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The aim of this study was to investigate the anti-inflammatory effects and mechanism of isovitexin on ulcerative colitis mice and RAW264.7 cells. The results showed that isovitexin had strong antioxidant and anti-inflammatory effects, and could restore intestinal barrier integrity (p < 0.01). In addition, isovitexin inhibited the expression of MyD88, TLR4 and NF-κB p65 proteins. At the same time, isovitexin can inhibit the activation of MAPK/NF-κB signaling pathway in RAW264.7 cells. In conclusion, isovitexin has a protective effect on UC mice, and its improvement mechanism of UC might be related to MAPK/NF-κB signaling pathway. [ABSTRACT FROM AUTHOR]

Five new benzopyran derivatives (2–6) and a new natural product (1) were isolated from endophytic Daldinia eschscholzii in Dendrobium chrysotoxum and determined as (R)-2,3-dihydro-2,5-dihydroxy-2-methylchromen-4-one (1), (2R, 4S)-2,3-dihydro-2-methyl-benzopyran-4,5-diol (2), (R)-3-methoxyl-1-(2,6-dihydroxy phenyl)-butan-1-one (3), 7-O-α-d-ribosyl-5-hydroxy-2-methyl-4H-chromen-4-one (4), 7-O-α-d-ribosyl-2,3-dihydro-5-hydroxy-2-methyl-chromen-4-one (5), daldinium A (6). These compounds were evaluated for their antimicrobial activity, anti-acetylcholinesterase, nitric oxide inhibition, anticoagulant, photodynamic antimicrobial activities and glucose uptake of adipocytes. Some compounds showed photoactive antimicrobial activities and glucose uptake stimulating activities. [ABSTRACT FROM AUTHOR]

Based on the local energy Internet system project of State Grid Customer Service Center Northern Park, this paper introduces the general idea and system integration of local energy Internet design. In view of the system integration technology, this paper explores and studies the local energy Internet from the three aspects, namely planning and terminal access integration, equipment and system integration, system and system integration. It is found out that the integration technology can effectively gather energy sources and data to realize efficient integration between the energy flow and the data flow. [ABSTRACT FROM AUTHOR]

Two new cyclic tetrapeptides, cyclo( l-Val- l-Leu- l-Val- l-Ile) ( 1) and cyclo( l-Leu- l-Leu- l-Ala- l-Ala) ( 2), and 15 known compounds, cyclo(Gly- l-Leu-Gly- l-Leu) ( 3), cyclo( l-Ser- l-Phe) ( 4), cyclo( l-Leu- l-Ile) ( 5), cyclo( l-Tyr- l-Phe) ( 6), cyclo(Gly- l-Trp) ( 7), cyclo( l-Leu- l-Tyr) ( 8), cyclo(Gly- l-Phe) ( 9), cyclo( l-Phe- trans-4-hydroxy- l-Pro) ( 10), cyclo( l-Leu- l-Leu) ( 11), cyclo( l-Val- l-Phe) ( 12), cyclo( l-Val- l-Leu) ( 13), cyclo( l-Ile- l-Ile) ( 14), cyclo( l-Tyr- l-Tyr) ( 15), turnagainolide A ( 16), and bacimethrin ( 17) were isolated from the fermentation broth of Streptomyces rutgersensis T009 obtained from Elaphodus davidianus excrement. Their structures were identified on the basis of spectroscopic analysis. Meanwhile, the absolute configurations of the amino acid residues of compounds 1 and 2 were determined by advanced Marfey method. Compound 3 was obtained from a natural source for the first time. The X-ray single crystal diffraction data of bacimethrin ( 17) were also reported for the first time. Compounds 1 - 17 exhibited no antimicrobial activities with the MICs > 100 μg/ml. [ABSTRACT FROM AUTHOR]

Two new cyclic tetrapeptides (I) and (II) are isolated from the fermentation broth of Streptomyces rutgersensis T009 obtained from Elaphodus davidianus excrement together with 15 known compounds. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate the anti-inflammatory effects and mechanism of isovitexin on ulcerative colitis mice and RAW264.7 cells. The results showed that isovitexin had strong antioxidant and anti-inflammatory effects, and could restore intestinal barrier integrity ( p  < 0.01). In addition, isovitexin inhibited the expression of MyD88, TLR4 and NF- κ B p65 proteins. At the same time, isovitexin can inhibit the activation of MAPK/NF- κ B signaling pathway in RAW264.7 cells. In conclusion, isovitexin has a protective effect on UC mice, and its improvement mechanism of UC might be related to MAPK/NF- κ B signaling pathway.

Stachybotrys sp. PH30583 cultured in liquid medium only led to one structure type of novel isochroman dimers. Using the one strain-many compounds strategy, the reinvestigation of the metabolites from Stachybotrys sp. PH30583 cultured in rice solid medium led to the isolation of four triprenyl phenols, including two new bisabosquals and two known phenylspirodrimanes. Nitrobisabosquals A and B ( 1 and 2 ) are the first case of pyrrolidone-bisabosquals reported in literature. Totally different compounds were isolated using rice solid medium, compared with those isolated using liquid medium, so that rice solid medium presents a key factor in the production of triprenyl phenols. Compound 1 exhibited cytotoxicity against tumor cells, A-549, HL-60, MCF-7 SMMC-7721, and SW480, as well as weak anticoagulant activity with activated partial thromboplastin time (APTT) of 32.1 ± 0.17 s ( p < 0.05 vs. Con.) at a concentration of 5 mM. Triprenyl phenol metabolites could be used as chemotaxonomic markers for Stachybotrys .