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2. Correction: Electrophysiology lab efficiency comparison between cryoballoon and point-by-point radiofrequency ablation: a German sub-analysis of the FREEZE Cohort study

Author

Metzner, Andreas, Straube, Florian, Tilz, Roland R., Kuniss, Malte, Noelker, Georg, Tebbenjohanns, Juergen, Andresen, Dietrich, Wieneke, Heinrich, Stellbrink, Christoph, Franke, Jennifer, Dorwarth, Uwe, Carion, Phuong Lien, Holbrook, Reece, Hochadel, Matthias, Senges, Jochen, Hoffmann, Ellen, and Kuck, Karl-Heinz

Published
2023
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3. Electrophysiology lab efficiency comparison between cryoballoon and point-by-point radiofrequency ablation: a German sub-analysis of the FREEZE Cohort study

Author

Metzner, Andreas, Straube, Florian, Tilz, Roland R., Kuniss, Malte, Noelker, Georg, Tebbenjohanns, Juergen, Andresen, Dietrich, Wieneke, Heinrich, Stellbrink, Christoph, Franke, Jennifer, Dorwarth, Uwe, Carion, Phuong Lien, Holbrook, Reece, Hochadel, Matthias, Senges, Jochen, Hoffmann, Ellen, and Kuck, Karl-Heinz

Published
2023
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6. Patterns of oral anticoagulant use and outcomes in Asian patients with atrial fibrillation: a post-hoc analysis from the GLORIA-AF Registry

Author

Abban, Dzifa Wosornu, Abdul, Nasser, Abud, Atilio Marcelo, Adams, Fran, Addala, Srinivas, Adragão, Pedro, Ageno, Walter, Aggarwal, Rajesh, Agosti, Sergio, Agostoni, Piergiuseppe, Aguilar, Francisco, Linares, Julio Aguilar, Aguinaga, Luis, Ahmed, Jameel, Aiello, Allessandro, Ainsworth, Paul, Aiub, Jorge Roberto, Al-Dallow, Raed, Alderson, Lisa, Aldrete Velasco, Jorge Antonio, Alexopoulos, Dimitrios, Manterola, Fernando Alfonso, Aliyar, Pareed, Alonso, David, Alves da Costa, Fernando Augusto, Amado, José, Amara, Walid, Amelot, Mathieu, Amjadi, Nima, Ammirati, Fabrizio, Andrade, Marianna, Andrawis, Nabil, Annoni, Giorgio, Ansalone, Gerardo, Ariani, M.Kevin, Arias, Juan Carlos, Armero, Sébastien, Arora, Chander, Aslam, Muhammad Shakil, Asselman, M., Audouin, Philippe, Augenbraun, Charles, Aydin, S., Ayryanova, Ivaneta, Aziz, Emad, Backes, Luciano Marcelo, Badings, E., Bagni, Ermentina, Baker, Seth H., Bala, Richard, Baldi, Antonio, Bando, Shigenobu, Banerjee, Subhash, Bank, Alan, Esquivias, Gonzalo Barón, Barr, Craig, Bartlett, Maria, Kes, Vanja Basic, Baula, Giovanni, Behrens, Steffen, Bell, Alan, Benedetti, Raffaella, Mazuecos, Juan Benezet, Benhalima, Bouziane, Bergler-Klein, Jutta, Berneau, Jean-Baptiste, Bernstein, Richard A., Berrospi, Percy, Berti, Sergio, Berz, Andrea, Best, Elizabeth, Bettencourt, Paulo, Betzu, Robert, Bhagwat, Ravi, Bhatta, Luna, Biscione, Francesco, Bisignani, Giovanni, Black, Toby, Bloch, Michael J., Bloom, Stephen, Blumberg, Edwin, Bo, Mario, Bøhmer, Ellen, Bollmann, Andreas, Bongiorni, Maria Grazia, Boriani, Giuseppe, Boswijk, D.J., Bott, Jochen, Bottacchi, Edo, Kalan, Marica Bracic, Bradman, Drew, Brautigam, Donald, Breton, Nicolas, Brouwers, P.J.A.M., Browne, Kevin, Cortada, Jordi Bruguera, Bruni, A., Brunschwig, Claude, Buathier, Hervé, Buhl, Aurélie, Bullinga, John, Cabrera, Jose Walter, Caccavo, Alberto, Cai, Shanglang, Caine, Sarah, Calò, Leonardo, Calvi, Valeria, Sánchez, Mauricio Camarillo, Candeias, Rui, Capuano, Vincenzo, Capucci, Alessandro, Caputo, Ronald, Rizo, Tatiana Cárdenas, Cardona, Francisco, Carlos da Costa Darrieux, Francisco, Duarte Vera, Yan Carlos, Carolei, Antonio, Carreño, Susana, Carvalho, Paula, Cary, Susanna, Casu, Gavino, Cavallini, Claudio, Cayla, Guillaume, Celentano, Aldo, Cha, Tae-Joon, Cha, Kwang Soo, Chae, Jei Keon, Chalamidas, Kathrine, Challappa, Krishnan, Chand, Sunil Prakash, Chandrashekar, Harinath, Chartier, Ludovic, Chatterjee, Kausik, Chavez Ayala, Carlos Antero, Cheema, Aamir, Cheema, Amjad, Chen, Lin, Chen, Shih-Ann, Chen, Jyh Hong, Chiang, Fu-Tien, Chiarella, Francesco, Chih-Chan, Lin, Cho, Yong Keun, Choi, Jong-Il, Choi, Dong Ju, Chouinard, Guy, Hoi-Fan Chow, Danny, Chrysos, Dimitrios, Chumakova, Galina, José Roberto, Eduardo Julián, Valenzuela, Chuquiure, Nica, Nicoleta Cindea, Cislowski, David J., Clay, Anthony, Clifford, Piers, Cohen, Andrew, Cohen, Michael, Cohen, Serge, Colivicchi, Furio, Collins, Ronan, Colonna, Paolo, Compton, Steve, Connolly, Derek, Conti, Alberto, Buenostro, Gabriel Contreras, Coodley, Gregg, Cooper, Martin, Coronel, Julian, Corso, Giovanni, Sales, Juan Cosín, Cottin, Yves, Covalesky, John, Cracan, Aurel, Crea, Filippo, Crean, Peter, Crenshaw, James, Cullen, Tina, Darius, Harald, Dary, Patrick, Dascotte, Olivier, Dauber, Ira, Davalos, Vicente, Davies, Ruth, Davis, Gershan, Davy, Jean-Marc, Dayer, Mark, De Biasio, Marzia, De Bonis, Silvana, De Caterina, Raffaele, De Franceschi, Teresiano, de Groot, J.R., De Horta, José, De La Briolle, Axel, Topete, Gilberto de la Pena, Vicenzo de Paola, Angelo Amato, de Souza, Weimar, de Veer, A., De Wolf, Luc, Decoulx, Eric, Deepak, Sasalu, Defaye, Pascal, Del-Carpio Munoz, Freddy, Brkljacic, Diana Delic, Deumite, N. Joseph, Di Legge, Silvia, Diemberger, Igor, Dietz, Denise, Dionísio, Pedro, Dong, Qiang, Rossi dos Santos, Fabio, Dotcheva, Elena, Doukky, Rami, D'Souza, Anthony, Dubrey, Simon, Ducrocq, Xavier, Dupljakov, Dmitry, Duque, Mauricio, Dutta, Dipankar, Duvilla, Nathalie, Duygun, A., Dziewas, Rainer, Eaton, Charles B., Eaves, William, Ebels-Tuinbeek; Clifford Ehrlich, L.A., Eichinger-Hasenauer, Sabine, Eisenberg, Steven J., El Jabali, Adnan, El Shahawy, Mahfouz, Hernandes, Mauro Esteves, Izal, Ana Etxeberria, Evonich, Rudolph, III, Evseeva, Oksana, Ezhov, Andrey, Fahmy, Raed, Fang, Quan, Farsad, Ramin, Fauchier, Laurent, Favale, Stefano, Fayard, Maxime, Fedele, Jose Luis, Fedele, Francesco, Fedorishina, Olga, Fera, Steven R., Gomes Ferreira, Luis Gustavo, Ferreira, Jorge, Ferri, Claudio, Ferrier, Anna, Ferro, Hugo, Finsen, Alexandra, First, Brian, Fischer, Stuart, Fonseca, Catarina, Almeida, Luísa Fonseca, Forman, Steven, Frandsen, Brad, French, William, Friedman, Keith, Friese, Athena, Fruntelata, Ana Gabriela, Fujii, Shigeru, Fumagalli, Stefano, Fundamenski, Marta, Furukawa, Yutaka, Gabelmann, Matthias, Gabra, Nashwa, Gadsbøll, Niels, Galinier, Michel, Gammelgaard, Anders, Ganeshkumar, Priya, Gans, Christopher, Quintana, Antonio Garcia, Gartenlaub, Olivier, Gaspardone, Achille, Genz, Conrad, Georger, Frédéric, Georges, Jean-Louis, Georgeson, Steven, Giedrimas, Evaldas, Gierba, Mariusz, Ortega, Ignacio Gil, Gillespie, Eve, Giniger, Alberto, Giudici, Michael C., Gkotsis, Alexandros, Glotzer, Taya V., Gmehling, Joachim, Gniot, Jacek, Goethals, Peter, Goldbarg, Seth, Goldberg, Ronald, Goldmann, Britta, Golitsyn, Sergey, Gómez, Silvia, Mesa, Juan Gomez, Gonzalez, Vicente Bertomeu, Gonzalez Hermosillo, Jesus Antonio, González López, Víctor Manuel, Gorka, Hervé, Gornick, Charles, Gorog, Diana, Gottipaty, Venkat, Goube, Pascal, Goudevenos, Ioannis, Graham, Brett, Greer, G. Stephen, Gremmler, Uwe, Grena, Paul G., Grond, Martin, Gronda, Edoardo, Grönefeld, Gerian, Gu, Xiang, Torres Torres, Ivett Guadalupe, Guardigli, Gabriele, Guevara, Carolina, Guignier, Alexandre, Gulizia, Michele, Gumbley, Michael, Günther, Albrecht, Ha, Andrew, Hahalis, Georgios, Hakas, Joseph, Hall, Christian, Han, Bing, Han, Seongwook, Hargrove, Joe, Hargroves, David, Harris, Kenneth B., Haruna, Tetsuya, Hayek, Emil, Healey, Jeff, Hearne, Steven, Heffernan, Michael, Heggelund, Geir, Heijmeriks, J.A., Hemels, Maarten, Hendriks, I., Henein, Sam, Her, Sung-Ho, Hermany, Paul, Hernández Del Río, Jorge Eduardo, Higashino, Yorihiko, Hill, Michael, Hisadome, Tetsuo, Hishida, Eiji, Hoffer, Etienne, Hoghton, Matthew, Hong, Kui, Hong, Suk keun, Horbach, Stevie, Horiuchi, Masataka, Hou, Yinglong, Hsing, Jeff, Huang, Chi-Hung, Huckins, David, Hughes, kathy, Huizinga, A., Hulsman, E.L., Hung, Kuo-Chun, Hwang, Gyo-Seung, Ikpoh, Margaret, Imberti, Davide, Ince, Hüseyin, Indolfi, Ciro, Inoue, Shujiro, Irles, Didier, Iseki, Harukazu, Israel, C. Noah, Iteld, Bruce, Iyer, Venkat, Jackson-Voyzey, Ewart, Jaffrani, Naseem, Jäger, Frank, James, Martin, Jang, Sung-Won, Jaramillo, Nicolas, Jarmukli, Nabil, Jeanfreau, Robert J., Jenkins, Ronald D., Sánchez, Carlos Jerjes, Jimenez, Javier, Jobe, Robert, Joen-Jakobsen, Tomas, Jones, Nicholas, Moura Jorge, Jose Carlos, Jouve, Bernard, Jung, Byung Chun, Jung, Kyung Tae, Jung, Werner, Kachkovskiy, Mikhail, Kafkala, Krystallenia, Kalinina, Larisa, Kallmünzer, Bernd, Kamali, Farzan, Kamo, Takehiro, Kampus, Priit, Kashou, Hisham, Kastrup, Andreas, Katsivas, Apostolos, Kaufman, Elizabeth, Kawai, Kazuya, Kawajiri, Kenji, Kazmierski, John F., Keeling, P., Kerr Saraiva, José Francisco, Ketova, Galina, Khaira, Ajit Singh, Khripun, Aleksey, Kim, Doo-Il, Kim, Young Hoon, Kim, Nam Ho, Kim, Dae Kyeong, Kim, Jeong Su, Kim, June Soo, Kim, Ki Seok, Kim, Jin bae, Kinova, Elena, Klein, Alexander, Kmetzo, James J., Kneller, G. Larsen, Knezevic, Aleksandar, Angela Koh, Su Mei, Koide, Shunichi, Kollias, Anastasios, Kooistra, J.A., Koons, Jay, Koschutnik, Martin, Kostis, William J., Kovacic, Dragan, Kowalczyk, Jacek, Koziolova, Natalya, Kraft, Peter, Kragten, Johannes A., Krantz, Mori, Krause, Lars, Krenning, B.J., Krikke, F., Kromhout, Z., Krysiak, Waldemar, Kumar, Priya, Kümler, Thomas, Kuniss, Malte, Kuo, Jen-Yuan, Küppers, Achim, Karla Kurrelmeyer, Kwak, Choong Hwan, Laboulle, Bénédicte, Labovitz, Arthur, Lai, Wen Ter, Lam, Andy, Lam, Yat Yin, Zanetti, Fernando Lanas, Landau, Charles, Landini, Giancarlo, Figueiredo, Estêvão Lanna, Larsen, Torben, Lavandier, Karine, LeBlanc, Jessica, Lee, Moon Hyoung, Lee, Chang-Hoon, Lehman, John, Leitão, Ana, Lellouche, Nicolas, Lelonek, Malgorzata, Lenarczyk, Radoslaw, Lenderink, T., González, Salvador León, Leong-Sit, Peter, Leschke, Matthias, Ley, Nicolas, Li, Zhanquan, Li, Xiaodong, Li, Weihua, Li, Xiaoming, Lichy, Christhoh, Lieber, Ira, Limon Rodriguez, Ramon Horacio, Lin, Hailong, Lip, Gregory Y.H., Liu, Feng, Liu, Hengliang, Esperon, Guillermo Llamas, Navarro, Nassip Llerena, Lo, Eric, Lokshyn, Sergiy, López, Amador, López-Sendón, José Luís, Lorga Filho, Adalberto Menezes, Lorraine, Richard S., Luengas, Carlos Alberto, Luke, Robert, Luo, Ming, Lupovitch, Steven, Lyrer, Philippe, Ma, Changsheng, Ma, Genshan, Madariaga, Irene, Maeno, Koji, Magnin, Dominique, Maid, Gustavo, Mainigi, Sumeet K., Makaritsis, Konstantinos, Malhotra, Rohit, Manning, Rickey, Manolis, Athanasios, Manrique Hurtado, Helard Andres, Mantas, Ioannis, Jattin, Fernando Manzur, Maqueda, Vicky, Marchionni, Niccolo, Ortuno, Francisco Marin, Santana, Antonio Martín, Martinez, Jorge, Maskova, Petra, Hernandez, Norberto Matadamas, Matsuda, Katsuhiro, Maurer, Tillmann, Mauro, Ciro, May, Erik, Mayer, Nolan, McClure, John, McCormack, Terry, McGarity, William, McIntyre, Hugh, McLaurin, Brent, Medina Palomino, Feliz Alvaro, Melandri, Francesco, Meno, Hiroshi, Menzies, Dhananjai, Mercader, Marco, Meyer, Christian, Meyer, Beat J., Miarka, Jacek, Mibach, Frank, Michalski, Dominik, Michel, Patrik, Chreih, Rami Mihail, Mikdadi, Ghiath, Mikus, Milan, Milicic, Davor, Militaru, Constantin, Minaie, Sedi, Minescu, Bogdan, Mintale, Iveta, Mirault, Tristan, Mirro, Michael J., Mistry, Dinesh, Miu, Nicoleta Violeta, Miyamoto, Naomasa, Moccetti, Tiziano, Mohammed, Akber, Nor, Azlisham Mohd, Mollerus, Michael, Molon, Giulio, Mondillo, Sergio, Moniz, Patrícia, Mont, Lluis, Montagud, Vicente, Montaña, Oscar, Monti, Cristina, Moretti, Luciano, Mori, Kiyoo, Moriarty, Andrew, Morka, Jacek, Moschini, Luigi, Moschos, Nikitas, Mügge, Andreas, Mulhearn, Thomas J., Muresan, Carmen, Muriago, Michela, Musial, Wlodzimierz, Musser, Carl W., Musumeci, Francesco, Nageh, Thuraia, Nakagawa, Hidemitsu, Nakamura, Yuichiro, Nakayama, Toru, Nam, Gi-Byoung, Nanna, Michele, Natarajan, Indira, Nayak, Hemal M., Naydenov, Stefan, Nazlić, Jurica, Cristian Nechita, Alexandru, Nechvatal, Libor, Negron, Sandra Adela, Neiman, James, Neuenschwander, Fernando Carvalho, Neves, David, Neykova, Anna, Miguel, Ricardo Nicolás, Nijmeh, George, Nizov, Alexey, Campos, Rodrigo Noronha, Nossan, Janko, Novikova, Tatiana, Nowalany-Kozielska, Ewa, Nsah, Emmanuel, Nunez Fragoso, Juan Carlos, Nurgalieva, Svetlana, Nuyens, Dieter, Nyvad, Ole, Odin de Los Rios Ibarra, Manuel, O'Donnell, Philip, O'Donnell, Martin, Oh, Seil, Oh, Yong Seog, Oh, Dongjin, O'Hara, Gilles, Oikonomou, Kostas, Olivares, Claudia, Oliver, Richard, Ruiz, Rafael Olvera, Olympios, Christoforos, omaszuk-Kazberuk, Anna, Asensi, Joaquín Osca, Jose, eena Padayattil, Padilla Padilla, Francisco Gerardo, Rios, Victoria Padilla, Pajes, Giuseppe, Pandey, Shekhar, Paparella, Gaetano, Paris, F., Park, Hyung Wook, Park, Jong Sung, Parthenakis, Fragkiskos, Passamonti, Enrico, Patel, Rajesh J., Patel, Jaydutt, Patel, Mehool, Patrick, Janice, Jimenez, Ricardo Pavón, Paz, Analía, Pengo, Vittorio, Pentz, William, Pérez, Beatriz, Pérez Ríos, Alma Minerva, Pérez-Cabezas, Alejandro, Perlman, Richard, Persic, Viktor, Perticone, Francesco, Peters, Terri K., Petkar, Sanjiv, Pezo, Luis Felipe, Pflücke, Christian, Pham, David N., Phillips, Roland T., Phlaum, Stephen, Pieters, Denis, Pineau, Julien, Pinter, Arnold, Pinto, Fausto, Pisters, R., Pivac, Nediljko, Pocanic, Darko, Podoleanu, Cristian, Politano, Alessandro, Poljakovic, Zdravka, Pollock, Stewart, Garcéa, Jose Polo, Poppert, Holger, Porcu, Maurizio, Reino, Antonio Pose, Prasad, Neeraj, Précoma, Dalton Bertolim, Prelle, Alessandro, Prodafikas, John, Protasov, Konstantin, Pye, Maurice, Qiu, Zhaohui, Quedillac, Jean-Michel, Raev, Dimitar, Raffo Grado, Carlos Antonio, Rahimi, Sidiqullah, Raisaro, Arturo, Rama, Bhola, Ramos, Ricardo, Ranieri, Maria, Raposo, Nuno, Rashba, Eric, Rauch-Kroehnert, Ursula, Reddy, Ramakota, Renda, Giulia, Reza, Shabbir, Ria, Luigi, Richter, Dimitrios, Rickli, Hans, Rieker, Werner, Vera, Tomas Ripolil, Ritt, Luiz Eduardo, Roberts, Douglas, Briones, Ignacio Rodriguez, Rodriguez Escudero, Aldo Edwin, Pascual, Carlos Rodríguez, Roman, Mark, Romeo, Francesco, Ronner, E., Roux, Jean-Francois, Rozkova, Nadezda, Rubacek, Miroslav, Rubalcava, Frank, Russo, Andrea M., Rutgers, Matthieu Pierre, Rybak, Karin, Said, Samir, Sakamoto, Tamotsu, Salacata, Abraham, Salem, Adrien, Bodes, Rafael Salguero, Saltzman, Marco A., Salvioni, Alessandro, Vallejo, Gregorio Sanchez, Fernández, Marcelo Sanmartín, Saporito, Wladmir Faustino, Sarikonda, Kesari, Sasaoka, Taishi, Sati, Hamdi, Savelieva, Irina, Scala, Pierre-Jean, Schellinger, Peter, Scherr, Carlos, Schmitz, Lisa, Schmitz, Karl-Heinz, Schmitz, Bettina, Schnabel, Teresa, Schnupp, Steffen, Schoeniger, Peter, Schön, Norbert, Schwimmbeck, Peter, Seamark, Clare, Searles, Greg, Seidl, Karl-Heinz, Seidman, Barry, Sek, Jaroslaw, Sekaran, Lakshmanan, Serrati, Carlo, Shah, Neerav, Shah, Vinay, Shah, Anil, Shah, Shujahat, Sharma, Vijay Kumar, Shaw, Louise, Sheikh, Khalid H., Shimizu, Naruhito, Shimomura, Hideki, Shin, Dong-Gu, Shin, Eun-Seok, Shite, Junya, Sibilio, Gerolamo, Silver, Frank, Sime, Iveta, Simmers, Tim A., Singh, Narendra, Siostrzonek, Peter, Smadja, Didier, Smith, David W., Snitman, Marcelo, Filho, Dario Sobral, Soda, Hassan, Sofley, Carl, Sokal, Adam, Oi Yan, Yannie Soo, Sotolongo, Rodolfo, Ferreira de Souza, Olga, Sparby, Jon Arne, Spinar, Jindrich, Sprigings, David, Spyropoulos, Alex C., Stakos, Dimitrios, Steinwender, Clemens, Stergiou, Georgios, Stiell, Ian, Stoddard, Marcus, Stoikov, Anastas, Streb, Witold, Styliadis, Ioannis, Su, Guohai, Su, Xi, Sudnik, Wanda, Sukles, Kai, Sun, Xiaofei, Swart, H., Szavits-Nossan, Janko, Taggeselle, Jens, Takagi, Yuichiro, Singh Takhar, Amrit Pal, Tamm, Angelika, Tanaka, Katsumi, Tanawuttiwat, Tanyanan, Tang, Sherman, Tang, Aylmer, Tarsi, Giovanni, Tassinari, Tiziana, Tayal, Ashis, Tayebjee, Muzahir, Berg, J.M. ten, Tesloianu, Dan, The, Salem H.K., Thomas, Dierk, Timsit, Serge, Tobaru, Tetsuya, Tomasik, Andrzej R., Torosoff, Mikhail, Touze, Emmanuel, Trendafilova, Elina, Tsai, W. Kevin, Tse, Hung Fat, Tsutsui, Hiroshi, Tu, Tian Ming, Tuininga, Ype, Turakhia, Minang, Turk, Samir, Turner, Wayne, Tveit, Arnljot, Tytus, Richard, Valadão, C., van Bergen, P.F.M.M., van de Borne, Philippe, van den Berg, B.J., van der Zwaan, C., Van Eck, M., Vanacker, Peter, Vasilev, Dimo, Vasilikos, Vasileios, Vasilyev, Maxim, Veerareddy, Srikar, Miño; Asok Venkataraman, Mario Vega, Verdecchia, Paolo, Versaci, Francesco, Vester, Ernst Günter, Vial, Hubert, Victory, Jason, Villamil, Alejandro, Vincent, Marc, Vlastaris, Anthony, Dahl, Jürgen vom, Vora, Kishor, Vranian, Robert B., Wakefield, Paul, Wang, Ningfu, Wang, Mingsheng, Wang, Xinhua, Wang, Feng, Wang, Tian, Warner, Alberta L., Watanabe, Kouki, Wei, Jeanne, Weimar, Christian, Weiner, Stanislav, Weinrich, Renate, Wen, Ming-Shien, Wiemer, Marcus, Wiggers, Preben, Wilke, Andreas, Williams, David, Williams, Marcus L., Witzenbichler, Bernhard, Wong, Brian, Lawrence Wong, Ka Sing, Wozakowska-Kaplon, Beata, Wu, Shulin, Wu, Richard C., Wunderlich, Silke, Wyatt, Nell, Wylie, John (Jack), Xu, Yong, Xu, Xiangdong, Yamanoue, Hiroki, Yamashita, Takeshi, Bryan Yan, Ping Yen, Yang, Tianlun, Yao, Jing, Yeh, Kuo-Ho, Yin, Wei Hsian, Yotov, Yoto, Zahn, Ralf, Zarich, Stuart, Zenin, Sergei, Zeuthen, Elisabeth Louise, Zhang, Huanyi, Zhang, Donghui, Zhang, Xingwei, Zhang, Ping, Zhang, Jun, Zhao, Shui Ping, Zhao, Yujie, Zhao, Zhichen, Zheng, Yang, Zhou, Jing, Zimmermann, Sergio, Zini, Andrea, Zizzo, Steven, Zong, Wenxia, Zukerman, L. Steven, Romiti, Giulio Francesco, Corica, Bernadette, Proietti, Marco, Mei, Davide Antonio, Frydenlund, Juliane, Bisson, Arnaud, Olshansky, Brian, Chan, Yi-Hsin, Huisman, Menno V., and Chao, Tze-Fan

Published
2023
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7. Expert opinion on design and endpoints for studies on catheter ablation of atrial fibrillation.

Author

Lewalter, Thorsten, Blomström‐Lundqvist, Carina, Lakkireddy, Dhanunjaya, Packer, Douglas, Meyer, Ralf, Kuniss, Malte, Ladwig, Karl‐H., Jilek, Clemens, Diener, Hans‐C., Boriani, Giuseppe, Turakhia, Mintu P., Schneider, Steffen, Svennberg, Emma, Albers, Bert, Andrade, Jason G., de Melis, Mirko, and Brachmann, Johannes

Subjects
MEDICAL protocols, DOCUMENTATION, PATIENT selection, RESEARCH funding, MEDICAL personnel, ABLATION techniques, CLINICAL trials, RESEARCH evaluation, EXPERIMENTAL design, ARRHYTHMIA, DISCUSSION, ATRIAL fibrillation, RESEARCH methodology, CATHETER ablation, EXPERTISE
Abstract

Introduction: Catheter ablation of atrial fibrillation (AF) is frequently studied in randomized trials, observational and registry studies. The aim of this expert opinion is to provide guidance for clinicians and industry regarding the development of future clinical studies on catheter ablation of AF, implement lessons learned from previous studies, and promote a higher degree of consistency across studies. Background: Studies on catheter ablation of AF may benefit from well‐described definitions of endpoints and consistent methodology and documentation of outcomes related to efficacy, safety and cost‐effectiveness. The availably of new, innovative technologies warrants further consideration about their application and impact on study design and the choice of endpoints. Moreover, recent insights gained from AF ablation studies suggest a reconsideration of some methodological aspects. Methods: A panel of clinical experts on catheter ablation of AF and designing and conducting clinical studies developed an expert opinion on the design and endpoints for studies on catheter ablation of AF. Discussions within the expert panel with the aim to reach consensus on predefined topics were based on outcomes reported in the literature and experiences from recent clinical trials. Results: A comprehensive set of recommendations is presented. Key elements include the documentation of clinical AF, medication during the study, repeated ablations and their effect on endpoint assessments, postablation blanking and the choice of rhythm‐related and other endpoints. Conclusion: This expert opinion provides guidance and promotes consistency regarding design of AF catheter ablation studies and identified aspects requiring further research to optimize study design and methodology. Recent insights from studies on catheter ablation of atrial fibrillation (AF) and the availability of new innovative technologies warrant reconsideration of methodological aspects related to study design and the choice and assessment of endpoints. This expert opinion, developed by clinical experts on catheter ablation of AF provides a comprehensive set of recommendations related to these methodological aspects. The aim of this expert opinion is to provide guidance for clinicians and industry regarding the development of clinical studies, implement lessons learned from previous studies, and promote a higher degree of consistency across studies. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Initial rhythm control with cryoballoon ablation vs drug therapy: Impact on quality of life and symptoms

Author

Pavlovic, Nikola, Chierchia, Gian-Battista, Velagic, Vedran, Hermida, Jean Sylvain, Healey, Stewart, Arena, Giuseppe, Badenco, Nicolas, Meyer, Christian, Chen, Jian, Iacopino, Saverio, Anselme, Frédéric, Dekker, Lukas, Scazzuso, Fernando, Packer, Douglas L, de Asmundis, Carlo, Pitschner, Heinz-Friedrich, Piazza, Fabio Di, Kaplon, Rachelle E, and Kuniss, Malte

Published
2021
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13. Phrenic Nerve Injury During Cryoballoon-Based Pulmonary Vein Isolation: Results of the Worldwide YETI Registry

Author

Heeger, Christian-H., Sohns, Christian, Pott, Alexander, Metzner, Andreas, Inaba, Osamu, Straube, Florian, Kuniss, Malte, Aryana, Arash, Miyazaki, Shinsuke, Cay, Serkan, Ehrlich, Joachim R., El-Battrawy, Ibrahim, Martinek, Martin, Saguner, Ardan M., Tscholl, Verena, Yalin, Kivanc, Lyan, Evgeny, Su, Wilber, Papiashvili, Giorgi, Botros, Maichel Sobhy Naguib, Gasperetti, Alessio, Proietti, Riccardo, Wissner, Erik, Scherr, Daniel, Kamioka, Masashi, Makimoto, Hisaki, Urushida, Tsuyoshi, Aksu, Tolga, Chun, Julian K.R., Aytemir, Kudret, Jędrzejczyk-Patej, Ewa, Kuck, Karl-Heinz, Dahme, Tillman, Steven, Daniel, Sommer, Philipp, and Richard Tilz, Roland

Published
2022
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19. Pulmonary Vein Isolation Followed by Biatrial Ablation of Rotational Activity in Patients with Persistent Atrial Fibrillation: Results of the Cryo-Vest Study.

Author

Weipert, Kay Felix, Hutter, Julie, Kuniss, Malte, Kahle, Patrick, Yogarajah, Joerg, Hain, Andreas, Sperzel, Johannes, Berkowitsch, Alexander, Hamm, Christian W., and Neumann, Thomas

Subjects
ATRIAL fibrillation, PULMONARY veins, CRYOSURGERY, BODY surface mapping, CATHETER ablation, ATRIAL arrhythmias
Abstract

Background and Aims: Noninvasive mapping allows the identification of patient-specific atrial rotational activity (RA) that might play a key role in the perpetuation of persistent atrial fibrillation (PsAF). So far, the impact of pulmonary vein isolation by cryoballoon (Cryo-PVI) on RA is unclear. Moreover, the long-term effect of periprocedural termination of AF during the ablation procedure is controversial. Methods: Noninvasive electrocardiographic mapping with a 252-electrode vest was performed in 42 patients with PsAF. After the first analysis, Cryo-PVI was performed. The RA was analyzed again and then targeted by radiofrequency catheter ablation. The primary clinical endpoint was periprocedural termination of AF. The secondary endpoint was freedom from any atrial arrhythmia >30 s during a 12-month follow-up. Results: In 33 patients (79%), right atrial RA was identified leading to biatrial ablation, and nine patients (21%) had left atrial RA only. Twelve patients (28.6%) converted from AF to sinus rhythm (SR) (Group A). Thirteen patients (30.9%) converted to atrial tachycardia (AT) (Group B). In 17 patients (40.5%), AF was not terminated by ablation (Group C). After a mean follow-up time of 13.8 months, 26 patients were free from AF and AT (61.9%). In terms of rhythm, control Group A (75%) and B (83.3%) showed higher success rates than Group C (33.3%) (p < 0.01). Cryo-PVI had no substantial impact on RA. Conclusions: The RA-based ablation approach showed acceptable success rates. Periprocedural termination of AF had a positive predictive impact on the outcome. No difference was observed between conversion to SR or to AT. Cryo-PVI had no impact on RA. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Impact of intracardiac echocardiography usage on the safety of cryoballoon atrial fibrillation ablation: Subanalysis of the prospective FREEZE cluster cohort study.

Author

Pongratz, Janis, Kuniss, Malte, Wu, Liqun, Tebbenjohanns, Jürgen, Nölker, Georg, Dorwarth, Uwe, Kuck, Karl‐Heinz, Jochen, Senges, Hoffmann, Ellen, and Straube, Florian

Subjects
*SURGICAL therapeutics, *CARDIAC surgery, *RELATIVE medical risk, *ATRIAL arrhythmias, *CONFIDENCE intervals, *TRANSESOPHAGEAL echocardiography, *MAJOR adverse cardiovascular events, *ATRIAL fibrillation, *CRYOSURGERY, *CATHETER ablation, *SURGICAL complications, *MANN Whitney U Test, *PATIENT readmissions, *DISEASE incidence, *RISK assessment, *CARDIAC tamponade, *COMPARATIVE studies, *FLUOROSCOPY, *SEX distribution, *DISEASE relapse, *TREATMENT effectiveness, *DESCRIPTIVE statistics, *CHI-squared test, *PULMONARY veins, *ODDS ratio, *STATISTICAL models, *DATA analysis software, *LOGISTIC regression analysis, *SECONDARY analysis, *LEFT heart atrium, *LONGITUDINAL method, *DISEASE risk factors
Abstract

Introduction: Cryoballoon ablation (CBA) aiming at pulmonary vein isolation (PVI) became a standardized atrial fibrillation (AF) ablation procedure. Life‐threatening complications like cardiac tamponade exist. Intracardiac echocardiography (ICE) usage is associated with superior safety in radiofrequency ablation. It is unclear if ICE has an impact on safety of CBA. Methods: The FREEZE Cohort (NCT01360008) subanalysis included patients undergoing "PVI only" CBA. Patients with intraprocedural transesophageal echocardiography were excluded. Group A comprises conventional, group B ICE‐guided CBA. Periprocedural results were compared. Results: From 2011 to 2016, a total of 4189 patients were enrolled, and 1906 (45.5%) were included in this subanalysis, split up in two groups (A: 1066 [55.9%], B: 840 [44.1%]). Group A was younger (60.6 ± 10.8 vs. 62.4 ± 10.5 years, p <.001), with smaller left atria (41 vs. 43 mm, p <.001), and less persistent AF (23.1 vs. 38.1%, p <.001). Procedure, left atrial, and fluoroscopy times were shorter in group A as compared to group B. Dose area product was significantly higher in group A (2911 vs. 2072 cGyxcm2, p <.001). In‐hospital major adverse cerebrovascular and cardiac event rates including two deaths in group A were not different between groups (0.5% vs. 0.1%, p =.18). The rate of total procedural (10.4% vs. 5.1%, p <.001) and major complications (3.2% vs. 1.3%, p <.001) was significantly higher in group A. Cardiac tamponade occurred significantly more frequently in group A (8 [0.8%] vs. 1 [0.1%], p =.046). Independent predictors for major complications were female sex (odds ratio [OR] 2.03, p =.03) and non‐ICE usage (OR 2.38, p =.02). No differences were observed for persistent phrenic nerve palsy, nor for groin complications. Conclusion: CBA was significantly safer and required less radiation if ICE was used, although the procedures were more complex. The risk of groin complications was not increased with ICE usage. Non‐ICE usage was the only modifiable independent predictor of major complications. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Correction to: Comparative effectiveness and safety of non-vitamin K antagonists for atrial fibrillation in clinical practice: GLORIA-AF Registry (Clinical Research in Cardiology, (2022), 111, 5, (560-573), 10.1007/s00392-022-01996-2)

Author

Lip, Gregory Y. H., Kotalczyk, Agnieszka, Teutsch, Christine, Diener, Hans-Christoph, Dubner, Sergio J., Halperin, Jonathan L., Ma, Chang-Sheng, Rothman, Kenneth J., Marler, Sabrina, Gurusamy, Venkatesh Kumar, Huisman, Menno V., Abban, Dzifa Wosornu, Aziz, Emad, Kalan, Marica Bracic, Abdul, Nasser, Backes, Luciano Marcelo, Bradman, Drew, Abud, Atilio Marcelo, Badings, E., Brautigam, Donald, Adams, Fran, Bagni, Ermentina, Breton, Nicolas, Addala, Srinivas, Baker, Seth H., Brouwers, P. J. A. M., Adragão, Pedro, Bala, Richard, Browne, Kevin, Ageno, Walter, Baldi, Antonio, Cortada, Jordi Bruguera, Aggarwal, Rajesh, Bando, Shigenobu, Bruni, A., Agosti, Sergio, Banerjee, Subhash, Brunschwig, Claude, Agostoni, Piergiuseppe, Bank, Alan, Buathier, Hervé, Aguilar, Francisco, Esquivias, Gonzalo Barón, Buhl, Aurélie, Linares, Julio Aguilar, Barr, Craig, Bullinga, John, Aguinaga, Luis, Bartlett, Maria, Cabrera, Jose Walter, Ahmed, Jameel, Basic Kes, Vanja, Caccavo, Alberto, Aiello, Allessandro, Baula, Giovanni, Cai, Shanglang, Ainsworth, Paul, Behrens, Steffen, Caine, Sarah, Aiub, Jorge Roberto, Bell, Alan, Calò, Leonardo, Al-Dallow, Raed, Benedetti, Raffaella, Calvi, Valeria, Alderson, Lisa, Mazuecos, Juan Benezet, Sánchez, Mauricio Camarillo, Velasco, Jorge Antonio Aldrete, Benhalima, Bouziane, Candeias, Rui, Alexopoulos, Dimitrios, Bergler-Klein, Jutta, Capuano, Vincenzo, Manterola, Fernando Alfonso, Berneau, Jean-Baptiste, Capucci, Alessandro, Aliyar, Pareed, Bernstein, Richard A., Caputo, Ronald, Alonso, David, Berrospi, Percy, Rizo, Tatiana C. rdenas, da Costa, Fernando Augusto Alves, Berti, Sergio, Cardona, Francisco, Amado, José, Berz, Andrea, da Costa Darrieux, Francisco Carlos, Amara, Walid, Best, Elizabeth, Vera, Yan Carlos Duarte, Amelot, Mathieu, Bettencourt, Paulo, Carolei, Antonio, Amjadi, Nima, Betzu, Robert, Carreño, Susana, Ammirati, Fabrizio, Bhagwat, Ravi, Carvalho, Paula, Andrade, Marianna, Bhatta, Luna, Cary, Susanna, Andrawis, Nabil, Biscione, Francesco, Casu, Gavino, Annoni, Giorgio, Bisignani, Giovanni, Cavallini, Claudio, Ansalone, Gerardo, Black, Toby, Cayla, Guillaume, Ariani, M. Kevin, Bloch, Michael J., Celentano, Aldo, Arias, Juan Carlos, Bloom, Stephen, Cha, Tae-Joon, Armero, S. bastien, Blumberg, Edwin, Cha, Kwang Soo, Arora, Chander, Bo, Mario, Chae, Jei Keon, Aslam, Muhammad Shakil, Bøhmer, Ellen, Chalamidas, Kathrine, Asselman, M., Bollmann, Andreas, Challappa, Krishnan, Audouin, Philippe, Bongiorni, Maria Grazia, Chand, Sunil Prakash, Augenbraun, Charles, Boriani, Giuseppe, Chandrashekar, Harinath, Aydin, S., Boswijk, D. J., Chartier, Ludovic, Bott, Jochen, Chatterjee, Kausik, Ayryanova, Ivaneta, Bottacchi, Edo, Ayala, Carlos Antero Chavez, Cheema, Aamir, Davis, Gershan, Evonich, Rudolph, Cheema, Amjad, Davy, Jean-Marc, Evseeva, Oksana, Chen, Lin, Dayer, Mark, Ezhov, Andrey, Chen, Shih-Ann, de Biasio, Marzia, Fahmy, Raed, Chen, Jyh Hong, de Bonis, Silvana, Fang, Quan, Chiang, Fu-Tien, de Caterina, Raffaele, Farsad, Ramin, Chiarella, Francesco, de Franceschi, Teresiano, Fauchier, Laurent, Chih-Chan, Lin, de Groot, J. R., Favale, Stefano, Cho, Yong Keun, de Horta, José, Fayard, Maxime, Choi, Jong-Il, de la Briolle, Axel, Fedele, Jose Luis, Choi, Dong Ju, de la Pena Topete, Gilberto, Fedele, Francesco, Chouinard, Guy, de Paola, Angelo Amato Vicenzo, Fedorishina, Olga, Chow, Danny Hoi-Fan, de Souza, Weimar, Fera, Steven R., Chrysos, Dimitrios, de Veer, A., Ferreira, Luis Gustavo Gomes, Chumakova, Galina, de Wolf, Luc, Ferreira, Jorge, Valenzuela, Eduardo Julián José Roberto Chuquiure, Decoulx, Eric, Ferri, Claudio, Nica, Nicoleta Cindea, Deepak, Sasalu, Ferrier, Anna, Cislowski, David J., Defaye, Pascal, Ferro, Hugo, Clay, Anthony, Munoz, Freddy Del-Carpio, Finsen, Alexandra, Clifford, Piers, Brkljacic, Diana Delic, First, Brian, Cohen, Andrew, Deumite, N. Joseph, Fischer, Stuart, Cohen, Michael, di Legge, Silvia, Fonseca, Catarina, Cohen, Serge, Diemberger, Igor, Almeida, Luísa Fonseca, Colivicchi, Furio, Dietz, Denise, Forman, Steven, Collins, Ronan, Dionísio, Pedro, Frandsen, Brad, Colonna, Paolo, Dong, Qiang, French, William, Compton, Steve, dos Santos, Fabio Rossi, Friedman, Keith, Connolly, Derek, Dotcheva, Elena, Friese, Athena, Conti, Alberto, Doukky, Rami, Fruntelata, Ana Gabriela, Buenostro, Gabriel Contreras, D’Souza, Anthony, Fujii, Shigeru, Coodley, Gregg, Dubrey, Simon, Fumagalli, Stefano, Cooper, Martin, Ducrocq, Xavier, Fundamenski, Marta, Coronel, Julian, Dupljakov, Dmitry, Furukawa, Yutaka, Corso, Giovanni, Duque, Mauricio, Gabelmann, Matthias, Sales, Juan Cosín, Dutta, Dipankar, Gabra, Nashwa, Cottin, Yves, Duvilla, Nathalie, Gadsbøll, Niels, Covalesky, John, Duygun, A., Galinier, Michel, Cracan, Aurel, Dziewas, Rainer, Gammelgaard, Anders, Crea, Filippo, Eaton, Charles B., Ganeshkumar, Priya, Crean, Peter, Eaves, William, Gans, Christopher, Crenshaw, James, Ebels-Tuinbeek, L. A., Quintana, Antonio Garcia, Cullen, Tina, Ehrlich, Clifford, Gartenlaub, Olivier, Darius, Harald, Eichinger-Hasenauer, Sabine, Gaspardone, Achille, Dary, Patrick, Eisenberg, Steven J., Genz, Conrad, Dascotte, Olivier, Jabali, Adnan El, Georger, Frédéric, Dauber, Ira, Shahawy, Mahfouz El, Georges, Jean-Louis, Davalos, Vicente, Hernandes, Mauro Esteves, Georgeson, Steven, Davies, Ruth, Izal, Ana Etxeberria, Giedrimas, Evaldas, Gierba, Mariusz, Haruna, Tetsuya, Jarmukli, Nabil, Ortega, Ignacio Gil, Hayek, Emil, Jeanfreau, Robert J., Gillespie, Eve, Healey, Jeff, Jenkins, Ronald D., Giniger, Alberto, Hearne, Steven, Sánchez, Carlos Jerjes, Giudici, Michael C., Heffernan, Michael, Jimenez, Javier, Gkotsis, Alexandros, Heggelund, Geir, Jobe, Robert, Glotzer, Taya V., Heijmeriks, J. A., Joen-Jakobsen, Tomas, Gmehling, Joachim, Hemels, Maarten, Jones, Nicholas, Gniot, Jacek, Hendriks, I., Jorge, Jose Carlos Moura, Goethals, Peter, Henein, Sam, Jouve, Bernard, Goldbarg, Seth, Her, Sung-Ho, Jung, Byung Chun, Goldberg, Ronald, Hermany, Paul, Jung, Kyung Tae, Goldmann, Britta, del Río, Jorge Eduardo Hernández, Jung, Werner, Golitsyn, Sergey, Higashino, Yorihiko, Kachkovskiy, Mikhail, Gómez, Silvia, Hill, Michael, Kafkala, Krystallenia, Mesa, Juan Gomez, Hisadome, Tetsuo, Kalinina, Larisa, Gonzalez, Vicente Bertomeu, Hishida, Eiji, Kallmünzer, Bernd, Hermosillo, Jesus Antonio Gonzalez, Hoffer, Etienne, Kamali, Farzan, López, V. ctor Manuel González, Hoghton, Matthew, Kamo, Takehiro, Gorka, Hervé, Hong, Kui, Kampus, Priit, Gornick, Charles, Hong, Suk keun, Kashou, Hisham, Gorog, Diana, Horbach, Stevie, Kastrup, Andreas, Gottipaty, Venkat, Horiuchi, Masataka, Katsivas, Apostolos, Goube, Pascal, Hou, Yinglong, Kaufman, Elizabeth, Goudevenos, Ioannis, Hsing, Jeff, Kawai, Kazuya, Graham, Brett, Huang, Chi-Hung, Kawajiri, Kenji, Greer, G. Stephen, Huckins, David, Kazmierski, John F., Gremmler, Uwe, Hughes, Kathy, Keeling, P., Grena, Paul G., Huizinga, A., Saraiva, José Francisco Kerr, Grond, Martin, Hulsman, E. L., Ketova, Galina, Gronda, Edoardo, Hung, Kuo-Chun, Khaira, Ajit Singh, Grönefeld, Gerian, Hwang, Gyo-Seung, Khripun, Aleksey, Gu, Xiang, Ikpoh, Margaret, Kim, Doo-Il, Torres, Ivett Guadalupe Torres, Imberti, Davide, Kim, Young Hoon, Guardigli, Gabriele, Ince, H. seyin, Kim, Nam Ho, Guevara, Carolina, Indolfi, Ciro, Kim, Dae Kyeong, Guignier, Alexandre, Inoue, Shujiro, Kim, Jeong Su, Gulizia, Michele, Irles, Didier, Kim, June Soo, Gumbley, Michael, Iseki, Harukazu, Kim, Ki Seok, Günther, Albrecht, Israel, C. Noah, Kim, Jin bae, Ha, Andrew, Iteld, Bruce, Kinova, Elena, Hahalis, Georgios, Iyer, Venkat, Klein, Alexander, Hakas, Joseph, Jackson-Voyzey, Ewart, Kmetzo, James J., Hall, Christian, Jaffrani, Naseem, Kneller, G. Larsen, Han, Bing, Jäger, Frank, Knezevic, Aleksandar, Han, Seongwook, James, Martin, Koh, Su Mei Angela, Hargrove, Joe, Jang, Sung-Won, Koide, Shunichi, Hargroves, David, Jaramillo, Nicolas, Kollias, Anastasios, Kooistra, J. A., Li, Weihua, McClure, John, Koons, Jay, Li, Xiaoming, McCormack, Terry, Koschutnik, Martin, Lichy, Christhoh, McGarity, William, Kostis, William J., Lieber, Ira, McIntyre, Hugh, Kovacic, Dragan, Rodriguez, Ramon Horacio Limon, McLaurin, Brent, Kowalczyk, Jacek, Lin, Hailong, Alvaro, Feliz, Palomino, Medina, Koziolova, Natalya, Melandri, Francesco, Kraft, Peter, Liu, Feng, Meno, Hiroshi, Kragten, Johannes A., Liu, Hengliang, Menzies, Dhananjai, Krantz, Mori, Esperon, Guillermo Llamas, Mercader, Marco, Krause, Lars, Navarro, Nassip Llerena, Meyer, Christian, Krenning, B. J., Lo, Eric, Meyer, Beat J., Krikke, F., Lokshyn, Sergiy, Miarka, Jacek, Kromhout, Z., López, Amador, Mibach, Frank, Krysiak, Waldemar, López-Sendón, José Luís, Michalski, Dominik, Kumar, Priya, Filho, Adalberto Menezes Lorga, Michel, Patrik, Kümler, Thomas, Lorraine, Richard S., Chreih, Rami Mihail, Kuniss, Malte, Luengas, Carlos Alberto, Luengas, Alberto, Mikdadi, Ghiath, Kuo, Jen-Yuan, Luke, Robert, Mikus, Milan, Küppers, Achim, Luo, Ming, Milicic, Davor, Kurrelmeyer, Karla, Lupovitch, Steven, Militaru, Constantin, Kwak, Choong Hwan, Lyrer, Philippe, Minaie, Sedi, Laboulle, B. nédicte, Ma, Changsheng, Minescu, Bogdan, Labovitz, Arthur, Ma, Genshan, Mintale, Iveta, ter Lai, Wen, Madariaga, Irene, Mirault, Tristan, Lam, Andy, Maeno, Koji, Mirro, Michael J., Lam, Yat Yin, Magnin, Dominique, Mistry, Dinesh, Lanas Zanetti, Fernando, Maid, Gustavo, Miu, Nicoleta Violeta, Landau, Charles, Mainigi, Sumeet K., Miyamoto, Naomasa, Landini, Giancarlo, Makaritsis, Konstantinos, Moccetti, Tiziano, Lanna Figueiredo, Estêvão, Malhotra, Rohit, Mohammed, Akber, Larsen, Torben, Manning, Rickey, Nor, Azlisham Mohd, Lavandier, Karine, Manolis, Athanasios, Mollerus, Michael, LeBlanc, Jessica, Hurtado, Helard Andres Manrique, Molon, Giulio, Lee, Moon Hyoung, Mantas, Ioannis, Mondillo, Sergio, Lee, Chang-Hoon, Jattin, Fernando Manzur, Moniz, Patrícia, Lehman, John, Maqueda, Vicky, Mont, Lluis, Leitão, Ana, Marchionni, Niccolo, Montagud, Vicente, Lellouche, Nicolas, Ortuno, Francisco Marin, Montaña, Oscar, Lelonek, Malgorzata, Santana, Antonio Martín, Monti, Cristina, Lenarczyk, Radoslaw, Martinez, Jorge, Moretti, Luciano, Lenderink, T., Maskova, Petra, Mori, Kiyoo, González, Salvador León, Hernandez, Norberto Matadamas, Moriarty, Andrew, Leong-Sit, Peter, Matsuda, Katsuhiro, Morka, Jacek, Leschke, Matthias, Maurer, Tillmann, Moschini, Luigi, Ley, Nicolas, Mauro, Ciro, Moschos, Nikitas, Li, Zhanquan, May, Erik, Mügge, Andreas, Li, Xiaodong, Mayer, Nolan, Mulhearn, Thomas J., Muresan, Carmen, Jose, Eena Padayattil, Précoma, Dalton Bertolim, Muriago, Michela, Padilla, Francisco Gerardo Padilla, Prelle, Alessandro, Musial, Wlodzimierz, Rios, Victoria Padilla, Prodafikas, John, Musser, Carl W., Pajes, Giuseppe, Protasov, Konstantin, Musumeci, Francesco, Pandey, A. Shekhar, Pye, Maurice, Nageh, Thuraia, Paparella, Gaetano, Qiu, Zhaohui, Nakagawa, Hidemitsu, Paris, F., Quedillac, Jean-Michel, Nakamura, Yuichiro, Park, Hyung Wook, Raev, Dimitar, Nakayama, Toru, Park, Jong Sung, Grado, Carlos Antonio Raffo, Nam, Gi-Byoung, Parthenakis, Fragkiskos, Rahimi, Sidiqullah, Nanna, Michele, Passamonti, Enrico, Raisaro, Arturo, Natarajan, Indira, Patel, Rajesh J., Rama, Bhola, Nayak, Hemal M., Patel, Jaydutt, Ramos, Ricardo, Naydenov, Stefan, Patel, Mehool, Ranieri, Maria, Nazlić, Jurica, Patrick, Janice, Raposo, Nuno, Nechita, Alexandru Cristian, Jimenez, Ricardo Pavón, Rashba, Eric, Nechvatal, Libor, Paz, Analía, Rauch-Kroehnert, Ursula, Negron, Sandra Adela, Pengo, Vittorio, Reddy, Ramakota, Neiman, James, Pentz, William, Renda, Giulia, Neuenschwander, Fernando Carvalho, Pérez, Beatriz, Reza, Shabbir, Neves, David, Ríos, Alma Minerva P. rez, Ria, Luigi, Neykova, Anna, Pérez-Cabezas, Alejandro, Richter, Dimitrios, Miguel, Ricardo Nicolás, Perlman, Richard, Rickli, Hans, Nijmeh, George, Persic, Viktor, Rieker, Werner, Nizov, Alexey, Perticone, Francesco, Vera, Tomas Ripolil, Campos, Rodrigo Noronha, Peters, Terri K., Ritt, Luiz Eduardo, Nossan, Janko, Petkar, Sanjiv, Roberts, Douglas, Novikova, Tatiana, Pezo, Luis Felipe, Briones, Ignacio Rodriguez, Nowalany-Kozielska, Ewa, Pflücke, Christian, Escudero, Aldo Edwin Rodriguez, Nsah, Emmanuel, Pham, David N., Pascual, Carlos Rodríguez, Fragoso, Juan Carlos Nunez, Phillips, Roland T., Roman, Mark, Nurgalieva, Svetlana, Phlaum, Stephen, Romeo, Francesco, Nuyens, Dieter, Pieters, Denis, Ronner, E., Nyvad, Ole, Pineau, Julien, Roux, Jean-Francois, de Los Rios Ibarra, Manuel Odin, Pinter, Arnold, Rozkova, Nadezda, O’Donnell, Philip, Pinto, Fausto, Rubacek, Miroslav, O’Donnell, Martin, Pisters, R., Rubalcava, Frank, Oh, Seil, Pivac, Nediljko, Russo, Andrea M., Oh, Yong Seog, Pocanic, Darko, Rutgers, Matthieu Pierre, Oh, Dongjin, Podoleanu, Cristian, Rybak, Karin, O‘Hara, Gilles, Politano, Alessandro, Said, Samir, Oikonomou, Kostas, Poljakovic, Zdravka, Sakamoto, Tamotsu, Olivares, Claudia, Pollock, Stewart, Salacata, Abraham, Oliver, Richard, Garcéa, Jose Polo, Salem, Adrien, Ruiz, Rafael Olvera, Poppert, Holger, Bodes, Rafael Salguero, Olympios, Christoforos, Porcu, Maurizio, Saltzman, Marco A., Omaszuk-Kazberuk, Anna, Reino, Antonio Pose, Salvioni, Alessandro, Asensi, Joaquín Osca, Prasad, Neeraj, Vallejo, Gregorio Sanchez, Fernández, Marcelo Sanmartín, Sokal, Adam, Tu, Tian Ming, Saporito, Wladmir Faustino, Yan, Yannie Soo Oi, Tuininga, Ype, Sarikonda, Kesari, Sotolongo, Rodolfo, Turakhia, Minang, Sasaoka, Taishi, de Souza, Olga Ferreira, Turk, Samir, Sati, Hamdi, Sparby, Jon Arne, Turner, Wayne, Savelieva, Irina, Spinar, Jindrich, Tveit, Arnljot, Scala, Pierre-Jean, Sprigings, David, Tytus, Richard, Schellinger, Peter, Spyropoulos, Alex C., Valadão, C., Scherr, Carlos, Stakos, Dimitrios, van Bergen, P. F. M. M., Schmitz, Lisa, Steinwender, Clemens, van de Borne, Philippe, Schmitz, Karl-Heinz, Stergiou, Georgios, van den Berg, B. J., Schmitz, Bettina, Stiell, Ian, van der Zwaan, C., Schnabel, Teresa, Stoddard, Marcus, van Eck, M., Schnupp, Steffen, Stoikov, Anastas, Vanacker, Peter, Schoeniger, Peter, Streb, Witold, Vasilev, Dimo, Schön, Norbert, Styliadis, Ioannis, Vasilikos, Vasileios, Schwimmbeck, Peter, Su, Guohai, Vasilyev, Maxim, Seamark, Clare, Su, Xi, Veerareddy, Srikar, Searles, Greg, Sudnik, Wanda, Miño, Mario Vega, Seidl, Karl-Heinz, Sukles, Kai, Venkataraman, Asok, Seidman, Barry, Sun, Xiaofei, Verdecchia, Paolo, Sek, Jaroslaw, Swart, H., Versaci, Francesco, Sekaran, Lakshmanan, Szavits-Nossan, Janko, Vester, Ernst G. nter, Serrati, Carlo, Taggeselle, Jens, Vial, Hubert, Shah, Neerav, Takagi, Yuichiro, Victory, Jason, Shah, Vinay, Takhar, Amrit Pal Singh, Villamil, Alejandro, Shah, Anil, Tamm, Angelika, Vincent, Marc, Shah, Shujahat, Tanaka, Katsumi, Vlastaris, Anthony, Sharma, Vijay Kumar, Tanawuttiwat, Tanyanan, Dahl, J. rgen vom, Shaw, Louise, Tang, Sherman, Vora, Kishor, Sheikh, Khalid H., Tang, Aylmer, Vranian, Robert B., Shimizu, Naruhito, Tarsi, Giovanni, Wakefield, Paul, Shimomura, Hideki, Tassinari, Tiziana, Wang, Ningfu, Shin, Dong-Gu, Tayal, Ashis, Wang, Mingsheng, Shin, Eun-Seok, Tayebjee, Muzahir, Wang, Xinhua, Shite, Junya, Berg, J. M. ten, Wang, Feng, Sibilio, Gerolamo, Tesloianu, Dan, Wang, Tian, Silver, Frank, The, Salem H. K., Warner, Alberta L., Sime, Iveta, Thomas, Dierk, Watanabe, Kouki, Simmers, Tim A., Timsit, Serge, Wei, Jeanne, Singh, Narendra, Tobaru, Tetsuya, Weimar, Christian, Siostrzonek, Peter, Tomasik, Andrzej R., Weiner, Stanislav, Smadja, Didier, Torosoff, Mikhail, Weinrich, Renate, Smith, David W., Touze, Emmanuel, Wen, Ming-Shien, Snitman, Marcelo, Trendafilova, Elina, Wiemer, Marcus, Filho, Dario Sobral, Tsai, W. Kevin, Wiggers, Preben, Soda, Hassan, Tse, Hung Fat, Wilke, Andreas, Sofley, Carl, Tsutsui, Hiroshi, Williams, David, Williams, Marcus L., Yan, Ping Yen Bryan, Zhang, Ping, Witzenbichler, Bernhard, Yang, Tianlun, Zhang, Jun, Wong, Brian, Yao, Jing, Zhao, Shui Ping, Wong, Ka Sing Lawrence, Yeh, Kuo-Ho, Zhao, Yujie, Wozakowska-Kaplon, Beata, Yin, Wei Hsian, Zhao, Zhichen, Wu, Shulin, Yotov, Yoto, Zheng, Yang, Wu, Richard C., Zahn, Ralf, Zhou, Jing, Wunderlich, Silke, Zarich, Stuart, Zimmermann, Sergio, Wyatt, Nell, Zenin, Sergei, Zini, Andrea, Wylie, John, Zeuthen, Elisabeth Louise, Zizzo, Steven, Xu, Yong, Zhang, Huanyi, Zong, Wenxia, Xu, Xiangdong, Zhang, Donghui, Zukerman, L. Steven, Yamanoue, Hiroki, Zhang, Xingwei, Yamashita, Takeshi, Cardiology, and ACS - Heart failure & arrhythmias

Abstract

In this article, the name of the GLORIA-AF investigator Anastasios Kollias was given incorrectly as Athanasios Kollias in the Acknowledgements. The original article has been corrected.

Published
2022

30. Phrenic Nerve Injury During Cryoballoon-Based Pulmonary Vein Isolation: Results of the Worldwide YETI Registry

Author

Heeger, Christian-H, Sohns, Christian, Pott, Alexander, Metzner, Andreas, Inaba, Osamu, Straube, Florian, Kuniss, Malte, Aryana, Arash, Miyazaki, Shinsuke, Cay, Serkan, Ehrlich, Joachim R, El-Battrawy, Ibrahim, Martinek, Martin, Saguner, Ardan M, Tscholl, Verena, Yalin, Kivanc, Lyan, Evgeny, Su, Wilber, Papiashvili, Giorgi, Botros, Maichel Sobhy Naguib, Gasperetti, Alessio, Proietti, Riccardo, Wissner, Erik, Scherr, Daniel, Kamioka, Masashi, Makimoto, Hisaki, Urushida, Tsuyoshi, Aksu, Tolga, Chun, Julian K R, Aytemir, Kudret, et al, and University of Zurich

Subjects
2737 Physiology (medical), 10209 Clinic for Cardiology, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine
Published
2022
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33. Impact of cryoballoon application abortion due to phrenic nerve injury on reconnection rates: a YETI subgroup analysis.

Author

Heeger, Christian-H, Popescu, Sorin Ștefan, Sohns, Christian, Pott, Alexander, Metzner, Andreas, Inaba, Osamu, Straube, Florian, Kuniss, Malte, Aryana, Arash, Miyazaki, Shinsuke, Cay, Serkan, Ehrlich, Joachim R, El-Battrawy, Ibrahim, Martinek, Martin, Saguner, Ardan M, Tscholl, Verena, Yalin, Kivanc, Lyan, Evgeny, Su, Wilber, and Papiashvili, Giorgi

Abstract

Aims: Cryoballoon (CB)-based pulmonary vein isolation (PVI) is an effective treatment for atrial fibrillation (AF). The most frequent complication during CB-based PVI is right-sided phrenic nerve injury (PNI) which is leading to premature abortion of the freeze cycle. Here, we analysed reconnection rates after CB-based PVI and PNI in a large-scale population during repeat procedures.Methods and Results: In the YETI registry, a total of 17 356 patients underwent CB-based PVI in 33 centres, and 731 (4.2%) patients experienced PNI. A total of 111/731 (15.2%) patients received a repeat procedure for treatment of recurrent AF. In 94/111 (84.7%) patients data on repeat procedures were available. A total of 89/94 (94.7%) index pulmonary veins (PVs) have been isolated during the initial PVI. During repeat procedures, 22 (24.7%) of initially isolated index PVs showed reconnection. The use of a double stop technique did non influence the PV reconnection rate (P = 0.464). The time to PNI was 140.5 ± 45.1 s in patients with persistent PVI and 133.5 ± 53.8 s in patients with reconnection (P = 0.559). No differences were noted between the two populations in terms of CB temperature at the time of PNI (P = 0.362). The only parameter associated with isolation durability was CB temperature after 30 s of freezing. The PV reconnection did not influence the time to AF recurrence.Conclusion: In patients with cryoballon application abortion due to PNI, a high rate of persistent PVI rate was found at repeat procedures. Our data may help to identify the optimal dosing protocol in CB-based PVI procedures.Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT03645577?term=YETI&cntry=DE&draw=2&rank=1 ClinicalTrials.gov Identifier: NCT03645577. [ABSTRACT FROM AUTHOR]

Published
2023
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34. A rare case of right heart failure with the necessity for veno‐arterial extracorporeal membrane oxygenation following pulmonary vein stenosis after radiofrequency ablation for atrial fibrillation.

Author

Kopp, Sabrina, Tilch, Marie‐Kristin, Sagoschen, Ingo, Kaes, Joachim, Kuniss, Malte, Neumann, Thomas, Yang, Yang, Schnitzler, Katharina, Schmidt, Kai‐Helge, Rostock, Thomas, Münzel, Thomas, Konstantinides, Stavros, Wild, Johannes, and Hobohm, Lukas

Subjects
PULMONARY veins, EXTRACORPOREAL membrane oxygenation, ATRIAL flutter, PULMONARY stenosis, ATRIAL fibrillation, HEART failure
Abstract

Pulmonary vein stenosis (PVS) after radiofrequency energy‐mediated percutaneous pulmonary vein isolation as a treatment option for atrial fibrillation is a serious complication and the prevalence in historical reports varies between 0% and 42%. Symptoms of PVS are nonspecific and can include general symptoms such as dyspnea, cough, recurrent pneumonia, and chest pain. Pathophysiologically it increases the postcapillary pressure in the pulmonary circuit and may result in pulmonary hypertension (PH). Misdiagnosis and delayed treatment are common. We here report a case of a 59‐year‐old female with a history of pulmonary vein ablation followed by progressive dyspnea (New York Heart Association IV), right heart failure, CPR, and the need for extracorporeal membrane oxygenation (ECMO). Further treatment strategy includes pulmonary vein dilatation and stenting of both the left superior pulmonary vein and left inferior pulmonary vein, as well as balloon dilatation of RIPV under temporary ECMO support. Symptomatic, severe PVS is a rare complication after catheter ablation of atrial fibrillation. PVS can result in life‐ threatening complications such as PH with acute right heart failure. Early diagnosis is crucial but challenging. Mechanical cardiopulmonary support by veno‐arterial ECMO for bridging to angioplasty could be a lifesaving option. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Cryoballoon ablation vs. antiarrhythmic drugs

Author

Cryo-FIRST Investigators, Kuniss, Malte, Pavlovic, Nikola, Velagic, Vedran, Hermida, Jean Sylvain, Healey, Stewart, Arena, Giuseppe, Badenco, Nicolas, Meyer, Christian, Chen, Jian, Iacopino, Saverio, Anselme, Frédéric, Packer, Douglas L, Pitschner, Heinz-Friedrich, de Asmundis, Carlo, Willems, Stephan, Di Piazza, Fabio, Becker, Daniel, Chierchia, Gian-Battista, Clinical sciences, Heartrhythmmanagement, HAL-SU, Gestionnaire, Kerckhoff-Klinik, University Hospital Sestre Milosrdnice, University Hospital Centre Zagreb, Partenaires INRAE, CHU Amiens-Picardie, Monash Health and Hudson Institute, Institut de cardiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University Heart Center [Hamburg], Haukeland University Hospital, University of Bergen (UiB), Maria Cecilia Hospital [Cotignola], CHU Rouen, Normandie Université (NU), Mayo Clinic, Vrije Universiteit Brussel (VUB), Medtronic SNT, Medtronic, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP]

Subjects
[SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery, medicine.medical_treatment, cryoballoon, 030204 cardiovascular system & hematology, Rate ratio, Cryosurgery, 0302 clinical medicine, Recurrence, Atrial Fibrillation, Clinical endpoint, Palpitations, AcademicSubjects/MED00200, 030212 general & internal medicine, Cryosurgery* / adverse effects, Atrial Fibrillation* / surgery, Atrial fibrillation, Ablation for Atrial Fibrillation, 3. Good health, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Treatment Outcome, Antiarrhythmic drug, Pulmonary Veins, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Cardiology, Catheter Ablation, Atrial Fibrillation* / drug therapy, medicine.symptom, Cardiology and Cardiovascular Medicine, Anti-Arrhythmia Agents, medicine.medical_specialty, Pulmonary Veins* / surgery, First-line treatment, Catheter ablation, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Clinical Research, Catheter Ablation* / adverse effects, Physiology (medical), Internal medicine, medicine, Atrial Fibrillation* / diagnosis, Humans, Atrial tachycardia, Surrogate endpoint, business.industry, medicine.disease, Anti-Arrhythmia Agents / adverse effects, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, business, randomized study, Atrial flutter
Abstract

Aims Treatment guidelines for patients with atrial fibrillation (AF) suggest that patients should be managed with an antiarrhythmic drug (AAD) before undergoing catheter ablation (CA). This study evaluated whether pulmonary vein isolation employing cryoballoon CA is superior to AAD therapy for the prevention of atrial arrhythmia (AA) recurrence in rhythm control naive patients with paroxysmal AF (PAF). Methods and results A total of 218 treatment naive patients with symptomatic PAF were randomized (1 : 1) to cryoballoon CA (Arctic Front Advance, Medtronic) or AAD (Class I or III) and followed for 12 months. The primary endpoint was ≥1 episode of recurrent AA (AF, atrial flutter, or atrial tachycardia) >30 s after a prespecified 90-day blanking period. Secondary endpoints included the rate of serious adverse events (SAEs) and recurrence of symptomatic palpitations (evaluated via patient diaries). Freedom from AA was achieved in 82.2% of subjects in the cryoballoon arm and 67.6% of subjects in the AAD arm (HR = 0.48, P = 0.01). There were no group differences in the time-to-first (HR = 0.76, P = 0.28) or overall incidence [incidence rate ratio (IRR)=0.79, P = 0.28] of SAEs. The incidence rate of symptomatic palpitations was lower in the cryoballoon (7.61 days/year) compared with the AAD arm (18.96 days/year; IRR = 0.40, P, Graphical Abstract

Published
2021
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39. Prospective randomized comparison of durability of bidirectional conduction block in the cavotricuspid isthmus in patients after ablation of common atrial flutter using cryothermy and radiofrequency energy: The CRYOTIP study

Author

Kuniss, Malte, Vogtmann, Thomas, Ventura, Rodolfo, Willems, Stephan, Vogt, Jürgen, Grönefeld, Gerian, Hohnloser, Stefan, Zrenner, Bernhard, Erdogan, Ali, Klein, Gunnar, Lemke, Bernd, Neuzner, Jörg, Neumann, Thomas, Hamm, Christian W., and Pitschner, Heinz-Friedrich

Published
2009
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40. Guideline Directed Medical Therapy at Discharge and Further Uptitration Leading to Reduction in Indication for Prophylactic ICD Implantation during Protected Waiting Period.

Author

Waezsada, Elias, Hutter, Julie, Kahle, Patrick, Yogarajah, Joerg, Sperzel, Johannes, Kuniss, Malte, Neumann, Thomas, Esser, Horst, Hamm, Christian, and Hain, Andreas

Subjects
HEART failure, TOOTH abrasion, CARDIAC arrest, HOSPITAL admission & discharge, VENTRICULAR arrhythmia, VENTRICULAR tachycardia, IMPLANTABLE cardioverter-defibrillators
Abstract

Heart failure with reduced ejection fraction (LV-EF < 35%) is diagnosed in app. 11,000,000 patients worldwide. For the treatment of these patients, guideline directed medical therapy has proven to reduce mortality and rehospitalization regardless of the disease's etiology. It is implemented to treat clinical symptoms by improving the left ventricular ejection fraction. Patients with a transient risk of ventricular tachycardia and sudden cardiac death can be protected by a defibrillator vest. The defibrillator vest is capable to detect and terminate ventricular arrhythmias during Guideline Directed Medical Therapy (GDMT). It is based on the recommendations of the European society of cardiology for 3 months. Afterwards, the WCD wear time could be prolonged, or, in case of persistent low ejection fraction (LV-EF ≤ 35%), an implantable cardioverter defibrillator (ICD) should be implanted, as shown in the WEARIT-II-registry. Our goal was to evaluate the effects of GDMT on LV-recovery and reduction of ICD implantations under protection with a defibrillator vest—depending on the uptitration of GDMT. Methods: 339 consecutive patients between August 2017 and September 2020 with newly diagnosed cardiomyopathy and an EF ≤ 35% were analyzed retrospectively by chart review. All patients were protected by a wearable cardioverter defibrillator (WCD). GDMT as recommended by the ESC started at discharge from hospital. The left ventricular ejection fraction (LV-EF) was determined by transthoracic echocardiography at week 4, 8 and at week 12 (in case of prolonged WCD wear time). Uptitration was performed after 4 and 8 weeks during patient visits. We focused on baseline medication as per GDMT and the dosage increase at week 4, 8 and 12. The aim was the uptitration to the maximum dosage tolerated by the patient. We also compared the LV-EF improvement in the group with and without uptitration of medication dosage. Results: The patient age was, on average, 63.2 years (SD ± 11.9 years). A total of 129 pts (38%) had ICM, 196 (58%) had NICM (incl 66 pts (19%) with DCM and 51 pts (15%) with Myocarditis, 79 pts (24%) with unknown origin) and 14 pts (4%) had other entities (e.g., Tachycardiomyopathy). In total, 21 pts (6%) had an LV-EF of less than 16%, 130 pts (38%) between 16–25% and 183 pts (54%) between 26–35%. GDMT started at discharge from the hospital included treatment with beta blocker for 327 pts (96.5%), ACE-inhibitors/Angiotensin/ARNI for 283 pts (83.5%) and Mineralcorticoid receptor antagonists (MRA) for 334 pts (88.4%). Uptitration was performed in all groups at a rate of 82.3%, 91.1% and 81.0% after 4 weeks and 64.7%, 50.3% and 66.3% after 8 weeks, respectively. After 4 weeks, 25 pts (7.4%) and, after 8 weeks, 171 pts (50.4%) had an EF increase of 5% or more (mean 14.2%). After 4 weeks, 81 patients had an LV-EF more than 35%. A total of 169 pts had a wear time of 12 weeks and an improvement of LVEF of more than 35%. Interestingly, in our study we did not find a significant difference in LV-EF improvement between the group with no uptitration and the group with uptitration. Conclusions: Guideline-directed medical therapy under protection with a WCD from ventricular arrhythmia can reduce the need for implantation of an ICD and can lead to an improvement of ejection fraction. Interestingly, the LV-EF improvement depends on the GDMT at discharge. Current guidelines recommend an initiation of all therapy columns of GDMT (sacubitril/valsartan, ACE-inhibitor/AT1-blocker, mineralcorticoidreceptorblocker, beta blocker) at once and further uptitration to the maximal dosage (ESC Guidelines 2021). A further uptitration of all drugs of GDMT should lead to improvement of LV-EF and consequently to a reduction in ICD implantations. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Survival with Cardiac-Resynchronization Therapy in Mild Heart Failure

Author

Goldenberg, Ilan, Kutyifa, Valentina, Klein, Helmut U., Cannom, David S., Brown, Mary W., Dan, Ariela, Daubert, James P., Estes, Mark N.A., III, Foster, Elyse, Greenberg, Henry, Kautzner, Josef, Klempfner, Robert, Kuniss, Malte, Merkely, Bela, Pfeffer, Marc A., Quesada, Aurelio, Viskin, Sami, McNitt, Scott, Polonsky, Bronislava, Ghanem, Ali, Solomon, Scott D., Wilber, David, Zareba, Wojciech, and Moss, Arthur J.

Published
2014
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48. New evidence: Cryoballoon ablation vs. antiarrhythmic drugs for first-line therapy of atrial fibrillation.

Author

Andrade, Jason G, Chierchia, Gian-Battista, Kuniss, Malte, and Wazni, Oussama M

Subjects
ATRIAL fibrillation diagnosis, MYOCARDIAL depressants, FERRANS & Powers Quality of Life Index, ATRIAL fibrillation, CATHETER ablation, CRYOSURGERY, TREATMENT effectiveness, QUALITY of life, RESEARCH funding
Abstract

Atrial fibrillation (AF) is a commonly encountered chronic and progressive heart rhythm disorder, characterized by exacerbations and remissions. Contemporary clinical practice guidelines recommend a trial of antiarrhythmic drugs (AADs) as the initial therapy for sinus rhythm maintenance; however, these medications have modest efficacy and are associated with significant adverse effects. Recently, several trials have demonstrated that an initial treatment strategy of cryoballoon catheter ablation significantly improves arrhythmia outcomes (e.g. freedom atrial tachyarrhythmia and reduction in arrhythmia burden), produces clinically meaningful improvements in patient-reported outcomes (e.g. symptoms and quality of life), and significantly reduces subsequent healthcare resource utilization (e.g. hospitalization), without increasing the risk of serious or any adverse events. These findings are relevant to patients, providers, and healthcare systems, helping inform the decision regarding the initial choice of rhythm-control therapy in patients with treatment-naïve AF. [ABSTRACT FROM AUTHOR]

Published
2022
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