kornfeld, Jan-Wilhelm
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WHITE adipose tissue ,MICROPHYSIOLOGICAL systems ,BROWN adipose tissue ,ADIPOSE tissues ,FAT cells ,ENERGY metabolism ,TISSUE scaffolds ,GENE expression ,ADIPOGENESIS - Abstract
Adipose tissues, particularly beige and brown adipose tissue, play crucial roles in energy metabolism. Brown adipose tissues' thermogenic capacity and the appearance of beige cells within white adipose tissue have spurred interest in their metabolic impact and therapeutic potential. Brown and beige fat cells, activated by environmental factors like cold exposure or by pharmacology, share metabolic mechanisms that drive non-shivering thermogenesis. Understanding these two cell types requires advanced, yet broadly applicable in vitro models that reflect the complex microenvironment and vasculature of adipose tissues. Here we present mouse vascularized adipose spheroids of the stromal vascular microenvironment from inguinal white adipose tissue, a tissue with 'beiging' capacity in mice and humans. We show that adding a scaffold improves vascular sprouting, enhances spheroid growth, and upregulates adipogenic markers, thus reflecting increased adipocyte maturity. Transcriptional profiling via RNA sequencing revealed distinct metabolic pathways upregulated in our vascularized adipose spheroids, with increased expression of genes involved in glucose metabolism, lipid metabolism, and thermogenesis. Functional assessment demonstrated increased oxygen consumption in vascularized adipose spheroids compared to classical 2D cultures, which was enhanced by β-adrenergic receptor stimulation correlating with elevated b-adrenergic receptor expression. Moreover, stimulation with the naturally occurring adipokine, FGF21, induced Ucp1 mRNA expression in the vascularized adipose spheroids. In conclusion, vascularized inguinal white adipose tissue spheroids provide a physiologically relevant platform to study how the stromal vascular microenvironment shapes adipocyte responses and influence activated thermogenesis in beige adipocytes. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity
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Basse, Astrid L., Agerholm, Marianne, Farup, Jean, Dalbram, Emilie, Nielsen, Joachim, Ørtenblad, Niels, Altıntaş, Ali, Ehrlich, Amy M., Krag, Thomas, Bruzzone, Santina, Dall, Morten, de Guia, Roldan M., Jensen, Jonas B., Møller, Andreas B., Karlsen, Anders, Kjær, Michael, Barrès, Romain, Vissing, John, Larsen, Steen, Jessen, Niels, and Treebak, Jonas T.
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- 2021
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9. Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise
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Brandão, Bruna B., Madsen, Søren, Rabiee, Atefeh, Oliverio, Matteo, Ruiz, Gabriel P., Ferrucci, Danilo L., Branquinho, Jéssica L., Razolli, Daniela, Pinto, Silas, Nielsen, Thomas S., Festuccia, William T., Martins, Adriano S., Guerra, Beatriz A., Knittel, Thiago L., Søgaard, Ditte, Larsen, Steen, Helge, Jørn W., Brandauer, Josef, Velloso, Lício A., Emanuelli, Brice, Kornfeld, Jan-Wilhelm, Kahn, Ronald, Vienberg, Sara G., Zierath, Juleen R., Treebak, Jonas T., and Mori, Marcelo A.
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- 2020
10. Six weeks of high intensity cycle training reduces H2O2 emission and increases antioxidant protein levels in obese adults with risk factors for type 2 diabetes
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Flensted-Jensen, Mathias, Gram, Martin, Dela, Flemming, Helge, Jørn Wulff, and Larsen, Steen
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- 2021
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11. Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity
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Mendham, Amy E., Goedecke, Julia H., Zeng, Yingxu, Larsen, Steen, George, Cindy, Hauksson, Jon, Fortuin-de Smidt, Melony C., Chibalin, Alexander V., Olsson, Tommy, and Chorell, Elin
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- 2021
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12. The north wind: A critical perspective on the purposes of education
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Larsen, Steen Nepper and Boreland, Carly
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- 2021
13. Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise
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Hingst, Janne R., Kjøbsted, Rasmus, Birk, Jesper B., Jørgensen, Nicolas O., Larsen, Magnus R., Kido, Kohei, Larsen, Jeppe Kjærgaard, Kjeldsen, Sasha A.S., Fentz, Joachim, Frøsig, Christian, Holm, Stephanie, Fritzen, Andreas M., Dohlmann, Tine L., Larsen, Steen, Foretz, Marc, Viollet, Benoit, Schjerling, Peter, Overby, Peter, Halling, Jens F., Pilegaard, Henriette, Hellsten, Ylva, and Wojtaszewski, Jørgen F.P.
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- 2020
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14. Effect of repeated prolonged exercise on liver fat content and visceral adipose tissue in well‐trained older men.
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Poggi, Axel Illeris, Andreasen, Martin Winther, Sahl, Ronni Eg, Hansen, Mikkel Thunestvedt, Rømer, Tue, Frandsen, Jacob, Linden, Frederik Hvid, Høgh‐Schmidt, Erik, Boesen, Mikael Ploug, Ostrowski, Sisse Rye, Larsen, Steen, Dela, Flemming, and Helge, Jørn Wulff
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FATTY liver prevention ,EXERCISE physiology ,OXIDATION-reduction reaction ,EXERCISE ,ADIPOSE tissues ,FAT ,RESEARCH funding ,CLINICAL trials ,BODY composition ,DESCRIPTIVE statistics ,MAGNETIC resonance imaging ,ERGOMETRY ,EXERCISE intensity ,AEROBIC capacity ,CYCLING ,OLD age - Abstract
Introduction: Liver fat (LF) and visceral adipose tissue (VAT) content decreases with training, however, this has mainly been investigated in sedentary obese or healthy participants. The aim of this study was to investigate the effects of repeated prolonged exercise on LF and VAT content in well‐trained older men and to compare baseline LF and VAT content to recreationally active older men. Method: A group of five well‐trained older men were tested before and after cycling a total distance of 2558 km in 16 consecutive days. VAT content and body composition was measured using DXA before a bicycle ergometer test was performed to determine maximal fat oxidation (MFO), maximal oxygen consumption (VO2max$$ {\mathrm{VO}}_{2_{\mathrm{max}}} $$), and the relative intensity at which MFO occurred (Fatmax). LF content was measured on a separate day using MRI. For comparison of baseline values, a control group of eight healthy age‐ and BMI‐matched recreationally active men were recruited. Results: The well‐trained older men had lower VAT (p = 0.02), and a tendency toward lower LF content (p = 0.06) compared with the control group. The intervention resulted in decreased LF content (p = 0.02), but VAT, fat mass, and lean mass remained unchanged. VO2max$$ {\mathrm{VO}}_{2_{\mathrm{max}}} $$, MFO, and Fatmax were not affected by the intervention. Conclusion: The study found that repeated prolonged exercise reduced LF content, but VAT and VO2max$$ {\mathrm{VO}}_{2_{\mathrm{max}}} $$ remained unchanged. Aerobic capacity was aligned with lower LF and VAT in older active men. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected
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Christiansen, Liselotte Bruun, Dohlmann, Tine Lovsø, Ludvigsen, Trine Pagh, Parfieniuk, Ewa, Ciborowski, Michal, Szczerbinski, Lukasz, Kretowski, Adam, Desler, Claus, Tiano, Luca, Orlando, Patrick, Martinussen, Torben, Olsen, Lisbeth Høier, and Larsen, Steen
- Published
- 2021
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16. Actovegin improves skeletal muscle mitochondrial respiration and functional aerobic capacity in a type 1 diabetic male murine model.
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Kosik, Brandon, Larsen, Steen, and Bergdahl, Andreas
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BIOTHERAPY , *PROTEIN metabolism , *AEROBIC capacity , *DRUG efficacy , *ENERGY metabolism , *SKELETAL muscle , *BIOLOGICAL products , *INTRAVENOUS therapy , *FUNCTIONAL status , *ANIMAL experimentation , *TYPE 1 diabetes , *MITOCHONDRIA , *GENE expression , *TREATMENT effectiveness , *RATS , *COMPARATIVE studies , *QUADRICEPS muscle , *EXERCISE , *RESPIRATION , *BODY mass index , *EVALUATION - Abstract
Insulin deficiency in type 1 diabetes (T1D) leads to an impairment of glucose metabolism and mitochondrial function. Actovegin is a hemodialysate of calf blood, which has been shown to enhance glucose uptake and cell metabolism in healthy human skeletal muscle. The objectives of this study were to determine the effects of Actovegin on skeletal muscle mitochondrial respiration and functional aerobic capacity in a T1D mouse model. Effects on the expression of mitochondrial proteins, body mass, and food and water consumption were also investigated. Streptozotocin-induced T1D male C57B1/6 mice (aged 3–4 months) were randomized to an Actovegin group and a control group. Every third day, the Actovegin and control groups were injected intraperitoneally with (0.1 mL) Actovegin and (0.1 mL) physiological salt solution, respectively. Oxidative phosphorylation (OXPHOS) capacity of the vastus lateralis muscle was measured by high resolution respirometry in addition to the expression levels of the mitochondrial complexes as well as voltage-dependent anion channel. Functional aerobic capacity was measured using a rodent treadmill protocol. Body mass and food and water consumption were also measured. After 13 days, in comparison to the control group, the Actovegin group demonstrated a significantly higher skeletal muscle mitochondrial respiratory capacity in an ADP-restricted and ADP-stimulated environment. The Actovegin group displayed a significantly lesser decline in functional aerobic capacity and baseline body mass after 13 days. There were no significant differences in food or water consumption between groups. Actovegin could act as an effective agent for facilitating glucose metabolism and improving OXPHOS capacity and functional aerobic capacity in T1D. Further investigation is warranted to establish Actovegin's potential as an alternative therapeutic drug for T1D. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Prolonged Endurance Exercise Increases Macrophage Content and Mitochondrial Respiration in Adipose Tissue in Trained Men.
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Sahl, Ronni Eg, Patsi, Ioanna, Hansen, Mikkel Thunestvedt, Rømer, Tue, Frandsen, Jacob, Rasmusen, Hanne Kruuse, Ingersen, Arthur, Poulsen, Steen Seier, Dela, Flemming, Larsen, Steen, and Helge, Jørn Wulff
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ADIPOSE tissues ,MACROPHAGES ,EXERCISE therapy - Abstract
Background The aim of this study was to investigate the effect of prolonged endurance exercise on adipose tissue inflammation markers and mitochondrial respiration in younger and older men. Methods "Young" (aged 30 years, n = 7) and "old" (aged 65 years, n = 7) trained men were exposed to an exercise intervention of 15 consecutive days biking 7 to 9 hours/day at 63% and 65% of maximal heart rate (young and old, respectively), going from Copenhagen, Denmark to Palermo, Italy. Adipose tissue was sampled from both the gluteal and abdominal depot before and after the intervention. Mitochondrial respiration was measured by high-resolution respirometry, and adipose inflammation was assessed by immunohistochemical staining of paraffin embedded sections. Results An increased number of CD163+ macrophages was observed in both the gluteal and abdominal depot (P <.01). In addition, an increased mitochondrial respiration was observed in the abdominal adipose tissue from men in the young group with complex I (CI
p ) stimulated respiration, complex I + II (CI+IIp ) stimulated respiration and the capacity of the electron transport system (ETS) (P <.05), and in the older group an increase in CIp and CI+IIp stimulated respiration (P <.05) was found. Conclusion Overall, we found a positive effect of prolonged endurance exercise on adipose tissue inflammation markers and mitochondrial respiration in both young and old trained men, and no sign of attenuated function in adipose tissue with age. [ABSTRACT FROM AUTHOR]- Published
- 2024
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18. Combined changes in temperature and pH mimicking exercise result in decreased efficiency in muscle mitochondria.
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Flensted-Jensen, Mathias, Kleis-Olsen, Ann-Sofie, Hassø, Rasmus Kinimond, Lindtofte, Søren, Corral Pérez, Juan, Ortega-Gómez, Sonia, and Larsen, Steen
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MITOCHONDRIA ,ANAEROBIC threshold ,QUADRICEPS muscle ,OXIDATIVE phosphorylation ,TEMPERATURE effect ,LACTATES - Abstract
It is well known that exercise efficiency declines at intensities above the lactate threshold, yet the underlying mechanisms are poorly understood. Some have suggested it is due to a decline in mitochondrial efficiency, but this is difficult to examine in vivo. Therefore, the aim of the current study was to examine how changes in temperature and pH, mimicking those that occur during exercise, affect mitochondrial efficiency in skeletal muscle mitochondria. This study was performed on quadriceps muscle of 20 wild-type mice. Muscle tissue was dissected and either permeabilized (n = 10) or homogenized for isolation of mitochondria (n = 10), and oxidative phosphorylation capacity and P/O ratio were assessed using high-resolution respirometry. Samples from each muscle were analyzed in both normal physiological conditions (37℃, pH 7.4), decreased pH (6.8), increased temperature (40℃), and a combination of both. The combination of increased temperature and decreased pH resulted in a significantly lower P/O ratio, mirrored by an increase in leak respiration and a decrease in respiratory control ratio (RCR), in isolated mitochondria. In permeabilized fibers, RCR and leak were relatively unaffected, though a main effect of temperature was observed. Oxidative phosphorylation capacity was unaffected by changes in pH and temperature in both isolated mitochondria and permeabilized fibers. These results indicate that exercise-like changes in temperature and pH lead to impaired mitochondrial efficiency. These findings offer some degree of support to the concept of decreased mitochondrial efficiency during exercise, and may have implications for the assessment of mitochondrial function related to exercise. [ABSTRACT FROM AUTHOR]
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- 2024
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19. Variation in mitochondrial respiratory capacity and myosin heavy chain composition in repeated muscle biopsies
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Sahl, Ronni Eg, Morville, Thomas, Kraunsøe, Regitze, Dela, Flemming, Helge, Jørn Wulff, and Larsen, Steen
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- 2018
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20. PFE-360-induced LRRK2 inhibition induces reversible, non-adverse renal changes in rats
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Andersen, Michael Aagaard, Wegener, Karen Malene, Larsen, Steen, Badolo, Lassina, Smith, Garrick Paul, Jeggo, Ross, Jensen, Poul Henning, Sotty, Florence, Christensen, Kenneth Vielsted, and Thougaard, Annemette
- Published
- 2018
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21. Initial brain aging: heterogeneity of mitochondrial size is associated with decline in complex I-linked respiration in cortex and hippocampus
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Thomsen, Kirsten, Yokota, Takashi, Hasan-Olive, Md Mahdi, Sherazi, Niloofar, Fakouri, Nima Borhan, Desler, Claus, Regnell, Christine Elisabeth, Larsen, Steen, Rasmussen, Lene Juel, Dela, Flemming, Bergersen, Linda Hildegard, and Lauritzen, Martin
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- 2018
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22. ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine
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Fontana, Diletta, Mauri, Mario, Renso, Rossella, Docci, Mattia, Crespiatico, Ilaria, Røst, Lisa M., Jang, Mi, Niro, Antonio, D’Aliberti, Deborah, Massimino, Luca, Bertagna, Mayla, Zambrotta, Giovanni, Bossi, Mario, Citterio, Stefania, Crescenzi, Barbara, Fanelli, Francesca, Cassina, Valeria, Corti, Roberta, Salerno, Domenico, Nardo, Luca, Chinello, Clizia, Mantegazza, Francesco, Mecucci, Cristina, Magni, Fulvio, Cavaletti, Guido, Bruheim, Per, Rea, Delphine, Larsen, Steen, Gambacorti-Passerini, Carlo, and Piazza, Rocco
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- 2020
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23. Simvastatin improves mitochondrial respiration in peripheral blood cells
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Durhuus, Jon Ambæk, Hansson, Svenja, Morville, Thomas, Kuhlman, Anja Birk, Dohlmann, Tine Lovsø, Larsen, Steen, Helge, Jørn Wulff, Angleys, Maria, Muniesa-Vargas, Alba, Bundgaard, Jens R., Hickson, Ian David, Dela, Flemming, Desler, Claus, and Rasmussen, Lene Juel
- Published
- 2020
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24. Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus
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Jespersen, Nichlas Riise, Hjortbak, Marie Vognstoft, Lassen, Thomas Ravn, Støttrup, Nicolaj Brejnholt, Johnsen, Jacob, Tonnesen, Pernille Tilma, Larsen, Steen, Kimose, Hans-Henrik, and Bøtker, Hans Erik
- Published
- 2020
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25. Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function
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Mendham, Amy E., Larsen, Steen, George, Cindy, Adams, Kevin, Hauksson, Jon, Olsson, Tommy, Fortuin-de Smidt, Melony C., Nono Nankam, Pamela A., Hakim, Olah, Goff, Louise M., Pheiffer, Carmen, and Goedecke, Julia H.
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- 2020
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26. Acute Deletion of the Glucocorticoid Receptor in Hepatocytes Disrupts Postprandial Lipid Metabolism in Male Mice.
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Correia, Catarina Mendes, Præstholm, Stine Marie, Havelund, Jesper Foged, Pedersen, Felix Boel, Siersbæk, Majken Storm, Ebbesen, Morten Frendø, Gerhart-Hines, Zach, Heeren, Joerg, Brewer, Jonathan, Larsen, Steen, Blagoev, Blagoy, Færgeman, Nils Joakim, and Grøntved, Lars
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GLUCOCORTICOID receptors ,LIVER cells ,LIPID metabolism - Abstract
Hepatic lipid metabolism is highly dynamic, and disruption of several circadian transcriptional regulators results in hepatic steatosis. This includes genetic disruption of the glucocorticoid receptor (GR) as the liver develops. To address the functional role of GR in the adult liver, we used an acute hepatocyte-specific GR knockout model to study temporal hepatic lipid metabolism governed by GR at several preprandial and postprandial circadian timepoints. Lipidomics analysis revealed significant temporal lipid metabolism, where GR disruption results in impaired regulation of specific triglycerides, nonesterified fatty acids, and sphingolipids. This correlates with increased number and size of lipid droplets and mildly reduced mitochondrial respiration, most noticeably in the postprandial phase. Proteomics and transcriptomics analyses suggest that dysregulated lipid metabolism originates from pronounced induced expression of enzymes involved in fatty acid synthesis, β-oxidation, and sphingolipid metabolism. Integration of GR cistromic data suggests that induced gene expression is a result of regulatory actions secondary to direct GR effects on gene transcription. [ABSTRACT FROM AUTHOR]
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- 2023
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27. Effect of Simvastatin Treatment on Mitochondrial Function and Inflammatory Status of Human White Adipose Tissue.
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Christensen, Ida Bager, Blom, Ida, Dohlmann, Tine Lovsø, Finger, Fabian, Helge, Jørn W., Gerhart-Hines, Zachary, Dela, Flemming, and Larsen, Steen
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SIMVASTATIN ,MITOCHONDRIAL DNA ,ADIPOSE tissues - Abstract
Background: Statin therapy has shown pleiotropic effects affecting both mitochondrial function and inflammatory status. However, few studies have investigated the concurrent effects of statin exposure on mitochondrial function and inflammatory status in human subcutaneous white adipose tissue. Objectives: In a cross-sectional study, we investigated the effects of simvastatin on mitochondrial function and inflammatory status in subcutaneous white adipose tissue of 55 human participants: 38 patients (19 females/19 males) in primary prevention with simvastatin (> 40 mg/d, > 3 mo) and 17 controls (9 females/8 males) with elevated plasma cholesterol. The 2 groups were matched on age, body mass index, and maximal oxygen consumption. Methods: Anthropometrics and fasting biochemical characteristics were measured. Mitochondrial respiratory capacity was assessed in white adipose tissue by high-resolution respirometry. Subcutaneous white adipose tissue expression of the inflammatory markers IL-6, chemokine (C-C motif) ligand 2 (CCL2), CCL-5, tumor necrosis factor-α, IL-10, and IL-4 was analyzed by quantitative PCR. Results: Simvastatin-treated patients showed lower plasma cholesterol (P < .0001), low-density lipoprotein (P < .0001), and triglyceride levels (P = .0116) than controls. Simvastatin-treated patients had a lower oxidative phosphorylation capacity of mitochondrial complex II (P = .0001 when normalized to wet weight, P < .0001 when normalized to citrate synthase activity [intrinsic]), and a lower intrinsic mitochondrial electron transport system capacity (P = .0004). Simvastatin-treated patients showed higher IL-6 expression than controls (P = .0202). Conclusion: Simvastatin treatment was linked to mitochondrial respiratory capacity in human subcutaneous white adipose tissue, but no clear link was found between statin exposure, respiratory changes, and inflammatory status of adipose tissue. [ABSTRACT FROM AUTHOR]
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- 2023
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28. The Effect of Exercise Training on Muscle Coenzyme Q10 in Symptomatic and Asymptomatic Statin Users
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Allard, Neeltje A.E., Orlando, Patrick, Janssen, Lando, Larsen, Steen, Tiano, Luca, Hopman, Maria T.E., and Timmers, Silvie
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- 2023
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29. LIFESTAT – Living with statins : An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction
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CHRISTENSEN, CHRISTA LYKKE, HELGE, JØRN WULFF, KRASNIK, ALLAN, KRIEGBAUM, MARGIT, RASMUSSEN, LENE JUEL, HICKSON, IAN D., LIISBERG, KASPER BERING, OXLUND, BJARKE, BRUUN, BIRGITTE, LAU, SOFIE ROSENLUND, OLSEN, MARIA NATHALIE ANGLEYS, ANDERSEN, JOHN SAHL, HELTBERG, ANDREAS SØNDERGAARD, KUHLMAN, ANJA BIRK, MORVILLE, THOMAS HOFFMANN, DOHLMANN, TINE LOVSØ, LARSEN, STEEN, and DELA, FLEMMING
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- 2016
30. Thoughts on Space
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Larsen, Steen Nepper
- Abstract
bidrag til Kaspar Bonnéns bog: "The Past Will Never Leave You" (med udvalgte kunstneriske arbejder; bidraget forefindes også på dansk: "Tanker om rum")
- Published
- 2023
31. Digitalisering af forskning og undervisning på DTU Kemiteknik
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Dreyer, Jochen A. H., N. Jones, Mark, Kager, Julian, Larsen, Steen, Woodley, John M., Dam-Johansen, Kim, and Huusom, Jakob K.
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Digitalisering er et af de tre hovedmål i Danmarks Tekniske Universitets (DTU) strategi 2020-2025 og er derfor også et vigtigt fokusområde på DTU Kemiteknik (DTU KT).
- Published
- 2023
32. Aerobic Exercise Performance and Muscle Strength in Statin Users—The LIFESTAT Study
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MORVILLE, THOMAS, DOHLMANN, TINE LOVSØ, KUHLMAN, ANJA BIRK, SAHL, RONNI EG, KRIEGBAUM, MARGIT, LARSEN, STEEN, DELA, FLEMMING, and HELGE, JØRN WULFF
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- 2019
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33. Energy expenditure and intensity of ritual jumping–dancing in male Maasai.
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Christensen, Dirk L., Westgate, Kate, Griffiths, Lewis, Sironga, Joseph, Maro, Venance P., Helge, Jørn W., Larsen, Steen, Bygbjerg, Ib C., Ramaiya, Kaushik L., Jensen, Jorgen, and Brage, Soren
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RITES & ceremonies ,PHYSICAL activity ,RITUAL ,CARDIOPULMONARY fitness ,HEART beat - Abstract
Objectives: Traditional jumping–dance rituals performed by Maasai men involve prolonged physical exertion that may contribute significantly to overall physical activity level. We aimed to objectively quantify the metabolic intensity of jumping–dance activity and assess associations with habitual physical activity and cardiorespiratory fitness (CRF). Methods: Twenty Maasai men (18–37 years) from rural Tanzania volunteered to participate in the study. Habitual physical activity was monitored using combined heart rate (HR) and movement sensing over 3 days, and jumping–dance engagement was self‐reported. A 1‐h jumping–dance session resembling a traditional ritual was organized, during which participants' vertical acceleration and HR were monitored. An incremental, submaximal 8‐min step test was performed to calibrate HR to physical activity energy expenditure (PAEE) and assess CRF. Results: Mean (range) habitual PAEE was 60 (37–116) kJ day−1 kg−1, and CRF was 43 (32–54) mL O2 min−1 kg−1. The jumping–dance activity was performed at an absolute HR of 122 (83–169) beats·min−1, and PAEE of 283 (84–484) J min−1 kg−1 or 42 (18–75)% when expressed relative to CRF. The total PAEE for the session was 17 (range 5–29) kJ kg−1, ~28% of the daily total. Self‐reported engagement in habitual jumping–dance frequency was 3.8 (1–7) sessions/week, with a total duration of 2.1 (0.5–6.0) h/session. Conclusions: Intensity during traditional jumping–dance activity was moderate, but on average sevenfold higher than habitual physical activity. These rituals are common, and can make a substantial contribution to overall physical activity in Maasai men, and thus be promoted as a culture‐specific activity to increase energy expenditure and maintain good health in this population. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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34. Peripheral blood mononuclear cells exhibit increased mitochondrial respiration after adjuvant chemo‐ and radiotherapy for early breast cancer.
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Christensen, Ida Bager, Abrahamsen, Marie‐Louise, Ribas, Lucas, Buch‐Larsen, Kristian, Marina, Djordje, Andersson, Michael, Larsen, Steen, Schwarz, Peter, Dela, Flemming, and Gillberg, Linn
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MONONUCLEAR leukocytes ,OXYGEN consumption ,RESPIRATION ,MITOCHONDRIA ,BREAST cancer ,MITOCHONDRIAL DNA - Abstract
Background: Adjuvant chemo‐ and radiotherapy cause cellular damage to tumorous and healthy dividing cells. Chemotherapy has been shown to cause mitochondrial respiratory dysfunction in non‐tumorous tissues, but the effects on human peripheral blood mononuclear cells (PBMCs) remain unknown. Aim: We aimed to investigate mitochondrial respiration of PBMCs before and after adjuvant chemo‐ and radiotherapy in postmenopausal patients with early breast cancer (EBC) and relate these to metabolic parameters of the patients. Methods: Twenty‐three postmenopausal women diagnosed with EBC were examined before and shortly after chemotherapy with (n = 18) or without (n = 5) radiotherapy. Respiration (O2 flux per million PBMCs) was assessed by high‐resolution respirometry of intact and permeabilized PBMCs. Clinical metabolic characteristics and mitochondrial DNA (mtDNA) content of PBMCs (mtDN relative to nuclear DNA) were furthermore assessed. Results: Respiration of intact and permeabilized PBMCs from EBC patients significantly increased with adjuvant chemo‐ and radiotherapy (p = 6 × 10−5 and p = 1 × 10−7, respectively). The oxygen flux attributed to specific mitochondrial complexes and respiratory states increased by 17–43% compared to before therapy initiation. Similarly, PBMC mtDNA content increased by 40% (p = 0.002). Leukocytes (p = 0.0001), hemoglobin (p = 0.0003), and HDL cholesterol (p = 0.003) concentrations decreased whereas triglyceride (p = 0.01) and LDL (p = 0.02) concentrations increased after treatment suggesting a worsened metabolic state. None of the metabolic parameters or the mtDNA content of PBMCs correlated significantly with PBMC respiration. Conclusion: This study shows that mitochondrial respiration and mtDNA content in circulating PBMCs increase after adjuvant chemo‐ and radiotherapy in postmenopausal patients with EBC. Besides the increased mtDNA content, a shift in PBMC subpopulation proportions towards cells relying on oxidative phosphorylation, who may be less sensitive to chemotherapy, might influence the increased mitochondrial respiration observed iafter chemotherapy. [ABSTRACT FROM AUTHOR]
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- 2023
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35. Adenosine monophosphate‐activated protein kinase is elevated in human cachectic muscle and prevents cancer‐induced metabolic dysfunction in mice.
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Raun, Steffen H., Ali, Mona S., Han, Xiuqing, Henríquez‐Olguín, Carlos, Pham, T.C. Phung, Meneses‐Valdés, Roberto, Knudsen, Jonas R., Willemsen, Anna C.H., Larsen, Steen, Jensen, Thomas E., Langen, Ramon, and Sylow, Lykke
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- 2023
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36. In vivo toxicity of cationic micelles and liposomes
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Knudsen, Kristina Bram, Northeved, Helle, Kumar EK, Pramod, Permin, Anders, Gjetting, Torben, Andresen, Thomas L., Larsen, Steen, Wegener, Karen Malene, Lykkesfeldt, Jens, Jantzen, Kim, Loft, Steffen, Møller, Peter, and Roursgaard, Martin
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- 2015
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37. The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study
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Asping, Magnus, Stride, Nis, Søgaard, Ditte, Dohlmann, Tine Lovsø, Helge, Jørn W., Dela, Flemming, and Larsen, Steen
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- 2017
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38. Evaluation fever and evidence hunting:Contribution to 'Research Literacy in Education', a special issue of P & P, ed. by Ass. Prof. Andreas Eriksen (Oslo-MET) et al
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Larsen, Steen Nepper
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Contribution til special issue: "Research Literacy in Education" of P & P, Spring 2023, ed. by Andreas Eriksen (Oslo-Met) et al.
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- 2022
39. Supplementary material
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Larsen, Steen
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supplementary material
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- 2022
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40. A Scoping Review Investigating the "Gene-Dosage Theory" of Mitochondrial DNA in the Healthy Skeletal Muscle.
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Pedersen, Zandra Overgaard, Pedersen, Britt Staevnsbo, Larsen, Steen, and Dysgaard, Tina
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MITOCHONDRIAL DNA ,SKELETAL muscle ,AEROBIC exercises ,MULTIENZYME complexes ,CLINICAL trials ,ELECTRON transport - Abstract
This review provides an overview of the evidence regarding mtDNA and valid biomarkers for assessing mitochondrial adaptions. Mitochondria are small organelles that exist in almost all cells throughout the human body. As the only organelle, mitochondria contain their own DNA, mitochondrial DNA (mtDNA). mtDNA-encoded polypeptides are subunits of the enzyme complexes in the electron transport chain (ETC) that are responsible for production of ATP to the cells. mtDNA is frequently used as a biomarker for mitochondrial content, since changes in mitochondrial volume are thought to induce similar changes in mtDNA. However, some exercise studies have challenged this "gene-dosage theory", and have indicated that changes in mitochondrial content can adapt without changes in mtDNA. Thus, the aim of this scoping review was to summarize the studies that used mtDNA as a biomarker for mitochondrial adaptions and address the question as to whether changes in mitochondrial content, induce changes in mtDNA in response to aerobic exercise in the healthy skeletal muscle. The literature was searched in PubMed and Embase. Eligibility criteria included: interventional study design, aerobic exercise, mtDNA measurements reported pre- and postintervention for the healthy skeletal muscle and English language. Overall, 1585 studies were identified. Nine studies were included for analysis. Eight out of the nine studies showed proof of increased oxidative capacity, six found improvements in mitochondrial volume, content and/or improved mitochondrial enzyme activity and seven studies did not find evidence of change in mtDNA copy number. In conclusion, the findings imply that mitochondrial adaptions, as a response to aerobic exercise, can occur without a change in mtDNA copy number. [ABSTRACT FROM AUTHOR]
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- 2023
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41. Effect of regional muscle location but not adiposity on mitochondrial biogenesis-regulating proteins
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Ponce-González, Jesús Gustavo, Ara, Ignacio, Larsen, Steen, Guerra, Borja, Calbet, Jose A. L., and Helge, Jørn Wulff
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- 2016
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42. To share and 'be shared'…
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Wentzel Winther, Ida and Nepper Larsen, Steen
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shared and divorced children ,we-ness ,extended families ,siblingship ,throwntogetherness - Abstract
Many children either commute in and out of multiple households or have siblings who do so. They switch between home settings; some of them have to pack themselves and their history/ies into their luggage and move them across the country. They move between multiple households; from one set of home logics to another. They are parts of multi-local extended families and as participants in such multiple families and households share in the conditions of having to share. To a certain degree, they share their everyday lives, things, memories, places, and past and future experiences, but as the ones who move back and forth, they belong a little less to each place. They are “demanded” and “shared”. This paper focuses on children who share family and siblingship – limited to neither a single place nor family unit. Based on a phenomenological understanding, our research sheds light on how the children’s participation in different households places them in different “we-communities”, where sharing must be handled and practiced in an everyday manner. We also shed light on how “shared children” expose different patterns of commonality and divisional practices.
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- 2022
43. Choice of medium affects PBMC quantification, cell size, and downstream respiratory analysis
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Christensen, Ida Bager, Ribas, Lucas, Larsen, Steen, Dela, Flemming, and Gillberg, Linn
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High-resolution respirometry (HRR) can assess PBMC bioenergetics, but no standardized medium for PBMC preparation and HRR analysis exist. Here, we study the effect of four different media (MiR05, PBS, RPMI, Plasmax) on quantification, size, and HRR analysis (Oxygraph-O2k) of intact PBMCs. Remarkably, PBMC quantification was 21% higher in MiR05 than PBS and Plasmax, and 28% higher than in RPMI, causing O2 flux underestimation during HRR due to inherent adjustments. Moreover, smaller cell size of PBMCs and aggregation was observed in MiR05. We suggest optimization of HRR with a standardized, plasma-like medium for future HRR analysis of intact PBMCs.
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- 2022
44. Pilot Plant 4.0: A Review of Digitalization Efforts of the Chemical and Biochemical Engineering Department at the Technical University of Denmark (DTU)
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Jones, Mark Nicholas, Stevnsborg, Mads, Nielsen, Rasmus Fjordbak, Carberry, Deborah, Bagherpour, Khosrow, Mansouri, Seyed Soheil, Larsen, Steen, Gernaey, Krist V., Dreyer, Jochen, Woodley, John, Huusom, Jakob Kjøbsted, and Dam-Johansen, Kim
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- 2022
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45. Is there a Purpose of Education?
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Larsen, Steen Nepper and Hattie, John
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Pædagogisk filosofi - Abstract
Her er netadgangen:https://neu.org.uk/media/16836/view
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- 2021
46. The north wind::A critical perspective on the purposes of education
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Larsen, Steen Nepper
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Pædagogisk filosofi - Published
- 2021
47. Ceramide content is higher in type I compared to type II fibers in obesity and type 2 diabetes mellitus
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Kristensen, Ditte, Prats, Clara, Larsen, Steen, Ara, Ignacio, Dela, Flemming, and Helge, Jørn W.
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- 2013
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48. Increased Postprandial Response of Glucagon-Like Peptide-2 in Patients with Chronic Pancreatitis and Pancreatic Exocrine Insufficiency
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Hornum, Mads, Pedersen, Jan F., Larsen, Steen, Olsen, Ole, Holst, Jens J., and Knop, Filip K.
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- 2010
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49. Mitochondrial physiology: Gnaiger Erich et al ― MitoEAGLE Task Group
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Gnaiger, Erich, Aasander Frostner, Eleonor, Abdul Karim, Norwahidah, Abdel-Rahman, Engy Ali, Abumrad, Nada A, Acuna-Castroviejo, Dario, Adiele, Reginald C, Ahn, Bumsoo, Alencar, MB, Ali, Sameh S, Almeida, Angeles, Alton, Lesley, Alves, Marco G, Amati, Francesca, Amoedo, Nivea Dias, Amorim, Ricardo, Anderson, Ethan J, Andreadou, Ioanna, Antunes, Diana, Arago, Marc, Aral, Cenk, Arandarcikaite, Odeta, Arias-Reyes, Christian, Armand, Anne-Sophie, Arnould, Thierry, Avram, Vlad Florian, Axelrod, Christopher L, Bairam, Aida, Bailey, Damian M, Bajpeyi, Sudip, Bajzikova, Martina, Bakker, Barbara M, Barlow, Jonathan, Bardal, Tora, Banni, A, Bastos Sant'Anna Silva, Ana Carolina, Batterson, Philip, Battino, Maurizio, Bazil, Jason, Beard, Daniel A, Beleza, Jorge, Bednarczyk, Piotr, Bello, Fiona, Ben-Shachar, Dorit, Bento Guida, Jose Freitas, Bergdahl, Andreas, Berge, Rolf K, Bergmeister, Lisa, Bernardi, Paolo, Berridge, Michael V, Bettinazzi, Stefano, Bishop, David, Blier, Pierre U, Blindheim, Dan Filip, Boardman, Neoma T, Boetker, Hans Erik, Borchard, Sabine, Boros, Mihaly, Borsheim, Elisabet, Borras, Consuelo, Borutaite, Vilma, Botella, Javier, Bouillaud, Frederic, Bouitbir, Jamal, Boushel, Robert C, Bovard, Josh, Bravo-Sagua, Roberto, Breton, Sophie, Brown, David A, Brown, Guy C, Brown, Robert A, Brozinick, Joseph T, Buettner, Garry R, Burtscher, Johannes, Bustos, Matilde, Calabria, Elisa, Calbet, Jose A, Calzia, Enrico, Cannon, Daniel T, Cano Sanchez, Maria, Canto Alvarez, Carles, Cardinale, D, Cardoso, Luiza Helena Daltro, Carvalho, Eugenia, Casado Pinna, Marta, Cassar, Samantha, Castelo, Maria P, Castilho, Roger F, Cavalcanti-de-Albuquerque, Joao Paulo, Cecatto, Cristiane, Celen, Murat C, Cervinkova, Zuzana, Chabi, Beatrice, Chakrabarti, Lisa, Chakrabarti, Sasanka, Chaurasia, Bhagirath, Chen, Quan, Chicco, Adam J, Chinopoulos, Christos, Chowdhury, Subir K, Cizmarova, Beata, Clementi, Emilio, Coen, Paul M, Cohen, Bruce H, Coker, Robert H, Collin-Chenot, Anne, Coughlan, Melinda T, Coxito, Petro, Crisostomo, Luis, Crispim, Marcell, Crossland, Hannah, Dahdah, Norma, Dalgaard, Louise T, Dambrova, Maija, Danhelovska, Tereza, Darveau, Charles A, Darwin, Paula M, Das, Anibh M, Dash, Ranjan K, Davidova, Eliska, Davis, Michael S, Dayanidhi, Sudarshan, De Bem, Andreza Fabro, De Goede, Paul, De Palma, Clara, De Pinto, Vito, Dela, F, Dembinska-Kiec, Aldona, Detraux, Damien, Devaux, Yvan, Di Marcello, Marco, Di Paola, Floriana Jessica, Dias, Candida, Dias, Tania R, Diederich, Marc, Distefano, Giovanna, Djafarzadeh, Siamak, Doermann, Niklas, Doerrier, Carolina, Dong, Lan-Feng, Donnelly, Chris, Drahota, Zdenek, Duarte, Filipe Valente, Dubouchaud, Herve, Duchen, Michael R, Dumas, Jean-Francois, Durham, William J, Dymkowska, Dorota, Dyrstad, Sissel E, Dyson, Alex, Dzialowski, Edward M, Eaton, Simon, Ehinger, Johannes, Elmer, Eskil, Endlicher, Rene, Engin, Ayse B, Escames, Germaine, Evinova, Andrea, Ezrova, Zuzana, Falk, Marni Joy, Fell, David A, Ferdinandy, Peter, Ferko, Miroslav, Fernandez-Ortiz, Marisol, Erika, Fernandez-Vizarra, Ferreira, Julio Cesar Batista, Ferreira, Rita, Ferri, Alessandra, Festuccia, WT, Fessel, Joshua P, Filipovska, Aleksandra, Fisar, Zdenek, Fischer, Christine, Fischer, Michael, Fisher, Gordon, Fisher, Joshua J, Fontanesi, Flavia, Forbes-Hernandez, Tamara Y, Ford, Ellen, Fornaro, Mara, Fuertes Agudo, Marina, Fulton, Montana, Galina, Antonio, Galkin, Alexander, Gallee, Leon, Galli, Gina L, Gama Perez, Pau, Gan, Zhenji, Ganetzky, Rebecca, Gao, Yun, Garcia, Geovana S, Garcia-Rivas, Gerardo, Garcia-Roves, Pablo Miguel, Garcia-Souza, Luiz Felipe, Garlid, Keith D, Garrabou, Gloria, Garten, Antje, Gastaldelli, Amalia, Gayen, Jiaur, Genders, Amanda J, Genova, Maria Luisa, Giampieri, Francesca, Glatz, Jan FC, Giovarelli, Matteo, Goikoetxea Usandizaga, Naroa, Goncalo Teixeira da Silva, Rui, Goncalves, Debora Farina, Gonzalez-Armenta, Jenny L, Gonzalez-Francesqua, A, Gonzalez-Freire, Marta, Gonzalo, Hugo, Goodpaster, Bret H, Gorr, Thomas A, Gourlay, Campbell W, Grams, Bente, Granata, Cesare, Grefte, Sander, Grilo, Luis, Guarch, Meritxell Espino, Gueguen, Naig, Gumeni, Sentiljana, Haas, Clarissa B, Haavik, Jan, Hachmo, Yafit, Haendeler, Judith, Haider, Markus, Hajrulahovic, Anesa, Hamann, Andrea, Han, Jin, Han, Woo Hyun, Hancock, Chad R, Hand, Steven C, Handl, Jiri, Hansikova, Hana, Hardee, Justin P, Hargreaves, Ian P, Harper, Mary Ellen, Harrison, David K, Hassan, Hazirah, Hatakova, Zuzana, Hausenloy, Derek J, Heales, Simon JR, Heiestad, Christina, Hellgren, Kim T, Henrique, Alexandrino, Hepple, Russell T, Hernansanz-Agustin, Pablo, Hewakapuge, Sudinna, Hickey, Anthony J, Ho, Dieu Hien, Hoehn, Kyle L, Hoel, Frederik, Holland, Olivia J, Holloway, Graham P, Holzner, Lorenz, Hoppel, Charles L, Hoppeler, H, Hoppel, Florian, Houstek, Josef, Huete-Ortega, Maria, Hyrossova, Petra, Iglesias-Gonzalez, Javier, Indiveri, Cesare, Irving, Brian A, Isola, Raffaella, Iyer, Shilpa, Jackson, Christophe B, Jadiya, Pooja, Jana, Prado Fabian, Jandeleit-Dahm, K, Jang, David H, Jang, Young C, Janowska, Joanna, Jansen, Kirsten, Jansen-Duerr, Pidder, Jansone, Baiba, Jarmuszkiewicz, Wieslawa, Jaskiewicz, Anna, Jaspers, Richard T, Jedlicka, Jan, Jerome, Estaquier, Jespersen, Nichlas R, Jha, Rajan K, Joseph, Vincent, Juhasz, Laszlo, Jurczak, Michael J, Jurk, Diana, Kaambre, Tuuli, Kaczor, Jan J, Kainulainen, Heikki, Kampa, Rafal Pawel, Kandel, Sunil M, Kane, Daniel A, Kapferer, Werner, Kapnick, Senta, Kappler, Lisa, Karabatsiakis, Alexander, Karavaeva, Iuliia, Karkucinska-Wieckowska, Agnieszka, Kaur, Sarbjot, Keijer, Jaap, Keller, Markus A, Keppner, Gloria, Khamoui, Andy V, Kidere, Dita, Kilbaugh, Todd, Kim, Hyoung Kyu, Kim, Julian KS, Kimoloi, Sammy, Klepinin, Aleksandr, Klepinina, Lyudmila, Klingenspor, Martin, Klocker, Helmut, Komlódi, Timea, Kolasa, Iris, Koopman, Werner JH, Kopitar-Jerala, Natasa, Kowaltowski, Alicia J, Kozlov, Andrey V, Krajcova, Adela, Krako Jakovljevic, Nina, Kristal, Bruce S, Krycer, Jamer R, Kuang, Jujiao, Kucera, Otto, Kuka, Janis, Kwak, Hyo Bum, Kwast, Kurt, Kwon, Oh Sung, Laasmaa, Martin, Labieniec-Watala, Magdalena, Lai, Nicola, Lalic, Nebojsa M, Land, John M, Lane, Nick, Laner, Verena, Lanza, Ian R, Laouafa, Sofien, Larsen, Steen, Larsen, Terje S, Lavery, Gareth G, Lazou, Antigone, Ledo, Ana Margarida, Lee, Hong Kyu, Leeuwenburgh, Christiaan, Lehti, Maarit, Lemieux, Helene, Lenaz, Giorgio, Lerfall, Jorgen, Li, Pingan A, Li Puma, Lance, Liang, Liping, Liepins, Edgars, Lin, Chien-Te, Liu, Jiankang, Lopez, Luis C, Lucchinetti, Eliana, Ma, Tao, Macedo, Maria P, Machado, Ivo F, Maciej, Sarah, MacMillan-Crow, Lee Ann, Magalhaes, Jose, Magri, Andrea, Majtnerova, Pavlina, Makarova, Elina, Makrecka-Kuka, Marina, Malik, Afshan N, Marcouiller, Francois, Marechal, Amandine, Markova, Michaela, Markovic, Ivanka, Martin, Daniel S, Martins, Ana Dias, Martins, Joao D, Maseko, Tumisang Edward, Maull, Felicia, Mazat, Jean Pierre, McKenna, Helen T, McKenzie, Matthew, McMillan, Duncan GG, McStay, Gavin P, Menze, Michael A, Mendham, Amy, Mercer, John R, Merz, Tamara, Messina, Angela, Meszaros, Andras T, Methner, Axel, Michalak, Slawomir, Mila Guasch, Maria, Minuzzi, Luciele M, Misirkic Marjanovic, Maja, Moellering, Douglas R, Moisoi, Nicoleta, Molina, Anthony JA, Montaigne, David, Moore, Anthony L, Moore, Christy, Moreau, Kerrie, Moreira, Bruno P, Moreno-Sanchez, Rafael, Mracek, Tomas, Muccini, Anna Maria, Muntane, Jordi, Muntean, Danina M, Murray, Andrew J, Musiol, Eva, Nabben, Miranda, Nair, K Sreekumaran, Nehlin, Jan O, Nemec, Michal, Nesci, Salvatore, Neufer, P Darrell, Neuzil, Jiri, Neviere, Remi, Newsom, Sean A., Norman, Jennifer, Nozickova, Katerina, Nunes, Sara, Nuoffer, Jean-Marc, O'Brien, Kristin, O'Brien, Katie A, O'Gorman, Donal, Olgar, Yusuf, Oliveira, Ben, Oliveira, Jorge, Oliveira, Marcus F, Oliveira, Marcos Tulio, Oliveira, Pedro F, Oliveira, Paulo J, Olsen, Rolf Erik, Orynbayeva, Zulfiya, Osiewacz, Heinz D, Paez, Hector, Pak, Youngmi K, Pallotta, Maria L, Palmeira, Carlos M, Parajuli, Nirmala, Passos, Joao F, Passrugger, Manuela, Patel, Hemal H, Pavlova, Nadia, Pavlovic, Kasja, Pecina, Petr, Pedersen, Tina M, Perales, Jose Carlos, Pereira da Silva Grilo da Silva, Filomena, Pereira, Rita, Perez Valencia, Juan A, Perks, Kara L, Pesta, Dominik, Petit, Patrice X, Pettersen Nitschke, Ina Katrine, Pichaud, Nicolas, Pichler, Irene, Piel, Sarah, Pietka, Terri A, Pinho, Sonia A, Pino, Maria F, Pirkmajer, Sergej, Place, Nicolas, Plangger, Mario, Porter, Craig, Porter, Richard K, Preguica, Ines, Procaccio, Vincent, Prochownik, Edward V, Prola, Alexandre, Pulinilkunnil, Thomas, Puskarich, Michael A, Puurand, Marju, Radenkovic, Filip, Ramzan, Rabia, Rattan, Suresh IS, Reano, Simone, Reboredo, Patricia, Rees, Bernard B, Renner-Sattler, Kathrin, Rial, Eduardo, Robinson, Matthew M, Roden, Michael, Rodrigues, Ana Sofia, Rodriguez, Enrique, Rodriguez-Enriquez, Sara, Roesland, Gro Vatne, Rolo, Anabela Pinto, Ropelle, Eduardo R, Roshanravan, Baback, Rossignol, Rodrigue, Rossiter, Harry B, Rousar, Tomas, Rubelj, Ivica, Rybacka-Mossakowska, Joanna, Saada, Ann, Safaei, Zahra, Sarlak, Saharnaz, Salin, Karine, Salvadego, Desy, Sandi, Carmen, Saner, Nicholas, Santos, Diana, Sanz, Alberto, Sardao, Vilma, Sazanov, Leonid A, Scaife, Paula, Scatena, Roberto, Schartner, Melanie, Scheibye-Knudsen, Morten, Schilling, Jan M, Schlattner, Uwe, Schmitt, Sabine, Schneider Gasser, Edith Mariane, Schoenfeld, Peter, Schots, Pauke C, Schulz, Rainer, Schwarzer, Christoph, Scott, Graham R, Selman, Colin, Sendon, Pamella Marie, Shabalina, Irina G, Sharma, Pushpa, Sharma, Vipin, Shevchuk, Igor, Shirazi, Reza, Shiroma, Jonathan G, Siewiera, Karolina, Silber, Ariel M, Silva, Ana Maria, Sims, Carrie A, Singer, Dominique, Singh, Brijesh Kumar, Skolik, Robert A, Smenes, Benedikte Therese, Smith, James, Soares, Félix Alexandre Antunes, Sobotka, Ondrej, Sokolova, Inna, Solesio Torregrosa, M De la Encarnacion, Soliz, Jorge, Sonkar, Vijay K, Sova, Marina, Sowton, Alice P, Sparagna, Genevieve C, Sparks, Lauren M, Spinazzi, Marco, Stankova, Pavla, Starr, Jonathan, Stary, Creed, Stefan, Eduard, Stelfa, Gundega, Stepto, Nigel K, Stevanovic, Jelena, Stiban, Johnny, Stier, Antoine, Stocker, Roland, Storder, Julie, Sumbalova, Zuzana, Suomalainen, Wartiovaara Anu, Suravajhala, Prashanth, Svalbe, Baiba, Swerdlow, Russel H, Swiniuch, Daria, Szabo, Ildiko, Szewczyk, Adam, Szibor, Marten, Tanaka, Masashi, Tandler, Bernard, Tarnopolsky, Mark A, Tausan, Daniel, Tavernarakis, Nektarios, Tepp, Kersti, Teodoro, J, Thakkar, Himani, Thapa, Maheshwo, Thyfault, John P, Tomar, Dhanendra, Ton, Riccardo, Torp, May-Kristin, Torres-Quesada, Omar, Towheed, Atif, Treberg, Jason R, Tretter, Laszlo, Trewin, Adam J, Trifunovic, Aleksandra, Trivigno, Catherine, Tronstad, Karl Johan, Trougakos, Ioannis P, Truu, Laura, Tuncay, Erkan, Turan, Belma, Tyrrell, Daniel J, Urban, Tomas, Urner, Sofia, Valentine, Joseph Marco, Van Bergen, Nicole J, Van der Ende, Miranda, Varricchio, Frederick, Vaupel, Peter, Vella, Joanna, Vendelin, Marko, Verdaguer, IB, Vercesi, Anibal E, Vernerova, Andrea, Victor, Victor Manuel, Vieira Ligo Teixeira, Camila, Vidimce, Josif, Viel, Christian, Vieyra, Adalberto, Vilks, Karlis, Villena, Joseph A, Vincent, Vinnyfred, Vinogradov, Andrey D, Viscomi, Carlo, Vitorino, Rui Miguel Pinheiro, Vlachaki Walker, Julia, Vogt, Sebastian, Volani, Chiara, Volska, Kristine, Votion, Dominique-Marie, Vujacic-Mirski, Ksenija, Wagner, Brett A, Ward, Marie Louise, Warnsmann, Verena, Wasserman, David H, Watala, Cezary, Wei, Yau-Huei, Weinberger, Klaus M, White, Sarah, Whitfield, Jamie, Wickert, Anika, Wieckowski, Mariusz R, Wiesner, Rudolf J, Williams, Caroline M, Winwood-Smith, Hugh, Wohlgemuth, Stephanie E, Wohlwend, Martin, Wolff, Jonci Nikolai, Wrutniak-Cabello, Chantal, Wuest, Rob C I, Yokota, Takashi, Zablocki, Krzysztof, Zanon, Alessandra, Zanou, Nadege, Zaugg, Kathrin, Zaugg, Michael, Zdrazilova, Lucie, Zhang, Yong, Zhang, Yi Zhu, Zikova, Alena, Zischka, Hans, Zorzano, Antonio, Zujovic, Tijana, Zurmanova, Jitka, Zvejniece, Liga, Lagarrigue, Sylviane, Munro, Daniel, Pereira, Susana, Laranjinha, Joäo, Hecker, Matthias, Jusic, Amela, Prigione, Alessandro, Sommer, Natascha, Weissig, Volkmar, Guida, Bento, G, John G, Jones, JG, AMS - Tissue Function & Regeneration, AMS - Rehabilitation & Development, Physiology, Mito-Eagle - Evolution-Age-Gender-Lifestyle-Environment (Mito-Eagle), Oroboros Instruments, Dynamique Musculaire et Métabolisme (DMEM), Université de Montpellier (UM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Gnaiger Erich, Aasander Frostner Eleonor, Abdul Karim Norwahidah, Abdel-Rahman Engy Ali, Abumrad Nada A, Acuna-Castroviejo Dario, Adiele Reginald C, Ahn Bumsoo, Alencar Mayke Bezerra, Ali Sameh S, Almeida Angeles, Alton Lesley, Alves Marco G, Amati Francesca, Amoedo Nivea Dias, Amorim Ricardo, Anderson Ethan J, Andreadou Ioanna, Antunes Diana, Arago Marc, Aral Cenk, Arandarcikaite Odeta, Arias-Reyes Christian, Armand Anne-Sophie, Arnould Thierry, Avram Vlad F, Axelrod Christopher L, Bailey Damian M, Bairam Aida, Bajpeyi Sudip, Bajzikova Martina, Bakker Barbara M, Banni Aml, Bardal Tora, Barlow J, Bastos Sant'Anna Silva Ana Carolina, Batterson Philip M, Battino Maurizio, Bazil Jason N, Beard Daniel A, Bednarczyk Piotr, Beleza Jorge, Bello Fiona, Ben-Shachar Dorit, Bento Guida Jose Freitas, Bergdahl Andreas, Berge Rolf K, Bergmeister Lisa, Bernardi Paolo, Berridge Michael V, Bettinazzi Stefano, Bishop David J, Blier Pierre U, Blindheim Dan Filip, Boardman Neoma T, Boetker Hans Erik, Borchard Sabine, Boros Mihaly, Boersheim Elisabet, Borras Consuelo, Borutaite Vilma, Botella Javier, Bouillaud Frederic, Bouitbir Jamal, Boushel Robert C, Bovard Josh, Bravo-Sagua Roberto, Breton Sophie, Brown David A, Brown Guy C, Brown Robert Andrew, Brozinick Joseph T, Buettner Garry R, Burtscher Johannes, Bustos Matilde, Calabria Elisa, Calbet Jose AL, Calzia Enrico, Cannon Daniel T, Cano Sanchez Maria Consolacion, Canto Alvarez Carles, Cardinale Daniele A, Cardoso Luiza HD, Carvalho Eugenia, Casado Pinna Marta, Cassar Samantha, Castelo Rueda Maria Paulina, Castilho Roger F, Cavalcanti-de-Albuquerque Joao Paulo, Cecatto Cristiane, Celen Murat C, Cervinkova Zuzana, Chabi Beatrice, Chakrabarti Lisa, Chakrabarti Sasanka, Chaurasia Bhagirath, Chen Quan, Chicco Adam J, Chinopoulos Christos, Chowdhury Subir Kumar, Cizmarova Beata, Clementi Emilio, Coen Paul M, Cohen Bruce H, Coker Robert H, Collin-Chenot Anne, Coughlan Melinda T, Coxito Pedro, Crisostomo Luis, Crispim Marcell, Crossland Hannah, Dahdah Norma Ramon, Dalgaard Louise T, Dambrova Maija, Danhelovska Tereza, Darveau Charles-A, Darwin Paula M, Das Anibh Martin, Dash Ranjan K, Davidova Eliska, Davis Michael S, Dayanidhi Sudarshan, De Bem Andreza Fabro, De Goede Paul, De Palma Clara, De Pinto Vito, Dela Flemming, Dembinska-Kiec Aldona, Detraux Damian, Devaux Yvan, Di Marcello Marco, Di Paola Floriana Jessica, Dias Candida, Dias Tania R, Diederich Marc, Distefano Giovanna, Djafarzadeh Siamak, Doermann Niklas, Doerrier Carolina, Dong Lan-Feng, Donnelly Chris, Drahota Zdenek, Duarte Filipe Valente, Dubouchaud Herve, Duchen Michael R, Dumas Jean-Francois, Durham William J, Dymkowska Dorota, Dyrstad Sissel E, Dyson Alex, Dzialowski Edward M, Eaton Simon, Ehinger Johannes K, Elmer Eskil, Endlicher Rene, Engin Ayse Basak, Escames Germaine, Evinova Andrea, Ezrova Zuzana, Falk Marni J, Fell David A, Ferdinandy Peter, Ferko Miroslav, Fernandez-Ortiz Marisol, Fernandez-Vizarra Erika, Ferreira Julio Cesar B, Ferreira Rita Maria P, Ferri Alessandra, Fessel Joshua Patrick, Festuccia William T, Filipovska Aleksandra, Fisar Zdenek, Fischer Christine, Fischer Michael J, Fisher Gordon, Fisher Joshua J, Fontanesi Flavia, Forbes-Hernandez Tamara Y, Ford Ellen, Fornaro Mara, Fuertes Agudo Marina, Fulton Montana, Galina Antonio, Galkin Alexander, Gallee Leon, Galli Gina L J, Gama Perez Pau, Gan Zhenji, Ganetzky Rebecca, Gao Yun, Garcia Geovana S, Garcia-Rivas Gerardo, Garcia-Roves Pablo Miguel, Garcia-Souza Luiz F, Garlid Keith D, Garrabou Gloria, Garten Antje, Gastaldelli Amalia, Gayen Jiaur, Genders Amanda J, Genova Maria Luisa, Giampieri Francesca, Giovarelli Matteo, Glatz Jan FC, Goikoetxea Usandizaga Naroa, Goncalo Teixeira da Silva Rui, Goncalves Debora Farina, Gonzalez- Armenta Jenny L, Gonzalez-Franquesa Alba, Gonzalez-Freire Marta, Gonzalo Hugo, Goodpaster Bret H, Gorr Thomas A, Gourlay Campbell W, Grams Bente, Granata Cesare, Grefte Sander, Grilo Luis, Guarch Meritxell Espino, Gueguen Naig, Gumeni Sentiljana, Haas Clarissa, Haavik Jan, Hachmo Yafit, Haendeler Judith, Haider Markus, Hajrulahovic Anesa, Hamann Andrea, Han Jin, Han Woo Hyun, Hancock Chad R, Hand Steven C, Handl Jiri, Hansikova Hana, Hardee Justin P, Hargreaves Iain P, Harper Mary- Ellen, Harrison David K, Hassan Hazirah, Hatokova Zuzana, Hausenloy Derek J, Heales Simon JR, Hecker Matthias, Heiestad Christina, Hellgren Kim T, Henrique Alexandrino, Hepple Russell T, Hernansanz- Agustin Pablo, Hewakapuge Sudinna, Hickey Anthony J, Ho Dieu Hien, Hoehn Kyle L, Hoel Fredrik, Holland Olivia J, Holloway Graham P, Holzner Lorenz, Hoppel Charles L, Hoppel Florian, Hoppeler Hans, Houstek Josef, Huete-Ortega Maria, Hyrossova Petra, Iglesias-Gonzalez Javier, Indiveri Cesare, Irving Brian A, Isola Raffaella, Iyer Shilpa, Jackson Christopher Benjamin, Jadiya Pooja, Jana Prado Fabian, Jandeleit-Dahm Karin, Jang David H, Jang Young Charles, Janowska Joanna, Jansen Kirsten M, Jansen-Duerr Pidder, Jansone Baiba, Jarmuszkiewicz Wieslawa, Jaskiewicz Anna, Jaspers Richard T, Jedlicka Jan, Jerome Estaquier, Jespersen Nichlas Riise, Jha Rajan Kumar, Jones John G, Joseph Vincent, Juhasz Laszlo, Jurczak Michael J, Jurk Diana, Jusic Amela, Kaambre Tuuli, Kaczor Jan Jacek, Kainulainen Heikki, Kampa Rafal Pawel, Kandel Sunil Mani, Kane Daniel A, Kapferer Werner, Kapnick Senta, Kappler Lisa, Karabatsiakis Alexander, Karavaeva Iuliia, Karkucinska-Wieckowska Agnieszka, Kaur Sarbjot, Keijer Jaap, Keller Markus A, Keppner Gloria, Khamoui Andy V, Kidere Dita, Kilbaugh Todd, Kim Hyoung Kyu, Kim Julian KS, Kimoloi Sammy, Klepinin Aleksandr, Klepinina Lyudmila, Klingenspor Martin, Klocker Helmut, Kolassa Iris, Komlodi Timea, Koopman Werner JH, Kopitar-Jerala Natasa, Kowaltowski Alicia J, Kozlov Andrey V, Krajcova Adela, Krako Jakovljevic Nina, Kristal Bruce S, Krycer James R, Kuang Jujiao, Kucera Otto, Kuka Janis, Kwak Hyo Bum, Kwast Kurt E, Kwon Oh Sung, Laasmaa Martin, Labieniec-Watala Magdalena, Lagarrigue Sylviane, Lai Nicola, Lalic Nebojsa M, Land John M, Lane Nick, Laner Verena, Lanza Ian R, Laouafa Sofien, Laranjinha Joao, Larsen Steen, Larsen Terje S, Lavery Gareth G, Lazou Antigone, Ledo Ana Margarida, Lee Hong Kyu, Leeuwenburgh Christiaan, Lehti Maarit, Lemieux Helene, Lenaz Giorgio, Lerfall Joergen, Li Pingan Andy, Li Puma Lance, Liang Liping, Liepins Edgars, Lin Chien-Te, Liu Jiankang, Lopez Garcia Luis Carlos, Lucchinetti Eliana, Ma Tao, Macedo Maria Paula, Machado Ivo F, Maciej Sarah, MacMillan-Crow Lee Ann, Magalhaes Jose, Magri Andrea, Majtnerova Pavlina, Makarova Elina, Makrecka-Kuka Marina, Malik Afshan N, Marcouiller Francois, Marechal Amandine, Markova Michaela, Markovic Ivanka, Martin Daniel S, Martins Ana Dias, Martins Joao D, Maseko Tumisang Edward, Maull Felicia, Mazat Jean-Pierre, McKenna Helen T, McKenzie Matthew, McMillan Duncan GG, McStay Gavin P, Mendham Amy, Menze Michael A, Mercer John R, Merz Tamara, Messina Angela, Meszaros Andras, Methner Axel, Michalak Slawomir, Mila Guasch Maria, Minuzzi Luciele M, Misirkic Marjanovic Maja, Moellering Douglas R, Moisoi Nicoleta, Molina Anthony JA, Montaigne David, Moore Anthony L, Moore Christy, Moreau Kerrie, Moreira Bruno P, Moreno-Sanchez Rafael, Mracek Tomas, Muccini Anna Maria, Munro Daniel, Muntane Jordi, Muntean Danina M, Murray Andrew James, Musiol Eva, Nabben Miranda, Nair K Sreekumaran, Nehlin Jan O, Nemec Michal, Nesci Salvatore, Neufer P Darrell, Neuzil Jiri, Neviere Remi, Newsom Sean A, Norman Jennifer, Nozickova Katerina, Nunes Sara, Nuoffer Jean-Marc, O'Brien Kristin, O'Brien Katie A, O'Gorman Donal, Olgar Yusuf, Oliveira Ben, Oliveira Jorge, Oliveira Marcus F, Oliveira Marcos Tulio, Oliveira Pedro Fontes, Oliveira Paulo J, Olsen Rolf Erik, Orynbayeva Zulfiya, Osiewacz Heinz D, Paez Hector, Pak Youngmi Kim, Pallotta Maria Luigia, Palmeira Carlos, Parajuli Nirmala, Passos Joao F, Passrugger Manuela, Patel Hemal H, Pavlova Nadia, Pavlovic Kasja, Pecina Petr, Pedersen Tina M, Perales Jose Carles, Pereira da Silva Grilo da Silva Filomena, Pereira Rita, Pereira Susana P, Perez Valencia Juan Alberto, Perks Kara L, Pesta Dominik, Petit Patrice X, Pettersen Nitschke Ina Katrine, Pichaud Nicolas, Pichler Irene, Piel Sarah, Pietka Terri A, Pinho Sonia A, Pino Maria F, Pirkmajer Sergej, Place Nicolas, Plangger Mario, Porter Craig, Porter Richard K, Preguica Ines, Prigione Alessandro, Procaccio Vincent, Prochownik Edward V, Prola Alexandre, Pulinilkunnil Thomas, Puskarich Michael A, Puurand Marju, Radenkovic Filip, Ramzan Rabia, Rattan Suresh IS, Reano Simone, Reboredo-Rodriguez Patricia, Rees Bernard B, Renner-Sattler Kathrin, Rial Eduardo, Robinson Matthew M, Roden Michael, Rodrigues Ana Sofia, Rodriguez Enrique, Rodriguez-Enriquez Sara, Roesland Gro Vatne, Rohlena Jakub, Rolo Anabela Pinto, Ropelle Eduardo R, Roshanravan Baback, Rossignol Rodrigue, Rossiter Harry B, Rousar Tomas, Rubelj Ivica, Rybacka-Mossakowska Joanna, Saada Reisch Ann, Safaei Zahra, Salin Karine, Salvadego Desy, Sandi Carmen, Saner Nicholas, Santos Diana, Sanz Alberto, Sardao Vilma, Sarlak Saharnaz, Sazanov Leonid A, Scaife Paula, Scatena Roberto, Schartner Melanie, Scheibye-Knudsen Morten, Schilling Jan M, Schlattner Uwe, Schmitt Sabine, Schneider Gasser Edith Mariane, Schoenfeld Peter, Schots Pauke C, Schulz Rainer, Schwarzer Christoph, Scott Graham R, Selman Colin, Sendon Pamella Marie, Shabalina Irina G, Sharma Pushpa, Sharma Vipin, Shevchuk Igor, Shirazi Reza, Shiroma Jonathan G, Siewiera Karolina, Silber Ariel M, Silva Ana Maria, Sims Carrie A, Singer Dominique, Singh Brijesh Kumar, Skolik Robert A, Smenes Benedikte Therese, Smith James, Soares Felix Alexandre Antunes, Sobotka Ondrej, Sokolova Inna, Solesio Maria E, Soliz Jorge, Sommer Natascha, Sonkar Vijay K, Sova Marina, Sowton Alice P, Sparagna Genevieve C, Sparks Lauren M, Spinazzi Marco, Stankova Pavla, Starr Jonathan, Stary Creed, Stefan Eduard, Stelfa Gundega, Stepto Nigel K, Stevanovic Jelena, Stiban Johnny, Stier Antoine, Stocker Roland, Storder Julie, Sumbalova Zuzana, Suomalainen Anu, Suravajhala Prashanth, Svalbe Baiba, Swerdlow Russell H, Swiniuch Daria, Szabo Ildiko, Szewczyk Adam, Szibor Marten, Tanaka Masashi, Tandler Bernard, Tarnopolsky Mark A, Tausan Daniel, Tavernarakis Nektarios, Teodoro Joao Soeiro, Tepp Kersti, Thakkar Himani, Thapa Maheshwor, Thyfault John P, Tomar Dhanendra, Ton Riccardo, Torp May-Kristin, Torres-Quesada Omar, Towheed Atif, Treberg Jason R, Tretter Laszlo, Trewin Adam J, Trifunovic Aleksandra, Trivigno Catherine, Tronstad Karl Johan, Trougakos Ioannis P, Truu Laura, Tuncay Erkan, Turan Belma, Tyrrell Daniel J, Urban Tomas, Urner Sofia, Valentine Joseph Marco, Van Bergen Nicole J, Van der Ende Miranda, Varricchio Frederick, Vaupel Peter, Vella Joanna, Vendelin Marko, Vercesi Anibal E, Verdaguer Ignasi Bofill, Vernerova Andrea, Victor Victor Manuel, Vieira Ligo Teixeira Camila, Vidimce Josif, Viel Christian, Vieyra Adalberto, Vilks Karlis, Villena Josep A, Vincent Vinnyfred, Vinogradov Andrey D, Viscomi Carlo, Vitorino Rui Miguel Pinheiro, Vlachaki Walker Julia, Vogt Sebastian, Volani Chiara, Volska Kristine, Votion Dominique-Marie, Vujacic-Mirski Ksenija, Wagner Brett A, Ward Marie Louise, Warnsmann Verena, Wasserman David H, Watala Cezary, Wei Yau-Huei, Weinberger Klaus M, Weissig Volkmar, White Sarah Haverty, Whitfield Jamie, Wickert Anika, Wieckowski Mariusz R, Wiesner Rudolf J, Williams Caroline M, Winwood-Smith Hugh, Wohlgemuth Stephanie E, Wohlwend Martin, Wolff Jonci Nikolai, Wrutniak-Cabello Chantal, Wuest Rob CI, Yokota Takashi, Zablocki Krzysztof, Zanon Alessandra, Zanou Nadege, Zaugg Kathrin, Zaugg Michael, Zdrazilova Lucie, Zhang Yong, Zhang Yizhu, Zikova Alena, Zischka Hans, Zorzano Antonio, Zujovic Tijana, Zurmanova Jitka, Zvejniece Liga
- Subjects
uncoupling ,MitoPedia: Respiratory states, SI - The International System of Units, IUPAC, Coupling control, Mitochondrial preparations, Protonmotive force, Uncoupling, Oxidative phosphorylation, Phosphorylation efficiency, Electron transfer-pathway, LEAK-respiration, Residual oxygen consumption, Normalization of rate, Flow, Flux, Flux control ratio, Mitochondrial marker, Cell count, Oxygen ,[SDV]Life Sciences [q-bio] ,coupling control ,protonmotive force ,oxidative phosphorylation ,mitochondrial respiratory control ,State 4 ,electron transfer ,State 2 ,State 3 ,Mitochondrial physiology ,residual oxygen consumption ,flux ,normalization ,ion leak and slip compensatory state ,efficiency ,electron transfer system ,flow ,mitochondrial physiology ,oxygen ,mitochondrial preparations ,proton leak - Abstract
As the knowledge base and importance of mitochondrial physiology to evolution, health and diseaseexpands, the necessity for harmonizing the terminologyconcerning mitochondrial respiratory states and rates has become increasingly apparent. Thechemiosmotic theoryestablishes the mechanism of energy transformationandcoupling in oxidative phosphorylation. Theunifying concept of the protonmotive force providestheframeworkfordeveloping a consistent theoretical foundation ofmitochondrial physiology and bioenergetics.We followthe latest SI guidelines and those of the International Union of Pure and Applied Chemistry(IUPAC)onterminology inphysical chemistry, extended by considerationsofopen systems and thermodynamicsof irreversible processes.Theconcept-driven constructive terminology incorporates the meaning of each quantity and alignsconcepts and symbols withthe nomenclature of classicalbioenergetics. We endeavour to provide a balanced view ofmitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes.Uniform standards for evaluation of respiratory states and rates will ultimatelycontribute BEC 2020.1 doi:10.26124/bec:2020-0001.v1www.bioenergetics-communications.org3of 44to reproducibility between laboratories and thussupport the development of datarepositoriesof mitochondrial respiratory function in species, tissues, and cells.Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery.
- Published
- 2020
50. What is 'Quality' in the Use of Technology for Children with Learning Disabilities?
- Author
-
Larsen, Steen
- Abstract
Questions of "quality" in the use of technology with children with learning disabilities are discussed, focusing on the need for basic pedagogical considerations; the impact of the computer on the learning process relative to factors of learner control, motivation, feedback type, graphics, and screen design; and use of computerized speech feedback in remediating reading problems. (Author/PB)
- Published
- 1995
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